Cytoplasmic dynein 1 heavy chain 1
UniProt Q14204 · gene DYNC1H1 · Homo sapiens · 4646 residues
210evidence items
0mapped to a state
0states
4techniques
3sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_shifts | force_spectroscopy | Total |
|---|---|---|---|---|---|---|
| No states defined yet. | ||||||
Unmapped evidence: 210 of 210 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| BMRB | 1 | 0 |
| RCSB PDB | 98 | 0 |
| SMASH-BIO | 111 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-30DR-13 RCSB PDB | cryoem | resolution: 10 Å | in vitro Dynein-Dynactin-RAB11FIP3 complex - composite · Cytoplasmic dynein 1 heavy chain 1 (chains e,f,m,n) | unmapped |
| EV-PDB-5NUG-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands ADP, ATP, MG Motor domains from human cytoplasmic dynein-1 in the phi-particle conformation · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-5OWO-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 5.5 · ligands CA, GOL, K, MG, NA Human cytoplasmic Dynein N-Terminus dimerization domain at 1.8 Angstrom resolution · Cytoplasmic dynein 1 heavy chain 1 (chains A,B,C,D) | unmapped |
| EV-PDB-6F1T-19 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ADP, ATP Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1 · Cytoplasmic dynein 1 heavy chain 1,Cytoplasmic dynein 1 heavy chain 1,Cytoplasmic dynein 1 heavy chain 1,Dynein Heavy Chain,Cytoplasmic dynein 1 heavy chain 1,Cytoplasmic dynein 1 heavy chain 1,Cytoplasmic dynein 1 heavy chain 1,Cytoplasmic dynein 1 heavy chain 1,Dynein Heavy Chain,Cytoplasmic dynein 1 heavy chain 1,Cytoplasmic dynein 1 heavy chain 1 (chains e,f,m,n) | unmapped |
| EV-PDB-6F1U-6 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP N terminal region of dynein tail domains in complex with dynactin filament and BICDR-1 · Cytoplasmic dynein 1 heavy chain 1 (chains f,m,n) | unmapped |
| EV-PDB-6F1V-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro C terminal region of the dynein heavy chains in the dynein tail/dynactin/BICDR1 complex · Cytoplasmic dynein 1 heavy chain 1 (chains f,m) | unmapped |
| EV-PDB-6F1Y-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro Dynein light intermediate chain region of the dynein tail/dynactin/BICDR1 complex · Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain (chains f) | unmapped |
| EV-PDB-6F38-19 RCSB PDB | cryoem | resolution: 6.7 Å | in vitro · ligands ADP, ATP Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 · Cytoplasmic dynein 1 heavy chain 1 (chains e,f,m,n) | unmapped |
| EV-PDB-6F3A-16 RCSB PDB | cryoem | resolution: 8.2 Å | in vitro · ligands ADP, ATP Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N · Cytoplasmic dynein 1 heavy chain 1 (chains e,f) | unmapped |
| EV-PDB-7Z8F-13 RCSB PDB | cryoem | resolution: 20 Å | in vitro · ligands ADP, ANP, ATP, MG, ZN Composite structure of dynein-dynactin-BICDR on microtubules · Cytoplasmic dynein 1 heavy chain 1 (chains e,f,m,n) | unmapped |
| EV-PDB-7Z8G-1 RCSB PDB | cryoem | resolution: 3.52 Å | in vitro · ligands ADP, ANP, ATP, MG Cytoplasmic dynein-1 motor domain · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-7Z8H-1 RCSB PDB | cryoem | resolution: 3.41 Å | in vitro · ligands ADP, ANP, ATP, MG Cytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunits · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-7Z8I-5 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ADP, MG The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2) · Cytoplasmic dynein 1 heavy chain 1 (chains f,m,n) | unmapped |
| EV-PDB-7Z8J-2 RCSB PDB | cryoem | resolution: 3.93 Å | in vitro Cytoplasmic dynein (A2) bound to BICDR1 · Cytoplasmic dynein 1 heavy chain 1 (chains f,m,n) | unmapped |
| EV-PDB-7Z8K-1 RCSB PDB | cryoem | resolution: 4.37 Å | in vitro Cytoplasmic dynein (A1) bound to BICDR1 · Cytoplasmic dynein 1 heavy chain 1 (chains e,f) | unmapped |
| EV-PDB-7Z8L-1 RCSB PDB | cryoem | resolution: 4.9 Å | in vitro · ligands ADP, ANP, ATP, MG Cytoplasmic dynein light intermediate chain (B1) bound to the motor domain (A2). · Cytoplasmic dynein 1 heavy chain 1 (chains f) | unmapped |
| EV-PDB-8DYU-1 RCSB PDB | cryoem | resolution: 4 Å | in vitro · ligands ADP, ATP Structure of human cytoplasmic dynein-1 bound to two Lis1 proteins · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-8DYV-1 RCSB PDB | cryoem | resolution: 3.97 Å | in vitro · ligands ADP, ATP Structure of human cytoplasmic dynein-1 bound to one Lis1 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-8FCY-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, ATP Engineered human dynein motor domain in microtubule-bound state · Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase (chains A) | unmapped |
| EV-PDB-8FD6-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands ADP, ATP, MG, VO4 Engineered human dynein motor domain in the microtubule-unbound state in the buffer containing ATP-Vi · Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase (chains A) | unmapped |
| EV-PDB-8FDT-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands ADP, ATP, VO4 Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi · Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase (chains A) | unmapped |
| EV-PDB-8FDU-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ADP Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1) · Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase (chains A) | unmapped |
