Beta-2 adrenergic receptor
UniProt P07550 · gene ADRB2 · Homo sapiens · 413 residues
157evidence items
18mapped to a state
2states
8techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | saxs_sans | cd | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| inactive (inverse agonist-bound) B2AR-inactive | observed | proc 11 | proc 1 | · | · | · | · | · | · | 12 |
| active (Gs-coupled) B2AR-active | observed | proc 2 | proc 4 | · | · | · | · | · | · | 6 |
Unmapped evidence: 139 of 157 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 1 | 0 |
| DisProt | 3 | 0 |
| RCSB PDB | 149 | 18 |
| SMASH-BIO | 3 | 0 |
Curated rules applied
b2ar-active-title: 4 itemsb2ar-inverse-agonist: 11 items
Structure
Choose a state. Each model is badged observed or inferred; assumptions are one click away.
States and transitions
| State | Basis | Parent | Description |
|---|---|---|---|
| inactive (inverse agonist-bound) B2AR-inactive | observed | — | Inactive receptor bound to the inverse agonist carazolol, as in 2RH1 (T4 lysozyme fusion). Family vocabulary gpcr: activation: inactive |
| active (Gs-coupled) B2AR-active | observed | — | Agonist-bound receptor in complex with Gs, as in 3SN6. Family vocabulary gpcr: activation: active |
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-2R4S-1 RCSB PDB | xray | resolution: 3.4 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the human beta2 adrenoceptor · Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-2RH1-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -195.15 °C · pH 6.75 · ligands 12P, ACM, BU1, CAU, CLR, PLM, SO4, branched: alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose High resolution crystal structure of human B2-adrenergic G protein-coupled receptor. · beta-2-adrenergic receptor/T4-lysozyme chimera (chains A) | inactive (inverse agonist-bound) · curator:draft (unreviewed) · high Carazolol (CAU) bound receptor-T4L fusion. |
| EV-PDB-3D4S-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -196.15 °C · pH 7 · ligands CLR, OLC, TIM Cholesterol bound form of human beta2 adrenergic receptor. · Beta-2 adrenergic receptor/T4-lysozyme chimera (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-3KJ6-1 RCSB PDB | xray | resolution: 3.4 Å | in vitro · -173.15 °C · pH 7 · ligands SO4 Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex · Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-3NY8-1 RCSB PDB | xray | resolution: 2.84 Å | in vitro · -173.15 °C · ligands CLR, JRZ, OLA, OLC, PGE Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551 · Beta-2 adrenergic receptor, Lysozyme (chains A) | unmapped |
| EV-PDB-3NY9-1 RCSB PDB | xray | resolution: 2.84 Å | in vitro · -173.15 °C · ligands CLR, JSZ, OLC Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist · Beta-2 adrenergic receptor, Lysozyme (chains A) | unmapped |
| EV-PDB-3NYA-1 RCSB PDB | xray | resolution: 3.16 Å | in vitro · -173.15 °C · ligands CLR, JTZ Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol · Beta-2 adrenergic receptor, Lysozyme (chains A) | unmapped |
| EV-PDB-3SN6-4 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -195.15 °C · pH 6.5 · ligands P0G Crystal structure of the beta2 adrenergic receptor-Gs protein complex · Endolysin,Beta-2 adrenergic receptor (chains R) | active (Gs-coupled) · curator:draft (unreviewed) · high Receptor-Gs complex. |
| EV-PDB-4GBR-1 RCSB PDB | xray | resolution: 3.993 Å | in vitro · -173.15 °C · pH 6.5 · ligands CAU N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor · Beta-2 adrenergic receptor (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-4LDE-1 RCSB PDB | xray | resolution: 2.79 Å | in vitro · -195.15 °C · pH 6.5 · ligands 1WV, NA, P0G Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody · Lysozyme, Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-4LDL-1 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -195.15 °C · pH 6.5 · ligands 1WV, NA, XQC Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody · Lysozyme, Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-4LDO-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -195.15 °C · pH 6.5 · ligands 1WV, ALE, NA Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody · Lysozyme, Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-4QKX-1 RCSB PDB | xray | resolution: 3.3 Å | in vitro · -195.15 °C · pH 7.8 · ligands 35V, NA Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody · Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-6KR8-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Structure of the beta2 adrenergic receptor in the full agonist bound state · beta 2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-7BZ2-5 RCSB PDB | cryoem | resolution: 3.82 Å | in vitro · ligands H98 Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. · Beta2 adrenergic receptor (chains R) | active (Gs-coupled) · rule:b2ar-active-title · medium Title describes a G protein complex or a nanobody-stabilised active state. |
