GTPase HRas
UniProt P01112 · gene HRAS · Homo sapiens · 189 residues
295evidence items
254mapped to a state
2states
7techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | neutron | nmr_structure | nmr_dynamics | nmr_shifts | af_prediction | md | Total |
|---|---|---|---|---|---|---|---|---|---|
| GDP-bound (inactive) Ras-GDP | observed | proc 42 | · | proc 4 | · | · | · | · | 46 |
| GTP-analogue-bound (active) Ras-GTP | observed | proc 204 | proc 1 | proc 3 | · | · | · | · | 208 |
Unmapped evidence: 41 of 295 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 7 | 0 |
| DisProt | 1 | 0 |
| MDDB | 1 | 0 |
| RCSB PDB | 285 | 254 |
Curated rules applied
ras-gdp: 45 itemsras-gtp-analogue: 207 items
Structure
Choose a state. Each model is badged observed or inferred; assumptions are one click away.
States and transitions
| State | Basis | Parent | Description |
|---|---|---|---|
| GDP-bound (inactive) Ras-GDP | observed | — | GDP-bound switch conformation, as in 4Q21. |
| GTP-analogue-bound (active) Ras-GTP | observed | — | GppNHp-bound active switch conformation, as in 5P21 (1.35 Å). State 1 and state 2 are not separated. |
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-10DC-1 RCSB PDB | xray | resolution: 2.08 Å | in vitro · -173.15 °C · ligands GNP, MG H-Ras GTPase R68A bound to GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-121P-1 RCSB PDB | xray | resolution: 1.54 Å | in vitro · ligands GCP, MG STRUKTUR UND GUANOSINTRIPHOSPHAT-HYDROLYSEMECHANISMUS DES C-TERMINAL VERKUERZTEN MENSCHLICHEN KREBSPROTEINS P21-H-RAS · H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1BKD-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · pH 8 COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1 · H-RAS (chains R) | unmapped |
| EV-PDB-1CRP-1 RCSB PDB | nmr_structure | structure | in vitro · ligands GDP, MG THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY · C-H-RAS P21 PROTEIN (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1CRQ-1 RCSB PDB | nmr_structure | structure | in vitro · ligands GDP, MG THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY · C-H-RAS P21 PROTEIN (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1CRR-1 RCSB PDB | nmr_structure | structure | in vitro · ligands GDP, MG THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY · C-H-RAS P21 PROTEIN (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1CTQ-1 RCSB PDB | xray | resolution: 1.26 Å | in vitro · -173.15 °C · pH 7.6 · ligands GNP, MG STRUCTURE OF P21RAS IN COMPLEX WITH GPPNHP AT 100 K · PROTEIN (TRANSFORMING PROTEIN P21/H-RAS-1) (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1GNQ-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 3.85 °C · ligands CAG, MG X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP · C-H-RAS P21 PROTEIN (chains A) | unmapped |
| EV-PDB-1GNR-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · 3.85 °C · ligands CAG, MG X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP · C-H-RAS P21 PROTEIN (chains A) | unmapped |
| EV-PDB-1HE8-2 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C · pH 6.3 · ligands GNP, MG Ras G12V - PI 3-kinase gamma complex · TRANSFORMING PROTEIN P21/H-RAS-1 (chains B) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1IAQ-1 RCSB PDB | xray | resolution: 2.9 Å | in vitro · 24.85 °C · pH 7.5 · ligands GNP, MG C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE · TRANSFORMING PROTEIN P21/H-RAS-1 (chains A,B,C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1IOZ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · pH 6.5 · ligands GDP Crystal Structure of the C-HA-RAS Protein Prepared by the Cell-Free Synthesis · TRANSFORMING PROTEIN P21/H-RAS-1 (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1JAH-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 3.85 °C · pH 7.5 · ligands GCP, MG H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM · C-HA-RAS (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1JAI-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 3.85 °C · pH 7.5 · ligands GCP, MN H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MANGANESE · C-HA-RAS (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1K8R-1 RCSB PDB | xray | resolution: 3 Å | in vitro · 16.85 °C · pH 8 · ligands GNP, MG Crystal structure of Ras-Bry2RBD complex · Transforming protein P21/H-RAS-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1LF0-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal Structure of RasA59G in the GTP-bound form · Transforming protein P21/H-RAS-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1LF5-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands GDP, MG Crystal Structure of RasA59G in the GDP-bound Form · Transforming protein P21/H-RAS-1 (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1LFD-2 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -181.15 °C · pH 6.5 · ligands GNP, MG CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS · RAS (chains B,D) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1NVV-2 RCSB PDB | xray | resolution: 2.18 Å | in vitro · -173.15 °C · pH 7.5 · ligands GNP, MG, PO4 Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS · Transforming protein p21/H-RAS-1 (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1NVV-1 RCSB PDB | xray | resolution: 2.18 Å | in vitro · -173.15 °C · pH 7.5 · ligands GNP, MG, PO4 Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS · Transforming protein p21/H-RAS-1 (chains Q) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1NVW-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands GNP, MG, PO4 Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS · Transforming protein p21/H-RAS-1 (chains Q,R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1NVX-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · pH 6.5 · ligands GTP, MG, PO4 Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS · Transforming protein p21/H-RAS-1 (chains Q,R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1P2T-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 24.85 °C · pH 7.6 · ligands GNP, MG H-Ras 166 in Aqueous mother liqour, RT · Transforming protein p21/H-RAS-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1P2U-1 RCSB PDB | xray | resolution: 2 Å | in vitro · ligands GNP, IPA, MG H-Ras in 50% isopropanol · Transforming protein p21/H-RAS-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1PLL-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · ligands GDP CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS · C-H-RAS P21 PROTEIN (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1Q21-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · ligands GDP, MG CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP · C-H-RAS P21 PROTEIN CATALYTIC DOMAIN (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1RVD-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 3.85 °C · pH 7.5 · ligands DBG, MG H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP · TRANSFORMING PROTEIN P21/H-RAS-1 (chains A) | unmapped |
