Heat shock protein HSP 90-alpha
UniProt P07900 · gene HSP90AA1 · Homo sapiens · 732 residues
474evidence items
0mapped to a state
0states
8techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | neutron | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | md | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||||
Unmapped evidence: 474 of 474 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 11 | 0 |
| MDDB | 2 | 0 |
| RCSB PDB | 450 | 0 |
| SMASH-BIO | 10 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-2BSM-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 6.5 · ligands BSM Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design · HEAT SHOCK PROTEIN HSP90-ALPHA (chains A) | unmapped |
| EV-PDB-2C2L-2 RCSB PDB | xray | resolution: 3.3 Å | in vitro · -173.15 °C · pH 7.5 · ligands NI, SO4 Crystal structure of the CHIP U-box E3 ubiquitin ligase · HSP90 (chains E,F,G,H) | unmapped |
| EV-PDB-2WI5-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands ZZ5 Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2WI4-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 6.5 · ligands ZZ4 Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · HEAT SHOCK PROTEIN, HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2WI3-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands MG, ZZ3 Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · HEAT SHOCK PROTEIN, HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2WI2-1 RCSB PDB | xray | resolution: 2.09 Å | in vitro · -173.15 °C · pH 6.5 · ligands DMS, ZZ3 Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A,B) | unmapped |
| EV-PDB-2WI1-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands MG, ZZ2 Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2VCJ-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · ligands 2EQ 4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2VCI-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands 2GJ 4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2UWD-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2GG, MG, SO4 Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2QG2-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 6.5 · ligands A91 HSP90 complexed with A917985 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-2QG0-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 6.5 · ligands A94 HSP90 complexed with A943037 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-2QFO-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -163.15 °C · pH 8.5 · ligands A13, A51 HSP90 complexed with A143571 and A516383 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-2QF6-1 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -163.15 °C · pH 6.5 · ligands A56 HSP90 complexed with A56322 · Heat shock protein HSP 90-alpha (chains A,B,C,D) | unmapped |
| EV-PDB-2K5B-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.4 Human CDC37-HSP90 docking model based on NMR · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-2JJC-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 6.8 · ligands DMS, LGA Hsp90 alpha ATPase domain with bound small molecule fragment · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2H55-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands DZ8 Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-DZ8 · Heat shock protein HSP 90-alpha 4 (chains A) | unmapped |
| EV-PDB-2FWZ-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands H71 Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-2FWY-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands H64 Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-2CCU-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2D9 HUMAN HSP90 WITH 4-CHLORO-6-(4-(4-(4-METHANESULPHONYL-BENZYL)- PIERAZIN-1-YL)-1H-PYRAZOL-3-YL)-BENZENE-1,3-DIOL · HEAT SHOCK PROTEIN HSP-90 ALPHA (chains A) | unmapped |
| EV-PDB-2CCT-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2E1 HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL- 2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE · HEAT SHOCK PROTEIN HSP-90 ALPHA (chains A) | unmapped |
| EV-PDB-2CCS-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 6.5 · ligands 4BH HUMAN HSP90 WITH 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-3-YL)- BENZENE-1,2-DIOL · HEAT SHOCK PROTEIN HSP-90 ALPHA (chains A) | unmapped |
| EV-PDB-2BZ5-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands AB4 Structure-based Discovery of a New Class of Hsp90 Inhibitors · HEAT SHOCK PROTEIN HSP90-ALPHA (chains A,B) | unmapped |
| EV-PDB-2BYI-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 5.5 · ligands 2DD 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone · HEAT SHOCK PROTEIN HSP90-ALPHA (chains A) | unmapped |
| EV-PDB-2BYH-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2D7 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone · HEAT SHOCK PROTEIN HSP90-ALPHA (chains A) | unmapped |
| EV-PDB-2BUG-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6 Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide · HSP90 (chains B) | unmapped |
| EV-PDB-2BT0-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands CT5 Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design · HEAT SHOCK PROTEIN HSP90-ALPHA (chains A,B) | unmapped |
| EV-PDB-21FE-1 RCSB PDB | neutron | resolution: 2.1 Å | in vitro · 24.85 °C · pH 7.5 · ligands ADP, MG Neutron crystal structure of the ADP bound form of the human Hsp90 N-terminal domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-21FD-1 RCSB PDB | neutron | resolution: 2.1 Å | in vitro · 24.85 °C · pH 8.5 Neutron crystal structure of the apo form of the human Hsp90 N-terminal domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-1YET-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · ligands GDM GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN · HEAT SHOCK PROTEIN 90 (chains A) | unmapped |
| EV-PDB-1YES-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "OPEN" CONFORMATION · HEAT SHOCK PROTEIN 90 (chains A) | unmapped |
| EV-PDB-1YER-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "CLOSED" CONFORMATION · HEAT SHOCK PROTEIN 90 (chains A) | unmapped |
| EV-PDB-1YC4-1 RCSB PDB | xray | resolution: 1.81 Å | in vitro · -163.15 °C · pH 9 · ligands 43P Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-1YC3-1 RCSB PDB | xray | resolution: 2.12 Å | in vitro · -173.15 °C · pH 9 · ligands 4BC Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-1YC1-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -168.15 °C · pH 9 · ligands 4BC Crystal Structures of human HSP90alpha complexed with dihydroxyphenylpyrazoles · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-1UYL-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 6.5 Structure-Activity Relationships in purine-based inhibitor binding to HSP90 isoforms · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYK-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PUX Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-2-fluoro-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYI-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PUZ Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9-pent-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYH-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU0 Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYG-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU2 Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYF-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU1 Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-2-fluoro-9-pent-4-ylnyl-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYE-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU9 Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-9-pent-4-ylnyl-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYD-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU8 Human Hsp90-alpha with 9-Butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UYC-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU7 Human Hsp90-alpha with 9-Butyl-8-(2,5-dimethoxy-benzyl)-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UY9-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU6 Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UY8-1 RCSB PDB | xray | resolution: 1.98 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU5 Human Hsp90-alpha with 9-Butyl-8-(3-trimethoxy-benzyl)-9H-purin-6ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UY7-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU4 Human Hsp90-alpha with 9-Butyl-8-(4-methoxy-benzyl)-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1UY6-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands PU3 Human Hsp90-alpha with 9-Butyl-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-1OSF-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -168.15 °C · ligands ACY, KOS, MPD Human Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin · heat shock 90kDa protein 1, alpha; heat shock 90kD protein 1, alpha (chains A) | unmapped |
| EV-PDB-1BYQ-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -165.15 °C · pH 8.5 · ligands ADP, MG HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG · PROTEIN (HEAT SHOCK PROTEIN 90) (chains A) | unmapped |
| EV-PDB-2WI6-1 RCSB PDB | xray | resolution: 2.18 Å | in vitro · -173.15 °C · pH 6.5 · ligands ZZ6 Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · HEAT SHOCK PROTEIN, HSP90-ALPHA (chains A) | unmapped |
| EV-PDB-2WI7-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2KL Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XAB-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands VHD Structure of HSP90 with an inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA, (chains A,B) | unmapped |
