Tyrosine-protein kinase ABL1
UniProt P00519 · gene ABL1 · Homo sapiens · 1130 residues
127evidence items
12mapped to a state
4states
5techniques
5sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_structure | nmr_shifts | af_prediction | md | Total |
|---|---|---|---|---|---|---|---|
| DFG-out inactive (type II inhibitor-bound) Abl-DFG-out | observed (one method) | proc 7 | · | · | · | · | 7 |
| active-like DFG-in (dasatinib-bound) Abl-active | observed (one method) | proc 2 | · | · | · | · | 2 |
| Src-like inactive Abl-Src-like-inactive | observed (one method) | proc 1 | · | · | · | · | 1 |
| autoinhibited (SH3-SH2 clamp, myristate-bound) Abl-autoinhibited | observed (one method) | proc 2 | · | · | · | · | 2 |
Unmapped evidence: 115 of 127 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 35 | 0 |
| DisProt | 5 | 0 |
| MDDB | 1 | 0 |
| RCSB PDB | 85 | 12 |
Curated rules applied
abl-dasatinib-active: 1 itemsabl-myristate-autoinhibited: 1 itemsabl-type2-dfg-out: 6 items
Ambiguous evidence (1)
Matched by rules for different states, so left unmapped for a curator to decide.
- EV-PDB-7N9G-1: rules abl-type2-dfg-out, abl-dasatinib-active point to DFG-out inactive (type II inhibitor-bound), active-like DFG-in (dasatinib-bound)
Structure
Choose a state. Each model is badged observed or inferred; assumptions are one click away.
States and transitions
| State | Basis | Parent | Description |
|---|---|---|---|
| DFG-out inactive (type II inhibitor-bound) Abl-DFG-out | observed | — | Kinase domain with DFG flipped out, bound to imatinib, as in 2HYY (human). Family vocabulary kinase: alpha_c: alpha_c_in, dfg: dfg_out |
| active-like DFG-in (dasatinib-bound) Abl-active | observed | — | Activated kinase domain bound to dasatinib, as in 2GQG. Family vocabulary kinase: alpha_c: alpha_c_in, dfg: dfg_in |
| Src-like inactive Abl-Src-like-inactive | observed | — | Src-like inactive kinase-domain conformation, as in 2G2I. Family vocabulary kinase: alpha_c: alpha_c_out, dfg: dfg_in |
| autoinhibited (SH3-SH2 clamp, myristate-bound) Abl-autoinhibited | observed | — | SH3 and SH2 domains clamped on the kinase with myristate in the C-lobe pocket, as in 2FO0. |
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-1BBZ-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -153.15 °C · pH 3.1 · ligands SO4 CRYSTAL STRUCTURE OF THE ABL-SH3 DOMAIN COMPLEXED WITH A DESIGNED HIGH-AFFINITY PEPTIDE LIGAND: IMPLICATIONS FOR SH3-LIGAND INTERACTIONS · ABL TYROSINE KINASE (chains A,C,E,G) | unmapped |
| EV-PDB-1ZZP-1 RCSB PDB | nmr_structure | structure | in vitro · 21.85 °C · pH 6.3 Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl · Proto-oncogene tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-2ABL-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · 19.85 °C · pH 7.5 SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE · ABL TYROSINE KINASE (chains A) | unmapped |
| EV-PDB-2HYY-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · ligands STI Human Abl kinase domain in complex with imatinib (STI571, Glivec) · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B,C,D) | DFG-out inactive (type II inhibitor-bound) · curator:draft (unreviewed) · high Human Abl kinase domain with imatinib (STI). |
| EV-PDB-2HZI-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · ligands JIN Abl kinase domain in complex with PD180970 · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-2V7A-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · ligands 627, MG Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358 · PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (chains A,B) | unmapped |
| EV-PDB-3K2M-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 8.5 · ligands PO4 Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-3PYY-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 8 · ligands 2PE, 3YY, GOL, SO4, STI Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site · Tyrosine-protein kinase ABL1 (chains A,B) | DFG-out inactive (type II inhibitor-bound) · rule:abl-type2-dfg-out · medium Imatinib (STI) or nilotinib (NIL) bound; type II inhibitors bind the DFG-out conformation. |
| EV-PDB-3QRI-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 8.2 · ligands 919, NA The crystal structure of human abl1 kinase domain in complex with DCC-2036 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-3QRJ-1 RCSB PDB | xray | resolution: 1.82 Å | in vitro · -173.15 °C · pH 7.1 · ligands 919 The crystal structure of human abl1 kinase domain T315I mutant in complex with DCC-2036 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-3QRK-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 8.2 · ligands 9DP The crystal structure of human abl1 kinase domain in complex with DP-987 · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-4TWP-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 7 · ligands AXI, NA, NI The crystal structure of human abl1 T315I gatekeeper mutant kinase domain in complex with axitinib · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-4XEY-1 RCSB PDB | xray | resolution: 2.891 Å | in vitro · -173.15 °C · pH 5 · ligands 1N1 Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase · Tyrosine-protein kinase ABL1 (chains A,B) | active-like DFG-in (dasatinib-bound) · rule:abl-dasatinib-active · medium Dasatinib (1N1) bound; it binds the active, DFG-in conformation. |
