Unconventional myosin-VI
UniProt Q9UM54 · gene MYO6 · Homo sapiens · 1294 residues
27evidence items
0mapped to a state
0states
6techniques
4sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 27 of 27 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 6 | 0 |
| RCSB PDB | 8 | 0 |
| SMASH-BIO | 12 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-8W41-2 RCSB PDB | cryoem | resolution: 3.54 Å | in vitro · ligands ADP, CA, MG, PO4 Cryo-EM structure of Myosin VI in the autoinhibited state · Unconventional myosin-VI (chains A) | unmapped |
| EV-PDB-6J56-1 RCSB PDB | xray | resolution: 1.798 Å | in vitro · -173.15 °C Crystal structure of Myosin VI CBD in complex with Tom1 MBM · Unconventional myosin-VI (chains A,B) | unmapped |
| EV-PDB-6E5N-1 RCSB PDB | nmr_structure | structure | in vitro · 10.05 °C · pH 6.5 Solution structure of human Myosin VI isoform 3 (1050-1131) in complex with Clathrin light chain a (46-61) · Unconventional myosin-VI (chains B) | unmapped |
| EV-PDB-2N13-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 6.5 Complex structure of MyUb (1080-1122) of human Myosin VI with K63-diUb · Unconventional myosin-VI (chains A,D) | unmapped |
| EV-PDB-2N12-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 6.5 Solution structure of human Myosin VI isoform3 (1050-1131) · Unconventional myosin-VI (chains A) | unmapped |
| EV-PDB-2N11-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 6.5 Solution structure of human Myosin VI isoform3 (998-1071) · Unconventional myosin-VI (chains A) | unmapped |
| EV-PDB-2N10-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 6.5 Solution structure of MyUb (1080-1131) of human Myosin VI · Unconventional myosin-VI (chains A) | unmapped |
| EV-PDB-2N0Z-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 6.5 Solution structure of MyUb (1080-1122) of human Myosin VI · Unconventional myosin-VI (chains A) | unmapped |
| EV-BMRB-25541 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 6.5 Solution structure of MyUb (1080-1122) of human Myosin VI · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25542 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 6.5 Solution structure of MyUb (1080-1131) of human Myosin VI · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25543 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 6.5 Solution structure of human Myosin VI isoform3 (998-1071) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25544 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 6.5 Solution structure of human Myosin VI isoform3 (1050-1131) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25545 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 6.5 Complex structure of MyUb (1080-1122) of human Myosin VI with K63-diUb · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30500 BMRB | nmr_shifts | chemical_shift | in vitro · 10.05 °C · pH 6.5 Structure of a protein complex · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-Q9UM54-F1 AlphaFold DB | af_prediction | plddt: 78.88 pLDDT | in silico AlphaFold DB prediction AF-Q9UM54-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-1294 | unmapped |
| EV-SMASH-SMFS-002908 SMASH-BIO | force_spectroscopy | study_record | in vitro Stiffness of Cargo-Motor Linkage Tunes Myosin VI Motility and Response to Load. · Myosin VI; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-003805 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 A programmable DNA origami nanospring that reveals force-induced adjacent binding of myosin VI heads. · Myosin VI; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-005632 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Robust mechanosensing and tension generation by myosin VI. · Myosin VI; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-005751 SMASH-BIO | force_spectroscopy | study_record | in vitro Contribution of the myosin VI tail domain to processive stepping and intramolecular tension sensing. · Myosin VI; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006008-r0 SMASH-BIO | force_spectroscopy | persistence_length: 15 nm | in vitro Combining single-molecule optical trapping and small-angle x-ray scattering measurements to compute the persistence length of a protein ER/K alpha-helix. · Myosin VI; optical tweezers; experiment class: force_generation_motor, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-006514 SMASH-BIO | force_spectroscopy | study_record | in vitro A survey of single-molecule techniques in chemical biology. · Myosin VI; optical tweezers; experiment class: force_generation_motor, translation_transcription_replication, unfolding_protein | unmapped |
| EV-SMASH-SMFS-006721 SMASH-BIO | force_spectroscopy | study_record | in vitro The power stroke of myosin VI and the basis of reverse directionality. · Myosin VI; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007100 SMASH-BIO | force_spectroscopy | study_record | in vitro A monomeric myosin VI with a large working stroke. · Myosin VI; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007165 SMASH-BIO | force_spectroscopy | study_record | in vitro Myosin VI: a multifunctional motor. · Myosin VI; optical tweezers; experiment class: force_generation_motor, membrane_mechanics | unmapped |
| EV-SMASH-SMFS-007166 SMASH-BIO | force_spectroscopy | study_record | in vitro Myosin VI: cellular functions and motor properties. · Myosin VI; optical tweezers; experiment class: force_generation_motor, membrane_mechanics | unmapped |
| EV-SMASH-SMFS-007213 SMASH-BIO | force_spectroscopy | study_record | in vitro The mechanism of myosin VI translocation and its load-induced anchoring. · Myosin VI; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007442 SMASH-BIO | force_spectroscopy | study_record | in vitro Myosin VI is a processive motor with a large step size. · Myosin VI; optical tweezers; experiment class: force_generation_motor, membrane_mechanics, rheology_cell | unmapped |
Conflicts
No conflicts found among comparable evidence.
27 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.