Peptidyl-prolyl cis-trans isomerase A
UniProt P62937 · gene PPIA · Homo sapiens · 165 residues
215evidence items
204mapped to a state
2states
7techniques
4sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | microed | nmr_structure | nmr_shifts | af_prediction | md | Total |
|---|---|---|---|---|---|---|---|---|---|
| major (ground) state CypA-major | observed | proc 190 | proc 8 | · | proc 6 | · | · | · | 204 |
| minor (excited) state CypA-minor | inferred | · | · | · | · | · | · | · | 0 |
Unmapped evidence: 11 of 215 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 8 | 0 |
| MDDB | 1 | 0 |
| RCSB PDB | 205 | 204 |
Curated rules applied
cypa-structures-major: 203 items
Structure
Choose a state. Each model is badged observed or inferred; assumptions are one click away.
States and transitions
| State | Basis | Parent | Description |
|---|---|---|---|
| major (ground) state CypA-major | observed | — | Ground-state fold; the room-temperature structure 3K0N also models alternative side-chain conformers. |
| minor (excited) state CypA-minor | inferred | — | Low-population state exchanging with the ground state on the catalytic timescale, seen by NMR relaxation dispersion.Assumptions (2)
|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1AK4-1 RCSB PDB | xray | resolution: 2.36 Å | in vitro · -173.15 °C · pH 7 HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID · CYCLOPHILIN A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1AWQ-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 8.4 CYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER) · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1AWR-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 8.4 CYPA COMPLEXED WITH HAGPIA · CYCLOPHILIN A (chains A,B,C,D,E,F) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1AWS-1 RCSB PDB | xray | resolution: 2.55 Å | in vitro · -173.15 °C · pH 8.4 SECYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER) · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1AWT-1 RCSB PDB | xray | resolution: 2.55 Å | in vitro · -173.15 °C · pH 8.4 SECYPA COMPLEXED WITH HAGPIA · CYCLOPHILIN A (chains A,B,C,D,E,F) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1AWU-1 RCSB PDB | xray | resolution: 2.34 Å | in vitro · -173.15 °C · pH 8.4 CYPA COMPLEXED WITH HVGPIA (PSEUDO-SYMMETRIC MONOMER) · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1AWV-1 RCSB PDB | xray | resolution: 2.34 Å | in vitro · -173.15 °C · pH 8.4 CYPA COMPLEXED WITH HVGPIA · CYCLOPHILIN A (chains A,B,C,D,E,F) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1BCK-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 8 HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWA-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWB-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWC-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWF-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWH-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · 19.85 °C · pH 8 HUMAN CYCLOPHILIN A COMPLEXED WITH 3-D-SER CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWJ-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 8 HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWK-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 8 HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWL-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 8 HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWM-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 19.85 °C · pH 8 HUMAN CYCLOPHILIN A COMPLEXED WITH 4 MEILE CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWO-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · 19.85 °C · pH 8.2 HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1FGL-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro Cyclophilin A complexed with a fragment of HIV-1 GAG protein · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1M63-3 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 6.5 · ligands CA, FE, ZN Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains C,G) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1M9C-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex. · Cyclophilin A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1M9D-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8.5 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex. · Cyclophilin A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1M9E-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · pH 8 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. · Cyclophilin A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1M9F-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 8.5 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex. · Cyclophilin A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1M9X-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8.5 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. · Cyclophilin A (chains A,B,E,F) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1M9Y-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8.5 X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. · Cyclophilin A (chains A,B,E,F) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1MF8-3 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -173.15 °C · pH 4.6 · ligands CA, PO4 Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains C) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1MIK-1 RCSB PDB | xray | resolution: 1.76 Å | in vitro THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1OCA-1 RCSB PDB | nmr_structure | structure | in vitro · 25.85 °C · pH 6.5 HUMAN CYCLOPHILIN A, UNLIGATED, NMR, 20 STRUCTURES · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1RMH-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro RECOMBINANT CYCLOPHILIN A FROM HUMAN T CELL · CYCLOPHILIN A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1VBT-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -99.15 °C · pH 8.2 Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF · CYCLOPHILIN A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1W8L-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands 1P3 Enzymatic and structural characterization of non peptide ligand cyclophilin complexes · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1W8M-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8 · ligands E1P Enzymatic and Structural Characterisation of Non Peptide Ligand Cyclophilin Complexes · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1W8V-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 Enzymatic and structural characterization of non peptide ligand cyclophilin complexes · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1ZKF-1 RCSB PDB | xray | resolution: 2.55 Å | in vitro · 24.85 °C · pH 8.2 Cyrstal Structure of Human Cyclophilin-A in Complex with suc-AGPF-pNA · Peptidyl-prolyl cis-trans isomerase A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2ALF-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8.5 · ligands MG crystal structure of human CypA mutant K131A · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2CPL-1 RCSB PDB | xray | resolution: 1.63 Å | in vitro SIMILARITIES AND DIFFERENCES BETWEEN HUMAN CYCLOPHILIN A AND OTHER BETA-BARREL STRUCTURES. STRUCTURAL REFINEMENT AT 1.63 ANGSTROMS RESOLUTION · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2MS4-1 RCSB PDB | nmr_structure | structure | in vitro · 31.85 °C · pH 6.8 Cyclophilin a complexed with a fragment of crk-ii · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2MZU-1 RCSB PDB | nmr_structure | structure | in vitro · 25.85 °C · pH 6.5 Extending the eNOE data set of large proteins by evaluation of NOEs with unresolved diagonals · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2N0T-1 RCSB PDB | nmr_structure | structure | in vitro · -247.15 °C · pH 6.5 Structural ensemble of the enzyme cyclophilin reveals an orchestrated mode of action at atomic resolution · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2RMA-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (chains A,C,E,G,I,K,M,O,Q,S) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2RMB-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (chains A,C,E,G,I,K,M,O,Q,S) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2X25-1 RCSB PDB | xray | resolution: 1.2 Å | in vitro · 13.85 °C Free acetyl-CypA orthorhombic form · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2X2A-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · 13.85 °C · ligands GOL, SO4 Free acetyl-CypA trigonal form · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2X2C-2 RCSB PDB | xray | resolution: 2.41 Å | in vitro · 13.85 °C acetyl-CypA:cyclosporine complex · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains K,M,O,Q,S) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2CYH-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · ligands ALA, PRO CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1YND-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · 19.85 °C · pH 6.5 · ligands SFA Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution · Peptidyl-prolyl cis-trans isomerase A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1VBS-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -99.15 °C · pH 8.2 STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1NMK-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 19.85 °C · pH 7 · ligands SFM The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data · Peptidyl-prolyl cis-trans isomerase A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-1CWI-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 8 HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2X2D-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C acetyl-CypA:HIV-1 N-term capsid domain complex · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains B,C) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-2XGY-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL Complex of Rabbit Endogenous Lentivirus (RELIK)Capsid with Cyclophilin A · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-36OI-2 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · ligands A1AOL, GNP, MG Tri-complex of Compound 1, KRAS G13C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-36OJ-2 RCSB PDB | xray | resolution: 1.74 Å | in vitro · -173.15 °C · ligands A1DKX, CL, GNP, MG, PEG Tri-complex of Compound 2, KRAS G13C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-36OK-2 RCSB PDB | xray | resolution: 1.21 Å | in vitro · -173.15 °C · ligands A1DKY, CL, GNP, MG, PEG Tri-complex of RMC-8839, KRAS G13C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3CYH-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · ligands PRO, SER CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE SER-PRO · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3CYS-1 RCSB PDB | nmr_structure | structure | in vitro DETERMINATION OF THE NMR SOLUTION STRUCTURE OF THE CYCLOPHILIN A-CYCLOSPORIN A COMPLEX · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3K0M-1 RCSB PDB | xray | resolution: 1.25 Å | in vitro · -173.15 °C · pH 7.5 Cryogenic structure of CypA · Cyclophilin A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3K0N-1 RCSB PDB | xray | resolution: 1.391 Å | in vitro · 14.85 °C · pH 7.5 Room temperature structure of CypA · Cyclophilin A (chains A) | major (ground) state · curator:draft (unreviewed) · high Room-temperature structure of CypA. |