| EV-PDB-2XDK-1 RCSB PDB | xray | resolution: 1.97 Å | in vitro · -173.15 °C · ligands XDK Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XDL-1 RCSB PDB | xray | resolution: 1.98 Å | in vitro · -173.15 °C · ligands 2DL Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XDS-1 RCSB PDB | xray | resolution: 1.97 Å | in vitro · -173.15 °C · ligands DMS, MT0 Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XDU-1 RCSB PDB | xray | resolution: 1.74 Å | in vitro · -173.15 °C · ligands DMS, LGA, MG, MT0 Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XDX-1 RCSB PDB | xray | resolution: 2.42 Å | in vitro · -173.15 °C · ligands WOE Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XHR-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands C0P Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XHT-1 RCSB PDB | xray | resolution: 2.27 Å | in vitro · -173.15 °C · ligands C0Y Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XHX-1 RCSB PDB | xray | resolution: 2.801 Å | in vitro · -173.15 °C · ligands T5M Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XJG-1 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · ligands XJG Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XJJ-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands GOL, L81 Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A,B) | unmapped |
| EV-PDB-2XJX-1 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · ligands XJX Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2XK2-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · ligands ADP, MG Structure of HSP90 with small molecule inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE2-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands SO4, XQI HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE3-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 6.5 · ligands VXX HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE4-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2FY HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE5-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2A7 HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE6-1 RCSB PDB | xray | resolution: 2.56 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2AE HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE7-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2GA HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE8-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2D3, MG HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YE9-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2D4 HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEA-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2A9 HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEB-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2K4, CL HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEC-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands SO4, XQ0 HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YED-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands ADE, CL HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEE-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2EC, SO4 HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEF-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 6.5 · ligands ANP, MG HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEG-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 6.5 · ligands XQG HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A,B) | unmapped |
| EV-PDB-2YEH-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2KU, SO4 HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEI-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands XQI, XQK HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YEJ-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands MG, XQK, ZZ3 HSP90 inhibitors and drugs from fragment and virtual screening · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YI0-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7 · ligands MG, YI0 Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YI5-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7 · ligands YI5 Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YI6-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7 · ligands 6QM, MG Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YI7-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 7 · ligands BZ8, MG Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YJW-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -173.15 °C · pH 7.5 · ligands YJW Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YJX-1 RCSB PDB | xray | resolution: 1.83 Å | in vitro · -173.15 °C · pH 7.5 · ligands YJX Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YK2-1 RCSB PDB | xray | resolution: 1.74 Å | in vitro · -173.15 °C · pH 7.5 · ligands YJW, YJX Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YK9-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · pH 7.5 · ligands YK9 Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YKB-1 RCSB PDB | xray | resolution: 1.93 Å | in vitro · -173.15 °C · pH 7.5 · ligands YKB Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YKC-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · pH 7.5 · ligands YKC Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YKE-1 RCSB PDB | xray | resolution: 1.43 Å | in vitro · -173.15 °C · pH 7.5 · ligands YKE Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YKI-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · pH 7.5 · ligands YKI Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-2YKJ-1 RCSB PDB | xray | resolution: 1.46 Å | in vitro · -173.15 °C · pH 7.5 · ligands YKJ Tricyclic series of Hsp90 inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-3B24-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 · ligands B2J, MG Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3B25-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8 · ligands B2K Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3B26-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 8 · ligands B2L Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3B27-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8 · ligands B2T Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3B28-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 6.5 · ligands B2X, GOL, MG Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3BM9-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -180.15 °C · pH 7.5 · ligands BXZ Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3EKR-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 4.4 · ligands PO4, PY9 Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3FT8-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands MOJ Structure of HSP90 bound with a noval fragment. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3HEK-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -175.15 °C · pH 4.4 · ligands BD0, PO4 HSP90 N-terminal domain in complex with 1-{4-[(2R)-1-(5-chloro-2,4-dihydroxybenzoyl)pyrrolidin-2-yl]benzyl}-3,3-difluoropyrrolidinium · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3HHU-1 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -171.75 °C · pH 8.5 · ligands 819 Human heat-shock protein 90 (HSP90) in complex with {4-[3-(2,4-dihydroxy-5-isopropyl-phenyl)-5-thioxo- 1,5-dihydro-[1,2,4]triazol-4-yl]-benzyl}-carbamic acid ethyl ester {ZK 2819} · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3HYZ-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 42C Crystal structure of Hsp90 with fragment 42-C03 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3HZ1-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 37D, 42C Crystal structure of Hsp90 with fragments 37-D04 and 42-C03 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3HZ5-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands Z64 Crystal structure of Hsp90 with fragment Z064 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3INX-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · ligands DMS, JZC HSP90 N-TERMINAL DOMAIN with pochoxime B · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3K97-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -175.15 °C · ligands 4CD, DMS HSP90 N-terminal domain in complex with 4-chloro-6-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3K98-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -175.15 °C · pH 4.2 · ligands 1RC, PO4 HSP90 N-terminal domain in complex with (1R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3K99-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -175.15 °C · pH 4.2 · ligands PFT HSP90 N-terminal domain in complex with 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol · Heat shock protein HSP 90-alpha (chains A,B,C,D) | unmapped |
| EV-PDB-3MNR-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -159.65 °C · pH 6.5 · ligands SD1 Crystal Structure of Benzamide SNX-1321 bound to Hsp90 · Heat shock protein HSP 90-alpha (chains P) | unmapped |
| EV-PDB-3O0I-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · pH 6.5 · ligands P54 Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor PU-H54 · HSP90AA1 protein (chains A) | unmapped |
| EV-PDB-3OW6-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 6.5 · ligands MEX Crystal Structure of HSP90 with N-Aryl-benzimidazolone I · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3OWB-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -163.15 °C · pH 6.5 · ligands BSM Crystal Structure of HSP90 with VER-49009 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3OWD-1 RCSB PDB | xray | resolution: 1.63 Å | in vitro · -163.15 °C · pH 6.5 · ligands MEY Crystal Structure of HSP90 with N-Aryl-benzimidazolone II · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3Q6N-1 RCSB PDB | xray | resolution: 3.05 Å | in vitro · -173.15 °C · ligands SO4 Crystal Structure of Human MC-HSP90 in P21 space group · Heat shock protein HSP 90-alpha (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-3QDD-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 6.5 · ligands 94M HSP90A N-terminal domain in complex with BIIB021 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3QTF-1 RCSB PDB | xray | resolution: 1.5703 Å | in vitro · -180.15 °C · pH 7.5 · ligands 05S, DMS Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3R4M-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -175.15 °C · pH 5.2 · ligands WOE Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3R4N-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -175.15 °C · pH 4.5 · ligands FU5 Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3R4O-1 RCSB PDB | xray | resolution: 2.65 Å | in vitro · -175.15 °C · pH 4.5 · ligands FU3 Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3R4P-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -175.15 °C · pH 4.3 · ligands FU7, PO4 Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3R92-1 RCSB PDB | xray | resolution: 1.5801 Å | in vitro · -180.15 °C · pH 6.5 · ligands 06J Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3RLP-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -175.15 °C · pH 4.3 · ligands 3RP, PO4 Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3RLQ-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -175.15 °C · pH 4.3 · ligands 3RQ, PO4 Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3RLR-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -155.15 °C · pH 4.3 · ligands 3RR, PO4 Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3T0Z-1 RCSB PDB | xray | resolution: 2.192 Å | in vitro · -73.15 °C · pH 6.5 · ligands ATP, MG Hsp90 N-terminal domain bound to ATP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3T10-1 RCSB PDB | xray | resolution: 1.24 Å | in vitro · -73.15 °C · pH 6.5 · ligands ACP, MG HSP90 N-terminal domain bound to ACP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3T1K-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -73.15 °C · ligands ANP, MG HSP90 N-terminal domain bound to ANP · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3T2S-1 RCSB PDB | xray | resolution: 1.501 Å | in vitro · -73.15 °C · pH 8.5 · ligands AGS, MG HSP90 N-terminal domain bound to AGS · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3TUH-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · ligands TUH Crystal Structure of the N-terminal domain of an HSP90 in the presence of an the inhibitor ganetespib · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3VHA-1 RCSB PDB | xray | resolution: 1.39 Å | in vitro · -173.15 °C · pH 6 · ligands MES, VHA Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3VHC-1 RCSB PDB | xray | resolution: 1.41 Å | in vitro · -173.15 °C · pH 8.5 · ligands MG, VHC Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3VHD-1 RCSB PDB | xray | resolution: 1.52 Å | in vitro · -173.15 °C · pH 6.5 · ligands VHE Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3WHA-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands GOL, MG, WHA Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-4AIF-2 RCSB PDB | xray | resolution: 2.006 Å | in vitro · -173.15 °C · ligands SO4 AIP TPR domain in complex with human Hsp90 peptide · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains D,E) | unmapped |
| EV-PDB-3WQ9-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -168.15 °C · pH 7.5 · ligands YUK Crystal structure of Hsp90-alpha N-terminal domain in complex with 2-(4-Hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3T0H-1 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -73.15 °C · pH 6.5 Structure insights into mechanisms of ATP hydrolysis and the activation of human Hsp90 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3RKZ-1 RCSB PDB | xray | resolution: 1.5693 Å | in vitro · -180.15 °C · pH 7.5 · ligands 06T Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3R91-1 RCSB PDB | xray | resolution: 1.579 Å | in vitro · -180.15 °C · pH 7.5 · ligands 06H Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3Q6M-1 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C · ligands SO4 Crystal Structure of Human MC-HSP90 in C2221 Space Group · Heat shock protein HSP 90-alpha (chains A,B,C) | unmapped |
| EV-PDB-3INW-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · ligands DMS, JZB HSP90 N-TERMINAL DOMAIN with pochoxime A · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3HYY-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands 37D Crystal structure of Hsp90 with fragment 37-D04 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3FT5-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands MO8 Structure of HSP90 bound with a novel fragment · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3EKO-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 4.4 · ligands PO4, PYU Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-3D0B-1 RCSB PDB | xray | resolution: 1.74 Å | in vitro · -160 °C · pH 6.5 · ligands SNX Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-3BMY-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -180.15 °C · pH 7.5 · ligands CXZ Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4BQG-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 50Q structure of HSP90 with an inhibitor bound · HSP90AA1 PROTEIN (chains A) | unmapped |
| EV-PDB-4L8Z-1 RCSB PDB | xray | resolution: 1.703 Å | in vitro · -173.15 °C · pH 6.5 · ligands RL1 Crystal structure of Human Hsp90 with RL1 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4XIP-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.5 · ligands 40W Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4W7T-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.5 · ligands 3JC Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4U93-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 6.5 · ligands 990 Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4R3M-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands JR9 Crystal structure of Human Hsp90 with JR9 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4O0B-1 RCSB PDB | xray | resolution: 1.93 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2QA Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4O09-1 RCSB PDB | xray | resolution: 1.96 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2R6 Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4O07-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · -173.15 °C · pH 6.5 · ligands FGH Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4O05-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2Q9 Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4O04-1 RCSB PDB | xray | resolution: 1.82 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2Q8 Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4NH8-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2LC Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4NH7-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands E0G, GOL Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-4LWI-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands FJ6 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4LWH-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.5 · ligands FJ5 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4LWG-1 RCSB PDB | xray | resolution: 1.599 Å | in vitro · -173.15 °C · pH 6.5 · ligands FJ4 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4LWF-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 6.5 · ligands FJ3 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4LWE-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 6.5 · ligands FJ2 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4L94-1 RCSB PDB | xray | resolution: 1.649 Å | in vitro · -173.15 °C · pH 6.5 · ligands S46 Crystal structure of Human Hsp90 with S46 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4L93-1 RCSB PDB | xray | resolution: 1.845 Å | in vitro · -173.15 °C · pH 6.5 · ligands S36 Crystal structure of Human Hsp90 with S36 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-4L91-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 6.5 · ligands X29 Crystal structure of Human Hsp90 with X29 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4L90-1 RCSB PDB | xray | resolution: 2.001 Å | in vitro · -173.15 °C · ligands RL3 Crystal structure of Human Hsp90 with RL3 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4JQL-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · pH 8.5 · ligands MG, VJ6 Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4HY6-1 RCSB PDB | xray | resolution: 1.649 Å | in vitro · -173.15 °C · ligands FJ1 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4FCR-1 RCSB PDB | xray | resolution: 1.698 Å | in vitro · -173.15 °C · pH 6.5 · ligands 0TM Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4FCQ-1 RCSB PDB | xray | resolution: 2.151 Å | in vitro · -173.15 °C · pH 6.5 · ligands 2N6 Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4FCP-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands 42C Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-4EGK-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · pH 7.2 · ligands RDC Human Hsp90-alpha ATPase domain bound to Radicicol · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4EGI-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 7.2 · ligands B2J Hsp90-alpha ATPase domain in complex with 2-Amino-4-ethylthio-6-methyl-1,3,5-triazine · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4EGH-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.2 · ligands 0OY, MG Hsp90-alpha ATPase domain in complex with (4-Hydroxyphenyl)morpholin-4-yl methanone · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4EFU-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands EFU, SO4 Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid benzyl-methyl-amide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4EFT-1 RCSB PDB | xray | resolution: 2.12 Å | in vitro · -173.15 °C · pH 6.5 · ligands EFT Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4EEH-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6.5 · ligands HH6, SO4 Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-(4-Hydroxy-phenyl)-1H-indazol-6-ol · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4CWT-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands IK9 Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CWS-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · ligands G3R Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CWR-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands HAJ Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CWQ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands W2D Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CWP-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · ligands TV2 Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CWO-1 RCSB PDB | xray | resolution: 2.31 Å | in vitro · -173.15 °C · ligands T62 Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CWN-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands 6LV Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CWF-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands H05 Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4CGW-2 RCSB PDB | xray | resolution: 3.001 Å | in vitro · -173.15 °C · pH 7 Second TPR of Spaghetti (RPAP3) bound to HSP90 peptide SRMEEVD · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains C,D) | unmapped |
| EV-PDB-4CGV-2 RCSB PDB | xray | resolution: 2.54 Å | in vitro · -173.15 °C · pH 7 · ligands GOL First TPR of Spaghetti (RPAP3) bound to HSP90 peptide SRMEEVD · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains E,F) | unmapped |