| EV-PDB-8PQV-1 RCSB PDB | cryoem | resolution: 4 Å | in vitro · ligands ADP, ANP, ATP Cytoplasmic dynein-1 motor domain in post-powerstroke state · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-8PQW-1 RCSB PDB | cryoem | resolution: 4.2 Å | in vitro · ligands ADP, ATP, MG Cytoplasmic dynein-1 motor domain bound to dynactin-p150glued and LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-8PQY-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands ADP, ATP, MG Cytoplasmic dynein-1 motor domain bound to LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-8PQZ-1 RCSB PDB | cryoem | resolution: 5.5 Å | in vitro · ligands ADP, ATP, MG Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains A,J) | unmapped |
| EV-PDB-8PR0-5 RCSB PDB | cryoem | resolution: 9.4 Å | in vitro Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-8PR1-4 RCSB PDB | cryoem | resolution: 8.2 Å | in vitro Cytoplasmic dynein-B heavy chain bound to IC-LC tower · Cytoplasmic dynein 1 heavy chain 1 (chains A,G) | unmapped |
| EV-PDB-8PR2-2 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI · Cytoplasmic dynein 1 heavy chain 1 (chains f,m) | unmapped |
| EV-PDB-8PR3-2 RCSB PDB | cryoem | resolution: 3.9 Å | in vitro Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1 · Cytoplasmic dynein 1 heavy chain 1 (chains f,m) | unmapped |
| EV-PDB-8PTK-15 RCSB PDB | cryoem | resolution: 10 Å | in vitro · ligands ADP, ANP, ATP, MG, ZN Composite structure of Dynein-Dynactin-JIP3-LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains e,f,m,n) | unmapped |
| EV-PDB-9BLY-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ADP, ATP, MG Composite structure of full-length human dynein-1 in phi-particle conformation · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9BLZ-1 RCSB PDB | cryoem | resolution: 2.2 Å | in vitro · ligands ADP, ATP, MG State-1(phi motor) of full-length human dynein-1 in 5mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM0-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro · ligands ADP, ATP, MG State-2 of motor domain from full-length human dynein-1 in 5mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM1-1 RCSB PDB | cryoem | resolution: 3.02 Å | in vitro · ligands ADP, ATP, MG State-3 of motor domain from full-length human dynein-1 in 5mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM2-1 RCSB PDB | cryoem | resolution: 2.82 Å | in vitro · ligands ADP, ATP, MG State-4 of motor domain from full-length human dynein-1 in 5 mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM3-1 RCSB PDB | cryoem | resolution: 3.49 Å | in vitro · ligands ADP, ATP State-5a of motor domain from full-length human dynein-1 in 5 mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM4-1 RCSB PDB | cryoem | resolution: 3.48 Å | in vitro · ligands ADP, ATP, MG State-5b of motor domain from full-length human dynein-1 in 5 mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM5-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ADP, ATP State-6 of motor domain from full-length human dynein-1 in 5 mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM6-1 RCSB PDB | cryoem | resolution: 3.22 Å | in vitro · ligands ADP, ATP, MG State-7a of motor domain from full-length human dynein-1 in 5 mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM7-1 RCSB PDB | cryoem | resolution: 3.58 Å | in vitro · ligands ADP, ATP State-7b of motor domain from full-length human dynein-1 in 5 mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BM8-1 RCSB PDB | cryoem | resolution: 3.22 Å | in vitro · ligands ADP, ATP State-7c of motor domain from full-length human dynein-1 in 5 mM ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMA-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands ADP, ATP, MG Motor domain from full-length human dynein-1 bound to microtubules in apo condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMB-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands ADP, ATP, MG Post-1 motor domain from full-length human dynein-1 bound to microtubules in 5mM ADP condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMC-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ADP, ATP, MG Post-2 motor domain from full-length human dynein-1 bound to microtubules in 5mM ADP condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMD-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands ADP, ANP, ATP, MG Motor domain from full-length human dynein-1 bound to microtubules in 5mM AMPPNP condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMF-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro · ligands ADP, AOV, ATP, MG State-1(phi motor) of full-length human dynein-1 in 5mM ATPVi · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMG-1 RCSB PDB | cryoem | resolution: 2.86 Å | in vitro · ligands ADP, AOV, ATP, MG State-2 of full-length human dynein-1 in 5mM ATPVi · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMH-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro · ligands ADP, AOV, ATP, MG State-4 of motor domain from full-length human dynein-1 in 5mM ATPVi · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMJ-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands ADP, ATP, MG