Collagen alpha-1(I) chain
UniProt P02452 · gene COL1A1 · Homo sapiens · 1464 residues
147evidence items
0mapped to a state
0states
6techniques
4sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | cryoem | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|
| No states defined yet. | ||||||||
Unmapped evidence: 147 of 147 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 1 | 0 |
| RCSB PDB | 20 | 0 |
| SMASH-BIO | 125 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1Q7D-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -188.15 °C · pH 8 Structure of the integrin alpha2beta1 binding collagen peptide · collagen alfa 1(I) chain peptide GPOGPOGFOGERGPOGPOGPO (chains A,B,C) | unmapped |
| EV-PDB-2LLP-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.2 Solution structure of a THP type 1 alpha 1 collagen fragment (772-786) · Collagen alpha-1(I) chain (chains A,B,C) | unmapped |
| EV-PDB-3EJH-2 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6.5 · ligands GOL, NAG Crystal Structure of the Fibronectin 8-9FnI Domain Pair in Complex with a Type-I Collagen Peptide · Collagen type-I a1 chain (chains E,F) | unmapped |
| EV-PDB-3GXE-2 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL, NAG Complex of a Low Affinity Collagen Site with the Fibronectin 8-9FnI Domain Pair · Collagen alpha-1(I) chain (chains F) | unmapped |
| EV-PDB-3GXE-3 RCSB PDB | xray | resolution: 2.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL, NAG Complex of a Low Affinity Collagen Site with the Fibronectin 8-9FnI Domain Pair · Collagen alpha-1(I) chain (chains E) | unmapped |
| EV-PDB-5CTD-1 RCSB PDB | xray | resolution: 1.5991 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a2a1a1 of type I collagen · Collagen alpha-1(I) chain,Collagen alpha-1(IX) chain (chains A) | unmapped |
| EV-PDB-5CTD-3 RCSB PDB | xray | resolution: 1.5991 Å | in vitro · -173.15 °C · pH 7.5 Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a2a1a1 of type I collagen · Collagen alpha-1(I) chain,Collagen alpha-3(IX) chain (chains C) | unmapped |
| EV-PDB-5CTI-1 RCSB PDB | xray | resolution: 1.8994 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a2a1a1 of type I collagen (native form) · Collagen alpha-1(I) chain,Collagen alpha-1(IX) chain (chains A) | unmapped |
| EV-PDB-5CTI-3 RCSB PDB | xray | resolution: 1.8994 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a2a1a1 of type I collagen (native form) · Collagen alpha-1(I) chain,Collagen alpha-3(IX) chain (chains C) | unmapped |
| EV-PDB-5CVA-2 RCSB PDB | xray | resolution: 2.098 Å | in vitro · -173.15 °C · pH 6 · ligands GOL Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a1a2a1 of type I collagen · Collagen alpha-1(I) chain,Collagen alpha-2(IX) chain (chains B,E) | unmapped |
| EV-PDB-5CVA-3 RCSB PDB | xray | resolution: 2.098 Å | in vitro · -173.15 °C · pH 6 · ligands GOL Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a1a2a1 of type I collagen · Collagen alpha-1(I) chain,Collagen alpha-3(IX) chain (chains C,F) | unmapped |
| EV-PDB-5CVB-1 RCSB PDB | xray | resolution: 2.249 Å | in vitro · -173.15 °C · pH 6.4 · ligands GOL Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a1a1a1 of type I collagen · Collagen alpha-1(I) chain,Collagen alpha-1(IX) chain (chains A,D) | unmapped |
| EV-PDB-5CVB-2 RCSB PDB | xray | resolution: 2.249 Å | in vitro · -173.15 °C · pH 6.4 · ligands GOL Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a1a1a1 of type I collagen · Collagen alpha-1(I) chain,Collagen alpha-2(IX) chain (chains B,E) | unmapped |
| EV-PDB-5CVB-3 RCSB PDB | xray | resolution: 2.249 Å | in vitro · -173.15 °C · pH 6.4 · ligands GOL Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a1a1a1 of type I collagen · Collagen alpha-1(I) chain,Collagen alpha-3(IX) chain (chains C,F) | unmapped |
| EV-PDB-5K31-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands CA, CL, GOL Crystal structure of Human fibrillar procollagen type I C-propeptide Homo-trimer · Collagen alpha-1(I) chain (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-5OU8-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 6 · ligands CL, NAG, PG4 Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)5 · (GPO)5 (chains C,D,E) | unmapped |
| EV-PDB-5OU9-2 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 9 · ligands CL, NAG, PG4 Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)3 · (GPO)3 (chains C,D,E) | unmapped |
| EV-PDB-7E7B-1 RCSB PDB | cryoem | resolution: 2.6 Å | in vitro · ligands ELA, NAG, VCG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of the SARS-CoV-2 furin site mutant S-Trimer from a subunit vaccine candidate · Spike glycoprotein,Collagen alpha-1(I) chain (chains A,B,C) | unmapped |
| EV-PDB-7E7D-1 RCSB PDB | cryoem | resolution: 3.2 Å | in vitro · ligands ELA, NAG, branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Cryo-EM structure of the SARS-CoV-2 wild-type S-Trimer from a subunit vaccine candidate · Spike glycoprotein,Collagen alpha-1(I) chain (chains A,B,C) | unmapped |
