Cellular tumor antigen p53
UniProt P04637 · gene TP53 · Homo sapiens · 393 residues
388evidence items
0mapped to a state
0states
11techniques
7sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | saxs_sans | cd | fluorescence | force_spectroscopy | integrative | af_prediction | md | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No states defined yet. | |||||||||||||
Unmapped evidence: 388 of 388 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 14 | 0 |
| DisProt | 27 | 0 |
| MDDB | 1 | 0 |
| RCSB PDB | 325 | 0 |
| SASBDB | 6 | 0 |
| SMASH-BIO | 14 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1A1U-1 RCSB PDB | nmr_structure | structure | in vitro · 39.85 °C · pH 7 SOLUTION STRUCTURE DETERMINATION OF A P53 MUTANT DIMERIZATION DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE · P53 (chains A,C) | unmapped |
| EV-PDB-1AIE-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · 19.85 °C · pH 8 P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE · P53 (chains A) | unmapped |
| EV-PDB-1C26-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 24.85 °C · pH 8.8 CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN · P53 TUMOR SUPPRESSOR (chains A) | unmapped |
| EV-PDB-1DT7-2 RCSB PDB | nmr_structure | structure | in vitro · 36.85 °C · pH 6.5 · ligands CA SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB) · CELLULAR TUMOR ANTIGEN P53 (chains X,Y) | unmapped |
| EV-PDB-1GZH-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 7.4 · ligands SO4, ZN Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor · CELLULAR TUMOR ANTIGEN P53 (chains A) | unmapped |
| EV-PDB-1GZH-3 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 7.4 · ligands SO4, ZN Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor · CELLULAR TUMOR ANTIGEN P53 (chains C) | unmapped |
| EV-PDB-1H26-3 RCSB PDB | xray | resolution: 2.24 Å | in vitro · -173.15 °C · pH 7 CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53 · CELLULAR TUMOR ANTIGEN P53 (chains E) | unmapped |
| EV-PDB-1HS5-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7 NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-1JSP-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 NMR Structure of CBP Bromodomain in complex with p53 peptide · tumor protein p53 (chains A) | unmapped |
| EV-PDB-1MA3-2 RCSB PDB | xray | resolution: 2 Å | in vitro · -180.15 °C · pH 5.5 · ligands MES, ZN Structure of a Sir2 enzyme bound to an acetylated p53 peptide · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-1OLH-1 RCSB PDB | nmr_structure | structure | in vitro HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR · TUMOR SUPPRESSOR P53 (OLIGOMERIZATION DOMAIN) (chains A,B,C,D) | unmapped |
| EV-PDB-1PES-1 RCSB PDB | nmr_structure | structure | in vitro NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53 · TUMOR SUPPRESSOR P53 (chains A,B,C,D) | unmapped |
| EV-PDB-1PET-1 RCSB PDB | nmr_structure | structure | in vitro NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53 · TUMOR SUPPRESSOR P53 (chains A,B,C,D) | unmapped |
| EV-PDB-1SAE-1 RCSB PDB | nmr_structure | structure | in vitro HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES) · TUMOR SUPPRESSOR P53 (chains A,B,C,D) | unmapped |
| EV-PDB-1SAF-1 RCSB PDB | nmr_structure | structure | in vitro HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES) · TUMOR SUPPRESSOR P53 (chains A,B,C,D) | unmapped |
| EV-PDB-1SAK-1 RCSB PDB | nmr_structure | structure | in vitro HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES) · TUMOR SUPPRESSOR P53 (chains A,B,C,D) | unmapped |
| EV-PDB-1SAL-1 RCSB PDB | nmr_structure | structure | in vitro HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES) · TUMOR SUPPRESSOR P53 (chains A,B,C,D) | unmapped |
| EV-PDB-1TSR-3 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -175.15 °C · ligands ZN P53 CORE DOMAIN IN COMPLEX WITH DNA · PROTEIN (P53 TUMOR SUPPRESSOR) (chains A,B,C) | unmapped |
| EV-PDB-1TUP-3 RCSB PDB | xray | resolution: 2.2 Å | in vitro · ligands ZN TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA · PROTEIN (P53 TUMOR SUPPRESSOR ) (chains A,B,C) | unmapped |
| EV-PDB-1UOL-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7.2 · ligands ZN Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution. · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-1XQH-2 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 7.8 · ligands SAH Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH · 9-mer peptide from tumor protein p53 (chains B,F) | unmapped |
| EV-PDB-1YC5-2 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -180.15 °C · pH 9.6 · ligands NCA, ZN Sir2-p53 peptide-nicotinamide · Cellular tumor antigen p53 peptide (chains B) | unmapped |
| EV-PDB-1YCQ-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53 · P53 (chains B) | unmapped |
| EV-PDB-1YCR-2 RCSB PDB | xray | resolution: 2.6 Å | in vitro MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53 · P53 (chains B) | unmapped |
| EV-PDB-1YCS-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · ligands ZN P53-53BP2 COMPLEX · P53 (chains A) | unmapped |
| EV-PDB-21EX-3 RCSB PDB | xray | resolution: 2.021 Å | in vitro · -173.15 °C Wild tipe p53WT-HLA-A2 · Cellular tumor antigen p53 (chains C) | unmapped |
| EV-PDB-2ADY-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 6.2 · ligands ZN Structural Basis of DNA Recognition by p53 Tetramers (complex IV) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-2AHI-2 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 6.3 · ligands ZN Structural Basis of DNA Recognition by p53 Tetramers (complex III) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-2ATA-2 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.7 · ligands ZN Structural Basis of DNA Recognition by p53 Tetramers (complex II) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-2B3G-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · pH 7.9 p53N (fragment 33-60) bound to RPA70N · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2BIM-1 RCSB PDB | xray | resolution: 1.98 Å | in vitro · -173.15 °C · ligands SO4, ZN human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2BIN-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands ZN human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D · CELLULAR TUMOR ANTIGEN P53 (chains A) | unmapped |
| EV-PDB-2BIO-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands ZN human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D · CELLULAR TUMOR ANTIGEN P53 (chains A) | unmapped |
| EV-PDB-2BIP-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands ZN human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D · CELLULAR TUMOR ANTIGEN P53 (chains A) | unmapped |
| EV-PDB-2BIQ-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands ZN human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D · CELLULAR TUMOR ANTIGEN P53 (chains A) | unmapped |
| EV-PDB-2FOJ-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8.5 The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367 · p53 peptide (chains B) | unmapped |
| EV-PDB-2FOO-2 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 8.5 The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362 · p53 peptide (chains B) | unmapped |
| EV-PDB-2GS0-2 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 6.5 NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53 · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2H1L-2 RCSB PDB | xray | resolution: 3.16 Å | in vitro · -73.15 °C · pH 6.5 · ligands ZN The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex · Cellular tumor antigen p53 (chains M,N,O,P,Q,R,S,T,U,V,W,X) | unmapped |
| EV-PDB-2H2D-2 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 9.6 · ligands ZN The Structural Basis for Sirtuin Substrate Affinity · Cellular tumor antigen p53 peptide (chains B) | unmapped |
| EV-PDB-2H4F-2 RCSB PDB | xray | resolution: 2 Å | in vitro · -195.79 °C · pH 9.6 · ligands NAD, ZN Sir2-p53 peptide-NAD+ · Cellular tumor antigen p53 (chains D) | unmapped |
| EV-PDB-2H4J-2 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 9.6 · ligands NCA, OAD, ZN Sir2-deacetylated peptide (from enzymatic turnover in crystal) · Cellular tumor antigen p53 (chains D) | unmapped |
| EV-PDB-2H59-2 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 5.2 · ligands 3OD, APR, ZN Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose · Cellular tumor antigen p53 (chains D,E) | unmapped |
| EV-PDB-2J0Z-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7.2 p53 tetramerization domain wild type · CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D) | unmapped |
| EV-PDB-2J10-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7.2 p53 tetramerization domain mutant T329F Q331K · CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D) | unmapped |