State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BML-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ADP, ATP, MG State-2 of the motor domain from full-length human dynein-1 in 5mM AMPPNP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMM-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands ADP, ATP, MG State-4 of the motor domain from full-length human dynein-1 in 5mM AMPPNP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMO-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands ADP, ATP State-6 of motor domain from full-length human dynein-1 in 5mM AMPPNP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMT-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro · ligands ADP, ATP State-5 of motor domain from full-length human dynein-1 in 5 mM ADP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9DH8-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ADP, ATP State-5 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+ · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9E0U-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, ATP, MG Cryo-EM structure of human cytoplasmic dynein-1 in the presence of ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9E10-1 RCSB PDB | cryoem | resolution: 2.71 Å | in vitro · ligands ADP, ATP, MG Dimeric motor domains from phi dynein-1 under Lis1 condition · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9YNH-1 RCSB PDB | cryoem | resolution: 5.5 Å | in vitro · ligands ADP, ATP, MG Full-length human cytoplasmic dynein-1 in phi-like state bound to dynactin-p150glued and LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9YNG-12 RCSB PDB | cryoem | resolution: 4.07 Å | in vitro · ligands ADP, ATP, ZN Dynactin and dynein-1 tail region of dynein-dynactin complex on microtubule in the presence of LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains e,f,m,n) | unmapped |
| EV-PDB-9YNF-1 RCSB PDB | cryoem | resolution: 3.92 Å | in vitro · ligands ADP, ANP, ATP, MG Motor domain of human dynein-1 in post1 state · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9YNE-1 RCSB PDB | cryoem | resolution: 8.46 Å | in vitro · ligands ADP, ATP, MG Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B-ICD and LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9YND-1 RCSB PDB | cryoem | resolution: 4.26 Å | in vitro · ligands ADP, ATP, MG Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B and LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9YNC-1 RCSB PDB | cryoem | resolution: 3.93 Å | in vitro · ligands ADP, ATP, MG Motor domains of phi-like human dynein-1 bound to dynactin-p150glued and LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9HHL-13 RCSB PDB | cryoem | resolution: 6.53 Å | in vitro · ligands ADP, ATP, ZN Structure of Dynein-Dynactin-NuMA-LIS1 · Cytoplasmic dynein 1 heavy chain 1 (chains e,f,m,n) | unmapped |
| EV-PDB-9E28-1 RCSB PDB | cryoem | resolution: 4.4 Å | in vitro Cryo-EM structure of Phi dynein tail · Cytoplasmic dynein 1 heavy chain 1 (chains A,G,e,f) | unmapped |
| EV-PDB-9E23-6 RCSB PDB | cryoem | resolution: 6.2 Å | in vitro Cryo-EM structure of Pre-Chi dynein tail · Cytoplasmic dynein 1 heavy chain 1 (chains A,G,e,f) | unmapped |
| EV-PDB-9E22-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ADP, ATP, MG Cryo-EM structure of human cytoplasmic dynein-1 bound to LIS1 in the presence of ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9E14-1 RCSB PDB | cryoem | resolution: 5 Å | in vitro · ligands ADP, ATP, MG Full-length human dynein-1 in phi-like comformation bound to a Lis1 dimer under Nde1-Lis1 condition · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9E13-1 RCSB PDB | cryoem | resolution: 4.5 Å | in vitro · ligands ADP, ATP, MG Full-length human dynein-1 in phi-like comformation bound to a Lis1 dimer under Lis1 condition · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9E12-1 RCSB PDB | cryoem | resolution: 4.5 Å | in vitro · ligands ADP, ATP, MG Full-length human dynein-1 in phi comformation under Lis1 condition · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9E11-1 RCSB PDB | cryoem | resolution: 2.86 Å | in vitro · ligands ADP, ATP, MG Dimeric motor domains from phi-like dynein-1 bound to a Lis1 dimer under Lis1 condition · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9E0Z-1 RCSB PDB | cryoem | resolution: 2.86 Å | in vitro · ligands ADP, ATP, MG Dimeric motor domains from phi-like dynein-1 bound to a Lis1 dimer under Nde1-Lis1 condition · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9E0Y-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, ATP Cryo-EM structure of human cytoplasmic dynein-1 in the presence of ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9E0X-1 RCSB PDB | cryoem | resolution: 2.7 Å | in vitro · ligands ADP, ATP, MG Cryo-EM structure of Phi dynein · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9E0W-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands ADP, ATP, MG Cryo-EM structure of human cytoplasmic dynein-1 bound to LIS1 in the presence of ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9E0T-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands ADP, ATP, MG Cryo-EM structure of human cytoplasmic dynein-1 bound to LIS1 in the presence of ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9E0K-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands ADP, ATP, MG Cryo-EM structure of human cytoplasmic dynein-1 in the presence of ATP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9DZY-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands ADP, ATP, MG Cryo-EM structure of Pre-Chi dynein bound to Lis1 · Cytoplasmic dynein 1 heavy chain 1 (chains A,B) | unmapped |