| EV-PDB-4WA9-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 7.4 · ligands AXI The crystal structure of human abl1 wild type kinase domain in complex with axitinib · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-4JJD-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 4 · ligands NA, PEG Crystal structure of the N114A Abl-SH3 domain mutant at pH4 · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-4JJC-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 5 · ligands PEG Crystal structure of the Abl-SH3 domain at pH5 · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-4JJB-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 3 · ligands PEG, SO4 Crystal structure of the Abl-SH3 domain at pH3 · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-4J9I-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 7 · ligands GOL Crystal structure of the ABL-SH3 domain complexed with the designed high-affinity peptide ligand P17 · Tyrosine-protein kinase ABL1 (chains A,C,E) | unmapped |
| EV-PDB-4J9H-1 RCSB PDB | xray | resolution: 1.7 Å | in vitro · -173.15 °C · pH 8 · ligands SO4 Crystal structure of the ABL-SH3 domain complexed with the designed high-affinity peptide ligand P7 at pH 8 · Tyrosine-protein kinase ABL1 (chains A,B,C,D,E,F) | unmapped |
| EV-PDB-4J9G-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 7 · ligands GOL, SO4 Crystal structure of the ABL-SH3 domain complexed with the designed high-affinity peptide ligand P7 at pH7 · Tyrosine-protein kinase ABL1 (chains A,C,E) | unmapped |
| EV-PDB-4J9F-1 RCSB PDB | xray | resolution: 1.094 Å | in vitro · -173.15 °C · pH 7 · ligands GOL, SO4 Crystal structure of the Abl-SH3 domain complexed with the high affinity peptide P0 · Tyrosine-protein kinase ABL1 (chains A,C,E) | unmapped |
| EV-PDB-4J9E-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 7 · ligands SO4 Crystal structure of the N114A mutant of the Abl-SH3 domain complexed with the high affinity peptide P17 · Tyrosine-protein kinase ABL1 (chains A,C,E) | unmapped |
| EV-PDB-4J9D-1 RCSB PDB | xray | resolution: 1.5 Å | in vitro · -173.15 °C · pH 6.5 · ligands SO4 Crystal structure of the N114A mutant of the Abl-SH3 domain complexed with the high affinity peptide P0 · Tyrosine-protein kinase ABL1 (chains A,C,E) | unmapped |
| EV-PDB-4J9C-1 RCSB PDB | xray | resolution: 1.051 Å | in vitro · -173.15 °C · pH 5.6 · ligands PEG, PGE Crystal structure of the Abl-SH3 domain H59Q-N96T mutant complexed with the designed high-affinity peptide ligand P17 · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-4J9B-1 RCSB PDB | xray | resolution: 1.702 Å | in vitro · -173.15 °C · pH 5.6 · ligands PEG Crystal structure of the Abl-SH3 domain H59Q-N96T mutant · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-3UYO-1 RCSB PDB | xray | resolution: 1.83 Å | in vitro · -173.15 °C · pH 5.5 · ligands SO4 Crystal structure of monobody SH13/ABL1 SH2 domain complex · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-3UE4-1 RCSB PDB | xray | resolution: 2.424 Å | in vitro · -196.15 °C · pH 5.5 · ligands DB8 Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the Abl tyrosine kinase domain · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-3T04-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · pH 6 · ligands GOL, SO4 Crystal structure of monobody 7c12/abl1 sh2 domain complex · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-3EGU-1 RCSB PDB | xray | resolution: 2.25 Å | in vitro · -173.15 °C · pH 7 · ligands GOL, SO4 Crystal structure of the N114A mutant of ABL-SH3 domain · Proto-oncogene tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-3EG3-1 RCSB PDB | xray | resolution: 1.4 Å | in vitro · -173.15 °C · pH 3 · ligands GOL Crystal structure of the N114A mutant of ABL-SH3 domain · Proto-oncogene tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-3EG2-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 3 · ligands GOL Crystal structure of the N114Q mutant of ABL-SH3 domain · Proto-oncogene tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-3EG1-1 RCSB PDB | xray | resolution: 1.85 Å | in vitro · -173.15 °C · pH 3.5 · ligands SO4 Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-3EG0-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 7 · ligands GOL Crystal structure of the N114T mutant of ABL-SH3 domain · Proto-oncogene tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-3CS9-1 RCSB PDB | xray | resolution: 2.21 Å | in vitro · -173.15 °C · pH 5.5 · ligands NIL Human ABL kinase in complex with nilotinib · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B,C,D) | DFG-out inactive (type II inhibitor-bound) · rule:abl-type2-dfg-out · medium Imatinib (STI) or nilotinib (NIL) bound; type II inhibitors bind the DFG-out conformation. |