| EV-PDB-2H4H-2 RCSB PDB | xray | resolution: 1.99 Å | in vitro · -173.15 °C · pH 9.6 · ligands NAD, ZN Sir2 H116Y mutant-p53 peptide-NAD · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2H2F-2 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 9.6 · ligands ZN The Structural basis for Sirtuin Substrate affinity · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2FEJ-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.1 · ligands ZN Solution structure of human p53 DNA binding domain. · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-2AC0-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.6 · ligands ZN Structural Basis of DNA Recognition by p53 Tetramers (complex I) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-1OLG-1 RCSB PDB | nmr_structure | structure | in vitro HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR · TUMOR SUPPRESSOR P53 (OLIGOMERIZATION DOMAIN) (chains A,B,C,D) | unmapped |
| EV-PDB-1KZY-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -170.15 °C · pH 6 · ligands ZN Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2J11-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 7.2 p53 tetramerization domain mutant Y327S T329G Q331G · CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D) | unmapped |
| EV-PDB-2J1W-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands ZN Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2J1X-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · ligands ZN Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2J1Z-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands ZN Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2J20-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands SO4, ZN Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2J21-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · ligands ZN Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2K8F-2 RCSB PDB | nmr_structure | structure | in vitro · 34.85 °C · pH 6.3 Structural Basis for the Regulation of p53 Function by p300 · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2L14-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Structure of CBP nuclear coactivator binding domain in complex with p53 TAD · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2LY4-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2MWO-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.5 Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2PCX-1 RCSB PDB | xray | resolution: 1.54 Å | in vitro · -173.15 °C · pH 7.5 · ligands ZN Crystal structure of p53DBD(R282Q) at 1.54-angstrom Resolution · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-2V5W-3 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands K, ZN Crystal structure of HDAC8-substrate complex · PEPTIDIC SUBSTRATE (chains I,L) | unmapped |
| EV-PDB-2VUK-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 7.2 · ligands P83, ZN Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2WGX-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 7.2 · ligands ZN HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2X0U-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.2 · ligands X0U, ZN STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2X0V-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7.2 · ligands X0V, ZN STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2X0W-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands X0W, ZN STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2XWR-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · ligands ZN Crystal structure of the DNA-binding domain of human p53 with extended N terminus · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-2YBG-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands ZN Structure of Lys120-acetylated p53 core domain · CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D) | unmapped |
| EV-PDB-2Z5S-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -183.15 °C · pH 6.5 Molecular basis for the inhibition of p53 by Mdmx · Cellular tumor antigen p53 (chains P,Q,R) | unmapped |
| EV-PDB-2Z5T-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -183.15 °C · pH 6.5 Molecular basis for the inhibition of p53 by Mdmx · Cellular tumor antigen p53 (chains P,Q,R) | unmapped |
| EV-PDB-37ZA-1 RCSB PDB | xray | resolution: 2.11 Å | in vitro · -173.15 °C · ligands ZN Crystal structure of TP53 (89-293, Y220C) · Cellular tumor antigen p53 (chains AAA,BBB) | unmapped |
| EV-PDB-3D05-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Human p53 core domain with hot spot mutation R249S (II) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-3D06-1 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Human p53 core domain with hot spot mutation R249S (I) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-3D07-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Human p53 core domain with hot spot mutation R249S (III) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-3D08-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-3D09-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-3D0A-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-3DAB-2 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain · Cellular tumor antigen p53 (chains B,D,F,H) | unmapped |
| EV-PDB-3IGK-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 2) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-3IGL-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, ZN Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-3KMD-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · pH 6.68 · ligands ZN Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-3KZ8-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 6.1 · ligands IOD, ZN Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-3LW1-2 RCSB PDB | xray | resolution: 1.28 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, GOL, MG Binary complex of 14-3-3 sigma and p53 pT387-peptide · peptide of Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-3OQ5-2 RCSB PDB | xray | resolution: 2.5005 Å | in vitro · -173.15 °C · pH 4.8 Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1 · Cellular tumor antigen p53 (chains D,E) | unmapped |
| EV-PDB-3PDH-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 · ligands ZN Structure of Sir2Tm bound to a propionylated peptide · Cellular tumor antigen p53 18-residue peptide (chains D) | unmapped |
| EV-PDB-3Q01-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -188.15 °C · pH 7.5 · ligands ZN An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-3Q05-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -188.15 °C · pH 7 · ligands ZN An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-3Q06-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -188.15 °C · pH 7 · ligands ZN An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-3SAK-1 RCSB PDB | nmr_structure | structure | in vitro · 34.85 °C HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES) · PROTEIN (TUMOR SUPPRESSOR P53) (chains A,B,C,D) | unmapped |
| EV-PDB-3DAC-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.5 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain · Cellular tumor antigen p53 (chains B,P) | unmapped |
| EV-PDB-37ZR-1 RCSB PDB | xray | resolution: 2.39 Å | in vitro · -173.15 °C · ligands A1DRM, ZN Crystal structure of TP53 (89-293, Y220C) bound to compound 3 · Cellular tumor antigen p53 (chains AAA,BBB) | unmapped |
| EV-PDB-2YDR-2 RCSB PDB | xray | resolution: 2.75 Å | in vitro · -173.15 °C · pH 8.5 · ligands CD, NAG CpOGA D298N in complex with p53-derived O-GlcNAc peptide · CELLULAR TUMOR ANTIGEN P53 (chains P) | unmapped |
| EV-PDB-2RUK-1 RCSB PDB | nmr_structure | structure | in vitro · 31.85 °C · pH 6.8 Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-2OCJ-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 7.6 · ligands ZN Human p53 core domain in the absence of DNA · P53 TUMOR SUPPRESSOR (chains A,B,C,D) | unmapped |
| EV-PDB-2MZD-2 RCSB PDB | nmr_structure | structure | in vitro · 34.85 °C · pH 6.3 Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2MWY-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Mdmx-p53 · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2MWP-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.5 Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2MEJ-2 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 · ligands ZN Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-2J1Y-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · ligands CA, ZN Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D · CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D) | unmapped |
