ATP-dependent RNA helicase DDX3X
UniProt O00571 · gene DDX3X · Homo sapiens · 662 residues
38evidence items
0mapped to a state
0states
7techniques
6sources
0conflicts
Coverage grid
Mapped evidence per state and technique. Shaded rows rest on a single technique. Badge = best data level in the cell: raw (traces, images, FIDs: can be re-analysed), proc (maps, curves, tables, trajectories) or rep (values in the paper only).
| State | Basis | xray | nmr_dynamics | nmr_shifts | saxs_sans | cd | force_spectroscopy | af_prediction | Total |
|---|---|---|---|---|---|---|---|---|---|
| No states defined yet. | |||||||||
Unmapped evidence: 38 of 38 items. Mappings come from curator assignments and curated rules; see About for how rules work.
Sources
| Source | Evidence | Mapped |
|---|---|---|
| AlphaFold DB | 1 | 0 |
| BMRB | 11 | 0 |
| DisProt | 1 | 0 |
| RCSB PDB | 18 | 0 |
| SASBDB | 6 | 0 |
| SMASH-BIO | 1 | 0 |
Structure
No state models are exported for this protein yet. Observed states export the representative PDB entry; inferred states need fitted models, not yet built.
States and transitions
No states defined.
| State | Basis | Parent | Description |
|---|
No transitions recorded in this version (no rate or free-energy evidence has been curated yet).
Evidence
One row per deposit or experiment. Filter by technique, environment or text. Unmapped evidence is listed too.
| Evidence | Technique | Observable | Conditions | Mapped to state |
|---|---|---|---|---|
| EV-PDB-4O2C-3 RCSB PDB | xray | resolution: 1.802 Å | in vitro · -173.15 °C · pH 6.5 An Nt-acetylated peptide complexed with HLA-B*3901 · Peptide from ATP-dependent RNA helicase DDX3X (chains C) | unmapped |
| EV-PDB-6O5F-1 RCSB PDB | xray | resolution: 2.504 Å | in vitro · -173.15 °C · ligands CL Crystal structure of DEAD-box RNA helicase DDX3X at pre-unwound state · ATP-dependent RNA helicase DDX3X (chains A,B) | unmapped |
| EV-PDB-9E2C-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C · pH 5.5 · ligands GOL Crystal structure of DEAD-box RNA helicase DDX3X R326H mutant · Isoform 2 of ATP-dependent RNA helicase DDX3X (chains A) | unmapped |
| EV-PDB-8SSW-1 RCSB PDB | xray | resolution: 2.4 Å | in vitro · -173.15 °C · pH 6.5 · ligands ADP, EDO, MG Crystal structure of DEAD-box RNA helicase DDX3X in complex with ADP at pre-unwound state · ATP-dependent RNA helicase DDX3X (chains A,B) | unmapped |
| EV-PDB-7YMF-2 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C Crystal Structure of DDX3X449_450ET>DP · ATP-dependent RNA helicase DDX3X (chains B) | unmapped |
| EV-PDB-7YMF-1 RCSB PDB | xray | resolution: 2.3 Å | in vitro · -173.15 °C Crystal Structure of DDX3X449_450ET>DP · ATP-dependent RNA helicase DDX3X (chains A) | unmapped |
| EV-PDB-7LIU-1 RCSB PDB | xray | resolution: 3.001 Å | in vitro · -73.15 °C · pH 7.5 · ligands 08T, MG DDX3X bound to ATP analog and remodeled RNA:DNA hybrid · ATP-dependent RNA helicase DDX3X (chains A,B) | unmapped |
| EV-PDB-6CZ5-1 RCSB PDB | xray | resolution: 3 Å | in vitro · -173.15 °C · pH 5 · ligands FPJ Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C · ATP-dependent RNA helicase DDX3X (chains A) | unmapped |
| EV-PDB-5E7M-1 RCSB PDB | xray | resolution: 2.304 Å | in vitro · -173.15 °C · pH 5 · ligands ANP Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMPPNP · ATP-dependent RNA helicase DDX3X (chains A) | unmapped |
| EV-PDB-5E7J-1 RCSB PDB | xray | resolution: 2.23 Å | in vitro · -173.15 °C · pH 5 · ligands AMP Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMP · ATP-dependent RNA helicase DDX3X (chains A) | unmapped |
| EV-PDB-5E7I-1 RCSB PDB | xray | resolution: 2.223 Å | in vitro · -173.15 °C · pH 5 Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 · ATP-dependent RNA helicase DDX3X (chains A,B,C) | unmapped |
| EV-PDB-4PXA-1 RCSB PDB | xray | resolution: 3.2 Å | in vitro · -173.15 °C · ligands ADP, PO4 DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V · ATP-dependent RNA helicase DDX3X (chains A) | unmapped |
| EV-PDB-4PX9-1 RCSB PDB | xray | resolution: 2.31 Å | in vitro · -173.15 °C · pH 7.6 · ligands ADP DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop · ATP-dependent RNA helicase DDX3X (chains A,B,C) | unmapped |
| EV-PDB-4O2F-3 RCSB PDB | xray | resolution: 1.901 Å | in vitro · -173.15 °C · pH 8 A peptide complexed with HLA-B*3901 · Peptide from ATP-dependent RNA helicase DDX3X (chains C,F) | unmapped |
