Amyloid-beta precursor protein
UniProt P05067 · gene APP · Homo sapiens · 770 residues
380evidence items
0mapped to a state
0states
12techniques
7sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | microed | nmr_structure | nmr_dynamics | nmr_shifts | saxs_sans | cd | force_spectroscopy | integrative | af_prediction | md | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||||||||
Unmapped evidence: 380 of 380 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 52 | 0 |
| DisProt | 5 | 0 |
| MDDB | 6 | 0 |
| RCSB PDB | 271 | 0 |
| SASBDB | 7 | 0 |
| SMASH-BIO | 38 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-12GB-1 RCSB PDB | nmr_structure | structure | in vitro · 3.85 °C · pH 7.4 High Resolution Structure of Monomorphic AB1-40 Fibrils · Type IIIb beta-amyloid 40 Filament (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T) | unmapped |
| EV-PDB-1AAP-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR · ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN (chains A,B) | unmapped |
| EV-PDB-1QCM-1 RCSB PDB | nmr_structure | structure | in vitro AMYLOID BETA PEPTIDE (25-35), NMR, 20 STRUCTURES · AMYLOID BETA PEPTIDE (chains A) | unmapped |
| EV-PDB-1TAW-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 3.85 °C · pH 6.5 · ligands CA BOVINE TRYPSIN COMPLEXED TO APPI · PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR (chains B) | unmapped |
| EV-PDB-1TKN-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 6.4 Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-1X11-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7.5 X11 PTB DOMAIN · 13-MER PEPTIDE (chains C,D) | unmapped |
| EV-PDB-1Z0Q-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42) · Alzheimer's disease amyloid (chains A) | unmapped |
| EV-PDB-2BP4-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 3 Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution · AMYLOID BETA A4 PROTEIN (chains A) | unmapped |
| EV-PDB-2IPU-3 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -160.15 °C · pH 8.5 · ligands ACM, GOL PFA1 Fab fragment complexed with Abeta 1-8 peptide · abeta 1-8 peptide (chains P,Q) | unmapped |
| EV-PDB-2LFM-1 RCSB PDB | nmr_structure | structure | in vitro · -258.15 °C · pH 7.3 A partially folded structure of amyloid-beta(1 40) in an aqueous environment · Beta-amyloid protein 40 (chains A) | unmapped |
| EV-PDB-2LMQ-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Negative Stagger · Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R) | unmapped |
| EV-PDB-2LNQ-1 RCSB PDB | nmr_structure | structure | in vitro · 5.85 °C · pH 7.4 40-residue D23N beta amyloid fibril · P3(40) (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-2LMP-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Positive Stagger · Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R) | unmapped |
| EV-PDB-2LMO-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Negative Stagger · Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-2LMN-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Positive Stagger · Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-2LLM-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 4.6 Structure of amyloid precursor protein's transmembrane domain · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-2G47-2 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 7 · ligands DIO Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40) · amyloid protein beta A4 (chains C,D) | unmapped |
| EV-PDB-2FMA-1 RCSB PDB | xray | resolution: 0.85 Å | in vitro · -173.15 °C · pH 8 · ligands GOL Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution · Amyloid beta A4 protein precursor (chains A) | unmapped |
| EV-PDB-2FKL-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 21.85 °C · pH 4.05 Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP) · Amyloid beta A4 protein precursor (chains A,B) | unmapped |
| EV-PDB-2FK3-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 5.4 · ligands CU Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form · Amyloid beta A4 protein precursor (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-2FK2-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8 · ligands CU1 Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound · Amyloid beta A4 protein precursor (chains A) | unmapped |
| EV-PDB-2FK1-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8 · ligands CU Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(II)-bound · Amyloid beta A4 protein precursor (chains A) | unmapped |
| EV-PDB-2FJZ-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -168.15 °C · pH 8 Structure of the Alzheimer's Amyloid Precursor Protein (APP) copper binding domain (residues 133 to 189) in 'small unit cell' form, metal-free · Amyloid beta A4 protein precursor (chains A) | unmapped |
| EV-PDB-2BEG-1 RCSB PDB | nmr_structure | structure | in vitro 3D Structure of Alzheimer's Abeta(1-42) fibrils · Amyloid beta A4 protein (chains A,B,C,D,E) | unmapped |
| EV-PDB-23WO-2 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro · ligands ZN Cryo-EM structure of the de novo designed metalloprotease DP221 E85Q mutant · Amyloid-beta protein 42 (chains B) | unmapped |
| EV-PDB-23WN-2 RCSB PDB | cryoem | resolution: 2.98 Å | in vitro · ligands ZN Cryo-EM structure of the de novo designed metalloprotease DP622 E96Q mutant · Amyloid-beta protein 42 (chains B) | unmapped |
| EV-PDB-23WM-2 RCSB PDB | cryoem | resolution: 3.13 Å | in vitro · ligands ZN Cryo-EM structure of the de novo designed metalloprotease PP507 E110Q mutant · Amyloid-beta protein 42 (chains B) | unmapped |
| EV-PDB-21FB-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro Structure of minor species of Abeta fibrils from AppNL-FPsen1P117L mice · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-1ZJD-2 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -150.15 °C Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II · Kunitz Protease Inhibitory Domain of Protease Nexin II (chains B) | unmapped |
| EV-PDB-1ZE9-1 RCSB PDB | nmr_structure | structure | in vitro · 4.85 °C · pH 6.5 · ligands ZN Zinc-binding domain of Alzheimer's disease amyloid beta-peptide complexed with a zinc (II) cation · 16-mer from Alzheimer's disease amyloid Protein (chains A) | unmapped |
| EV-PDB-1ZE7-1 RCSB PDB | nmr_structure | structure | in vitro · 4.85 °C · pH 6.5 Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in water solution at pH 6.5 · 16-mer from Alzheimer's disease amyloid Protein (chains A) | unmapped |
| EV-PDB-1QYT-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 4.15 Solution structure of fragment (25-35) of beta amyloid peptide in SDS micellar solution · 11-mer peptide from Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-1QXC-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 4.5 NMR structure of the fragment 25-35 of beta amyloid peptide in 20/80 v:v hexafluoroisopropanol/water mixture · 11-mer peptide from Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-1QWP-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 4.5 NMR analysis of 25-35 fragment of beta amyloid peptide · 11-mer peptide from Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-1OWT-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.9 Structure of the Alzheimer's disease amyloid precursor protein copper binding domain · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-1MWP-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7.5 N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN · AMYLOID A4 PROTEIN (chains A) | unmapped |
| EV-PDB-1IYT-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42) · Alzheimer's disease amyloid (chains A) | unmapped |
| EV-PDB-1HZ3-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 5.6 ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35) · A-BETA AMYLOID (chains A) | unmapped |
| EV-PDB-1CA0-4 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 4.5 BOVINE CHYMOTRYPSIN COMPLEXED TO APPI · PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR (chains D,I) | unmapped |
| EV-PDB-1BRC-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN · AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI) (chains I) | unmapped |
| EV-PDB-1BJC-1 RCSB PDB | nmr_structure | structure | in vitro · 22.85 °C · pH 5.8 SOLUTION NMR STRUCTURE OF AMYLOID BETA[F16], RESIDUES 1-28, 15 STRUCTURES · AMYLOID BETA-PEPTIDE (chains A) | unmapped |
| EV-PDB-1BJB-1 RCSB PDB | nmr_structure | structure | in vitro · 22.85 °C · pH 5.6 SOLUTION NMR STRUCTURE OF AMYLOID BETA[E16], RESIDUES 1-28, 14 STRUCTURES · AMYLOID BETA-PEPTIDE (chains A) | unmapped |
| EV-PDB-1BA6-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 5.3 SOLUTION STRUCTURE OF THE METHIONINE-OXIDIZED AMYLOID BETA-PEPTIDE (1-40). DOES OXIDATION AFFECT CONFORMATIONAL SWITCHING? NMR, 10 STRUCTURES · AMYLOID BETA-PEPTIDE (chains A) | unmapped |
| EV-PDB-1BA4-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 5.1 THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES · AMYLOID BETA-PEPTIDE (chains A) | unmapped |
| EV-PDB-1AML-1 RCSB PDB | nmr_structure | structure | in vitro THE ALZHEIMER`S DISEASE AMYLOID A4 PEPTIDE (RESIDUES 1-40) · AMYLOID A4 (chains A) | unmapped |