| EV-PDB-3TG5-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL, SAH, ZN Structure of SMYD2 in complex with p53 and SAH · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-3TS8-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -188.15 °C · pH 7 · ligands ZN Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-3ZME-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 7.2 · ligands QC5, ZN Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-4AGL-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands P84, ZN Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-4AGM-1 RCSB PDB | xray | resolution: 1.52 Å | in vitro · -173.15 °C · ligands P86, ZN Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-4AGN-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · ligands NXG, ZN Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5116 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-4AGO-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · ligands P74, ZN Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-4AGP-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands P51, ZN Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-4AGQ-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · ligands P96, ZN Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-4BUZ-2 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8.5 · ligands EDO, NAD, OAD, OCZ, ZN SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD · CELLULAR TUMOR ANTIGEN P53 (chains P) | unmapped |
| EV-PDB-4BV2-2 RCSB PDB | xray | resolution: 3.3 Å | in vitro · -173.15 °C · pH 5.9 · ligands OAD, OCZ, ZN CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE · CELLULAR TUMOR ANTIGEN P53 (chains E,H) | unmapped |
| EV-PDB-4FZ3-2 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 7.5 · ligands ZN Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin · peptide from Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-4HFZ-2 RCSB PDB | xray | resolution: 2.694 Å | in vitro · 22.85 °C · pH 7.4 · ligands SO4 Crystal Structure of an MDM2/P53 Peptide Complex · Cellular tumor antigen p53 (chains B,D) | unmapped |
| EV-PDB-4HJE-1 RCSB PDB | xray | resolution: 1.907 Å | in vitro · ligands ZN Crystal structure of p53 core domain in complex with DNA · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4IBQ-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.1 · ligands ACT, EDO, ZN Human p53 core domain with hot spot mutation R273C · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4IBS-1 RCSB PDB | xray | resolution: 1.78 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, ZN Human p53 core domain with hot spot mutation R273H (form I) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4IBT-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4IBU-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6.1 · ligands ACT, EDO, ZN Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R in sequence-specific complex with DNA · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4IBV-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, ZN Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-4IBW-1 RCSB PDB | xray | resolution: 1.791 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, ZN Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R in sequence-specific complex with DNA · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-4IBY-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, ZN Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation S240R · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-4IBZ-1 RCSB PDB | xray | resolution: 1.92 Å | in vitro · -173.15 °C · pH 6.1 · ligands ACT, EDO, ZN Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4IJT-1 RCSB PDB | xray | resolution: 1.78 Å | in vitro · -173.15 °C · pH 6.1 · ligands DTT, EDO, ZN Human p53 core domain with hot spot mutation R273H (form II) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-4KVP-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 7.6 · ligands ZN Human p53 Core Domain Mutant V157F · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4LO9-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 7 · ligands ZN Human p53 Core Domain Mutant N235K · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4LOE-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 7.6 · ligands ZN Human p53 Core Domain Mutant N239Y · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4LOF-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7.6 · ligands ZN Human p53 Core Domain Mutant V157F/N235K/N239Y · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-4MZI-1 RCSB PDB | xray | resolution: 1.25 Å | in vitro · -188.15 °C · pH 6.8 · ligands ZN Crystal structure of a human mutant p53 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-4MZR-1 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -188.15 °C · pH 7 · ligands ZN Crystal structure of a polypeptide p53 mutant bound to DNA · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-4QO1-2 RCSB PDB | xray | resolution: 1.924 Å | in vitro · -173.15 °C · pH 6.5 · ligands ZN p53 DNA binding domain in complex with Nb139 · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-4RP6-1 RCSB PDB | xray | resolution: 1.703 Å | in vitro · -173.15 °C · pH 8.5 Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258) · LTIITLE heptapeptide segment from p53 (chains Z) | unmapped |
| EV-PDB-4X34-2 RCSB PDB | xray | resolution: 1.801 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2 · THR-SER-ARG-HIS-ALY-MLY-LEU-MET-PHE-LYS (chains C,D) | unmapped |
| EV-PDB-4XR8-2 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · pH 6.5 · ligands EDO, PEG, ZN, branched: alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution · Cellular tumor antigen p53 (chains C,D) | unmapped |
| EV-PDB-4ZZJ-2 RCSB PDB | xray | resolution: 2.7403 Å | in vitro · -173.15 °C · ligands 4TQ, CNA, GOL, ZN SIRT1/Activator/Substrate Complex · Ac-p53 (chains B) | unmapped |
| EV-PDB-5A7B-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands KMN, ZN Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5AB9-1 RCSB PDB | xray | resolution: 1.36 Å | in vitro · -173.15 °C · ligands 92O, PEG, ZN Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5ABA-1 RCSB PDB | xray | resolution: 1.62 Å | in vitro · -173.15 °C · ligands UL7, ZN Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5AOI-1 RCSB PDB | xray | resolution: 1.78 Å | in vitro · -173.15 °C · ligands PEG, RZH, ZN Structure of the p53 cancer mutant Y220C in complex with an indole- based small molecule · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5AOJ-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · ligands PEG, Y0V, ZN Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5AOK-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · ligands GOH, GOL, PEG, ZN Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan7099 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5AOL-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands UFV, ZN Structure of the p53 cancer mutant Y220C with bound 3-bromo-5-(trifluoromethyl)benzene-1,2-diamine · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5AOM-1 RCSB PDB | xray | resolution: 1.74 Å | in vitro · -173.15 °C · ligands FY8, GOL, ZN Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5BUA-1 RCSB PDB | xray | resolution: 1.812 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Lysine 120-acetylated P53 DNA binding domain in a complex with DNA. · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-5G4M-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · ligands EDO, GOL, O82, ZN Crystal structure of the p53 cancer mutant Y220C in complex with a monofluorinated derivative of the small molecule stabilizer Phikan083 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5G4N-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · ligands GOL, O83, ZN Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5G4O-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · ligands O80, ZN Crystal structure of the p53 cancer mutant Y220C in complex with a trifluorinated derivative of the small molecule stabilizer Phikan083 · CELLULAR TUMOR ANTIGEN P53 (chains A,B) | unmapped |
| EV-PDB-5HOU-1 RCSB PDB | nmr_structure | structure | in vitro · 34.85 °C · pH 6.8 · ligands ZN Solution Structure of p53TAD-TAZ1 · Cellular tumor antigen p53,CREB-binding protein fusion protein (chains A) | unmapped |
| EV-PDB-5HP0-1 RCSB PDB | nmr_structure | structure | in vitro · 31.85 °C · pH 6.8 · ligands ZN Solution Structure of TAZ2-p53AD2 · CREB-binding protein,Cellular tumor antigen p53 fusion protein (chains A) | unmapped |
| EV-PDB-5ECG-1 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C · pH 6.5 · ligands ZN Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-4RP7-1 RCSB PDB | xray | resolution: 1.576 Å | in vitro · -173.15 °C · pH 6 · ligands ZN Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258) · TIITLE hexapeptide segment from p53 (chains Z) | unmapped |
| EV-PDB-5HPD-1 RCSB PDB | nmr_structure | structure | in vitro · 31.85 °C · pH 6.8 · ligands ZN Solution Structure of TAZ2-p53TAD · CREB-binding protein,Cellular tumor antigen p53 fusion protein (chains A) | unmapped |
