von Willebrand factor
UniProt P04275 · gene VWF · Homo sapiens · 2813 residues
127evidence items
0mapped to a state
0states
6techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | saxs_sans | force_spectroscopy | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 127 of 127 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| BMRB | 2 | 0 |
| DisProt | 1 | 0 |
| RCSB PDB | 57 | 0 |
| SASBDB | 11 | 0 |
| SMASH-BIO | 56 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-3PPX-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 5.2 · ligands NA Crystal structure of the N1602A mutant of an engineered VWF A2 domain (N1493C and C1670S) · von Willebrand factor (chains A) | unmapped |
| EV-PDB-7PMV-1 RCSB PDB | cryoem | resolution: 3.7 Å | in vitro · ligands CA, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose VWF Tubules of D1D2D'D3 domains · von Willebrand factor (chains A,B,D,E) | unmapped |
| EV-PDB-8D3D-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands CA, NAG VWF tubule derived from dimeric D1-A1 · von Willebrand factor (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P) | unmapped |
| EV-PDB-8D3C-1 RCSB PDB | cryoem | resolution: 3.1 Å | in vitro · ligands CA, NAG VWF tubule derived from monomeric D1-A1 · von Willebrand factor (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P) | unmapped |
| EV-PDB-7ZWH-2 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands CA, NAG, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose VWF Tubules of D1D2 and D'D3A1 domains · von Willebrand factor (chains G,H) | unmapped |
| EV-PDB-7ZWH-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands CA, NAG, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose VWF Tubules of D1D2 and D'D3A1 domains · von Willebrand factor (chains D,E) | unmapped |
| EV-PDB-7WQT-2 RCSB PDB | cryoem | resolution: 4.3 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (VWF tube) · von Willebrand factor (chains C,D,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f) | unmapped |
| EV-PDB-7WQT-1 RCSB PDB | cryoem | resolution: 4.3 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (VWF tube) · von Willebrand antigen 2 (chains A,B,E,F,G,H,I,J,K,L,M,N,O,P,Q,R) | unmapped |
| EV-PDB-7WPS-2 RCSB PDB | cryoem | resolution: 4.32 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (7 units) · von Willebrand factor (chains C,D,F,H,J,L,N,P,R,T,V,X,Z,b) | unmapped |
| EV-PDB-7WPS-1 RCSB PDB | cryoem | resolution: 4.32 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (7 units) · von Willebrand antigen 2 (chains A,B,E,G,I,K,M,O,Q,S,U,W,Y,a) | unmapped |
| EV-PDB-7WPR-2 RCSB PDB | cryoem | resolution: 4.39 Å | in vitro · ligands CA, NAG VWF D'D3 dimer complexed with D1D2 at 4.39 angstron resolution(VWF tube) · von Willebrand factor (chains C,D,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f) | unmapped |
| EV-PDB-7WPR-1 RCSB PDB | cryoem | resolution: 4.39 Å | in vitro · ligands CA, NAG VWF D'D3 dimer complexed with D1D2 at 4.39 angstron resolution(VWF tube) · von Willebrand antigen 2 (chains A,B,E,F,G,H,I,J,K,L,M,N,O,P,Q,R) | unmapped |
| EV-PDB-7WPQ-2 RCSB PDB | cryoem | resolution: 3.267 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 3.27 angstron resolution (2 units) · von Willebrand factor (chains C,D,F,H) | unmapped |
| EV-PDB-7WPQ-1 RCSB PDB | cryoem | resolution: 3.267 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 3.27 angstron resolution (2 units) · von Willebrand antigen 2 (chains A,B,E,G) | unmapped |
| EV-PDB-7WPP-2 RCSB PDB | cryoem | resolution: 2.85 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 2.85 angstron resolution (1 unit) · von Willebrand factor (chains F,H) | unmapped |
| EV-PDB-7WPP-1 RCSB PDB | cryoem | resolution: 2.85 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 2.85 angstron resolution (1 unit) · von Willebrand antigen 2 (chains E,G) | unmapped |
| EV-PDB-7WN6-2 RCSB PDB | cryoem | resolution: 3.29 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer (R1136M/E1143M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units) · von Willebrand factor (chains C,D,F,H) | unmapped |
| EV-PDB-7WN6-1 RCSB PDB | cryoem | resolution: 3.29 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer (R1136M/E1143M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units) · von Willebrand antigen 2 (chains A,B,E,G) | unmapped |
| EV-PDB-7WN4-2 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer (wild type) complexed with D1D2 at 3.4 angstron resolution (1 unit) · von Willebrand factor (chains F,H) | unmapped |
