Thermonuclease
UniProt P00644 · gene nuc · Staphylococcus aureus · 231 residues
335evidence items
301mapped to a state
3states
5techniques
4sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|
| native, ligand-free SNase-apo | observed | proc 87 | proc 9 | · | · | · | 96 |
| native, Ca2+ and pdTp bound SNase-pdTp | observed | proc 197 | proc 2 | · | · | · | 199 |
| unfolded SNase-unfolded | inferred (one method) | · | · | proc 6 | · | · | 6 |
Unmapped evidence: 34 of 335 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 34 | 6 |
| RCSB PDB | 298 | 295 |
| SMASH-BIO | 2 | 0 |
Curated rules applied
snase-apo-structures: 95 itemssnase-denatured-nmr: 6 itemssnase-pdtp-bound: 198 items
Structure
Choose a state. Each model is badged observed or inferred; assumptions are one click away.
States and transitions
| State | Basis | Parent | Description |
|---|---|---|---|
| native, ligand-free SNase-apo | observed | — | Native fold of wild-type SNase without inhibitor, as in 1EY0 (1.6 Å). |
| native, Ca2+ and pdTp bound SNase-pdTp | observed | — | Ternary complex with Ca2+ and the inhibitor pdTp, as in 1SNC. |
| unfolded SNase-unfolded | inferred | — | Unfolded ensemble reached by denaturant, pressure or temperature. No observed structure.Assumptions (2)
|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1A2T-1 RCSB PDB | xray | resolution: 1.96 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, B-MERCAPTOETHANOL DISULFIDE TO V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1A2U-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, V23C VARIANT, COMPLEX WITH 1-N-BUTANE THIOL AND 3',5'-THYMIDINE DIPHOSPHATE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1A3U-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, CYCLOHEXANE THIOL DISULFIDE TO V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1A3V-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, CYCLOPENTANE THIOL DISULFIDE TO V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1ENA-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · ligands CA CRYSTAL STRUCTURES OF THE BINARY CA2+ AND PDTP COMPLEXES AND THE TERNARY COMPLEX OF THE ASP 21->GLU MUTANT OF STAPHYLOCOCCAL NUCLEASE. IMPLICATIONS FOR CATALYSIS AND LIGAND BINDING · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EY0-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF WILD-TYPE S. NUCLEASE AT 1.6 A RESOLUTION · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · curator:draft (unreviewed) · high Wild-type, ligand-free structure; representative of the apo state. |
| EV-PDB-1EY4-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF S. NUCLEASE STABILIZING MUTANT S59A · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EY5-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF S. NUCLEASE STABILIZING MUTANT T33V · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EY6-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF S. NUCLEASE STABILIZING MUTANT T41I · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EY7-1 RCSB PDB | xray | resolution: 1.88 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF S. NUCLEASE STABILIZING MUTANT S128A · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EY8-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF S. NUCLEASE STABILIZING TRIPLE MUTANT P117G/H124L/S128A · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EY9-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · 23.85 °C · pH 8 STRUCTURE OF S. NUCLEASE STABILIZING QUADRUPLE MUTANT T41I/P117G/H124L/S128A · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EYA-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 23.85 °C · pH 8 STRUCTURE OF S. NUCLEASE STABILIZING QUINTUPLE MUTANT T33V/T41I/P117G/H124L/S128A · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EYC-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · 23.85 °C · pH 8 STRUCTURE OF S. NUCLEASE STABILIZING QUINTUPLE MUTANT T41I/S59A/P117G/H124L/S128A · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EYD-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF WILD-TYPE S. NUCLEASE AT 1.7 A RESOLUTION · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EZ6-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF S. NUCLEASE STABILIZING SEXTUPLE MUTANT T33V/T41I/S59A/P117G/H124L/S128A · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EZ8-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · 23.85 °C · pH 7 STRUCTURE OF S. NUCLEASE STABILIZING MUTANT T33V · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1JOQ-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 5.5 · ligands THP Ensemble structures for Staphylococcal nuclease-H124L in ternary complex with Ca2+ and thymidine-3',5'-bisphosphate · staphylococcal nuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1KAA-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro STRESS AND STRAIN IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1KAB-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro STRESS AND STRAIN IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1KDA-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro STABILIZATION OF A STRAINED PROTEIN LOOP CONFORMATION THROUGH PROTEIN ENGINEERING · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1KDB-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro STABILIZATION OF A STRAINED PROTEIN LOOP CONFORMATION THROUGH PROTEIN ENGINEERING · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1NUC-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1RKN-1 RCSB PDB | nmr_structure | structure | in vitro · 31.85 °C · pH 4.9 Solution structure of 1-110 fragment of Staphylococcal Nuclease with G88W mutation · Thermonuclease (chains A) | unmapped |
| EV-PDB-1SNC-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · ligands CA, THP THE CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF STAPHYLOCOCCAL NUCLEASE, CA2+, AND THE INHIBITOR PD*TP, REFINED AT 1.65 ANGSTROMS · THERMONUCLEASE PRECURSOR (chains A) | native, Ca2+ and pdTp bound · curator:draft (unreviewed) · high Ca2+ and pdTp ternary complex; representative of the inhibitor-bound state. |
| EV-PDB-1SND-1 RCSB PDB | xray | resolution: 1.84 Å | in vitro STAPHYLOCOCCAL NUCLEASE DIMER CONTAINING A DELETION OF RESIDUES 114-119 COMPLEXED WITH CALCIUM CHLORIDE AND THE COMPETITIVE INHIBITOR DEOXYTHYMIDINE-3',5'-DIPHOSPHATE · STAPHYLOCOCCAL NUCLEASE DIMER (chains A,B) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1SNM-1 RCSB PDB | xray | resolution: 1.74 Å | in vitro · ligands CA, THP ACTIVE SITE MUTANT GLU-43 (RIGHT ARROW) ASP IN STAPHYLOCOCCAL NUCLEASE DISPLAYS NONLOCAL STRUCTURAL CHANGES · THERMONUCLEASE PRECURSOR (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1SNO-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 3.85 °C · pH 8.15 PROTEIN STABILITY IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1SNP-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · 3.85 °C · pH 8.15 PROTEIN STABILITY IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1SNQ-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 3.85 °C · pH 8.15 PROTEIN STABILITY IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1STA-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · ligands CA, THP ACCOMMODATION OF INSERTION MUTATIONS ON THE SURFACE AND IN THE INTERIOR OF STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1STG-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · ligands