| EV-PDB-2O88-1 RCSB PDB | xray | resolution: 1.75 Å | in vitro · -173.15 °C · pH 7 · ligands SO4 Crystal structure of the N114A mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-2HZ4-1 RCSB PDB | xray | resolution: 2.8 Å | in vitro · -173.15 °C · ligands 4ST Abl kinase domain unligated and in complex with tetrahydrostaurosporine · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B,C) | unmapped |
| EV-PDB-2HZ0-1 RCSB PDB | xray | resolution: 2.1 Å | in vitro · -173.15 °C · ligands GIN Abl kinase domain in complex with NVP-AEG082 · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-2HIW-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -73.15 °C · pH 5.5 · ligands 7MP Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-2GQG-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 6.5 · ligands 1N1, GOL X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | active-like DFG-in (dasatinib-bound) · curator:draft (unreviewed) · high Dasatinib bound to the activated kinase domain. |
| EV-PDB-2G2I-1 RCSB PDB | xray | resolution: 3.12 Å | in vitro · -173.15 °C · pH 8 · ligands ADP A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain · Abl Tyrosine Kinase (chains A,B) | Src-like inactive · curator:draft (unreviewed) · high Title: Src-like inactive conformation. |
| EV-PDB-2G2H-1 RCSB PDB | xray | resolution: 2 Å | in vitro · -173.15 °C · pH 3.5 · ligands P16 A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain · Abl Tyrosine (chains A,B) | unmapped |
| EV-PDB-2G2F-1 RCSB PDB | xray | resolution: 2.7 Å | in vitro · -173.15 °C · pH 5.5 · ligands 112, AGS A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain · Abl Kinase (chains A,B) | unmapped |
| EV-PDB-2G1T-1 RCSB PDB | xray | resolution: 1.8 Å | in vitro · -173.15 °C · pH 6.5 · ligands 112, MG A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B,C,D) | unmapped |
| EV-PDB-2FO0-1 RCSB PDB | xray | resolution: 2.27 Å | in vitro · -173.15 °C · pH 7.5 · ligands GOL, MYR, P16 Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase · Proto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM) (chains A) | autoinhibited (SH3-SH2 clamp, myristate-bound) · curator:draft (unreviewed) · medium SH3-SH2 unit with myristate; the entry covers active and inactive forms, so medium. |
| EV-PDB-2F4J-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -173.15 °C · pH 3.5 · ligands VX6 Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680 · Proto-oncogene tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-2E2B-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 6 · ligands 406 Crystal structure of the c-Abl kinase domain in complex with INNO-406 · Proto-oncogene tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-1OPL-1 RCSB PDB | xray | resolution: 3.42 Å | in vitro · -173.15 °C · pH 7 · ligands MYR, P16 Structural basis for the auto-inhibition of c-Abl tyrosine kinase · proto-oncogene tyrosine-protein kinase (chains A,B) | autoinhibited (SH3-SH2 clamp, myristate-bound) · rule:abl-myristate-autoinhibited · medium Myristate (MYR) in the C-lobe pocket marks the assembled, autoinhibited form. |
| EV-PDB-1JU5-3 RCSB PDB | nmr_structure | structure | in vitro · 29.85 °C · pH 6.8 Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy · Abl (chains C) | unmapped |
| EV-PDB-1AWO-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7.5 THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES · ABL TYROSINE KINASE (chains A) | unmapped |
| EV-PDB-1AB2-1 RCSB PDB | nmr_structure | structure | in vitro THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL · C-ABL TYROSINE KINASE SH2 DOMAIN (chains A) | unmapped |
| EV-PDB-5DC0-2 RCSB PDB | xray | resolution: 2.23 Å | in vitro · -173.15 °C · pH 8 CRYSTAL STRUCTURE OF MONOBODY GG3/ABL1 SH2 DOMAIN COMPLEX · Tyrosine-protein kinase ABL1 (chains B) | unmapped |