| EV-PDB-1AMC-1 RCSB PDB | nmr_structure | structure | in vitro SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE · AMYLOID BETA-PEPTIDE (chains A) | unmapped |
| EV-PDB-1AMB-1 RCSB PDB | nmr_structure | structure | in vitro SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE · AMYLOID BETA-PEPTIDE (chains A) | unmapped |
| EV-PDB-11EP-1 RCSB PDB | cryoem | resolution: 2.75 Å | in vitro Structure of Rapidly twisting Amyloid-beta 40 fibril , RT-Ab40(C1) · RT-Ab40(C1) (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-11EO-1 RCSB PDB | cryoem | resolution: 2.73 Å | in vitro Structure of Rapidly twisting Amyloid-beta 40 fibril , RT-Ab40(C2) · RT-Ab40(C2) (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-11EN-1 RCSB PDB | cryoem | resolution: 2.5 Å | in vitro Structure of Rapidly twisting Amyloid-beta 40 fibril , RT-Ab40(2_1) · RT-Ab40(2_1) (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-2R0W-3 RCSB PDB | xray | resolution: 2.503 Å | in vitro · -173.15 °C · pH 5.3 · ligands NA PFA2 FAB complexed with Abeta1-8 · Amyloid beta peptide fragment (chains Q) | unmapped |
| EV-PDB-2WK3-2 RCSB PDB | xray | resolution: 2.59 Å | in vitro · -173.15 °C · ligands ZN Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) · BETA-AMYLOID PROTEIN 42 (chains C,D) | unmapped |
| EV-PDB-3GCI-2 RCSB PDB | xray | resolution: 2.04 Å | in vitro · 26.85 °C · pH 6 · ligands CA Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution · Heptapeptide from Amyloid beta A4 protein (chains P) | unmapped |
| EV-PDB-3KTM-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 5 · ligands ACT, BU4, SO4 Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) · Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-3L33-2 RCSB PDB | xray | resolution: 2.48 Å | in vitro · ligands CA, FMT Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI) · Amyloid beta A4 protein (chains E,F,G,H) | unmapped |
| EV-PDB-3L81-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7 · ligands GOL Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP) · Amyloid beta A4 protein (chains B) | unmapped |
| EV-PDB-3NYJ-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · pH 5.6 · ligands OS Crystal Structure Analysis of APP E2 domain · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-3NYL-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 4.5 The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain · Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b (chains A) | unmapped |
| EV-PDB-3SV1-2 RCSB PDB | xray | resolution: 3.3 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of APP peptide bound rat Mint2 PARM · Amyloid beta A4 protein (chains D,E,F) | unmapped |
| EV-PDB-3U0T-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C Fab-antibody complex · Amyloid beta A4 protein (chains E,F) | unmapped |
| EV-PDB-3Q2X-1 RCSB PDB | xray | resolution: 1.451 Å | in vitro · -173.15 °C Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-3PZZ-1 RCSB PDB | xray | resolution: 1.29 Å | in vitro · -173.15 °C Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta · Amyloid beta A4 protein (chains A,B) | unmapped |
| EV-PDB-3OW9-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C Structure of an amyloid forming peptide KLVFFA from amyloid beta, alternate polymorph II · KLVFFA hexapeptide segment from Amyloid beta (chains A,B) | unmapped |
| EV-PDB-3OVJ-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands ORA Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G · KLVFFA hexapeptide segment from Amyloid beta (chains A,B,C,D) | unmapped |
| EV-PDB-3MXY-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. · AICD peptide E683V variant (chains L) | unmapped |
| EV-PDB-3MXC-2 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. · AICD peptide (chains L) | unmapped |
| EV-PDB-3MOQ-1 RCSB PDB | xray | resolution: 2.054 Å | in vitro · -173.15 °C · pH 6 Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks · New antigen receptor variable domain,P3(40) peptide from Amyloid beta A4 protein,New antigen receptor variable domain (chains A,B,C,D) | unmapped |
| EV-PDB-3JTI-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 24.85 °C · pH 6 · ligands CA Crystal structure of the complex formed between Phospholipase A2 with beta-amyloid fragment, Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met at 1.8 A resolution · octapeptide from Amyloid beta A4 protein (chains B) | unmapped |
| EV-PDB-3JQL-2 RCSB PDB | xray | resolution: 1.2 Å | in vitro · 26.85 °C · pH 6 · ligands CA Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution · Amyloid Beta Peptide (chains B) | unmapped |
| EV-PDB-3JQ5-2 RCSB PDB | xray | resolution: 2.03 Å | in vitro · 26.85 °C · pH 6 · ligands CA Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution · Amyloid Beta Peptide (chains B) | unmapped |
| EV-PDB-3IFP-3 RCSB PDB | xray | resolution: 2.95 Å | in vitro · -173.15 °C · pH 7 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex · Amyloid beta A4 protein (chains P,Q,R,S) | unmapped |
| EV-PDB-3IFO-3 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · pH 7.5 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex · Amyloid beta A4 protein (chains P,Q) | unmapped |
| EV-PDB-3IFN-3 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 7.5 X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex · Amyloid beta A4 protein (chains P) | unmapped |
| EV-PDB-3IFL-3 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 9 X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex · Amyloid beta A4 protein (chains P) | unmapped |
| EV-PDB-3DXE-2 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 4.6 Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2 · Amyloid beta A4 protein (chains B,D) | unmapped |
| EV-PDB-3DXD-2 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 4.6 Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2 · Amyloid beta A4 protein (chains B,D) | unmapped |
| EV-PDB-3DXC-2 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 4.6 Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2 · Amyloid beta A4 protein (chains B,D) | unmapped |
| EV-PDB-3BKJ-3 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16) · Amyloid Beta Peptide (chains A) | unmapped |
| EV-PDB-3BAE-3 RCSB PDB | xray | resolution: 1.593 Å | in vitro · -173.15 °C · pH 9 Crystal structure of Fab WO2 bound to the N terminal domain of Amyloid beta peptide (1-28) · Amyloid Beta Peptide (chains A) | unmapped |
| EV-PDB-3AYU-2 RCSB PDB | xray | resolution: 2 Å | in vitro · ligands CA, ZN Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor · Amyloid beta A4 protein (chains B) | unmapped |
| EV-PDB-31VO-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands EDO, NAG Crystal structure of amyloid beta 1-15 fragment bound to HLA-DR1 · Amyloid-beta protein 40,HLA class II histocompatibility antigen, DRB1 beta chain (chains B,D) | unmapped |
| EV-PDB-2Y3L-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 7.5 Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2 · AMYLOID BETA A4 PROTEIN (chains A,B,C,G) | unmapped |
| EV-PDB-2Y3K-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 5.6 Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 1 · AMYLOID BETA A4 PROTEIN (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-2Y3J-1 RCSB PDB | xray | resolution: 1.99 Å | in vitro · -173.15 °C · pH 7 Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35) · AMYLOID BETA A4 PROTEIN (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-2Y2A-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 5.5 · ligands ACT Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I · AMYLOID BETA A4 PROTEIN (chains A) | unmapped |
| EV-PDB-2Y29-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 8.5 Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III · AMYLOID BETA A4 PROTEIN (chains A) | unmapped |
| EV-PDB-2OTK-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.2 Structure of Alzheimer Ab peptide in complex with an engineered binding protein · Amyloid beta A4 protein (chains C) | unmapped |
| EV-PDB-2NAO-1 RCSB PDB | nmr_structure | structure | in vitro · 3.85 °C · pH 7.4 Atomic resolution structure of a disease-relevant Abeta(1-42) amyloid fibril · Beta-amyloid protein 42 (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-2MXU-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 7.4 42-Residue Beta Amyloid Fibril · Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-2MVX-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 7 Atomic-resolution 3D structure of amyloid-beta fibrils: the Osaka mutation · Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-2MPZ-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.4 Atomic model of the Abeta D23N "Iowa" mutant using solid-state NMR, EM and Rosetta modeling · Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a) | unmapped |
| EV-PDB-2MJ1-1 RCSB PDB | nmr_structure | structure | in vitro · 4.85 °C · pH 7 NMR structure of the soluble A beta 17-34 peptide · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-2MGT-1 RCSB PDB | nmr_structure | structure | in vitro · 0.85 °C · pH 6.8 · ligands ZN Zinc induced dimer of the metal binding domain 1-16 of human amyloid beta-peptide with Alzheimer's disease pathogenic English mutation H6R · Amyloid beta A4 protein (chains A,B) | unmapped |
