Type 1 fimbrin D-mannose specific adhesin
UniProt P08191 · gene fimH · Escherichia coli (strain K12) · 300 residues
102evidence items
0mapped to a state
0states
6techniques
4sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_dynamics | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 102 of 102 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 3 | 0 |
| RCSB PDB | 83 | 0 |
| SMASH-BIO | 15 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1KIU-2 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C · pH 8.2 · ligands MMA FimH adhesin Q133N mutant-FimC chaperone complex with methyl-alpha-D-mannose · FimH PROTEIN (chains B,D,F,H,J,L,N,P) | unmapped |
| EV-PDB-1KLF-2 RCSB PDB | xray | resolution: 2.79 Å | in vitro · -173.15 °C · pH 8.2 · ligands MAN FIMH ADHESIN-FIMC CHAPERONE COMPLEX WITH D-MANNOSE · FIMH PROTEIN (chains B,D,F,H,J,L,N,P) | unmapped |
| EV-PDB-1QUN-2 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -100.15 °C · pH 8.4 X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI · MANNOSE-SPECIFIC ADHESIN FIMH (chains B,D,F,H,J,L,N,P) | unmapped |
| EV-PDB-1TR7-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands CAC, DEG, MPD FimH adhesin receptor binding domain from uropathogenic E. coli · FimH protein (chains A,B) | unmapped |
| EV-PDB-1ZE3-2 RCSB PDB | xray | resolution: 1.84 Å | in vitro · -173.15 °C · pH 6.5 · ligands EDO Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH · FimH protein (chains H) | unmapped |
| EV-PDB-2VCO-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 8.5 · ligands NI, SO4, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Crystal structure of the fimbrial adhesin FimH in complex with its high-mannose epitope · PROTEIN FIMH (chains A,B) | unmapped |
| EV-PDB-3RFZ-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -196.15 °C · pH 8.5 · ligands SO4 Crystal structure of the FimD usher bound to its cognate FimC:FimH substrate · Type 1 fimbrial adhesin (chains A,D) | unmapped |
| EV-PDB-3ZL1-1 RCSB PDB | xray | resolution: 1.551 Å | in vitro · -173.15 °C · pH 7.5 · ligands BWG, CL A thiazolyl-mannoside bound to FimH, monoclinic space group · PROTEIN FIMH (chains A,B) | unmapped |
| EV-PDB-4ATT-1 RCSB PDB | xray | resolution: 1.251 Å | in vitro · -173.15 °C · ligands HNV FimH lectin domain co-crystal with a alpha-D-mannoside O-linked to a propynyl para methoxy phenyl · FIMH (chains A) | unmapped |
| EV-PDB-4AUJ-1 RCSB PDB | xray | resolution: 1.527 Å | in vitro · -173.15 °C · ligands HNW FimH lectin domain co-crystal with a alpha-D-mannoside O-linked to para hydroxypropargyl phenyl · FIMH (chains A) | unmapped |
| EV-PDB-4AV0-1 RCSB PDB | xray | resolution: 2.099 Å | in vitro · -173.15 °C · pH 8.6 · ligands HNV, NI, SO4 Structure of the FimH lectin domain in the trigonal space group, in complex with a methoxy phenyl propynyl alpha-D-mannoside at 2.1 A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-4AV5-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 7.4 · ligands FYZ, SO4 Structure of a triclinic crystal of the FimH lectin domain in complex with a propynyl biphenyl alpha-D-mannoside, at 1.4 A resolution · FIMH (chains A,B,C,D) | unmapped |
| EV-PDB-4AVI-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 8.6 · ligands NI, SO4, XNS Structure of the FimH lectin domain in the trigonal space group, in complex with a methyl ester octyl alpha-D-mannoside at 2.4 A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-4CSS-1 RCSB PDB | xray | resolution: 1.069 Å | in vitro · -173.15 °C · pH 4.7 · ligands CWX, GOL Crystal structure of FimH in complex with a sulfonamide biphenyl alpha D-mannoside · PROTEIN FIMH (chains A) | unmapped |
| EV-PDB-4CST-1 RCSB PDB | xray | resolution: 1.1 Å | in vitro · -173.15 °C · ligands CWK Crystal structure of FimH in complex with 3'-Chloro-4'-(alpha-D-mannopyranosyloxy)-biphenyl-4-carbonitrile · PROTEIN FIMH (chains A) | unmapped |
