Integrin beta-1
UniProt P05556 · gene ITGB1 · Homo sapiens · 798 residues
265evidence items
0mapped to a state
0states
7techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | cd | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|---|
| No states defined yet. | |||||||||
Unmapped evidence: 265 of 265 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 2 | 0 |
| DisProt | 2 | 0 |
| RCSB PDB | 22 | 0 |
| SMASH-BIO | 238 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-4WK2-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7.2 · ligands CA, MG, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Metal Ion and Ligand Binding of Integrin · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-9P6S-2 RCSB PDB | cryoem | resolution: 2.61 Å | in vitro · ligands MN, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of human integrin alpha5beta1 in complex with fibronectin (FN 7-10) · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-9NAB-1 RCSB PDB | cryoem | resolution: 2.54 Å | in vitro Cryo-EM structure of the alpha5beta1 integrin headpiece with OS2966 Fab · Integrin beta-1 (chains A) | unmapped |
| EV-PDB-9EF2-2 RCSB PDB | cryoem | resolution: 3.36 Å | in vitro · ligands CA, MN, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin candidate 2, open conformation · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-9DIA-2 RCSB PDB | cryoem | resolution: 2.97 Å | in vitro · ligands CA, MN, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin candidate 2 · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-9CKV-2 RCSB PDB | cryoem | resolution: 3.19 Å | in vitro · ligands CA, MN, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-9B9K-2 RCSB PDB | cryoem | resolution: 2.7 Å | in vitro · ligands CA, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Integrin alpha-5 beta-1 in complex with MINT1526A Fab · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-9B9J-2 RCSB PDB | cryoem | resolution: 2.6 Å | in vitro · ligands CA, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Integrin alpha-5 beta-1 in complex with BIIG2 Fab · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-8W30-2 RCSB PDB | xray | resolution: 2.45 Å | in vitro · -173.15 °C · ligands A1AFA, CA, NAG, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Crystal structure of alpha-V beta-1 integrin headpiece in complex with TR01225179 · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-8RPQ-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 6.5 Solution NMR structure of Integrin beta-1 TMD · Integrin beta-1 (chains A) | unmapped |
| EV-PDB-7NXD-2 RCSB PDB | cryoem | resolution: 4.6 Å | in vitro · ligands CA, MG, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-7NWL-2 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands MN, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-7CEC-2 RCSB PDB | cryoem | resolution: 3.9 Å | in vitro · ligands CA, MN, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Structure of alpha6beta1 integrin in complex with laminin-511 · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-7CEB-2 RCSB PDB | xray | resolution: 2.89 Å | in vitro · -173.15 °C · ligands CA, MG, NAG Crystal structure of alpha6beta1 integrin headpiece · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-4WK4-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7.2 · ligands CA, MG, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Metal Ion and Ligand Binding of Integrin · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-4WK0-2 RCSB PDB | xray | resolution: 1.78 Å | in vitro · -173.15 °C · pH 7.2 · ligands CA, MG, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Metal Ion and Ligand Binding of Integrin · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-4WJK-2 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 7.2 · ligands CA, MG, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Metal Ion and Ligand Binding of Integrin · Integrin beta-1 (chains B) | unmapped |
| EV-PDB-4DX9-2 RCSB PDB | xray | resolution: 2.99 Å | in vitro · -173.15 °C · pH 6.5 ICAP1 in complex with integrin beta 1 cytoplasmic tail · Integrin beta-1 (chains 6,7,8,9,B,D,F,H,J,L,N,P,R,T,V,X,Z,b,d,f,h,j,l,n,p,r,t,v,x,z) | unmapped |
| EV-PDB-3VI4-2 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -183.15 °C · pH 6.5 · ligands CA, MG, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Crystal structure of alpha5beta1 integrin headpiece in complex with RGD peptide · Integrin beta-1 (chains B,D) | unmapped |
| EV-PDB-3VI3-2 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -183.15 °C · pH 6.5 · ligands CA, MG, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Crystal structure of alpha5beta1 integrin headpiece (ligand-free form) · Integrin beta-1 (chains B,D) | unmapped |
| EV-PDB-3T9K-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 5 · ligands SO4, ZN Crystal Structure of ACAP1 C-portion mutant S554D fused with integrin beta1 peptide · Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1,Peptide from Integrin beta-1 (chains A,B) | unmapped |
| EV-PDB-3G9W-2 RCSB PDB | xray | resolution: 2.165 Å | in vitro · -173.15 °C · pH 7 · ligands GOL, PEG Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail · Integrin beta-1D (chains C,D) | unmapped |
| EV-BMRB-16159 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.1 Beta1A Integrin Cytoplasmic Tail 1H and 15N Chemical Shift Assignments · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34892 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 6.5 Solution NMR structure of Integrin beta-1 TMD · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-DISPROT-DP01748r002 DisProt | cd | disorder_region: 47 residues | in vitro DisProt DP01748: disorder, residues 752-798 · residues 752-798; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01748r005 DisProt | xray | disorder_region: 15 residues | in vitro DisProt DP01748: disorder to order, residues 784-798 · residues 784-798; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-AFDB-AF-P05556-F1 AlphaFold DB | af_prediction | plddt: 85.88 pLDDT | in silico AlphaFold DB prediction AF-P05556-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-798 | unmapped |