| EV-PDB-2M9S-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · ligands 23Y 3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-2M9R-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · ligands 23Y 3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-2M4J-1 RCSB PDB | nmr_structure | structure | in vitro · 14.85 °C · pH 7.4 40-residue beta-amyloid fibril derived from Alzheimer's disease brain · Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I) | unmapped |
| EV-PDB-2LZ4-1 RCSB PDB | nmr_structure | structure | in vitro · 39.85 °C · pH 7.2 Solution NMR structure of transmembrane domain of amyloid precursor protein V44M · Amyloid beta A4 protein (chains A,B) | unmapped |
| EV-PDB-2LZ3-1 RCSB PDB | nmr_structure | structure | in vitro · 39.85 °C · pH 7.2 Solution NMR structure of transmembrane domain of amyloid precursor protein WT · Amyloid beta A4 protein (chains A,B) | unmapped |
| EV-PDB-2LP1-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 6.5 The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99) · C99 (chains A) | unmapped |
| EV-PDB-2LOH-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 6.2 Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment · P3(42) (chains A,B) | unmapped |
| EV-PDB-3UMH-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.4 · ligands ACT, CD X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-3UMI-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 6.4 · ligands ACT, CD, ZN X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-3UMK-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 6.4 · ligands ACT, CD, CU X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-4HIX-3 RCSB PDB | xray | resolution: 2.204 Å | in vitro · -173.15 °C Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide · Beta-amyloid protein 40 (chains A) | unmapped |
| EV-PDB-4JFN-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 7.5 · ligands CU, GOL Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-4M1C-4 RCSB PDB | xray | resolution: 3.5007 Å | in vitro · pH 6.5 · ligands ZN Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) · Amyloid beta A4 protein (chains G,H) | unmapped |
| EV-PDB-4MDR-2 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 7 Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP) · Amyloid beta A4 protein (chains B) | unmapped |
| EV-PDB-4MVI-2 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 5.25 Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40) · Beta-amyloid protein 40 (chains B) | unmapped |
| EV-PDB-4MVK-2 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 6.5 Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED · Amyloid peptide fragment VFFAED (chains B) | unmapped |
| EV-PDB-4MVL-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 8 Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40 · Beta-amyloid protein 40 (chains E,F,G,H) | unmapped |
| EV-PDB-4NGE-2 RCSB PDB | xray | resolution: 2.704 Å | in vitro · -159.65 °C · pH 6.5 · ligands ACT, GOL, ZN Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40) · Beta-amyloid protein 40 (chains B,E) | unmapped |
| EV-PDB-4OJF-3 RCSB PDB | xray | resolution: 1.998 Å | in vitro · -173.15 °C · pH 7.5 Humanised 3D6 Fab complexed to amyloid beta 1-8 · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-4ONF-3 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 9 Fab fragment of 3D6 in complex with amyloid beta 1-7 · Amyloid beta A4 protein (chains P) | unmapped |
| EV-PDB-4ONG-3 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 8 · ligands CL, IMD, ZN Fab fragment of 3D6 in complex with amyloid beta 1-40 · Amyloid beta A4 protein (chains P) | unmapped |
| EV-PDB-4PQD-1 RCSB PDB | xray | resolution: 1.332 Å | in vitro · -173.15 °C · pH 7 The longer crystal structure of the grow factor like domain from Beta amypoid precusor protein (APP22-126) · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-4PWQ-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 5.6 HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN of THE AMYLOID PRECURSOR PROTEIN · Amyloid beta A4 protein (chains A,B) | unmapped |
| EV-PDB-4XXD-3 RCSB PDB | xray | resolution: 2.41 Å | in vitro · -173.15 °C · pH 4 Crystal Structure of mid-region amyloid beta capture by solanezumab · Amyloid-beta fragment (chains C,F) | unmapped |
| EV-PDB-5AEF-1 RCSB PDB | cryoem | resolution: 5 Å | in vitro Electron cryo-microscopy of an Abeta(1-42)amyloid fibril · AMYLOID BETA A4 PROTEIN (chains A,B) | unmapped |
| EV-PDB-5AM8-2 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8.5 · ligands CL, NAG, P6G, PEG, SO4, ZN, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 4-10 · BETA-AMYLOID PROTEIN 42 (chains P,Q,R,S) | unmapped |
| EV-PDB-5AMB-2 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 8.5 · ligands CL, P6G, PEG, PG4, ZN, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 35-42 · AMYLOID BETA A4 PROTEIN (chains P,Q) | unmapped |
| EV-PDB-5BUO-1 RCSB PDB | xray | resolution: 2.31 Å | in vitro · -173.15 °C · ligands ACT, CA, GOL, MG, SCN, SO4, ZN, branched: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose A receptor molecule · Amyloid beta A4 protein (chains A,B) | unmapped |
| EV-PDB-5C67-2 RCSB PDB | xray | resolution: 1.83 Å | in vitro · -173.15 °C · pH 7.5 Human Mesotrypsin in complex with amyloid precursor protein inhibitor variant APPI-M17G/I18F/F34V · Amyloid beta A4 protein (chains C,E) | unmapped |
| EV-PDB-5CSZ-3 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands NAG, SO4 CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11 · Amyloid beta A4 protein (chains D,E) | unmapped |
| EV-PDB-5HOW-1 RCSB PDB | xray | resolution: 2.295 Å | in vitro · -140.15 °C · pH 6.4 X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V · Amyloid beta A4 protein (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-5HOX-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7.1 · ligands JEF X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV). · Amyloid beta A4 protein (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-5HOY-1 RCSB PDB | xray | resolution: 2.295 Å | in vitro · -140.15 °C · pH 6.9 · ligands JEF X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV). · Amyloid beta A4 protein (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-5KK3-1 RCSB PDB | nmr_structure | structure | in vitro · 3.85 °C · pH 8 Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils · Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R) | unmapped |
| EV-PDB-5LFY-1 RCSB PDB | nmr_structure | structure | in vitro · 4.85 °C · pH 7 · ligands ZN Zinc bound dimer of the fragment of human amyloid-beta peptide with Alzheimer's disease pathogenic Taiwanese mutation D7H · Amyloid beta A4 protein (chains A,B) | unmapped |
| EV-PDB-5LV0-2 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 6.5 · ligands CL, ZN Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product · GLY-VAL-VAL amyloid 35-40 fragment (chains C,D) | unmapped |
| EV-PDB-5MY4-3 RCSB PDB | xray | resolution: 2.211 Å | in vitro · -173.15 °C · pH 5.5 Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb · Pyroglutamate-Abeta pE3-12-PEGb (chains C) | unmapped |
| EV-PDB-5MYO-3 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C · ligands GOL, SO4 Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb · Amyloid beta A4 protein (chains E) | unmapped |
| EV-PDB-5MYX-3 RCSB PDB | xray | resolution: 1.492 Å | in vitro · -173.15 °C · pH 5.5 Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18 · Pyroglutamate-Abeta pE3-18 (chains E,F) | unmapped |
| EV-PDB-5NX1-2 RCSB PDB | xray | resolution: 1.853 Å | in vitro · -173.15 °C Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy · Amyloid-beta A4 protein (chains B) | unmapped |
| EV-PDB-5NX1-3 RCSB PDB | xray | resolution: 1.853 Å | in vitro · -173.15 °C Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy · Amyloid-beta A4 protein (chains D) | unmapped |
| EV-PDB-5NX1-4 RCSB PDB | xray | resolution: 1.853 Å | in vitro · -173.15 °C Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy · Amyloid-beta A4 protein (chains C) | unmapped |
| EV-PDB-5NX3-2 RCSB PDB | xray | resolution: 2.296 Å | in vitro · -173.15 °C Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy · Amyloid-beta A4 protein (chains B) | unmapped |
| EV-PDB-5NX3-3 RCSB PDB | xray | resolution: 2.296 Å | in vitro · -173.15 °C Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy · Amyloid-beta A4 protein (chains D) | unmapped |
| EV-PDB-5NX3-4 RCSB PDB | xray | resolution: 2.296 Å | in vitro · -173.15 °C Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy · Amyloid-beta A4 protein (chains C) | unmapped |
| EV-PDB-5ONP-2 RCSB PDB | xray | resolution: 1.34 Å | in vitro · -173.15 °C · pH 6 · ligands CA, CD, DMS Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin · Amyloid-beta A4 protein (chains B) | unmapped |
| EV-PDB-5ONQ-2 RCSB PDB | xray | resolution: 1.17 Å | in vitro · -173.15 °C · pH 6 · ligands CA, CD, DMS Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin · Amyloid-beta A4 protein (chains B) | unmapped |
| EV-PDB-5ONR-2 RCSB PDB | xray | resolution: 1.39 Å | in vitro · -173.15 °C · pH 6 · ligands CA, DMS, ZN Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin · Amyloid-beta A4 protein (chains B) | unmapped |
