Synaptotagmin-1
UniProt P21579 · gene SYT1 · Homo sapiens · 422 residues
35evidence items
0mapped to a state
0states
6techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_structure | nmr_shifts | cd | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 35 of 35 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 1 | 0 |
| DisProt | 1 | 0 |
| RCSB PDB | 24 | 0 |
| SMASH-BIO | 8 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-2K45-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6 C2A domain of synaptototagmin I solution structure in the FGF-1-C2A binary complex: key component in the fibroblast growthfactor non-classical pathway · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-2K4A-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6 FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-2KI6-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6 The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion · Synaptotagmin-1 (chains A,F) | unmapped |
| EV-PDB-2LHA-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6 · ligands IHP Solution structure of C2B with IP6 · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-2N1T-5 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.4 Dynamic binding mode of a synaptotagmin-1-SNARE complex in solution · Synaptotagmin-1 (chains E) | unmapped |
| EV-PDB-3F01-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands CU, SO4 Crystal Structure of Synaptotagmin I C2A domain with Cu(II) · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-3F05-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 7.5 · ligands MN, SO4 Crystal Structure of Synaptotagmin I C2A domain with Mn(II) · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-4V11-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GOL Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84 · SYNAPTOTAGMIN-1 (chains A) | unmapped |
| EV-PDB-6QNS-2 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · ligands branched: N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose Crystal structure of the binding domain of Botulinum Neurotoxin type B mutant I1248W/V1249W in complex with human synaptotagmin 1 and GD1a receptors · Synaptotagmin-1 (chains S) | unmapped |
| EV-PDB-6TZ3-1 RCSB PDB | xray | resolution: 1.17 Å | in vitro · -173.15 °C · pH 6 · ligands SO4 Crystal Structure of Human Synaptotagmin 1 C2B without Ca2+ · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-6U41-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 4.6 · ligands SO4 1.7 angstrom structure of a pathogenic human Syt 1 C2B (D304G) · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-6U4W-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 4 · ligands SO4 1.4 A structure of a pathogenic human Syt 1 C2B (D366E) · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-8B8I-2 RCSB PDB | xray | resolution: 2.75 Å | in vitro · -173.15 °C Nanobody (NbLumSyt1) bound to human Syt1 · Synaptotagmin-1 (chains I,J,K,L,M,N,O,P) | unmapped |
| EV-PDB-7U4Q-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · -173.15 °C · pH 7.1 · ligands CA Human Synaptotagmin-1 C2A Y181F Ca2+ bound · Synaptotagmin-1 (chains A,B) | unmapped |
| EV-PDB-7TUA-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 4.5 · ligands SO4 Human Synaptotagmin-1 C2B Y312F without Ca2+ · Synaptotagmin (chains A) | unmapped |
| EV-PDB-6ZVN-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 8 Botulinum neurotoxin B2 binding domain in complex with human synaptotagmin I · Synaptotagmin-1 (chains BBB) | unmapped |
| EV-PDB-6U4U-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · ligands SO4 1.3 A structure of a pathogenic human Syt 1 C2B (I368T) · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-6G5K-2 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the binding domain of Botulinum Neurotoxin type B in complex with human synaptotagmin 1 · Synaptotagmin-1 (chains 33,C) | unmapped |
| EV-PDB-6G5F-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7 · ligands GOL, MLI Crystal structure of an engineered Botulinum Neurotoxin type B mutant E1191M/S1199Y in complex with human synaptotagmin 1 · Synaptotagmin-1 (chains P) | unmapped |
| EV-PDB-4ISQ-2 RCSB PDB | xray | resolution: 2.65 Å | in vitro · -173.15 °C · pH 7 · ligands GOL, SO4 Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I · Synaptotagmin-1 (chains D,E,F) | unmapped |
| EV-PDB-3F04-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 7.5 · ligands SO4 Crystal Structure of Synaptotagmin I C2A domain · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-3F00-1 RCSB PDB | xray | resolution: 1.36 Å | in vitro · -173.15 °C · pH 7.5 · ligands CU, SO4 Crystal Structure of Synaptotagmin I C2A domain with Cu(II) · Synaptotagmin-1 (chains A) | unmapped |
| EV-PDB-2R83-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 4.5 · ligands CL Crystal structure analysis of human synaptotagmin 1 C2A-C2B · Synaptotagmin-1 (chains A,B) | unmapped |
| EV-PDB-2K8M-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 5.7 S100A13-C2A binary complex structure · Putative uncharacterized protein (chains A,D) | unmapped |
| EV-BMRB-15785 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6 C2A domain of synaptototagmin I solution structure in the FGF-1-C2A binary complex: key component in the fibroblast growthfactor non-classical pathway · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-DISPROT-DP04145r004 DisProt | cd | disorder_region: 62 residues | in vitro DisProt DP04145: disorder, residues 81-142 · residues 81-142; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-AFDB-AF-P21579-F1 AlphaFold DB | af_prediction | plddt: 81.81 pLDDT | in silico AlphaFold DB prediction AF-P21579-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-422 | unmapped |
| EV-SMASH-SMFS-001526 SMASH-BIO | force_spectroscopy | study_record | in vitro Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin-1 -PI(4,5)P2 Interaction in Constrained Geometries. · Synaptotagmin-1; force spectroscopy unspecified; experiment class: membrane_mechanics, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001686 SMASH-BIO | force_spectroscopy | study_record | in vitro Quantitative Models of Lipid Transfer and Membrane Contact Formation · Synaptotagmin-1; optical tweezers; experiment class: membrane_mechanics | unmapped |
| EV-SMASH-SMFS-001721 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-Molecule Optical Tweezers Study of Protein-Membrane Interactions. · Synaptotagmin-1; optical tweezers; experiment class: membrane_mechanics, nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002133 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-Molecule Manipulation of Macromolecules on Membranes Using High-Resolution Optical Tweezers · Synaptotagmin-1; optical tweezers; experiment class: membrane_mechanics, unfolding_nucleic_acid, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002146 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule manipulation of macromolecules on GUV or SUV membranes using optical tweezers. · Synaptotagmin-1; optical tweezers; experiment class: membrane_mechanics, unfolding_nucleic_acid, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003715 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule force spectroscopy of protein-membrane interactions · Synaptotagmin-1; optical tweezers; experiment class: membrane_mechanics, nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003716 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Single-molecule force spectroscopy of protein-membrane interactions. · Synaptotagmin-1; optical tweezers; experiment class: membrane_mechanics, nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005821 SMASH-BIO | force_spectroscopy | study_record | in vitro Interaction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy. · Synaptotagmin-1; afm smfs; experiment class: membrane_mechanics, rheology_cell | unmapped |
Conflicts
No conflicts found among comparable evidence.
35 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.