| EV-PDB-5LGY-1 RCSB PDB | xray | resolution: 2.92 Å | in vitro · -173.15 °C · pH 6.1 · ligands ZN Lysine 120-acetylated P53 DNA binding domain in a complex with the BAX response element. · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-5MCV-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8.8 · ligands ACT, EDO, ZN New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC1) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5MCW-1 RCSB PDB | xray | resolution: 1.897 Å | in vitro · -173.15 °C · pH 8.8 · ligands FOR, ZN New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC2) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5MG7-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 7 · ligands ZN New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-p53R2) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5MHC-2 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · ligands CA, MG Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide · LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP (chains P) | unmapped |
| EV-PDB-5MOC-2 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands CL, MG Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide · p53 C-terminal domain (chains P) | unmapped |
| EV-PDB-5O1A-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · ligands 9H5, GOL, ZN p53 cancer mutant Y220C in complex with compound MB240 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1B-1 RCSB PDB | xray | resolution: 1.43 Å | in vitro · -173.15 °C · ligands 9H2, GOL, ZN p53 cancer mutant Y220C in complex with compound MB84 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1C-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · ligands 9GZ, ZN p53 cancer mutant Y220C in complex with compound MB184 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1D-1 RCSB PDB | xray | resolution: 1.36 Å | in vitro · -173.15 °C · ligands 9GW, GOL, ZN p53 cancer mutant Y220C in complex with compound MB481 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1E-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · ligands 9GT, GOL, ZN p53 cancer mutant Y220C im complex with compound MB577 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1F-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · ligands 9GQ, ZN p53 cancer mutant Y220C in complex with compound MB582 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1G-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · ligands 9GK, GOL, ZN p53 cancer mutant Y220C in complex with compound MB487 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1H-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · ligands 9GN, GOL, ZN p53 cancer mutant Y220C in complex with compound MB539 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5O1I-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands 9GH, EDO, GOL, ZN p53 cancer mutant Y220C in complex with compound MB710 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5UN8-2 RCSB PDB | xray | resolution: 2.13 Å | in vitro · -193.15 °C · ligands NAG Crystal Structure of human O-GlcNAcase in complex with glycopeptide p53 · P53 peptide (chains E,F,G,H) | unmapped |
| EV-PDB-5XZC-2 RCSB PDB | cryoem | resolution: 10.7 Å | in vitro Cryo-EM structure of p300-p53 protein complex · Cellular tumor antigen p53 (chains B,C,D,E) | unmapped |
| EV-PDB-6FF9-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands ZN Mutant R280K of human P53 · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-6GGA-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · ligands EY2, ZN p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9284 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6GGB-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · ligands EDO, EPE, EXQ, GOL, ZN p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9318 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6GGC-1 RCSB PDB | xray | resolution: 1.24 Å | in vitro · -173.15 °C · ligands EDO, EXN, GOL, ZN p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9320 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6GGD-1 RCSB PDB | xray | resolution: 1.40001 Å | in vitro · -173.15 °C · ligands EYB, GOL, ZN p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6GGE-1 RCSB PDB | xray | resolution: 1.25001 Å | in vitro · -173.15 °C · ligands EYE, ZN p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6GGF-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · ligands EXQ, GOL, ZN Structure of the p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9328 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6LHD-1 RCSB PDB | xray | resolution: 2.499 Å | in vitro · -173.15 °C · pH 7 · ligands ZN Crystal structure of p53/BCL-xL fusion complex · fusion protein of Bcl-2-like protein 1 and Isoform 6 of Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6R5L-2 RCSB PDB | xray | resolution: 1.884 Å | in vitro · -173.15 °C · ligands CL, GOL, JT2, MG Fragment AZ-006 binding at the p53pT387/14-3-3 sigma interface · p53pT387 (chains P) | unmapped |
| EV-PDB-6RJZ-2 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, GOL, K6B, MG Fragment AZ-015 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RKI-2 RCSB PDB | xray | resolution: 1.88 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, K6T, MG Fragment AZ-023 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RKM-2 RCSB PDB | xray | resolution: 1.88 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, GOL, K6Z, MG Fragment AZ-022 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RL3-2 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, GOL, K48, MG Fragment AZ-003 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RL4-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, K7N, MG Fragment AZ-025 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RL6-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, K7Q, MG Fragment AZ-024 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RM5-2 RCSB PDB | xray | resolution: 1.884 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, K8W, MG Fragment AZ-016 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RM7-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, K92, MG Fragment AZ-026 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RWH-2 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · ligands CA, KLB, MG Fragment AZ-007 binding at a primary and secondary binding site of the the p53pT387/14-3-3 sigma complex · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RWI-2 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, KLE, MG Fragment AZ-002 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RWS-2 RCSB PDB | xray | resolution: 1.53 Å | in vitro · -173.15 °C · pH 7.5 · ligands KLZ, MG Fragment AZ-009 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RWU-2 RCSB PDB | xray | resolution: 1.46 Å | in vitro · -173.15 °C · pH 7.5 · ligands KM8 Fragment AZ-010 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RX2-2 RCSB PDB | xray | resolution: 1.82 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, KM2, MG Fragment AZ-005 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RZ3-1 RCSB PDB | xray | resolution: 4.23 Å | in vitro · -173.15 °C · ligands ZN Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-6S39-2 RCSB PDB | xray | resolution: 1.88 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, K5Z Fragment AZ-018 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RKK-2 RCSB PDB | xray | resolution: 1.88 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, GOL, K6W, MG Fragment AZ-021 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6RK8-2 RCSB PDB | xray | resolution: 1.602 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, K6N, MG Fragment AZ-014 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6FJ5-1 RCSB PDB | xray | resolution: 2.051 Å | in vitro · -173.15 °C · pH 7 · ligands EDO, ZN New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-AGG-HG) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-5OL0-2 RCSB PDB | xray | resolution: 1.99 Å | in vitro · -173.15 °C · pH 7.5 · ligands ZN Structure of Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSIR2rp1) in complex with acetylated p53 peptide · Cellular tumor antigen p53 (chains C,D) | unmapped |
| EV-PDB-5MF7-1 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C · pH 8 · ligands PEG, ZN New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-GADD45) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5MCU-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7 · ligands EDO, ZN New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5MCT-1 RCSB PDB | xray | resolution: 1.446 Å | in vitro · -173.15 °C · pH 7 · ligands EDO, FOR, ZN New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG1) · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-5LAP-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · ligands 6SM, ZN p53 cancer mutant Y220C with Cys182 alkylation · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6S3C-2 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, GOL, KDK, MG Fragment AZ-019 binding at the p53pT387/14-3-3 sigma interface · p53pT387 (chains P) | unmapped |
| EV-PDB-6S40-2 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, CL, GOL, KTW, MG Fragment AZ-001 binding at the p53pT387/14-3-3 sigma interface and additional sites · p53pT387 (chains P) | unmapped |