| EV-SMASH-SMFS-000019 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 8 Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000089 SMASH-BIO | force_spectroscopy | study_record | in cell Effects of Ligand Mobility on Ligand-Receptor Interactions Driving Integrin-Mediated Cell Adhesion. · Integrin; tension sensors; experiment class: membrane_mechanics, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000122 SMASH-BIO | force_spectroscopy | study_record | in cell HUH-Enabled Programmable Antibody-DNA Conjugates for Profiling Receptor- Specific Cellular Mechanics · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000161 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 8 Leader cell myosin 10 controls adhesion dynamics, invasion, and EMT pathway activation. · Integrin; tension sensors; experiment class: force_generation_motor, nucleic_acid_protein_interaction, receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-000173 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.6 Matrix Mechanics Governs Mechano-Metabolic Adaptation across Cancer Grades in Bladder Spheroids. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-000175 SMASH-BIO | force_spectroscopy | study_record | in cell Measuring cellular force using DNA-based tension probes: from ensemble to single-molecule studies. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000188 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanobiology of the diabetic cardiomyocyte: insulin signaling, titin elasticity, and multiscale mechanical dysfunction. · Integrin; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-000199 SMASH-BIO | force_spectroscopy | study_record | in cell Molecular tension tether based on electrochemiluminescence sensor for cellular mechanics measurement. · Integrin; tension sensors; experiment class: force_generation_motor, force_generation_polymerization, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000267 SMASH-BIO | force_spectroscopy | study_record | in vitro Selective inhibition of platelet inflammatory tether formation via force-modulated vibrational states of integrin αIIbβ3. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000280 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-Molecule AFM-Based Force Spectroscopy Reveals VLA-4/VCAM-1 Interactions Underlying Chemokine-Independent B16 Melanoma Cell Arrest · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000281 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Single-Molecule AFM-Based Force Spectroscopy Reveals VLA-4/VCAM-1 Interactions Underlying Chemokine-Independent B16 Melanoma Cell Arrest. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000293 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule force spectroscopy reveals a high-force requirement for dissociation of integrin transmembrane domains. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000307 SMASH-BIO | force_spectroscopy | study_record | in vitro Stochastic thresholds in hemostasis and thrombosis: A multiscale biophysical framework from transcriptional bursting to thrombin propagation. · Integrin; force spectroscopy unspecified; experiment class: force_generation_polymerization, receptor_ligand_adhesion, rheology_cell, translation_transcription_replication, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000317 SMASH-BIO | force_spectroscopy | study_record | in vitro Talin controls the spatial distribution of vinculin tension in focal adhesions · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000318 SMASH-BIO | force_spectroscopy | study_record | in vitro Talin controls the spatial distribution of vinculin tension in focal adhesions · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000349 SMASH-BIO | force_spectroscopy | study_record | in vitro α5β1 and αvβ3 integrins employ two distinct adhesion strengthening modes to respond to fibronectin stiffness within seconds of initiating adhesion · Integrin; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000361 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 A portable and sensitive DNA-based electrochemical sensor for detecting piconewton-scale cellular forces. · Integrin; magnetic tweezers; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000424 SMASH-BIO | force_spectroscopy | study_record | in vitro Direct measurement of SARS-CoV-2 spike RBD binding to integrin αvβ6 by single-molecule force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000461 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 7.5 High-throughput Flow-cytometry Measurement of Cellular Mechanotype Based on Rupture and Delivery of DNA Tension Probes into Cells. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000468-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 133.2 nN | in vitro Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000468-r1 SMASH-BIO | force_spectroscopy | adhesion_force: 78.4 nN | in vitro Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000472 SMASH-BIO | force_spectroscopy | study_record | in cell Integrin Tension Represents the Directed Differentiation of Mesenchymal Stem Cells via Mechanoadaptation. · Integrin; tension sensors; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000473 SMASH-BIO | force_spectroscopy | study_record | in vitro Interaction of integrin αvβ3 and fibronectin under fluid shear forces: implications for tumor cell adhesion and migration. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000489 SMASH-BIO | force_spectroscopy | study_record | in vitro Load-dependent RGD-context sensing via αV-class integrin reprograms cellular adhesion and mechanics within seconds · Integrin; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000491 SMASH-BIO | force_spectroscopy | study_record | in cell Locked Nucleic Acid-Modified Force Probe Reveals High-Force Regulation of Yes-Associated Protein through Talin-Vinculin in Breast Cancer. · Integrin; tension sensors; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000507 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Mechanical forces and ligand binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000515 SMASH-BIO | force_spectroscopy | study_record | in vitro Model of integrin binding as a function of light-induced variations in forces exerted on cells via RGD-terminated, photoswitchable azobenzene surfaces · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000696 SMASH-BIO | force_spectroscopy | study_record | in vitro Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000724 SMASH-BIO | force_spectroscopy | study_record | in vitro DNA-based ForceChrono Probes for Deciphering Single-Molecule Force Dynamics in Living Cells · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000725 SMASH-BIO | force_spectroscopy | study_record | in cell DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000730 SMASH-BIO | force_spectroscopy | study_record | in vitro Determination of single-molecule loading rate during mechanotransduction in cell adhesion. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000731 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 7.4 Develop Tandem Tension Sensor to Gauge Integrin-Transmitted Molecular Forces. · Integrin; tension sensors; experiment class: force_generation_motor, nucleic_acid_mechanics, receptor_ligand_adhesion, rheology_cell, unfolding_nucleic_acid | unmapped |
| EV-SMASH-SMFS-000747 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 7.4 Electrochemical DNA-based sensors for measuring cell-generated forces. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, unfolding_nucleic_acid | unmapped |