| EV-PDB-5OQV-1 RCSB PDB | cryoem | resolution: 4 Å | in vitro Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM · Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I) | unmapped |
| EV-PDB-5TXD-1 RCSB PDB | xray | resolution: 1.452 Å | in vitro · -173.15 °C · pH 5 · ligands PO4 Structure of amyloid-beta derived peptide - NKGAIF · Amyloid beta A4 protein (chains Z) | unmapped |
| EV-PDB-5VOS-1 RCSB PDB | microed | resolution: 1.42 Å | in vitro · -173.15 °C · pH 4 VGSNKGAIIGL from Amyloid Beta determined by MicroED · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-5VZY-3 RCSB PDB | xray | resolution: 2.32 Å | in vitro · -180.15 °C Crystal structure of crenezumab Fab in complex with Abeta · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-5W3P-3 RCSB PDB | xray | resolution: 1.92 Å | in vitro · -173.15 °C · pH 4.5 · ligands GOL, SO4 ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16 · Amyloid beta A4 protein (chains P) | unmapped |
| EV-PDB-6CO3-3 RCSB PDB | xray | resolution: 2.384 Å | in vitro · -173.15 °C · pH 7 · ligands SO4 aducanumab abeta complex · ALA-GLU-PHE-ARG-HIS-ASP (chains Q) | unmapped |
| EV-PDB-6GFI-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · ligands EDO Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V · Amyloid-beta A4 protein (chains C,E) | unmapped |
| EV-PDB-6ITU-2 RCSB PDB | xray | resolution: 2.17 Å | in vitro · -163.15 °C · pH 3.3 · ligands EDO, SO4 Crystal Structure of the GULP1 PTB domain-APP peptide complex · Amyloid beta A4 protein (chains B) | unmapped |
| EV-PDB-6IYC-5 RCSB PDB | cryoem | resolution: 2.6 Å | in vitro · ligands CLR, NAG, PC1, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Recognition of the Amyloid Precursor Protein by Human gamma-secretase · Amyloid-beta A4 protein (chains E) | unmapped |
| EV-PDB-6NB9-1 RCSB PDB | microed | resolution: 1.05 Å | in vitro · -173.15 °C · pH 7.6 Amyloid-Beta (20-34) with L-isoaspartate 23 · Amyloid-beta A4 protein (chains A) | unmapped |
| EV-PDB-6O4J-1 RCSB PDB | microed | resolution: 1.402 Å | in vitro Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation · Amyloid-beta precursor protein (chains A,B) | unmapped |
| EV-PDB-6OC9-1 RCSB PDB | nmr_structure | structure | in vitro · 6.85 °C · pH 7.4 · ligands 2PO S8 phosphorylated beta amyloid 40 fibrils · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-6OIZ-1 RCSB PDB | microed | resolution: 1.1 Å | in vitro Amyloid-Beta (20-34) wild type · Amyloid beta A4 protein (chains A) | unmapped |
| EV-PDB-6RHY-1 RCSB PDB | nmr_structure | structure | in vitro · 37 °C · pH 8.5 Structure of pore-forming amyloid-beta tetramers · Amyloid beta A4 protein (chains A,B,C,D) | unmapped |
| EV-PDB-6XOV-2 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro CryoEM structure of human presequence protease in partial closed state 1 · Amyloid-beta precursor protein (chains B) | unmapped |
| EV-PDB-6YHX-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP I45T mutant TMD · Amyloid-beta precursor protein I45T mutant (chains A) | unmapped |
| EV-PDB-7B3J-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.9 Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55) · Isoform L-APP677 of Amyloid-beta precursor protein (chains A) | unmapped |
| EV-PDB-7JXO-1 RCSB PDB | xray | resolution: 2.81 Å | in vitro · -150 °C Triangular trimer of beta-hairpins derived from Abeta17-36 with an F20Cha mutation · Amyloid-beta 17-36 peptide (chains A,B,C) | unmapped |
| EV-PDB-8B9R-1 RCSB PDB | nmr_structure | structure | in vitro · 7.85 °C · pH 7.2 · ligands CU Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease · Amyloid-beta A4 protein (chains A) | unmapped |
| EV-PDB-8BFZ-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 · Amyloid-beta precursor protein (chains A,B) | unmapped |
| EV-PDB-8H8Q-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7.2 · ligands CL, NA Fab-amyloid beta fragment complex at neutral pH · GLN-LYS-CYS-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-CYS-GLY (chains A) | unmapped |
| EV-PDB-8KEW-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro The cryo-EM structure of type1 amyloid beta 42 fibril. · P3(40) (chains A,B,C,D,F,G) | unmapped |
| EV-PDB-8KF4-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient. · Amyloid-beta precursor protein (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-8KF3-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro The cryo-EM structure of type3 amyloid beta 42 fibril. · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I) | unmapped |
| EV-PDB-8KF1-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands VW6 The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril. · P3(40) (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-8I4O-2 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -163.15 °C Design of a split green fluorescent protein for sensing and tracking an beta-amyloid · Beta-amyloid (chains B,D,F,H,J,L) | unmapped |
| EV-PDB-8FF3-1 RCSB PDB | cryoem | resolution: 3.09 Å | in vitro Amyloid-beta (1-40) fibrils derived from familial Dutch-type CAA patient (population B) · Amyloid-beta precursor protein (chains A,B,C,a,b,c) | unmapped |
| EV-PDB-8FF2-1 RCSB PDB | cryoem | resolution: 2.87 Å | in vitro Amyloid-beta (1-40) fibrils derived from a CAA patient · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,I,J,K) | unmapped |
| EV-PDB-8EZE-1 RCSB PDB | cryoem | resolution: 2.76 Å | in vitro Brain-derived 42-residue amyloid-beta fibril type B · Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-8EZD-1 RCSB PDB | cryoem | resolution: 2.83 Å | in vitro Brain-derived 42-residue amyloid-beta fibril type A · Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-8C3H-2 RCSB PDB | xray | resolution: 1.71 Å | in vitro · -173.15 °C · ligands ZN Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex a long aspartimide degron peptide · P3(40) (chains D,E) | unmapped |
| EV-PDB-8BG0-1 RCSB PDB | cryoem | resolution: 1.99 Å | in vitro Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 · Amyloid-beta precursor protein (chains A,B,C,D) | unmapped |
| EV-PDB-8BFB-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice) · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8BFA-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8B9Q-1 RCSB PDB | nmr_structure | structure | in vitro · 7.85 °C · pH 7.2 · ligands CU Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease · Amyloid-beta A4 protein (chains A) | unmapped |
| EV-PDB-8AZT-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 · Amyloid-beta precursor protein (chains B) | unmapped |
| EV-PDB-8AZS-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro Type I amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 · Amyloid-beta precursor protein (chains H) | unmapped |
| EV-PDB-7Y8Q-1 RCSB PDB | nmr_structure | structure | in vitro · 14.85 °C · pH 7.4 Amyloid-beta assemblage on GM1-containing membranes · Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-7Y3J-3 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C 24B3 antibody-peptide complex · ALA-LEU-VAL-PHE-PHE-ALA-PRO-ASP-VAL-GLY-SER (chains A) | unmapped |
| EV-PDB-7WVY-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 · Amyloid-beta A4 protein (chains L) | unmapped |
| EV-PDB-7WFY-2 RCSB PDB | xray | resolution: 2.449 Å | in vitro · -173.15 °C · pH 8.4 Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide · Amyloid beta A4 protein-binding family B member 1 (protein) (chains A) | unmapped |
| EV-PDB-7U4P-1 RCSB PDB | xray | resolution: 1.803 Å | in vitro · -160.15 °C Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins · Amyloid-beta 17-36 peptide (chains A,B,C) | unmapped |
| EV-PDB-7RTZ-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -150.15 °C · ligands CL X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 14-40 · Amyloid-beta protein 40 (chains A,B) | unmapped |
| EV-PDB-7Q4M-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro · ligands UNX Type II beta-amyloid 42 Filaments from Human Brain · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-7Q4B-1 RCSB PDB | cryoem | resolution: 2.5 Å | in vitro · ligands UNX Type I beta-amyloid 42 Filaments from Human Brain · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,R) | unmapped |
| EV-PDB-7OXN-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7 · ligands EDO, ZN Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide · Amyloid-beta precursor protein (chains A) | unmapped |
| EV-PDB-7OW1-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands FLC Crystal Structure of TAP01 in complex with amyloid beta peptide · Amyloid-beta precursor protein (chains A) | unmapped |
| EV-PDB-7O1Q-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro Amyloid beta oligomer displayed on the alpha hemolysin scaffold · Alpha-hemolysin hybridized Abeta (chains A,B,C,D,E,F,G) | unmapped |
| EV-PDB-7JXN-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -150 °C · ligands CL, NA Beta hairpin derived from Abeta17-36 with an F20Cha mutation · Amyloid-beta 17-36 peptide (chains A,B,C,D) | unmapped |