| EV-PDB-4CGU-3 RCSB PDB | xray | resolution: 2.11 Å | in vitro · -173.15 °C · pH 7 · ligands GOL Full length Tah1 bound to yeast PIH1 and HSP90 peptide SRMEEVD · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains C) | unmapped |
| EV-PDB-4CGQ-2 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7 · ligands CL Full length Tah1 bound to HSP90 peptide SRMEEVD · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains Q) | unmapped |
| EV-PDB-4BQJ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands XKL structure of HSP90 with an inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4B7P-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands 9UN Structure of HSP90 with NMS-E973 inhibitor bound · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A) | unmapped |
| EV-PDB-4AWQ-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -179.95 °C · pH 8 · ligands 592 Complex of HSP90 ATPase domain with tropane derived inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A,B) | unmapped |
| EV-PDB-4AWP-1 RCSB PDB | xray | resolution: 1.82 Å | in vitro · -179.95 °C · pH 8 · ligands 99A Complex of HSP90 ATPase domain with tropane derived inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A,B) | unmapped |
| EV-PDB-4AWO-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -179.95 °C · pH 8 · ligands 99B Complex of HSP90 ATPase domain with tropane derived inhibitors · HEAT SHOCK PROTEIN HSP 90-ALPHA (chains A,B) | unmapped |
| EV-PDB-4XIQ-1 RCSB PDB | xray | resolution: 1.84 Å | in vitro · -173.15 °C · pH 6.5 · ligands 40Y, GOL Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4XIR-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.5 · ligands 40X, GOL Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4XIT-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · -173.15 °C · ligands 40Z, GOL Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4YKW-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 7 · ligands 4ES Heat Shock Protein 90 Bound to CS312 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-4YKY-1 RCSB PDB | xray | resolution: 1.78 Å | in vitro · -173.15 °C · pH 8 · ligands 4EU, GOL Heat Shock Protein 90 Bound to CS319 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5CF0-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands FJS Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5FND-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands IQ5, SO4 Dynamic Undocking and the Quasi-Bound State as tools for Drug Design · HEAT SHOCK PROTEIN, HSP90-ALPHA (chains A) | unmapped |
| EV-PDB-5FNF-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands SO4, TQL Dynamic Undocking and the Quasi-Bound State as tools for Drug Design · HEAT SHOCK PROTEIN, HSP90-ALPHA (chains A) | unmapped |
| EV-PDB-5GGZ-1 RCSB PDB | xray | resolution: 2.015 Å | in vitro · -173.15 °C · pH 8.5 · ligands 6TN Crystal structure of novel inhibitor bound with Hsp90 · Heat shock protein HSP 90-alpha (chains A,B,C,D) | unmapped |
| EV-PDB-5J27-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -73.15 °C · pH 8.5 · ligands 6FF HSP90 in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-N-propyl-benzenesulfonamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J2V-1 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -73.15 °C Crystal Structure of Hsp90-alpha Apo N-domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J2X-1 RCSB PDB | xray | resolution: 1.22 Å | in vitro · -73.15 °C · ligands 6DL Crystal Structure of Hsp90-alpha N-domain in complex with 5-(5-Bromo-2,4-dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J64-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · pH 8.5 · ligands 6G7 Crystal Structure of Hsp90-alpha N-domain in complex with 5-(2,4-Dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J6L-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · ligands 6GC Crystal Structure of Hsp90-alpha N-domain in complex with N-Butyl-5-[4-(2-fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-benzamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J6M-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · ligands 6FJ Crystal Structure of Hsp90-alpha N-domain L107 mutant in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-N-furan-2-ylmethyl-2,4-dihydroxy-N-methyl-benzamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J6N-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 6FF Crystal Structure of Hsp90-alpha N-domain L107A mutant in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-N-propyl-benzenesulfonamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J80-1 RCSB PDB | xray | resolution: 1.17 Å | in vitro · -173.15 °C Crystal Structure of Apo Hsp90-alpha N-domain L107A mutant · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J82-1 RCSB PDB | xray | resolution: 2.17 Å | in vitro · -173.15 °C · ligands 6GV Crystal Structure of Hsp90-alpha N-domain in complex 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-isopropyl-N-methyl-benzenesulfonamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J86-1 RCSB PDB | xray | resolution: 1.87 Å | in vitro · -173.15 °C · ligands 6GW Crystal Structure of Hsp90-alpha N-domain in complex with 2,4-Dihydroxy-N-methyl-5-(5-oxo-4-o-tolyl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)-N-thiophen-2-ylmethyl-benzamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J8M-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 6DL Crystal Structure of Hsp90-alpha N-domain L107A mutant in complex with 5-(5-Bromo-2,4-dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-5J8U-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · ligands 6DL Crystal Structure of Hsp90-alpha N-domain L107A mutant in complex with 5-(2,4-Dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-5J9X-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands 6GC, DMS HSP90 in complex with N-Butyl-5-[4-(2-fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-2,4-dihydroxy-N-methyl-benzamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LNY-1 RCSB PDB | xray | resolution: 1.88 Å | in vitro · -173.15 °C · pH 8.5 · ligands 70K HSP90 WITH indazole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LO0-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 70N HSP90 WITH indazole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LO1-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 6.5 · ligands 70L HSP90 WITH indazole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LO6-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 6.5 · ligands 70O HSP90 WITH indazole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LQ9-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands 72K CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR200323. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LR1-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · ligands 72Y CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LR7-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · -173.15 °C · ligands 73J CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR567530 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LRL-1 RCSB PDB | xray | resolution: 1.33 Å | in vitro · -173.15 °C · ligands 73S CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003492875 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LS1-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · ligands 73Z CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5M4E-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands 7F9, SO4 Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5M4H-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands 7FX, SO4 Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5NYH-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · ligands 9EK Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5NYI-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · pH 8.5 · ligands 2EQ Crystal Structure of Hsp90-alpha N-Domain in complex with Resorcinol derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5OCI-1 RCSB PDB | xray | resolution: 1.62 Å | in vitro · -173.15 °C · ligands 9R8 Human Heat Shock Protein 90 bound to 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5ODX-1 RCSB PDB | xray | resolution: 1.82 Å | in vitro · -173.15 °C · ligands 9RZ, DMS Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5T21-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands 74E CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5OD7-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands H0T Hsp90 inhibitor desolvation as a rationale to steer on-rates and impact residence time · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LRZ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands 73Y CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003643501 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LO5-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · pH 5.5 · ligands 70M HSP90 WITH indole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5LNZ-1 RCSB PDB | xray | resolution: 1.54 Å | in vitro · -173.15 °C · pH 7.5 · ligands 70Z HSP90 WITH indazole derivative · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5J20-1 RCSB PDB | xray | resolution: 1.76 Å | in vitro · -173.15 °C · pH 8.5 · ligands 6FJ HSP90 in complex with 5-[4-(2-Fluoro-phenyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-N-furan-2-ylmethyl-2,4-dihydroxy-N-methyl-benzamide · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5FNC-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands IEE, SO4 Dynamic Undocking and the Quasi-Bound State as tools for Drug Design · HEAT SHOCK PROTEIN, HSP90-ALPHA (chains A) | unmapped |
| EV-PDB-4YKZ-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 8 · ligands 4EV Heat Shock Protein 90 Bound to CS320 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4YKX-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands 4ET, GOL Heat Shock Protein 90 Bound to CS318 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4YKU-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 · ligands 4ER Heat Shock Protein 90 Bound to CS311 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4YKT-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 8 · ligands 4EQ Heat Shock Protein 90 Bound to CS307 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4YKR-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -173.15 °C · pH 8 · ligands 4EP, GOL Heat Shock Protein 90 Bound to CS302 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-4YKQ-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 8 · ligands 4EO Heat Shock Protein 90 Bound to CS301 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5ZR3-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -168.15 °C · pH 7.5 · ligands 9J0 Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide · Heat shock protein HSP 90-alpha (chains A,C,E,G) | unmapped |