| EV-PDB-4J3O-2 RCSB PDB | xray | resolution: 3.8 Å | in vitro · -173.15 °C · pH 8.5 Crystal structure of the FimD usher traversed by the pilus tip complex assembly composed of FimC:FimF:FimG:FimH · Protein FimH (chains H) | unmapped |
| EV-PDB-4X5P-1 RCSB PDB | xray | resolution: 0.997 Å | in vitro · -173.15 °C · pH 4.7 · ligands 3XJ Crystal structure of FimH in complex with a benzoyl-amidophenyl alpha-D-mannopyranoside · Protein FimH (chains A) | unmapped |
| EV-PDB-4X5Q-1 RCSB PDB | xray | resolution: 1.12 Å | in vitro · -173.15 °C · pH 4.7 · ligands 3XN Crystal structure of FimH in complex with 5-nitro-indolinylphenyl alpha-D-mannopyranoside · Protein FimH (chains A) | unmapped |
| EV-PDB-4X5R-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 7 · ligands 3XO, SO4 Crystal structure of FimH in complex with a squaryl-phenyl alpha-D-mannopyranoside derivative · Protein FimH (chains A,B,C) | unmapped |
| EV-PDB-4XO8-1 RCSB PDB | xray | resolution: 1.698 Å | in vitro · -173.15 °C · pH 5.5 · ligands KGM Crystal structure of the FimH lectin domain from E.coli K12 in complex with heptyl alpha-D-mannopyrannoside · Protein FimH (chains A,B) | unmapped |
| EV-PDB-4XO9-1 RCSB PDB | xray | resolution: 1.14 Å | in vitro · -173.15 °C · pH 5.5 Crystal structure of a FimH*DsG complex from E.coli K12 in space group C2 · Protein FimH (chains A) | unmapped |
| EV-PDB-4XOB-1 RCSB PDB | xray | resolution: 3.003 Å | in vitro · -173.15 °C · pH 6.5 · ligands KGM, SO4 Crystal structure of a FimH*DsF complex from E.coli K12 with bound heptyl alpha-D-mannopyrannoside · Protein FimH (chains A,C,E,G) | unmapped |
| EV-PDB-4XOC-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · pH 7.5 · ligands KGM Crystal structure of the FimH lectin domain from E.coli F18 in complex with heptyl alpha-D-mannopyrannoside · FimH protein (chains A,B) | unmapped |
| EV-PDB-4XOD-2 RCSB PDB | xray | resolution: 1.14 Å | in vitro · -173.15 °C · pH 5.5 Crystal structure of a FimH*DsG complex from E.coli F18 · FimH protein (chains A) | unmapped |
| EV-PDB-4XOE-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 6.5 · ligands CAC, KGM Crystal structure of a FimH*DsG complex from E.coli F18 with bound heptyl alpha-D-mannopyrannoside · FimH protein (chains A) | unmapped |
| EV-PDB-5ABZ-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 8.6 · ligands NI, Z47 Complex of the FimH lectin with a C-linked naphtyl alpha-D-mannoside in soaked trigonal crystals at 2.40 A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-5CGB-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 5.5 · ligands 51C, SO4 Crystal structure of FimH in complex with heptyl alpha-D-septanoside · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5F2F-1 RCSB PDB | xray | resolution: 1.665 Å | in vitro · -173.15 °C · pH 5.8 · ligands 5U7, GOL Crystal structure of para-biphenyl-2-methyl-3', 5' di-methyl amide mannoside bound to FimH lectin domain · Protein FimH (chains A) | unmapped |
| EV-PDB-5FS5-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · pH 6.5 · ligands KGM, NA Breaking down the wall: mutation of the tyrosine gate of the universal Escherichia coli fimbrial adhesin FimH · FIMH (chains A) | unmapped |
| EV-PDB-5FWR-1 RCSB PDB | xray | resolution: 2.13 Å | in vitro · -173.15 °C · pH 7.8 · ligands 3X8 Breaking down the wall: mutation of the tyrosine gate of the universal Escherichia coli fimbrial adhesin FimH · FimH (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-5FX3-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7.5 · ligands EDT Breaking down the wall: mutation of the tyrosine gate of the universal Escherichia coli fimbrial adhesin FimH · FimH (chains A) | unmapped |
| EV-PDB-5L4T-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 6LS Crystal structure of FimH lectin domain in complex with 2-Deoxy-Heptylmannoside · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5L4X-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 6KU Crystal structure of FimH lectin domain in complex with 4-Deoxy-Heptylmannoside · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5L4W-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 6KH Crystal structure of FimH lectin domain in complex with 3-Fluoro-Heptylmannoside · Protein FimH (chains A,B,C) | unmapped |
