pH-gated potassium channel KcsA
UniProt P0A334 · gene kcsA · Streptomyces lividans · 160 residues
96evidence items
22mapped to a state
3states
4techniques
3sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_structure | nmr_shifts | af_prediction | Total |
|---|---|---|---|---|---|---|
| gate closed, selectivity filter conductive (high K+) KcsA-closed-conductive | observed (one method) | proc 1 | · | · | · | 1 |
| gate closed, selectivity filter collapsed (low K+) KcsA-closed-collapsed | observed (one method) | proc 2 | · | · | · | 2 |
| gate open, filter inactivated KcsA-open-inactivated | observed | proc 17 | proc 2 | · | · | 19 |
Unmapped evidence: 74 of 96 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 6 | 0 |
| RCSB PDB | 89 | 22 |
Curated rules applied
kcsa-low-k-title: 1 itemskcsa-open-title: 18 items
Structure
Choose a state. Each model is badged observed or inferred; assumptions are one click away.
States and transitions
| State | Basis | Parent | Description |
|---|---|---|---|
| gate closed, selectivity filter conductive (high K+) KcsA-closed-conductive | observed | — | Inner gate closed and selectivity filter in the conductive conformation at high K+, as in 1K4C. |
| gate closed, selectivity filter collapsed (low K+) KcsA-closed-collapsed | observed | — | Selectivity filter collapsed at low K+, as in 1K4D. |
| gate open, filter inactivated KcsA-open-inactivated | observed | — | Inner gate open (32 Å at T112) with an inactivated filter, as in 3F5W. |
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1BL8-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · pH 7.5 · ligands K POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS · PROTEIN (POTASSIUM CHANNEL PROTEIN) (chains A,B,C,D) | unmapped |
| EV-PDB-1J95-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 7.5 · ligands K, TBA KCSA potassium channel with TBA (tetrabutylammonium) and potassium · VOLTAGE-GATED POTASSIUM CHANNEL (chains A,B,C,D) | unmapped |
| EV-PDB-1JQ2-1 RCSB PDB | nmr_structure | structure | in vitro · -123.15 °C · pH 7 POTASSIUM CHANNEL (KCSA) OPEN GATE MODEL · VOLTAGE-GATED POTASSIUM CHANNEL (chains A,B,C,D) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-1K4C-3 RCSB PDB | xray | resolution: 2 Å | in vitro · -73.15 °C · pH 5.4 · ligands DGA, F09, K Potassium Channel KcsA-Fab complex in high concentration of K+ · potassium channel KcsA (chains C) | gate closed, selectivity filter conductive (high K+) · curator:draft (unreviewed) · high KcsA-Fab complex at high K+. |
| EV-PDB-1K4D-3 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -73.15 °C · pH 5.4 · ligands DGA, F09, K, NA Potassium Channel KcsA-Fab complex in low concentration of K+ · potassium channel KcsA (chains C) | gate closed, selectivity filter collapsed (low K+) · curator:draft (unreviewed) · high KcsA-Fab complex at low K+. |
| EV-PDB-1R3I-3 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 5.4 · ligands DGA, F09, RB potassium channel KcsA-Fab complex in Rb+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-1R3K-3 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 5.4 · ligands DGA, TL potassium channel KcsA-Fab complex in low concentration of Tl+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-1R3L-3 RCSB PDB | xray | resolution: 2.41 Å | in vitro · -173.15 °C · pH 5.4 · ligands CS, DGA, F09 potassium channel KcsA-Fab complex in Cs+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-1ZWI-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -123.15 °C · ligands DGA, F09, K Structure of mutant KcsA potassium channel · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2A9H-1 RCSB PDB | nmr_structure | structure | in vitro · 41.85 °C · pH 7.5 NMR structural studies of a potassium channel / charybdotoxin complex · Voltage-gated potassium channel (chains A,B,C,D) | unmapped |
| EV-PDB-2ATK-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -123.15 °C · pH 5.4 · ligands F09, K Structure of a mutant KcsA K+ channel · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2BOB-3 RCSB PDB | xray | resolution: 2.76 Å | in vitro · -73.15 °C · pH 5.4 · ligands CO, TBA, TL Potassium channel KcsA-Fab complex in thallium with tetrabutylammonium (TBA) · POTASSIUM CHANNEL KCSA (chains C) | unmapped |