| EV-PDB-3K0O-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · 14.85 °C · pH 7 Room temperature structure of CypA mutant Ser99Thr · Cyclophilin A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3K0P-1 RCSB PDB | xray | resolution: 1.649 Å | in vitro · -173.15 °C · pH 7 Cryogenic structure of CypA mutant Ser99Thr · Cyclophilin A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3K0Q-1 RCSB PDB | xray | resolution: 2.317 Å | in vitro · -173.15 °C · pH 7.5 Cryogenic structure of CypA mutant Ser99Thr (2) · Cyclophilin A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3K0R-1 RCSB PDB | xray | resolution: 2.424 Å | in vitro · -173.15 °C · pH 7 Cryogenic structure of CypA mutant Arg55Lys · Cyclophilin A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3ODI-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of cyclophilin A in complex with Voclosporin E-ISA247 · Cyclophilin A (chains A,C,E,G,I,K,M,O,Q,S) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3ODL-1 RCSB PDB | xray | resolution: 2.31 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of cyclophilin A in complex with Voclosporin Z-ISA247 · Cyclophilin A (chains A,C,E,G,I,K,M,O,Q,S) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-3RDD-1 RCSB PDB | xray | resolution: 2.14 Å | in vitro · -173.15 °C · pH 7.5 · ligands EA4 Human Cyclophilin A Complexed with an Inhibitor · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4CYH-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · ligands HIS, PRO CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE HIS-PRO · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4IPZ-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · pH 6 · ligands CL SmBz bound to Cyclophilin A · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4N1N-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8 · ligands UNU Structure of Cyclophilin A in complex with Benzamide. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4N1O-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8 · ligands LSA Structure of Cyclophilin A in complex with Saccharin. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4N1Q-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8 · ligands WM2 Structure of Cyclophilin A in complex with cyclohexanecarboxamide. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4N1S-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · pH 8 · ligands WM4 Structure of Cyclophilin A in complex with benzohydrazide. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUG-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C Multiconformer synchrotron model of CypA at 100 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUH-1 RCSB PDB | xray | resolution: 1.34 Å | in vitro · -123.15 °C Multiconformer synchrotron model of CypA at 150 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUJ-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -33.15 °C Multiconformer synchrotron model of CypA at 240 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUK-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -13.15 °C Multiconformer synchrotron model of CypA at 260 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUL-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · 6.85 °C Multiconformer synchrotron model of CypA at 280 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUO-1 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -0.15 °C High-resolution multiconformer synchrotron model of CypA at 273 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUP-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -0.15 °C Multiconformer fixed-target X-ray free electron (XFEL) model of CypA at 273 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5CYH-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · ligands GLY, PRO CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE GLY-PRO · CYCLOPHILIN A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5F66-1 RCSB PDB | xray | resolution: 1.15 Å | in vitro · -0.15 °C · pH 7.5 High-resolution isotropic multiconformer synchrotron model of CypA at 273 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUL-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 1 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUN-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 2 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUO-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 3 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUQ-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 4 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUS-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 6 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUU-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 7 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUV-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 8 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUW-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 9 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUZ-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 1 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV0-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 2 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV1-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 3 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KUR-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 Human cyclophilin A at 100K, Data set 5 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5FJB-2 RCSB PDB | cryoem | resolution: 9 Å | in vitro Cyclophilin A Stabilize HIV-1 Capsid through a Novel Non- canonical Binding Site · PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (chains C) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUN-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · 36.85 °C Multiconformer synchrotron model of CypA at 310 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUM-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · 26.85 °C Multiconformer synchrotron model of CypA at 300 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4YUI-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -93.15 °C Multiconformer synchrotron model of CypA at 180 K · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4N1R-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands WM3 Structure of Cyclophilin A in complex with benzenesulfonohydrazide. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4N1P-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8 · ligands WM1 Structure of Cyclophilin A in complex with Picolinamide. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-4N1M-1 RCSB PDB | xray | resolution: 1.15 Å | in vitro · -173.15 °C · pH 8 · ligands GLY, PRO Structure of Cyclophilin A in complex with GlyPro. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV5-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 7 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5LUD-1 RCSB PDB | xray | resolution: 1.25 Å | in vitro · -173.15 °C · pH 8 · ligands 76X Structure of Cyclophilin A in complex with 2,3-Diaminopyridine · Peptidyl-prolyl cis-trans isomerase (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5TA4-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8.5 · ligands 838, SO4 Discovery of a Potent Cyclophilin Inhibitor (Compound 8) based on Structural Simplification of Sanglifehrin A · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJM-1 RCSB PDB | xray | resolution: 1.354 Å | in vitro · -173.15 °C · pH 8 · ligands L36 Cyclophilin A complexed with tri-vector ligand 4. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6U5D-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · 17.85 °C · pH 7.5 RT XFEL structure of CypA solved using LCP injection system · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6X4N-1 RCSB PDB | xray | resolution: 1.51 Å | in vitro · -173.15 °C · pH 8.5 · ligands UOD Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-3-oxa-9,12,15,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 24) · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6Y9Z-2 RCSB PDB | cryoem | resolution: 4.8 Å | in vitro Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,9) · Peptidyl-prolyl cis-trans isomerase A (chains J) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6Y9Y-2 RCSB PDB | cryoem | resolution: 6.1 Å | in vitro Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-7,13) · Peptidyl-prolyl cis-trans isomerase A (chains J) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6Y9X-2 RCSB PDB | cryoem | resolution: 4.4 Å | in vitro Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,7) · Peptidyl-prolyl cis-trans isomerase A (chains J) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6Y9W-2 RCSB PDB | cryoem | resolution: 4.1 Å | in vitro Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,8) · Peptidyl-prolyl cis-trans isomerase A (chains J) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6Y9V-2 RCSB PDB | cryoem | resolution: 6.9 Å | in vitro Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-8,13) · Peptidyl-prolyl cis-trans isomerase A (chains J) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6X4Q-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands UOJ Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 33) · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6X4P-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands UOG Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 28) · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6X4O-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8.5 · ligands UO7 Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11-dimethyl-14-(propan-2-yl)-3-oxa-9,12,15,21,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(26),18,20,22,24,27-hexaene-4,10,13,16-tetrone (compound 21) · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6X4M-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8.5 · ligands UMM Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: tert-butyl [(2S)-1-{[(3S,17S)-2,16-dioxo-10,15-dioxa-1,21-diazatricyclo[15.3.1.1~5,9~]docosa-5(22),6,8-trien-3-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate (compound 3) · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6X3Y-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 8.5 · ligands UMM Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6X3R-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands ZXX Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6U5G-1 RCSB PDB | microed | resolution: 2.5 Å | in vitro MicroED structure of a FIB-milled CypA Crystal · Peptidyl-prolyl cis-trans isomerase A (chains A) | unmapped |
| EV-PDB-6U5E-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · 17.85 °C · pH 7.5 RT XFEL structure of CypA solved using celloluse carrier media · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6U5C-1 RCSB PDB | xray | resolution: 1.62 Å | in vitro · 17.85 °C · pH 7.5 RT XFEL structure of CypA solved using MESH injection system · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6I42-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · pH 7 Structure of the alpha-Synuclein PreNAC/Cyclophilin A-complex · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GS6-1 RCSB PDB | xray | resolution: 1.16 Å | in vitro · -173.15 °C · ligands DMS, EA4 Cyclophilin A single mutant D66A in complex with an inhibitor. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJY-1 RCSB PDB | xray | resolution: 1.29 Å | in vitro · -173.15 °C · ligands F1Z Cyclophilin A complexed with tri-vector ligand 5. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJR-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · pH 8 · ligands F0W Cyclophilin A complexed with tri-vector ligand 9. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJP-1 RCSB PDB | xray | resolution: 1.94 Å | in vitro · -173.15 °C · pH 8 · ligands F0T Cyclophilin A complexed with tri-vector ligand 7. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJN-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands F0Q, FMT, GOL Cyclophilin A complexed with tri-vector ligand 15. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJL-1 RCSB PDB | xray | resolution: 1.16 Å | in vitro · -173.15 °C · ligands F1Q Cyclophilin A complexed with tri-vector ligand 10. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJJ-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · pH 8 · ligands L36 Cyclophilin A complexed with tri-vector ligand 2. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6GJI-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8 · ligands F1E, GOL Cyclophilin A complexed with the tri-vector ligand 8. · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6BTA-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -0.15 °C · pH 7.5 CypA Mutant - S99T C115S · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5WC7-1 RCSB PDB | xray | resolution: 1.43 Å | in vitro · -0.15 °C · pH 7.5 CypA Mutant - I97V S99T C115S · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5TA2-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · ligands 78X Discovery of a Potent Cyclophilin Inhibitor (Compound 7) based on Structural Simplification of Sanglifehrin A · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5T9Z-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 4.2 · ligands 78R Discovery of a Potent Cyclophilin Inhibitor (Compound 6) based on Structural Simplification of Sanglifehrin A · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5T9W-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands 78E Discovery of a Potent Cyclophilin Inhibitor (Compound 5) based on Structural Simplification of Sanglifehrin A · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5T9U-1 RCSB PDB | xray | resolution: 2.301 Å | in vitro · -173.15 °C · pH 8.5 · ligands 7HG Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A · Peptidyl-prolyl cis-trans isomerase A (chains A,B,C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOZ-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -173.15 °C · pH 8 · ligands L99 Structure of cyclophilin A in complex with 3,4-diaminobenzohydrazide · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOY-1 RCSB PDB | xray | resolution: 1.43 Å | in vitro · -173.15 °C · pH 8 · ligands 93K Structure of cyclophilin A in complex with 3,4-diaminobenzamide · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOX-1 RCSB PDB | xray | resolution: 1.49 Å | in vitro · -173.15 °C · pH 8 · ligands L97 Structure of cyclophilin A in complex with 2-chloropyridin-3-amine · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOW-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · pH 8 · ligands L89 Structure of cyclophilin A in complex with pyridine-3,4-diamine · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOV-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8 · ligands 93B Structure of cyclophilin A in complex with hexahydropyrimidine-2-thione · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOU-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · pH 8 · ligands L60, TRS Structure of cyclophilin A in complex with hexahydropyrimidin-2-one · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOT-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 8 · ligands 938 Structure of cyclophilin A in complex with 4-chloropyrimidin-5-amine · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOS-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 8 · ligands 92Z Structure of cyclophilin A in complex with 3-amino-1H-pyridin-2-one · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOR-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands 93Q Structure of cyclophilin A in complex with 3-methylpyridin-2-amine · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5NOQ-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8 · ligands 93E Structure of cyclophilin A in complex with 3-chloropyridin-2-amine · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV7-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 9 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV6-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 8 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV4-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 6 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV3-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 5 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-5KV2-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 4.85 °C · pH 7.5 Human cyclophilin A at 278K, Data set 4 · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-6ZDJ-2 RCSB PDB | cryoem | resolution: 5.8 Å | in vitro Structure of the native full-length HIV-1 capsid protein in complex with Cyclophilin A from helical assembly (-13,10) · Peptidyl-prolyl cis-trans isomerase A (chains J) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7ABT-1 RCSB PDB | xray | resolution: 1.31 Å | in vitro · -173.15 °C · pH 7.5 Structure of PPIA in complex with PR dipeptide repeat · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7PCJ-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 8.4 X-ray structure of CypA-C52AK125C/CsA/aromatic foldamer complex · Peptidyl-prolyl cis-trans isomerase A (chains A,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7QBW-1 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL Human Cyclophilin A double mutant C52AK125C · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7TA8-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 NMR structure of crosslinked cyclophilin A · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7UXM-1 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · ligands EDO, NH2, WHL Structure of PPIA in complex with FP29092, a Helicon Polypeptide · Peptidyl-prolyl cis-trans isomerase A (chains A,B,C) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7UXN-1 RCSB PDB | xray | resolution: 1.36 Å | in vitro · -173.15 °C · ligands WHL Structure of PPIA in complex with FP29103, a Helicon Polypeptide · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8G9P-2 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 5.5 · ligands