| EV-PDB-8YV3-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C The heterotrimer structure of peptides derived from human collagen type I · Collagen alpha-1(I) chain (chains A,D) | unmapped |
| EV-BMRB-15986 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7.2 Chemical Shift Assignments of the Fibronectin 8-9FnI Domain Pair in Complex with a Type-I Collagen Peptide · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-P02452-F1 AlphaFold DB | af_prediction | plddt: 52.72 pLDDT | in silico AlphaFold DB prediction AF-P02452-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-1464 | unmapped |
| EV-SMASH-SMFS-000001 SMASH-BIO | force_spectroscopy | study_record | in vitro Streptococcus mutans Extracellular Vesicles Regulate Early Streptococcus sanguinis Nanoadhesion. · Collagen; afm smfs; experiment class: membrane_mechanics, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000129 SMASH-BIO | force_spectroscopy | study_record | in vitro How force drives pathogenicity: mechanoregulation of Streptococcus mutans adhesion to collagen. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000133 SMASH-BIO | force_spectroscopy | study_record | in vitro Hydration-mediated stabilization and anti-aggregation of soy and whey protein isolates, insulin, and collagen in hydrophilic deep eutectic solvents. · Collagen; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000136 SMASH-BIO | force_spectroscopy | study_record | in vitro Identification of missense variants in the C-domains of von Willebrand factor that cause gain-of-function-like activity. · Collagen; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000173 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.6 Matrix Mechanics Governs Mechano-Metabolic Adaptation across Cancer Grades in Bladder Spheroids. · Collagen; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-000341-r0 SMASH-BIO | force_spectroscopy | contour_length: 900 nm | in vitro · pH 7.6 Unraveling and Sliding of Polypeptide Strands Underlies the Exceptional Toughness of the Triple-Helix Collagen Molecule. · Collagen; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-000440 SMASH-BIO | force_spectroscopy | study_record | in vitro Enhancing osteoinduction: Collagen biogel enriched with piezoelectric barium titanate nanoparticles. · Collagen; force spectroscopy unspecified; experiment class: nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-000497 SMASH-BIO | force_spectroscopy | study_record | in vitro Matrix mechanics governs mechano-metabolic adaptation across cancer grades in bladder spheroids · Collagen; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-000521 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular characterization of an adhesion GPCR signal transduction · Collagen; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000532 SMASH-BIO | force_spectroscopy | study_record | in vitro Nanomechanics of cell-derived matrices as a functional read-out in collagen VI-related congenital muscular dystrophies. · Collagen; afm smfs; experiment class: force_generation_motor, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-000558 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling. · Collagen; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-000687-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 25.98 nN | in vitro Bacterial-host adhesion dominated by collagen subtypes remodeled by osmotic pressures · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000688-r0 SMASH-BIO | force_spectroscopy | adhesion_force: 25.98 nN | in vitro Bacterial-host adhesion dominated by collagen subtypes remodelled by osmotic pressure. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-000850 SMASH-BIO | force_spectroscopy | study_record | in vitro Micro-tensile rheology of fibrous gels quantifies strain-dependent anisotropy. · Collagen; optical tweezers; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-000868 SMASH-BIO | force_spectroscopy | study_record | in vitro Nanomechanics of cell-derived matrices as a functional read-out in Collagen VI-related Congenital Muscular Dystrophies · Collagen; afm smfs; experiment class: force_generation_motor, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-001256 SMASH-BIO | force_spectroscopy | study_record | in vitro Nanoscale Dynamics of Streptococcal Adhesion to AGE-Modified Collagen. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001257 SMASH-BIO | force_spectroscopy | study_record | in vitro Native extracellular matrix probes to target patient- and tissue-specific cell-microenvironment interactions by force spectroscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001270 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Papain-Based Solubilization of Decellularized Extracellular Matrix for the Preparation of Bioactive, Thermosensitive Pregels. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001410 SMASH-BIO | force_spectroscopy | study_record | in vitro Anisotropic 3D confinement of MCF-7 cells induces directed cell-migration and viscoelastic anisotropy of cell-membrane. · Collagen; optical tweezers; experiment class: force_generation_polymerization, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-001438 SMASH-BIO | force_spectroscopy | study_record | in vitro Cell mediated remodeling of stiffness matched collagen and fibrin scaffolds. · Collagen; optical tweezers; experiment class: force_generation_polymerization, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-001440 SMASH-BIO | force_spectroscopy | study_record | in vitro Cell-Specific Response of NSIP- and IPF-Derived Fibroblasts to the Modification of the Elasticity, Biological Properties, and 3D Architecture of the Substrate. · Collagen; afm smfs; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-001467 SMASH-BIO | force_spectroscopy | study_record | in vitro Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level. · Collagen; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001556 SMASH-BIO | force_spectroscopy | study_record | in vitro Instrument for tensile testing of individual collagen fibrils with facile sample coupling and uncoupling. · Collagen; magnetic tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-001605 SMASH-BIO | force_spectroscopy | study_record | in vitro Micromechanical remodeling of the extracellular matrix by invading tumors: anisotropy and heterogeneity. · Collagen; optical tweezers; experiment class: force_generation_motor, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-001634 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Nanomechanical and Morphological AFM Mapping of Normal Tissues and Tumors on Live Brain Slices Using Specially Designed Embedding Matrix and Laser-Shaped Cantilevers. · Collagen; afm smfs; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-001636 SMASH-BIO | force_spectroscopy | study_record | in vitro Nanoscale dynamics of streptococcal adhesion to AGE-modified collagen · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001638 SMASH-BIO | force_spectroscopy | study_record | in vitro Native extracellular matrix probes to target patient- and tissue- specific cell-microenvironment interactions by force spectroscopy · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-001735 SMASH-BIO | force_spectroscopy | study_record | in vitro Stiffness-Matched Extracellular Matrices Comprising Collagen or Fibrin Differentially Affect Cell-Mediated Remodeling and Peri-Cellular Stiffness · Collagen; optical tweezers; experiment class: force_generation_polymerization, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-001779 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.2 Understanding the Adhesion Mechanism of Hydroxyapatite-Binding Peptide. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-001953 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 How stable are the collagen and ferritin proteins for application in bioelectronics? · Collagen; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-001972 SMASH-BIO | force_spectroscopy | study_record | in vitro Integrin α2β1 as a negative regulator of the laminin receptors α6β1 and α6β4. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-001999 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-002220 SMASH-BIO | force_spectroscopy | study_record | in vitro A comparative analysis of detachment forces and energies in initial and mature cell-material interaction. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002233 SMASH-BIO | force_spectroscopy | study_record | in vitro Adhesion of Epithelial Cells to PNIPAm Treated Surfaces for Temperature-Controlled Cell-Sheet Harvesting. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002294 SMASH-BIO | force_spectroscopy | study_record | in vitro Dermal fibroblasts and triple-negative mammary epithelial cancer cells differentially stiffen their local matrix. · Collagen; optical tweezers; experiment class: force_generation_polymerization, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-002331 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Environmentally controlled magnetic nano-tweezer for living cells and extracellular matrices. · Collagen; magnetic tweezers; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-002387 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7 Inadequate tissue mineralization promotes cancer cell attachment. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002394 SMASH-BIO | force_spectroscopy | study_record | in vitro Integration of Magnetic Tweezers and Traction Force Microscopy for the Exploration of Matrix Rheology and Keratinocyte Mechanobiology: Model Force- and Displacement-Controlled Experiments · Collagen; magnetic tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-002477 SMASH-BIO | force_spectroscopy | study_record | in vitro Optical Tweezers Approaches for Probing Multiscale Protein Mechanics and Assembly. · Collagen; optical tweezers; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-002576 SMASH-BIO | force_spectroscopy | study_record | in vitro The human Descemet's membrane and lens capsule: Protein composition and biomechanical properties. · Collagen; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002656 SMASH-BIO | force_spectroscopy | study_record | in vitro Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus. · Collagen; afm smfs; experiment class: chromatin_mechanics, nucleic_acid_protein_interaction, rheology_cell | unmapped |