| EV-PDB-1WQ1-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 3.85 °C · pH 8 · ligands AF3, GDP, MG RAS-RASGAP COMPLEX · H-RAS (chains R) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1XD2-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands GDP, MG, PO4 Crystal Structure of a ternary Ras:SOS:Ras*GDP complex · Transforming protein p21/H-Ras-1 (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1XD2-2 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands GDP, MG, PO4 Crystal Structure of a ternary Ras:SOS:Ras*GDP complex · Transforming protein p21/H-Ras-1 (chains B) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1XJ0-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 · ligands GDP, MG Crystal Structure of the GDP-bound form of the RasG60A mutant · Transforming protein p21/H-Ras-1 (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1ZW6-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal Structure of the GTP-bound form of RasQ61G · Transforming protein p21/H-Ras-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-221P-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · ligands GNP, MG THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES · H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2C5L-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · ligands GOL, GTP, MG Structure of PLC epsilon Ras association domain with hRas · GTPASE HRAS (chains A,B) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2CE2-1 RCSB PDB | xray | resolution: 1 Å | in vitro · -173.15 °C · pH 7.6 · ligands GDP, MG, XY2 CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GDP · GTPASE HRAS (chains X) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-2CL0-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7.6 · ligands GNP, MG, TRS, XY2 CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GppNHp · GTPASE HRAS (chains X) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2CL6-1 RCSB PDB | xray | resolution: 1.24 Å | in vitro · -173.15 °C · pH 7.6 · ligands CAG, MG, XY2 CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH S-caged GTP · GTPASE HRAS (chains X) | unmapped |
| EV-PDB-2CL7-1 RCSB PDB | xray | resolution: 1.25 Å | in vitro · -173.15 °C · pH 7.2 · ligands GTP, MG, XY2 CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP · GTPASE HRAS (chains X) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2CLC-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · pH 7.2 · ligands GTP, MG, XY2 CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP (2) · GTPASE HRAS (chains X) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-24SQ-1 RCSB PDB | xray | resolution: 1.08 Å | in vitro · -173.15 °C · ligands EDO, GDP, MG Human HRAS WT (GDP-bound) in complex with macrocyclic peptide inhibitor AP6296 · GTPase HRas, N-terminally processed (chains A,B) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1ZVQ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7.5 · ligands GDP, MG Structure of the Q61G mutant of Ras in the GDP-bound form · Transforming protein p21/H-Ras-1 (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-1XCM-1 RCSB PDB | xray | resolution: 1.84 Å | in vitro · -173.15 °C · pH 7 · ligands GNP, MG Crystal structure of the GppNHp-bound H-Ras G60A mutant · Transforming protein p21/H-Ras-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1QRA-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.6 · ligands GTP, MG STRUCTURE OF P21RAS IN COMPLEX WITH GTP AT 100 K · TRANSFORMING PROTEIN P21/H-RAS-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1PLK-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · ligands GTP, MG CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS · C-H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1PLJ-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · ligands CAG, MG CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS · C-H-RAS P21 PROTEIN (chains A) | unmapped |
| EV-PDB-1P2V-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · ligands GNP, HEZ, MG H-RAS 166 in 60 % 1,6 hexanediol · Transforming protein p21/H-RAS-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1P2S-1 RCSB PDB | xray | resolution: 2.45 Å | in vitro · -0.15 °C · pH 7.6 · ligands ETF, GNP, MG H-Ras 166 in 50% 2,2,2 triflouroethanol · Transforming protein p21/H-RAS-1 (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1NVU-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 7.5 · ligands GTP, MG, PO4 Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS · Transforming protein p21/H-RAS-1 (chains Q,R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1GNP-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · ligands AGN, MG X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP · C-H-RAS P21 PROTEIN (chains A) | unmapped |
| EV-PDB-1CLU-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 3.85 °C · pH 7.5 · ligands DBG, MG H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP · TRANSFORMING PROTEIN P21/H-RAS-1 (chains A) | unmapped |
| EV-PDB-1AGP-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · ligands GNP, MG THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS · C-H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-1AA9-1 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 5.5 · ligands GDP, MG HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE · C-HA-RAS (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-2EVW-1 RCSB PDB | xray | resolution: 1.05 Å | in vitro · -173.15 °C · pH 7.2 · ligands CAG, MG, XY2 Crystal structure analysis of a fluorescent form of H-Ras p21 in complex with R-caged GTP · GTPase HRas (chains X) | unmapped |
| EV-PDB-2LCF-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6.8 · ligands GNP, MG Solution structure of GppNHp-bound H-RasT35S mutant protein · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2LWI-1 RCSB PDB | nmr_structure | structure | in vitro · 4.85 °C · pH 6.8 · ligands GNP, KOB, MG Solution structure of H-RasT35S mutant protein in complex with Kobe2601 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2N42-1 RCSB PDB | nmr_structure | structure | in vitro EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data · GTPase HRas (chains A) | unmapped |
| EV-PDB-2N46-1 RCSB PDB | nmr_structure | structure | in vitro EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data · GTPase HRas (chains A) | unmapped |