| EV-PDB-8GE8-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#9 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE7-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#8 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE6-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#7 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE5-4 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#6 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE4-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#5 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE3-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#4 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE2-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#3 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE1-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#2 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GDZ-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#1 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-7XKA-1 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -193.15 °C · ligands G1I, NA Structure of human beta2 adrenergic receptor bound to constrained epinephrine · Endolysin,Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-7XK9-1 RCSB PDB | xray | resolution: 3.4 Å | in vitro · -193.15 °C · ligands GJ6, NA Structure of human beta2 adrenergic receptor bound to constrained isoproterenol · Endolysin,Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-7DHR-5 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands 5FW Cryo-EM structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-Gs protein complex. · Beta-2 adrenergic receptor (chains R) | active (Gs-coupled) · rule:b2ar-active-title · medium Title describes a G protein complex or a nanobody-stabilised active state. |
| EV-PDB-7DHI-5 RCSB PDB | cryoem | resolution: 3.26 Å | in vitro · ligands 68H Cryo-EM structure of the partial agonist salbutamol-bound beta2 adrenergic receptor-Gs protein complex. · Beta-2 adrenergic receptor (chains R) | active (Gs-coupled) · rule:b2ar-active-title · medium Title describes a G protein complex or a nanobody-stabilised active state. |
| EV-PDB-6PS6-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · 19.85 °C · ligands CLR, OLA, OLC, SO4, TIM XFEL beta2 AR structure by ligand exchange from Timolol to Timolol. · Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-6PS5-1 RCSB PDB | xray | resolution: 2.9 Å | in vitro · 19.85 °C · ligands CLR, OLA, OLC, SNP, SO4 XFEL beta2 AR structure by ligand exchange from Timolol to Propranolol. · Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A) | unmapped |
| EV-PDB-6PS4-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · 19.85 °C · ligands CLR, JRZ, OLA, OLC, SO4 XFEL beta2 AR structure by ligand exchange from Timolol to ICI-118551. · Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A) | unmapped |
| EV-PDB-6PS3-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 19.85 °C · ligands CLR, CVD, OLA, OLC, SO4 XFEL beta2 AR structure by ligand exchange from Timolol to Carvedilol. · Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A) | unmapped |
| EV-PDB-6PS2-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · 19.85 °C · ligands CLR, JTZ, OLA, OLB, OLC, SO4 XFEL beta2 AR structure by ligand exchange from Timolol to Alprenolol. · Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A) | unmapped |
| EV-PDB-6PS1-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · 19.85 °C · ligands CLR, OLA, OLC, SO4, TIM XFEL beta2 AR structure by ligand exchange from Alprenolol to Timolol. · Fusion protein of Beta-2 adrenergic receptor and T4 lysozyme (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-6PS0-1 RCSB PDB | xray | resolution: 3.4 Å | in vitro · 19.85 °C · ligands CAU, CLR, OLA, OLC, SO4 XFEL beta2 AR structure by ligand exchange from Alprenolol to Carazolol. · Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-6PRZ-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · 19.85 °C · ligands CLR, JTZ, OLA, OLC, SO4 XFEL beta2 AR structure by ligand exchange from Alprenolol to Alprenolol. · Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A) | unmapped |
| EV-PDB-6OBA-1 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -193.15 °C · pH 8 · ligands CLR, JTZ, M3J The beta2 adrenergic receptor bound to a negative allosteric modulator · Beta-2 adrenergic receptor,Lysozyme,Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-6NI3-4 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands P0G B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex · Endolysin,Beta-2 adrenergic receptor chimera (chains R) | active (Gs-coupled) · rule:b2ar-active-title · medium Title describes a G protein complex or a nanobody-stabilised active state. |
| EV-PDB-6N48-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -193.15 °C · pH 8 · ligands 1WV, KBY, P0G Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator · Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera (chains A) | unmapped |
