TAR DNA-binding protein 43
UniProt Q13148 · gene TARDBP · Homo sapiens · 414 residues
69evidence items
0mapped to a state
0states
9techniques
6sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | microed | nmr_structure | nmr_shifts | saxs_sans | cd | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|
| No states defined yet. | |||||||||||
Unmapped evidence: 69 of 69 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 13 | 0 |
| DisProt | 6 | 0 |
| RCSB PDB | 46 | 0 |
| SASBDB | 2 | 0 |
| SMASH-BIO | 1 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1WF0-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Solution structure of RRM domain in TAR DNA-binding protein-43 · TAR DNA-binding protein-43 (chains A) | unmapped |
| EV-PDB-2CQG-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Solution structure of the RNA binding domain of TAR DNA-binding protein-43 · TAR DNA-binding protein-43 (chains A) | unmapped |
| EV-PDB-2N2C-1 RCSB PDB | nmr_structure | structure | in vitro · 39.85 °C · pH 4 NMR Structure of TDP-43 prion-like hydrophobic helix in DPC · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-2N3X-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of TDP-43 Amyloidogenic Core Region · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-2N4G-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of the G335D Mutant of TDP-43 Amyloidogenic Core Region · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-2N4H-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-2N4P-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 3.8 Solution structure of the n-terminal domain of tdp-43 · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-4BS2-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.8 NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA · TAR DNA-BINDING PROTEIN 43 (chains A) | unmapped |
| EV-PDB-4IUF-1 RCSB PDB | xray | resolution: 2.752 Å | in vitro · -163.15 °C · pH 5.5 Crystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-4Y00-1 RCSB PDB | xray | resolution: 3 Å | in vitro · -163.15 °C · pH 7.5 Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA · TAR DNA-binding protein 43 (chains A,B,C,D) | unmapped |
| EV-PDB-4Y0F-1 RCSB PDB | xray | resolution: 2.648 Å | in vitro · -163.15 °C Crystal Structure of Human TDP-43 RRM1 Domain in Complex with an Unmodified Single-stranded DNA · TAR DNA-binding protein 43 (chains A,B) | unmapped |
| EV-PDB-5MDI-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands ACT Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution · TAR DNA-binding protein 43 (chains A,B) | unmapped |
| EV-PDB-5MRG-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 3.9 Solution structure of TDP-43 (residues 1-102) · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-5W50-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 9.5 Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253 · TAR DNA-binding protein 43 (chains A,B) | unmapped |
| EV-PDB-5W52-1 RCSB PDB | microed | resolution: 1.4 Å | in vitro · -173.15 °C · pH 8.5 MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257 · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-5W7V-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro CryoEM structure of the segment, DLIIKGISVHI, assembled into a triple-helical fibril · TAR DNA-binding protein 43 (chains 0,1,2,3,4,5,6,7,8) | unmapped |
| EV-PDB-5WHN-1 RCSB PDB | xray | resolution: 1.1 Å | in vitro · -173.15 °C · pH 4.2 Crystal structure of the segment, NFGAFS, from the low complexity domain of TDP-43, residues 312-317 · Segment of TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-5WHP-1 RCSB PDB | xray | resolution: 1 Å | in vitro · -173.15 °C · pH 4.6 Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low complexity domain of TDP-43, residues 312-317 · Segment of TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-5WIA-1 RCSB PDB | xray | resolution: 1.002 Å | in vitro · -173.15 °C · pH 8.5 Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43, residues 370-375 · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-5WIQ-1 RCSB PDB | xray | resolution: 1.25 Å | in vitro · -173.15 °C · pH 4.5 Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43, residues 396-402 · TAR DNA-binding protein 43 (chains A,B) | unmapped |