| EV-PDB-2Q21-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · ligands GDP, MG CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP · C-H-RAS P21 PROTEIN CATALYTIC DOMAIN (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-2QUZ-1 RCSB PDB | xray | resolution: 1.49 Å | in vitro · -173.15 °C · pH 7.6 · ligands GDP, MG Crystal Structure of the activating H-RasK117R mutant in Costello Syndrome, bound to Mg-GDP · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-2RGA-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal structure of H-RasQ61I-GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2RGB-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal structure of H-RasQ61K-GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2RGC-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal structure of H-RasQ61V-GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2RGD-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal structure of H-RasQ61L-GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2RGE-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal structure of H-Ras-GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2RGG-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 7.5 · ligands GNP, MG Crystal structure of H-RasQ61I-GppNHp, trigonal crystal form · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2UZI-3 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · ligands GTP, MG, ZN Crystal structure of HRAS(G12V) - anti-RAS Fv complex · GTPASE HRAS (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2VH5-3 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 5.8 · ligands GTP, MG, ZN CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX · GTPASE HRAS (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2X1V-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.6 · ligands GDP Crystal Structure of the activating H-Ras I163F mutant in Costello Syndrome, bound to MG-GDP · GTPASE HRAS (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-3DDC-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 4.5 · ligands GNP, MG Crystal Structure of NORE1A in Complex with RAS · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3I3S-1 RCSB PDB | xray | resolution: 1.36 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal Structure of H-Ras with Thr50 replaced by Isoleucine · GTPase HRas (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3K8Y-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG Allosteric modulation of H-Ras GTPase · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3K9L-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Allosteric modulation of H-Ras GTPase · GTPase HRas (chains A,B,C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3K9N-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Allosteric modulation of H-Ras GTPase · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3KKN-1 RCSB PDB | xray | resolution: 2.09 Å | in vitro · -173.15 °C · pH 6.5 · ligands GNP, MG Crystal structure of H-Ras T35S in complex with GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3KUD-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · pH 6 · ligands GDP, MG Complex of Ras-GDP with RafRBD(A85K) · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-3L8Y-1 RCSB PDB | xray | resolution: 2.02 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG, YCN, ZN Complex of Ras with cyclen · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3L8Z-1 RCSB PDB | xray | resolution: 1.44 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG H-Ras wildtype new crystal form · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3LBH-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG Ras soaked in Calcium Acetate · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3LBI-1 RCSB PDB | xray | resolution: 2.087 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG Ras soaked in Magnesium Acetate and back soaked in Calcium Acetate · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3LBN-1 RCSB PDB | xray | resolution: 1.862 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Ras soaked in Magnesium Acetate · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3LO5-1 RCSB PDB | xray | resolution: 2.568 Å | in vitro · -173.15 °C · pH 7 · ligands CA, GDP, SO4 Crystal Structure of the dominant negative S17N mutant of Ras · GTPase HRas (chains A,C,E) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-3OIU-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG H-RasQ61L with allosteric switch in the "on" state · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3OIV-1 RCSB PDB | xray | resolution: 1.837 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DTT, GNP, MG H-RasG12V with allosteric switch in the "off" state · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3OIW-1 RCSB PDB | xray | resolution: 1.3 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG H-RasG12V with allosteric switch in the "on" state · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RRY-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG H-Ras crosslinked control, soaked in aqueous solution: one of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RRZ-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, GOL, MG H-Ras in 70% glycerol: one of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RS0-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG, YEG H-Ras soaked in neat cyclopentanol: one of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RS2-1 RCSB PDB | xray | resolution: 1.836 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, ETF, GNP, MG H-Ras soaked in 50% 2,2,2-trifluoroethanol: one of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RS4-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, HEZ, MG H-Ras soaked in 60% 1,6-hexanediol: 1 of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RS5-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DMF, GNP, MG H-Ras soaked in 55% dimethylformamide: 1 of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RS7-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG H-Ras soaked in 50% isopropanol: 1 of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RSL-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG, RSF H-Ras soaked in 90% R,S,R-bisfuranol: one of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RSO-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG, RSG H-Ras soaked in 20% S,R,S-bisfuranol: 1 of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3TGP-1 RCSB PDB | xray | resolution: 1.3075 Å | in vitro · 3.85 °C · pH 7.6 · ligands GNP, MG Room temperature H-ras · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-421P-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · ligands GNP, MG THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES · H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLR-1 RCSB PDB | xray | resolution: 1.319 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DTU, GNP, MG H-Ras PEG 400/Ca(OAc)2, ordered off · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLS-1 RCSB PDB | xray | resolution: 1.819 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG H-Ras Set 1 CaCl2 'Mixed' · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLT-1 RCSB PDB | xray | resolution: 1.699 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG H-Ras Set 2 Ca(OAc)2, on · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLU-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG H-Ras Set 1 Ca(OAc)2, on · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3RS3-1 RCSB PDB | xray | resolution: 1.52 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, HEX, MG H-Ras soaked in neat hexane: 1 of 10 in MSCS set · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-3KKM-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8.5 · ligands GNP, MG, SO4 Crystal structure of H-Ras T35S in complex with GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-2CLD-1 RCSB PDB | xray | resolution: 1.22 Å | in vitro · -173.15 °C · pH 7.2 · ligands GDP, MG CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GDP (2) · GTPASE HRAS (chains X) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-4G0N-1 RCSB PDB | xray | resolution: 2.45 Å | in vitro · -173.15 °C · pH 6.8 · ligands ACT, CA, DTU, GNP, MG Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4G3X-1 RCSB PDB | xray | resolution: 3.25 Å | in vitro · -173.15 °C · pH 6.8 · ligands GNP, MG Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4L9S-1 RCSB PDB | xray | resolution: 1.606 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GDP, MG, NA Crystal Structure of H-Ras G12C, GDP-bound · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-4NYJ-2 RCSB PDB | xray | resolution: 2.8522 Å | in vitro · -173.15 °C · pH 4 · ligands 2PZ, GNP, MG Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange · GTPase HRas (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4NYJ-1 RCSB PDB | xray | resolution: 2.8522 Å | in vitro · -173.15 °C · pH 4 · ligands 2PZ, GNP, MG Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange · GTPase HRas (chains Q) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4URY-1 RCSB PDB | xray | resolution: 2.47 Å | in vitro · -173.15 °C · ligands RV1 The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-5P21-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · ligands GNP, MG REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS · C-H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · curator:draft (unreviewed) · high GppNHp (GNP) bound, triphosphate conformation. |
| EV-PDB-5VBE-1 RCSB PDB | xray | resolution: 1.57 Å | in vitro · -173.15 °C · pH 7.7 · ligands 92V, GDP, MG Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GDP · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-5WPL-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · ligands CA, GNP, MG KRas G12V, bound to GppNHp and miniprotein 225-11 · GTPase HRas (chains A,D,G,J) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVI-3 RCSB PDB | xray | resolution: 1.746 Å | in vitro · -173.15 °C · pH 4 · ligands EC4, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVI-1 RCSB PDB | xray | resolution: 1.746 Å | in vitro · -173.15 °C · pH 4 · ligands EC4, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6AXG-2 RCSB PDB | xray | resolution: 3.302 Å | in vitro · -173.15 °C Structure of RasGRP4 in complex with HRas · GTPase HRas (chains B,D,F,H,J,L) | unmapped |
| EV-PDB-6AMB-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 8.9 · ligands GNP, MG Crystal Structure of the Afadin RA1 domain in complex with HRAS · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-621P-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · ligands GNP, MG THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES · H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5ZC6-1 RCSB PDB | nmr_structure | structure | in vitro · 4.85 °C · pH 6.8 · ligands GNP, KBF, MG Solution structure of H-RasT35S mutant protein in complex with KBFM123 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5X9S-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · ligands CA, GNP, MG Crystal structure of fully modified H-Ras-GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5WFR-1 RCSB PDB | xray | resolution: 2.46 Å | in vitro · -173.15 °C · pH 4 · ligands 5UW, GNP, MG Ligand-bound Ras:SOS:Ras complex · GTPase HRas (chains Q,R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5WFQ-1 RCSB PDB | xray | resolution: 2.26 Å | in vitro · -173.15 °C · pH 4 · ligands 5UV, GNP, MG Ligand-bound Ras:SOS:Ras complex · GTPase HRas (chains Q,R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5WFP-1 RCSB PDB | xray | resolution: 2.08 Å | in vitro · -173.15 °C · pH 4 · ligands 5UX, GNP, MG Ligand-bound Ras:SOS:Ras complex · GTPase HRas (chains Q,R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5WFO-1 RCSB PDB | xray | resolution: 1.99 Å | in vitro · -173.15 °C · pH 4 · ligands 5UU, GNP, MG Ligand-bound Ras:SOS:Ras complex · GTPase HRas (chains Q,R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5WDQ-1 RCSB PDB | xray | resolution: 1.25 Å | in vitro · -173.15 °C · ligands ACT, CA, GNP, MG, NA H-Ras mutant L120A bound to GMP-PNP at 100K · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5WDP-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · 3.85 °C · pH 6 · ligands CA, GNP, MG H-Ras mutant L120A bound to GMP-PNP at 277K · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5WDO-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · 3.85 °C · ligands CA, GNP, MG, NA H-Ras bound to GMP-PNP at 277K · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5VBZ-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6.6 · ligands 92V, GNP, MG Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp · GTPase HRas (chains A,B,C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5E95-2 RCSB PDB | xray | resolution: 1.402 Å | in vitro · -173.15 °C · pH 6.2 · ligands GDP, MG Crystal Structure of Mb(NS1)/H-Ras Complex · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-5B30-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 4.5 · ligands CA, GNP, MG, NA H-Ras WT in complex with GppNHp (state 1) after structural transition by humidity control · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-5B2Z-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · -173.15 °C · pH 4.5 · ligands CA, GNP, MG H-Ras WT in complex with GppNHp (state 2*) before structural transition by humidity control · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-521P-1 RCSB PDB | xray | resolution: 2.6 Å | in vitro · ligands GTP, MG THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES · H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4XVR-1 RCSB PDB | xray | resolution: 2.031 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG H-Ras Y137F · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4XVQ-1 RCSB PDB | xray | resolution: 1.887 Å | in vitro · -173.15 °C · pH 7.5 · ligands GNP, GOL, MG H-Ras Y137E · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4US2-1 RCSB PDB | xray | resolution: 2.48 Å | in vitro · -173.15 °C · ligands L7S The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-4US1-1 RCSB PDB | xray | resolution: 2.65 Å | in vitro · -173.15 °C · ligands L71 The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-4US0-1 RCSB PDB | xray | resolution: 2.17 Å | in vitro · -173.15 °C · ligands NEN The crystal structure of H-Ras and SOS in complex with ligands · GTPase HRas (chains R) | unmapped |
| EV-PDB-4URZ-1 RCSB PDB | xray | resolution: 2.24 Å | in vitro · -173.15 °C · ligands VJP The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-4URX-1 RCSB PDB | xray | resolution: 2.49 Å | in vitro · -173.15 °C · ligands FK1, FMT, HXY The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-4URW-1 RCSB PDB | xray | resolution: 2.76 Å | in vitro · -173.15 °C · ligands DXO The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-4URV-1 RCSB PDB | xray | resolution: 2.58 Å | in vitro · -173.15 °C · ligands FMT, UMK The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-4URU-1 RCSB PDB | xray | resolution: 2.83 Å | in vitro · -173.15 °C · ligands 6W2 The crystal structure of H-Ras and SOS in complex with ligands · GTPASE HRAS (chains R) | unmapped |