CO, THP TWO DISTINCTLY DIFFERENT METAL BINDING MODES ARE SEEN IN X-RAY CRYSTAL STRUCTURES OF STAPHYLOCOCCAL NUCLEASE-COBALT(II)-NUCLEOTIDE COMPLEXES · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1STH-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · ligands CO, THP TWO DISTINCTLY DIFFERENT METAL BINDING MODES ARE SEEN IN X-RAY CRYSTAL STRUCTURES OF STAPHYLOCOCCAL NUCLEASE-COBALT(II)-NUCLEOTIDE COMPLEXES · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1STN-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro THE CRYSTAL STRUCTURE OF STAPHYLOCOCCAL NUCLEASE REFINED AT 1.7 ANGSTROMS RESOLUTION · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1STY-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · ligands CA, THP THE ALPHA ANEURISM: A STRUCTURAL MOTIF REVEALED IN AN INSERTION MUTANT OF STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1STB-1 RCSB PDB | xray | resolution: 2 Å | in vitro · ligands CA, THP ACCOMMODATION OF INSERTION MUTATIONS ON THE SURFACE AND IN THE INTERIOR OF STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1NSN-3 RCSB PDB | xray | resolution: 2.8 Å | in vitro THE CRYSTAL STRUCTURE OF ANTIBODY N10-STAPHYLOCOCCAL NUCLEASE COMPLEX AT 2.9 ANGSTROMS RESOLUTION · STAPHYLOCOCCAL NUCLEASE (chains S) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1KDC-1 RCSB PDB | xray | resolution: 2 Å | in vitro STABILIZATION OF A STRAINED PROTEIN LOOP CONFORMATION THROUGH PROTEIN ENGINEERING · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1JOR-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 5.5 Ensemble structures for unligated Staphylococcal nuclease-H124L · staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1JOO-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 5.5 Averaged structure for unligated Staphylococcal nuclease-H124L · staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1JOK-1 RCSB PDB | nmr_structure | structure | in vitro · 44.85 °C · pH 5.5 · ligands THP Averaged structure for Staphylococcal nuclease-H124L in ternary complex with Ca2+ and thymidine-3',5'-bisphosphate · staphylococcal nuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1II3-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · 23.85 °C · pH 8 Structure of S. nuclease quintuple mutant V23I/V66L/I72L/I92L/V99L · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1IHZ-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · 23.85 °C · pH 8 Structure of S. nuclease mutant quintuple mutant V23L/V66L/I72L/I92L/V99L · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1F2Z-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 4.85 °C · pH 8.15 SIMPLIFICATION OF A PROTEIN LOOP IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1F2Y-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 4.85 °C · pH 8.15 SIMPLIFICATION OF A PROTEIN LOOP IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1F2M-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 4.85 °C · pH 8.15 SIMPLIFICATION OF A PROTEIN LOOP IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1EQV-1 RCSB PDB | xray | resolution: 1.94 Å | in vitro · 4.85 °C · pH 8.15 SIMPLIFICATION OF A PROTEIN LOOP IN STAPHYLOCOCCAL NUCLEASE · THERMONUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1ENC-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · ligands CA, THP CRYSTAL STRUCTURES OF THE BINARY CA2+ AND PDTP COMPLEXES AND THE TERNARY COMPLEX OF THE ASP 21->GLU MUTANT OF STAPHYLOCOCCAL NUCLEASE. IMPLICATIONS FOR CATALYSIS AND LIGAND BINDING · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1AEX-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, METHANE THIOL DISULFIDE TO V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1A3T-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, V23C VARIANT, COMPLEX WITH 2-FLUOROETHANE THIOL AND 3',5'-THYMIDINE DIPHOSPHATE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1TQO-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -178.15 °C · pH 6 Cryogenic Crystal Structure of Staphylococcal Nuclease Variant truncated Delta+PHS I92E · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1TR5-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 24.85 °C · pH 6 · ligands CA, THP Room temperature structure of Staphylococcal nuclease variant truncated Delta+PHS I92E · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2ENB-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · ligands THP CRYSTAL STRUCTURES OF THE BINARY CA2+ AND PDTP COMPLEXES AND THE TERNARY COMPLEX OF THE ASP 21->GLU MUTANT OF STAPHYLOCOCCAL NUCLEASE. IMPLICATIONS FOR CATALYSIS AND LIGAND BINDING · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2EXZ-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T22C · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EY1-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T22V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EY2-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T41C · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EY6-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T41V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EYJ-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T62V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EYM-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T120C · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EYP-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T120V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0D-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant I92V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0E-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V23L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0G-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V66I · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0I-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · pH 7.5 Crystal structure of Staphylococcal nuclease mutant I72L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0J-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant I72V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0L-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V23L/I72L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0M-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V23L/I72V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0O-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V66I/I72V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0P-1 RCSB PDB | xray | resolution: 2.05 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V66I/V99I · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0S-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V66L/I92V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0T-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V66L/V99I · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0U-1 RCSB PDB | xray | resolution: 1.83 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V23I/L25I/I72V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0V-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V23L/V66L/I72L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0W-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V23I/L25I/V66L/I72L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F3V-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 4.9 Solution structure of 1-110 fragment of staphylococcal nuclease with V66W mutation · Thermonuclease (chains A) | unmapped |