| EV-PDB-9DHA-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands ADP, ANP, ATP, MG State-7-Post-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+ · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9DH9-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, ANP, ATP, MG State-7-Post-2 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+ · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9DH7-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, ATP, MG State-4 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+ · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9DH6-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, ATP, MG State-2 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+ · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9DH5-1 RCSB PDB | cryoem | resolution: 2.6 Å | in vitro · ligands ADP, ATP, MG State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+ · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BN6-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, ATP The alpha registry-locked dynein motor domain mutant in 5mM ATPVi condition, class2 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BN5-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ADP, ATP The alpha registry-locked dynein motor domain mutant in 5mM ATPVi condition, class1 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BN4-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands ADP, ATP The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class2 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BN3-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro · ligands ADP, ATP The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class1 · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BN1-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands ADP, ATP, MG State-8 of motor domain from full-length human dynein-1 in apo condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BN0-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands ADP, ATP, MG State-7 of motor domain from full-length human dynein-1 in apo condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMZ-1 RCSB PDB | cryoem | resolution: 2.97 Å | in vitro · ligands ADP, ATP, MG State-2 of motor domain from full-length human dynein-1 in apo condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMY-1 RCSB PDB | cryoem | resolution: 2.86 Å | in vitro · ligands ADP, ATP, MG State-1 of motor domain from full-length human dynein-1 in apo condition · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMW-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ADP, ATP, MG State-7b-post2 of motor domain from full-length human dynein-1 in 5 mM ADP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMV-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro · ligands ADP, ATP, MG State-7a-post1 of motor domain from full-length human dynein-1 in 5 mM ADP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMU-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro · ligands ADP, ATP State-6 of motor domain from full-length human dynein-1 in 5 mM ADP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMS-1 RCSB PDB | cryoem | resolution: 3.04 Å | in vitro · ligands ADP, ATP, MG State-2 of motor domain from full-length human dynein-1 in 5 mM ADP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMR-1 RCSB PDB | cryoem | resolution: 2.6 Å | in vitro · ligands ADP, ATP, MG State-1 of motor domain from full-length human phi dynein-1 in 5 mM ADP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMP-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ADP, ANP, ATP State-7 of the motor domain from full-length human dynein-1 in 5mM AMPPNP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-PDB-9BMN-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands ADP, ATP State-5 of motor domain from full-length human dynein-1 in 5mM AMPPNP · Cytoplasmic dynein 1 heavy chain 1 (chains A) | unmapped |
| EV-BMRB-11013 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 6.7 The dynein stalk head, the microtubule binding domain of dynein, derived from mouse · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-SMASH-SMFS-000111-r0 SMASH-BIO | force_spectroscopy | stall_force: 6.3 pN | in vitro Force-Regulated Multimotor Coordination Drives Bidirectional Lipid Droplets Transport in Tunneling Nanotubes. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-000202 SMASH-BIO | force_spectroscopy | study_record | in vitro Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000666 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.3 A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-000723 SMASH-BIO | force_spectroscopy | study_record | in vitro DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3 · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000801 SMASH-BIO | force_spectroscopy | study_record | in vitro Insect Cell-Based Expression of Cytoskeletal Motor Proteins for Single-Molecule Studies. · Cytoplasmic dynein-1; optical tweezers; experiment class: chromatin_mechanics, force_generation_motor, membrane_mechanics | unmapped |