| EV-SMASH-SMFS-000803 SMASH-BIO | force_spectroscopy | study_record | in vitro Integrin mechanosensing relies on a pivot-clip mechanism to reinforce cell adhesion. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000827 SMASH-BIO | force_spectroscopy | study_record | in cell Measuring Integrin Force Loading Rates Using a Two-Step DNA Tension Sensor. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000828 SMASH-BIO | force_spectroscopy | study_record | in cell Measuring integrin force loading rates using a two-step DNA tension sensor · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000871 SMASH-BIO | force_spectroscopy | study_record | in vitro Nanoscale dynamical investigation of the hemoglobin complex with the bacterial protein IsdB: is their interaction stabilized by catch bonds? · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000952 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 7.4 Smart Biointerfaces via Click Chemistry-Enabled Nanopatterning of Multiple Bioligands and DNA Force Sensors. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000954 SMASH-BIO | force_spectroscopy | study_record | in cell Split Luciferase Molecular Tension Sensors for Bioluminescent Readout of Mechanical Forces in Biological Systems. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000972 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000974 SMASH-BIO | force_spectroscopy | study_record | in vitro Tension-induced adhesion mode switching: the interplay between focal adhesions and clathrin-containing adhesion complexes · Integrin; afm smfs; experiment class: force_generation_motor, membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000976 SMASH-BIO | force_spectroscopy | study_record | in vitro The Effects of the Carrier and Ligand Spatial Conformation on RNA Nanodrug Cell Delivery. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001001 SMASH-BIO | force_spectroscopy | study_record | in vitro Tunable Cell-Adhesive Surfaces by Surface-Initiated Photoinduced Electron-Transfer-Reversible Addition-Fragmentation Chain-Transfer Polymerization. · Integrin; afm smfs; experiment class: force_generation_polymerization, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001030 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 A Programmable DNA Origami Nanospring That Reports Dynamics of Single Integrin Motion, Force Magnitude and Force Orientation in Living Cells. · Integrin; acoustic force spectroscopy; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001068 SMASH-BIO | force_spectroscopy | study_record | in vitro Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001069 SMASH-BIO | force_spectroscopy | study_record | in vitro Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001105 SMASH-BIO | force_spectroscopy | study_record | in cell Defining Integrin Tension Required for Chemotaxis of Metastatic Breast Cancer Cells in Confinement. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001135 SMASH-BIO | force_spectroscopy | study_record | in cell Electrochemical DNA-based sensors for measuring cell-generated forces · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, unfolding_nucleic_acid | unmapped |
| EV-SMASH-SMFS-001153 SMASH-BIO | force_spectroscopy | study_record | in cell Exploring Mechanical Responses of Cells to Geometric Information Using Micropatterned DNA-Based Molecular Tension Probes. · Integrin; tension sensors; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001186 SMASH-BIO | force_spectroscopy | study_record | in cell Hydrogel-based molecular tension fluorescence microscopy for investigating receptor-mediated rigidity sensing. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001198 SMASH-BIO | force_spectroscopy | study_record | in vitro Integrin Mechanosensing relies on Pivot-clip Mechanism to Reinforce Cell Adhesion · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001209 SMASH-BIO | force_spectroscopy | study_record | in vitro Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond. · Integrin; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001210 SMASH-BIO | force_spectroscopy | study_record | in vitro Living cells as a biological analog of optical tweezers - a non-invasive microrheology approach. · Integrin; optical tweezers; experiment class: force_generation_motor, membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001250 SMASH-BIO | force_spectroscopy | study_record | in vitro Multiscale Computational Framework to Investigate Integrin Mechanosensing and Cell Adhesion · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001280 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing mechanical interaction of immune receptors and cytoskeleton by membrane nanotube extraction. · Integrin; optical tweezers; experiment class: membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001290 SMASH-BIO | force_spectroscopy | study_record | in vitro Rapid Regulation of Cardiomyocytes Adhesion on Substrates with Varied Modulus via Mechanical Cues. · Integrin; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-001347 SMASH-BIO | force_spectroscopy | study_record | in vitro Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001350 SMASH-BIO | force_spectroscopy | study_record | in vitro The Force-Dependent Mechanism of an Integrin α4β7-MAdCAM-1 Interaction. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001374 SMASH-BIO | force_spectroscopy | study_record | in cell Vinculin transmits high-level integrin tensions that are dispensable for focal adhesion formation. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001444 SMASH-BIO | force_spectroscopy | study_record | in cell Characterization of Integrin Molecular Tension of Human Breast Cancer Cells on Anisotropic Nanopatterns. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001468 SMASH-BIO | force_spectroscopy | study_record | in vitro Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001512 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Facile detection of mechanical forces across proteins in cells with STReTCh. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001523 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-enhanced biophysical connectivity of platelet β3 integrin signaling through Talin is predicted by steered molecular dynamics simulations. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001589 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Mechanical regulation of talin through binding and history-dependent unfolding. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001597 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechano-Redox Control of Integrins in Thromboinflammation. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001671 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing mechanical interaction of immune receptors and cytoskeleton by membrane nanotube extraction · Integrin; optical tweezers; experiment class: membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001679 SMASH-BIO | force_spectroscopy | study_record | in vitro Pulling, failing, and adaptive mechanotransduction of macrophage filopodia. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001700 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 9 ST6Gal-I-mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001701 SMASH-BIO | force_spectroscopy | study_record | in vitro STReTCh: a strategy for facile detection of mechanical forces across proteins in cells · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001712 SMASH-BIO | force_spectroscopy | study_record | in cell Single-Molecule Force Imaging Reveals That Podosome Formation Requires No Extracellular Integrin-Ligand Tensions or Interactions. · Integrin; tension sensors; experiment class: force_generation_motor, force_generation_polymerization, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001713 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-Molecule Force Probing of RGD-Binding Integrins on Pancreatic Cancer Cells. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001748 SMASH-BIO | force_spectroscopy | study_record | in cell Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001750 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.1 The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin. · Integrin; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001763 SMASH-BIO | force_spectroscopy | study_record | in vitro The glycocalyx affects the mechanotransductive perception of the topographical microenvironment. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001778 SMASH-BIO | force_spectroscopy | study_record | in cell Unbreakable DNA tension probes show that cell adhesion receptors detect the molecular force-extension curve of their ligands · Integrin; tension sensors; experiment class: nucleic_acid_mechanics, receptor_ligand_adhesion, rheology_cell, unfolding_nucleic_acid, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001783 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Unraveling the molecular determinants of the anti-phagocytic protein cloak of plague bacteria. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001798 SMASH-BIO | force_spectroscopy | study_record | in cell A Reversible shearing DNA-based tension probe for cellular force measurement · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001806 SMASH-BIO | force_spectroscopy | study_record | in cell A reversible shearing DNA probe for visualizing mechanically strong receptors in living cells. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001834 SMASH-BIO | force_spectroscopy | study_record | in vitro Biomechanics of Neutrophil Tethers. · Integrin; optical tweezers; experiment class: membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001871 SMASH-BIO | force_spectroscopy | study_record | in vitro Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-αVβ6/TGF-β Signaling Cascade · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001917 SMASH-BIO | force_spectroscopy | study_record | in vitro Evaluating the single-molecule interactions between targeted peptides and the receptors on living cell membrane. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001918-r0 SMASH-BIO | force_spectroscopy | rupture_force: 17.85 pN ± 0.63 | in vitro Examining the Effect of Kindlin-3 Binding Site Mutation on LFA-1-ICAM-1 Bonds by Force Measuring Optical Tweezers. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001918-r1 SMASH-BIO | force_spectroscopy | loading_rate: 30.21 pN/s ± 4.35 | in vitro Examining the Effect of Kindlin-3 Binding Site Mutation on LFA-1-ICAM-1 Bonds by Force Measuring Optical Tweezers. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001918-r2 SMASH-BIO | force_spectroscopy | rupture_force: 10.08 pN ± 0.88 | in vitro Examining the Effect of Kindlin-3 Binding Site Mutation on LFA-1-ICAM-1 Bonds by Force Measuring Optical Tweezers. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001972 SMASH-BIO | force_spectroscopy | study_record | in vitro Integrin α2β1 as a negative regulator of the laminin receptors α6β1 and α6β4. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001987-r0 SMASH-BIO | force_spectroscopy | rupture_force: 250 pN | in vitro MD Simulations on a Well-Built Docking Model Reveal Fine Mechanical Stability and Force-Dependent Dissociation of Mac-1/GPIbα Complex. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002102-r0 SMASH-BIO | force_spectroscopy | unfolding_force: 6 pN | in vitro Real Time Observation of Chaperone-modulated Talin Mechanics Under Single Molecule Resolution · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002103-r0 SMASH-BIO | force_spectroscopy | unfolding_force: 6 pN | in vitro Real time observation of chaperone-modulated talin mechanics with single molecule resolution · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002111 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Reovirus directly engages integrin to recruit clathrin for entry into host cells. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002170 SMASH-BIO | force_spectroscopy | study_record | in cell Super-resolved visualization of single DNA-based tension sensors in cell adhesion. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002173 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002225 SMASH-BIO | force_spectroscopy | study_record | in vitro AFM Force Spectroscopy Reveals the Role of Integrins and Their Activation in Cell-Biomaterial Interactions. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002231 SMASH-BIO | force_spectroscopy | study_record | in vitro Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002232 SMASH-BIO | force_spectroscopy | study_record | in vitro Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002247 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Application of Force to a Syndecan-4 Containing Complex With Thy-1-αVβ3 Integrin Accelerates Neurite Retraction. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002301 SMASH-BIO | force_spectroscopy | study_record | in vitro Different Vinculin Binding Sites Use the Same Mechanism to Regulate Directional Force Transduction. · Integrin; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002317 SMASH-BIO | force_spectroscopy | study_record | in cell EGFR activation attenuates the mechanical threshold for integrin tension and focal adhesion formation. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002445 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular interactions and forces of adhesion between single human neural stem cells and gelatin methacrylate hydrogels of varying stiffness. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-002462 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.1 Nanoscale Molecular Quantification of Stem Cell-Hydrogel Interactions. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002466 SMASH-BIO | force_spectroscopy | study_record | in vitro Nitrosative stress affects the interaction of integrin alphaIIbbeta3 with its ligands. · Integrin; afm smfs; experiment class: membrane_mechanics, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002491-r0 SMASH-BIO | force_spectroscopy | rupture_force: 200 pN | in vitro Prediction of Catch-Slip Bond Transition of Kindlin2/β3 Integrin via Steered Molecular Dynamics Simulation. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002495 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing the recognition specificity of αVβ1 integrin and syndecan-4 using force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002565 SMASH-BIO | force_spectroscopy | study_record | in vitro The C-terminal actin binding domain of talin forms an asymmetric catch bond with F-actin · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002689-r0 SMASH-BIO | force_spectroscopy | bond_lifetime: 1000 s | in vitro Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin-talin/α-catenin linkages. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002693 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Distinct Binding Interactions of α5β1-Integrin and Proteoglycans with Fibronectin. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002703-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 0.64 nN ± 0.03 | in vitro Effect of monophasic pulsed stimulation on live single cell de-adhesion on conducting polymers with adsorbed fibronectin as revealed by single cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002719 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 4.6 Fast Force Loading Disrupts Molecular Binding Stability in Human and Mouse Cell Adhesions. · Integrin; biomembrane force probe; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002764 SMASH-BIO | force_spectroscopy | study_record | in vitro Kindlin Is Mechanosensitive: Force-Induced Conformational Switch Mediates Cross-Talk among Integrins. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002864 SMASH-BIO | force_spectroscopy | study_record | in cell Real-Time Measurement of Molecular Tension during Cell Adhesion and Migration Using Multiplexed Differential Analysis of Tension Gauge Tethers. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002964 SMASH-BIO | force_spectroscopy | study_record | in vitro Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002999 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis. · Integrin; biomembrane force probe; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003023 SMASH-BIO | force_spectroscopy | study_record | in cell Cdc42-dependent modulation of rigidity sensing and cell spreading in tumor repopulating cells. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003088-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 0.65 nN | in vitro Effect of electrochemical oxidation and reduction on cell de-adhesion at the conducting polymer-live cell interface as revealed by single cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003088-r1 SMASH-BIO | force_spectroscopy | adhesion_force: 0.4 nN | in vitro Effect of electrochemical oxidation and reduction on cell de-adhesion at the conducting polymer-live cell interface as revealed by single cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003150 SMASH-BIO | force_spectroscopy | study_record | in cell Keratocytes Generate High Integrin Tension at the Trailing Edge to Mediate Rear De-adhesion during Rapid Cell Migration. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003183 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Mechano-redox control of integrin de-adhesion. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003306 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003325 SMASH-BIO | force_spectroscopy | study_record | in vitro Temporal and molecular dynamics of human metastatic breast carcinoma cell adhesive interactions with human bone marrow endothelium analyzed by single-cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003329 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.3 The 95RGD97 sequence on the Aα chain of fibrinogen is essential for binding to its erythrocyte receptor. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003354 SMASH-BIO | force_spectroscopy | study_record | in vitro Toxic HypF-N Oligomers Selectively Bind the Plasma Membrane to Impair Cell Adhesion Capability. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003363 SMASH-BIO | force_spectroscopy | study_record | in vitro Unbinding Kinetics of Syndecans by Single-Molecule Force Spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003384 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003431 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.8 Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003433-r0 SMASH-BIO | force_spectroscopy | velocity: 10 µm/s | in vitro Characterisation of cellular adhesion reinforcement by multiple bond force spectroscopy in alveolar epithelial cells. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003458 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Development of fusogenic glass surfaces that impart spatiotemporal control over macrophage fusion: Direct visualization of multinucleated giant cell formation. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003459 SMASH-BIO | force_spectroscopy | study_record | in vitro Dimerization of Cell-Adhesion Molecules Can Increase Their Binding Strength. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003496 SMASH-BIO | force_spectroscopy | study_record | in vitro Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003503-r0 SMASH-BIO | force_spectroscopy | velocity: 10 µm/s | in vitro Exposure to Bordetella pertussis adenylate cyclase toxin affects integrin-mediated adhesion and mechanics in alveolar epithelial cells. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003508 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices. · Integrin; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003516 SMASH-BIO | force_spectroscopy | study_record | in vitro Force regulated conformational change of integrin αVβ3. · Integrin; biomembrane force probe; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003533 SMASH-BIO | force_spectroscopy | study_record | in vitro High-Frequency Mechanostimulation of Cell Adhesion. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003558 SMASH-BIO | force_spectroscopy | study_record | in vitro Investigating cell-substrate and cell-cell interactions by means of single-cell-probe force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003584 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003599 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular Tension Probes for Imaging Forces at the Cell Surface. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-003606 SMASH-BIO | force_spectroscopy | study_record | in cell Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1. · Integrin; tension sensors; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003673 SMASH-BIO | force_spectroscopy | study_record | in vitro Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003682 SMASH-BIO | force_spectroscopy | study_record | in vitro Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003737-r1 SMASH-BIO | force_spectroscopy | rupture_force: 60 pN | in vitro · pH 7.4 Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003738 SMASH-BIO | force_spectroscopy | study_record | in vitro Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003796 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. · Integrin; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003798 SMASH-BIO | force_spectroscopy | study_record | in vitro β1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003822 SMASH-BIO | force_spectroscopy | study_record | in vitro Analysis of the effect of LRP-1 silencing on the invasive potential of cancer cells by nanomechanical probing and adhesion force measurements using atomic force microscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003835 SMASH-BIO | force_spectroscopy | study_record | in vitro Cells Sensing Mechanical Cues: Stiffness Influences the Lifetime of Cell-Extracellular Matrix Interactions by Affecting the Loading Rate. · Integrin; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003844 SMASH-BIO | force_spectroscopy | study_record | in vitro Computational design of peptide-Au cluster probe for sensitive detection of α(IIb)β3 integrin. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003883 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.6 Effects of Plectin Depletion on Keratin Network Dynamics and Organization. · Integrin; magnetic tweezers; experiment class: force_generation_polymerization, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003913 SMASH-BIO | force_spectroscopy | study_record | in vitro Glycoprotein Ib-IX-V Complex Transmits Cytoskeletal Forces That Enhance Platelet Adhesion. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003925 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Improving Osteoblast Response In Vitro by a Nanostructured Thin Film with Titanium Carbide and Titanium Oxides Clustered around Graphitic Carbon. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003933 SMASH-BIO | force_spectroscopy | study_record | in cell · pH 7.6 Integrins outside focal adhesions transmit tensions during stable cell adhesion. · Integrin; tension sensors; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003981 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.8 Nanomechanical and Thermophoretic Analyses of the Nucleotide-Dependent Interactions between the AAA(+) Subunits of Magnesium Chelatase. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004024 SMASH-BIO | force_spectroscopy | study_record | in vitro Rapid Reversible Photoswitching of Integrin-Mediated Adhesion at the Single-Cell Level. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004028 SMASH-BIO | force_spectroscopy | study_record | in vitro Reinforcement of integrin-mediated T-Lymphocyte adhesion by TNF-induced Inside-out Signaling. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004083 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 The mechanical response of talin. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004121 SMASH-BIO | force_spectroscopy | study_record | in vitro AFM force spectroscopy reveals how subtle structural differences affect the interaction strength between Candida albicans and DC-SIGN. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004227 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004233 SMASH-BIO | force_spectroscopy | study_record | in vitro Helical buckling of actin inside filopodia generates traction. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004247 SMASH-BIO | force_spectroscopy | study_record | in vitro In PC3 prostate cancer cells ephrin receptors crosstalk to β1-integrins to strengthen adhesion to collagen type I. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004252 SMASH-BIO | force_spectroscopy | study_record | in cell Integrin Molecular Tension within Motile Focal Adhesions. · Integrin; tension sensors; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004311 SMASH-BIO | force_spectroscopy | study_record | in vitro Non-channel mechanosensors working at focal adhesion-stress fiber complex. · Integrin; force spectroscopy unspecified; experiment class: membrane_mechanics, receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004366 SMASH-BIO | force_spectroscopy | study_record | in cell Single molecular force across single integrins dictates cell spreading. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004513 SMASH-BIO | force_spectroscopy | study_record | in cell DNA-based digital tension probes reveal integrin forces during early cell adhesion. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion, unfolding_nucleic_acid | unmapped |
| EV-SMASH-SMFS-004554 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 5.3 Force-induced globule-coil transition in laminin binding protein and its role for viral-cell membrane fusion. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004576 SMASH-BIO | force_spectroscopy | study_record | in cell Integrin-generated forces lead to streptavidin-biotin unbinding in cellular adhesions. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004643 SMASH-BIO | force_spectroscopy | study_record | in cell Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004662 SMASH-BIO | force_spectroscopy | study_record | in vitro Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes. · Integrin; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004786 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.3 Activation induced morphological changes and integrin αIIbβ3 activity of living platelets. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004790 SMASH-BIO | force_spectroscopy | study_record | in vitro Agonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers. · Integrin; afm smfs; experiment class: membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004798 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Application of catalyst-free click reactions in attaching affinity molecules to tips of atomic force microscopy for detection of protein biomarkers. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004834 SMASH-BIO | force_spectroscopy | study_record | in cell Defining single molecular forces required to activate integrin and notch signaling. · Integrin; tension sensors; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004835 SMASH-BIO | force_spectroscopy | study_record | in vitro Delineating breast cancer cell interactions with engineered bone microenvironments. · Integrin; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004859 SMASH-BIO | force_spectroscopy | study_record | in vitro Epithelial-mesenchymal transition enhances nanoscale actin filament dynamics of ovarian cancer cells. · Integrin; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004916 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004981 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 PROBING αIIbβ3: LIGAND INTERACTIONS BY DYNAMIC FORCE SPECTROSCOPY AND SURFACE PLASMON RESONANCE. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004993 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing the interaction forces of prostate cancer cells with collagen I and bone marrow derived stem cells on the single cell level. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005076-r0 SMASH-BIO | force_spectroscopy | loading_rate: 18 pN/s | in vitro Two barriers or not? Dynamic force spectroscopy on the integrin α7β1 invasin complex. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005100 SMASH-BIO | force_spectroscopy | study_record | in vitro AFM Force Spectroscopy of Protein Interaction · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005118 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005190-r0 SMASH-BIO | force_spectroscopy | stall_force: 8 pN | in vitro Filopodium retraction is controlled by adhesion to its tip. · Integrin; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005190-r1 SMASH-BIO | force_spectroscopy | stall_force: 10 pN | in vitro Filopodium retraction is controlled by adhesion to its tip. · Integrin; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005253 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanotransduction through fibronectin-integrin focal adhesion in microvascular smooth muscle cells: is calcium essential? · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005273 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8.4 Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells. · Integrin; biomembrane force probe; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005312 SMASH-BIO | force_spectroscopy | study_record | in vitro Resolving two-dimensional kinetics of the integrin αIIbβ3-fibrinogen interactions using binding-unbinding correlation spectroscopy. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005314 SMASH-BIO | force_spectroscopy | study_record | in vitro Revealing non-genetic adhesive variations in clonal populations by comparative single-cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005364 SMASH-BIO | force_spectroscopy | study_record | in vitro The assembly of nonadhesive fibrinogen matrices depends on the αC regions of the fibrinogen molecule. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005405 SMASH-BIO | force_spectroscopy | study_record | in vitro 2B4 engagement mediates rapid LFA-1 and actin-dependent NK cell adhesion to tumor cells as measured by single cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005410 SMASH-BIO | force_spectroscopy | study_record | in vitro A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005421 SMASH-BIO | force_spectroscopy | study_record | in vitro Adhesion frequency assay for in situ kinetics analysis of cross-junctional molecular interactions at the cell-cell interface. · Integrin; biomembrane force probe; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005450 SMASH-BIO | force_spectroscopy | study_record | in vitro Cancer cells regulate biomechanical properties of human microvascular endothelial cells. · Integrin; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005479 SMASH-BIO | force_spectroscopy | study_record | in vitro Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005587 SMASH-BIO | force_spectroscopy | study_record | in vitro Negative feedback from integrins to cadherins: a micromechanical study. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005683 SMASH-BIO | force_spectroscopy | study_record | in vitro The single-molecule mechanics of the latent TGF-β1 complex. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005692 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Variations on fibrinogen-erythrocyte interactions during cell aging. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005722 SMASH-BIO | force_spectroscopy | study_record | in vitro Atomic force microscopy-based molecular recognition of a fibrinogen receptor on human erythrocytes. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005736 SMASH-BIO | force_spectroscopy | study_record | in vitro Characterization of glycoprotein E C-end of West Nile virus and evaluation of its interaction force with alphaVbeta3 integrin as putative cellular receptor. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005752 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Control of integrin alphaIIb beta3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. · Integrin; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005819 SMASH-BIO | force_spectroscopy | study_record | in vitro Integrin and glycocalyx mediated contributions to cell adhesion identified by single cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005826 SMASH-BIO | force_spectroscopy | study_record | in vitro Long-lived, high-strength states of ICAM-1 bonds to beta2 integrin, I: lifetimes of bonds to recombinant alphaLbeta2 under force. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005827 SMASH-BIO | force_spectroscopy | study_record | in vitro Long-lived, high-strength states of ICAM-1 bonds to beta2 integrin, II: lifetimes of LFA-1 bonds under force in leukocyte signaling. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005835 SMASH-BIO | force_spectroscopy | study_record | in vitro Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005851 SMASH-BIO | force_spectroscopy | study_record | in vitro Model for how retrograde actin flow regulates adhesion traction stresses. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005881 SMASH-BIO | force_spectroscopy | study_record | in vitro Origin of the nonadhesive properties of fibrinogen matrices probed by force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005896 SMASH-BIO | force_spectroscopy | study_record | in vitro Quantifying cellular adhesion to extracellular matrix components by single-cell force spectroscopy. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005908 SMASH-BIO | force_spectroscopy | study_record | in vitro Shear-stabilized rolling behavior of E. coli examined with simulations. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005939 SMASH-BIO | force_spectroscopy | study_record | in vitro Temperature modulation of integrin-mediated cell adhesion. · Integrin; force spectroscopy unspecified; experiment class: membrane_mechanics, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005945 SMASH-BIO | force_spectroscopy | study_record | in vitro The effect of unlocking RGD-motifs in collagen I on pre-osteoblast adhesion and differentiation. · Integrin; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006021 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Demonstration of catch bonds between an integrin and its ligand. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006213 SMASH-BIO | force_spectroscopy | study_record | in vitro Stretching single talin rod molecules activates vinculin binding. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006257 SMASH-BIO | force_spectroscopy | study_record | in vitro A comparative study of living cell micromechanical properties by oscillatory optical tweezers. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006270 SMASH-BIO | force_spectroscopy | study_record | in vitro BCR/ABL expression of myeloid progenitors increases beta1-integrin mediated adhesion to stromal cells. · Integrin; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-006337 SMASH-BIO | force_spectroscopy | study_record | in vitro Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006485 SMASH-BIO | force_spectroscopy | study_record | in vitro TPA primes alpha2beta1 integrins for cell adhesion. · Integrin; afm smfs; experiment class: membrane_mechanics, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006519 SMASH-BIO | force_spectroscopy | study_record | in vitro Alpha-actinin-4 is required for normal podocyte adhesion. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006544 SMASH-BIO | force_spectroscopy | study_record | in vitro Contributions of galectin-3 and -9 to epithelial cell adhesion analyzed by single cell force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006687 SMASH-BIO | force_spectroscopy | study_record | in vitro Revealing early steps of alpha2beta1 integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy. · Integrin; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006707 SMASH-BIO | force_spectroscopy | study_record | in vitro Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells. · Integrin; magnetic tweezers; experiment class: force_generation_polymerization, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006713 SMASH-BIO | force_spectroscopy | study_record | in vitro Studying integrin-mediated cell adhesion at the single-molecule level using AFM force spectroscopy. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006745 SMASH-BIO | force_spectroscopy | study_record | in vitro Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006885 SMASH-BIO | force_spectroscopy | study_record | in vitro Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006908 SMASH-BIO | force_spectroscopy | study_record | in vitro Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin alphaIIB beta3. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006945 SMASH-BIO | force_spectroscopy | study_record | in vitro Atomic force microscopy measurements of protein-ligand interactions on living cells. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007012 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanical unfolding intermediates observed by single-molecule force spectroscopy in a fibronectin type III module. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-007023 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular mechanics and dynamics of leukocyte recruitment during inflammation. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007026 SMASH-BIO | force_spectroscopy | study_record | in vitro Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007050-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 600 nN | in vitro Quantitative measurement of changes in adhesion force involving focal adhesion kinase during cell attachment, spread, and migration. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007141 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-induced focal adhesion translocation: effects of force amplitude and frequency. · Integrin; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007143 SMASH-BIO | force_spectroscopy | study_record | in vitro Functional and structural correlations of individual alphaIIbbeta3 molecules. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007156 SMASH-BIO | force_spectroscopy | study_record | in vitro Microviscoelasticity of the apical cell surface of human umbilical vein endothelial cells (HUVEC) within confluent monolayers. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007158 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction. · Integrin; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007258 SMASH-BIO | force_spectroscopy | study_record | in vitro Force measurements of the alpha5beta1 integrin-fibronectin interaction. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007259 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. · Integrin; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007261 SMASH-BIO | force_spectroscopy | study_record | in vitro Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007282 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular characterization of dendritic cells operating at the interface of innate or acquired immunity. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007298 SMASH-BIO | force_spectroscopy | study_record | in vitro Quantitative analysis of platelet alpha v beta 3 binding to osteopontin using laser tweezers. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007332 SMASH-BIO | force_spectroscopy | study_record | in vitro Binding strength and activation state of single fibrinogen-integrin pairs on living cells. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007345 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynamic force spectroscopy to probe adhesion strength of living cells. · Integrin; micropipette; experiment class: membrane_mechanics, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007361 SMASH-BIO | force_spectroscopy | study_record | in vitro In vitro studies on endometrial adhesiveness for trophoblast: cellular dynamics in uterine epithelial cells. · Integrin; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007446 SMASH-BIO | force_spectroscopy | study_record | in vitro Receptor-based differences in human aortic smooth muscle cell membrane stiffness. · Integrin; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007536 SMASH-BIO | force_spectroscopy | study_record | in vitro 3D single-particle tracking and optical trap measurements on adhesion proteins. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007689 SMASH-BIO | force_spectroscopy | study_record | in vitro Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated. · Integrin; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, translation_transcription_replication | unmapped |
Conflicts
No conflicts found among comparable evidence.
265 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.