| EV-PDB-2F3W-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 6 solution structure of 1-110 fragment of staphylococcal nuclease in 2M TMAO · Thermonuclease (chains A) | unmapped |
| EV-PDB-2KHS-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 5 Solution structure of SNase121:SNase(111-143) complex · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2NUC-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHLOCOCCAL NUCLEASE, ETHANE THIOL DISULFIDE TO V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2OEO-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -178.15 °C · pH 6 · ligands CA, THP Cryogenic crystal structure of Staphylococcal Nuclease variant truncated Delta+PHS I92D · Staphylococcal thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2GSI-3 RCSB PDB | xray | resolution: 2.81 Å | in vitro · -173.15 °C · pH 5 · ligands NA Crystal Structure of a Murine Fab in Complex with an 11 Residue Peptide Derived from Staphylococcal Nuclease · Thermonuclease (chains W,X,Y,Z) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2FXZ-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 5 Solution structure of 97-109 segment of staphylococcal nuclease · 13-mer peptide from Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2FXY-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 5 Solution structure of 55-72 segment of staphylococcal nuclease · 18-mer peptide from Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0Q-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V66L/I92L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0N-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant L25I/I72L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0K-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V23I/L25I · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0H-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant V66L · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2F0F-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant L25I · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EYO-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T120S · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EYL-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T82S · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EYH-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T62S · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EYF-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · 19.85 °C Crystal structure of Staphylococcal nuclease mutant T44V · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2EY5-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 19.85 °C · pH 7.5 Crystal structure of Staphylococcal nuclease mutant T41S · Staphylococcal nuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1U9R-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 24.85 °C · pH 6.4 Crystal Structure of Staphylococcal Nuclease mutant V66E/P117G/H124L/S128A at Room Temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1TT2-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -178.15 °C · pH 8.1 · ligands CA, DMS, GOL, THP Cryogenic crystal structure of Staphylococcal nuclease variant truncated Delta+PHS I92K · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1SYG-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro ENGINEERING ALTERNATIVE BETA-TURN TYPES IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1SYF-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · ligands CA, THP ENGINEERING ALTERNATIVE BETA-TURN TYPES IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1SYE-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro ENGINEERING ALTERNATIVE BETA-TURN TYPES IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1SYD-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · ligands CA, THP ENGINEERING ALTERNATIVE BETA-TURN TYPES IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-1SYC-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro ENGINEERING ALTERNATIVE BETA-TURN TYPES IN STAPHYLOCOCCAL NUCLEASE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-1SYB-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · ligands CA, THP TRANSFER OF A BETA-TURN STRUCTURE TO A NEW PROTEIN CONTEXT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2OF1-1 RCSB PDB | xray | resolution: 1.92 Å | in vitro · -175.15 °C · pH 8 · ligands CA, DMS, THP Cryogenic crystal structure of the Staphylococcal Nuclease variant truncated Delta+PHS I92W · Staphylococcal thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2PQE-1 RCSB PDB | nmr_structure | structure | in vitro · 26.85 °C · pH 5 Solution structure of proline-free mutant of staphylococcal nuclease · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2QDB-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6 · ligands PO4 Crystal structure of staphylococcal nuclease variant E75Q/D21N/T33V/T41I/S59A/P117G/S128A at 100 K · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2RBM-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 8 · ligands CA, PO4, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I72K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2RDF-1 RCSB PDB | xray | resolution: 2.01 Å | in vitro · -173.15 °C · pH 6 · ligands PO4 Crystal Structure of staphyloccocal nuclease VIAGAN/E75A variant at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2RKS-1 RCSB PDB | xray | resolution: 2.01 Å | in vitro · -173.15 °C · pH 10.5 · ligands PO4 Crystal structure of Staphylococcal nuclease variant PHS L38K at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-2SNM-1 RCSB PDB | xray | resolution: 1.97 Å | in vitro · ligands CA, THP IN A STAPHYLOCOCCAL NUCLEASE MUTANT THE SIDE-CHAIN of A LYSINE REPLACING VALINE 66 IS FULLY BURIED IN THE HYDROPHOBIC CORE · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2SNS-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · ligands CA, THP STAPHYLOCOCCAL NUCLEASE. PROPOSED MECHANISM OF ACTION BASED ON STRUCTURE OF ENZYME-THYMIDINE 3(PRIME),5(PRIME)-BIPHOSPHATE-CALCIUM ION COMPLEX AT 1.5-ANGSTROMS RESOLUTION · THERMONUCLEASE PRECURSOR (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-2SOB-1 RCSB PDB | nmr_structure | structure | in vitro SN-OB, OB-FOLD SUB-DOMAIN OF STAPHYLOCOCCAL NUCLEASE, NMR, 10 STRUCTURES · STAPHYLOCOCCAL NUCLEASE (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-3BDC-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3D4D-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS Y91E at cryogenic temperature · Thermonuclease (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3E5S-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L103K at cryogenic temperature · Thermonuclease (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3EJI-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8 · ligands MPD, PO4 Crystal structure of Staphylococcal nuclease variant Delta+PHS L36K at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-3ERO-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I72E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3ERQ-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant L25K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3EVQ-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3HEJ-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands GOL, MPD, MRD, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62R at