CL, GNP, MG, YV2 Tricomplex of RMC-4998, KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8G9Q-2 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands GNP, MG, YV6 Tricomplex of Compound-1, KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8HZ8-1 RCSB PDB | xray | resolution: 1.81 Å | in vitro · 19.85 °C Structure of PPIA in complex with the peptide of NRF2 · Peptidyl-prolyl cis-trans isomerase A, N-terminally processed (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBF-2 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8 · ligands EDO, GNP, MG, ZNI Tricomplex of RMC-7977, KRAS WT, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBG-2 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · pH 8 · ligands GNP, GOL, MG, ZNI Tricomplex of RMC-7977, HRAS WT, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBH-2 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands GNP, MG, ZNI Tricomplex of RMC-7977, KRAS G12R, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBI-2 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C · pH 8 · ligands GNP, MG, ZNI Tricomplex of RMC-7977, NRAS WT, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBJ-2 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 8 · ligands EDO, GNP, GOL, MG, ZNI Tricomplex of RMC-7977, KRAS G12A, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBK-2 RCSB PDB | xray | resolution: 1.26 Å | in vitro · -173.15 °C · pH 7 · ligands GNP, MG, ZNI Tricomplex of RMC-7977, KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBL-2 RCSB PDB | xray | resolution: 1.88 Å | in vitro · -173.15 °C · pH 8 · ligands GNP, MG, ZNI Tricomplex of RMC-7977, KRAS G12D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBM-2 RCSB PDB | xray | resolution: 1.57 Å | in vitro · -173.15 °C · pH 7 · ligands GNP, GOL, MG, ZNI Tricomplex of RMC-7977, KRAS G12V, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-8TBN-2 RCSB PDB | xray | resolution: 1.46 Å | in vitro · -173.15 °C · pH 7 · ligands GNP, MG, ZNI Tricomplex of RMC-7977, KRAS G12S, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9AX6-2 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · ligands A1AHB, GNP, MG Tricomplex of Daraxonrasib (RMC-6236), KRAS G12D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BFV-2 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · ligands A1AOV, GNP, MG Tri-complex of Compound-23, KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BFW-2 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · ligands A1AOM, BTB, GNP, MG Tri-complex of Compound-4, KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BFX-2 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands A1AOD, CL, GNP, MG Tri-complex of Elironrasib (RMC-6291), KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BFY-2 RCSB PDB | xray | resolution: 1.26 Å | in vitro · -173.15 °C · ligands A1AOL, CL, GNP, MG Tri-complex of Compound-14, KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BFZ-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands A1AOK, GNP, MG Tri-complex of Compound-5, KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG0-2 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · pH 8 · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), NRAS WT, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG1-2 RCSB PDB | xray | resolution: 1.51 Å | in vitro · -173.15 °C · ligands A1AOH, GNP, MG Tri-complex of Compound-3, KRAS G12V, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG2-2 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · ligands A1AOJ, GNP, MG Tri-complex of Compound-10, KRAS G12V, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG3-2 RCSB PDB | xray | resolution: 1.33 Å | in vitro · -173.15 °C · pH 8 · ligands A1AHB, CL, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), NRAS Q61K, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG4-2 RCSB PDB | xray | resolution: 1.14 Å | in vitro · -173.15 °C · ligands A1AOG, CL, GNP, MG Tri-complex of Compound-2, KRAS G12V, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG5-2 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · pH 7 · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), KRAS G13D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG6-2 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · pH 7 · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), KRAS G12V, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG7-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · ligands A1AOI, GNP, MG Tri-complex of Compound-6, KRAS G12V, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG8-2 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · pH 5.5 · ligands A1AHB, BTB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), NRAS Q61R, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BG9-2 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 7 · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), KRAS WT, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BGA-2 RCSB PDB | xray | resolution: 1.41 Å | in vitro · -173.15 °C · pH 8 · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), KRAS G12C, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BGB-2 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 8 · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), KRAS Q61H, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BGC-2 RCSB PDB | xray | resolution: 1.87 Å | in vitro · -173.15 °C · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), KRAS G12R, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BGD-2 RCSB PDB | xray | resolution: 1.76 Å | in vitro · -173.15 °C · pH 5.5 · ligands A1AHB, GNP, MG Tri-complex of Daraxonrasib (RMC-6236), NRAS Q61L, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BHO-1 RCSB PDB | xray | resolution: 1.89 Å | in vitro · -173.15 °C · ligands AF3, GDP, MG, ZNI Crystal structure of KRAS G12S in a transition state mimetic complex with