| EV-PDB-5DC9-1 RCSB PDB | xray | resolution: 1.56 Å | in vitro · -173.15 °C · pH 8.5 · ligands GOL, IMD CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL B · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-5OAZ-1 RCSB PDB | xray | resolution: 1.03 Å | in vitro · -173.15 °C · pH 7.5 · ligands PEG Crystal structure of the Abl-SH3 domain at pH 7.5 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-6AMV-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Abl 1b Regulatory Module 'inhibiting state' · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-6AMW-1 RCSB PDB | nmr_structure | structure | in vitro · 24.85 °C · pH 7 Abl1b Regulatory Module 'Activating' conformation · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-6XRG-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 7.7 Abl 1b isoform inactive2 state · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-7N9G-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · ligands 1N1, PO4, STI Crystal structure of the Abl 1b Kinase domain in complex with Dasatinib and Imatinib · Tyrosine-protein kinase ABL1 (chains A,B,C) | unmapped |
| EV-PDB-7PW2-1 RCSB PDB | xray | resolution: 1.1 Å | in vitro · -173.15 °C · pH 7 Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E mutant · Non-specific protein-tyrosine kinase (chains A) | unmapped |
| EV-PDB-9KS5-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 5 The crystal structure of ABL1 in complex with K-CNBA-1 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-8SSN-1 RCSB PDB | xray | resolution: 2.86 Å | in vitro · -173.15 °C · pH 8 · ligands AY7, CL, DMS, SKI, SO4 Abl kinase in complex with SKI and asciminib · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-8I7Z-1 RCSB PDB | xray | resolution: 2.25496 Å | in vitro · -173.15 °C · ligands 6CI, BAL The crystal structure of human abl1 kinase domain in complex with ABL1-B5 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-8I7T-1 RCSB PDB | xray | resolution: 2.80005 Å | in vitro · -173.15 °C · ligands 6I5 The crystal structure of human abl1 kinase domain in complex with ABL1-B4 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-8I7S-1 RCSB PDB | xray | resolution: 1.94635 Å | in vitro · -173.15 °C · ligands 6CI The crystal structure of human abl1 kinase domain in complex with ABL1-B1 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-8H7H-1 RCSB PDB | xray | resolution: 2.2779 Å | in vitro · -173.15 °C · ligands QH9 The crystal structure of human abl1 kinase domain in complex with abl1-A-EBA · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-8H7F-1 RCSB PDB | xray | resolution: 2.45013 Å | in vitro · -173.15 °C · ligands QEW The crystal structure of human abl1 kinase domain in complex with abl1-B-EBA · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-7W7Y-1 RCSB PDB | xray | resolution: 2.20003 Å | in vitro · -173.15 °C · ligands 8IW The crystal structure of human abl1 kinase domain in complex with ABL2-A5 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-7W7X-1 RCSB PDB | xray | resolution: 2.00001 Å | in vitro · -173.15 °C · ligands 8DW The crystal structure of human abl1 kinase domain in complex with ABL1-A11 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-7PVV-1 RCSB PDB | xray | resolution: 1.82 Å | in vitro · -173.15 °C · pH 5.5 · ligands PEG, PGE Crystal structure of the Abl SH3 domain G92N-Y93N-N94T-H95E mutant · Bcr-abl1 e6a2 chimeric protein (chains A) | unmapped |
| EV-PDB-7PVS-1 RCSB PDB | xray | resolution: 1.05 Å | in vitro · -173.15 °C · pH 6.5 · ligands NA, P6G, PEG, PGE, SO4 Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in presence of PEG 200 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-7PVR-1 RCSB PDB | xray | resolution: 1.65 Å | in vitro · -173.15 °C · pH 6 Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in the space group P41 · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-7PVQ-1 RCSB PDB | xray | resolution: 1.55 Å | in vitro · -173.15 °C · pH 6 Crystal structure of the Abl SH3 domain V73E-A74S-S75R-G76T-D77E-G92N-Y93N-N94T-H95E mutant in the space group P21221 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-7DT2-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 7 · ligands HJ9 Strategic design of catalytic lysine-targeting reversible covalent BCR-ABL Inhibitors · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-7CC2-1 RCSB PDB | xray | resolution: 2.723 Å | in vitro · -173.15 °C · ligands FVC Strategic design of catalytic lysine-targeting reversible covalent BCR-ABL Inhibitors · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-6XR7-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 6.5 Abl isoform 1b inactive1 state · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-6XR6-1 RCSB PDB | nmr_structure | structure | in vitro · 9.85 °C · pH 7.1 Abl 1b isoform active state · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-6NPV-1 RCSB PDB | xray | resolution: 1.86 Å | in vitro · -173.15 °C · ligands 2PE, GOL, KWP, SO4, STI C-abl Kinase domain with the activator(cmpd51), N-(1-(3,4-dichlorophenyl)-4-(2-hydroxyethyl)-4,5-dihydro-1H-pyrazol-3-yl)isonicotinamide · Tyrosine-protein kinase ABL1 (chains A,B) | DFG-out inactive (type II inhibitor-bound) · rule:abl-type2-dfg-out · medium Imatinib (STI) or nilotinib (NIL) bound; type II inhibitors bind the DFG-out conformation. |