| EV-PDB-6LTI-1 RCSB PDB | xray | resolution: 1.588 Å | in vitro · -173.15 °C · ligands 2GJ, MG HSP90 in complex with NVP-AUY922 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6LT8-1 RCSB PDB | xray | resolution: 1.593 Å | in vitro · -173.15 °C · ligands ET3 HSP90 in complex with KW-2478 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6LSZ-1 RCSB PDB | xray | resolution: 1.992 Å | in vitro · -173.15 °C · ligands TUH HSP 90 in complex with Ganetespib · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6LR9-1 RCSB PDB | xray | resolution: 2.196 Å | in vitro · -173.15 °C · ligands EOR, GOL HSP90 in complex with Debio0932 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6KSQ-1 RCSB PDB | xray | resolution: 2.202 Å | in vitro · -173.15 °C · pH 8.5 Middle Domain of Human HSP90 Alpha · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6HHR-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands G5E, SO4 Hsp90 in complex with 5-(2,4-Dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazole-3-thione · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GR5-1 RCSB PDB | xray | resolution: 1.34 Å | in vitro · -173.15 °C · pH 6.5 · ligands ADP, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with ADP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GR4-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 6.5 · ligands CL, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GR3-1 RCSB PDB | xray | resolution: 1.88 Å | in vitro · -173.15 °C · ligands AN2, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with AMPPNP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GR1-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 6.5 · ligands APC, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with AMPCPP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GQU-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · pH 6.5 · ligands CMP Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with cAMP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GQS-1 RCSB PDB | xray | resolution: 1.43 Å | in vitro · -173.15 °C · pH 6.5 · ligands A12, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with AMPCP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GQR-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 6.5 · ligands APC, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with AMPCPP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GQ6-1 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · pH 6.5 · ligands ADP, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with ADP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPY-1 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · pH 6.5 · ligands ANP, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with AMPPNP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPW-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6.5 · ligands CL, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPT-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.5 · ligands A12, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with AMPCP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPR-1 RCSB PDB | xray | resolution: 2.35 Å | in vitro · -173.15 °C · pH 6.5 · ligands CMP Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with cAMP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPP-1 RCSB PDB | xray | resolution: 1.51 Å | in vitro · -173.15 °C · pH 6.5 · ligands ADP, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with ADP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPO-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · pH 6.5 · ligands CMP, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with cAMP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPH-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · -173.15 °C · pH 6.5 · ligands A12, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with AMPCP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GPF-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 6.5 · ligands ANP, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with AMPPNP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GP8-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 6.5 · ligands APC, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex AMPCPP · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6GP4-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.5 · ligands CL, MG Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6FDP-2 RCSB PDB | nmr_structure | structure | in vitro · 19.85 °C · pH 6.4 NMR structure of the second TPR domain of the human RPAP3 protein in complex with HSP90 peptide DTSRMEEVD · Heat shock protein HSP 90-alpha (chains B) | unmapped |
| EV-PDB-6FCJ-1 RCSB PDB | xray | resolution: 2.49 Å | in vitro · -173.15 °C · ligands D4W Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6F1N-1 RCSB PDB | xray | resolution: 2.09 Å | in vitro · -173.15 °C · pH 6.5 · ligands C8W, SO4 Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6EYB-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands C3Z, SO4 Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6EYA-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands C4K Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6EY9-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands C4N, SO4 Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6EY8-1 RCSB PDB | xray | resolution: 2.16 Å | in vitro · -173.15 °C · pH 6.5 · ligands C4T, DMS, SO4 Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6ELP-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 6.5 · ligands BA8 Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6ELO-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.5 · ligands BAW Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6ELN-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6.5 · ligands P4A, SO4 Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6EL5-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · ligands PU1 Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6EI5-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands B5Q Estimation of relative drug-target residence times by random acceleration molecular dynamics simulation · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6CYH-1 RCSB PDB | xray | resolution: 1.49 Å | in vitro · -173.15 °C · pH 6.4 · ligands MG, N5A Hsp90-alpha N-domain bound to NEACA · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-6CYG-1 RCSB PDB | xray | resolution: 1.50392 Å | in vitro · -173.15 °C · pH 6.4 · ligands MG, N5O Hsp90-alpha N-domain bound to NEOCA · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-6CEO-1 RCSB PDB | xray | resolution: 1.896 Å | in vitro · -173.15 °C · ligands D57, EDO, MG Structure of Hsp90 NTD with a GRP94-selective resorcinylic inhibitor. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6B9A-1 RCSB PDB | xray | resolution: 1.65381 Å | in vitro · -173.15 °C · pH 6.4 · ligands PA7 Hsp90-alpha N-domain bound to NPCA · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-6B99-1 RCSB PDB | xray | resolution: 1.60238 Å | in vitro · -173.15 °C · pH 6.4 · ligands NEC Hsp90-alpha N-domain bound to NECA · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5XRE-1 RCSB PDB | xray | resolution: 1.497 Å | in vitro · -173.15 °C · pH 6.5 · ligands JX1 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5XRD-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands 9ZC Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5XRB-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · ligands 8DU Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5XR9-1 RCSB PDB | xray | resolution: 1.501 Å | in vitro · -173.15 °C · ligands 8CU Crystal structure of Human Hsp90 with FS6 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5XR5-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6.5 · ligands 8CR Crystal structure of Human Hsp90 with FS4 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5XQE-1 RCSB PDB | xray | resolution: 1.699 Å | in vitro · -173.15 °C · ligands 8CO Crystal structure of Human Hsp90 with FS3 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5XQD-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · ligands 8CF Crystal structure of Human Hsp90 with FS2 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-5VYY-1 RCSB PDB | xray | resolution: 1.792 Å | in vitro · -173.15 °C · pH 6.5 · ligands 9QY, EDO, FMT, MG, NA Structure of human Hsp90-alpha bound to resorcinylic inhibitor BnIm · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6OLX-1 RCSB PDB | xray | resolution: 1.43761 Å | in vitro · -173.15 °C · pH 6.5 · ligands KFY Hsp90-alpha S52A bound to PU-11-trans · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6TN4-1 RCSB PDB | xray | resolution: 1.274 Å | in vitro · -173.15 °C · pH 6.5 · ligands CL, NLZ Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures · Heat shock protein HSP 90-alpha (chains AAA) | unmapped |
| EV-PDB-6TN5-1 RCSB PDB | xray | resolution: 1.165 Å | in vitro · -173.15 °C · pH 6.5 · ligands CL, NL8 Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures · Heat shock protein HSP 90-alpha (chains AAA) | unmapped |