| EV-PDB-6S9Q-2 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, L1T Fragment AZ-004 binding at a primary and secondary site in a p53pT387/14-3-3 complex · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6SHZ-1 RCSB PDB | xray | resolution: 1.24 Å | in vitro · -173.15 °C · ligands EDO, GOL, ZN p53 cancer mutant Y220C · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6SI0-1 RCSB PDB | xray | resolution: 1.53 Å | in vitro · -173.15 °C · ligands EDO, EPE, GOL, LEK, ZN p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9323 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6SI1-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · pH 7.2 · ligands EDO, EPE, GOL, ZN p53 cancer mutant Y220H · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6SI2-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands EDO, GOL, ZN p53 cancer mutant Y220S · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6SI3-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands EDO, GOL, LEB, ZN p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6SI4-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands GOL, LEK, ZN p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-6SIN-2 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · pH 7.5 · ligands K65 Fragment AZ-020 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6SIO-2 RCSB PDB | xray | resolution: 1.60418 Å | in vitro · -173.15 °C · ligands CL, LFQ, MG Fragment AZ-017 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6SIP-2 RCSB PDB | xray | resolution: 1.60045 Å | in vitro · -173.15 °C · ligands CL, LFB, MG Fragment AZ-011 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6SIQ-2 RCSB PDB | xray | resolution: 1.60121 Å | in vitro · -173.15 °C · ligands CL, LF5 Fragment AZ-012 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6SL6-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -173.15 °C · pH 7 · ligands GOL, ZN p53 charged core · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-6SLV-2 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7.5 · ligands CL, LJW, MG Fragment AZ-013 binding at the p53pT387/14-3-3 sigma interface · Cellular tumor antigen p53 (chains P) | unmapped |
| EV-PDB-6V4F-2 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 7 · ligands SO4 Crystal Structure Analysis of Zebra Fish MDMX · Stapled Peptide LSQETF(0EH)DLWKLE(MK8)EN(NH2) (chains B) | unmapped |
| EV-PDB-6V4H-2 RCSB PDB | xray | resolution: 1.53 Å | in vitro · -173.15 °C · pH 8 Crystal Structure Analysis of Zebra Fish MDMX · Stapled Peptide LSQETF(0EH)DLWKLL(MK8)EN(NH2) (chains B,D) | unmapped |
| EV-PDB-6VQO-5 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C · pH 8 T cell receptor-p53-HLA-A2 complex · peptide from p53 tumor suppressor (chains P,Q) | unmapped |
| EV-PDB-6VR1-3 RCSB PDB | xray | resolution: 2.37 Å | in vitro · -173.15 °C · pH 8 Complex of HLA-A2, a class I MHC, with a p53 peptide · Cellular tumor antigen p53 peptide (chains P,Q) | unmapped |
| EV-PDB-6VR5-3 RCSB PDB | xray | resolution: 2.38 Å | in vitro · -173.15 °C · pH 8 Complex of HLA-A2, a class I MHC, with a p53 peptide · Cellular tumor antigen p53 peptide (chains P,Q) | unmapped |
| EV-PDB-6VRM-5 RCSB PDB | xray | resolution: 2.61 Å | in vitro · -173.15 °C · pH 7 T cell receptor-p53-HLA-A2 complex · Cellular tumor antigen p53 peptide (chains P) | unmapped |
| EV-PDB-6VRN-5 RCSB PDB | xray | resolution: 2.46 Å | in vitro · -173.15 °C · pH 6.7 T cell receptor-p53-HLA-A2 complex · Cellular tumor antigen p53 peptide (chains P) | unmapped |
| EV-PDB-6W51-3 RCSB PDB | xray | resolution: 3.53 Å | in vitro · -173.15 °C · ligands PO4 Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H · Cellular tumor antigen p53 peptide (chains C,F,I,L) | unmapped |
| EV-PDB-6XRE-13 RCSB PDB | cryoem | resolution: 4.6 Å | in vitro · ligands MG, ZN Structure of the p53/RNA polymerase II assembly · Cellular tumor antigen p53 (chains M) | unmapped |
| EV-PDB-6ZNC-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · ligands QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7B46-1 RCSB PDB | xray | resolution: 2.02 Å | in vitro · -173.15 °C · ligands ACT, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (P1) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7B47-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.1 · ligands QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7B48-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 6.1 · ligands ACT, EDO, PEG, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7B49-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · pH 6.1 · ligands ACT, EDO, FMT, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-7B4A-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.1 · ligands FMT, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-7B4B-1 RCSB PDB | xray | resolution: 1.76 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, PEG, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7B4C-1 RCSB PDB | xray | resolution: 1.71 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, PEG, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (II) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7B4D-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 6.1 · ligands FMT, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7B4E-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 6.1 · ligands EDO, PG4, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7B4F-1 RCSB PDB | xray | resolution: 1.78 Å | in vitro · -173.15 °C · ligands FMT, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7B4G-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · -173.15 °C · ligands EDO, PEG, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7B4H-1 RCSB PDB | xray | resolution: 1.39 Å | in vitro · -173.15 °C · ligands ACT, EDO, FMT, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7B4N-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · ligands FMT, QN8, QNN, ZN Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7BWN-1 RCSB PDB | xray | resolution: 2.396 Å | in vitro · -173.15 °C · pH 5.5 Crystal Structure of a Designed Protein Heterocatenane · Chimera of Green fluorescent protein and p53dim (chains A,C,E,F,H,J,M,O) | unmapped |
| EV-PDB-7BWN-2 RCSB PDB | xray | resolution: 2.396 Å | in vitro · -173.15 °C · pH 5.5 Crystal Structure of a Designed Protein Heterocatenane · Cellular tumor antigen p53 (chains B,D,G,I,K,L,N,P) | unmapped |
| EV-PDB-7DHY-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · ligands ARS, GOL, SO4, ZN Arsenic-bound p53 DNA-binding domain mutant G245S · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7DHZ-1 RCSB PDB | xray | resolution: 1.74 Å | in vitro · -173.15 °C · pH 7 · ligands ARS, GOL, ZN Arsenic-bound p53 DNA-binding domain mutant R249S · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-7DVD-1 RCSB PDB | xray | resolution: 2.59 Å | in vitro · -173.15 °C · pH 7 · ligands ZN The crystal structure of p53 DNA binding domain and PUMA complex · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7EAX-1 RCSB PDB | xray | resolution: 2.55 Å | in vitro · -173.15 °C · pH 8.5 · ligands SB, ZN Crystal complex of p53-V272M and antimony ion · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-7EDS-1 RCSB PDB | xray | resolution: 1.77 Å | in vitro · -173.15 °C · ligands ARS, ZN Human p53 core domain with germline hot spot mutation M133T in complex with the natural PIG3 p53-response element and Arsenic · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7EEU-1 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -173.15 °C · ligands ARS, PEG, ZN Human p53 core domain with hot spot mutation R282W in complex with the natural CDKN1A(p21) p53-response element and Arsenic · Cellular tumor antigen p53 (chains A,B,C,D,E,F,G,H) | unmapped |
| EV-PDB-7EL4-1 RCSB PDB | xray | resolution: 2.11 Å | in vitro · -173.15 °C · pH 7.16 · ligands MG, O4B The crystal structure of p53p peptide fragment in complex with the N-terminal domain of MdmX · Cellular tumor antigen p53,Protein Mdm4 (chains A) | unmapped |
| EV-PDB-7NMI-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands CA, GOL Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7RM4-3 RCSB PDB | xray | resolution: 3.33 Å | in vitro · -173.15 °C · pH 8.5 Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2 · Cellular tumor antigen p53 peptide (chains C,H,M,R) | unmapped |
| EV-PDB-7V97-1 RCSB PDB | xray | resolution: 2.02 Å | in vitro · -173.15 °C · ligands ARS, ZN Arsenic-bound p53 DNA-binding domain mutant V272M · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-6T58-1 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -173.15 °C · ligands CA, GOL Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin A2 as a crystallization chaperone · Cellular tumor antigen p53,Protein S100-A4,Protein S100-A4,Annexin A2 (chains A,B) | unmapped |
| EV-PDB-7XZZ-7 RCSB PDB | cryoem | resolution: 4.07 Å | in vitro Cryo-EM structure of the nucleosome in complex with p53 · Cellular tumor antigen p53 (chains K,L,M,N) | unmapped |