| EV-PDB-7WN4-1 RCSB PDB | cryoem | resolution: 3.4 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer (wild type) complexed with D1D2 at 3.4 angstron resolution (1 unit) · von Willebrand antigen 2 (chains E,G) | unmapped |
| EV-PDB-7WN3-2 RCSB PDB | cryoem | resolution: 3.29 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units) · von Willebrand factor (chains C,D,F,H) | unmapped |
| EV-PDB-7WN3-1 RCSB PDB | cryoem | resolution: 3.29 Å | in vitro · ligands CA, NAG Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units) · von Willebrand antigen 2 (chains A,B,E,G) | unmapped |
| EV-PDB-7PNF-1 RCSB PDB | cryoem | resolution: 4.35 Å | in vitro · ligands CA, NAG, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose VWF Tubules of D1D2D'D3 domains · von Willebrand factor (chains B,D) | unmapped |
| EV-PDB-7P4N-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 NMR solution structure of the C6 domain of von Willebrand Factor · von Willebrand factor (chains A) | unmapped |
| EV-PDB-7KWO-2 RCSB PDB | cryoem | resolution: 2.9 Å | in vitro · ligands CA, CU, NAG, ZN, branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose rFVIIIFc-VWF-XTEN (BIVV001) · von Willebrand factor-XTEN-Fc (chains V) | unmapped |
| EV-PDB-7F49-1 RCSB PDB | xray | resolution: 2.09 Å | in vitro · -173.15 °C · ligands GOL von Willebrand factor (VWF) A1 domain with BT-100 aptamer RNA · von Willebrand factor (chains A) | unmapped |
| EV-PDB-7EOW-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8 High-resolution structure of vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine · von Willebrand factor (chains A) | unmapped |
| EV-PDB-6N29-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · ligands CA, NAG, PEG Crystal structure of monomeric von Willebrand Factor D`D3 assembly · von Willebrand factor (chains A,B) | unmapped |
| EV-PDB-6FWN-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.5 Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor · von Willebrand factor (chains A) | unmapped |
| EV-PDB-5BV8-1 RCSB PDB | xray | resolution: 1.59 Å | in vitro · -173.15 °C · pH 10.5 · ligands CL, EDO G1324S mutation in von Willebrand Factor A1 domain · von Willebrand factor (chains A) | unmapped |
| EV-PDB-4NT5-1 RCSB PDB | xray | resolution: 3.281 Å | in vitro · -173.15 °C · pH 8.3 · ligands NAG, SO4, ZN Crystal structure of human von Willebrand factor CTCK domain · von Willebrand factor (chains A) | unmapped |
| EV-PDB-4DMU-2 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 6.5 · ligands SO4 Crystal structure of the von Willebrand factor A3 domain in complex with a collagen III derived triple-helical peptide · von Willebrand factor (chains B,D,F,H,J,L) | unmapped |
| EV-PDB-4C2B-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -180.15 °C · pH 4.6 · ligands MES, PEG, SO4 Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha · VON WILLEBRAND FACTOR (chains A,C,E,G) | unmapped |
| EV-PDB-4C2A-1 RCSB PDB | xray | resolution: 2.081 Å | in vitro · -180.15 °C · pH 6.5 · ligands ACT, CA, CAC, PEG Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha · VON WILLEBRAND FACTOR (chains A) | unmapped |
| EV-PDB-4C29-1 RCSB PDB | xray | resolution: 2.202 Å | in vitro · -180.15 °C · pH 4.6 · ligands ACT, CA, PEG Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation · VON WILLEBRAND FACTOR (chains A,B) | unmapped |
| EV-PDB-3ZQK-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands CA, GOL, NAG Von Willebrand Factor A2 domain with calcium · VON WILLEBRAND FACTOR (chains A,B,C) | unmapped |
| EV-PDB-3PPY-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 5.2 · ligands NA Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S) · von Willebrand factor (chains A) | unmapped |
| EV-PDB-3PPW-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 5.2 · ligands NA Crystal structure of the D1596A mutant of an engineered VWF A2 domain (N1493C and C1670S) · von Willebrand factor (chains A) | unmapped |
| EV-PDB-3PPV-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 5.2 · ligands CA, SO4 Crystal structure of an engineered VWF A2 domain (N1493C and C1670S) · von Willebrand factor (chains A) | unmapped |
| EV-PDB-3HXQ-1 RCSB PDB | xray | resolution: 2.694 Å | in vitro · -173.15 °C · pH 4.6 Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding · von Willebrand Factor (chains A) | unmapped |
| EV-PDB-3HXO-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 7.1 Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding · von Willebrand factor (chains A) | unmapped |
