Myosin-7
UniProt P12883 · gene MYH7 · Homo sapiens · 1935 residues
88evidence items
0mapped to a state
0states
5techniques
4sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|
| No states defined yet. | |||||||
Unmapped evidence: 88 of 88 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 1 | 0 |
| RCSB PDB | 47 | 0 |
| SMASH-BIO | 39 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-2FXM-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 8.5 · ligands HG Structure of the human beta-myosin S2 fragment · Myosin heavy chain, cardiac muscle beta isoform (chains A,B) | unmapped |
| EV-PDB-2FXO-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7.5 Structure of the human beta-myosin S2 fragment · Myosin heavy chain, cardiac muscle beta isoform (chains A,B,C,D) | unmapped |
| EV-PDB-3DTP-1 RCSB PDB | cryoem | resolution: 20 Å | in vitro Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick filament Cryo-EM 3D-MAP · Myosin-11,Myosin-7 (chains A) | unmapped |
| EV-PDB-3DTP-2 RCSB PDB | cryoem | resolution: 20 Å | in vitro Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick filament Cryo-EM 3D-MAP · Myosin-11,Myosin-7 (chains B) | unmapped |
| EV-PDB-4DB1-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 5.5 · ligands ANP, MN Cardiac human myosin S1dC, beta isoform complexed with Mn-AMPPNP · Myosin-7 (chains A,B) | unmapped |
| EV-PDB-4P7H-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · pH 6 · ligands SO4 Structure of Human beta-Cardiac Myosin Motor Domain::GFP chimera · Myosin-7,Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-4PA0-1 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · pH 6 · ligands 2OW, GOL Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain · Myosin-7,Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-4XA1-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · pH 7.6 Crystal Structure of the coiled-coil surrounding Skip 1 of MYH7 · Gp7-MYH7(1173-1238)-EB1 chimera protein (chains A,B,C,D) | unmapped |
| EV-PDB-4XA3-1 RCSB PDB | xray | resolution: 2.548 Å | in vitro · -173.15 °C · pH 5 Crystal structure of the coiled-coil surrounding Skip 2 of MYH7 · Gp7-MYH7(1361-1425)-Eb1 chimera protein (chains A,B) | unmapped |
| EV-PDB-4XA4-1 RCSB PDB | xray | resolution: 2.327 Å | in vitro · -173.15 °C · pH 8.5 Crystal Structure of the coiled-coil surrounding Skip 3 of MYH7 · Xrcc4-MYH7(1551-1609) chimera protein (chains A,B) | unmapped |
| EV-PDB-4XA6-1 RCSB PDB | xray | resolution: 3.42 Å | in vitro · -173.15 °C · pH 6.4 Crystal Structure of the coiled-coil surrounding Skip 4 of MYH7 · Gp7-MYH7(1777-1855)-EB1 chimera protein (chains A,B,C,D) | unmapped |
| EV-PDB-5CHX-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 7 Crystal Structure of amino acids 1590-1657 of MYH7 · Xrcc4-MYH7-1590-1657 (chains A,B) | unmapped |
| EV-PDB-5CJ0-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 7 Crystal Structure of Amino Acids 1631-1692 of MYH7 · Xrcc4-MYH7-(1631-1692) chimera protein (chains A,B) | unmapped |
| EV-PDB-5CJ1-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to Gp7 · Gp7-MYH7-(1526-1571) chimera protein (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-5CJ4-1 RCSB PDB | xray | resolution: 3.102 Å | in vitro · -173.15 °C · pH 8 Crystal Structure of Amino Acids 1562-1622 of MYH7 · Xrcc4-MYH7-(1562-1622) chimera protein (chains A,B,C,D) | unmapped |
| EV-PDB-5TBY-1 RCSB PDB | cryoem | resolution: 20 Å | in vitro HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240) · Myosin-7 (chains A,B) | unmapped |
| EV-PDB-5WJ7-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7.5 Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Xrcc4 · DNA repair protein XRCC4,Myosin-7 (chains A,B) | unmapped |
| EV-PDB-5WJB-1 RCSB PDB | xray | resolution: 2.905 Å | in vitro · -173.15 °C · pH 7.5 Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Gp7 · Capsid assembly scaffolding protein,Myosin-7 (chains A,B,C,D) | unmapped |
| EV-PDB-5WLQ-1 RCSB PDB | xray | resolution: 3.104 Å | in vitro · -173.15 °C · pH 9 · ligands SO4, TMO Crystal Structure of Amino Acids 1677-1755 of Human Beta Cardiac Myosin Fused to Gp7 and Eb1 · Capsid assembly scaffolding protein,Myosin-7,Microtubule-associated protein RP/EB family member 1 (chains A) | unmapped |
| EV-PDB-5WLZ-1 RCSB PDB | xray | resolution: 3.5 Å | in vitro · -173.15 °C · pH 7 Crystal Structure of Amino Acids 1677-1758 of Human Beta Cardiac Myosin Fused to Xrcc4 · DNA repair protein XRCC4,Myosin-7 (chains A,B,C,D) | unmapped |