| EV-SMASH-SMFS-002708 SMASH-BIO | force_spectroscopy | study_record | in vitro Electron Transport in Muscle Protein Collagen. · Collagen; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002792 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanics and structural stability of the collagen triple helix. · Collagen; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-002842 SMASH-BIO | force_spectroscopy | study_record | in vitro Pilus-1 Backbone Protein RrgB of Streptococcus pneumoniae Binds Collagen I in a Force-Dependent Way. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-002870 SMASH-BIO | force_spectroscopy | study_record | in vitro Regulating substrate mechanics to achieve odontogenic differentiation for dental pulp stem cells on TiO2 filled and unfilled polyisoprene. · Collagen; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-002945 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 4 The predominant roles of the sequence periodicity in the self-assembly of collagen-mimetic mini-fibrils. · Collagen; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003019 SMASH-BIO | force_spectroscopy | study_record | in vitro Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential. · Collagen; optical tweezers; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-003025 SMASH-BIO | force_spectroscopy | study_record | in vitro Cell contraction induces long-ranged stress stiffening in the extracellular matrix. · Collagen; optical tweezers; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-003141 SMASH-BIO | force_spectroscopy | study_record | in vitro Interaction of von Willebrand factor domains with collagen investigated by single molecule force spectroscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003166 SMASH-BIO | force_spectroscopy | study_record | in vitro Long-ranged Protein-glycan Interactions Stabilize von Willebrand Factor A2 Domain from Mechanical Unfolding. · Collagen; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-003251 SMASH-BIO | force_spectroscopy | study_record | in vitro Quantifying effects of cyclic stretch on cell-collagen substrate adhesiveness of vascular endothelial cells. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003287 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-Molecule Assay for Proteolytic Susceptibility: Force-Induced Collagen Destabilization. · Collagen; centrifuge force; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003443 SMASH-BIO | force_spectroscopy | study_record | in vitro Comparison of ultrastructural and nanomechanical signature of platelets from acute myocardial infarction and platelet activation. · Collagen; afm smfs; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-003508 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices. · Collagen; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003601 SMASH-BIO | force_spectroscopy | study_record | in vitro Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. · Collagen; force spectroscopy unspecified; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-003712 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule assay for proteolytic susceptibility using centrifuge force microscopy:force-induced destabilization of collagen‘s triple helix · Collagen; centrifuge force; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-003728 SMASH-BIO | force_spectroscopy | study_record | in vitro Spatial distributions of pericellular stiffness in natural extracellular matrices are dependent on cell-mediated proteolysis and contractility. · Collagen; optical tweezers; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-003784 SMASH-BIO | force_spectroscopy | study_record | in vitro Unraveling capillary interaction and viscoelastic response in atomic force microscopy of hydrated collagen fibrils. · Collagen; afm smfs; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-003827 SMASH-BIO | force_spectroscopy | study_record | in vitro Atomic force microscopy reveals a dual collagen-binding activity for the staphylococcal surface protein SdrF. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003931 SMASH-BIO | force_spectroscopy | study_record | in vitro Intact Telopeptides Enhance Interactions between Collagens. · Collagen; optical tweezers; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-003953 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 Mechanical properties of the tumor stromal microenvironment probed in vitro and ex vivo by in situ-calibrated optical trap-based active microrheology. · Collagen; optical tweezers; experiment class: force_generation_polymerization, receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-003963 SMASH-BIO | force_spectroscopy | study_record | in vitro Methods for Determining the Cellular Functions of Vimentin Intermediate Filaments. · Collagen; optical tweezers; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-004066 SMASH-BIO | force_spectroscopy | study_record | in vitro Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-004119 SMASH-BIO | force_spectroscopy | study_record | in vitro A quantitative study of MC3T3-E1 cell adhesion, morphology and biomechanics on chitosan-collagen blend films at single cell level. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-004144 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Binding forces of Streptococcus mutans P1 adhesin. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004203 SMASH-BIO | force_spectroscopy | study_record | in vitro Energetic basis for the molecular-scale organization of bone. · Collagen; force spectroscopy unspecified; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-004247 SMASH-BIO | force_spectroscopy | study_record | in vitro In PC3 prostate cancer cells ephrin receptors crosstalk to β1-integrins to strengthen adhesion to collagen type I. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004292 SMASH-BIO | force_spectroscopy | study_record | in vitro Micromechanics of cellularized biopolymer networks. · Collagen; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-004302 SMASH-BIO | force_spectroscopy | study_record | in vitro Multiscale Investigation of the Depth-Dependent Mechanical Anisotropy of the Human Corneal Stroma. · Collagen; afm smfs; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-004365 SMASH-BIO | force_spectroscopy | study_record | in vitro Simple method to measure and analyze the fluctuations of a small particle in biopolymer solutions. · Collagen; optical tweezers; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-004411 SMASH-BIO | force_spectroscopy | study_record | in vitro The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks. · Collagen; force spectroscopy unspecified; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-004435 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 6.7 Von Willebrand factor-A1 domain binds platelet glycoprotein Ibα in multiple states with distinctive force-dependent dissociation kinetics. · Collagen; biomembrane force probe; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004520 SMASH-BIO | force_spectroscopy | study_record | in vitro Different roles of cadherins in the assembly and structural integrity of the desmosome complex. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004561 SMASH-BIO | force_spectroscopy | study_record | in vitro Hierarchical mechanics of connective tissues: integrating insights from nano to macroscopic studies. · Collagen; optical tweezers; experiment class: nucleic_acid_protein_interaction | unmapped |
| EV-SMASH-SMFS-004625 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Molecular adhesion between cartilage extracellular matrix macromolecules. · Collagen; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-004835 SMASH-BIO | force_spectroscopy | study_record | in vitro Delineating breast cancer cell interactions with engineered bone microenvironments. · Collagen; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004893 SMASH-BIO | force_spectroscopy | study_record | in vitro Investigating differential cell-matrix adhesion by directly comparative single-cell force spectroscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004916 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.4 Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004940 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 3.3 Microrheological characterization of collagen systems: from molecular solutions to fibrillar gels. · Collagen; optical tweezers; experiment class: force_generation_motor, rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-004942 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.6 Microstructural characterization of vocal folds toward a strain-energy model of collagen remodeling. · Collagen; afm smfs; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-004993 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing the interaction forces of prostate cancer cells with collagen I and bone marrow derived stem cells on the single cell level. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005008 SMASH-BIO | force_spectroscopy | study_record | in vitro Responsive biomimetic networks from polyisocyanopeptide hydrogels. · Collagen; afm smfs; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-005038 SMASH-BIO | force_spectroscopy | study_record | in vitro Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005090 SMASH-BIO | force_spectroscopy | study_record | in vitro β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005121 SMASH-BIO | force_spectroscopy | study_record | in vitro Biomechanics of the anterior human corneal tissue investigated with atomic force microscopy. · Collagen; afm smfs; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-005143 SMASH-BIO | force_spectroscopy | study_record | in vitro Conformational dynamics accompanying the proteolytic degradation of trimeric collagen I by collagenases. · Collagen; magnetic tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005253 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanotransduction through fibronectin-integrin focal adhesion in microvascular smooth muscle cells: is calcium essential? · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005260 SMASH-BIO | force_spectroscopy | study_record | in vitro Multiplexed single-molecule force proteolysis measurements using magnetic tweezers. · Collagen; optical tweezers; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005314 SMASH-BIO | force_spectroscopy | study_record | in vitro Revealing non-genetic adhesive variations in clonal populations by comparative single-cell force spectroscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005520 SMASH-BIO | force_spectroscopy | study_record | in vitro Glomerular podocytes: a study of mechanical properties and mechano-chemical signaling. · Collagen; magnetic tweezers; experiment class: force_generation_motor, receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-005558 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1. · Collagen; magnetic tweezers; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-005669 SMASH-BIO | force_spectroscopy | study_record | in vitro Structural and mechanical analysis of tectorial membrane Tecta mutants. · Collagen; force spectroscopy unspecified; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-005738 SMASH-BIO | force_spectroscopy | study_record | in vitro Characterization of the mechanical properties of the coronary sinus for percutaneous transvenous mitral annuloplasty. · Collagen; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005770 SMASH-BIO | force_spectroscopy | study_record | in vitro Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome. · Collagen; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-005863 SMASH-BIO | force_spectroscopy | study_record | in vitro Nanomechanical properties of thin films of type I collagen fibrils. · Collagen; afm smfs; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-005896 SMASH-BIO | force_spectroscopy | study_record | in vitro Quantifying cellular adhesion to extracellular matrix components by single-cell force spectroscopy. · Collagen; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-005933 SMASH-BIO | force_spectroscopy | study_record | in vitro Structural and micromechanical characterization of type I collagen gels. · Collagen; optical tweezers; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-005945 SMASH-BIO | force_spectroscopy | study_record | in vitro The effect of unlocking RGD-motifs in collagen I on pre-osteoblast adhesion and differentiation. · Collagen; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006051 SMASH-BIO | force_spectroscopy | study_record | in vitro Force spectroscopy of hepatocytic extracellular matrix components. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006270 SMASH-BIO | force_spectroscopy | study_record | in vitro BCR/ABL expression of myeloid progenitors increases beta1-integrin mediated adhesion to stromal cells. · Collagen; afm smfs; experiment class: nucleic_acid_protein_interaction, receptor_ligand_adhesion, translation_transcription_replication | unmapped |
| EV-SMASH-SMFS-006337 SMASH-BIO | force_spectroscopy | study_record | in vitro Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006354 SMASH-BIO | force_spectroscopy | study_record | in vitro Influence of endodontic chemical treatment on Enterococcus faecalis adherence to collagen studied with laser scanning confocal microscopy and optical tweezers: a preliminary study. · Collagen; optical tweezers; experiment class: receptor_ligand_adhesion, rheology_cell | unmapped |