| EV-PDB-5L4V-1 RCSB PDB | xray | resolution: 2.99 Å | in vitro · -173.15 °C · ligands 6KW Crystal structure of FimH lectin domain in complex with 3-Deoxy-Heptylmannoside · Protein FimH (chains A,B,C) | unmapped |
| EV-PDB-5L4U-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands 6KS Crystal structure of FimH lectin domain in complex with 2-Fluoro-Heptylmannoside · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5JCR-1 RCSB PDB | xray | resolution: 1.701 Å | in vitro · -173.15 °C · ligands MMA Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl alpha-D-mannopyrannoside in spacegroup P212121 · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5JCQ-1 RCSB PDB | xray | resolution: 1.602 Å | in vitro · -173.15 °C · ligands MMA, SO4 Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl alpha-D-mannopyrannoside in spacegroup P21 · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5F3F-1 RCSB PDB | xray | resolution: 1.76 Å | in vitro · -173.15 °C · pH 5.8 · ligands 5US Crystal structure of para-biphenyl-2-methyl-3'-methyl amide mannoside bound to FimH lectin domain · Protein FimH (chains A) | unmapped |
| EV-PDB-4XOA-2 RCSB PDB | xray | resolution: 2.541 Å | in vitro · -173.15 °C · pH 5 Crystal structure of a FimH*DsG complex from E.coli K12 in space group P1 · Protein FimH (chains A,C,E,G) | unmapped |
| EV-PDB-4X50-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7 · ligands 3X8 Crystal structure of FimH in complex with biphenyl alpha-D-mannopyranoside · Protein FimH (chains A,B) | unmapped |
| EV-PDB-4LOV-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands GOL, KGM, NA Crystal structure of FimH in complex with Heptylmannoside · Protein FimH (chains A) | unmapped |
| EV-PDB-4AVK-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 8.6 · ligands FVQ, NI, SO4 Structure of trigonal FimH lectin domain crystal soaked with an alpha- D-mannoside O-linked to propynyl pyridine at 2.4A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-4AVJ-1 RCSB PDB | xray | resolution: 2.105 Å | in vitro · -173.15 °C · pH 8.6 · ligands J73, NI, SO4 Structure of the FimH lectin domain in the trigonal space group, in complex with a methanol triazol ethyl phenyl alpha-D-mannoside at 2.1 A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-4AVH-1 RCSB PDB | xray | resolution: 2.105 Å | in vitro · -173.15 °C · pH 8.6 · ligands FK9, NI, SO4 Structure of the FimH lectin domain in the trigonal space group, in complex with a thioalkyl alpha-D-mannoside at 2.1 A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-4AV4-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8.6 · ligands FVQ FimH lectin domain co-crystal with a alpha-D-mannoside O-linked to a propynyl pyridine · FIMH (chains A) | unmapped |
| EV-PDB-4AUY-1 RCSB PDB | xray | resolution: 2.102 Å | in vitro · -173.15 °C · pH 8.6 · ligands HNW, NI, SO4 Structure of the FimH lectin domain in the trigonal space group, in complex with an hydroxyl propynyl phenyl alpha-D-mannoside at 2.1 A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-4AUU-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8.6 · ligands EDO, NI, SO4 Crystal structure of apo FimH lectin domain at 1.5 A resolution · FIMH (chains A,B) | unmapped |
| EV-PDB-3ZL2-1 RCSB PDB | xray | resolution: 1.251 Å | in vitro · -173.15 °C · pH 6.5 · ligands BWG A thiazolyl-mannoside bound to FimH, orthorhombic space group · PROTEIN FIMH (chains A) | unmapped |
| EV-PDB-1UWF-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · pH 7.5 · ligands DEG, GOL 1.7 A resolution structure of the receptor binding domain of the FimH adhesin from uropathogenic E. coli · FIMH PROTEIN (chains A) | unmapped |