| EV-PDB-4RSG-1 RCSB PDB | neutron | resolution: 1.907 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG Neutron crystal structure of Ras bound to the GTP analogue GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4Q21-1 RCSB PDB | xray | resolution: 2 Å | in vitro · ligands GDP, MG MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS · C-H-RAS P21 PROTEIN CATALYTIC DOMAIN (chains A) | GDP-bound (inactive) · curator:draft (unreviewed) · high GDP and Mg2+ bound. |
| EV-PDB-4NYM-2 RCSB PDB | xray | resolution: 3.5529 Å | in vitro · -173.15 °C · pH 4.5 · ligands GNP, MG, RND Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange · GTPase HRas (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4NYM-1 RCSB PDB | xray | resolution: 3.5529 Å | in vitro · -173.15 °C · pH 4.5 · ligands GNP, MG, RND Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange · GTPase HRas (chains Q) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4NYI-2 RCSB PDB | xray | resolution: 2.9612 Å | in vitro · -173.15 °C · pH 4 · ligands 2PX, GNP, MG Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange · GTPase HRas (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4NYI-1 RCSB PDB | xray | resolution: 2.9612 Å | in vitro · -173.15 °C · pH 4 · ligands 2PX, GNP, MG Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange · GTPase HRas (chains Q) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4L9W-1 RCSB PDB | xray | resolution: 1.952 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, MG Crystal Structure of H-Ras G12C, GMPPNP-bound · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4K81-2 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 5.9 · ligands GOL, GTP, MG Crystal structure of the Grb14 RA and PH domains in complex with GTP-loaded H-Ras · GTPase HRas (chains B,D,F,H) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4EFN-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.5 · ligands GNP, MG Crystal structure of H-Ras Q61L in complex with GppNHp (state 1) · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4EFM-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands GNP, MG Crystal structure of H-Ras G12V in complex with GppNHp (state 1) · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4EFL-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands GNP, MG Crystal structure of H-Ras WT in complex with GppNHp (state 1) · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLZ-1 RCSB PDB | xray | resolution: 1.662 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DTU, GNP, MG H-Ras Set 2 Ca(OAc)2/DTE, ordered off · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLY-1 RCSB PDB | xray | resolution: 1.57 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DTT, GNP, MG Set 1 CaCl2/DTT, ordered off · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLX-1 RCSB PDB | xray | resolution: 1.731 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DTU, GNP, MG H-Ras Set 1 CaCl2/DTE, ordered off · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLW-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -173.15 °C · pH 7.5 · ligands ACT, CA, GNP, MG H-Ras Set 2 Ca(OAc)2/DTT, on · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-4DLV-1 RCSB PDB | xray | resolution: 1.572 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DTT, GNP, MG H-Ras Set 2 CaCl2/DTT, ordered off · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVJ-3 RCSB PDB | xray | resolution: 1.747 Å | in vitro · -173.15 °C · pH 4 · ligands EAS, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVJ-1 RCSB PDB | xray | resolution: 1.747 Å | in vitro · -173.15 °C · pH 4 · ligands EAS, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVK-3 RCSB PDB | xray | resolution: 1.799 Å | in vitro · -173.15 °C · ligands EAV, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVK-1 RCSB PDB | xray | resolution: 1.799 Å | in vitro · -173.15 °C · ligands EAV, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVL-3 RCSB PDB | xray | resolution: 1.748 Å | in vitro · -173.15 °C · pH 4 · ligands EBY, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVL-1 RCSB PDB | xray | resolution: 1.748 Å | in vitro · -173.15 °C · pH 4 · ligands EBY, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRAS (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVM-3 RCSB PDB | xray | resolution: 1.796 Å | in vitro · -173.15 °C · pH 4 · ligands EBV, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6BVM-1 RCSB PDB | xray | resolution: 1.796 Å | in vitro · -173.15 °C · pH 4 · ligands EBV, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6CUO-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 4 · ligands FFS, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6CUO-3 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 4 · ligands FFS, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6CUP-3 RCSB PDB | xray | resolution: 1.833 Å | in vitro · -173.15 °C · pH 4 · ligands FFV, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6CUP-1 RCSB PDB | xray | resolution: 1.833 Å | in vitro · -173.15 °C · pH 4 · ligands FFV, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6CUR-3 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 4 · ligands FFY, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6CUR-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 4 · ligands FFY, FMT, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D55-3 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, FWA, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D55-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, FWA, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D56-3 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, FVM, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D56-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, FVM, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D59-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 1 · ligands FMT, FVJ, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D59-3 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 1 · ligands FMT, FVJ, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5E-3 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 4 · ligands CL, FMT, FVG, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5E-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 4 · ligands CL, FMT, FVG, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5G-3 RCSB PDB | xray | resolution: 1.92 Å | in vitro · -173.15 °C · ligands BME, CL, FMT, FVD, GNP, GOL, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5G-1 RCSB PDB | xray | resolution: 1.92 Å | in vitro · -173.15 °C · ligands BME, CL, FMT, FVD, GNP, GOL, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5H-3 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands CL, FMT, FV7, GNP, GOL, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5H-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands CL, FMT, FV7, GNP, GOL, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5J-3 RCSB PDB | xray | resolution: 1.751 Å | in vitro · -173.15 °C · ligands FMT, FV4, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5J-1 