| EV-SMASH-SMFS-000818 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Lis1 slows force-induced detachment of cytoplasmic dynein from microtubules. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-000838 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanics of spindle orientation in human mitotic cells is determined by pulling forces on astral microtubules and clustering of cortical dynein. · Cytoplasmic dynein-1; magnetic tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-000992 SMASH-BIO | force_spectroscopy | study_record | in vitro Theoretical analysis of cargo transport by catch bonded motors in optical trapping assays. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001032 SMASH-BIO | force_spectroscopy | study_record | in vitro A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-001046 SMASH-BIO | force_spectroscopy | study_record | in vitro Acidification of the phagosome orchestrates the motor forces directing its transport. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-001083 SMASH-BIO | force_spectroscopy | study_record | in vitro Clustering of cortical dynein regulates the mechanics of spindle orientation in human mitotic cells · Cytoplasmic dynein-1; magnetic tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-001184 SMASH-BIO | force_spectroscopy | study_record | in vitro Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001193 SMASH-BIO | force_spectroscopy | study_record | in vitro In Vivo Trapping of Latex Bead Phagosomes for Quantitative Force Measurements. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001221 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.8 Measurements of the Force-Dependent Detachment Rates of Cytoplasmic Dynein from Microtubules. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, rheology_cell | unmapped |
| EV-SMASH-SMFS-001294 SMASH-BIO | force_spectroscopy | study_record | in vitro Reconstitution of Organelle Transport Along Microtubules In Vitro. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001338 SMASH-BIO | force_spectroscopy | study_record | in vitro Studying Dynein Mechanochemistry with an Optical Trap. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-001373 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Versatile properties of dynein molecules underlying regulation in flagellar oscillation. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001437 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.8 Catching the Conformational Wave: Measuring the Working Strokes of Protofilaments as They Curl Outward from Disassembling Microtubule Tips. · Cytoplasmic dynein-1; optical tweezers; experiment class: chromatin_mechanics, force_generation_motor | unmapped |
| EV-SMASH-SMFS-001484 SMASH-BIO | force_spectroscopy | study_record | in vitro Directly Measuring Forces within Reconstituted Active Microtubule Bundles. · Cytoplasmic dynein-1; optical tweezers; experiment class: chromatin_mechanics, force_generation_motor, membrane_mechanics, rheology_cell | unmapped |
| EV-SMASH-SMFS-001550 SMASH-BIO | force_spectroscopy | study_record | in vitro Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001567 SMASH-BIO | force_spectroscopy | study_record | in vitro Lis1 binding regulates force-induced detachment of cytoplasmic dynein from microtubules · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-001569 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Long-range electrostatic interactions significantly modulate the affinity of dynein for microtubules. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001607 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Microtubule Dumbbells to Assess the Effect of Force Geometry on Single Kinesin Motors. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001619 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular, morphological and functional properties of tunnelling nanotubes between normal and cancer urothelial cells: New insights from the in vitro model mimicking the situation after surgical removal of the urothelial tumor. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-001657 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001767 SMASH-BIO | force_spectroscopy | study_record | in vitro Theoretical analysis of cargo transport by catch bonded motors in optical trapping assays · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001889 SMASH-BIO | force_spectroscopy | study_record | in vitro Dissecting Mechanoenzymatic Properties of Processive Myosins with Ultrafast Force-Clamp Spectroscopy. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001902 SMASH-BIO | force_spectroscopy | study_record | in vitro Effects of dynein inhibitor on the number of motor proteins transporting synaptic cargos. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-001984 SMASH-BIO | force_spectroscopy | study_record | in vitro Long-Range Electrostatic Interactions Significantly Modulate the Affinity of Dynein for Microtubules · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002048 SMASH-BIO | force_spectroscopy | study_record | in vitro On and off controls within dynein-dynactin on native cargoes. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002065 SMASH-BIO | force_spectroscopy | study_record | in vitro Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-002273 SMASH-BIO | force_spectroscopy | study_record | in vitro Collective Force Generation by Molecular Motors Is Determined by Strain-Induced Unbinding. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-002274 SMASH-BIO | force_spectroscopy | study_record | in vitro Collective intracellular cargo transport by multiple kinesins on multiple microtubules. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-002316 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Dynein Harnesses Active Fluctuations of Microtubules for Faster Movement. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-002322 SMASH-BIO | force_spectroscopy | study_record | in vitro Effects of the dynein inhibitor dynarrestin on the number of motor proteins transporting synaptic cargos · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-002360-r0 SMASH-BIO | force_spectroscopy | stall_force: 2 pN | in vitro · pH 7 Force production of human cytoplasmic dynein is limited by its processivity. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-002405 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6 Lis1 activates dynein motility by modulating its pairing with dynactin. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002423 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Mechanisms of Motor-Independent Membrane Remodeling Driven by Dynamic Microtubules. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-002579 SMASH-BIO | force_spectroscopy | study_record | in vitro The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-002580 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-002701 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynein activators and adaptors at a glance. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, membrane_mechanics, nucleic_acid_protein_interaction, rheology_cell | unmapped |
| EV-SMASH-SMFS-002769 SMASH-BIO | force_spectroscopy | study_record | in vitro Lis1 activates dynein motility by pairing it with dynactin · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002771 SMASH-BIO | force_spectroscopy | study_record | in vitro Load-dependent detachment kinetics plays a key role in bidirectional cargo transport by kinesin and dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-002772 SMASH-BIO | force_spectroscopy | study_record | in vitro MAP7 recruits kinesin-1 to microtubules to direct organelle transport · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization | unmapped |
| EV-SMASH-SMFS-002773 SMASH-BIO | force_spectroscopy | study_record | in vitro Magnetic manipulation of axonal endosome transport in live neurons · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002799 SMASH-BIO | force_spectroscopy | study_record | in vitro Mg2+ -free ATP regulates the processivity of native cytoplasmic dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-002808 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Molecular mechanism of cytoplasmic dynein tension sensing. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003033 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Coin Tossing Explains the Activity of Opposing Microtubule Motors on Phagosomes. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003036 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.8 Combining Structure-Function and Single-Molecule Studies on Cytoplasmic Dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003079 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynamic Clustering of Dyneins on Axonal Endosomes: Evidence from High-Speed Darkfield Imaging. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, membrane_mechanics | unmapped |
| EV-SMASH-SMFS-003086 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynein catch bond as a mediator of codependent bidirectional cellular transport · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003152 SMASH-BIO | force_spectroscopy | study_record | in vitro Kinesin and Dynein Mechanics: Measurement Methods and Research Applications. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-003226 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.9 Physical Forces Determining the Persistency and Centering Precision of Microtubule Asters. · Cytoplasmic dynein-1; magnetic tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003242-r0 SMASH-BIO | force_spectroscopy | stall_force: 1.1 pN | in vitro · pH 7.7 Processive Kinesin-14 HSET Exhibits Directional Flexibility Depending on Motor Traffic. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003314 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Step Sizes and Rate Constants of Single-headed Cytoplasmic Dynein Measured with Optical Tweezers. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003324 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-003326 SMASH-BIO | force_spectroscopy | study_record | in vitro Temporal cooperativity of motor proteins under constant force: insights from Kramers' escape problem. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003484 SMASH-BIO | force_spectroscopy | study_record | in vitro Effects of external strain on the regulation of microtubule sliding induced by outer arm dynein of sea urchin sperm flagella. · Cytoplasmic dynein-1; microneedle; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003573 SMASH-BIO | force_spectroscopy | study_record | in vitro Measuring Molecular Forces Using Calibrated Optical Tweezers in Living Cells. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-003630 SMASH-BIO | force_spectroscopy | study_record | in vitro Optical Tweezers-Based Measurements of Forces and Dynamics at Microtubule Ends. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, rheology_cell | unmapped |