| EV-PDB-7F29-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands ACY, branched: beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42) · Amyloid-beta A4 protein (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-7E6P-3 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · ligands EDO, PEG Fab-amyloid beta fragment complex · Amyloid beta fragment with an intramolecular disulfide bond at positions 17 and 28 (chains A) | unmapped |
| EV-PDB-7B3K-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.9 Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55) · Isoform L-APP677 of Amyloid-beta precursor protein (chains A) | unmapped |
| EV-PDB-6YHP-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP V44M mutant TMD · Amyloid-beta precursor protein V44M mutant (chains A) | unmapped |
| EV-PDB-6YHO-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP G38P mutant TM · Amyloid-beta precursor protein G38P mutant (chains A) | unmapped |
| EV-PDB-6YHI-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP G38L mutant TMD · Amyloid-beta precursor protein G38L mutant (chains A) | unmapped |
| EV-PDB-6YHF-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP TMD · Amyloid-beta precursor protein (chains A) | unmapped |
| EV-PDB-6WXM-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -160 °C · pH 5 · ligands HEZ X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 16-36 · Amyloid-beta protein (chains A,B,C,D,E,F,G,H,I,J,K) | unmapped |
| EV-PDB-6W0O-1 RCSB PDB | cryoem | resolution: 2.77 Å | in vitro · 23.85 °C · pH 7.4 Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue · Amyloid-beta precursor protein (chains 1,2,3,4,5,6) | unmapped |
| EV-PDB-6TI7-2 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 8.5 Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils · Amyloid-beta precursor protein (chains B,D,F,H,I,K,M,O) | unmapped |
| EV-PDB-6TI7-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 8.5 Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils · Amyloid-beta precursor protein (chains A,C,E,G,J,L,N,P) | unmapped |
| EV-PDB-6TI6-2 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 8.5 Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils · Amyloid-beta precursor protein (chains B,D,F,H,J,L,N,P) | unmapped |
| EV-PDB-6TI6-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 8.5 Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils · Amyloid-beta precursor protein (chains A,C,E,G,I,K,M,O) | unmapped |
| EV-PDB-6TI5-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 8.5 A New Structural Model of Abeta(1-40) Fibrils · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P) | unmapped |
| EV-PDB-6SZF-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 5.4 Solution structure of the amyloid beta-peptide (1-42) · Amyloid-beta precursor protein (chains A) | unmapped |
| EV-PDB-6SHS-1 RCSB PDB | cryoem | resolution: 4.4 Å | in vitro Abeta fibril (Morphology I) · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-8OL3-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro Murine type III Abeta fibril from APP/PS1 mouse · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OT1-1 RCSB PDB | cryoem | resolution: 2.59 Å | in vitro unseeded Abeta(1-40) amyloid fibril (morphology i) · Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-8OT3-1 RCSB PDB | cryoem | resolution: 2.73 Å | in vitro unseeded Abeta(1-40) amyloid fibril (morphology ii) · Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-8OT4-1 RCSB PDB | cryoem | resolution: 2.97 Å | in vitro seeded Abeta(1-40) amyloid fibril (morphology I) · Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-8OTF-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro Ab typeII filament from Guam ALS/PDC · Amyloid-beta precursor protein (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-8OVK-1 RCSB PDB | cryoem | resolution: 2.88 Å | in vitro Lipidic amyloid-beta(1-40) fibril - polymorph L1 · Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OVM-1 RCSB PDB | cryoem | resolution: 3.24 Å | in vitro Lipidic amyloid-beta(1-40) fibril - polymorph L2 · Amyloid-beta A4 protein (chains A,B,C,D,E) | unmapped |
| EV-PDB-8OWD-1 RCSB PDB | cryoem | resolution: 3.28 Å | in vitro Lipidic amyloid-beta(1-40) fibril - polymorph L3 · Amyloid-beta A4 protein (chains A,B,C,D,E) | unmapped |
| EV-PDB-8OWE-1 RCSB PDB | cryoem | resolution: 3.75 Å | in vitro Lipidic amyloid-beta(1-40) fibril - polymorph L2-L3 · Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OWJ-1 RCSB PDB | cryoem | resolution: 3.75 Å | in vitro Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2 · Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OWK-1 RCSB PDB | cryoem | resolution: 3.86 Å | in vitro Lipidic amyloid-beta(1-40) fibril - polymorph L3-L3 · Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8QN6-1 RCSB PDB | cryoem | resolution: 2.4 Å | in vitro Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy · Amyloid-beta A4 protein (chains A,F) | unmapped |
| EV-PDB-8QN7-1 RCSB PDB | cryoem | resolution: 2.7 Å | in vitro Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy · Amyloid-beta A4 protein (chains A) | unmapped |
| EV-PDB-8SEK-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro Type IIIa beta-amyloid 40 Filaments from Down syndrome · Type IIIb beta-amyloid 40 Filament (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8T82-1 RCSB PDB | xray | resolution: 1.1 Å | in vitro · -173.15 °C · ligands YWK Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes pentafluoropropionic acid · amyloid beta segment 35-MVGGVV-40, racemic mixture (chains A) | unmapped |
| EV-PDB-8T89-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands TFA Racemic mixture of amyloid beta segment 16-KLVFFA-21 forms heterochiral rippled beta-sheet · Racemic mixture of amyloid beta segment 16-KLVFFA-21 (chains A) | unmapped |
| EV-PDB-8X52-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands CLR, NAG, PC1, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of human gamma-secretase in complex with Abeta49 · Amyloid-beta precursor protein (chains E) | unmapped |
| EV-PDB-8X54-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands CLR, NAG, PC1, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of human gamma-secretase in complex with APP-C99 · Amyloid-beta precursor protein (chains E) | unmapped |
| EV-PDB-8Z9V-1 RCSB PDB | cryoem | resolution: 7.84 Å | in vitro Amyloid beta and TTR · Amyloid-beta protein 42 (chains e) | unmapped |
| EV-PDB-9A8F-1 RCSB PDB | integrative | structure | in vitro Type II Amyloid beta Fibril MEMMI ensemble · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X) | unmapped |
| EV-PDB-9CK6-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro Cryo-EM structure of sarkosyl insoluble amyloid-beta 42 filaments extracted from human brain tissue · Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,R) | unmapped |
| EV-PDB-9CKI-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro Cryo-EM structure of the poly(4-styrenesulfonic acid-co-maleic acid) [PSCMA]-extractable amyloid-beta 42 oligomer from human brain tissue (Conformation 2) · Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9CZN-1 RCSB PDB | cryoem | resolution: 2.6 Å | in vitro Type Ic amyloid-beta 42 filaments in dominantly inherited Alzheimer disease with cotton wool plaques · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T) | unmapped |
| EV-PDB-9CZP-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro Type Id amyloid-beta 42 filaments in dominantly inherited Alzheimer disease with cotton wool plaques · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T) | unmapped |
| EV-PDB-9FH3-1 RCSB PDB | cryoem | resolution: 3.9 Å | in vitro Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 2 · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9FH4-1 RCSB PDB | cryoem | resolution: 4 Å | in vitro Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 3 · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9FH5-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 4 · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T) | unmapped |
| EV-PDB-9IIO-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro J-shaped conformer of amyloid beta (1-40) · Amyloid-beta protein 40 (chains 2,3,4,5,6,A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f,g,h,i) | unmapped |
| EV-PDB-9JAZ-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro Cryo-EM structure of the class I amyloid-beta 42 fibril containing a D-Asp at position 23 · Amyloid-beta precursor protein (chains A,AA,B,BB,C,CC,D,DD,E,EE,F,FF) | unmapped |
| EV-PDB-9JB1-1 RCSB PDB | cryoem | resolution: 2.5 Å | in vitro Cryo-EM structure of the type I amyloid-beta 42 fibril containing a D-Asp at positions 7 and 23 · Amyloid-beta precursor protein (chains FF,FG,FH,FI,FJ,FK,FL,FM,FN,FO,FP,FQ) | unmapped |
| EV-PDB-9K0D-2 RCSB PDB | cryoem | resolution: 2.6 Å | in vitro Cryo-EM structure of Amyloid-beta42-4b polymorph 1 · Amyloid-beta protein 40 (chains B,F,K,L,S,T) | unmapped |
| EV-PDB-9K0E-2 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro Cryo-EM structure of Amyloid-beta42-4b polymorph 2 · Amyloid-beta protein 40 (chains A,D,E,F,L,M) | unmapped |