| EV-PDB-3GXB-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7.2 · ligands NAG, SO4, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Crystal structure of VWF A2 domain · von Willebrand factor (chains A,B) | unmapped |
| EV-PDB-2MHQ-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.4 Solution structure of the major factor VIII binding region on von Willebrand factor · von Willebrand factor (chains A) | unmapped |
| EV-PDB-2MHP-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.4 Solution structure of the major factor VIII binding region on von Willebrand factor · von Willebrand factor (chains A) | unmapped |
| EV-PDB-2ADF-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 4.6 · ligands ACY, GOL, SO4 Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain · Von Willebrand factor (chains A) | unmapped |
| EV-PDB-1UEX-3 RCSB PDB | xray | resolution: 2.85 Å | in vitro · -173.15 °C · pH 7.8 Crystal structure of von Willebrand Factor A1 domain complexed with snake venom bitiscetin · von Willebrand Factor (chains C) | unmapped |
| EV-PDB-1U0N-1 RCSB PDB | xray | resolution: 2.95 Å | in vitro · -173.15 °C · pH 7.5 The ternary von Willebrand Factor A1-glycoprotein Ibalpha-botrocetin complex · Von Willebrand factor (chains A) | unmapped |
| EV-PDB-1SQ0-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 8 Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution · Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II] (chains A) | unmapped |
| EV-PDB-1OAK-3 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -183.15 °C · pH 8 CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH THE FUNCTION BLOCKING NMC-4 FAB · VON WILLEBRAND FACTOR (chains A) | unmapped |
| EV-PDB-1M10-1 RCSB PDB | xray | resolution: 3.1 Å | in vitro · -173.15 °C · pH 5.5 Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain · von Willebrand Factor (chains A) | unmapped |
| EV-PDB-1IJK-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -162.15 °C · pH 5.6 The von Willebrand Factor mutant (I546V) A1 domain-botrocetin Complex · von Willebrand factor (chains A) | unmapped |
| EV-PDB-1IJB-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -177.15 °C · pH 5.6 The von Willebrand Factor mutant (I546V) A1 domain · von Willebrand factor (chains A) | unmapped |
| EV-PDB-1FNS-3 RCSB PDB | xray | resolution: 2 Å | in vitro · -183.15 °C CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4 · VON WILLEBRAND FACTOR (chains A) | unmapped |
| EV-PDB-1FE8-1 RCSB PDB | xray | resolution: 2.03 Å | in vitro · -173.15 °C · pH 5.5 · ligands CAC, NAG, branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING · VON WILLEBRAND FACTOR (chains A,B,C) | unmapped |
| EV-PDB-1AUQ-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 8.5 · ligands CD A1 DOMAIN OF VON WILLEBRAND FACTOR · A1 DOMAIN OF VON WILLEBRAND FACTOR (chains A) | unmapped |
| EV-PDB-1ATZ-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8.5 HUMAN VON WILLEBRAND FACTOR A3 DOMAIN · VON WILLEBRAND FACTOR (chains A,B) | unmapped |
| EV-PDB-1AO3-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · 13.85 °C · pH 8.5 A3 DOMAIN OF VON WILLEBRAND FACTOR · VON WILLEBRAND FACTOR (chains A,B) | unmapped |
| EV-BMRB-34243 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-34648 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 NMR solution structure of the C6 domain of von Willebrand Factor · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-SASBDB-SASDKT8 SASBDB | saxs_sans | radius_of_gyration: 3.08 nm ± 0.03 | in vitro · 20 °C · pH 7.4 An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution. · von Willebrand factor | unmapped |
| EV-SASBDB-SASDKU8 SASBDB | saxs_sans | radius_of_gyration: 3.04 nm ± 0.024 | in vitro · 20 °C · pH 7.4 An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution. · von Willebrand factor | unmapped |
| EV-SASBDB-SASDKV8 SASBDB | saxs_sans | radius_of_gyration: 4.38 nm ± 0.014 | in vitro · 20 °C · pH 7.4 · ligands partner: A disintegrin and metalloproteinase with thrombospondin motifs 13 An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution. · von Willebrand factor with A disintegrin and metalloproteinase with thrombospondin motifs 13 | unmapped |
| EV-SASBDB-SASDLQ9 SASBDB | saxs_sans | radius_of_gyration: 1.749 nm ± 0.006 | in vitro · 20 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor C6 domain wild type | unmapped |