| EV-PDB-5L4Y-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 6K3 Crystal structure of FimH lectin domain in complex with 4-Fluoro-Heptylmannoside · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5MCA-1 RCSB PDB | xray | resolution: 1.604 Å | in vitro · -173.15 °C · ligands SO4 Crystal structure of FimH-LD R60P variant in the apo state · Protein FimH (chains A) | unmapped |
| EV-PDB-5MTS-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 8.5 · ligands NI, XKA Complex of FimH lectin with a TazMan (thiazolylaminomannosides) family member known as potent anti-adhesive agent at 2.6 A resolution · Protein FimH (chains A,B) | unmapped |
| EV-PDB-5MUC-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · ligands AH2 Crystal structure of the FimH lectin domain in complex with 1,5-Anhydromannitol · Protein FimH (chains A,B) | unmapped |
| EV-PDB-6E14-1 RCSB PDB | cryoem | resolution: 4 Å | in vitro Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD · Type 1 fimbrin D-mannose specific adhesin (chains H) | unmapped |
| EV-PDB-6E15-5 RCSB PDB | cryoem | resolution: 5.1 Å | in vitro Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD · Type 1 fimbrin D-mannose specific adhesin (chains H) | unmapped |
| EV-PDB-6G2R-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands EJK, EPE, SO4 Crystal structure of FimH in complex with a tetraflourinated biphenyl alpha D-mannoside · Type 1 fimbrin D-mannose specific adhesin (chains A,B) | unmapped |
| EV-PDB-6G2S-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands EJN, SO4 Crystal structure of FimH in complex with a pentaflourinated biphenyl alpha D-mannoside · Type 1 fimbrin D-mannose specific adhesin (chains A,B,C,D,E,F,G,H,I) | unmapped |
| EV-PDB-6GTX-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · ligands SO4, branched: alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-2)Man · Type 1 fimbrin D-mannose specific adhesin (chains A,B,C,D) | unmapped |
| EV-PDB-6GTY-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands branched: alpha-D-mannopyranose-(1-6)-methyl alpha-D-mannopyranoside Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-6)Man · Type 1 fimbrin D-mannose specific adhesin (chains A,B,C,D,E) | unmapped |
| EV-PDB-6YHW-1 RCSB PDB | xray | resolution: 1.962 Å | in vitro · -173.15 °C · pH 6.5 · ligands HP6, MAN, TA5, branched: Cycloheptakis-(1-4)-(alpha-D-glucopyranose) Co-crystals in the P212121 space group, of a beta-cyclodextrin spacered by triazole heptyl from alpha-D-mannose, with FimH lectin at 2.00 A resolution. · FimH (chains A,B) | unmapped |
| EV-PDB-7AYN-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · ligands EDO, SBQ Crystal structure of the lectin domain of the FimH variant Arg98Ala, in complex with Methyl 3-chloro-4-D-mannopyranosyloxy-3-biphenylcarboxylate · Type 1 fimbrin D-mannose specific adhesin (chains A,B,C,D) | unmapped |
| EV-PDB-7BHD-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 9 · ligands NI, SO4, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose FimH in complex with alpha1,6 core-fucosylated oligomannose-3, crystallized in the trigonal space group · Type 1 fimbrin D-mannose specific adhesin (chains A,B) | unmapped |
| EV-PDB-7QUO-1 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C · pH 8.5 · ligands NI, SO4, branched: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose FimH lectin domain in complex with oligomannose-6 · FimH (chains A,B,C,D) | unmapped |
| EV-PDB-7SZO-4 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · ligands GOL Structure of a bacterial fimbrial tip containing FocH · FimH,F1C putative fimbrial adhesin fusion (chains H,N) | unmapped |
| EV-PDB-8BVD-1 RCSB PDB | xray | resolution: 2.995 Å | in vitro · -173.15 °C · pH 5.5 · ligands RLO FimH lectin domain in complex with mannose C-linked to quinoline · Type 1 fimbrin D-mannose specific adhesin (chains A,B,C,D) | unmapped |
| EV-PDB-8BXY-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 9 · ligands NI, SO4, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose FimH in complex with alpha1,6 core-fucosylated oligomannose-3, crystallized in the trigonal space group · Type 1 fimbrin D-mannose specific adhesin (chains A,B) | unmapped |