cryogenic temperature · Thermonuclease (chains A,B,C,D) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3ITP-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS F34K at cryogenic temperature · Nuclease A (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3MEH-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3MHB-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L38A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3MXP-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3MZ5-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L103A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3NHH-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant V23E-L36K at cryogenic temperature · Nuclease A (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3NK9-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V74A at cryogenic temperature · Nuclease A (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3NP8-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3NQT-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3NUC-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHLOCOCCAL NUCLEASE, 1-N-PROPANE THIOL DISULFIDE TO V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3NXW-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L125A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3OSO-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3P1H-1 RCSB PDB | xray | resolution: 1.79 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23K/I92A at cryogenic temperature · thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3PMF-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3QB3-1 RCSB PDB | xray | resolution: 1.63 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92KL25A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3SHL-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V74KL25A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3SK4-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 8 · ligands THP Crystal structure of Staphylococcal nuclease variant Delta+PHS D21N/V23E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3SK5-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V39D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3SK6-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands MRD, THP Crystal structure of Staphylococcal nuclease variant Delta+NVIAGLA V23K/L36E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3SK8-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7 · ligands MPD, PO4 Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G apo protein at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-3SR1-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS A69G bound to Ca2+ and thymidine-5',3'-diphosphate at cryogenic temperature · thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3S9W-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS M98G bound to Ca2+ and thymidine-5',3'-diphosphate at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3RUZ-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V74K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3P75-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 9.5 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V104D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3OWF-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 7 · ligands CA, PO4, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66R at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3LX0-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 6 · ligands PO4, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS D21N at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3HZX-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal Structure of Staphylococcal nuclease variant D+PHS/V66K at pH 9 determined at 100 K · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3H6M-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V104E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3DMU-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands MPD, PO4 Crystal structure of Staphylococcal nuclease variant PHS T62K at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-3DHQ-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS A90R at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3D6C-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant PHS L38E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3C1F-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V104K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3C1E-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L125K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3SXH-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92AL103A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3T13-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7 · ligands CA, MRD, PO4 Crystal structure of Staphylococcal nuclease variant Delta+PHS A69G at cryogenic temperature · Thermonuclease (chains A,B) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-3T16-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6 Crystal structure of Staphylococcal nuclease variant NVIAGA/M98G at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-3TME-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 8 · ligands MRD, THP Crystal structure of Staphylococcal nuclease variant Delta+NVIAGLA V23E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3TP5-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7 · ligands MPD, THP Crystal structure of Staphylococcal nuclease variant Delta+NVIAGLA V23E/L36E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3TP6-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36E/L103K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3TP7-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V99E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3U9O-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 6 · ligands PO4 Crystal structure of Staphylococcal nuclease variant NVIAGA/N100G at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-3V2T-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A/V66A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3VA5-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A/V23A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4DFA-1 RCSB PDB | xray | resolution: 1.404 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A/L36A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4DGZ-1 RCSB PDB | xray | resolution: 1.47 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A/L125A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4DU9-1 RCSB PDB | xray | resolution: 1.63 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A/V74A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4E6I-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 6 · ligands MPD, PO4 Crystal structure of Staphylococcal nuclease variant NVIAGA V99G at cryogenic temperature · Thermonuclease (chains A,B) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4EQN-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23E/I72K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4EQO-1 RCSB PDB | xray | resolution: 1.697 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V99D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4EVO-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -173.15 °C · pH 6 · ligands PO4 Crystal structure of Staphylococcal nuclease variant NVIAGA/E122G