Talin-1
UniProt P26039 · gene Tln1 · Mus musculus · 2541 residues
81evidence items
0mapped to a state
0states
6techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 81 of 81 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 19 | 0 |
| DisProt | 3 | 0 |
| RCSB PDB | 55 | 0 |
| SMASH-BIO | 3 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-2QDQ-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 4.2 Crystal structure of the talin dimerisation domain · Talin-1 (chains A,B) | unmapped |
| EV-PDB-9DZ5-1 RCSB PDB | xray | resolution: 1.74 Å | in vitro · -173.15 °C Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a D397R mutation · Talin-1 (chains A) | unmapped |
| EV-PDB-9C1T-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · ligands SO4 Crystal structure of integrin beta-3 tail bound to the FERM-folded talin head domain with a D397R mutation · Integrin beta-3, Talin-1 (chains A) | unmapped |
| EV-PDB-9AZ6-2 RCSB PDB | cryoem | resolution: 2.98 Å | in vitro · ligands ADP, MG F-actin-Talin(R13-DD) complex · Talin-1 (chains F,G,H,I,J,K,L,M) | unmapped |
| EV-PDB-8VDR-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro Cryogenic electron microscopy model of full-length talin without R12 and FABD · Green fluorescent protein,Talin-1 (chains A) | unmapped |
| EV-PDB-8VDQ-1 RCSB PDB | cryoem | resolution: 5.5 Å | in vitro Cryogenic electron microscopy model of full-length talin · Green fluorescent protein,Talin-1 (chains A) | unmapped |
| EV-PDB-8VDP-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro Cryogenic electron microscopy model of full-length talin without FABD · Green fluorescent protein,Talin-1 (chains A) | unmapped |
| EV-PDB-8VDO-1 RCSB PDB | cryoem | resolution: 2.7 Å | in vitro Cryogenic electron microscopy model of full-length talin lacking F2, R12 and FABD. · Green fluorescent protein,Talin-1 (chains A) | unmapped |
| EV-PDB-8T0D-1 RCSB PDB | xray | resolution: 2.77 Å | in vitro · -173.15 °C Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with E269A/Y270A/K306Q triple mutation · Integrin beta-2,Talin-1 (chains A) | unmapped |
| EV-PDB-8T0A-1 RCSB PDB | xray | resolution: 2.14 Å | in vitro · -173.15 °C Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a Y270E mutation · Integrin beta-2,Talin-1 (chains A) | unmapped |
| EV-PDB-8IVZ-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C Crystal structure of talin R7 in complex with KANK1 KN motif · Talin-1 (chains A,B) | unmapped |
| EV-PDB-8FTB-1 RCSB PDB | xray | resolution: 1.97 Å | in vitro · -173.15 °C Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a K306Q mutation · Integrin beta-2,Talin-1 (chains B) | unmapped |
| EV-PDB-8FSO-1 RCSB PDB | xray | resolution: 2.33 Å | in vitro · -173.15 °C Crystal structure of integrin beta-6 tail bound to the FERM-folded talin head domain · Integrin beta-6,Talin-1 (chains A) | unmapped |
| EV-PDB-8FSE-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain · Integrin beta-2,Talin-1 (chains A,B) | unmapped |
| EV-PDB-8AS9-3 RCSB PDB | xray | resolution: 3.4 Å | in vitro · -173.15 °C · pH 6.5 · ligands GOL, SO4 Crystal structure of the talin-KANK1 complex · Talin-1 (chains C) | unmapped |
| EV-PDB-7ZW4-1 RCSB PDB | xray | resolution: 2.72 Å | in vitro · -173.15 °C Crystal structure of Talin R7R8 domains with Caskin-2 LD-peptide · Talin-1 (chains A) | unmapped |
| EV-PDB-7V1A-1 RCSB PDB | xray | resolution: 1.845 Å | in vitro · -173.15 °C · ligands EDO Stapled TBS peptide from RIAM bound to talin R7R8 domains · Talin-1 (chains A) | unmapped |
| EV-PDB-6VGU-1 RCSB PDB | xray | resolution: 2.78 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of FERM-folded talin head domain bound to the NPLY motif of beta3-integrin · Integrin beta-3,Talin-1 (chains A) | unmapped |
| EV-PDB-6TWN-1 RCSB PDB | xray | resolution: 2.28 Å | in vitro · -173.15 °C · pH 5.6 · ligands CL, GOL Crystal structure of Talin1 R7R8 in complex with CDK1 (206-223) · Talin-1 (chains A,B) | unmapped |
| EV-PDB-6MFS-1 RCSB PDB | xray | resolution: 2.85 Å | in vitro · -173.15 °C · pH 7 · ligands PIO, PO4 Mouse talin1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2) · Talin-1 fusion (chains A) | unmapped |
| EV-PDB-6BA6-1 RCSB PDB | nmr_structure | structure | in vitro · 27.85 °C · pH 6.6 Solution structure of Rap1b/talin complex · Talin-1 (chains A) | unmapped |
| EV-PDB-5NL1-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 4.6 · ligands CL, EDO, SO4 Shigella IpaA-VBS3/TBS in complex with the Talin VBS1 domain 488-512 · Talin-1 (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-5IC1-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -180.15 °C · ligands EDO Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant · Talin-1 (chains A) | unmapped |
| EV-PDB-5IC0-1 RCSB PDB | xray | resolution: 1.97 Å | in vitro · -180.15 °C · ligands EDO Structural analysis of a talin triple domain module · Talin-1 (chains A) | unmapped |