| EV-SASBDB-SASDLR9 SASBDB | saxs_sans | radius_of_gyration: 1.8 nm ± 0.01 | in vitro · 20 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor C6 domain G2705K mutant | unmapped |
| EV-SASBDB-SASDLS9 SASBDB | saxs_sans | radius_of_gyration: 3.27 nm ± 0.023 | in vitro · 25 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor C6-CK wildtype | unmapped |
| EV-SASBDB-SASDLT9 SASBDB | saxs_sans | radius_of_gyration: 3.453 nm ± 0.012 | in vitro · 25 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor C6-CK G2705R | unmapped |
| EV-SASBDB-SASDLU9 SASBDB | saxs_sans | radius_of_gyration: 3.515 nm ± 0.012 | in vitro · 25 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor C6-CK G2705K | unmapped |
| EV-SASBDB-SASDLV9 SASBDB | saxs_sans | radius_of_gyration: 7.808 nm ± 0.019 | in vitro · 20 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor D4N-CK wildtype | unmapped |
| EV-SASBDB-SASDLW9 SASBDB | saxs_sans | radius_of_gyration: 11.356 nm ± 0.076 | in vitro · 20 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor D4N-CK G2705R | unmapped |
| EV-SASBDB-SASDLX9 SASBDB | saxs_sans | radius_of_gyration: 9.812 nm ± 0.053 | in vitro · 20 °C · pH 7.5 Structure and dynamics of the von Willebrand Factor C6 domain · von Willebrand factor D4N-CK G2705K | unmapped |
| EV-DISPROT-DP02981r001 DisProt | xray | disorder_region: 16 residues | in vitro DisProt DP02981: disorder, residues 1478-1493 · residues 1478-1493; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-SMASH-SMFS-000136 SMASH-BIO | force_spectroscopy | study_record | in vitro Identification of missense variants in the C-domains of von Willebrand factor that cause gain-of-function-like activity. · von Willebrand factor; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000170 SMASH-BIO | force_spectroscopy | study_record | in vitro Magnetic Tweezers Experiments Reveal Increased Mechanical Sensitivity of the F2561Y Mutant in Von Willebrand Factor · von Willebrand factor; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000171 SMASH-BIO | force_spectroscopy | study_record | in vitro Magnetic Tweezers Experiments Reveal Increased Mechanical Sensitivity of the F2561Y Mutant in von Willebrand Factor. · von Willebrand factor; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000225 SMASH-BIO | force_spectroscopy | study_record | in vitro Optical-Tweezer Single-Molecule Assay for ADAMTS13-Mediated Proteolysis of the von Willebrand Factor A2 Domain. · von Willebrand factor; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000386 SMASH-BIO | force_spectroscopy | study_record | in vitro Aptamer-based biotherapeutic conjugate for shear responsive release of Von Willebrand factor A1 domain. · von Willebrand factor; optical tweezers; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000652 SMASH-BIO | force_spectroscopy | study_record | in vitro Unfolding of von Willebrand Factor Type D Like Domains Promotes Mucin Adhesion. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-000656 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Vicinal disulfide bond modulates A1-GPIbα interaction by altering the force-induced conformational changes of A2 domain. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001231 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Mechano-covalent protection of coagulation factor VIII by von Willebrand factor. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001387 SMASH-BIO | force_spectroscopy | study_record | in vitro A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization. · von Willebrand factor; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001420 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Autoinhibitory module underlies species difference in shear activation of von Willebrand factor. · von Willebrand factor; afm smfs; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001536 SMASH-BIO | force_spectroscopy | study_record | in vitro Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001754 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8.5 The N-terminal autoinhibitory module of the A1 domain in von Willebrand factor stabilizes the mechanosensor catch bond. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001766 SMASH-BIO | force_spectroscopy | study_record | in vitro The soluble N-terminal autoinhibitory module of the A1 domain in von Willebrand factor partially suppresses its catch bond with glycoprotein Ibα in a sandwich complex. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001807 SMASH-BIO | force_spectroscopy | study_record | in vitro AFM Identifies a Protein Complex Involved in Pathogen Adhesion Which Ruptures at Three Nanonewtons. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001814 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-001874 SMASH-BIO | force_spectroscopy | study_record | in vitro Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002158 SMASH-BIO | force_spectroscopy | study_record | in vitro Staphylococcus aureus vWF-binding protein triggers a strong interaction between clumping factor A and host vWF. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002348 SMASH-BIO | force_spectroscopy | study_record | in vitro Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor. · von Willebrand factor; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002612 SMASH-BIO | force_spectroscopy | study_record | in vitro A mechano-reactive coarse-grained model of the blood-clotting agent von Willebrand factor. · von Willebrand factor; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002627 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Advancing multimer analysis of von Willebrand factor by single-molecule AFM imaging. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002695 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynamic Force Spectroscopy Analysis on the Redox States of Protein Disulphide Bonds. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-002709 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Electrostatic Steering Enables Flow-Activated Von Willebrand Factor to Bind Platelet Glycoprotein, Revealed by Single-Molecule Stretching and Imaging. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-002719 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 4.6 Fast Force Loading Disrupts Molecular Binding Stability in Human and Mouse Cell Adhesions. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002814 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003141 SMASH-BIO | force_spectroscopy | study_record | in vitro Interaction of von Willebrand factor domains with collagen investigated by single molecule force spectroscopy. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003166 SMASH-BIO | force_spectroscopy | study_record | in vitro Long-ranged Protein-glycan Interactions Stabilize von Willebrand Factor A2 Domain from Mechanical Unfolding. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003189 SMASH-BIO | force_spectroscopy | study_record | in vitro Modular, ultra-stable, and highly parallel protein force spectroscopy in magnetic tweezers using peptide linkers · von Willebrand factor; magnetic tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003427 SMASH-BIO | force_spectroscopy | study_record | in vitro Biophysical approaches promote advances in the understanding of von Willebrand factor processing and function. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003507 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Flow-induced elongation of von Willebrand factor precedes tension-dependent activation. · von Willebrand factor; force spectroscopy unspecified; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003607 SMASH-BIO | force_spectroscopy | study_record | in vitro Mutual A domain interactions in the force sensing protein von Willebrand factor. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003913 SMASH-BIO | force_spectroscopy | study_record | in vitro Glycoprotein Ib-IX-V Complex Transmits Cytoskeletal Forces That Enhance Platelet Adhesion. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004046 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004056 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule force measurements of the polymerizing dimeric subunit of von Willebrand factor. · von Willebrand factor; afm smfs; experiment class: force_generation_polymerization, receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004129-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 200 pN | in vitro Adhesive Forces between A1 Domain of von Willebrand Factor and N-terminus Domain of Glycoprotein Ibα Measured by Atomic Force Microscopy. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004224 SMASH-BIO | force_spectroscopy | study_record | in vitro Force-Induced Unfolding of Leucine-Rich Repeats of Glycoprotein Ibα Strengthens Ligand Interaction. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004239 SMASH-BIO | force_spectroscopy | study_record | in vitro Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex. · von Willebrand factor; optical tweezers; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004422 SMASH-BIO | force_spectroscopy | study_record | in vitro Transport regulation of two-dimensional receptor-ligand association. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004435 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.7 Von Willebrand factor-A1 domain binds platelet glycoprotein Ibα in multiple states with distinctive force-dependent dissociation kinetics. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004447 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 A molten globule intermediate of the von Willebrand factor A1 domain firmly tethers platelets under shear flow. · von Willebrand factor; force spectroscopy unspecified; experiment class: force_generation_motor, receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004698 SMASH-BIO | force_spectroscopy | study_record | in vitro Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings. · von Willebrand factor; hydrodynamic stretching; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004933 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanisms by which von Willebrand disease mutations destabilize the A2 domain. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005056 SMASH-BIO | force_spectroscopy | study_record | in vitro The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα. · von Willebrand factor; biomembrane force probe; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005096 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 A rapid cloning method employing orthogonal end protection. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005124 SMASH-BIO | force_spectroscopy | study_record | in vitro Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding. · von Willebrand factor; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005442 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.2 Biology and physics of von Willebrand factor concatamers. · von Willebrand factor; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005448 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Calcium modulates force sensing by the von Willebrand factor A2 domain. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005606 SMASH-BIO | force_spectroscopy | study_record | in vitro Polymer-based catch-bonds. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005943 SMASH-BIO | force_spectroscopy | study_record | in vitro The catch bond mechanism between von Willebrand factor and platelet surface receptors investigated by molecular dynamics simulations. · von Willebrand factor; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005967-r2 SMASH-BIO | force_spectroscopy | velocity: 2000 nm/s | in vitro Unfolding the A2 domain of von Willebrand factor with the optical trap. · von Willebrand factor; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005967-r3 SMASH-BIO | force_spectroscopy | loading_rate: 22 pN/s | in vitro Unfolding the A2 domain of von Willebrand factor with the optical trap. · von Willebrand factor; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-006970 SMASH-BIO | force_spectroscopy | study_record | in vitro Dynamic force spectroscopy of glycoprotein Ib-IX and von Willebrand factor. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007145 SMASH-BIO | force_spectroscopy | study_record | in vitro Hydrodynamic forces applied on intercellular bonds, soluble molecules, and cell-surface receptors. · von Willebrand factor; hydrodynamic stretching; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007245 SMASH-BIO | force_spectroscopy | study_record | in vitro Cytoplasmic truncation of glycoprotein Ib alpha weakens its interaction with von Willebrand factor and impairs cell adhesion. · von Willebrand factor; optical tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007261 SMASH-BIO | force_spectroscopy | study_record | in vitro Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-007332 SMASH-BIO | force_spectroscopy | study_record | in vitro Binding strength and activation state of single fibrinogen-integrin pairs on living cells. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007407 SMASH-BIO | force_spectroscopy | study_record | in vitro Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers. · von Willebrand factor; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
Conflicts
No conflicts found among comparable evidence.
116 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.