| EV-PDB-7YGI-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands K, NA, PO4, ZN Crystal structure of p53 DBD domain in complex with azurin · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8A31-1 RCSB PDB | xray | resolution: 1.46 Å | in vitro · -173.15 °C · ligands GOL, KV0, ZN p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC694 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8A32-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · ligands EDO, GOL, KVA, ZN p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC769 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8A92-1 RCSB PDB | xray | resolution: 1.37 Å | in vitro · -173.15 °C · pH 7.15 · ligands EPE, LE9, PEG, ZN p53-Y220C Core Domain in Complex with a Bromo-trifluoro-pyrazole-amine · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8CG7-1 RCSB PDB | xray | resolution: 1.53 Å | in vitro · -173.15 °C · ligands A1IH3, EDO, ZN Structure of p53 cancer mutant Y220C with arylation at Cys182 and Cys277 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8DC4-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -193.15 °C · pH 7 · ligands R3R, ZN Crystal structure of p53 Y220C covalently bound to carbazole KG3 · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-8DC6-1 RCSB PDB | xray | resolution: 1.60001 Å | in vitro · -193.15 °C · pH 7 · ligands MG, R4F, SO4, ZN Crystal structure of p53 Y220C covalently bound to indole KG6 · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-8DC7-1 RCSB PDB | xray | resolution: 1.98701 Å | in vitro · -193.15 °C · pH 7 · ligands MG, R4R, SO4, ZN Crystal structure of p53 Y220C covalently bound to indole KG10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8DC8-1 RCSB PDB | xray | resolution: 1.7201 Å | in vitro · -193.15 °C · pH 7 · ligands MG, R50, SO4, ZN Crystal structure of p53 Y220C covalently bound to azaindole KG13 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8E7A-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · 17.85 °C · ligands ZN Crystal structure of the p53 (Y107H) core domain orthorhombic P form · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8E7B-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 17.85 °C · pH 6.5 · ligands ZN Crystal structure of the p53 (Y107H) core domain monoclinic P form · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8GCR-2 RCSB PDB | cryoem | resolution: 3.38 Å | in vitro · ligands ZN HPV16 E6-E6AP-p53 complex · Cellular tumor antigen p53 (chains B) | unmapped |
| EV-PDB-8HLL-1 RCSB PDB | xray | resolution: 2.62 Å | in vitro · -173.15 °C · pH 7.8 · ligands ZN Crystal structure of p53/BCL2 fusion complex (complex 1) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8HLM-1 RCSB PDB | xray | resolution: 2.522 Å | in vitro · -173.15 °C · pH 7.8 · ligands ZN Crystal structure of p53/BCL2 fusion complex (complex 2) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8J8N-2 RCSB PDB | cryoem | resolution: 9.02 Å | in vitro · ligands ZN Structure of p53 DNA-binding domain and ZNF568 KRAB domain complex · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-8OXM-1 RCSB PDB | cryoem | resolution: 3.3 Å | in vitro · ligands ANP, MG, ZN ATM(Q2971A) activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide · Cellular tumor antigen p53 (chains E,F) | unmapped |
| EV-PDB-8OXO-1 RCSB PDB | cryoem | resolution: 3 Å | in vitro · ligands ANP, MG, ZN ATM(Q2971A) dimeric C-terminal region activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide · Cellular tumor antigen p53 (chains E,F) | unmapped |
| EV-PDB-8QWK-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · ligands EDO, ZN Structure of p53 cancer mutant Y126C · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8QWL-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · ligands EDO, MLI, ZN Structure of p53 cancer mutant Y163C · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8QWM-1 RCSB PDB | xray | resolution: 1.54 Å | in vitro · -173.15 °C · ligands EDO, TLA, ZN Structure of p53 cancer mutant Y205C · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8QWN-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · ligands CL, EDO, MG, ZN Structure of p53 cancer mutant Y220C (hexagonal crystal form) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8QWO-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · ligands GOL, ZN Structure of p53 cancer mutant Y234C · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8QWP-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands EDO, TLA, ZN Structure of p53 cancer mutant Y236C · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8R1F-3 RCSB PDB | cryoem | resolution: 3.67 Å | in vitro · ligands ZN Monomeric E6AP-E6-p53 ternary complex · Cellular tumor antigen p53 (chains C) | unmapped |
| EV-PDB-8R1G-3 RCSB PDB | cryoem | resolution: 3.99 Å | in vitro · ligands ZN Dimeric ternary structure of E6AP-E6-p53 · Cellular tumor antigen p53 (chains C,F) | unmapped |
| EV-PDB-8RBA-1 RCSB PDB | xray | resolution: 1.57 Å | in vitro · -173.15 °C · pH 7.2 · ligands EDO, EPE, GOL, PEG, YLW, ZN p53-Y220C Core Domain Covalently Bound to 2,5,6-trifluoropyridine-3-carbonitrile Soaked at 5 mM · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8RBB-1 RCSB PDB | xray | resolution: 1.69 Å | in vitro · -173.15 °C · pH 7.2 · ligands EDO, EPE, GOL, YLW, ZN p53-Y220C Core Domain Covalently Bound to 2,5,6-trifluoropyridine-3-carbonitrile Soaked at 40 mM · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8RBC-1 RCSB PDB | xray | resolution: 2.06 Å | in vitro · -173.15 °C · pH 7.2 · ligands EPE, PEG, YM0, ZN p53-Y220C Core Domain Covalently Bound to 3-amino-5-chloropyrazine-2,6-dicarbonitrile Soaked at 5 mM · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8RCI-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · ligands EDO, ZN Human p53 DNA-binding domain bound to DARPin C10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-8WD2-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · ligands EDO, PO4, ZN The Crystal Structure of p53 from Biortus. · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8XCB-1 RCSB PDB | xray | resolution: 1.83 Å | in vitro · -173.15 °C · ligands A1LUZ, GOL, ZN Cocrystal structure of p53 in complex of B20 · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-8XCE-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8.5 · ligands A1LU0, ZN cocrystal structure of p53 in complex of B23 · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-8XP5-1 RCSB PDB | xray | resolution: 2.55 Å | in vitro · -173.15 °C · ligands ZN The Crystal Structure of p53/BCL-xL fusion complex from Biortus. · Bcl-2-like protein 1,Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-8ZZN-3 RCSB PDB | integrative | structure | in vitro Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex · p53 (chains C) | unmapped |
| EV-PDB-9A9W-7 RCSB PDB | integrative | structure | in vitro · ligands ZN USP7 bound to a nucleosome/p53 complex · Cellular tumor antigen p53 (chains K,L,M,N) | unmapped |
| EV-PDB-9BR3-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands A1ARO, ZN Crystal structure of p53 Y220C mutant in complex with PC-10709 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9BR4-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands A1ARZ, CL, ZN Crystal structure of p53 Y220C mutant in complex with PC-9859 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9CHT-2 RCSB PDB | cryoem | resolution: 3.54 Å | in vitro Human E3 ligase E6AP in complex with HPV16-E6 and p53 · Immunoglobulin G-binding protein G/Cellular tumor antigen p53 fusion protein (chains B) | unmapped |
| EV-PDB-9EIQ-3 RCSB PDB | xray | resolution: 2.21 Å | in vitro · -173.15 °C · pH 8.5 · ligands CL, EDO, NI, SO4 Crystal structure of HLA-B*07:02 with the 9-mer TP53 peptide RPILTIITL · Peptide from Cellular tumor antigen p53 (chains C,F) | unmapped |
| EV-PDB-9EJD-3 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · pH 8.5 · ligands CL, EDO, NI, SO4 Crystal structure of HLA-B*07:02 with the 9-mer TP53 mutant peptide SPILTIITL · Peptide from Cellular tumor antigen p53 (chains C,F) | unmapped |
| EV-PDB-9EK4-3 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · pH 8.5 · ligands ACY, CL, EDO, NI, SO4, ZN Crystal structure of HLA-B*07:02 with the 9-mer TP53 mutant peptide MPILTIITL · Mutant peptide from Cellular tumor antigen p53 (chains C,F) | unmapped |
| EV-PDB-9FZB-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · ligands EDO, ZN Human p53 DNA-binding domain bound to DARPin C10-H82R · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9G5H-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 7.2 · ligands A1IIO, EDO, EPE, GOL, PEG, ZN p53-Y220C Core Domain Covalently Bound to 2-chloro-5-cyanopyrazine Soaked at 5 mM · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9G6T-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · -173.15 °C · pH 7.2 · ligands A1II4, EDO, EPE, GOL, PEG, ZN p53-Y220C Core Domain Covalently Bound to 5-Chloro-6-methylpyrazine-2-carbonitrile Soaked at 5 mM · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9G6U-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · pH 7.2 · ligands A1II1, EDO, EPE, GOL, PEG, PGE, ZN p53-Y220C Core Domain Covalently Bound to 3,5-Dichloro-6-Ethylpyrazine-2-carbonitirle Soaked at 5 mM · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9C5S-1 RCSB PDB | xray | resolution: 1.01 Å | in vitro · -173.15 °C · pH 6.5 · ligands SO4 Disulfide-linked, antiparallel p53-derived peptide dimer (CV1) · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-8UQR-1 RCSB PDB | xray | resolution: 1.22 Å | in vitro · -173.15 °C Crystal structure of the human p53 tetramerization domain · Cellular tumor antigen p53 (chains A,B,C,D) | unmapped |