| EV-PDB-8BY3-1 RCSB PDB | xray | resolution: 3.186 Å | in vitro · -173.15 °C · pH 8.5 · ligands NI, SO4, branched: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose FimH lectin domain in complex with oligomannose-6 · Type 1 fimbrin D-mannose specific adhesin (chains A,B,C,D) | unmapped |
| EV-PDB-8V3J-1 RCSB PDB | xray | resolution: 1.898 Å | in vitro · -173.15 °C · pH 4.5 · ligands NAG Structure-Based Engineering of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine · Type 1 fimbrin D-mannose specific adhesin,Protein FimG (chains A,B,C,D) | unmapped |
| EV-PDB-8V93-4 RCSB PDB | cryoem | resolution: 3.12 Å | in vitro Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 329-2 and 454-3 · Type 1 fimbrin D-mannose specific adhesin FimH, Donor strand complemented with FimG peptide 'triple mutant' (chains D) | unmapped |
| EV-PDB-9BOG-4 RCSB PDB | cryoem | resolution: 3.99 Å | in vitro Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili · Type 1 fimbrin D-mannose specific adhesin (chains H) | unmapped |
| EV-PDB-9CCS-1 RCSB PDB | cryoem | resolution: 3.17 Å | in vitro CryoEM Structure of Escherichia coli FimCH in complex with 2H04 Fab · Type 1 fimbiral adhesin FimH (chains A) | unmapped |
| EV-PDB-9CCT-1 RCSB PDB | cryoem | resolution: 3.46 Å | in vitro CryoEM Structure of Escherichia coli FimCH in complex with B7 Fab · Type 1 fimbiral adhesin FimH (chains A) | unmapped |
| EV-PDB-9CCU-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro CryoEM Structure of Escherichia coli FimCH in complex with F7 Fab · Type 1 fimbiral adhesin FimH (chains A) | unmapped |
| EV-PDB-9CCW-1 RCSB PDB | cryoem | resolution: 3.69 Å | in vitro CryoEM Structure of Escherichia coli FimCH in complex with 2C07 Fab · Type 1 fimbiral adhesin FimH (chains A) | unmapped |
| EV-PDB-9D6F-5 RCSB PDB | cryoem | resolution: 4.24 Å | in vitro Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 440-2 and 454-3 · Type 1 fimbrin D-mannose specific adhesin FimH, Donor strand complemented with FimG peptide 'triple mutant' (chains D) | unmapped |
| EV-PDB-9FY9-5 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro Cryo-EM structure of the type 1 chaperone-usher pilus FimD-tip complex (FimDHGFC) - Conformer 1 · Type 1 fimbrin D-mannose specific adhesin (chains H) | unmapped |
| EV-PDB-9ME4-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Antibody fragments from mAb475 and mAb824 bound to the adhesin protein FimH · Type 1 fimbrin D-mannose specific adhesin (chains A) | unmapped |
| EV-PDB-9ME6-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Antibody fragments from mAb21, mAb475, and mAb824 bound to the adhesin protein FimH · Type 1 fimbrin D-mannose specific adhesin (chains A) | unmapped |
| EV-PDB-9ME7-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands MMA Antibody fragments from mAb21 and mAb824 bound to the adhesin protein FimH containing alpha-methyl mannose · Type 1 fimbrin D-mannose specific adhesin (chains A) | unmapped |
| EV-PDB-9PTM-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro Antibody fragment from mAb824 bound to the adhesin protein FimH. · Type 1 fimbrin D-mannose specific adhesin (chains A) | unmapped |
| EV-PDB-9Q1V-2 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 7 Crystal Structure of de novo design FimH minibinder F7 complex · Type 1 fimbrin D-mannose specific adhesin (chains B,D) | unmapped |
| EV-PDB-9ME5-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro Antibody fragments from mAb824 and mAb926 bound to the adhesin protein FimH · Type 1 fimbrin D-mannose specific adhesin (chains A) | unmapped |
| EV-BMRB-19066 BMRB | nmr_dynamics | relaxation_rate | in vitro · 24.85 °C · pH 6 Solution structure of the FimH adhesin carbohydrate-binding domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts, T1 relaxation values, T2 relaxation values | unmapped |
