Protein diaphanous homolog 1
UniProt O60610 · gene DIAPH1 · Homo sapiens · 1272 residues
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | nmr_structure | nmr_shifts | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|
| No states defined yet. | ||||||
Unmapped evidence: 12 of 12 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 1 | 0 |
| RCSB PDB | 2 | 0 |
| SMASH-BIO | 8 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-8FG1-2 RCSB PDB | nmr_structure | structure | in vitro · 31.85 °C · pH 7.5 Human diaphanous inhibitory domain bound to diaphanous autoregulatory domain · Protein diaphanous homolog 1 (chains B) | unmapped |
| EV-PDB-8FG1-1 RCSB PDB | nmr_structure | structure | in vitro · 31.85 °C · pH 7.5 Human diaphanous inhibitory domain bound to diaphanous autoregulatory domain · Protein diaphanous homolog 1 (chains A) | unmapped |
| EV-BMRB-31064 BMRB | nmr_shifts | chemical_shift | in vitro · 31.85 °C · pH 7.5 Human diaphanous inhibitory domain bound to diaphanous autoregulatory domain · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-AFDB-AF-O60610-F1 AlphaFold DB | af_prediction | plddt: 72.75 pLDDT | in silico AlphaFold DB prediction AF-O60610-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-1272 | unmapped |
| EV-SMASH-SMFS-000509 SMASH-BIO | force_spectroscopy | study_record | in vitro Mechanically-induced remodeling of the cell surface generates actin-rich protrusions resembling tunneling nanotubes · Formin; optical tweezers; experiment class: force_generation_motor | unmapped |
| EV-SMASH-SMFS-001976 SMASH-BIO | force_spectroscopy | study_record | in vitro Intracellular softening and fluidification reveals a mechanical switch of cytoskeletal material contributions during division · Formin; optical tweezers; experiment class: rheology_cell | unmapped |
| EV-SMASH-SMFS-003243-r0 SMASH-BIO | force_spectroscopy | step_size: 2.4 nm | in vitro Processive Nanostepping of Formin mDia1 Loosely Coupled with Actin Polymerization. · Formin; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization | unmapped |
| EV-SMASH-SMFS-003398 SMASH-BIO | force_spectroscopy | study_record | in vitro Adaptive Response of Actin Bundles under Mechanical Stress. · Formin; optical tweezers; experiment class: force_generation_polymerization, rheology_cell | unmapped |
| EV-SMASH-SMFS-003514 SMASH-BIO | force_spectroscopy | study_record | in vitro Force dependence of filopodia adhesion: involvement of myosin II and formins · Formin; optical tweezers; experiment class: force_generation_motor, force_generation_polymerization, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-003794 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 mDia1 senses both force and torque during F-actin filament polymerization. · Formin; magnetic tweezers; experiment class: force_generation_polymerization | unmapped |
| EV-SMASH-SMFS-003796 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 8 αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. · Formin; afm smfs; experiment class: force_generation_motor, receptor_ligand_adhesion | unmapped |
| EV-SMASH-SMFS-004027 SMASH-BIO | force_spectroscopy | study_record | in vitro Regulation of actin catch-slip bonds with a RhoA-formin module. · Formin; afm smfs; experiment class: force_generation_polymerization, receptor_ligand_adhesion | unmapped |
Conflicts
No conflicts found among comparable evidence.
12 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.