| EV-PDB-6MXT-1 RCSB PDB | xray | resolution: 2.95934 Å | in vitro · -196.15 °C · pH 7.5 · ligands HTO, K5Y, MG, NI, OLA, OLC, P33 Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71 · Endolysin, Beta-2 adrenergic receptor chimera (chains A) | unmapped |
| EV-PDB-6E67-1 RCSB PDB | xray | resolution: 3.7 Å | in vitro · -193.15 °C · pH 7 · ligands P0G Structure of beta2 adrenergic receptor fused to a Gs peptide · Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera (chains A,B) | unmapped |
| EV-PDB-5X7D-1 RCSB PDB | xray | resolution: 2.703 Å | in vitro · -195.15 °C · pH 7.5 · ligands 8VS, ACM, BU1, CAU, CLR, EPE Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist · Chimera protein of Beta-2 adrenergic receptor and Lysozyme (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-5JQH-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -193.15 °C · pH 7.5 · ligands CAU, CLR Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60 · Endolysin,Beta-2 adrenergic receptor (chains A,B) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-5D6L-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · ligands 12P, ACM, BU1, CAU, CLR, PLM, SO4, branched: alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose beta2AR-T4L - CIM · Beta-2 adrenergic receptor,Endolysin,Beta-2 adrenergic receptor (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-5D5B-1 RCSB PDB | xray | resolution: 3.8 Å | in vitro · -173.15 °C · ligands ACM, BU1, CAU, CLR, PLM, SO4, branched: alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K · Beta-2 adrenergic receptor,Endolysin,Beta-2 adrenergic receptor (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-5D5A-1 RCSB PDB | xray | resolution: 2.4826 Å | in vitro · -173.15 °C · ligands 12P, ACM, BU1, CAU, CLR, PLM, SO4, branched: alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K · Beta-2 adrenergic receptor,Endolysin,Beta-2 adrenergic receptor (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-3PDS-1 RCSB PDB | xray | resolution: 3.5 Å | in vitro · -173.15 °C · pH 6.7 · ligands CLR, ERC, SO4 Irreversible Agonist-Beta2 Adrenoceptor Complex · Fusion protein Beta-2 adrenergic receptor/Lysozyme (chains A) | unmapped |
| EV-PDB-3P0G-1 RCSB PDB | xray | resolution: 3.5 Å | in vitro · -195.15 °C · pH 8 · ligands P0G Structure of a nanobody-stabilized active state of the beta2 adrenoceptor · Beta-2 adrenergic receptor, Lysozyme (chains A) | active (Gs-coupled) · curator:draft (unreviewed) · high Title: nanobody-stabilized active state. |
| EV-PDB-2R4R-1 RCSB PDB | xray | resolution: 3.4 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the human beta2 adrenoceptor · Beta-2 adrenergic receptor (chains A) | unmapped |
| EV-PDB-1GQ4-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -158.15 °C · pH 4.24 · ligands CL STRUCTURAL DETERMINANTS OF THE NHERF INTERACTION WITH BETA2AR AND PDGFR · EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50 (chains A) | unmapped |
| EV-PDB-8GEA-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#11 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEB-4 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#12 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEC-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#13 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GED-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#14 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEE-4 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#15 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEF-4 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#16 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEH-4 RCSB PDB | cryoem | resolution: 4 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#18 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEI-4 RCSB PDB | cryoem | resolution: 4.1 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#19 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GFV-4 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GFW-4 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GFX-4 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #3 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GFY-4 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #4 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GFZ-4 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG0-4 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG2-4 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #8 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG3-4 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #9 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG4-4 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #10 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG5-4 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #11 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG6-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #12 