| EV-PDB-6NPU-1 RCSB PDB | xray | resolution: 2.33 Å | in vitro · -173.15 °C · ligands 2PE, GOL, KWV, SO4, STI C-abl Kinase domain with the activator(cmpd29), N-(1-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)acetamide · Tyrosine-protein kinase ABL1 (chains A,B) | DFG-out inactive (type II inhibitor-bound) · rule:abl-type2-dfg-out · medium Imatinib (STI) or nilotinib (NIL) bound; type II inhibitors bind the DFG-out conformation. |
| EV-PDB-6NPE-1 RCSB PDB | xray | resolution: 2.15 Å | in vitro · -173.15 °C · ligands 2PE, KWD, SO4, STI C-abl Kinase domain with the activator(cmpd6), 2-cyano-N-(4-(3,4-dichlorophenyl)thiazol-2-yl)acetamide · Tyrosine-protein kinase ABL1 (chains A,B) | DFG-out inactive (type II inhibitor-bound) · rule:abl-type2-dfg-out · medium Imatinib (STI) or nilotinib (NIL) bound; type II inhibitors bind the DFG-out conformation. |
| EV-PDB-6BL8-1 RCSB PDB | xray | resolution: 2.5 Å | in vitro · -173.15 °C · ligands PVB, SO4 Predicting the Conformational Variability of Abl Tyrosine Kinase Using Molecular Dynamics Simulations and Markov State Models · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-5NP2-1 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 6.5 Abl1 SH3 pTyr89/134 · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-5MO4-1 RCSB PDB | xray | resolution: 2.17 Å | in vitro · -173.15 °C · pH 7.5 · ligands AY7, NIL ABL1 kinase (T334I_D382N) in complex with asciminib and nilotinib · Tyrosine-protein kinase ABL1 (chains A) | DFG-out inactive (type II inhibitor-bound) · rule:abl-type2-dfg-out · medium Imatinib (STI) or nilotinib (NIL) bound; type II inhibitors bind the DFG-out conformation. |
| EV-PDB-5HU9-1 RCSB PDB | xray | resolution: 1.529 Å | in vitro · -173.15 °C · pH 8 · ligands 66K, CL, EDO Crystal structure of ABL1 in complex with CHMFL-074 · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-5DC4-1 RCSB PDB | xray | resolution: 1.48 Å | in vitro · -173.15 °C · pH 7.83 · ligands GOL CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A · Tyrosine-protein kinase ABL1 (chains A) | unmapped |
| EV-PDB-4ZOG-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 6.6 · ligands MES, MXE, VX6 VX-680/MK-0457 binds to human ABL1 also in inactive DFG conformations. · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-PDB-4YC8-1 RCSB PDB | xray | resolution: 2.9 Å | in vitro · -173.15 °C · pH 6.5 · ligands 4B7, EDO, MES C-Helix-Out Binding of Dasatinib Analog to c-Abl Kinase · Tyrosine-protein kinase ABL1 (chains A,B) | unmapped |
| EV-BMRB-15488 BMRB | nmr_shifts | chemical_shift | in vitro · 22.35 °C · pH 6.5 Backbone 1H, 15N, 13CO and 13CA resonance assignment of ABL kinase domain in complex with imatinib · BMRB data: 13C chemical shifts, 1H chemical shifts, 15N chemical shifts | unmapped |
| EV-BMRB-30331 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Abl 1b Regulatory Module 'inhibiting state' · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30332 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 7 Abl1b Regulatory Module 'Activating' conformation · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30770 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 7.1 Ablb 1b isoform active state · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30771 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 6.5 Abl isoform 1b inactive1 state · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-30772 BMRB | nmr_shifts | chemical_shift | in vitro · 9.85 °C · pH 7.7 Abl 1b isoform inactive2 state · BMRB data: 13C chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-4252 BMRB | nmr_shifts | chemical_shift | in vitro · 34.85 °C · pH 7.2 Triple Resonance Assignment for Abl SH(32) and One in the Complex with a Consolidated Ligand · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52273 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) apo · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52293 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with asciminib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52296 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-519) apo · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52297 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-519) in complex with imatinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52298 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-517) apo · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52300 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-517) in complex with imatinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52301 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-515) apo · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52302 