| EV-PDB-2BOC-3 RCSB PDB | xray | resolution: 3.01 Å | in vitro · -73.15 °C · pH 5.4 · ligands CO, T1A, TL Potassium channel KcsA-Fab complex in thallium with tetraethylarsonium (TEAs) · POTASSIUM CHANNEL KCSA (chains C) | unmapped |
| EV-PDB-2DWD-3 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 6.5 · ligands F09, L2C, TBA, TL crystal structure of KcsA-FAB-TBA complex in Tl+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2DWE-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 6.5 · ligands F09, L2C, RB, TBA Crystal structure of KcsA-FAB-TBA complex in Rb+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2H8P-3 RCSB PDB | xray | resolution: 2.25 Å | in vitro · pH 6.5 · ligands B3H, K Structure of a K channel with an amide to ester substitution in the selectivity filter · KcsA Channel (chains C) | unmapped |
| EV-PDB-2HG5-3 RCSB PDB | xray | resolution: 2.75 Å | in vitro · -173.15 °C · pH 6.5 · ligands B3H, CS Cs+ complex of a K channel with an amide to ester substitution in the selectivity filter · KCSA CHANNEL (chains C) | unmapped |
| EV-PDB-2HJF-3 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -173.15 °C · pH 5.2 · ligands K, TBA Potassium channel kcsa-fab complex with tetrabutylammonium (TBA) · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2HVJ-3 RCSB PDB | xray | resolution: 2.75 Å | in vitro · -173.15 °C · pH 6.5 · ligands F09, K, L2C, TBA Crystal structure of KcsA-Fab-TBA complex in low K+ · Voltage-gated potassium channel (chains C) | gate closed, selectivity filter collapsed (low K+) · rule:kcsa-low-k-title · medium Title describes low K+ conditions, where the filter collapses. |
| EV-PDB-2HVK-3 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands F09, K, L2C, TBA crystal structure of the KcsA-Fab-TBA complex in high K+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2IH3-3 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · pH 6 · ligands 1EM, K Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2ITC-3 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -73.15 °C · pH 7 · ligands NA Potassium Channel KcsA-Fab complex in Sodium Chloride · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2ITD-3 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -73.15 °C · pH 6.2 · ligands BA Potassium Channel KcsA-Fab complex in Barium Chloride · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2JK5-3 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 5.4 · ligands CO, F09, HP6, K, L2C, TBA Potassium Channel KcsA in complex with Tetrabutylammonium in high K · VOLTAGE-GATED POTASSIUM CHANNEL (chains C) | unmapped |
| EV-PDB-2P7T-3 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · ligands 1EM, F09, K Crystal Structure of KcsA mutant · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2QTO-1 RCSB PDB | xray | resolution: 3.201 Å | in vitro · -173.15 °C · pH 7.5 · ligands K An anisotropic model for potassium channel KcsA · Voltage-gated potassium channel (chains A,B,C,D) | unmapped |
| EV-PDB-2W0F-3 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 5.4 · ligands CO, DGA, F09, HX0, K Potassium Channel KcsA-Fab Complex with Tetraoctylammonium · VOLTAGE-GATED POTASSIUM CHANNEL (chains C) | unmapped |
| EV-PDB-3F5W-3 RCSB PDB | xray | resolution: 3.3 Å | in vitro · -173.15 °C · pH 6 · ligands K KcsA Potassium channel in the open-inactivated state with 32 A opening at T112 · Voltage-gated potassium channel (chains C) | gate open, filter inactivated · curator:draft (unreviewed) · high Title: open-inactivated state, 32 Å opening at T112. |
| EV-PDB-3F7V-3 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · ligands K KcsA Potassium channel in the open-inactivated state with 23 A opening at T112 · Voltage-gated potassium channel (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-3FB5-3 RCSB PDB | xray | resolution: 2.8 Å | in vitro · ligands K KcsA potassium channel in the partially open state with 14.5 A opening at T112 · Voltage-gated potassium channel (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-3FB6-3 RCSB PDB | xray | resolution: 3 Å | in vitro · ligands K KcsA Potassium channel in the partially open state with 16 A opening at T112 · Voltage-gated potassium channel (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-3FB7-3 RCSB PDB | xray | resolution: 3.3 Å | in vitro · ligands RB Open KcsA potassium channel