| EV-PDB-9JB2-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro Cryo-EM structure of the type II amyloid-beta 42 fibril containing a D-Asp at positions 7 and 23 · Amyloid-beta precursor protein (chains A,B,BA,BB,BC,BD,BE,C,CA,CB,CC,CD,CE,D,E) | unmapped |
| EV-PDB-9JB0-1 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro Cryo-EM structure of the class II amyloid-beta 42 fibril containing a D-Asp at position 23 · Amyloid-beta precursor protein (chains A,AA,B,BB,C,CC,D,DD,E,EE,F,FF) | unmapped |
| EV-PDB-9FH2-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 1 · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9CO4-1 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro Cryo-EM structure of the receptor-bound amyloid-beta 42 oligomer from human brain tissue (Conformation 1) · Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9A8E-1 RCSB PDB | integrative | structure | in vitro Type I Amyloid beta Fibril MEMMI ensemble · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X) | unmapped |
| EV-PDB-8X53-5 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands CLR, NAG, PC1, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of human gamma-secretase in complex with Abeta46 · Amyloid-beta precursor protein (chains E) | unmapped |
| EV-PDB-8SEL-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro Type IIIb beta-amyloid 40 Filaments from Down Syndrome · Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T) | unmapped |
| EV-PDB-8SEJ-1 RCSB PDB | cryoem | resolution: 3.17 Å | in vitro Type I beta-amyloid 42 Filaments from Down syndrome · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OLQ-1 RCSB PDB | cryoem | resolution: 4 Å | in vitro DI3 Abeta fibril from tg-SwDI mouse · Amyloid-beta protein 42 (chains A,B,C,D,E) | unmapped |
| EV-PDB-8OLO-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro Murine type III Abeta fibril from ARTE10 mouse · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OLN-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro DI1 Abeta fibril from tg-SwDI mouse · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OLG-1 RCSB PDB | cryoem | resolution: 4.2 Å | in vitro DI2 Abeta fibril from tg-SwDI mouse · Amyloid-beta protein 42 (chains A,B,C,D,E) | unmapped |
| EV-PDB-8OL7-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro MurineArc type I Abeta fibril from tg-APPArcSwe mouse · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OL6-1 RCSB PDB | cryoem | resolution: 3.8 Å | in vitro Murine type II Abeta fibril from tgAPPSwe mouse · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OL5-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro Murine type II Abeta fibril from ARTE10 mouse · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8OL2-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro Murine type II Abeta fibril from APP23 mouse · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-8KF6-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro The cryo-EM structure of AV-45 bound type3 amyloid beta 42 fibril. · P3(40) (chains A,B,C,D,E,F,G,H,I) | unmapped |
| EV-PDB-8KF5-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro The cryo-EM structure of type1 amyloid beta 42 fibril in AD3. · Amyloid-beta precursor protein (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-9WTW-1 RCSB PDB | cryoem | resolution: 1.98 Å | in vitro Amyloid-beta 40 Flemish (A21G) mutant Filaments from Human Brain · Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9WAP-1 RCSB PDB | cryoem | resolution: 3.22 Å | in vitro Structure of Type II Abeta fibrils from AppNL-FPsen1P117L mice · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-9WAO-1 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro Structure of type II Abeta fibrils from 5xFAD mice · Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L) | unmapped |
| EV-PDB-9W0Z-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro The cryo-EM structure of Apo_type1 abeta fibril. · Amyloid-beta precursor protein (chains Y,Z,a,b,c,d) | unmapped |
| EV-PDB-9VXE-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands A1EUE The cryo-EM structure of NapIM_type1 amyloid beta 42 fibril. · Amyloid-beta precursor protein (chains R,S,T,U,V,W,X,Y,Z,a,b,c) | unmapped |
| EV-PDB-9UMH-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro V-type (V2-type) amyloid fibril (40) of Tottori (D7N) mutant · Amyloid-beta protein 40 (chains AL,AM,AN,AO,AP,AQ,AR,AS,AT,AU,AV,AW,AX,AY,AZ,Aa,Ab,Ac,Ad,Ae,Af) | unmapped |
| EV-PDB-9RIW-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro Population A fibril generated from the Heterotypic interaction of Abeta40 and Medin. · Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-9RIV-1 RCSB PDB | cryoem | resolution: 2.63 Å | in vitro Population B fibril generated from the Heterotypic interaction of Abeta40 and Medin. · Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9ONC-1 RCSB PDB | cryoem | resolution: 3.64 Å | in vitro A-beta42-Met-R-SO amyloidal fibril - class3 · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9OBK-1 RCSB PDB | cryoem | resolution: 3.01 Å | in vitro A-beta42-Met-R-SO amyloidal fibril · Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J) | unmapped |
| EV-PDB-9M5R-1 RCSB PDB | cryoem | resolution: 3.6 Å | in vitro ES-type (short pitch) amyloid fibril (40) of Tottori (D7N) mutant · Amyloid-beta protein 40 (chains 0,1,2,3,4,5,6,7,8,9,A,A0,A1,A2,A3,A4,A5,A6,A7,A8,A9,AA,AB,AC,AD,AE,AF,AG,AH,AI,AJ,AK,AL,AM,AN,AO,AP,AQ,AR,AS,AT,AU,AV,AW,AX,AY,AZ,Aa,Ab,Ac,Ad,Ae,Af,Ag,Ah,Ai,Aj,Ak,Al,Am,An,Ao,Ap,Aq,Ar,As,At,Au,Av,Aw,Ax,Ay,Az,B,BA,BB,BC,BD,BE,BF,BG,BH,BI,BJ,BK,BL,BM,BN,BO,BP,BQ,BR,BS,BT,BU,BV,BW,BX,BY,BZ,Ba,Bb,Bc,Bd,Be,Bf,Bg,Bh,Bi,Bj,Bk,Bl,Bm,Bn,Bo,Bp,Bq,Br,Bs,Bt,Bu,Bv,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f,g,h,i,j,k,l,m,n,o,p,q,r,s,t,u,v,w,x,y,z) | unmapped |
| EV-PDB-9M5Q-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro V-type (V1-type) amyloid fibril (40) of Tottori (D7N) mutant · Amyloid-beta protein 40 (chains AL,AM,AN,AO,AP,AQ,AR,AS,AT,AU,AV,AW,AX,AY,AZ,Aa,Ab,Ac,Ad,Ae,Af) | unmapped |
| EV-PDB-9M5P-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro I-type amyloid fibril (40) of Tottori (D7N) mutant · Amyloid-beta protein 40 (chains 1,2,3,4,5,6) | unmapped |
| EV-PDB-9LLM-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 5.2 Structure of C-Terminal of AB40 Peptide containing GXXXG Motif in SDS Micelles · P3(40) (chains A) | unmapped |
| EV-PDB-9K0F-2 RCSB PDB | cryoem | resolution: 2.8 Å | in vitro Cryo-EM structure of Amyloid-beta42-4b polymorph 3 · Amyloid-beta protein 40 (chains K,N,O) | unmapped |
| EV-BMRB-10236 BMRB | nmr_shifts | chemical_shift | in vitro · 22.85 °C · pH 7 Structure of the C-terminal PID Domain of Fe65L1 Complexed with the Cytoplasmic Tail of APP Reveals a Novel Peptide Binding Mode · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-11435 BMRB | nmr_shifts | chemical_shift | in vitro · 3.85 °C · pH 6.5 1H, 13C, and 15N Chemical Shift Assignments for amyloid-beta-(1-40) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15775 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 6.5 Backbone chemical shift assignment for the transmembrane and C-terminal domains of amyloid precursor protein (APP C99) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17159 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.4 Backbone assignment of the affibody-bound amyloid B-peptide · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17764 BMRB | nmr_shifts | chemical_shift | in vitro · 14.85 °C · pH 7.3 A partially folded structure of amyloid-beta(1 40) in an aqueous environment · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-17793 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7.2 Backbone chemical shift assignments for Ab42 with Met35 in its oxidized state · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17794 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7.2 Backbone chemical shift assignments for Ab42 with Met35 in its reduced state · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17795 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7.2 Backbone chemical shift assignments for A 40 with Met35 in its oxidised state · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17796 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7.2 Backbone chemical shift assignments for A 40 with Met35 in its reduced state · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18052 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 2.8 Structural analysis of the pyroglutamate modified isoform of the Alzheimer's disease related beta-amyloid using NMR spectroscopy · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-18080 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 4.6 structure of amyloid precursor protein's transmembrane domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18127 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Positive Stagger · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-18128 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Negative Stagger · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-18129 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Positive Stagger · BMRB data: 13C chemical shifts | unmapped |