| EV-PDB-8HLN-1 RCSB PDB | xray | resolution: 2.354 Å | in vitro · -173.15 °C · pH 7.8 · ligands ZN Crystal structure of p53/BCL2 fusion complex(complex3) · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-7XZX-7 RCSB PDB | cryoem | resolution: 4.53 Å | in vitro Cryo-EM structure of the nucleosome in complex with p53 DNA-binding domain · Cellular tumor antigen p53 (chains K,L,M,N) | unmapped |
| EV-PDB-9R2Q-7 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro p53 bound to nucleosome at position SHL-5.7 (non-crosslinked sample) · Cellular tumor antigen p53 (chains K,L,M,N) | unmapped |
| EV-PDB-9S9P-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands A1JMR, EDO, NO3, ZN Crystal structure of p53 cancer mutant Y220S in complex with rezatapopt · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9S9Q-1 RCSB PDB | xray | resolution: 1.87 Å | in vitro · -173.15 °C · ligands A1JMR, EDO, PEG, ZN Crystal structure of p53 cancer mutant Y220N in complex with rezatapopt · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9S9R-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands EDO, ZN Crystal structure of p53 cancer mutant Y220N · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9SPM-1 RCSB PDB | xray | resolution: 1.71 Å | in vitro · -173.15 °C · ligands EDO, ZN p53 cancer mutant V143A in complex with DARPin C10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9SPN-1 RCSB PDB | xray | resolution: 1.93 Å | in vitro · -173.15 °C · ligands EDO, ZN p53 cancer mutant V157F in complex with DARPin C10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9SPO-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · ligands EDO, ZN p53 cancer mutant Y220C in complex with DARPin C10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9SPP-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · ligands EDO, ZN p53 cancer mutant Y234C in complex with DARPin C10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9SPQ-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands EDO, ZN p53 cancer mutant V272M in complex with DARPin C10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9SPR-1 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · ligands EDO, ZN p53 cancer mutant R282W in complex with DARPin C10 · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9SPS-1 RCSB PDB | xray | resolution: 1.42 Å | in vitro · -173.15 °C · ligands EDO, SO4, ZN p53 cancer mutant E285K in complex with DARPin C10-H82R · Cellular tumor antigen p53 (chains A) | unmapped |
| EV-PDB-9SUK-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · -173.15 °C · pH 7.2 · ligands A1JQW, EDO, EPE, GOL, PEG, ZN p53-R282W Core Domain Covalently Bound to a Vinyl-Sulfone Fragment · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9SZZ-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands A1JQW, EDO, EPE, PEG, PGE, ZN p53-Y220C Core Domain Covalently Bound to a Vinyl-Sulfone Fragment · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9U4D-2 RCSB PDB | cryoem | resolution: 3.39 Å | in vitro · ligands ZN Structure of UBE3A-E6-p53 complex · Cellular tumor antigen p53 (chains C) | unmapped |
| EV-PDB-9YZH-3 RCSB PDB | xray | resolution: 3.25 Å | in vitro · -173.15 °C · ligands CL, EDO Crystal structure of HLA*02:01 with the 11-mer TP53 mutant peptide GLAPPQHLFRV · Peptide from Cellular tumor antigen p53 (chains C,F) | unmapped |
| EV-PDB-9S9O-1 RCSB PDB | xray | resolution: 1.49 Å | in vitro · -173.15 °C · ligands A1JMR, EDO, ZN Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9S9N-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · ligands A1JMP, EDO, ZN Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt analog 8 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9S9M-1 RCSB PDB | xray | resolution: 1.83 Å | in vitro · -173.15 °C · ligands A1JMO, EDO, ZN Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt analog 7 · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9S9L-1 RCSB PDB | xray | resolution: 1.38 Å | in vitro · -173.15 °C · ligands A1JMS, EDO, GOL, ZN Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt precursor · Cellular tumor antigen p53 (chains A,B) | unmapped |
| EV-PDB-9R2P-7 RCSB PDB | cryoem | resolution: 4.18 Å | in vitro p53 bound to nucleosome at position SHL+5.9 (crosslinked sample) · Cellular tumor antigen p53 (chains K,L,M,N) | unmapped |
| EV-PDB-9R2M-7 RCSB PDB | cryoem | resolution: 3.5 Å | in vitro p53 bound to nucleosome at position SHL+5.9 (non-crosslinked sample, composite map) · Cellular tumor antigen p53 (chains K,L,M,N) | unmapped |
| EV-PDB-9R04-7 RCSB PDB | cryoem | resolution: 4.2 Å | in vitro p53 bound to the nucleosome at position SHL-5.7 (crosslinked sample) · Cellular tumor antigen p53 (chains K,L,M,N) | unmapped |
| EV-PDB-9OBF-3 RCSB PDB | xray | resolution: 3.25 Å | in vitro · -173.15 °C · pH 7 · ligands EDO Crystal structure of HLA*02:01 with the 11-mer TP53 peptide GLAPPQHLIRV · Peptide from Cellular tumor antigen p53 (chains C,F) | unmapped |
| EV-BMRB-11578 BMRB | nmr_shifts | chemical_shift | in vitro · 31.85 °C · pH 6.8 Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-15944 BMRB | nmr_shifts | chemical_shift | in vitro · 34.85 °C · pH 6.3 Structural Basis for the Regulation of p53 Function by p300 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17073 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Structure of CBP nuclear coactivator binding domain in complex with p53 TAD · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17760 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 7.4 backbone resonance assignments of p53 N-terminal transactivation domain (1-93) · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18709 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25347 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.5 Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25348 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.5 Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-25377 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 MDMX-P53 · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-25484 BMRB | nmr_shifts | chemical_shift | in vitro · -0.15 °C · pH 6.3 Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30002 BMRB | nmr_shifts | chemical_shift | in vitro · 34.85 °C · pH 6.8 Solution Structure of p53TAD-TAZ1 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-4048 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 7 Solution Structure of the tetrameric minimum transforming domain of p53 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-51613 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 p53 C-terminal · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-6521 BMRB | nmr_shifts | chemical_shift | in vitro · 19.85 °C · pH 6 Characterization of an amyloid fibril intermediate · BMRB data: 1H chemical shifts, 15N chemical shifts, 13C chemical shifts | unmapped |
| EV-BMRB-7251 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 7.2 1H chemical shift assignments for wild type p53 tetramerization domain · BMRB data: 1H chemical shifts | unmapped |
| EV-SASBDB-SASDY42 SASBDB | saxs_sans | radius_of_gyration: 2.25 nm ± 0.012 | in vitro · 20 °C · pH 7 Conformational Flexibility and Transient Structure of the Proline-Rich Domain in p53. · Cellular tumor antigen p53 | unmapped |
| EV-SASBDB-SASDY52 SASBDB | saxs_sans | radius_of_gyration: 2.19 nm ± 0.012 | in vitro · 20 °C · pH 7 Conformational Flexibility and Transient Structure of the Proline-Rich Domain in p53. · Cellular tumor antigen p53 | unmapped |
| EV-SASBDB-SASDY62 SASBDB | saxs_sans | radius_of_gyration: 2.15 nm ± 0.026 | in vitro · 20 °C · pH 7 Conformational Flexibility and Transient Structure of the Proline-Rich Domain in p53. · Cellular tumor antigen p53 P72R | unmapped |
| EV-SASBDB-SASDY72 SASBDB | saxs_sans | radius_of_gyration: 2.32 nm ± 0.013 | in vitro · 20 °C · pH 7 Conformational Flexibility and Transient Structure of the Proline-Rich Domain in p53. · Cellular tumor antigen p53 P72R | unmapped |
| EV-SASBDB-SASDY82 SASBDB | saxs_sans | radius_of_gyration: 2.22 nm ± 0.027 | in vitro · 20 °C · pH 7 Conformational Flexibility and Transient Structure of the Proline-Rich Domain in p53. · Cellular tumor antigen p53 P82L | unmapped |
| EV-SASBDB-SASDY92 SASBDB | saxs_sans | radius_of_gyration: 2.26 nm ± 0.011 | in vitro · 20 °C · pH 7 Conformational Flexibility and Transient Structure of the Proline-Rich Domain in p53. · Cellular tumor antigen p53 P82L | unmapped |