in the presence of Rb+ ion · Voltage-gated potassium channel (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-3FB8-3 RCSB PDB | xray | resolution: 3.4 Å | in vitro · ligands RB KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion · Voltage-gated potassium channel (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-3GB7-3 RCSB PDB | xray | resolution: 2.85 Å | in vitro · pH 5.5 · ligands DGA, NI Potassium Channel KcsA-Fab complex in Li+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-3HPL-3 RCSB PDB | xray | resolution: 3.2 Å | in vitro · ligands K KcsA E71H-F103A mutant in the closed state · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-3OGC-3 RCSB PDB | xray | resolution: 3.8 Å | in vitro · -180.15 °C · pH 6.5 · ligands NA KcsA E71A variant in presence of Na+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-3OR6-3 RCSB PDB | xray | resolution: 2.7 Å | in vitro · pH 6 · ligands K On the structural basis of modal gating behavior in K+channels - E71Q · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-3OR7-3 RCSB PDB | xray | resolution: 2.3 Å | in vitro · pH 6 · ligands K On the structural basis of modal gating behavior in K+channels - E71I · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-3PJS-3 RCSB PDB | xray | resolution: 3.8 Å | in vitro · -173.15 °C · pH 7.5 Mechanism of Activation Gating in the Full-Length KcsA K+ Channel · Voltage-gated potassium channel (chains K,L,M,N) | unmapped |
| EV-PDB-3STL-3 RCSB PDB | xray | resolution: 2.4 Å | in vitro · pH 5.5 · ligands CD, K KcsA potassium channel mutant Y82C with Cadmium bound · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-3IGA-3 RCSB PDB | xray | resolution: 2.75 Å | in vitro · ligands DGA, NI Potassium Channel KcsA-Fab complex in Li+ and K+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-3IFX-1 RCSB PDB | xray | resolution: 3.56 Å | in vitro · -173.15 °C · pH 7.5 · ligands K, MTN, TBA Crystal structure of the Spin-labeled KcsA mutant V48R1 · Voltage-gated potassium channel (chains A,B,C,D) | unmapped |
| EV-PDB-3F7Y-3 RCSB PDB | xray | resolution: 3.4 Å | in vitro · ligands K KcsA Potassium channel in the partially open state with 17 A opening at T112 · Voltage-gated potassium channel (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-3EFF-3 RCSB PDB | xray | resolution: 3.8 Å | in vitro · pH 5.6 The Crystal Structure of Full-Length KcsA in its Closed Conformation · Voltage-gated potassium channel (chains K,L,M,N) | unmapped |
| EV-PDB-2NLJ-3 RCSB PDB | xray | resolution: 2.52 Å | in vitro · -73.15 °C · pH 6.5 · ligands DGA, K Potassium Channel KcsA(M96V)-Fab complex in KCl · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-2IH1-3 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 5.5 · ligands 1EM, K Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-1R3J-3 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 5.4 · ligands DGA, F09, TL potassium channel KcsA-Fab complex in high concentration of Tl+ · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-1JVM-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 7.5 · ligands RB, TBA KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND RUBIDIUM · Voltage-gated potassium channel (chains A,B,C,D) | unmapped |
| EV-PDB-1JQ1-1 RCSB PDB | nmr_structure | structure | in vitro · -123.15 °C · pH 7 POTASSIUM CHANNEL (KCSA) OPEN GATE MODEL · VOLTAGE-GATED POTASSIUM CHANNEL (chains A,B,C,D) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-1F6G-1 RCSB PDB | nmr_structure | structure | in vitro · 19.85 °C · pH 7.2 POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD · VOLTAGE-GATED POTASSIUM CHANNEL (chains A,B,C,D) | unmapped |
| EV-PDB-3STZ-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · pH 5.5 · ligands K, MTN KcsA potassium channel mutant Y82C with nitroxide spin label · Voltage-gated potassium channel (chains C) | unmapped |
| EV-PDB-4LBE-3 RCSB PDB | xray | resolution: 2.751 Å | in vitro · -80.15 °C · pH 6.5 · ligands DGA, F09, K Structure of KcsA with R122A mutation · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-4LCU-3 RCSB PDB | xray | resolution: 2.752 Å | in vitro · -180.15 °C · pH 6.5 · ligands DGA, K Structure of KcsA with E118A mutation · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-4MSW-3 RCSB PDB | xray | resolution: 2.06 Å | in vitro · ligands DGA, K Y78 ester mutant of KcsA in high K+ · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-4UUJ-3 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 5.4 · ligands CO, DGA, F09, IND, K, PO4, XA7 POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM · VOLTAGE-GATED POTASSIUM CHANNEL KCSA (chains C) | unmapped |