at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4F8M-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23I/I92V at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4HMI-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V99K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4HMJ-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4HTH-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 6 · ligands THP Crystal structure of Staphylococcal nuclease variant Delta+VIAGLA at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4IAL-1 RCSB PDB | xray | resolution: 1.595 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS H121E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4ID6-1 RCSB PDB | xray | resolution: 1.898 Å | in vitro · 24.85 °C · pH 8 Crystal Structure of Staphylococcal nuclease mutant V23I/I72L · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4IUN-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 7 · ligands CA, MPD, PO4, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS R126E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4IZ8-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS H8E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4J1M-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS R105E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4J6H-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS H121Q at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K14-1 RCSB PDB | xray | resolution: 1.601 Å | in vitro · 24.85 °C · pH 7.5 Crystal Structure of Staphylococcal nuclease mutant V66I/V99L · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4K2K-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25A/L36A/I92A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K2L-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92Q at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K5V-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23T/L36A/V99T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K5W-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 8 · ligands CA, MRD, PO4, THP Crystal structure of Staphylococcal nuclease variant V23M/L25F/T62F at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K5X-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 9 · ligands CA, MRD, PO4, THP Crystal structure of Staphylococcal nuclease variant V23M/L36F at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K6D-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 6 · ligands CA, MPD, PO4, THP Crystal structure of Staphylococcal nuclease variant V23M/T62F at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K8I-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 19.85 °C · pH 7 Crystal Structure of Staphylococcal Nuclease mutant I92V/V99L · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4KD3-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25A/V66A/I92A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KD4-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 8 · ligands CA, MRD, PO4, THP Crystal structure of Staphylococcal nuclease variant V23L/L25V/V66I/I72V at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KHV-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23S at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KJN-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23T/V66A/V99T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KJO-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36A/V66T/V99T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KTA-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS R105Q at cryogenic temperatures · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KV6-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS R126Q at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4K8J-1 RCSB PDB | xray | resolution: 2 Å | in vitro · 19.85 °C · pH 7 Crystal Structure of Staphylococcal nuclease mutant V23L/V66I · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4I65-1 RCSB PDB | xray | resolution: 1.61 Å | in vitro · 19.85 °C · pH 7 Crystal Structure of Staphylococcal nuclease mutant V23I/L25V/I72V/I92V · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4H7B-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · 19.85 °C · pH 7 Crystal Structure of Staphylococcal nuclease mutant I72V/V99L · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4G57-1 RCSB PDB | xray | resolution: 1.81 Å | in vitro · 26.85 °C · pH 8.4 Staphylococcal Nuclease double mutant I72L, I92L · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4F7X-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92A/L25A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4EQP-1 RCSB PDB | xray | resolution: 1.35 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I72D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4DF7-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23L/V99I at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-3TP8-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KY5-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D at pH 7 and cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KY6-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25D at pH 6 and cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4KY7-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V74D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4LAA-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4ME5-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23S/V66A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4MIU-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23T/V99T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4N9P-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23T/L25A/V99T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4N9T-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66A/I92S at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4NDX-1 RCSB PDB | xray | resolution: 1.496 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92N at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4NKL-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66A/I92Q at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4NMZ-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23Q/V66A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4NP5-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66A/I92N at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4ODG-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -173.15 °C · pH 9 · ligands CA, PO4, THP Crystal structure of Staphylococcal nuclease variant V23I/V66I/V74I/V99I at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4OL7-1 RCSB PDB | xray | resolution: 1.67 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66E A109E at cryogenic temperature · Thermonuclease (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4PMB-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylcoccal nuclease variant Delta+PHS I92S at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4PMC-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylcoccal nuclease variant Delta+PHS I72K V74K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4PNY-1 RCSB PDB | xray | resolution: 1.68 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I72H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4QB4-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · 19.85 °C · pH 7 Crystal Structure of