| EV-BMRB-19256 BMRB | nmr_dynamics | relaxation_rate | in vitro · 24.85 °C · pH 6 NMR assignments and backbone amide relaxation data (T1-T2) for the complex of the FimH adhesin carbohydrate-binding domain with heptyl-mannose · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts, T1 relaxation values, T2 relaxation values | unmapped |
| EV-BMRB-21033 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 7 Solution structure of Lewis x (Gal-beta1,4-[Fuc-alpha1,3]-GlcNAc-beta) attached to a protein · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-P08191-F1 AlphaFold DB | af_prediction | plddt: 93.12 pLDDT | in silico AlphaFold DB prediction AF-P08191-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-300 | unmapped |
| EV-SMASH-SMFS-000770 SMASH-BIO | force_spectroscopy | study_record | in vitro FimH-mannose noncovalent bonds survive minutes to hours under force. · FimH adhesin; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001060 SMASH-BIO | force_spectroscopy | study_record | in vitro Binding site plasticity regulation of the FimH catch-bond mechanism. · FimH adhesin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001423 SMASH-BIO | force_spectroscopy | study_record | in vitro Binding site plasticity regulation of the FimH catch-bond mechanism · FimH adhesin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002362 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8.5 Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen. · FimH adhesin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003180 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Mechanical architecture and folding of E. coli type 1 pilus domains. · FimH adhesin; afm smfs; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004534 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 5 Dynamic modulation of fimbrial extension and FimH-mannose binding force on live bacteria under pH changes: a molecular atomic force microscopy analysis. · FimH adhesin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005066 SMASH-BIO | force_spectroscopy | study_record | in vitro The shaft of the type 1 fimbriae regulates an external force to match the FimH catch bond. · FimH adhesin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005676 SMASH-BIO | force_spectroscopy | study_record | in vitro The bacterial fimbrial tip acts as a mechanical force sensor. · FimH adhesin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005908 SMASH-BIO | force_spectroscopy | study_record | in vitro Shear-stabilized rolling behavior of E. coli examined with simulations. · FimH adhesin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006272 SMASH-BIO | force_spectroscopy | study_record | in vitro Biophysics of catch bonds. · FimH adhesin; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006275 SMASH-BIO | force_spectroscopy | study_record | in vitro Catch bonds in adhesion. · FimH adhesin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006276 SMASH-BIO | force_spectroscopy | study_record | in vitro Catch-bond mechanism of force-enhanced adhesion: counterintuitive, elusive, but ... widespread? · FimH adhesin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006325 SMASH-BIO | force_spectroscopy | study_record | in vitro FimH forms catch bonds that are enhanced by mechanical force due to allosteric regulation. · FimH adhesin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006758 SMASH-BIO | force_spectroscopy | study_record | in vitro Catch-bond model derived from allostery explains force-activated bacterial adhesion. · FimH adhesin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006925 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 9 Uncoiling mechanics of Escherichia coli type I fimbriae are optimized for catch bonds. · FimH adhesin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
Conflicts
No conflicts found among comparable evidence.
102 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.