Filamin-A
UniProt P21333 · gene FLNA · Homo sapiens · 2647 residues
62evidence items
0mapped to a state
0states
7techniques
6sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | saxs_sans | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|---|
| No states defined yet. | |||||||||
Unmapped evidence: 62 of 62 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 2 | 0 |
| DisProt | 1 | 0 |
| RCSB PDB | 26 | 0 |
| SASBDB | 13 | 0 |
| SMASH-BIO | 19 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-2AAV-1 RCSB PDB | nmr_structure | structure | in vitro · 19.85 °C · pH 6.7 Solution NMR structure of Filamin A domain 17 · Filamin A (chains A) | unmapped |
| EV-PDB-2BP3-1 RCSB PDB | xray | resolution: 2.32 Å | in vitro · -173.15 °C · pH 8.2 · ligands GOL Crystal structure of Filamin A domain 17 and GPIb alpha cytoplasmic domain complex · FILAMIN A (chains A,B) | unmapped |
| EV-PDB-2BRQ-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 5.5 · ligands GOL, GSH Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide · FILAMIN A (chains A,B) | unmapped |
| EV-PDB-2J3S-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 6.1 · ligands BR, DIO, GOL Crystal structure of the human filamin A Ig domains 19 to 21 · FILAMIN-A (chains A,B) | unmapped |
| EV-PDB-2JF1-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 4.6 · ligands GOL CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE · FILAMIN-A (chains A) | unmapped |
| EV-PDB-2K3T-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.8 Solution Structure of IG-Like Domain 23 from Human Filamin A · Filamin-A (chains A) | unmapped |
| EV-PDB-2K7P-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.8 Filamin A Ig-like domains 16-17 · Filamin-A (chains A) | unmapped |
| EV-PDB-2MTP-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.4 The structure of Filamin repeat 21 bound to integrin · Filamin-A (chains A) | unmapped |
| EV-PDB-2W0P-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands SO4 Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide · FILAMIN-A (chains A,B) | unmapped |
| EV-PDB-3CNK-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8.2 · ligands SO4 Crystal Structure of the dimerization domain of human filamin A · Filamin-A (chains A,B) | unmapped |
| EV-PDB-3HOC-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -153.15 °C · pH 8.8 · ligands PO4 Structure of the actin-binding domain of human filamin A mutant E254K · Filamin-A (chains A,B) | unmapped |
| EV-PDB-3HOP-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -153.15 °C · pH 8.5 · ligands PO4 Structure of the actin-binding domain of human filamin A · Filamin-A (chains A,B) | unmapped |
| EV-PDB-3HOR-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -153.15 °C · pH 8.5 · ligands PO4 Structure of the actin-binding domain of human filamin A (reduced) · Filamin-A (chains A,B) | unmapped |
| EV-PDB-3RGH-1 RCSB PDB | xray | resolution: 2.44 Å | in vitro · -180.15 °C · pH 5.5 · ligands ACT Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens · Filamin-A (chains A,B) | unmapped |
| EV-PDB-4M9P-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · pH 4 Crystal structure of the human filamin A Ig-like domains 3-5 · Filamin-A (chains A) | unmapped |
| EV-PDB-4P3W-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8 · ligands NA, PR, SO4 Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide · Filamin-A (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-5XR1-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.2 Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2 · C-terminal peptide of Integrin beta-2,Filamin-A IG21 domain (chains A) | unmapped |
| EV-PDB-6D8C-1 RCSB PDB | cryoem | resolution: 3.54 Å | in vitro · ligands ADP, MG Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin · Filamin-A (chains A,B,C,D,E) | unmapped |
| EV-PDB-6EW1-1 RCSB PDB | xray | resolution: 2.30701 Å | in vitro · -173.15 °C Crystal structure of the Filamin A Ig-like domains 3-5 mutant P637Q · Filamin-A (chains A) | unmapped |
| EV-PDB-7SFT-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.4 Filamin complex-2 · Filamin-A (chains A) | unmapped |
| EV-PDB-9LWX-1 RCSB PDB | xray | resolution: 2.29 Å | in vitro · -193.15 °C Crystal structure of the Filamin A repeat 21 · Filamin-A (chains A,B,C,D) | unmapped |