| EV-BMRB-18131 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 7.4 Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Negative Stagger · BMRB data: 13C chemical shifts | unmapped |
| EV-BMRB-18649 BMRB | nmr_shifts | chemical_shift | in vitro · 39.85 °C · pH 7.2 Transmembrane domain of Amyloid precursor protein WT · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-19309 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C 3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-19393 BMRB | nmr_shifts | chemical_shift | in vitro · 6.85 °C · pH 7 Solid-state NMR sequential assignment of Osaka-Mutant Amyloid-beta (A 1-40 E22 ) fibrils · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-19701 BMRB | nmr_shifts | chemical_shift | in vitro · 4.85 °C · pH 7 NMR structure of the soluble A 17-34 peptide · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-2024 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Sequential NMR Resonance Assignment and Structure Determination of the Kunitz-Type Inhibitor Domain of the Alzheimer's B-Amyloid Precursor Protein · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-25218 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7.4 Chemical shifts of amyloid beta (1-42) peptide in aqueous solution · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25289 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7 Atomic-resolution 3D structure of amyloid-beta fibrils: the Osaka mutation · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-25429 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 7.4 42-Residue Beta Amyloid Fibril · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-26508 BMRB | nmr_dynamics | relaxation_rate | in vitro · 2.85 °C · pH 7.4 Transient small molecule interactions kinetically modulate amyloid b peptide self-assembly · BMRB data: T2 relaxation values | unmapped |
| EV-BMRB-26516 BMRB | nmr_dynamics | relaxation_rate | in vitro · 2.85 °C · pH 7.4 Transient small molecule interactions kinetically modulate amyloid b peptide self-assembly · BMRB data: T2 relaxation values | unmapped |
| EV-BMRB-26692 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7.4 Solid State NMR sequential assignment of Amyloid b(1-42) fibrils · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-27212 BMRB | nmr_shifts | chemical_shift | in vitro · 4.85 °C · pH 2 Backbone 13C and 15N Chemical Shift Assignments for fibrillar Amyloid Beta (1-42) · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-30121 BMRB | nmr_shifts | chemical_shift | in vitro · 3.85 °C · pH 8 Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-30596 BMRB | nmr_shifts | chemical_shift | in vitro · 6.85 °C · pH 7.4 S8 phosphorylated beta amyloid 40 fibrils · BMRB data: 13C chemical shifts | unmapped |
| EV-BMRB-30731 BMRB | nmr_shifts | chemical_shift | in vitro · 23.85 °C · pH 7.4 Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-31300 BMRB | nmr_shifts | chemical_shift | in vitro · 3.85 °C · pH 7.4 High Resolution Structure of Monomorphic AB1-40 Fibrils · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34019 BMRB | nmr_shifts | chemical_shift | in vitro · 4.85 °C · pH 7 Zinc bound dimer of the fragment of human amyloid-beta peptide with Alzheimer's disease pathogenic Taiwanese mutation D7H · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34396 BMRB | nmr_shifts | chemical_shift | in vitro · 37 °C · pH 8.5 Structure of pore-forming amyloid-beta tetramers · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34440 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 5.4 Solution structure of the amyloid beta-peptide (1-42) · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-34454 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 8.5 A New Structural Model of Abeta(1-40) Fibrils · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-34455 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 8.5 Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-34456 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 8.5 Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-34506 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP TMD · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34507 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP TMD · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34508 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP G38P mutant TM · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34509 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP TMD V44M mutant · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34510 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Solution NMR Structure of APP TMD I45T mutant · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34762 BMRB | nmr_shifts | chemical_shift | in vitro · 7.85 °C · pH 7.2 Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34763 BMRB | nmr_shifts | chemical_shift | in vitro · 7.85 °C · pH 7.2 Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-5057 BMRB | nmr_shifts | chemical_shift | in vitro · 7.85 °C · pH 6.4 1H Chemical Shift Assignments for Alzheimer peptide Ab(1-40) · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-51321 BMRB | nmr_shifts | chemical_shift | in vitro · 5 °C · pH 2 Sequence-specific Backbone Resonance Assignments of Human Amyloid-beta(1-42) in 28% Acetonitrile at pH 2.0 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-51322 BMRB | nmr_shifts | chemical_shift | in vitro · 5 °C · pH 7 Sequence-specific Backbone Resonance Assignments of Human Amyloid-beta(1-42) at pH 7.0 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-51323 BMRB | nmr_shifts | chemical_shift | in vitro · 5 °C · pH 2 Sequence-specific Backbone Resonance Assignments of Human Amyloid-beta(1-42) at pH 2.0 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-51584 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 7 Backbone 13C and 15N Chemical Shift Assignments for fibrillar Amyloid Beta (1-42) at pH 7.0 · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-51993 BMRB | nmr_shifts | chemical_shift | in vitro · -10.15 °C · pH 2 Backbone 13C and 15N Chemical Shift Assignments for Fibrils of Pyroglutamate Amyloid beta (3-42) at pH 2 · BMRB data: 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-5400 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide abeta 1-42 by mirror image phage display · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-6236 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 6.4 Backbone 1H, 13C, and 15N Chemical Shift Assignments for CAPPD*, an Independently Folded Extracellular Domain of Human Amyloid-beta Precursor Protein · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-SASBDB-SASDKN3 SASBDB | saxs_sans | radius_of_gyration: 3.037 nm ± 0.24 | in vitro · 22 °C · pH 7.7 · ligands partner: Presequence protease, mitochondrial Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition · Amyloid-beta precursor protein with Presequence protease, mitochondrial | unmapped |
| EV-SASBDB-SASDPP7 SASBDB | saxs_sans | radius_of_gyration: 5.81 nm ± 0.151 | in vitro · 20 °C · pH 10.7 Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation · Amyloid-beta precursor protein | unmapped |
| EV-SASBDB-SASDPQ7 SASBDB | saxs_sans | radius_of_gyration: 6.863 nm ± 1.601 | in vitro · 20 °C · pH 10.7 Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation · Amyloid-beta precursor protein | unmapped |
| EV-SASBDB-SASDPR7 SASBDB | saxs_sans | radius_of_gyration: 2.5 nm ± 0.044 | in vitro · 20 °C · pH 10.7 Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation · Amyloid-beta precursor protein | unmapped |
| EV-SASBDB-SASDPS7 SASBDB | saxs_sans | radius_of_gyration: 3.73 nm ± 0.131 | in vitro · 20 °C · pH 10.7 Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation · Amyloid-beta precursor protein | unmapped |
| EV-SASBDB-SASDPT7 SASBDB | saxs_sans | radius_of_gyration: 3.73 nm ± 0.362 | in vitro · 20 °C · pH 10.7 Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation · Amyloid-beta precursor protein | unmapped |
| EV-SASBDB-SASDPU7 SASBDB | saxs_sans | radius_of_gyration: 3.504 nm ± 0.114 | in vitro · 20 °C · pH 10.7 Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation · Amyloid-beta precursor protein | unmapped |
| EV-DISPROT-DP01280r001 DisProt | cd | disorder_region: 40 residues | in vitro DisProt DP01280: disorder, residues 672-711 · residues 672-711; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01280r003 DisProt | cd | disorder_region: 40 residues | in vitro DisProt DP01280: disorder to order, residues 672-711 · residues 672-711; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01280r004 DisProt | nmr_shifts | disorder_region: 15 residues | in vitro DisProt DP01280: disorder, residues 672-686 · residues 672-686; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01280r005 DisProt | cd | disorder_region: 40 residues | in vitro DisProt DP01280: disorder, residues 672-711 · residues 672-711; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP01280r009 DisProt | nmr_shifts | disorder_region: 40 residues | in vitro DisProt DP01280: disorder, residues 672-711 · residues 672-711; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-AFDB-AF-P05067-F1 AlphaFold DB | af_prediction | plddt: 67.38 pLDDT | in silico AlphaFold DB prediction AF-P05067-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-770 | unmapped |