| EV-PDB-5E1A-3 RCSB PDB | xray | resolution: 3.4 Å | in vitro · -173.15 °C · pH 6.75 · ligands K Structure of KcsA with L24C/R117C mutations · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5EBL-3 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -193.15 °C · ligands DGA, F09, K KcsA T75G in the Conductive State · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5EBM-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -193.15 °C · ligands DGA, F09, K KcsA T75G mutant in the nonconductive state · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5EBW-3 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -193.15 °C · ligands DGA, F09, K KcsA with G77ester mutation · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5EC2-3 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -193.15 °C · ligands DGA, F09, K KcsA with V76ester+G77dA mutations · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5J9P-3 RCSB PDB | xray | resolution: 2.85 Å | in vitro · -193.15 °C · ligands K KcsA in vitro · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5VKE-3 RCSB PDB | xray | resolution: 2.37 Å | in vitro · -123.15 °C · ligands 1EM, F09, K Open conformation of KcsA deep-inactivated · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-6PA0-3 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · ligands DGA, F09, NA Structure of the G77A mutant in Sodium Chloride · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-6W0A-3 RCSB PDB | xray | resolution: 3.237 Å | in vitro · -175.15 °C · pH 5.5 · ligands BA, K Open-gate KcsA soaked in 1 mM BaCl2 · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-6W0C-3 RCSB PDB | xray | resolution: 3.556 Å | in vitro · -175.15 °C · pH 5.5 · ligands BA, K Open-gate KcsA soaked in 4 mM BaCl2 · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-6W0D-3 RCSB PDB | xray | resolution: 3.639 Å | in vitro · -175.15 °C · pH 5.5 · ligands BA, K Open-gate KcsA soaked in 5 mM BaCl2 · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-6W0E-3 RCSB PDB | xray | resolution: 3.512 Å | in vitro · -175.15 °C · pH 5.5 · ligands BA, K Open-gate KcsA soaked in 10 mM BaCl2 · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-6W0F-3 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -175.15 °C · pH 5.5 · ligands K Closed-gate KcsA soaked in 0mM KCl/5mM BaCl2 · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-6W0G-3 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -175.15 °C · pH 5.5 · ligands K Closed-gate KcsA soaked in 1mM KCl/5mM BaCl2 · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-6W0I-3 RCSB PDB | xray | resolution: 2.328 Å | in vitro · -175.15 °C · pH 5.5 · ligands K Closed-gate KcsA soaked in 10mM KCl/5mM BaCl2 · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-6W0J-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -175.15 °C · pH 5.5 · ligands BA Closed-gate KcsA incubated in BaCl2/NaCl · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-7M2J-3 RCSB PDB | xray | resolution: 3.201 Å | in vitro · -180.15 °C · pH 6.5 · ligands K Structural Snapshots of Intermediates in the Gating of a K+ Channel · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-7MDJ-3 RCSB PDB | xray | resolution: 2.75 Å | in vitro · -173.15 °C · pH 5.5 · ligands K The structure of KcsA in complex with a synthetic Fab · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-7MHX-3 RCSB PDB | xray | resolution: 2.85 Å | in vitro · -175.15 °C · ligands BA, DGA KcsA E71V closed gate with Ba2+ · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-7MK6-3 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -175.15 °C KcsA open gate E71V mutant with sodium · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-7RP0-3 RCSB PDB | xray | resolution: 2.48 Å | in vitro · -173.15 °C · pH 6.25 · ligands DGA, F09, K, TBA Structural Snapshots of Intermediates in the Gating of a K+ Channel · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-8THN-3 