| EV-DISPROT-DP00086r008 DisProt | nmr_shifts | disorder_region: 12 residues | in vitro DisProt DP00086: disorder, residues 1-12 · residues 1-12; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r013 DisProt | nmr_shifts | disorder_region: 93 residues | in vitro DisProt DP00086: disorder, residues 1-93 · residues 1-93; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r018 DisProt | xray | disorder_region: 22 residues | in vitro DisProt DP00086: disorder, residues 291-312 · residues 291-312; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-DISPROT-DP00086r024 DisProt | saxs_sans | disorder_region: 93 residues | in vitro DisProt DP00086: disorder, residues 1-93 · residues 1-93; evidence: small-angle X-ray scattering evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r030 DisProt | xray | disorder_region: 21 residues | in vitro DisProt DP00086: disorder to order, residues 37-57 · residues 37-57; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r032 DisProt | xray | disorder_region: 13 residues | in vitro DisProt DP00086: disorder to order, residues 17-29 · residues 17-29; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r038 DisProt | xray | disorder_region: 20 residues | in vitro DisProt DP00086: disorder to order, residues 367-386 · residues 367-386; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r040 DisProt | xray | disorder_region: 22 residues | in vitro DisProt DP00086: disorder to order, residues 41-62 · residues 41-62; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r043 DisProt | xray | disorder_region: 11 residues | in vitro DisProt DP00086: disorder to order, residues 17-27 · residues 17-27; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r047 DisProt | nmr_shifts | disorder_region: 47 residues | in vitro DisProt DP00086: disorder to order, residues 14-60 · residues 14-60; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r051 DisProt | nmr_shifts | disorder_region: 21 residues | in vitro DisProt DP00086: disorder to order, residues 366-386 · residues 366-386; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r055 DisProt | xray | disorder_region: 11 residues | in vitro DisProt DP00086: disorder to order, residues 375-385 · residues 375-385; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r057 DisProt | xray | disorder_region: 22 residues | in vitro DisProt DP00086: disorder to order, residues 367-388 · residues 367-388; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r064 DisProt | nmr_shifts | disorder_region: 39 residues | in vitro DisProt DP00086: disorder to order, residues 1-39 · residues 1-39; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r066 DisProt | nmr_shifts | disorder_region: 15 residues | in vitro DisProt DP00086: disorder to order, residues 42-56 · residues 42-56; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r071 DisProt | nmr_shifts | disorder_region: 73 residues | in vitro DisProt DP00086: disorder, residues 1-73 · residues 1-73; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r072 DisProt | cd | disorder_region: 73 residues | in vitro DisProt DP00086: disorder, residues 1-73 · residues 1-73; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r075 DisProt | nmr_shifts | disorder_region: 27 residues | in vitro DisProt DP00086: disorder, residues 20-46 · residues 20-46; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r076 DisProt | nmr_shifts | disorder_region: 15 residues | in vitro DisProt DP00086: disorder, residues 56-70 · residues 56-70; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r077 DisProt | nmr_shifts | disorder_region: 61 residues | in vitro DisProt DP00086: disorder, residues 1-61 · residues 1-61; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r085 DisProt | nmr_shifts | disorder_region: 33 residues | in vitro DisProt DP00086: disorder, residues 361-393 · residues 361-393; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r086 DisProt | nmr_shifts | disorder_region: 33 residues | in vitro DisProt DP00086: disorder, residues 361-393 · residues 361-393; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r088 DisProt | cd | disorder_region: 22 residues | in vitro DisProt DP00086: disorder, residues 367-388 · residues 367-388; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r089 DisProt | cd | disorder_region: 93 residues | in vitro DisProt DP00086: disorder, residues 1-93 · residues 1-93; evidence: near-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r090 DisProt | cd | disorder_region: 93 residues | in vitro DisProt DP00086: disorder, residues 1-93 · residues 1-93; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r091 DisProt | fluorescence | disorder_region: 93 residues | in vitro DisProt DP00086: disorder, residues 1-93 · residues 1-93; evidence: fluorescence evidence used in manual assertion | unmapped |
| EV-DISPROT-DP00086r092 DisProt | nmr_shifts | disorder_region: 93 residues | in vitro DisProt DP00086: disorder, residues 1-93 · residues 1-93; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-AFDB-AF-P04637-F1 AlphaFold DB | af_prediction | plddt: 75.06 pLDDT | in silico AlphaFold DB prediction AF-P04637-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-393 | unmapped |
| EV-MDDB-A0024 MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1AIE · start 1AIE; Amber Parm99 | unmapped |
| EV-SMASH-SMFS-000065 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Counteraction of HMGB1 at ss-dsDNA junctions maintains liquidity of protamine-DNA co-condensates. · p53; optical tweezers; experiment class: chromatin_mechanics, nucleic_acid_mechanics, nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-002848 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing direct interaction of oncomiR-21-3p with the tumor suppressor p53 by fluorescence, FRET and atomic force spectroscopy. · p53; force spectroscopy unspecified; experiment class: nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-003131 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Imaging and kinetics of the bimolecular complex formed by the tumor suppressor p53 with ubiquitin ligase COP1 as studied by atomic force microscopy and surface plasmon resonance. · p53; afm smfs; experiment class: nucleic_acid_protein_interaction, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003746 SMASH-BIO | force_spectroscopy | study_record | in vitro Surface Plasmon Resonance Sensing of Biorecognition Interactions within the Tumor Suppressor p53 Network. · p53; force spectroscopy unspecified; experiment class: nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-004266 SMASH-BIO | force_spectroscopy | study_record | in vitro Label-free free-solution nanoaperture optical tweezers for single molecule protein studies. · p53; optical tweezers; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004448 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins. · p53; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-004530 SMASH-BIO | force_spectroscopy | study_record | in vitro Double nanohole optical tweezers visualize protein p53 suppressing unzipping of single DNA-hairpins. · p53; optical tweezers; experiment class: nucleic_acid_protein_interaction, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004578 SMASH-BIO | force_spectroscopy | study_record | in vitro Interaction of mutant p53 with p73: a Surface Plasmon Resonance and Atomic Force Spectroscopy study. · p53; afm smfs; experiment class: translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-005397 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Variation in the mechanical unfolding pathway of p53DBD induced by interaction with p53 N-terminal region or DNA. · p53; afm smfs; experiment class: nucleic_acid_protein_interaction, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005513 SMASH-BIO | force_spectroscopy | study_record | in vitro Free energy evaluation of the p53-Mdm2 complex from unbinding work measured by dynamic force spectroscopy. · p53; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005536 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Interaction of an anticancer peptide fragment of azurin with p53 and its isolated domains studied by atomic force spectroscopy. · p53; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-005820 SMASH-BIO | force_spectroscopy | study_record | in vitro Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy. · p53; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006423-r0 SMASH-BIO | force_spectroscopy | unbinding_force: 70 pN | in vitro Probing the interaction between p53 and the bacterial protein azurin by single molecule force spectroscopy. · p53; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007046 SMASH-BIO | force_spectroscopy | study_record | in vitro Progressing single biomolecule force spectroscopy measurements for the screening of DNA binding agents. · p53; force spectroscopy unspecified; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
Conflicts
No conflicts found among comparable evidence.
382 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.