| EV-PDB-9LXG-1 RCSB PDB | xray | resolution: 2.46 Å | in vitro · -193.15 °C Filamin A repeat 21 in complex with LARP4 Ala269-Asn281 peptide · Filamin-A (chains A) | unmapped |
| EV-PDB-7SC4-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · ligands SO4 filamin complex-1 · Filamin-A/Integrin alpha-IIb light chain, form 2 chimera (chains A,B) | unmapped |
| EV-PDB-3ISW-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 7 Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR · Filamin-A (chains A,B) | unmapped |
| EV-PDB-2WFN-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · ligands SO4 Filamin A actin binding domain · FILAMIN-A (chains A,B) | unmapped |
| EV-PDB-2K7Q-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.8 Filamin A Ig-like domains 18-19 · Filamin-A (chains A) | unmapped |
| EV-BMRB-27795 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7 FLNa4-6 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30958 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.4 Filamin complex-2 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-SASBDB-SASDAE8 SASBDB | saxs_sans | radius_of_gyration: 2.41 nm | in vitro · pH 8 Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21. · Human Filamin A Ig-like domains 20-21/migfilin peptide complex | unmapped |
| EV-SASBDB-SASDAF8 SASBDB | saxs_sans | radius_of_gyration: 2.43 nm | in vitro · pH 8 Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21. · Human Filamin A Ig-like domains 20-21 | unmapped |
| EV-SASBDB-SASDAG8 SASBDB | saxs_sans | radius_of_gyration: 2.35 nm | in vitro · pH 8 Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21. · Human Filamin A Ig-like domains 20-21*/migfilin peptide complex | unmapped |
| EV-SASBDB-SASDAH8 SASBDB | saxs_sans | radius_of_gyration: 1.9 nm | in vitro · pH 8 Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21. · Human Filamin A Ig-like domains 20-21* | unmapped |
| EV-SASBDB-SASDB32 SASBDB | saxs_sans | radius_of_gyration: 1.83 nm | in vitro · 20 °C Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing. · Human Filamin A Ig-like domains 16-17 | unmapped |
| EV-SASBDB-SASDB42 SASBDB | saxs_sans | radius_of_gyration: 2.4 nm | in vitro · 20 °C Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing. · Human Filamin A Ig-like domains 16-17* | unmapped |
| EV-SASBDB-SASDEP7 SASBDB | saxs_sans | radius_of_gyration: 2.21 nm ± 0.1 | in vitro · 20 °C · pH 8 Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A. · Filamin A Ig.like domains 3-5 P637Q mutant | unmapped |
| EV-SASBDB-SASDEQ7 SASBDB | saxs_sans | radius_of_gyration: 2.19 nm ± 0.1 | in vitro · 20 °C · pH 8 Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A. · Filamin A Ig-like domains 3-5 | unmapped |
| EV-SASBDB-SASDFD3 SASBDB | saxs_sans | radius_of_gyration: 2.73 nm ± 0.03 | in vitro · 20 °C · pH 8 Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia. · Filamin A Ig-like domains 4-6 | unmapped |
| EV-SASBDB-SASDFE3 SASBDB | saxs_sans | radius_of_gyration: 4.07 nm ± 0.2 | in vitro · 20 °C · pH 8 Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia. · Filamin A Ig-like domains 4-6, V711D mutation | unmapped |
| EV-SASBDB-SASDFF3 SASBDB | saxs_sans | radius_of_gyration: 3.95 nm ± 0.14 | in vitro · 20 °C · pH 8 Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia. · Filamin A Ig-like domains 4-6, V711D mutation | unmapped |
| EV-SASBDB-SASDFG3 SASBDB | saxs_sans | radius_of_gyration: 4.29 nm ± 0.1 | in vitro · 20 °C · pH 8 Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia. · Filamin A Ig-like domains 4-6, H743P mutation | unmapped |
| EV-SASBDB-SASDFH3 SASBDB | saxs_sans | radius_of_gyration: 3.99 nm ± 0.1 | in vitro · 20 °C · pH 8 Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia. · Filamin A Ig-like domains 4-6, H743P mutation | unmapped |
| EV-DISPROT-DP01950r001 DisProt | xray | disorder_region: 36 residues | in vitro DisProt DP01950: disorder, residues 1-36 · residues 1-36; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-AFDB-AF-P21333-F1 AlphaFold DB | af_prediction | plddt: 76.56 pLDDT | in silico AlphaFold DB prediction AF-P21333-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-2647 | unmapped |