| EV-PDB-6U98-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands K, NA, Q2D Hsp90a NTD K58R bound reversibly to sulfonyl fluoride 6 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6U99-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · ligands Q2J Hsp90a NTD covalently bound to sulfonyl fluoride probe 1 at K58 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6U9A-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · ligands Q2A Hsp90a NTD K58R bound reversibly to sulfonyl fluoride 5 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6U9B-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · ligands Q2A Hsp90a NTD covalently bound to sulfonyl fluoride 5 at K58 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7DMC-1 RCSB PDB | xray | resolution: 2.34 Å | in vitro · -173.15 °C · ligands CL, H9F, MG Dipyridamole binds to the N-terminal domain of human Hsp90A · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9K-1 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW3 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12478 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9L-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW6 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14229 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9M-1 RCSB PDB | xray | resolution: 1.49 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW8 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13527 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9N-1 RCSB PDB | xray | resolution: 2.35 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXZ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13347 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9P-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · pH 8.5 · ligands HX8 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12541 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9R-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX2 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14452 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9S-1 RCSB PDB | xray | resolution: 2.17 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXJ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with FS-3027 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9U-1 RCSB PDB | xray | resolution: 1.94 Å | in vitro · -173.15 °C · pH 8.5 · ligands 8K2 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12864 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9V-1 RCSB PDB | xray | resolution: 1.52 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXO PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12319 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9W-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · pH 8.5 · ligands SLS PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12314 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9X-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXD PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14128 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9Y-1 RCSB PDB | xray | resolution: 2.11 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXF PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with NH-0224 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9Z-1 RCSB PDB | xray | resolution: 2.06 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXH PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12500 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA0-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · pH 8.5 · ligands 54F PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12546 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA1-1 RCSB PDB | xray | resolution: 1.46 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX6 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with FL0092 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA2-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX8 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14256 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA3-1 RCSB PDB | xray | resolution: 1.98 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW0 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14259 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA4-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW1 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14240 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA5-1 RCSB PDB | xray | resolution: 1.53 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW2 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-3550 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA6-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW5 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with DH-0718 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA7-1 RCSB PDB | xray | resolution: 2.27 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW7 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-5947 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA8-1 RCSB PDB | xray | resolution: 2.22 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXY PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14439 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HA9-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW9 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13551 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAA-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXB PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13279 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAB-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXC PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12700 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAC-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX1 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13324 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAD-1 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX3 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14363 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAE-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXK PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13215 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAF-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXM PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13854 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAG-1 RCSB PDB | xray | resolution: 1.53 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXN PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14186 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAH-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXP PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-5160 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAI-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXQ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-5525 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAJ-1 RCSB PDB | xray | resolution: 1.57 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXE PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-4122 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAK-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXG PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-6793 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAL-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX4 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12580 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAM-1 RCSB PDB | xray | resolution: 1.77 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX5 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14242 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAN-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX7 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-3286 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9T-1 RCSB PDB | xray | resolution: 2.48 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXL PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12599 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9Q-1 RCSB PDB | xray | resolution: 1.51 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX0 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13944 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7H9O-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXA PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13146 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6N8X-1 RCSB PDB | xray | resolution: 1.49484 Å | in vitro · -173.15 °C · pH 6.5 · ligands KFY Hsp90-alpha bound to PU-11-trans · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-6LTK-1 RCSB PDB | xray | resolution: 2.141 Å | in vitro · -173.15 °C · ligands E0G HSP90 in complex with SNX-2112 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAR-1 RCSB PDB | xray | resolution: 1.77 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYW PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12616 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBR-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXW PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with AS-5576 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBX-1 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY7 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with AS-5591 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HC2-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AW4 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 2X-5009 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HC1-1 RCSB PDB | xray | resolution: 2.13 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYS PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 10T-0263 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HC0-1 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYR PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 4W-0801 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBZ-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYQ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 6R-0009 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBY-1 RCSB PDB | xray | resolution: 1.82 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYP PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 9R-0342 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBW-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY3 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-4774 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBV-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXT PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-4833 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBU-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · pH 8.5 · ligands KXQ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with CC-0741 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBT-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXR PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with PS-3621 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBS-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXX PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 10X-0806 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBQ-1 RCSB PDB | xray | resolution: 2.73 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXU PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with FS-2731 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBP-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYL PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13188 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBO-1 RCSB PDB | xray | resolution: 2.07 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY1 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13368 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBN-1 RCSB PDB | xray | resolution: 1.99 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1ABL PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13145 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBM-1 RCSB PDB | xray | resolution: 2.21 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYJ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13278 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBL-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8.5 · ligands 9TW PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12214 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBK-1 RCSB PDB | xray | resolution: 2.14 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYG PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13232 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBJ-1 RCSB PDB | xray | resolution: 2.65 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYE PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13498 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBH-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYC PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13518 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBG-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYB PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13237 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBF-1 RCSB PDB | xray | resolution: 1.97 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY6 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12938 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBE-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYZ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12771 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBD-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYX PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12810 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBC-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYV PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13229 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBB-1 RCSB PDB | xray | resolution: 1.84 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY4 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13430 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HBA-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYO PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13425 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB9-1 RCSB PDB | xray | resolution: 1.89 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYN PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13464 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB8-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXS PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13480 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB7-1 RCSB PDB | xray | resolution: 2.98 Å | in vitro · -173.15 °C · pH 8.5 · ligands WP1 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12696 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB6-1 RCSB PDB | xray | resolution: 2.09 Å | in vitro · -173.15 °C · pH 8.5 · ligands 72R PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13755 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB5-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands 6RO PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13078 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB4-1 RCSB PDB | xray | resolution: 1.87 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AXV PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14472 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB3-1 RCSB PDB | xray | resolution: 2.34 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYM PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13043 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB2-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY2 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with FL0184 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB1-1 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · pH 8.5 · ligands A7Q PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12936 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HB0-1 RCSB PDB | xray | resolution: 1.78 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYK PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12780 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAZ-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYI PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12919 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAY-1 RCSB PDB | xray | resolution: 2.27 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYH PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr14271 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAX-1 RCSB PDB | xray | resolution: 2.29 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYF PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13909 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAW-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYD PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12961 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAV-1 RCSB PDB | xray | resolution: 2.45 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY0 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12879 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAU-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYA PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13098 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAT-1 RCSB PDB | xray | resolution: 2.04 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AY5 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12860 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAS-1 RCSB PDB | xray | resolution: 2.08 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYY PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr12355 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAQ-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYU PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13428 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAP-1 RCSB PDB | xray | resolution: 2.35 Å | in vitro · -173.15 °C · pH 8.5 · ligands FMQ PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13088 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HAO-1 RCSB PDB | xray | resolution: 1.83 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AX9 PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with Fr13777 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7HC3-1 RCSB PDB | xray | resolution: 2.22 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1AYT PanDDA analysis group deposition -- Crystal structure of HSP90N in complex with 3T-0629 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7L7J-2 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands ANP Cryo-EM structure of Hsp90:p23 closed-state complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-7S9I-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · 4.85 °C · ligands 7PP Room-temperature Human Hsp90a-NTD bound to EC144 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9YR4-2 RCSB PDB | cryoem | resolution: 3.64 Å | in vitro Cryo-EM structure of human Tom70 in complex with Hsp90 C-terminal EEVD peptide · Heat shock protein HSP 90-alpha (chains B) | unmapped |
| EV-PDB-9XZ1-1 RCSB PDB | xray | resolution: 1.96 Å | in vitro · -173.15 °C · pH 6.5 · ligands A1CRY, BTB, CA, GDP, MG KRAS(G12C)-RNK07311-HSP90(N-terminus) · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9XJ8-1 RCSB PDB | cryoem | resolution: 4.09 Å | in vitro · ligands ATP Cryo-EM structure of Hsp90(E47A)-FKBP8 complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-9X73-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Hsp90a T115E N-terminal domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9X72-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 closed-form Hsp90a T36E N-terminal domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9X71-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 the closed-form Hsp90a NTD · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9X70-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Hsp90a T36E N-terminal domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9X6X-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Hsp90a N-terminal domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9QQU-2 RCSB PDB | xray | resolution: 2.13 Å | in vitro · -173.15 °C · pH 5 · ligands SO4 Crystal structure of an engineered TPR domain in complex with the HSP90 peptide MEEVD · Heat shock protein HSP 90-alpha (chains B) | unmapped |