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-515) in complex with imatinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52305 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform E528K SH3-SH2-KD (aa 83-534) apo · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52306 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform E528K SH3-SH2-KD (aa 83-534) in complex with imatinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52307 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with GNF-5 · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52310 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with PD166326 · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52339 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with imatinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52797 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with nilotinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52798 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with ponatinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52799 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with rebastinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52800 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with bafetinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52802 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with PD180970 · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52803 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with axitinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52804 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with dasatinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52805 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with staurosporine · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52806 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with danusertib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52807 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with tozasertib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52808 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with bosutinib · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52809 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with AMP-PNP · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52810 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) in complex with PD166326 · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52811 BMRB | nmr_shifts | chemical_shift | in vitro · 29.85 °C · pH 8 Abl 1b isoform wild type SH3-SH2-KD (aa 83-534) apo · BMRB data: 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-6570 BMRB | nmr_shifts | chemical_shift | in vitro · 21.85 °C · pH 6.3 NMR Assignments of the F-actin binding domain of human Bcr-Abl/c-Abl · BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts | unmapped |
| EV-DISPROT-DP03166r001 DisProt | xray | disorder_region: 17 residues | in vitro DisProt DP03166: disorder, residues 385-401 · residues 385-401; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-DISPROT-DP03166r002 DisProt | xray | disorder_region: 17 residues | in vitro DisProt DP03166: disorder to order, residues 385-401 · residues 385-401; evidence: x-ray crystallography evidence used in manual assertion | unmapped |
| EV-DISPROT-DP03168r001 DisProt | nmr_shifts | disorder_region: 20 residues | in vitro DisProt DP03168: disorder, residues 1026-1045 · residues 1026-1045 of isoform P00519-2; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion | unmapped |
| EV-DISPROT-DP03168r002 DisProt | xray | disorder_region: 12 residues | in vitro DisProt DP03168: disorder, residues 520-531 · residues 520-531 of isoform P00519-2; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-DISPROT-DP03168r003 DisProt | xray | disorder_region: 112 residues | in vitro DisProt DP03168: disorder, residues 138-249 · residues 138-249 of isoform P00519-2; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion | unmapped |
| EV-AFDB-AF-P00519-F1 AlphaFold DB | af_prediction | plddt: 63.38 pLDDT | in silico AlphaFold DB prediction AF-P00519-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-1130 | unmapped |
| EV-MDDB-A0049 MDDB | md | trajectory: 10 ns | in silico · 26.85 °C MoDEL 2ABL · start 2ABL; Amber Parm99 | unmapped |
Conflicts
No conflicts found among comparable evidence.
127 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.
Downloads
- Protein bundle (JSON)
- Abl-DFG-out-cif (mmCIF, observed)
- Abl-DFG-out-pdb (PDB, observed)
- Abl-active-cif (mmCIF, observed)
- Abl-active-pdb (PDB, observed)
- Abl-Src-like-inactive-cif (mmCIF, observed)
- Abl-Src-like-inactive-pdb (PDB, observed)
- Abl-autoinhibited-cif (mmCIF, observed)
- Abl-autoinhibited-pdb (PDB, observed)
- Curation file (YAML)