| EV-PDB-5WKB-1 RCSB PDB | microed | resolution: 1 Å | in vitro · -173.15 °C · pH 7.5 MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-5WKD-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306 · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-5X4F-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of the N-terminal Domain of TDP-43 · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-6B1G-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.8 Solution structure of TDP-43 N-terminal domain dimer. · TAR DNA-binding protein 43, S48E Mutant (chains A) | unmapped |
| EV-PDB-6B1G-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.8 Solution structure of TDP-43 N-terminal domain dimer. · TAR DNA-binding protein 43, Y4R Mutant (chains B) | unmapped |
| EV-PDB-6CF4-1 RCSB PDB | microed | resolution: 0.75 Å | in vitro · -173.15 °C · pH 7.5 Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low complexity domain of TDP-43, residues 312-317 · NFGTFS (chains A) | unmapped |
| EV-PDB-6CFH-1 RCSB PDB | microed | resolution: 1.5 Å | in vitro · -173.15 °C · pH 7.5 SWGMMGMLASQ segment from the low complexity domain of TDP-43 · TAR DNA-binding protein 43 (chains A,B) | unmapped |
| EV-PDB-6N37-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro SegA-sym, conformation of TDP-43 low complexity domain segment A sym · TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-6N3A-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro SegA-long, conformation of TDP-43 low complexity domain segment A long · TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-6N3A-2 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro SegA-long, conformation of TDP-43 low complexity domain segment A long · segA long small (chains K,L,M,N,O,P,Q,R,S,T) | unmapped |
| EV-PDB-6N3B-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro SegA-asym, conformation of TDP-43 low complexity domain segment A asym · TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-6N3C-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro SegB, conformation of TDP-43 low complexity domain segment A · TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T) | unmapped |
| EV-PDB-6T4B-1 RCSB PDB | xray | resolution: 2.55 Å | in vitro · -173.15 °C · pH 6.5 · ligands SO4 CRYSTAL STRUCTURE OF HUMAN TDP-43 N-TERMINAL DOMAIN AT 2.55 A RESOLUTION · TAR DNA-binding protein 43 (chains A,C,E,G,I) | unmapped |
| EV-PDB-7KWZ-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro TDP-43 LCD amyloid fibrils · Isoform 2 of TAR DNA-binding protein 43 (chains A,B,C,D,E) | unmapped |
| EV-PDB-7N9H-2 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 5.6 Structure of the mammalian importin a1 bound to the TDP-43 NLS · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-7PY2-1 RCSB PDB | cryoem | resolution: 2.59 Å | in vitro Structure of pathological TDP-43 filaments from ALS with FTLD · TAR DNA-binding protein 43 (chains A,B,C,D) | unmapped |
| EV-PDB-7Q3U-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro Cryo-EM structure of TDP43 core peptide amyloid fiber · TAR DNA-binding protein 43 (chains A,B,C,D,E) | unmapped |
| EV-PDB-8A6I-1 RCSB PDB | nmr_structure | structure | in vitro · 14.85 °C · pH 6.8 Structure of the low complexity domain of TDP-43 (fragment 309-350) with methionine sulfoxide modifications · TAR DNA-binding protein 43 (chains A) | unmapped |
| EV-PDB-8CG3-1 RCSB PDB | cryoem | resolution: 2.39 Å | in vitro Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 1) · TAR DNA-binding protein 43 (chains A,B,C,D,U) | unmapped |
| EV-PDB-8CGG-1 RCSB PDB | cryoem | resolution: 2.5 Å | in vitro Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 2) · TAR DNA-binding protein 43 (chains A,B,C,D,U) | unmapped |
| EV-PDB-8CGH-1 RCSB PDB | cryoem | resolution: 2.68 Å | in vitro Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 3) · TAR DNA-binding protein 43 (chains A,B,C,D,U) | unmapped |
| EV-PDB-8QX9-1 RCSB PDB | cryoem | resolution: 3.76 Å | in vitro TDP-43 amyloid fibrils: Morphology-1a · TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-8QXA-1 RCSB PDB | cryoem | resolution: 4.05 Å | in vitro TDP-43 amyloid fibrils: Morphology-1b · TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-8QXB-1 RCSB PDB | cryoem | resolution: 3.86 Å | in vitro TDP-43 amyloid fibrils: Morphology-2 · TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R) | unmapped |
| EV-PDB-9FOF-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 2) · TAR DNA-binding protein 43 (chains A,C,E,G,I,q) | unmapped |
| EV-PDB-9FOR-1 RCSB PDB | cryoem | resolution: 2.75 Å | in vitro Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 1) · TAR DNA-binding protein 43 (chains A,C,E,G,o) | unmapped |