| EV-SMASH-SMFS-003750 SMASH-BIO | force_spectroscopy | study_record | in vitro Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-003880 SMASH-BIO | force_spectroscopy | study_record | in vitro Effect of catch bonding on transport of cellular cargo by dynein motors. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003924 SMASH-BIO | force_spectroscopy | study_record | in vitro Importance of anisotropy in detachment rates for force production and cargo transport by a team of motor proteins. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003942 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Load-induced enhancement of Dynein force production by LIS1-NudE in vivo and in vitro. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004169 SMASH-BIO | force_spectroscopy | study_record | in vitro Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004191 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynein arms are strain-dependent direction-switching force generators. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004256 SMASH-BIO | force_spectroscopy | study_record | in vitro Intracellular and extracellular forces drive primary cilia movement. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004296 SMASH-BIO | force_spectroscopy | study_record | in vitro Model for bidirectional movement of cytoplasmic dynein. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004402 SMASH-BIO | force_spectroscopy | study_record | in vitro The Kinesin-8 Kip3 switches protofilaments in a sideward random walk asymmetrically biased by force. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004461 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 An improved optical tweezers assay for measuring the force generation of single kinesin molecules. · Cytoplasmic dynein-1; optical tweezers; experiment class: chromatin_mechanics, force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004503 SMASH-BIO | force_spectroscopy | study_record | in vitro Covalent immobilization of microtubules on glass surfaces for molecular motor force measurements and other single-molecule assays. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004504 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Cytoplasmic dynein transports cargos via load-sharing between the heads. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004679 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Reconstituting the motility of isolated intracellular cargoes. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, membrane_mechanics, nucleic_acid_protein_interaction, rheology_cell | unmapped |
| EV-SMASH-SMFS-004704 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule fluorescence and in vivo optical traps: how multiple dyneins and kinesins interact. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004739 SMASH-BIO | force_spectroscopy | study_record | in vitro The winch model can explain both coordinated and uncoordinated stepping of cytoplasmic dynein. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004824 SMASH-BIO | force_spectroscopy | study_record | in vitro Correction for Blehm et al., In vivo optical trapping indicates kinesin’s stall force is reduced by dynein during intracellular transport · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004886 SMASH-BIO | force_spectroscopy | study_record | in vitro In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-004905 SMASH-BIO | force_spectroscopy | study_record | in vitro Laser trap measurements of flagellar membrane motility. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004946 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular adaptations allow dynein to generate large collective forces inside cells. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004952 SMASH-BIO | force_spectroscopy | study_record | in vitro Motor domain phosphorylation modulates kinesin-1 transport. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-005144 SMASH-BIO | force_spectroscopy | study_record | in vitro Cooperative responses of multiple kinesins to variable and constant loads. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-005167 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Dynein tethers and stabilizes dynamic microtubule plus ends. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, rheology_cell | unmapped |