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG7-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #13 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG8-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #14 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG9-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGA-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #16 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGB-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #17 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGE-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #19 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGF-4 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #20 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGI-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGJ-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGK-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #3 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGM-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGO-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGP-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #8 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGQ-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #9 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGR-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #10 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGS-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #11 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGT-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #12 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGU-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #13 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGW-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGX-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #16 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GH0-1 RCSB PDB | cryoem | resolution: 4 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #19 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGZ-1 RCSB PDB | cryoem | resolution: 3.9 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #18 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGY-1 RCSB PDB | cryoem | resolution: 3.9 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #17 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGV-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #14 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGN-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGL-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #4 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GGC-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #18 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GG1-4 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEJ-4 RCSB PDB | cryoem | resolution: 4.2 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#20 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GEG-4 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#17 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8GE9-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#10 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8JJ8-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands H98 Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with a partial agonist · Beta-2 adrenergic receptor,Soluble cytochrome b562 (chains F) | unmapped |
| EV-PDB-8JJL-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands DZQ cryo-EM structure of the beta2-AR-mBRIL/1b3 Fab/Glue complex with a full agonist · Beta-2 adrenergic receptor,Soluble cytochrome b562 (chains A) | unmapped |
| EV-PDB-8JJO-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands JTZ Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist · Beta-2 adrenergic receptor,Beta-2 adrenergic receptor,Soluble cytochrome b562 (chains F) | unmapped |
| EV-PDB-8UHB-1 RCSB PDB | cryoem | resolution: 3.35 Å | in vitro · ligands WV8 Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex · Soluble cytochrome b562,Beta-2 adrenergic receptor,Trace amine-associated receptor 1 (chains A) | unmapped |
| EV-PDB-8UNL-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class A) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNM-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class B) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNN-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNO-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class D) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNP-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class E) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNQ-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class F) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNR-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class G) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNS-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class H) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNT-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class I) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNU-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class J) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNV-4 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class K) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNW-4 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class L) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNX-4 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class M) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNY-4 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UNZ-4 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class O) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UO0-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class P) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UO1-4 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I, GTP, MG CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class Q) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UO2-4 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro · ligands G1I, GTP CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class R) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UO3-4 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands G1I, GTP, MG CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class S) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8UO4-4 RCSB PDB | cryoem | resolution: 4 Å | in vitro · ligands G1I, GTP, MG CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class T) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-8W1V-1 RCSB PDB | xray | resolution: 3 Å | in vitro · -193.15 °C · ligands A1AE2, AV0 The beta2 adrenergic receptor bound to a bitopic ligand · Beta-2 adrenergic receptor,Endolysin (chains A,B) | unmapped |
| EV-PDB-8ZBE-1 RCSB PDB | cryoem | resolution: 3.24 Å | in vitro cryo-EM structure of the octreotide-bound SSTR5-Gi complex · Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein) (chains A) | unmapped |
| EV-PDB-8ZCJ-5 RCSB PDB | cryoem | resolution: 3.09 Å | in vitro Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex · Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein) (chains G) | unmapped |
| EV-PDB-8ZWG-1 RCSB PDB | cryoem | resolution: 2.87 Å | in vitro · ligands A1D9A cryoEM structure of JR14a bound C3aR-Gi complex · Beta-2 adrenergic receptor,C3a anaphylatoxin chemotactic receptor (chains A) | unmapped |
| EV-PDB-9BUY-5 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands A1ASM, CLR, KBY Structure of the LM189-Bound beta2AR-Gi Complex · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-9CHU-1 RCSB PDB | cryoem | resolution: 3.49 Å | in vitro · ligands E5E, FK5 Cryo-EM structure of calcineurin fused beta2 adrenergic receptor in norepinephrine bound inactive state · Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (chains A) | unmapped |
| EV-PDB-9CHV-1 RCSB PDB | cryoem | resolution: 3.95 Å | in vitro · ligands FK5 cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in apo state · Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (chains A) | unmapped |
| EV-PDB-9CHX-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands CAU, FK5 cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state · Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (chains A) | inactive (inverse agonist-bound) · rule:b2ar-inverse-agonist · medium Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive. |
| EV-PDB-9I52-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro · ligands A1IZU Dopamine 1 receptor:GaS complex bound to 19B · Beta-2 adrenergic receptor,D(1A) dopamine receptor (chains R) | unmapped |
| EV-PDB-9I54-4 RCSB PDB | cryoem | resolution: 2.72 Å | in vitro · ligands A1IZV Dopamine 1 receptor:GaS complex bound to 24 · Beta-2 adrenergic receptor,D(1A) dopamine receptor (chains R) | unmapped |
| EV-PDB-9L8L-5 RCSB PDB | cryoem | resolution: 3.22 Å | in vitro · ligands DR7, P0G Structure of GPCR megacomplex bound to agonists · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-9LW5-6 RCSB PDB | cryoem | resolution: 2.87 Å | in vitro · ligands LDP Cryo-EM structure of dopamine bound mut-beta2-Adrenergic Receptor beta2R-M16-miniGs-Gbeta1gamma2-Nb35-scFv16 complex · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-9Q3L-1 RCSB PDB | cryoem | resolution: 2.5 Å | in vitro · ligands A1CNS, C14, LFA, P0G CryoEM structure of beta2-adrenergic receptor dimer mediated by a biased allosteric modulator in lipid nanodisc · Beta-2 adrenergic receptor (chains A,B) | unmapped |
| EV-PDB-9RKF-1 RCSB PDB | xray | resolution: 2.45 Å | in vitro · 19.85 °C · ligands 12P, 1PE, A1JHU, CLR, EDO, GOL, OLC, PLM, SO4 Dark structure of beta-2 Adrenergic receptor with photoazolol in Dark state recorded at SwissFEL · Beta-2 adrenergic receptor,Endolysin (chains A) | unmapped |