| EV-BMRB-18765 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.6 Backbone and side-chain assignments of 1H, 15N and 13C chemical shifts of RNA recognition motif 1 (RRM1) of TAR DNA-binding protein (TDP-43) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-19290 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.8 NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts, 31P chemical shifts | unmapped |
| EV-BMRB-19922 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.7 Backbone 1H, 13C, and 15N Chemical Shift Assignments of human TDP-43 RRM2 · BMRB data: 13C chemical shifts, 1H chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-25595 BMRB | nmr_shifts | chemical_shift | in vitro · 39.85 °C · pH 4 NMR Structure of TDP-43 prion-like hydrophobic helix in DPC · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25659 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 6.5 Solution Structure of TDP-43 Amyloidogenic Core Region · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25667 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 6.5 Solution Structure of the G335D Mutant of TDP-43 Amyloidogenic Core Region · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25668 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 6.5 Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25675 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 3.8 SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF TDP-43 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30345 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.8 Solution structure of TDP-43 N-terminal domain dimer. · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34081 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 3.9 Solution structure of TDP-43 (residues 1-102) · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34737 BMRB | nmr_shifts | chemical_shift | in vitro · 14.85 °C · pH 6.8 Structure of the low complexity domain of TDP-43 (fragment 309-350) with methionine sulfoxide modifications · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36060 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Solution Structure of the N-terminal Domain of TDP-43 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-51494 BMRB | nmr_shifts | chemical_shift | in vitro · 14.85 °C · pH 6.8 Backbone 1H, 13C, and 15N Chemical Shift Assignments for TDP-43 low complexity domain with methionine sulfoxide modifications · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-SASBDB-SASDV74 SASBDB | saxs_sans | radius_of_gyration: 1.418 nm ± 0.059 | in vitro · 20 °C · pH 8.5 Semi-synthesis of TDP-43 reveals the effects of phosphorylation in N-terminal domain on self-association · TAR DNA-binding protein 43 | unmapped |
| EV-SASBDB-SASDXL8 SASBDB | saxs_sans | radius_of_gyration: 3.98 nm ± 0.261 | in vitro · 25 °C · pH 7.6 From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach. · TAR DNA-binding protein 43 | unmapped |
| EV-DISPROT-DP01108r001 DisProt | nmr_shifts | disorder_region: 149 residues | in vitro DisProt DP01108: disorder, residues 266-414 · residues 266-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01108r005 DisProt | nmr_shifts | disorder_region: 148 residues | in vitro DisProt DP01108: disorder, residues 267-414 · residues 267-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01108r013 DisProt | cd | disorder_region: 152 residues | in vitro DisProt DP01108: disorder, residues 263-414 · residues 263-414; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01108r014 DisProt | nmr_shifts | disorder_region: 152 residues | in vitro DisProt DP01108: disorder, residues 263-414 · residues 263-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01108r020 DisProt | cd | disorder_region: 152 residues | in vitro DisProt DP01108: disorder to order, residues 263-414 · residues 263-414; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01108r023 DisProt | nmr_shifts | disorder_region: 152 residues | in vitro DisProt DP01108: disorder to order, residues 263-414 · residues 263-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-AFDB-AF-Q13148-F1 AlphaFold DB | af_prediction | plddt: 65.19 pLDDT | in silico AlphaFold DB prediction AF-Q13148-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-414 | unmapped |
| EV-SMASH-SMFS-003053-r0 SMASH-BIO | force_spectroscopy | unfolding_force: 40 pN | in vitro DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43. · TDP-43; afm smfs; experiment class: nucleic_acid_protein_interaction, unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
67 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.