RCSB PDB | xray | resolution: 1.751 Å | in vitro · -173.15 °C · ligands FMT, FV4, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5L-3 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands FMT, FW7, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5L-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands FMT, FW7, GNP, GOL, MG, NA Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5M-2 RCSB PDB | xray | resolution: 2.081 Å | in vitro · -173.15 °C · ligands FW4, GNP, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5M-1 RCSB PDB | xray | resolution: 2.081 Å | in vitro · -173.15 °C · ligands FW4, GNP, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains Q) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5V-2 RCSB PDB | xray | resolution: 2.04 Å | in vitro · -173.15 °C · ligands FVY, GNP, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5V-1 RCSB PDB | xray | resolution: 2.04 Å | in vitro · -173.15 °C · ligands FVY, GNP, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains Q) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5W-2 RCSB PDB | xray | resolution: 2.478 Å | in vitro · -173.15 °C · ligands FVV, GNP, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains R) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6D5W-1 RCSB PDB | xray | resolution: 2.478 Å | in vitro · -173.15 °C · ligands FVV, GNP, MG Ras:SOS:Ras in complex with a small molecule activator · GTPase HRas (chains Q) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6DZH-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, DTT, GDP, GOL, MG HRAS G13D bound to GDP (H13GDP) · GTPase HRas (chains A,B,C) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-6E6C-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -100 °C · pH 7.5 · ligands CA, GNP, MG HRAS G13D bound to GppNHp (H13GNP) · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6MQT-1 RCSB PDB | xray | resolution: 1.498 Å | in vitro · -173.15 °C · pH 8.5 · ligands GDP, MG HRAS G12S in complex with GDP · GTPase HRas (chains A,B,C,D,E,F,G,H) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-6NTC-1 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands GNP, GOL, MG Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 1 of CRAF Kinase protein · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6NTD-1 RCSB PDB | xray | resolution: 3.15 Å | in vitro · -173.15 °C · pH 5.6 · ligands GNP, MG Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 12 of CRAF Kinase protein · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6Q21-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · ligands GCP, MG MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS · C-H-RAS P21 PROTEIN CATALYTIC DOMAIN (chains A,B,C,D) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V94-3 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, GNP, GOL, MG, NA, QTV Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V94-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, GNP, GOL, MG, NA, QTV Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9F-3 RCSB PDB | xray | resolution: 1.849 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, GNP, GOL, MG, NA, QTS Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9F-1 RCSB PDB | xray | resolution: 1.849 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, GNP, GOL, MG, NA, QTS Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9J-3 RCSB PDB | xray | resolution: 1.76 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, GNP, GOL, MG, NA, QTM Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9J-1 RCSB PDB | xray | resolution: 1.76 Å | in vitro · -173.15 °C · pH 4 · ligands FMT, GNP, GOL, MG, NA, QTM Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9L-3 RCSB PDB | xray | resolution: 1.698 Å | in vitro · -173.15 °C · pH 4 · ligands ACT, FMT, GNP, GOL, MG, NA, QTJ Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9L-1 RCSB PDB | xray | resolution: 1.698 Å | in vitro · -173.15 °C · pH 4 · ligands ACT, FMT, GNP, GOL, MG, NA, QTJ Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9N-3 RCSB PDB | xray | resolution: 1.648 Å | in vitro · -173.15 °C · ligands FMT, GNP, GOL, MG, NA, QTD Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9N-1 RCSB PDB | xray | resolution: 1.648 Å | in vitro · -173.15 °C · ligands FMT, GNP, GOL, MG, NA, QTD Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9O-3 RCSB PDB | xray | resolution: 1.799 Å | in vitro · -173.15 °C · ligands FMT, GNP, GOL, MG, NA, QTA Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9O-1 RCSB PDB | xray | resolution: 1.799 Å | in vitro · -173.15 °C · ligands FMT, GNP, GOL, MG, NA, QTA Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6ZJ0-1 RCSB PDB | xray | resolution: 1.763 Å | in vitro · -173.15 °C · ligands EZZ, GCP, MG CRYSTAL STRUCTURE OF HRAS-G12D IN COMPLEX WITH GCP AND COMPOUND 18 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6ZL3-1 RCSB PDB | xray | resolution: 2.031 Å | in vitro · -173.15 °C · ligands EZZ, GDP, NA CRYSTAL STRUCTURE OF HRAS IN COMPLEX WITH COMPOUND 18 and GDP · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-721P-1 RCSB PDB | xray | resolution: 2 Å | in vitro · ligands GNP, MG THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES · H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7DPH-1 RCSB PDB | xray | resolution: 1.54 Å | in vitro · -173.15 °C · pH 5 · ligands GNP, MG, NA H-Ras Q61H in complex with GppNHp (state 1) after structural transition by humidity control · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7DPJ-1 RCSB PDB | xray | resolution: 1.976 Å | in vitro · -173.15 °C · ligands CA, GNP, MG H-Ras Q61L in complex with GppNHp (state 1) after structural transition by humidity control · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7JIF-1 RCSB PDB | xray | resolution: 1.757 Å | in vitro · -100 °C · pH 7.5 · ligands GNP, GOL, MG HRAS A59T GppNHp · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7JIG-1 RCSB PDB | xray | resolution: 2.322 Å | in vitro · -100 °C · pH 7.5 · ligands GNP, MG HRAS A59T GppNHp crystal 2 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7JII-1 RCSB PDB | xray | resolution: 1.532 Å | in vitro · -100 °C · pH 7.5 · ligands CA, GDP, MG HRAS A59E GDP · GTPase HRas (chains A,B) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-7L0F-1 RCSB PDB | xray | resolution: 1.98 Å | in vitro · -173.15 °C · ligands GSP, MG Monobody 12VC3 Bound to HRAS(WT) · GTPase HRas (chains A,E,G,L) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7L0G-1 RCSB PDB | xray | resolution: 2.54 Å | in vitro · -173.15 °C · ligands GSP, MG Monobody 12VC1 Bound to HRAS(G12C) · GTPase HRas (chains A,B,E,G) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7OG9-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG, PGE GTPase HRAS under ambient pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7OGA-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG, PGE GTPase HRAS under 200 MPa pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7OGB-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · 19.85 °C · pH 7.5 · ligands 1PE, GNP, MG, PGE GTPase HRAS under 500 MPa pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7OGC-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 19.85 °C · pH 7.5 · ligands 1PE, GNP, MG, PGE GTPase HRAS under 650 MPa pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7OGD-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG, PGE GTPase HRAS mutant D33K under ambient pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7OGE-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG, PGE GTPase HRAS mutant D33K under 200 MPa pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7JIH-1 RCSB PDB | xray | resolution: 1.989 Å | in vitro · -100 °C · pH 7.5 · ligands GNP, GOL, MG HRAS A59E GppNHp · GTPase HRas (chains A,B) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7JHP-1 RCSB PDB | xray | resolution: 2.766 Å | in vitro · -173.15 °C · ligands GNP, MG, ZN Crystal structure of HRas in complex with the Ras-binding and cysteine-rich domains of CRaf-kinase · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9M-3 RCSB PDB | xray | resolution: 1.648 Å | in vitro · -173.15 °C · ligands FMT, GNP, GOL, MG, NA, QTG Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6V9M-1 RCSB PDB | xray | resolution: 1.648 Å | in vitro · -173.15 °C · ligands FMT, GNP, GOL, MG, NA, QTG Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-6E6P-1 RCSB PDB | xray | resolution: 1.93 Å | in vitro · -173.15 °C · pH 7.5 · ligands CA, GNP, GOL, MG, NA HRAS G13D bound to GppNHp (Ha,b,c13GNP) · GTPase HRas (chains A,B,C) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8FG3-1 RCSB PDB | xray | resolution: 1.49 Å | in vitro · -173.15 °C · ligands GNP, MG HRAS R97L Crystal Form 2 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8TBG-1 RCSB PDB | xray | resolution: 1.2 Å | in vitro · -173.15 °C · pH 8 · ligands GNP, GOL, MG, ZNI Tricomplex of RMC-7977, HRAS WT, and CypA · GTPase HRas (chains A,B) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-9PUZ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8.7 · ligands GDP, MG, PO4 HRAS complex with UM0153030 compound · GTPase HRas (chains A,B,C) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9PVE-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 5.3 · ligands GDP HRAS complex with UM0152533 compound · GTPase HRas (chains A,B,C,D) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9WRU-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.4 · ligands GDP, GTP, MG SS-ROX structure analysis of H-Ras using caged-compound complex: freeze-trap series (5 hr after UV light irradiation) · GTPase HRas (chains A) | unmapped |
| EV-PDB-9WRT-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.4 · ligands GTP, MG SS-ROX structure analysis of H-Ras using caged-compound complex: freeze-trap series (2.5 h after UV light irradiation) · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-9WRS-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.4 · ligands GTP, MG SS-ROX structure analysis of H-Ras using caged-compound complex: freeze-trap series (within 15 min after UV light irradiation) · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-9WRR-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 24.85 °C · pH 6.4 · ligands CA, GDP, MG SS-ROX structure analysis of H-Ras using caged-compound complex: 28 hr after UV light irradiation (GDP bound form) · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9WRQ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6.4 · ligands CA, GTP, MG SS-ROX structure analysis of H-Ras using caged-compound complex: 15 min after UV light irradiation (GTP bound form state 1) · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-9WRP-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.4 · ligands CA, CAG, MG SS-ROX structure analysis of H-Ras using caged-compound complex: before UV light irradiation (NPE-caged GTP bound) · GTPase HRas (chains A) | unmapped |
| EV-PDB-9PUT-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 5.7 · ligands GDP, MG HRAS complex with UM0152535 compound · GTPase HRas (chains A,C) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9PUQ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 8.5 · ligands GDP, MG HRAS complex with UM0152248 compound · GTPase HRas (chains A,B,C) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9PUN-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 8.4 · ligands GDP, MG HRAS complex with UM0148697 compound · GTPase HRas (chains A,B,C) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9PUL-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · pH 8 · ligands GDP, MG HRAS complex with UM0143525 compound · GTPase HRas (chains A,B,C,D) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9PU8-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands GDP, MG HRAS complex with UM0140693 compound · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9PU3-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands GDP, MG HRAS complex with UM0140692 compound · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9PU1-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · ligands GDP, MG HRAS complex with UM0140401 compound · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-9P46-1 RCSB PDB | xray | resolution: 2.02 Å | in vitro · -173.15 °C · ligands A1CG4, GNP, MG Crystal structure of HRAS-G12D/Q95H (GMPPNP-bound) in complex with BBO-11818 · GTPase HRas (chains A,B) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8WWC-2 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · ligands GNP, MG De novo design binder of HRAS -120-4 · GTPase HRas (chains A,B) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8TLR-1 RCSB PDB | xray | resolution: 1.70004 Å | in vitro · -195.79 °C · pH 6.5 · ligands GDP, MG, MOV Crystal Structure of human HRAS G12C covalently bound to AMG 510 · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-8OSO-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG, PGE, YCN, ZN GTPase HRAS in complex with Zn-cyclen under 500 MPa pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8OSN-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG, PGE GTPASE HRAS IN COMPLEX WITH ZN-CYCLEN AT AMBIENT PRESSURE · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8OSM-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · 19.85 °C · pH 7.5 · ligands GNP, MG, PGE GTPASE HRAS IN COMPLEX WITH ZN-CYCLEN AT 200 MPA PRESSURE · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8FG4-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97L Crystal Form 1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8EM0-1 RCSB PDB | xray | resolution: 2.109 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97V Crystal Form 1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELZ-1 RCSB PDB | xray | resolution: 1.961 Å | in vitro · -173.15 °C · ligands CA, DTT, GNP, MG HRAS R97M Crystal Form 1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELY-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97M Crystal Form 2 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELX-1 RCSB PDB | xray | resolution: 1.975 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97I Crystal Form 1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELW-1 RCSB PDB | xray | resolution: 1.699 