Staphylococcal Nuclease mutant V23L/L25V/V66L · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-4QF4-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6 · ligands CA, PO4, THP Crystal structure of Staphylococcal nuclease variant V23M at cryogenic temperature · Thermonuclease (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4R8N-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 9 · ligands CA, MRD, PO4, THP Crystal structure of Staphylococcal nuclease variant V23I/V66I/I72V/I92V at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4RKB-1 RCSB PDB | xray | resolution: 1.88 Å | in vitro · 3.85 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66T/V99T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4RKL-1 RCSB PDB | xray | resolution: 1.66 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23T/V66T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4S3S-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92K/V23A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4TRD-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylcoccal nuclease variant Delta+PHS I72K/V74K at pH 9.0 at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4WOR-1 RCSB PDB | xray | resolution: 1.596 Å | in vitro · 24.85 °C · pH 8.15 · ligands CA, THP Staphylococcal nuclease in complex with Ca2+ and thymidine-3'-5'-diphosphate (pdTp) at room temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4YIJ-1 RCSB PDB | xray | resolution: 1.64 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylcoccal nuclease variant Delta+PHS A109E at cryogenic temperature · Nuclease A (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4ZQ3-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4ZUI-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-4ZUJ-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS Y91H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5C3W-1 RCSB PDB | xray | resolution: 1.72 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5C3X-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I72D/N100E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5C4H-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5C4Z-1 RCSB PDB | xray | resolution: 1.62 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5C5L-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -163.15 °C · pH 6 · ligands CA, PO4, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62E / L125E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5C5M-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62D / V104E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5C6A-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25E / N100E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CC4-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62E/V66E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CGK-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66D/N100E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CR3-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V104E/L125E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CV4-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/V66H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CV5-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS K64G/V66K/E67G at cryogenic temperature · Thermonuclease (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CV6-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66H/I92E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CV7-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66H/I92D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CV8-1 RCSB PDB | xray | resolution: 1.58 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/T62H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5CV9-1 RCSB PDB | xray | resolution: 1.62 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36E/V66H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5DAU-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V39E/V104E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5DEH-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS N100D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5E1F-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS G20E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5E3F-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5EGT-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5EKL-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62D/N100E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5F2D-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92N/V99T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5HUR-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25T/I92K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5I6W-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS A58D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5I6Y-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS A90E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IOC-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66H/V99D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5ISR-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L38E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5J1Z-1 RCSB PDB | xray | resolution: 1.73 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS A90D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5J22-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L103D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5JAV-1 RCSB PDB | xray | resolution: 1.895 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS Y91D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5JOB-1 RCSB PDB | xray | resolution: 1.45 Å | in vitro · -173.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25K/I92A at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5KEE-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25K/I92F at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5KRU-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -163.15 °C · pH 6 · ligands CA, PO4, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62E/V66K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5KYI-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62K/V66E pH 9 at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5NUC-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · 5 °C · pH 8.15 · ligands CA, THP STAPHYLOCOCCAL NUCLEASE, 1-N-PENTANE THIOL DISULFIDE TO V23C VARIANT · STAPHYLOCOCCAL NUCLEASE (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6B8R-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23K/L36Q at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6EEG-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylcoccal nuclease variant Delta+PHS T62E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6OK8-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -196.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS K127L at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6U0X-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · -196.