Focal adhesion kinase 1
UniProt Q05397 · gene PTK2 · Homo sapiens · 1052 residues
57evidence items
0mapped to a state
0states
5techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_shifts | force_spectroscopy | integrative | af_prediction | Total |
|---|---|---|---|---|---|---|---|
| No states defined yet. | |||||||
Unmapped evidence: 57 of 57 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 1 | 0 |
| DisProt | 1 | 0 |
| RCSB PDB | 41 | 0 |
| SMASH-BIO | 13 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1MP8-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 5 · ligands ADP Crystal structure of Focal Adhesion Kinase (FAK) · focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-4KAB-1 RCSB PDB | xray | resolution: 2.71 Å | in vitro · -173.15 °C · pH 6 · ligands 4KA FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 3-Methyl-1,4-dihydro-pyrazolo[4,5-c]pyrazole · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-6I8Z-1 RCSB PDB | xray | resolution: 1.99 Å | in vitro · -173.15 °C · pH 6 · ligands H82 Crystal structure of PTK2 in complex with BI-4464. · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-6LES-1 RCSB PDB | xray | resolution: 2.004 Å | in vitro · -173.15 °C · pH 10.5 · ligands SO4 3D domain-swapped dimer of the maltose-binding protein fused to a fragment of the focal adhesion kinase · Maltose/maltodextrin-binding periplasmic protein,Focal adhesion kinase 1 (chains A,B,X,Y) | unmapped |
| EV-PDB-6YR9-1 RCSB PDB | xray | resolution: 1.925 Å | in vitro · -173.15 °C · pH 7.5 · ligands P9K FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide · Focal adhesion kinase 1 (chains A,B,C,D) | unmapped |
| EV-PDB-6YVS-1 RCSB PDB | xray | resolution: 1.81 Å | in vitro · -173.15 °C · pH 7.5 · ligands PVT, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 5-{4-[(Pyridin-3-ylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one · Focal adhesion kinase 1 (chains A,B,C,D) | unmapped |
| EV-PDB-6YVY-1 RCSB PDB | xray | resolution: 1.918 Å | in vitro · -173.15 °C · pH 7.5 · ligands P1E, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide · Focal adhesion kinase 1 (chains A,B,C,D) | unmapped |
| EV-PDB-6YXV-1 RCSB PDB | xray | resolution: 2.298 Å | in vitro · -173.15 °C · ligands Q2H, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-{3-[(2-phenylamino-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl]-pyridin-2-yl}-methanesulfonamide · Focal adhesion kinase 1 (chains A,B,C,D) | unmapped |
| EV-PDB-7PI4-4 RCSB PDB | xray | resolution: 2.24 Å | in vitro · -173.15 °C · ligands 7QB, CA, EDO, PEG FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB · Focal adhesion kinase 1 (chains DDD) | unmapped |
| EV-PDB-9SDI-1 RCSB PDB | xray | resolution: 2.53 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1JNJ, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-(1H-Pyrazol-4-yl)-nicotinic acid · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-9A8R-1 RCSB PDB | integrative | structure | in vitro Integrative structure of focal adhesion kinase 1 from NMR data · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-7W9U-1 RCSB PDB | xray | resolution: 2.163 Å | in vitro · -173.15 °C · ligands ZN Crystal Structure of Zn bound human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Isoform 5 of Focal adhesion kinase 1 (chains A,B,C,D) | unmapped |
| EV-PDB-7W8I-1 RCSB PDB | xray | resolution: 1.943 Å | in vitro · -173.15 °C · ligands ZN Crystal structure of Zn bound human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Isoform 5 of Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-7W8B-1 RCSB PDB | xray | resolution: 2.093 Å | in vitro · -173.15 °C · pH 8 Crystal Structure of human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Isoform 5 of Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-7W7Z-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · pH 6.5 Crystal Structure of human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Isoform 5 of Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-6YT6-1 RCSB PDB | xray | resolution: 1.537 Å | in vitro · -173.15 °C · pH 9 · ligands PKE, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-6YQ1-1 RCSB PDB | xray | resolution: 1.784 Å | in vitro · -173.15 °C · pH 7.5 · ligands NA, P7N, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide · Focal adhesion kinase 1 (chains A,B,C,D) | unmapped |
| EV-PDB-6YOJ-1 RCSB PDB | xray | resolution: 1.361 Å | in vitro · -173.15 °C · ligands P4N FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-6PW8-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · 19.85 °C · ligands CL, ZN Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (FAT) Domain of the Focal Adhesion Kinase (FAK) · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-4Q9S-1 RCSB PDB | xray | resolution: 2.07 Å | in vitro · -73.15 °C · pH 5.6 · ligands 30G Crystal Structure of human Focal Adhesion Kinase (Fak) bound to Compound1 (3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE) · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-4NY0-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 5.5 Crystal structure of FERM domain of human focal adhesion kinase · Focal adhesion kinase 1 (chains A,B,C,D) | unmapped |
| EV-PDB-4KAO-1 RCSB PDB | xray | resolution: 2.39 Å | in vitro · -173.15 °C · pH 9 · ligands KAO, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-4K9Y-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7.5 · ligands K9Y FOCAL ADHESION KINASE Catalytic domain in complex with 1-[4-(6-Amino-purin-9-yl)-phenyl]-3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-urea · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-4K8A-1 RCSB PDB | xray | resolution: 2.91 Å | in vitro · -173.15 °C · pH 6 · ligands K8A Fragment-based discovery of Focal Adhesion Kinase Inhibitors · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-4I4F-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 7.5 · ligands 1BR, IPA Structure of Focal Adhesion Kinase catalytic domain in complex with an allosteric binding pyrazolobenzothiazine compound. · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-4I4E-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 7.5 · ligands 1BQ Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound. · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-4GU9-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 8.6 · ligands 4GU Focal adhesion kinase catalytic domain in complex with (2-Fluoro-phenyl)-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-4GU6-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 8.6 · ligands 10N FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-{3-[(5-Cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)- methyl]-pyridin-2-yl}-N-methyl-methanesulfonamide · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-4EBW-1 RCSB PDB | xray | resolution: 2.65 Å | in vitro · pH 7.5 · ligands 0PF Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-4EBV-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · pH 7.5 · ligands 0O7, IPA Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-3S9O-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 7 · ligands CL, NA The Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase showing N-terminal interactions in cis · Focal adhesion kinase 1 (chains A,B,C) | unmapped |