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97A Crystal Form 1 T-State · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELV-1 RCSB PDB | xray | resolution: 2.153 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97I Crystal Form 2 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELU-1 RCSB PDB | xray | resolution: 1.93 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97G Crystal form 1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELT-1 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97G Crystal Form 2 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELS-1 RCSB PDB | xray | resolution: 2.267 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97A Crystal Form 1 R-state · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELR-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · -173.15 °C · ligands CA, GNP, MG HRAS R97F Crystal Form 2 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8ELK-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · ligands CA, GNP, MG, NA HRAS R97F Crystal Form 1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-8CNN-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · ligands ACT, BEF, GDP, MG, PEG, SO4 BeF3 Phospho-HRas GSA complex · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-8CNJ-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · ligands BEF, GDP, MG, MPD HRas(1-166) in complex with GDP and BeF3- · GTPase HRas (chains A,B) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-8BWG-1 RCSB PDB | xray | resolution: 1.32 Å | in vitro · -173.15 °C · ligands GDP, MG, SO4 HRas (1-166) Y64 phosphorylation · GTPase HRas (chains R) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-8BOS-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 8 · ligands GAI, GDP, MG, MGF Transition state analogue complex of small G protein and its GAP effector · GTPase HRas (chains R) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-8BEA-1 RCSB PDB | xray | resolution: 2.47 Å | in vitro · -173.15 °C Crystal structure of SOS1-HRas-peptidomimetic10 · GTPase HRas (chains R) | unmapped |
| EV-PDB-8BE9-1 RCSB PDB | xray | resolution: 2.51 Å | in vitro · -173.15 °C · ligands CL, FMT Crystal structure of SOS1-HRas-peptidomimetic5 · GTPase HRas (chains R) | unmapped |
| EV-PDB-8BE8-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · ligands FMT Crystal structure of SOS1-HRas-peptidomimetic4 · GTPase HRas (chains R) | unmapped |
| EV-PDB-8BE7-1 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C Crystal structure of SOS1-HRas-peptidomimetic3 · GTPase HRas (chains R) | unmapped |
| EV-PDB-8BE6-1 RCSB PDB | xray | resolution: 2.8988 Å | in vitro · -173.15 °C Crystal structure of SOS1-HRas-peptidomimetic2 · GTPase HRas (chains R) | unmapped |
| EV-PDB-821P-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · ligands GNP, MG THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS · C-H-RAS P21 PROTEIN (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7VVG-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 5 · ligands GNP, MG Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7VV9-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 5 · ligands GNP, MG Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7VV8-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands GNP, MG Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-7TAM-1 RCSB PDB | xray | resolution: 1.87 Å | in vitro · -173.15 °C · pH 8 · ligands CA, GDP, MG HRas G12V in complex with GDP · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-PDB-7OGF-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 7.5 · ligands 1PE, GNP, MG, PGE GTPase HRAS mutant D33K under 900 MPa pressure · GTPase HRas (chains A) | GTP-analogue-bound (active) · rule:ras-gtp-analogue · high GTP or a non-hydrolysable analogue (GNP, GCP, GSP) bound. |
| EV-PDB-9WRV-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.4 · ligands GDP, GTP, MG SS-ROX structure analysis of H-Ras using caged-compound complex: freeze-trap series (10 hr after UV light irradiation) · GTPase HRas (chains A) | unmapped |
| EV-PDB-9WRW-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.4 · ligands GDP, GTP, MG SS-ROX structure analysis of H-Ras using caged-compound complex: freeze-trap series (20 hr after UV light irradiation) · GTPase HRas (chains A) | unmapped |
| EV-PDB-9WS9-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · 19.85 °C · pH 6.4 · ligands CA, CAG, MG SFX structure analysis of H-Ras using caged-GTP complex: dark condition (NPE-caged GTP bound) · GTPase HRas (chains A) | unmapped |
| EV-PDB-9Z5W-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.3 · ligands EDO, GDP Crystal structure of HRAS in complex with N-LHY affibody · GTPase HRas (chains A) | GDP-bound (inactive) · rule:ras-gdp · high GDP bound and no GTP analogue present. |
| EV-BMRB-10051 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 Backbone 1H and 15N assignment for the human c-Ha Ras (Y32W) in the GDP-bound state · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-17610 BMRB | nmr_dynamics | relaxation_rate | in vitro · 24.85 °C · pH 6.8 Solution structure of GppNHp-bound H-RasT35S mutant protein. · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts, T1 relaxation values, T2 relaxation values, heteronuclear NOE values | unmapped |
| EV-BMRB-17678 BMRB | nmr_shifts | chemical_shift | in vitro · 20 °C · pH 7.2 HRas166*GppNHp backbone chemical shift assignments · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18461 BMRB | nmr_dynamics | relaxation_rate | in vitro · 24.85 °C · pH 6.8 Chemical shift assignments and backbone dynamics of H-Ras-GppNHp bound to Ras-binding domain of cRaf1. · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts, heteronuclear NOE values, T1 relaxation values, T2 relaxation values | unmapped |
| EV-BMRB-18479 BMRB | nmr_shifts | chemical_shift | in vitro · 20 °C · pH 7.2 HRas166*GDP backbone chemical shift assignments · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18629 BMRB | nmr_shifts | chemical_shift | in vitro · 4.85 °C · pH 6.8 Solution structure of H-RasT35S mutant protein in complex with Kobe2601 · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36166 BMRB | nmr_shifts | chemical_shift | in vitro · 4.85 °C · pH 6.8 Solution structure of H-RasT35S mutant protein in complex with KBFM123 · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-DISPROT-DP00153r021 DisProt | xray | disorder_region: 20 residues | in vitro DisProt DP00153: disorder, residues 170-189 · residues 170-189; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-AFDB-AF-P01112-F1 AlphaFold DB | af_prediction | plddt: 91.94 pLDDT | in silico AlphaFold DB prediction AF-P01112-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-189 | unmapped |
| EV-MDDB-A00GQ MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 1GNR · start 1GNR; Amber Parm99 | unmapped |
Conflicts
No conflicts found among comparable evidence.
295 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.
Downloads
- Protein bundle (JSON)
- Ras-GDP-cif (mmCIF, observed)
- Ras-GDP-pdb (PDB, observed)
- Ras-GTP-cif (mmCIF, observed)
- Ras-GTP-pdb (PDB, observed)
- Curation file (YAML)