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS Q123D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6XSB-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS A132S at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6XSC-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6XSE-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS F34Y at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6XSF-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -163.15 °C · pH 8 · ligands THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T41V at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6XSG-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6XSH-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62V at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6XSI-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V104T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-8K2R-2 RCSB PDB | nmr_structure | structure | in vitro · 36.85 °C · pH 7 The structure of HtpG M domain in complex with unstructured D131D binding site b · Disordered protein(D131D) (chains B) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-8K2T-2 RCSB PDB | nmr_structure | structure | in vitro · 36.85 °C · pH 7 Solution structure of full-length HtpG in complex with D131D · Nuclease A (chains C) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-9C11-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36R at cryogenic temperature · Nuclease A (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-9CU9-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/L36K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6U0W-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -196.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS K133M at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-6EEK-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -163.15 °C · pH 7 Crystal structure of apo Staphylcoccal nuclease variant Delta+PHS T62E/V66K, pH 7 at cryogenic temperature · Thermonuclease (chains A) | native, ligand-free · rule:snase-apo-structures · low Experimental structure without pdTp; variants (for example the Δ+PHS series) are still native folds. |
| EV-PDB-5KYL-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62K/V66E pH 7 at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5KIX-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I92E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5KGU-1 RCSB PDB | xray | resolution: 1.9 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS N118D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5K5P-1 RCSB PDB | xray | resolution: 1.83 Å | in vitro · -163.15 °C · pH 7 · ligands THP Crystal structure of Staphylococcal nuclease variant Delta+PHS I72K L103K at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IOD-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66H/V99E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IIF-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IGG-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V66H/I72E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IGF-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H/V66D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IGE-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H/V99D at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IGD-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 9 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H/I92E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IGC-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V23E/V66H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5IGB-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36D/V66H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5I9P-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5I9O-1 RCSB PDB | xray | resolution: 1.95 Å | in vitro · -163.15 °C · pH 7 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L36K L103K at cryogenic temperature · Thermonuclease (chains A,B) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5HGT-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -163.15 °C · pH 8 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS L25K/I92T at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-PDB-5EKK-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -163.15 °C · pH 6 · ligands CA, THP Crystal structure of Staphylococcal nuclease variant Delta+PHS V39D/L125E at cryogenic temperature · Thermonuclease (chains A) | native, Ca2+ and pdTp bound · rule:snase-pdtp-bound · high pdTp (ligand THP) bound in the active site. |
| EV-BMRB-136 BMRB | nmr_shifts | chemical_shift | in vitro · 35.85 °C · pH 7.6 NMR Signal Assignments of Amide Protons in the alpha-Helical Domains of Staphylococcal Nuclease · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-1581 BMRB | nmr_shifts | chemical_shift | in vitro · 36.85 °C · pH 6.4 Deletion of the omega-loop in the Active Site of Staphylococcal Nuclease 2. Effects on Protein Structure and Dynamics · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-1582 BMRB | nmr_shifts | chemical_shift | in vitro · 36.85 °C · pH 6.4 Deletion of the omega-loop in the Active Site of Staphylococcal Nuclease 2. Effects on Protein Structure and Dynamics · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-16585 BMRB | nmr_shifts | chemical_shift | in vitro · 26.85 °C · pH 5 Solution structure of SNase140 · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-1704 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.5 Two-Dimensional NMR Studies of Staphylococcal Nuclease: Evidence for Conformational Heterogeneity from Hydrogen-1, Carbon-13, and Nitrogen-15 Spin System Assignments of the Aromatic Amino Acids in the Nuclease H124L-Thymidine 3',5'-Bisphosp · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-18013 BMRB | nmr_shifts | chemical_shift | in vitro · 36.85 °C · pH 5.5 Staphylococcal Nuclease PHS variant · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-1874 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.1 Solution Studies of Staphylococcal Nuclease H124L. 2. 1H, 13C, and 15N Chemical Shift Assignments for the Unligated Enzyme and Analysis of Chemical Shift Changes That Accompany Formation of the Nuclease-Thymidine 3',5'-Bisphosphate-Calcium · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-1875 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.5 Solution Studies of Staphylococcal Nuclease H124L. 2. 1H, 13C, and 15N Chemical Shift Assignments for the Unligated Enzyme and Analysis of Chemical Shift Changes That Accompany Formation of the Nuclease-Thymidine 3',5'-Bisphosphate-Calcium · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-1876 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.5 Solution Studies of Staphylococcal Nuclease H124L. 2. 1H, 13C, and 15N Chemical Shift Assignments for the Unligated Enzyme and Analysis of Chemical Shift Changes That Accompany Formation of the Nuclease-Thymidine 3',5'-Bisphosphate-Calcium · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-1877 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.1 Solution Studies of Staphylococcal Nuclease H124L. 2. 1H, 13C, and 15N Chemical Shift Assignments for the Unligated Enzyme and Analysis of Chemical Shift Changes That Accompany Formation of the Nuclease-Thymidine 3',5'-Bisphosphate-Calcium · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-1878 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.5 Solution Studies of Staphylococcal Nuclease H124L. 2. 1H, 13C, and 15N Chemical Shift Assignments for the Unligated Enzyme and Analysis of Chemical Shift Changes That Accompany Formation of the Nuclease-Thymidine 3',5'-Bisphosphate-Calcium · BMRB data: 15N chemical shifts | unmapped |