| EV-MDDB-A002Z MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1AMB · start 1AMB; Amber Parm99 | unmapped |
| EV-MDDB-A003S MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1AAP · start 1AAP; Amber Parm99 | unmapped |
| EV-MDDB-A0061 MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1BRC · start 1BRC; Amber Parm99 | unmapped |
| EV-MDDB-A00AE MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1CA0 · start 1CA0; Amber Parm99 | unmapped |
| EV-MDDB-A00PF MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1MWP · start 1MWP; Amber Parm99 | unmapped |
| EV-MDDB-A011T MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1TAW · start 1TAW; Amber Parm99 | unmapped |
| EV-SMASH-SMFS-000021 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Amyloid β-Cholesterol Interplay: Removal of Cholesterol From the Membranes to Catalyze Aggregation and Amyloid Pathology. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000030 SMASH-BIO | force_spectroscopy | study_record | in vitro Aβ42 Adopts a Stronger Binding Affinity to the Gold Surface than Aβ40. · Amyloid-β; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000379 SMASH-BIO | force_spectroscopy | study_record | in vitro Amyloid β interaction with membranes: Removal of cholesterol from the membranes to catalyze aggregation and amyloid pathology · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000540 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Nucleation dynamics in amyloid-beta dimerization revealed by single-molecule fingerprinting. · Amyloid-β; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000661 SMASH-BIO | force_spectroscopy | study_record | in vitro De novo design of a mechano-pharmaceutical screening platform against formation of individual beta-amyloid oligomers. · Amyloid-β; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-001675 SMASH-BIO | force_spectroscopy | study_record | in vitro Protein aggregation rate depends on mechanical stability of fibrillar structure. · Amyloid-β; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001876 SMASH-BIO | force_spectroscopy | study_record | in vitro Detection of Amyloid β Oligomers by a Fluorescence Ratio Strategy Based on Optically Trapped Highly Doped Upconversion Nanoparticles-SiO2@Metal-Organic Framework Microspheres. · Amyloid-β; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002226 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 AFM Probing of Amyloid-Beta 42 Dimers and Trimers. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002340 SMASH-BIO | force_spectroscopy | study_record | in vitro Exploring Interactions of Aptamers with Aβ40 Amyloid Aggregates and Its Application: Detection of Amyloid Aggregates. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002539 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule studies of amyloid proteins: from biophysical properties to diagnostic perspectives. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002637 SMASH-BIO | force_spectroscopy | study_record | in vitro Aptamer as a Tool for Investigating the Effects of Electric Field on Aβ40 Monomer and Aggregates Using Single-Molecule Force Spectroscopy. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002727 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Force clamp approach for characterization of nano-assembly in amyloid beta 42 dimer. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003231 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing Amyloid β and the Antibody Interaction Using Atomic Force Microscopy. · Amyloid-β; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003235-r0 SMASH-BIO | force_spectroscopy | rupture_force: 48 pN ± 2.4 | in vitro · pH 7.4 Probing Intermolecular Interactions within the Amyloid β Trimer Using a Tethered Polymer Nanoarray. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003235-r1 SMASH-BIO | force_spectroscopy | rupture_force: 53 pN ± 3.2 | in vitro · pH 7.4 Probing Intermolecular Interactions within the Amyloid β Trimer Using a Tethered Polymer Nanoarray. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003658 SMASH-BIO | force_spectroscopy | study_record | in vitro Pseudo-peptide amyloid-β blocking inhibitors: molecular dynamics and single molecule force spectroscopy study. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003723 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Single-molecule probing of amyloid nano-ensembles using the polymer nanoarray approach. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003800 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 A Metal-free Click Chemistry Approach for the Assembly and Probing of Biomolecules. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003818 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.1 Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons. · Amyloid-β; afm smfs; experiment class: membrane_mechanics, rheology_cell | unmapped |
| EV-SMASH-SMFS-003879 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer's Amyloid-β Peptides. · Amyloid-β; afm smfs; experiment class: nucleic_acid_protein_interaction, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004013 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Probing of Amyloid Aβ (14-23) Trimers by Single-Molecule Force Spectroscopy. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004117 SMASH-BIO | force_spectroscopy | study_record | in vitro A flexible nanoarray approach for the assembly and probing of molecular complexes. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004460 SMASH-BIO | force_spectroscopy | study_record | in vitro Amyloid-β (1-40) restores adhesion properties of pulmonary surfactant, counteracting the effect of cholesterol. · Amyloid-β; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004497 SMASH-BIO | force_spectroscopy | study_record | in vitro Comparison of three competing dynamic force spectroscopy models to study binding forces of amyloid-β (1-42). · Amyloid-β; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-004644 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Nanoprobing of misfolding and interactions of amyloid β 42 protein. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-004651 SMASH-BIO | force_spectroscopy | study_record | in vitro Oligomeric Amyloid-β Peptide on Sialylic Lewisx-Selectin Bonding at Cerebral Endothelial Surface. · Amyloid-β; afm smfs; experiment class: force_generation_polymerization, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004727 SMASH-BIO | force_spectroscopy | study_record | in vitro Testing synthetic amyloid-β aggregation inhibitor using single molecule atomic force spectroscopy. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-004738 SMASH-BIO | force_spectroscopy | study_record | in vitro The structure of misfolded amyloidogenic dimers: computational analysis of force spectroscopy data. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004828 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Cu(2+) affects amyloid-β (1-42) aggregation by increasing peptide-peptide binding forces. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004847 SMASH-BIO | force_spectroscopy | study_record | in vitro Dissecting the structural determinants for the difference in mechanical stability of silk and amyloid beta-sheet stacks. · Amyloid-β; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004932 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanism of amyloid β-protein dimerization determined using single-molecule AFM force spectroscopy. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-004949-r0 SMASH-BIO | force_spectroscopy | bond_lifetime: 1 s | in vitro · pH 7 Molecular mechanism of misfolding and aggregation of Aβ(13-23). · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-004961 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-004968 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Novel polymer linkers for single molecule AFM force spectroscopy. · Amyloid-β; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005487 SMASH-BIO | force_spectroscopy | study_record | in vitro Effect of the beta-sheet-breaker peptide LPFFD on oriented network of amyloid β25-35 fibrils. · Amyloid-β; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005585 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Nanoscale structural and mechanical effects of beta-amyloid (1-42) on polymer cushioned membranes: a combined study by neutron reflectometry and AFM Force Spectroscopy. · Amyloid-β; afm smfs; experiment class: membrane_mechanics | unmapped |
| EV-SMASH-SMFS-005647 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Single-molecule atomic force microscopy force spectroscopy study of Aβ-40 interactions. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-006222 SMASH-BIO | force_spectroscopy | study_record | in vitro Tau aggregation followed by atomic force microscopy and surface plasmon resonance, and single molecule tau-tau interaction probed by atomic force spectroscopy. · Amyloid-β; afm smfs; experiment class: unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
373 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.