Integrin beta-1
UniProt P09055 · gene Itgb1 · Mus musculus · 798 residues
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|
| No states defined yet. | ||||||
Unmapped evidence: 15 of 15 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 1 | 0 |
| RCSB PDB | 3 | 0 |
| SMASH-BIO | 10 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-5XQ0-1 RCSB PDB | xray | resolution: 2.75 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL Structural basis of kindlin-mediated integrin recognition and activation · Fermitin family homolog 2,Integrin beta-1 (chains A,B) | unmapped |
| EV-PDB-8TEC-2 RCSB PDB | xray | resolution: 2.04 Å | in vitro · -173.15 °C · pH 8.5 Crystal structure of Kindlin2 in complex with acylated beta1 integrin peptide · Integrin beta-1 (chains C) | unmapped |
| EV-PDB-8TEE-2 RCSB PDB | xray | resolution: 2.49 Å | in vitro · -173.15 °C Crystal structure of Kindlin2 in complex with K794Q mutated beta1 integrin · Integrin beta-1 (chains C,D) | unmapped |
| EV-BMRB-16159 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.1 Beta1A Integrin Cytoplasmic Tail 1H and 15N Chemical Shift Assignments · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-P09055-F1 AlphaFold DB | af_prediction | plddt: 85.94 pLDDT | in silico AlphaFold DB prediction AF-P09055-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-798 | unmapped |
| EV-SMASH-SMFS-000423 SMASH-BIO | force_spectroscopy | study_record | in vitro Direct Binding of Lyn to GPIbβ Transmits 2-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding. · Integrin; biomembrane force probe; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001065 SMASH-BIO | force_spectroscopy | study_record | in vitro Biphasic reinforcement of nascent adhesions by vinculin. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-002602 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8.8 αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004432 SMASH-BIO | force_spectroscopy | study_record | in vitro Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-004869 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.6 Force mapping during the formation and maturation of cell adhesion sites with multiple optical tweezers. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005949 SMASH-BIO | force_spectroscopy | study_record | in vitro The influence of Pyk2 on the mechanical properties in fibroblasts. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005974 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 What is vinculin needed for in platelets? · Integrin; optical tweezers; experiment class: force_generation_polymerization, membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006009 SMASH-BIO | force_spectroscopy | study_record | in vitro Comparing the mechanical influence of vinculin, focal adhesion kinase and p53 in mouse embryonic fibroblasts. · Integrin; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006380 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechano-coupling and regulation of contractility by the vinculin tail domain. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-007470 SMASH-BIO | force_spectroscopy | study_record | in vitro Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
Conflicts
No conflicts found among comparable evidence.
15 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.