| EV-PDB-5WME-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 5 Crystal Structure of Amino Acids 1729-1786 of Human Beta Cardiac Myosin Fused to Gp7 as Anti-Parallel Four-Helix Bundle · Capsid assembly scaffolding protein,Myosin-7 (chains A,B,C,D) | unmapped |
| EV-PDB-6PF2-1 RCSB PDB | xray | resolution: 2.17 Å | in vitro · -173.15 °C · pH 8 · ligands EDO Crystal Structure of Amino Acids 1220-1276 of Human Beta Cardiac Myosin Fused to Gp7 and Eb1 · Myosin, heavy polypeptide 7, cardiac muscle, beta variant (chains A,B) | unmapped |
| EV-PDB-6PFP-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands MPD, SO4 Crystal Structure of Amino Acids 1473-1536 of Human Beta Cardiac Myosin Fused to Gp7 and Eb1 · Myosin-7 fused to GP7 and EB1 (chains A,B,C,D) | unmapped |
| EV-PDB-8ACT-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands ADP, MG, PO4 structure of the human beta-cardiac myosin folded-back off state · Myosin-7 (chains A,B) | unmapped |
| EV-PDB-8EFE-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands ADP, MG Human beta-cardiac myosin II bound to ADP-MG2+ and the associated essential light chain · Beta-cardiac myosin II (chains A) | unmapped |
| EV-PDB-8EFH-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ADP, MG Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in complex with ADP-Mg2+ · beta-cardiac myosin II (chains A) | unmapped |
| EV-PDB-8EFI-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, MG Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in the rigor form · Myosin-7 (chains M) | unmapped |
| EV-PDB-8ENC-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands ADP, MG Helical reconstruction of the human cardiac actin-tropomyosin-myosin loop 4 7G mutant complex · Myosin-7 (chains M) | unmapped |
| EV-PDB-8G4L-1 RCSB PDB | cryoem | resolution: 6.4 Å | in vitro Cryo-EM structure of the human cardiac myosin filament · Myosin-7 (chains A,AA,AB,AG,AH,AI,AJ,AK,AL,AM,AN,AO,AP,AQ,AR,AS,AT,AU,AV,AW,AX,AY,AZ,B,BA,BB,BG,BH,BI,BJ,BK,BL,BM,BN,BO,BP,BQ,BR,BS,BT,BU,BV,BW,BX,BY,BZ,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,ae,af,ak,al,be,bf,bk,bl,e,f,k,l) | unmapped |
| EV-PDB-8ZB7-1 RCSB PDB | cryoem | resolution: 3.19 Å | in vitro · ligands ADP Human left ventricle ATM complex · Myosin-7 (chains G,H,I,J,K,M) | unmapped |
| EV-PDB-8ZI9-1 RCSB PDB | cryoem | resolution: 3.08 Å | in vitro · ligands ADP Human left ventricle actin and myosin complex · Myosin-7 (chains M) | unmapped |
| EV-PDB-9GZ1-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro · ligands ADP, MG, PO4, XB2 Beta-cardiac myosin interacting heads motif complexed to mavacamten · Myosin-7 (chains A,B) | unmapped |
| EV-PDB-9GZ2-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands ADP, MG, PO4, XB2 Beta-cardiac heavy meromyosin motor domain in the primed state complexed to mavacamten · Myosin-7 (chains A) | unmapped |
| EV-PDB-9GZ3-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands ADP, MG, PO4 Beta-cardiac heavy meromyosin motor domain in the primed state · Myosin-7 (chains A) | unmapped |
| EV-PDB-9HTF-1 RCSB PDB | xray | resolution: 2.481 Å | in vitro · -173.15 °C · pH 8 · ligands ADP, EDO, GOL, MG, VO4 Beta-cardiac myosin Y115H mutant motor domain in the pre-powerstroke state, MgADP.VO4 form · Myosin-7 (chains A) | unmapped |
| EV-PDB-9HTG-1 RCSB PDB | xray | resolution: 2.596 Å | in vitro · -173.15 °C · pH 8 · ligands ADP, EDO, GOL, MG, VO4 Beta-cardiac myosin E497D mutant motor domain in the pre-powerstroke state, MgADP.VO4 form · Myosin-7 (chains A) | unmapped |
| EV-PDB-9I8P-1 RCSB PDB | xray | resolution: 2.601 Å | in vitro · -173.15 °C · pH 8 · ligands ADP, EDO, GOL, MG, SO4, VO4 Human beta-cardiac myosin wild type motor domain in the pre-powerstroke state, MgADP.VO4 form · Myosin-7 (chains A) | unmapped |
| EV-PDB-9TPJ-1 RCSB PDB | cryoem | resolution: 3.02 Å | in vitro · ligands ADP, MG, PO4 Human Cardiac Interacting Heads Motif, E525K mutant · Myosin-7 (chains A,B) | unmapped |
| EV-PDB-9TPK-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands ADP, MG, PO4 Human Cardiac Interacting Heads Motif, Conformation B · Myosin-7 (chains A,B) | unmapped |
| EV-PDB-9TPL-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands ADP, MG, PO4 Human Cardiac Interacting Heads Motif, Conformation A · Myosin-7 (chains A,B) | unmapped |