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -173.15 °C · pH 6.25 · ligands K, TBA KcsA M96V mutant with Y78ester in High K+ · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-7MUB-3 RCSB PDB | xray | resolution: 3 Å | in vitro · -175.15 °C · ligands K KcsA Open gate E71V mutant in Potassium · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-7MJT-3 RCSB PDB | xray | resolution: 3.3 Å | in vitro · -175.15 °C · ligands BA KcsA open gate E71V mutant with Barium · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-7MHR-3 RCSB PDB | xray | resolution: 2.77 Å | in vitro · -175.15 °C · ligands K KcsA E71V closed gate with K+ · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-7M2I-3 RCSB PDB | xray | resolution: 2.695 Å | in vitro · -180.15 °C · pH 6 · ligands 1EM, F09, K Structural Snapshots of Intermediates in the Gating of a K+ Channel · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-7M2H-3 RCSB PDB | xray | resolution: 2.642 Å | in vitro · -173.15 °C · pH 6.25 · ligands DGA, F09, K, TBA Structural Snapshots of Intermediates in the Gating of a K+ Channel · pH-gated potassium channel KcsA (chains C,F) | unmapped |
| EV-PDB-6W0H-3 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -175.15 °C · pH 5.5 · ligands K Closed-gate KcsA soaked in 5mM KCl/5mM BaCl2 · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-6W0B-3 RCSB PDB | xray | resolution: 3.604 Å | in vitro · -175.15 °C · pH 5.5 · ligands BA, K Open-gate KcsA soaked in 2 mM BaCl2 · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-6NFV-3 RCSB PDB | xray | resolution: 2.13 Å | in vitro · -173.15 °C · ligands 1EM, F09, K Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-6NFU-3 RCSB PDB | xray | resolution: 2.09 Å | in vitro · -173.15 °C · ligands 1EM, F09, K Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5VKH-3 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · ligands 1EM, F09, K Closed conformation of KcsA Y82A-F103A mutant · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-PDB-5VK6-3 RCSB PDB | xray | resolution: 2.25 Å | in vitro · 19.85 °C · ligands 1EM, F09, K Open conformation of KcsA non-inactivating E71A mutant · pH-gated potassium channel KcsA (chains C) | gate open, filter inactivated · rule:kcsa-open-title · medium Title describes an open or partially open gate. |
| EV-PDB-5EC1-3 RCSB PDB | xray | resolution: 2.75 Å | in vitro · -193.15 °C · ligands DGA, F09, K KcsA with V76ester mutation · pH-gated potassium channel KcsA (chains C) | unmapped |
| EV-BMRB-15853 BMRB | nmr_shifts | chemical_shift | in vitro · 49.85 °C · pH 4.2 Local and global structure of the monomeric subunit of the potassium channel KcsA probed by NMR · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-27676 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7 1H/13C/15N Assignments for the TM domains of the KcsA potassium channel · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-27678 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7 1H/13C/15N Assignments for the TM domains of the KcsA potassium channel · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-27679 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7 1H/13C/15N Assignments for the TM domains of the KcsA potassium channel · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-27680 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7 1H/13C/15N Assignments for the TM domains of the KcsA potassium channel · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-7428 BMRB | nmr_shifts | chemical_shift | in vitro · 49.85 °C · pH 6 Local and global structure of the monomeric subunit of the potassium channel KcsA probed by NMR · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-P0A334-F1 AlphaFold DB | af_prediction | plddt: 89.62 pLDDT | in silico AlphaFold DB prediction AF-P0A334-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-160 | unmapped |
Conflicts
No conflicts found among comparable evidence.
96 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.
Downloads
- Protein bundle (JSON)
- KcsA-closed-conductive-cif (mmCIF, observed)
- KcsA-closed-conductive-pdb (PDB, observed)
- KcsA-closed-collapsed-cif (mmCIF, observed)
- KcsA-closed-collapsed-pdb (PDB, observed)
- KcsA-open-inactivated-cif (mmCIF, observed)
- KcsA-open-inactivated-pdb (PDB, observed)
- Curation file (YAML)