| EV-PDB-5FZT-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 7.4 · ligands MLI The crystal structure of R7R8 in complex with a DLC1 fragment. · TALIN-1 (chains A) | unmapped |
| EV-PDB-4W8P-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 7.5 · ligands EDO Crystal structure of RIAM TBS1 in complex with talin R7R8 domains · Talin-1 (chains A) | unmapped |
| EV-PDB-4F7G-2 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of talin autoinhibition complex · Talin-1 (chains B) | unmapped |
| EV-PDB-4F7G-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of talin autoinhibition complex · Talin-1 (chains A) | unmapped |
| EV-PDB-3S90-2 RCSB PDB | xray | resolution: 1.97 Å | in vitro · -173.15 °C · pH 5.3 Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues 1512-1546) · Talin-1 (chains C,D) | unmapped |
| EV-PDB-3IVF-1 RCSB PDB | xray | resolution: 1.94 Å | in vitro · -163.15 °C · pH 7.4 Crystal structure of the talin head FERM domain · Talin-1 (chains A) | unmapped |
| EV-PDB-3DYJ-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 7.5 Crystal Structure of the R11R12 Domains of Talin · TALIN-1 (chains A,B) | unmapped |
| EV-PDB-2X0C-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8.5 Crystal Structure of the R7R8 domains of Talin · TALIN-1 (chains A) | unmapped |
| EV-PDB-2LQG-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of the R4 domain of talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2L7N-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of the R5 Domain of Talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2L7A-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of the R3 Domain of Talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2L10-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution Structure of the R6 Domain of Talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2KVP-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.5 Solution Structure of the R10 Domain of Talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2KMA-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain · Talin 1 (chains A) | unmapped |
| EV-PDB-2KGX-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 HADDOCK structure of the talin F3 domain in complex with talin 1655-1822 · MKIAA1027 protein (chains B) | unmapped |
| EV-PDB-2KGX-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 HADDOCK structure of the talin F3 domain in complex with talin 1655-1822 · Talin-1 (chains A) | unmapped |
| EV-PDB-2KC2-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 NMR structure of the F1 domain (residues 86-202) of the talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2KC1-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 NMR structure of the F0 domain (residues 0-85) of the talin ferm domain · MKIAA1027 protein (chains A) | unmapped |
| EV-PDB-2KBB-1 RCSB PDB | nmr_structure | structure | in vitro · 34.85 °C · pH 6.5 Solution Structure of the R9 Domain of Talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2JSW-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 6 Solution Structure of the R13 Domain of Talin · Talin-1 (chains A) | unmapped |
| EV-PDB-2G35-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.3 NMR structure of talin-PTB in complex with PIPKI · Talin-1 (chains A) | unmapped |
| EV-PDB-2B0H-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Solution structure of VBS3 fragment of talin · Talin-1 (chains A) | unmapped |
| EV-PDB-1ZW3-2 RCSB PDB | xray | resolution: 3.3 Å | in vitro · -173.15 °C · pH 6.1 Vinculin Head (0-258) in Complex with the Talin Rod residues 1630-1652 · Talin 1 (chains B) | unmapped |
| EV-PDB-1Y19-2 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 6.2 Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions · Talin 1 (chains B,D,F,H,J,L) | unmapped |
| EV-PDB-1U89-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.5 Solution structure of VBS2 fragment of talin · Talin 1 (chains A) | unmapped |
| EV-PDB-1T01-2 RCSB PDB | xray | resolution: 2.06 Å | in vitro · -173.15 °C · pH 6.5 Vinculin complexed with the VBS1 helix from talin · Talin 1 (chains B) | unmapped |
| EV-PDB-1SJ8-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 5.6 Solution Structure of the R1R2 Domains of Talin · Talin 1 (chains A) | unmapped |
| EV-PDB-1SJ7-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 4.6 · ligands PT Crystal Structure of Talin Rod 482-655 · Talin 1 (chains A,B,C) | unmapped |
| EV-PDB-9QN7-1 RCSB PDB | xray | resolution: 2.76 Å | in vitro · -173.15 °C · pH 7.4 Structure of talin in complex with a peptide fragment · Talin-1 (chains A,B) | unmapped |
| EV-PDB-9SR0-2 RCSB PDB | xray | resolution: 1.49 Å | in vitro · -173.15 °C · pH 6 Mouse vinculin head domain 1 (VD1) (residues 2-258) with A50I mutation in complex with mouse talin 1 helix 50 (H50, residues 2072-2103) · Talin-1 (chains B) | unmapped |