| EV-PDB-9YOP-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ADP, PO4 Cryo-EM structure of human beta-cardiac myosin in the interacting-heads motif and S2-FH docked state · Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-9YP4-1 RCSB PDB | cryoem | resolution: 4.5 Å | in vitro · ligands 2OW, ADP, PO4 Cryo-EM structure of human beta-cardiac myosin bound to omecamtiv mecarbil in the interacting-heads motif and S2-FH docked state · Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-9YP9-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands ADP, PO4, XB2 Cryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH docked state · Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-9YR7-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands ADP, PO4, XB2 Cryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH undocked state · Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-9YRG-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands ADP, PO4 Cryo-EM structure of human beta-cardiac myosin in the interacting-heads motif and S2-FH undocked state · Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-9YRH-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands 2OW, ADP, PO4 Cryo-EM structure of human beta-cardiac myosin bound to omecamtiv mecarbil in the interacting-heads motif and S2-FH undocked state · Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein (chains A,B) | unmapped |
| EV-PDB-8EFD-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro Human cardiac myosin II and associated essential light chain in the rigor conformation · Beta-cardiac myosin II (chains A) | unmapped |
| EV-BMRB-19518 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.2 Solution NMR assignment of the heavy chain complex of the human cardiac myosin regulatory light chain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-P12883-F1 AlphaFold DB | af_prediction | plddt: 74.25 pLDDT | in silico AlphaFold DB prediction AF-P12883-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-1935 | unmapped |
| EV-SMASH-SMFS-000201 SMASH-BIO | force_spectroscopy | study_record | in vitro Motor Occupancy Defines Emergent Mechanical States in Cardiac Myosin Ensembles · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-000210 SMASH-BIO | force_spectroscopy | study_record | in vitro Myotropes unveil two myosin cycles with distinct kinetics and stroke size · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-000288 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule analysis sheds light on cardiac myosin dysfunction due to hypertrophic cardiomyopathy mutation A57D in ventricular myosin light chain-1 (MLC1v) · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-000327 SMASH-BIO | force_spectroscopy | study_record | in vitro The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motor · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-000594 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: Application to the study of human β-cardiac myosin. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000595 SMASH-BIO | force_spectroscopy | study_record | in vitro S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: application to the study of human β-cardiac myosin · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000640 SMASH-BIO | force_spectroscopy | study_record | in vitro The Z-disc protein α-actinin-2 forms a force-activated, directional bond with F-actin · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-000792 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001179 SMASH-BIO | force_spectroscopy | study_record | in vitro Homologous mutations in β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001310 SMASH-BIO | force_spectroscopy | study_record | in vitro Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments · β-cardiac myosin (MYH7); force spectroscopy unspecified; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001323 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule mechanics and kinetics of cardiac myosin interacting with regulated thin filaments. · β-cardiac myosin (MYH7); force spectroscopy unspecified; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001541 SMASH-BIO | force_spectroscopy | study_record | in vitro High-Speed Optical Traps Address Dynamics of Processive and Non-Processive Molecular Motors. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001805 SMASH-BIO | force_spectroscopy | study_record | in vitro A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001957 SMASH-BIO | force_spectroscopy | study_record | in vitro Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002033 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002039 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy. · β-cardiac myosin (MYH7); afm smfs; experiment class: force_generation_motor, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002381 SMASH-BIO | force_spectroscopy | study_record | in vitro Human hypertrophic cardiomyopathy mutation R712L suppresses the working stroke of cardiac myosin and can be rescued by omecamtiv mecarbil · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002383 SMASH-BIO | force_spectroscopy | study_record | in vitro Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-002456 SMASH-BIO | force_spectroscopy | study_record | in vitro Myosin from the ventricle is more sensitive to omecamtiv mecarbil than myosin from the atrium. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002459 SMASH-BIO | force_spectroscopy | study_record | in vitro Nanomechanical phenotypes in cMyBP-C mutants that cause hypertrophic cardiomyopathy · β-cardiac myosin (MYH7); afm smfs; experiment class: force_generation_motor, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002892 SMASH-BIO | force_spectroscopy | study_record | in vitro Single molecule mechanics resolves the earliest events in force generation by cardiac myosin · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-002893 SMASH-BIO | force_spectroscopy | study_record | in vitro Single molecule mechanics resolves the earliest events in force generation by cardiac myosin. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-003020 SMASH-BIO | force_spectroscopy | study_record | in vitro Carbonylation of atrial myosin prolongs its interaction with actin. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-003539 SMASH-BIO | force_spectroscopy | study_record | in vitro How to Measure Load-Dependent Kinetics of Individual Motor Molecules Without a Force-Clamp. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004000 SMASH-BIO | force_spectroscopy | study_record | in vitro Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function. · β-cardiac myosin (MYH7); force spectroscopy unspecified; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004232 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004574 SMASH-BIO | force_spectroscopy | study_record | in vitro Inherent force-dependent properties of β-cardiac myosin contribute to the force-velocity relationship of cardiac muscle. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004733 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-004827 SMASH-BIO | force_spectroscopy | study_record | in vitro Cross-species mechanical fingerprinting of cardiac myosin binding protein-C. · β-cardiac myosin (MYH7); force spectroscopy unspecified; experiment class: force_generation_motor, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004948 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-005006 SMASH-BIO | force_spectroscopy | study_record | in vitro Regulatory light chain mutants linked to heart disease modify the cardiac myosin lever arm. · β-cardiac myosin (MYH7); force spectroscopy unspecified; experiment class: force_generation_motor, rheology_cell | unmapped |
| EV-SMASH-SMFS-005563 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy. · β-cardiac myosin (MYH7); afm smfs; experiment class: force_generation_motor, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005812 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006169 SMASH-BIO | force_spectroscopy | study_record | in vitro Removal of the cardiac myosin regulatory light chain increases isometric force production. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006756 SMASH-BIO | force_spectroscopy | study_record | in vitro Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006821 SMASH-BIO | force_spectroscopy | study_record | in vitro Functional studies of individual myosin molecules. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, rheology_cell | unmapped |
| EV-SMASH-SMFS-007285 SMASH-BIO | force_spectroscopy | study_record | in vitro Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007486 SMASH-BIO | force_spectroscopy | study_record | in vitro Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-007510 SMASH-BIO | force_spectroscopy | study_record | in vitro R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level. · β-cardiac myosin (MYH7); optical tweezers; experiment class: force_generation_motor, rheology_cell | unmapped |
Conflicts
No conflicts found among comparable evidence.
88 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.