| EV-PDB-9RKG-1 RCSB PDB | xray | resolution: 2.45 Å | in vitro · 19.85 °C · ligands 12P, 1PE, A1JHU, ACM, CLR, EDO, GOL, OLC, PLM, SO4 Mixed model refinement of beta-2 Adrenergic receptor with photoazolol in dark state and Light state, 10 seconds after light activation, recorded at SwissFEL · Beta-2 adrenergic receptor,Endolysin (chains A) | unmapped |
| EV-PDB-9RKH-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 19.85 °C · ligands 12P, A1JHU, CLR, EDO, GOL, OLC, PLM, SO4 Dark structure of beta-2 Adrenergic receptor with photoazolol in Dark state recorded at LCLS · Beta-2 adrenergic receptor,Endolysin (chains A) | unmapped |
| EV-PDB-9RKI-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · 19.85 °C · ligands 12P, 1PE, A1JHU, ACM, CLR, EDO, GOL, OLC, PLM, SO4 Mixed model refinement of beta-2 Adrenergic receptor with photoazolol in dark state and Light state, 17 nanoseconds after light activation, recorded at LCLS · Beta-2 adrenergic receptor,Endolysin (chains A) | unmapped |
| EV-PDB-9U4Y-6 RCSB PDB | cryoem | resolution: 2.67 Å | in vitro cryo-EM structure of Xenopus laevis GnRHR bound with mammal GnRH · Beta-2 adrenergic receptor,Gonadotropin-releasing hormone receptor (chains R) | unmapped |
| EV-PDB-9U9V-5 RCSB PDB | cryoem | resolution: 2.85 Å | in vitro · ligands B40 beta2-adrenergic receptor in complex with methamphetamine · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-PDB-9UAM-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands CLR, LTX, Y01 CysLTR2-LTC4-miniGq complex · Beta-2 adrenergic receptor,Cysteinyl leukotriene receptor 2,Oplophorus-luciferin 2-monooxygenase catalytic subunit (chains A) | unmapped |
| EV-PDB-9W3F-1 RCSB PDB | cryoem | resolution: 3.04 Å | in vitro · ligands BER Cryo-EM structure of the human beta2-adrenergic receptor in complex with a novel antagonist · Beta-2 adrenergic receptor,Endolysin (chains A) | unmapped |
| EV-PDB-9WEU-5 RCSB PDB | cryoem | resolution: 2.65 Å | in vitro · ligands A1EV3, CLR, G4C, PLM, SK0 D1R-Gs in complexed with SKF81297/LY3154207/BMSA1 · Beta-2 adrenergic receptor,D(1A) dopamine receptor,Engineered oplophorus-luciferin 2-monooxygenase catalytic subunit (chains R) | unmapped |
| EV-PDB-9WG0-5 RCSB PDB | cryoem | resolution: 2.59 Å | in vitro · ligands A1EV3, A1EWL, G4C, PLM, SK0 D1R-Gs in complexed with SKF81297/LY3154207/BMSA1/UNC10062 · Beta-2 adrenergic receptor,D(1A) dopamine receptor,Engineered oplophorus-luciferin 2-monooxygenase catalytic subunit (chains R) | unmapped |
| EV-PDB-9WG6-5 RCSB PDB | cryoem | resolution: 2.44 Å | in vitro · ligands A1EV3, A1EWF, G4C, LDP, PLM D1R-Gs in complexed with Dopamine/LY3154207/BMSA1/UNC9815 · Beta-2 adrenergic receptor,D(1A) dopamine receptor,Engineered oplophorus-luciferin 2-monooxygenase catalytic subunit (chains R) | unmapped |
| EV-PDB-8GH1-1 RCSB PDB | cryoem | resolution: 4.1 Å | in vitro · ligands G1I Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #20 of 20) · Beta-2 adrenergic receptor (chains R) | unmapped |
| EV-BMRB-36284 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Structure of the beta2 adrenergic receptor in the full agonist bound state · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-DISPROT-DP03692r001 DisProt | cd | disorder_region: 72 residues | in vitro DisProt DP03692: disorder, residues 342-413 · residues 342-413; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP03692r002 DisProt | nmr_shifts | disorder_region: 72 residues | in vitro DisProt DP03692: disorder, residues 342-413 · residues 342-413; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP03692r003 DisProt | saxs_sans | disorder_region: 72 residues | in vitro DisProt DP03692: disorder, residues 342-413 · residues 342-413; evidence: small-angle X-ray scattering evidence used in manual assertion | unmapped |
| EV-AFDB-AF-P07550-F1 AlphaFold DB | af_prediction | plddt: 79.12 pLDDT | in silico AlphaFold DB prediction AF-P07550-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-413 | unmapped |
| EV-SMASH-SMFS-000102 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Factors modulating the assembly of human β2-adrenergic receptor-β-arrestin complexes. · β2-adrenergic receptor; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004276 SMASH-BIO | force_spectroscopy | study_record | in vitro Mapping HA-tagged protein at the surface of living cells by atomic force microscopy. · β2-adrenergic receptor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005134 SMASH-BIO | force_spectroscopy | study_record | in vitro Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor. · β2-adrenergic receptor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
157 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.
Downloads
- Protein bundle (JSON)
- B2AR-inactive-cif (mmCIF, observed)
- B2AR-inactive-pdb (PDB, observed)
- B2AR-active-cif (mmCIF, observed)
- B2AR-active-pdb (PDB, observed)
- Curation file (YAML)