| EV-SMASH-SMFS-001163 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-Dependent Structural Changes of Filamin C Rod Domains Regulated by Filamin C Dimer. · Filamin A; magnetic tweezers; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002155 SMASH-BIO | force_spectroscopy | study_record | in vitro SlyD Accelerates trans-to-cis Prolyl Isomerization in a Mechanosignaling Protein under Load. · Filamin A; afm smfs; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002240 SMASH-BIO | force_spectroscopy | study_record | in vitro An Exactly Solvable Stochastic Kinetic Theory of Single-Molecule Force Experiments. · Filamin A; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002506 SMASH-BIO | force_spectroscopy | study_record | in vitro Rate-dependent force-extension models for single-molecule force spectroscopy experiments. · Filamin A; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003913 SMASH-BIO | force_spectroscopy | study_record | in vitro Glycoprotein Ib-IX-V Complex Transmits Cytoskeletal Forces That Enhance Platelet Adhesion. · Filamin A; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003938 SMASH-BIO | force_spectroscopy | study_record | in vitro Kinetic Ductility and Force-Spike Resistance of Proteins from Single-Molecule Force Spectroscopy. · Filamin A; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004849 SMASH-BIO | force_spectroscopy | study_record | in vitro Domain-domain interactions in filamin A (16-23) impose a hierarchy of unfolding forces. · Filamin A; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004925 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function. · Filamin A; magnetic tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005475 SMASH-BIO | force_spectroscopy | study_record | in vitro Differential mechanical stability of filamin A rod segments. · Filamin A; magnetic tweezers; experiment class: force_generation_polymerization, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005529 SMASH-BIO | force_spectroscopy | study_record | in vitro Improved high-force magnetic tweezers for stretching and refolding of proteins and short DNA. · Filamin A; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005748 SMASH-BIO | force_spectroscopy | study_record | in vitro Complex unfolding kinetics of single-domain proteins in the presence of force. · Filamin A; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-006158 SMASH-BIO | force_spectroscopy | study_record | in vitro Protein mechanical unfolding: Importance of non-native interactions. · Filamin A; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-006376-r1 SMASH-BIO | force_spectroscopy | loading_rate: 50 pN/s | in vitro Measuring molecular rupture forces between single actin filaments and actin-binding proteins. · Filamin A; force spectroscopy unspecified; experiment class: force_generation_polymerization, receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-006402 SMASH-BIO | force_spectroscopy | study_record | in vitro New method for deciphering free energy landscape of three-state proteins. · Filamin A; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-006555 SMASH-BIO | force_spectroscopy | study_record | in vitro Direct observation of active protein folding using lock-in force spectroscopy. · Filamin A; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007075 SMASH-BIO | force_spectroscopy | study_record | in vitro Temperature softening of a protein in single-molecule experiments. · Filamin A; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007078 SMASH-BIO | force_spectroscopy | study_record | in vitro The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments. · Filamin A; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007098 SMASH-BIO | force_spectroscopy | study_record | in vitro A mechanical unfolding intermediate in an actin-crosslinking protein. · Filamin A; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007438 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanical unfolding of single filamin A (ABP-280) molecules detected by atomic force microscopy. · Filamin A; afm smfs; experiment class: translation_transcription_replication, unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
55 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.