Amyloid-beta precursor protein
UniProt P12023 · gene App · Mus musculus · 770 residues
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 16 of 16 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 8 | 0 |
| RCSB PDB | 6 | 0 |
| SMASH-BIO | 1 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-4YN0-2 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 8.6 · ligands MG, NAG Crystal structure of APP E2 domain in complex with DR6 CRD domain · Amyloid beta A4 protein (chains B) | unmapped |
| EV-PDB-5MYK-3 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb · Amyloid beta A4 protein (chains C) | unmapped |
| EV-PDB-7MRN-2 RCSB PDB | xray | resolution: 3.5 Å | in vitro · -173.15 °C Mouse CNTN5 APP complex · N-APP (chains C,D) | unmapped |
| EV-PDB-8S4Y-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 8.5 Crystal structure of an APP-talin (F2F3) chimera · C31 (chains A) | unmapped |
| EV-PDB-8BG9-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta · Amyloid-beta protein 40 (chains A,B) | unmapped |
| EV-PDB-2ROZ-1 RCSB PDB | nmr_structure | structure | in vitro · 22.85 °C · pH 7 Structure of the C-terminal PID Domain of Fe65L1 Complexed with the Cytoplasmic Tail of APP Reveals a Novel Peptide Binding Mode · peptide from Amyloid beta A4 protein (chains A) | unmapped |
| EV-BMRB-10236 BMRB | nmr_shifts | chemical_shift | in vitro · 22.85 °C · pH 7 Structure of the C-terminal PID Domain of Fe65L1 Complexed with the Cytoplasmic Tail of APP Reveals a Novel Peptide Binding Mode · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15775 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 6.5 Backbone chemical shift assignment for the transmembrane and C-terminal domains of amyloid precursor protein (APP C99) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17884 BMRB | nmr_shifts | chemical_shift | in vitro · 4.85 °C · pH 7.1 METAL BINDING DOMAIN OF RAT BETA-AMYLOID · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18080 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 4.6 structure of amyloid precursor protein's transmembrane domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18649 BMRB | nmr_shifts | chemical_shift | in vitro · 39.85 °C · pH 7.2 Transmembrane domain of Amyloid precursor protein WT · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-19701 BMRB | nmr_shifts | chemical_shift | in vitro · 4.85 °C · pH 7 NMR structure of the soluble A 17-34 peptide · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-5735 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C The Solution Structure of Rat Ab-(1-28) and its Interaction with Zinc: Insights into the Scarity of Amyloid Deposition in Aged Rat Brain · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-6236 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 6.4 Backbone 1H, 13C, and 15N Chemical Shift Assignments for CAPPD*, an Independently Folded Extracellular Domain of Human Amyloid-beta Precursor Protein · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-AFDB-AF-P12023-F1 AlphaFold DB | af_prediction | plddt: 67.06 pLDDT | in silico AlphaFold DB prediction AF-P12023-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-770 | unmapped |
| EV-SMASH-SMFS-002089 SMASH-BIO | force_spectroscopy | study_record | in vitro Pseudopeptide Amyloid Aggregation Inhibitors: In Silico, Single Molecule and Cell Viability Studies. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
16 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.