| EV-SMASH-SMFS-005176 SMASH-BIO | force_spectroscopy | study_record | in vitro Effectiveness of a dynein team in a tug of war helped by reduced load sensitivity of detachment: evidence from the study of bidirectional endosome transport in D. discoideum. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, membrane_mechanics, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005193 SMASH-BIO | force_spectroscopy | study_record | in vitro Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-005200 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-005240 SMASH-BIO | force_spectroscopy | study_record | in vitro Measuring molecular motor forces in vivo: implications for tug-of-war models of bidirectional transport. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005383 SMASH-BIO | force_spectroscopy | study_record | in vitro Two independent switches regulate cytoplasmic dynein's processivity and directionality. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-005451 SMASH-BIO | force_spectroscopy | study_record | in vitro Cargo transport by several motors. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, membrane_mechanics | unmapped |
| EV-SMASH-SMFS-005615 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing the force generation and stepping behavior of cytoplasmic Dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, nucleic_acid_protein_interaction, rheology_cell | unmapped |
| EV-SMASH-SMFS-005728 SMASH-BIO | force_spectroscopy | study_record | in vitro Bidirectional transport by molecular motors: enhanced processivity and response to external forces. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-005768 SMASH-BIO | force_spectroscopy | study_record | in vitro Direct physical study of kinetochore-microtubule interactions by reconstitution and interrogation with an optical force clamp. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006001 SMASH-BIO | force_spectroscopy | study_record | in vitro Biophysical measurements on axonemal dyneins. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006150 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing dynein and kinesin stepping with mechanical manipulation in a living cell. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006243 SMASH-BIO | force_spectroscopy | study_record | in vitro Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006502 SMASH-BIO | force_spectroscopy | study_record | in vitro Tuning microtubule-based transport through filamentous MAPs: the problem of dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006598-r1 SMASH-BIO | force_spectroscopy | stall_force: 7 pN | in vitro Force-induced bidirectional stepping of cytoplasmic dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, rheology_cell | unmapped |
| EV-SMASH-SMFS-006741-r0 SMASH-BIO | force_spectroscopy | step_size: 8 nm | in vitro A simple theoretical model explains dynein's response to load. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-006866-r0 SMASH-BIO | force_spectroscopy | velocity: 800 nm/s | in vitro Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-006866-r1 SMASH-BIO | force_spectroscopy | step_size: 8 nm | in vitro Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-006943 SMASH-BIO | force_spectroscopy | study_record | in vitro Analysis of force generation during flagellar assembly through optical trapping of free-swimming Chlamydomonas reinhardtii. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007038 SMASH-BIO | force_spectroscopy | study_record | in vitro Optically-controllable, micron-sized motor based on live cells. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007119-r0 SMASH-BIO | force_spectroscopy | step_size: 8 nm | in vitro Cytoplasmic dynein functions as a gear in response to load. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, rheology_cell | unmapped |
| EV-SMASH-SMFS-007135 SMASH-BIO | force_spectroscopy | study_record | in vitro Exploring molecular motors and switches at the single-molecule level. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007162 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular motors: Dynein's gearbox. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-007367 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanical Properties of a Single-Headed Processive Motor, Inner-Arm Dynein Subspecies-c of ChlamydomonasStudied at the Single Molecule Level. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007490 SMASH-BIO | force_spectroscopy | study_record | in vitro Measurement of the force produced by an intact bull sperm flagellum in isometric arrest and estimation of the dynein stall force. · Cytoplasmic dynein-1; force spectroscopy unspecified; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007506 SMASH-BIO | force_spectroscopy | study_record | in vitro Processive movement of single 22S dynein molecules occurs only at low ATP concentrations. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007552 SMASH-BIO | force_spectroscopy | study_record | in vitro Inner-arm dynein c of Chlamydomonas flagella is a single-headed processive motor. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007599 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynein arms are oscillating force generators. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007674 SMASH-BIO | force_spectroscopy | study_record | in vitro Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, membrane_mechanics, rheology_cell | unmapped |
| EV-SMASH-SMFS-007699 SMASH-BIO | force_spectroscopy | study_record | in vitro Force generation of organelle transport measured in vivo by an infrared laser trap. · Cytoplasmic dynein-1; optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
Conflicts
No conflicts found among comparable evidence.
210 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.