| EV-PDB-9QT7-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of affitin C10 fused to a coiled-coil domain in complex with a quinoline oligoamide foldamer · DNA-binding protein 7d,Talin-1 (chains A,B,C,D) | unmapped |
| EV-BMRB-15411 BMRB | nmr_shifts | chemical_shift | in vitro · 45 °C · pH 6 NMR structure of the talin C-terminal actin binding site · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15457 BMRB | nmr_shifts | chemical_shift | in vitro · 34.85 °C · pH 6.5 NMR Structure of the Talin Rod domain, 1655-1822 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15458 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 NMR Structure of the F0 domain (residues 1-85) of the Talin FERM domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15615 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 NMR Structure of the F0F1 double domain (residues 1-202) of the Talin FERM domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15616 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 NMR Structure of the F1 domain (residues 86-202) of the Talin FERM domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15625 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 NMR Structure of the VBS3 domain (residues 1815-1973) of Talin · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15792 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.8 talin-F2F3 · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-16930 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Chemical shift assignments of the Talin F2 domain (residues 196-309) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-16932 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Chemical shift assignments of the Talin F2F3 domain (residues 196-405) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17070 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 SOLUTION STRUCTURE OF THE R6 DOMAIN OF TALIN · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17332 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Solution Structure of the talin Vbs2b domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17350 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 SOLUTION STRUCTURE OF THE R2 DOMAIN OF TALIN · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17363 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 NMR Structure of the B domain of talin · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17555 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Chemical shift assignments of the VBS1 domain of talin · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18313 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Solution Structure of the A domain of talin · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25343 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 6.8 Talin-F3 / RIAM N-terminal Peptide complex · BMRB data: 1H chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-30353 BMRB | nmr_shifts | chemical_shift | in vitro · 27.85 °C · pH 6.6 Solution structure of Rap1b/talin complex · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-6285 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 6.5 15N, 13C, 1H NMR assignment of a 14kDa construct of the focal adhesion protein Talin · BMRB data: 15N chemical shifts, 1H chemical shifts, 13C chemical shifts | unmapped |
| EV-BMRB-7061 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.3 NMR structure of talin-PTB in complex with PIPKI · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-DISPROT-DP00653r001 DisProt | nmr_shifts | disorder_region: 16 residues | in vitro DisProt DP00653: disorder, residues 799-814 · residues 799-814; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00653r002 DisProt | nmr_shifts | disorder_region: 16 residues | in vitro DisProt DP00653: order to disorder, residues 799-814 · residues 799-814; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00653r003 DisProt | nmr_shifts | disorder_region: 30 residues | in vitro DisProt DP00653: disorder, residues 139-168 · residues 139-168; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-AFDB-AF-P26039-F1 AlphaFold DB | af_prediction | plddt: 76.94 pLDDT | in silico AlphaFold DB prediction AF-P26039-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-2541 | unmapped |
| EV-SMASH-SMFS-001065 SMASH-BIO | force_spectroscopy | study_record | in vitro Biphasic reinforcement of nascent adhesions by vinculin. · Talin-1; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004432 SMASH-BIO | force_spectroscopy | study_record | in vitro Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission. · Talin-1; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-005974 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 What is vinculin needed for in platelets? · Talin-1; optical tweezers; experiment class: force_generation_polymerization, membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
Conflicts
No conflicts found among comparable evidence.
81 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.