Lupus La protein
UniProt P05455 · gene SSB · Homo sapiens · 408 residues
27evidence items
0mapped to a state
0states
6techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 27 of 27 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 6 | 0 |
| DisProt | 1 | 0 |
| RCSB PDB | 11 | 0 |
| SMASH-BIO | 8 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1OWX-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7 Solution structure of the C-terminal RRM of human La (La225-334) · Lupus La protein (chains A) | unmapped |
| EV-PDB-1S79-1 RCSB PDB | nmr_structure | structure | in vitro · 19.85 °C · pH 6 Solution structure of the central RRM of human La protein · Lupus La protein (chains A) | unmapped |
| EV-PDB-1YTY-2 RCSB PDB | xray | resolution: 2.29 Å | in vitro · -173.15 °C · pH 4.6 Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen · Lupus La protein (chains A,B) | unmapped |
| EV-PDB-1ZH5-2 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 4.6 · ligands SO4 Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen · Lupus La protein (chains A,B) | unmapped |
| EV-PDB-2VON-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU · LUPUS LA PROTEIN (chains A,B) | unmapped |
| EV-PDB-2VOP-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · ligands SO4 Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU · LUPUS LA PROTEIN (chains A) | unmapped |
| EV-PDB-9NF8-2 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro Cryo-EM structure of Ro60/La/truncated misfolded human pre-5S rRNA complex with Fab, composite map · Lupus La protein (chains B) | unmapped |
| EV-PDB-9NFA-2 RCSB PDB | cryoem | resolution: 2.7 Å | in vitro · ligands MG Cryo-EM structure of Ro60/La/minimal misfolded pre-5S rRNA complex with Fab, composite map · Lupus La protein (chains B) | unmapped |
| EV-PDB-2VOO-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU · LUPUS LA PROTEIN (chains A,B) | unmapped |
| EV-PDB-2VOD-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 5 Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU · LUPUS LA PROTEIN (chains A,B) | unmapped |
| EV-PDB-1S7A-1 RCSB PDB | nmr_structure | structure | in vitro · 19.85 °C · pH 7 NMR structure of the La motif of human La protein · Lupus La protein (chains A) | unmapped |
| EV-BMRB-15726 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 7 Backbone 1H, 13C, and 15N Chemical Shift Assignments for La NTD · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15727 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 7 Full 1H, 13C, and 15N Chemical Shift Assignments for La NTD complexed with 5'UUUU RNA · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17878 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.25 Backbone 1H, 13C, and 15N Chemical Shift Assignments for La(4-325) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-5235 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 7 Resonance assignment and secondary structure determination of a C-terminal fragment of the Lupus Autoantigen (La) protein containing a putative RNA recognition motif (RRM) · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-5719 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 6 Resonance assignment and secondary structure of an N-terminal fragment of the human La protein · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-6044 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 7 Resonance assignment and secondary structure of the La motif · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-DISPROT-DP00229r001 DisProt | nmr_shifts | disorder_region: 83 residues | in vitro DisProt DP00229: disorder, residues 326-408 · residues 326-408; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-AFDB-AF-P05455-F1 AlphaFold DB | af_prediction | plddt: 74.5 pLDDT | in silico AlphaFold DB prediction AF-P05455-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-408 | unmapped |
| EV-SMASH-SMFS-000004 SMASH-BIO | force_spectroscopy | study_record | in vitro A dedicated motif in human polymerase gamma enables DNA synthesis through replication roadblocks · SSB (E. coli); optical tweezers; experiment class: nucleic_acid_protein_interaction, translation_transcription_replication, unfolding_nucleic_acid, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001026 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8.1 "Helicase" Activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein. · SSB (E. coli); optical tweezers; experiment class: force_generation_motor, nucleic_acid_mechanics, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001228 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8.5 Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB. · SSB (E. coli); optical tweezers; experiment class: force_generation_polymerization, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001594 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB · SSB (E. coli); optical tweezers; experiment class: force_generation_polymerization, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001793 SMASH-BIO | force_spectroscopy | study_record | in vitro “Helicase” Activity Promoted Through Dynamic Interactions Between a ssDNA Translocase and a Diffusing SSB Protein · SSB (E. coli); optical tweezers; experiment class: force_generation_motor, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001995 SMASH-BIO | force_spectroscopy | study_record | in vitro Measurements of Real-Time Replication Kinetics of DNA Polymerases on ssDNA Templates Coated with Single-Stranded DNA-Binding Proteins. · SSB (E. coli); optical tweezers; experiment class: nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-002875 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8.5 Replicative DNA polymerases promote active displacement of SSB proteins during lagging strand synthesis. · SSB (E. coli); optical tweezers; experiment class: nucleic_acid_mechanics, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-005959 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Torsional regulation of hRPA-induced unwinding of double-stranded DNA. · SSB (E. coli); magnetic tweezers; experiment class: nucleic_acid_mechanics, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
Conflicts
No conflicts found among comparable evidence.
27 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.