CYPA and RMC-7977 · Peptidyl-prolyl cis-trans isomerase A (chains B,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BHP-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands AF3, GDP, MG, ZNI Crystal structure of KRAS G12C in a transition state mimetic complex with CYPA and RMC-7977 · Peptidyl-prolyl cis-trans isomerase A (chains B,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BHQ-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands AF3, GDP, MG, ZNI Crystal structure of KRAS G12A in a transition state mimetic complex with CYPA and RMC-7977 · Peptidyl-prolyl cis-trans isomerase A (chains B,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BI1-2 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · ligands GNP, MG, ZNI Crystal structure of GMPPNP bound KRAS G12D in complex with CYPA and RMC-7977 · Peptidyl-prolyl cis-trans isomerase A (chains B,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9BI2-2 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · ligands GNP, MG, ZNI Crystal structure of GMPPNP bound KRAS G12C in complex with CYPA and RMC-7977 · Peptidyl-prolyl cis-trans isomerase A (chains B,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9CT7-2 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · ligands A1AZV, CL, GNP, MG Tricomplex of Compound 1, KRAS G12D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9CT8-2 RCSB PDB | xray | resolution: 1.28 Å | in vitro · -173.15 °C · ligands A1AZX, CL, GNP, MG Tricomplex of Compound 2, KRAS G12D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9CT9-2 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · ligands A1AZY, CL, GNP, MG Tricomplex of Compound 3, KRAS G12D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7UXJ-1 RCSB PDB | xray | resolution: 2.07 Å | in vitro · -173.15 °C · ligands NH2, WHL Structure of PPIA in complex with FP29102, a Helicon Polypeptide · Peptidyl-prolyl cis-trans isomerase A (chains A,B,C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7UPN-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ZN Maedi visna virus Vif in complex with CypA and E3 ubiquitin ligase · Peptidyl-prolyl cis-trans isomerase A (chains A,B) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-7N9X-5 RCSB PDB | xray | resolution: 3.511 Å | in vitro · -173.15 °C CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions · Peptidyl-prolyl cis-trans isomerase A (chains GGG,HHH,III) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9E3S-2 RCSB PDB | xray | resolution: 1.08 Å | in vitro · -173.15 °C · ligands A1BEA, CL, GNP, GOL, MG Tricomplex of RMC-9945, KRAS G12N, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9YOW-2 RCSB PDB | xray | resolution: 1.57 Å | in vitro · -173.15 °C · ligands A1CYT, GNP, MG Crystal structure of GMPPNP bound KRAS G12C in complex with CYPA and RMC-4791 · Peptidyl-prolyl cis-trans isomerase A (chains B,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9GHY-1 RCSB PDB | xray | resolution: 1.15 Å | in vitro · -173.15 °C · ligands A1ILH, CL Cyclophilin A in complex with Sanglifehrin A analogue (2R,3S,7S,10S,E)-10-(3-aminopropyl)-2,7-dimethylspiro[3,8,11-triaza-1(2,7)-quinolina-5(3,1)-pyridazinacyclopentadecaphanene-13,5'-[1,3]dioxan]-14-ene-4,6,9,12-tetraone · Peptidyl-prolyl cis-trans isomerase A (chains A) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9CTB-1 RCSB PDB | xray | resolution: 1.29 Å | in vitro · -173.15 °C · ligands A1AZZ, CL, GNP, MG Tri-complex of zoldonrasib (RMC-9805), KRAS G12D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-PDB-9CTA-2 RCSB PDB | xray | resolution: 1.29 Å | in vitro · -173.15 °C · ligands A1AZW, GNP, MG Tricomplex of RMC-9945, KRAS G12D, and CypA · Peptidyl-prolyl cis-trans isomerase A (chains C,D) | major (ground) state · rule:cypa-structures-major · low Experimental structure of CypA; the ground state dominates crystal and NMR structures. |
| EV-BMRB-2208 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 6.5 1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25104 BMRB | nmr_shifts | chemical_shift | in vitro · 31.85 °C · pH 6.8 CYCLOPHILIN A COMPLEXED WITH A FRAGMENT OF CRK-II · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25337 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 6.5 Backbone assignments for human Cyclophilin A with saturating concentrations of the model peptide GSFGPDLRAGD · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25502 BMRB | nmr_shifts | chemical_shift | in vitro · 25.85 °C · pH 6.5 Extending the eNOE data set of large proteins by evaluation of NOEs with unresolved diagonals · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-27620 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 7.5 human CYPA/PPIA · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30977 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 NMR structure of crosslinked cyclophilin A · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-531 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.8 1H NMR Studies on Bovine Cyclophilin: Preliminary Structural Characterization of Its Complex with Cyclosporin A · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-532 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.8 1H NMR Studies on Bovine Cyclophilin: Preliminary Structural Characterization of Its Complex with Cyclosporin A · BMRB data: 1H chemical shifts | unmapped |
| EV-AFDB-AF-P62937-F1 AlphaFold DB | af_prediction | plddt: 98.06 pLDDT | in silico AlphaFold DB prediction AF-P62937-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-165 | unmapped |
| EV-MDDB-A00A6 MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 2CPL · start 2CPL; Amber Parm99 | unmapped |
Conflicts
No conflicts found among comparable evidence.
215 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.
Downloads
- Protein bundle (JSON)
- CypA-major-cif (mmCIF, observed)
- CypA-major-pdb (PDB, observed)
- Curation file (YAML)