| EV-BMRB-18788 BMRB | nmr_shifts | chemical_shift | in vitro · 31.85 °C · pH 6.6 Solution structure of staphylococcal nuclease E43S mutant in the presence of ssDNA and Cd2+ · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-188 BMRB | nmr_shifts | chemical_shift | in vitro · 35.85 °C · pH 7.6 NMR Signal Assignments of Amide Protons in the alpha-Helical Domains of Staphylococcal Nuclease · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-189 BMRB | nmr_shifts | chemical_shift | in vitro · 35.85 °C · pH 7.6 NMR Signal Assignments of Amide Protons in the alpha-Helical Domains of Staphylococcal Nuclease · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-2784 BMRB | nmr_shifts | chemical_shift | in vitro · 36.85 °C · pH 7 Dynamics of Methyl Groups in Proteins As Studied by Proton-Detected 13C NMR Spectroscopy. Application to the Leucine Residues of Staphylococcal Nuclease · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-2785 BMRB | nmr_shifts | chemical_shift | in vitro · 36.85 °C · pH 7 Dynamics of Methyl Groups in Proteins As Studied by Proton-Detected 13C NMR Spectroscopy. Application to the Leucine Residues of Staphylococcal Nuclease · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-36582 BMRB | nmr_shifts | chemical_shift | in vitro · 36.85 °C · pH 7 Solution structure of full-length HtpG in complex with D131D · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-4010 BMRB | nmr_shifts | chemical_shift | in vitro · 31.85 °C · pH 4.7 Resonance Assignments for the OB-fold Sub-Domain of Staphylococcal Nuclease (SNOB) -> Nuclease 1-103 (V66L, G88V) · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-4052 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.1 Solution structures of Staphylococcal Nuclease from multidimensional, multinuclear NMR: nuclease-H124L and its ternary complex with Ca2+ and Thymidine-3'-5'-bisphosphate · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-4053 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.1 Solution structures of Staphylococcal Nuclease from multidimensional, multinuclear NMR: nuclease-H124L and its ternary complex with Ca2+ and Thymidine-3'-5'-bisphosphate · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-4905 BMRB | nmr_shifts | chemical_shift | in vitro · 31.85 °C · pH 4.9 1H, 13C and 15N Chemical Shift Assignments for Urea-denatured G88W-110 Fragment of Staphylococcal Nuclease · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts | unfolded · rule:snase-denatured-nmr · medium NMR data titled as unfolded or denatured. |
| EV-BMRB-494 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.1 Two-Dimensional NMR Studies of Staphylococcal Nuclease. 1. Sequence-Specific Assignments of Hydrogen-1 Signals and Solution Structure of the Nuclease H124L-Thymidine 3',5'-Bisphosphate-Ca2+ Ternary Complex · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-495 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.5 Two-Dimensional NMR Studies of Staphylococcal Nuclease. 1. Sequence-Specific Assignments of Hydrogen-1 Signals and Solution Structure of the Nuclease H124L-Thymidine 3',5'-Bisphosphate-Ca2+ Ternary Complex · BMRB data: 1H chemical shifts | unmapped |
| EV-BMRB-496 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.1 Two-Dimensional NMR Studies of Staphylococcal Nuclease. 2. Sequence-Specific Assignments of Carbon-13 and Nitrogen-15 Signals from the Nuclease H124L-Thymidine 3',5'-Bisphosphate-Ca2+ Ternary Complex · BMRB data: 15N chemical shifts | unmapped |
| EV-BMRB-497 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.5 Two-Dimensional NMR Studies of Staphylococcal Nuclease. 2. Sequence-Specific Assignments of Carbon-13 and Nitrogen-15 Signals from the Nuclease H124L-Thymidine 3',5'-Bisphosphate-Ca2+ Ternary Complex · BMRB data: 13C chemical shifts | unmapped |
| EV-BMRB-530 BMRB | nmr_shifts | chemical_shift | in vitro · 44.85 °C · pH 5.5 Two-Dimensional NMR Studies of Staphylococcal Nuclease: Evidence for Conformational Heterogeneity from Hydrogen-1, Carbon-13, and Nitrogen-15 Spin System Assignments of the Aromatic Amino Acids in the Nuclease H124L-Thymidine 3',5'-Bisphosp · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-5536 BMRB | nmr_shifts | chemical_shift | in vitro · 31.85 °C · pH 4.9 1H, 13C, and 15N Chemical Shift Assignments for G88W110 fragment of Staphylococcal Nuclease · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts | unfolded · rule:snase-denatured-nmr · medium NMR data titled as unfolded or denatured. |
| EV-BMRB-6250 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 5 Backbone Chemical Shift Assignments for G88W121 fragment of Staphylococcal Nuclease · BMRB data: 1H chemical shifts, 15N chemical shifts, 13C chemical shifts | unfolded · rule:snase-denatured-nmr · medium NMR data titled as unfolded or denatured. |
| EV-BMRB-6251 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 5 Backbone Chemical Shift Assignments for V66W121 fragment of Staphylococcal Nuclease · BMRB data: 1H chemical shifts, 15N chemical shifts, 13C chemical shifts | unfolded · rule:snase-denatured-nmr · medium NMR data titled as unfolded or denatured. |
| EV-BMRB-644 BMRB | nmr_shifts | chemical_shift | in vitro · 36.85 °C · pH 7.4 Proline Assignments and Identification of the Cis K116/P117 Peptide Bond in Liganded Staphylococcal Nuclease Using Isotope Edited 2D NMR Spectroscopy · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-6907 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 4.9 Chemical Shift Assignments for V66W110 fragment of Staphylococcal Nuclease · BMRB data: 15N chemical shifts, 1H chemical shifts | unfolded · rule:snase-denatured-nmr · medium NMR data titled as unfolded or denatured. |
| EV-BMRB-6908 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6 1H, 13C, and 15N Chemical Shift Assignments for SNase110 fragment of Staphylococcal Nuclease in 2M TMAO · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unfolded · rule:snase-denatured-nmr · medium NMR data titled as unfolded or denatured. |
| EV-BMRB-7011 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 5 Solution structure of 97-109 segment of staphylococcal nuclease · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-7012 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 5 Solution structure of 55-72 segment of staphylococcal nuclease · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-P00644-F1 AlphaFold DB | af_prediction | plddt: 82.19 pLDDT | in silico AlphaFold DB prediction AF-P00644-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-231 | unmapped |
| EV-SMASH-SMFS-005535-r0 SMASH-BIO | force_spectroscopy | unfolding_force: 50 pN | in vitro Inhibitor binding increases the mechanical stability of staphylococcal nuclease. · Staphylococcal nuclease; afm smfs; experiment class: unfolding_protein | unmapped |
| EV-SMASH-SMFS-006422 SMASH-BIO | force_spectroscopy | study_record | in vitro Probing force-induced unfolding intermediates of a single staphylococcal nuclease molecule and the effect of ligand binding. · Staphylococcal nuclease; afm smfs; experiment class: receptor_ligand_adhesion, unfolding_protein | unmapped |
Conflicts
No conflicts found among comparable evidence.
335 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.
Downloads
- Protein bundle (JSON)
- SNase-apo-cif (mmCIF, observed)
- SNase-apo-pdb (PDB, observed)
- SNase-pdTp-cif (mmCIF, observed)
- SNase-pdTp-pdb (PDB, observed)
- Curation file (YAML)