| EV-PDB-9KQN-1 RCSB PDB | cryoem | resolution: 2.84 Å | in vitro · ligands ADP Hsp90-Cdc37-PINK1 complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-9KOX-2 RCSB PDB | cryoem | resolution: 4.43 Å | in vitro · ligands ADP human Hsp90-FKBP51-PINK1 complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-9KMR-1 RCSB PDB | cryoem | resolution: 2.98 Å | in vitro · ligands ADP Human Hsp90-PINK1 complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-9IMW-1 RCSB PDB | xray | resolution: 1.527 Å | in vitro · -173.15 °C Crystal structure of N-terminal domain of human Hsp90 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-9AUU-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.2 · ligands A1AG2, MG Hsp90 NTD in complex with compound 6 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-8X2R-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · ligands EDO, GOL The Crystal Structure of HSP 90-alpha from Biortus. · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-8W8K-1 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · pH 8.5 · ligands MG, TUH Crystal structures of HSP90 and the compound Ganetespid in the "closed" conformation · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-8W4V-1 RCSB PDB | xray | resolution: 1.81 Å | in vitro · -173.15 °C · pH 7.1 · ligands MG, Q9O Crystal structure of human HSP90 in complex with compound 4 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-8SBT-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands MG, ZUY Structure of human Hsp90-alpha bound to purine inhibitor PU-H36 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-8KI4-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 8.5 · ligands EDO Crystal structure of human HSP90 in intermediate state · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-8JRA-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 N-terminal domain of Hsp90a mutant · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-8JR7-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 N-terminal domain of Hsp90 mutant · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-8JR6-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Hsp90a N-terminal domain · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-8FFW-1 RCSB PDB | cryoem | resolution: 3.23 Å | in vitro · ligands ATP, DEX, MG Cryo-EM structure of the GR-Hsp90-FKBP51 complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-8FFV-1 RCSB PDB | cryoem | resolution: 3.01 Å | in vitro · ligands ATP, DEX, MG Cryo-EM structure of the GR-Hsp90-FKBP52 complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-8B7J-1 RCSB PDB | nmr_structure | structure | in vitro · 14.85 °C · pH 7.5 Human HSP90 alpha ATP Binding Domain, ATP-lid closed conformation, R46A · HSP90AA1 protein (chains A) | unmapped |
| EV-PDB-8B7I-1 RCSB PDB | nmr_structure | structure | in vitro · 19.85 °C · pH 7.5 Human HSP90 alpha ATP Binding Domain, ATP-lid open conformation, R60A · HSP90AA1 protein (chains A) | unmapped |
| EV-PDB-8AGL-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 8.5 · ligands M0U Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with JMC31 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-8AGJ-1 RCSB PDB | xray | resolution: 2.32 Å | in vitro · -173.15 °C · pH 6.5 · ligands M0U Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with JMC31 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-8AGI-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 8.5 · ligands M0U Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with JMC31 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-7UR3-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · ligands OJ3 Hsp90 alpha inhibitor · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S9H-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · ligands 7PP, MG Cryogenic Human Hsp90a-NTD bound to EC144 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S9G-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · 4.85 °C · ligands 94M, MG Room-temperature Human Hsp90a-NTD bound to BIIB021 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S9F-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · ligands 94M, MG Cryogenic Human Hsp90a-NTD bound to BIIB021 · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S99-1 RCSB PDB | xray | resolution: 1.52 Å | in vitro · 4.85 °C · ligands N6M Room-temperature Human Hsp90a-NTD bound to N6M · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S98-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands N6M Cryogenic Human Hsp90a-NTD bound to N6M · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S95-1 RCSB PDB | xray | resolution: 1.71 Å | in vitro · 4.85 °C · ligands ADE Room-temperature Human Hsp90a-NTD bound to adenine · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S90-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · ligands ADE Cryogenic Human Hsp90a-NTD bound to adenine · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S8Z-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · 4.85 °C Room-temperature apo Human Hsp90a-NTD · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7S8Y-1 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C Cryogenic apo Human Hsp90a-NTD · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7RY1-1 RCSB PDB | xray | resolution: 3.523 Å | in vitro · -173.15 °C · ligands MDC human Hsp90_MC domain structure · Heat shock protein HSP 90-alpha (chains A,B,C) | unmapped |
| EV-PDB-7RY0-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands DMS, GOL human Hsp90_MC domain structure · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-7RXZ-1 RCSB PDB | xray | resolution: 3.152 Å | in vitro · -173.15 °C human Hsp90_MC domain structure · Heat shock protein HSP 90-alpha (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-7LT0-1 RCSB PDB | xray | resolution: 1.697 Å | in vitro · -173.15 °C · ligands ONJ Hsp90a N-terminal inhibitor · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7LSZ-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands ONG Hsp90a N-terminal inhibitor · Heat shock protein HSP 90-alpha (chains A) | unmapped |
| EV-PDB-7L7I-2 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ANP Cryo-EM structure of Hsp90:FKBP51:p23 closed-state complex · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-7KW7-1 RCSB PDB | cryoem | resolution: 3.57 Å | in vitro · ligands ADP, K, MG Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-PDB-7KRJ-1 RCSB PDB | cryoem | resolution: 2.56 Å | in vitro · ligands ATP, DEX, MG The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone p23 · Heat shock protein HSP 90-alpha (chains A,B) | unmapped |
| EV-BMRB-19560 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.2 N-terminal and Middle domains of human Hsp90alpha · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34223 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 6.4 NMR structure of the second TPR domain of the human RPAP3 protein in complex with HSP90 peptide DTSRMEEVD · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34758 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 7.5 Human HSP90 alpha ATP Binding Domain, ATP-lid open conformation, R60A · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34759 BMRB | nmr_shifts | chemical_shift | in vitro · 14.85 °C · pH 7.5 Human HSP90 alpha ATP Binding Domain, ATP-lid closed conformation, R46A · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36795 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Hsp90a N-terminal domain · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36796 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Hsp90a T36E N-terminal domain · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36797 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 the closed-form Hsp90a NTD · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36798 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 closed-form Hsp90a T36E N-terminal domain · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36799 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Hsp90a T115E N-terminal domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-50786 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.5 N-terminal domain of human HSP90 alpha1 form · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-7003 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.5 NMR backbone assignment of the human HSP90 N-terminal domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-P07900-F1 AlphaFold DB | af_prediction | plddt: 85.19 pLDDT | in silico AlphaFold DB prediction AF-P07900-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-732 | unmapped |
| EV-MDDB-A010M MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1YER · start 1YER; Amber Parm99 | unmapped |
| EV-MDDB-A0112 MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1YES · start 1YES; Amber Parm99 | unmapped |
| EV-SMASH-SMFS-000877 SMASH-BIO | force_spectroscopy | study_record | in vitro One-Pot Dual Protein Labelling for Simultaneous Mechanical and Fluorescent Readouts in Optical Tweezers · Hsp90 chaperone; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-001399 SMASH-BIO | force_spectroscopy | study_record | in vitro Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments. · Hsp90 chaperone; optical tweezers; experiment class: receptor_ligand_adhesion, translation_transcription_replication, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001481 SMASH-BIO | force_spectroscopy | study_record | in vitro Direct observation of Hsp90-induced compaction in a protein chain. · Hsp90 chaperone; optical tweezers; experiment class: nucleic_acid_protein_interaction, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001787 SMASH-BIO | force_spectroscopy | study_record | in vitro Using Single-Molecule Optical Tweezers to Study the Conformational Cycle of the Hsp90 Molecular Chaperone. · Hsp90 chaperone; optical tweezers; experiment class: translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001885 SMASH-BIO | force_spectroscopy | study_record | in vitro Direct observation of Hsp90-induced compaction in a protein chain · Hsp90 chaperone; optical tweezers; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, translation_transcription_replication, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003104 SMASH-BIO | force_spectroscopy | study_record | in vitro Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy. · Hsp90 chaperone; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003301 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor. · Hsp90 chaperone; optical tweezers; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003817 SMASH-BIO | force_spectroscopy | study_record | in vitro Alternative modes of client binding enable functional plasticity of Hsp70. · Hsp90 chaperone; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003900 SMASH-BIO | force_spectroscopy | study_record | in vitro Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments. · Hsp90 chaperone; optical tweezers; experiment class: translation_transcription_replication, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004751 SMASH-BIO | force_spectroscopy | study_record | in vitro UNC-45B chaperone: the role of its domains in the interaction with the myosin motor domain. · Hsp90 chaperone; afm smfs; experiment class: force_generation_motor, unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
474 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.