| EV-SMASH-SMFS-006485 SMASH-BIO | force_spectroscopy | study_record | in vitro TPA primes alpha2beta1 integrins for cell adhesion. · Collagen; afm smfs; experiment class: membrane_mechanics, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006519 SMASH-BIO | force_spectroscopy | study_record | in vitro Alpha-actinin-4 is required for normal podocyte adhesion. · Collagen; magnetic tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006544 SMASH-BIO | force_spectroscopy | study_record | in vitro Contributions of galectin-3 and -9 to epithelial cell adhesion analyzed by single cell force spectroscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006574-r0 SMASH-BIO | force_spectroscopy | persistence_length: 16 nm | in vitro Entropic elasticity controls nanomechanics of single tropocollagen molecules. · Collagen; optical tweezers; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-006687 SMASH-BIO | force_spectroscopy | study_record | in vitro Revealing early steps of alpha2beta1 integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy. · Collagen; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006711 SMASH-BIO | force_spectroscopy | study_record | in vitro Structure and reactivity of adsorbed fibronectin films on mica. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion, rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-006713 SMASH-BIO | force_spectroscopy | study_record | in vitro Studying integrin-mediated cell adhesion at the single-molecule level using AFM force spectroscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006828-r0 SMASH-BIO | force_spectroscopy | rupture_force: 15 pN | in vitro Interactions between collagen IX and biglycan measured by atomic force microscopy. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006839 SMASH-BIO | force_spectroscopy | study_record | in vitro Measurement of the adhesive force between a single Klebsiella pneumoniae type 3 fimbria and collagen IV using optical tweezers. · Collagen; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006840-r0 SMASH-BIO | force_spectroscopy | elastic_modulus: 135 kPa ± 14 | in vitro Measurement of the mechanical properties of isolated tectorial membrane using atomic force microscopy. · Collagen; force spectroscopy unspecified; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-006871 SMASH-BIO | force_spectroscopy | study_record | in vitro Powering a burnt bridges Brownian ratchet: a model for an extracellular motor driven by proteolysis of collagen. · Collagen; force spectroscopy unspecified; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-006885 SMASH-BIO | force_spectroscopy | study_record | in vitro Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha. · Collagen; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-006963 SMASH-BIO | force_spectroscopy | study_record | in vitro Direct measurement of the rupture force of single pair of decorin interactions. · Collagen; optical tweezers; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007085 SMASH-BIO | force_spectroscopy | study_record | in vitro Topography and mechanical properties of single molecules of type I collagen using atomic force microscopy. · Collagen; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007137 SMASH-BIO | force_spectroscopy | study_record | in vitro Force spectroscopy of collagen fibers to investigate their mechanical properties and structural organization. · Collagen; afm smfs; experiment class: receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-007197-r0 SMASH-BIO | force_spectroscopy | persistence_length: 11.2 nm ± 8.4 | in vitro Single molecule mechanical properties of type II collagen and hyaluronan measured by optical tweezers. · Collagen; optical tweezers; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-007206-r0 SMASH-BIO | force_spectroscopy | persistence_length: 11.2 nm | in vitro Stretching type II collagen with optical tweezers. · Collagen; optical tweezers; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-007207 SMASH-BIO | force_spectroscopy | study_record | in vitro Structural changes in human type I collagen fibrils investigated by force spectroscopy. · Collagen; afm smfs; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-007333 SMASH-BIO | force_spectroscopy | study_record | in vitro Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium. · Collagen; force spectroscopy unspecified; experiment class: rheology_cell, unfolding_protein | unmapped |
| EV-SMASH-SMFS-007343-r0 SMASH-BIO | force_spectroscopy | persistence_length: 14.5 nm | in vitro Direct quantification of the flexibility of type I collagen monomer. · Collagen; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007343-r1 SMASH-BIO | force_spectroscopy | contour_length: 309 nm | in vitro Direct quantification of the flexibility of type I collagen monomer. · Collagen; force spectroscopy unspecified; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-007420 SMASH-BIO | force_spectroscopy | study_record | in vitro Cell traction forces on soft biomaterials. I. Microrheology of type I collagen gels. · Collagen; optical tweezers; experiment class: rheology_cell, rheology_material | unmapped |
| EV-SMASH-SMFS-007628 SMASH-BIO | force_spectroscopy | study_record | in vitro A method for determination of stiffness of collagen molecules. · Collagen; optical tweezers; experiment class: unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
147 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.