Cytochrome c
UniProt P99999 · gene CYCS · Homo sapiens · 105 residues
32evidence items
0mapped to a state
0states
6techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_structure | nmr_shifts | saxs_sans | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 32 of 32 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 7 | 0 |
| RCSB PDB | 13 | 0 |
| SASBDB | 1 | 0 |
| SMASH-BIO | 10 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1J3S-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 6.5 · ligands HEC Solution Structure of Reduced Recombinant Human Cytochrome c · Cytochrome c (chains A) | unmapped |
| EV-PDB-2N3Y-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.3 · ligands MH0 NMR structure of the Y48pCMF variant of human cytochrome c in its reduced state · Cytochrome c (chains A) | unmapped |
| EV-PDB-2N9I-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.8 · ligands HEC Solution structure of reduced human cytochrome c · Cytochrome c (chains A) | unmapped |
| EV-PDB-2N9J-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.8 · ligands HEC Solution structure of oxidized human cytochrome c · Cytochrome c (chains A) | unmapped |
| EV-PDB-3NWV-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -180.15 °C · pH 7 · ligands HEC Human cytochrome c G41S · Cytochrome c (chains A,B,C,D) | unmapped |
| EV-PDB-3ZCF-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 7 · ligands HEC Structure of recombinant human cytochrome c · CYTOCHROME C (chains A,B,C,D) | unmapped |
| EV-PDB-3ZOO-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 7 · ligands HEC, PO4 Structure of the Y46F mutant of human cytochrome c · CYTOCHROME C (chains A,B,C,D) | unmapped |
| EV-PDB-5EXQ-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -180.15 °C · pH 8.5 · ligands HEC, SO4 Human cytochrome c Y48H · Cytochrome c (chains A,B) | unmapped |
| EV-PDB-5O10-1 RCSB PDB | xray | resolution: 1.36 Å | in vitro · -173.15 °C · pH 7.5 · ligands HEC Y48H mutant of human cytochrome c · Cytochrome c (chains A,B) | unmapped |
| EV-PDB-5TY3-1 RCSB PDB | xray | resolution: 1.25 Å | in vitro · -173.15 °C · pH 8 · ligands HEC, SO4 Crystal structure of K72A variant of Human Cytochrome c · Cytochrome c (chains A,B) | unmapped |
| EV-PDB-6DUJ-1 RCSB PDB | xray | resolution: 1.82203 Å | in vitro · -173.15 °C · ligands HEC Crystal structure of A51V variant of Human Cytochrome c · Cytochrome c (chains A,C) | unmapped |
| EV-PDB-6ECJ-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -180.15 °C · pH 8.5 · ligands HEC Human cytochrome c G41T · Cytochrome c (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-6XNK-1 RCSB PDB | xray | resolution: 2.08 Å | in vitro · -173.15 °C · pH 9.9 · ligands HEC Crystal structure of dimeric K72A human cytochrome c alkaline conformer · Cytochrome c (chains A,C,E,G) | unmapped |
| EV-BMRB-25418 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 6.8 Human Cytochrome c WT ferric form (oxidized) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25420 BMRB | nmr_shifts | chemical_shift | in vitro · 14.85 °C · pH 6.8 Backbone 1H, 13C, and 15N Chemical Shift Assignments for the ferrous form of the G41S mutant of Human Cytochrome c · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25422 BMRB | nmr_shifts | chemical_shift | in vitro · 14.85 °C · pH 6.8 Backbone 1H, 13C, and 15N Chemical Shift Assignments for the ferric form of the G41S mutant of Human Cytochrome c · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25660 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.3 NMR structure of the Y48pCMF variant of human cytochrome c in its reduced state · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25907 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.8 solution structure of reduced human cytochrome c · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25908 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.8 Solution structure of oxidized human cytochrome c · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-26578 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.3 NMR Assignment of Homo sapiens cytochrome c in its oxidized state · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-SASBDB-SASDN87 SASBDB | saxs_sans | radius_of_gyration: 4.2 nm ± 0.063 | in vitro · 10 °C · pH 6.3 · ligands partner: SET nuclear proto-oncogene PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iβ · Cytochrome c with SET nuclear proto-oncogene | unmapped |
| EV-AFDB-AF-P99999-F1 AlphaFold DB | af_prediction | plddt: 97.94 pLDDT | in silico AlphaFold DB prediction AF-P99999-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-105 | unmapped |
| EV-SMASH-SMFS-000972 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells. · Cytochrome c; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001347 SMASH-BIO | force_spectroscopy | study_record | in vitro Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells · Cytochrome c; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001351 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 The Histone Chaperones SET/TAF-1β and NPM1 Exhibit Conserved Functionality in Nucleosome Remodeling and Histone Eviction in a Cytochrome c-Dependent Manner. · Cytochrome c; optical tweezers; experiment class: chromatin_mechanics, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001640 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 New insights into the folding-unfolding mechanism and conformations of cytochrome C. · Cytochrome c; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005106 SMASH-BIO | force_spectroscopy | study_record | in vitro An efficient method for enzyme immobilization evidenced by atomic force microscopy. · Cytochrome c; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005464 SMASH-BIO | force_spectroscopy | study_record | in vitro Cytochrome c provokes the weakening of zwitterionic membranes as measured by force spectroscopy. · Cytochrome c; force spectroscopy unspecified; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005666 SMASH-BIO | force_spectroscopy | study_record | in vitro Steered molecular dynamics simulations of the electron transfer complex between azurin and cytochrome c551. · Cytochrome c; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006865 SMASH-BIO | force_spectroscopy | study_record | in vitro Optimized biorecognition of cytochrome c 551 and azurin immobilized on thiol-terminated monolayers assembled on Au(111) substrates. · Cytochrome c; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007061-r0 SMASH-BIO | force_spectroscopy | unbinding_force: 95 pN | in vitro Single molecule recognition between cytochrome C 551 and gold-immobilized azurin by force spectroscopy. · Cytochrome c; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007118 SMASH-BIO | force_spectroscopy | study_record | in vitro Cytochrome c adsorption to supported, anionic lipid bilayers studied via atomic force microscopy. · Cytochrome c; force spectroscopy unspecified; experiment class: membrane_mechanics | unmapped |
Conflicts
No conflicts found among comparable evidence.
31 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.