| EV-PDB-3PXK-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 8.6 · ligands PXK, SO4 FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH Pyrrolo[2,3-d]thiazole · PTK2 protein (chains A,B) | unmapped |
| EV-PDB-3BZ3-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 7.5 · ligands YAM Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor · Focal adhesion kinase 1 (chains A) | unmapped |
| EV-PDB-3B71-1 RCSB PDB | xray | resolution: 2.82 Å | in vitro · -173.15 °C · pH 6.5 CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Focal adhesion kinase 1 (chains A,B,C) | unmapped |
| EV-PDB-2IJM-1 RCSB PDB | xray | resolution: 2.187 Å | in vitro · -73.15 °C · pH 7.5 · ligands ADP, ATP Crystal Structure of Focal Adhesion Kinase Domain with 2 molecules in the Asymmetric Unit Complexed with ADP and ATP · Focal Adhesion Kinase 1 (chains A,B) | unmapped |
| EV-PDB-2ETM-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -73.15 °C · pH 7.5 · ligands 7PY Crystal Structure of Focal Adhesion Kinase Domain Complexed with 7H-Pyrrolo [2,3-d] pyrimidine Derivative · Focal adhesion kinase 1 (chains A,B) | unmapped |
| EV-PDB-1OW8-1 RCSB PDB | xray | resolution: 2.85 Å | in vitro · -173.15 °C · pH 6.3 Paxillin LD2 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Focal adhesion kinase 1 (chains A,B,C) | unmapped |
| EV-PDB-1OW7-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 6.3 Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Focal adhesion kinase 1 (chains A,B,C) | unmapped |
| EV-PDB-1OW6-1 RCSB PDB | xray | resolution: 2.35 Å | in vitro · -173.15 °C · pH 6.3 Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase · Focal adhesion kinase 1 (chains A,B,C) | unmapped |
| EV-PDB-1K05-1 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -173.15 °C · pH 7 Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase · FOCAL ADHESION KINASE 1 (chains A,B,C) | unmapped |
| EV-PDB-1K04-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 6.5 · ligands CL Crystal Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase · FOCAL ADHESION KINASE 1 (chains A) | unmapped |
| EV-BMRB-28012 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Backbone resonance assignments for Human Focal Adhesion Targeting domain (892-1052) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-DISPROT-DP03144r001 DisProt | xray | disorder_region: 19 residues | in vitro DisProt DP03144: disorder, residues 565-583 · residues 565-583; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-AFDB-AF-Q05397-F1 AlphaFold DB | af_prediction | plddt: 74.5 pLDDT | in silico AlphaFold DB prediction AF-Q05397-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-1052 | unmapped |
| EV-SMASH-SMFS-000173 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.6 Matrix Mechanics Governs Mechano-Metabolic Adaptation across Cancer Grades in Bladder Spheroids. · FAK; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-000188 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanobiology of the diabetic cardiomyocyte: insulin signaling, titin elasticity, and multiscale mechanical dysfunction. · FAK; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-000489 SMASH-BIO | force_spectroscopy | study_record | in vitro Load-dependent RGD-context sensing via αV-class integrin reprograms cellular adhesion and mechanics within seconds · FAK; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001712 SMASH-BIO | force_spectroscopy | study_record | in cell Single-Molecule Force Imaging Reveals That Podosome Formation Requires No Extracellular Integrin-Ligand Tensions or Interactions. · FAK; tension sensors; experiment class: force_generation_motor, force_generation_polymerization, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002836 SMASH-BIO | force_spectroscopy | study_record | in vitro Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy. · FAK; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002916 SMASH-BIO | force_spectroscopy | study_record | in vitro Structural and mechanistic insights into mechanoactivation of focal adhesion kinase. · FAK; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003508 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices. · FAK; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005060 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 The focal adhesion: a regulated component of aortic stiffness. · FAK; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005500 SMASH-BIO | force_spectroscopy | study_record | in vitro Focal adhesion kinase stabilizes the cytoskeleton. · FAK; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005949 SMASH-BIO | force_spectroscopy | study_record | in vitro The influence of Pyk2 on the mechanical properties in fibroblasts. · FAK; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-006009 SMASH-BIO | force_spectroscopy | study_record | in vitro Comparing the mechanical influence of vinculin, focal adhesion kinase and p53 in mouse embryonic fibroblasts. · FAK; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007050-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 600 nN | in vitro Quantitative measurement of changes in adhesion force involving focal adhesion kinase during cell attachment, spread, and migration. · FAK; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007259 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. · FAK; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
Conflicts
No conflicts found among comparable evidence.
57 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.