| EV-PDB-4O2E-3 RCSB PDB | xray | resolution: 1.981 Å | in vitro · -173.15 °C · pH 6.5 A peptide complexed with HLA-B*3901 · Peptide from ATP-dependent RNA helicase DDX3X (chains C,F) | unmapped |
| EV-PDB-3JRV-2 RCSB PDB | xray | resolution: 1.6 Å | in vitro · -173.15 °C · pH 5.25 Structure of poxvirus K7 protein in complex with RNA helicase DDX3 · ATP-dependent RNA helicase DDX3X (chains C,D,E) | unmapped |
| EV-PDB-2JGN-1 RCSB PDB | xray | resolution: 1.91 Å | in vitro · -163.15 °C DDX3 helicase domain · ATP-DEPENDENT RNA HELICASE DDX3X (chains A,B,C) | unmapped |
| EV-PDB-2I4I-1 RCSB PDB | xray | resolution: 2.2 Å | in vitro · -173.15 °C · pH 7.5 · ligands AMP Crystal Structure of human DEAD-box RNA helicase DDX3X · ATP-dependent RNA helicase DDX3X (chains A) | unmapped |
| EV-BMRB-52142 BMRB | nmr_shifts | chemical_shift | in vitro · 24.85 °C · pH 6.5 1H, 15N and 13C chemical shift assignments for the D2 domain of the human DEAD-box RNA helicase DDX3X · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52738 BMRB | nmr_shifts | chemical_shift | in vitro · 10 °C · pH 6 1H, 15N, and 13C chemical shift assignments for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52739 BMRB | nmr_shifts | chemical_shift | in vitro · 10 °C · pH 7 1H, 15N, and 13C chemical shift assignments for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X RtoK variant · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52740 BMRB | nmr_shifts | chemical_shift | in vitro · 10 °C · pH 6 1H, 15N, and 13C chemical shift assignments for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X FYtoA variant · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52741 BMRB | nmr_shifts | chemical_shift | in vitro · 10 °C · pH 7 1H, 15N, and 13C chemical shift assignments for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X RKtoA-1 variant · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52742 BMRB | nmr_shifts | chemical_shift | in vitro · 10 °C · pH 7 1H, 15N, and 13C chemical shift assignments for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X RKtoA-2 variant · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-52743 BMRB | nmr_shifts | chemical_shift | in vitro · 10 °C · pH 7 1H, 15N, and 13C chemical shift assignments for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X RKtoA-3 variant · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-BMRB-53296 BMRB | nmr_dynamics | relaxation_rate | in vitro · 10 °C · pH 6 15N-Relaxation data for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X · BMRB data: T1 relaxation values, T2 relaxation values, heteronuclear NOE values | unmapped |
| EV-BMRB-53297 BMRB | nmr_dynamics | relaxation_rate | in vitro · 10 °C · pH 6 15N-Relaxation data for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X RtoK variant · BMRB data: T1 relaxation values, T2 relaxation values, heteronuclear NOE values | unmapped |
| EV-BMRB-53298 BMRB | nmr_dynamics | relaxation_rate | in vitro · 10 °C · pH 6 15N-Relaxation data for the N-terminal region (residues 1-132) of the human DEAD-box RNA helicase DDX3X FYtoA variant · BMRB data: T1 relaxation values, T2 relaxation values, heteronuclear NOE values | unmapped |
| EV-BMRB-53627 BMRB | nmr_shifts | chemical_shift | in vitro · 10 °C · pH 6 1H, 15N, and 13C chemical shift assignments for the N-terminal region (residues 1-168) of the human DEAD-box RNA helicase DDX3X · BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts | unmapped |
| EV-SASBDB-SASDR65 SASBDB | saxs_sans | radius_of_gyration: 3.836 nm ± 0.349 | in vitro · 16 °C · pH 8 Solution structures of DEAD-box helicase DDX3X reveal the N-terminal extension binds RNA to modulate catalysis and influence conformation · ATP-dependent RNA helicase DDX3X (truncation; amino acids 1-580) | unmapped |
| EV-SASBDB-SASDR75 SASBDB | saxs_sans | radius_of_gyration: 3.587 nm ± 0.521 | in vitro · 16 °C · pH 8 Solution structures of DEAD-box helicase DDX3X reveal the N-terminal extension binds RNA to modulate catalysis and influence conformation · ATP-dependent RNA helicase DDX3X (truncation; amino acids 50-580) | unmapped |
| EV-SASBDB-SASDR85 SASBDB | saxs_sans | radius_of_gyration: 3.366 nm ± 0.24 | in vitro · 16 °C · pH 8 Solution structures of DEAD-box helicase DDX3X reveal the N-terminal extension binds RNA to modulate catalysis and influence conformation · ATP-dependent RNA helicase DDX3X (truncation; amino acids 100-580) | unmapped |
| EV-SASBDB-SASDR95 SASBDB | saxs_sans | radius_of_gyration: 3.124 nm ± 0.163 | in vitro · 16 °C · pH 8 Solution structures of DEAD-box helicase DDX3X reveal the N-terminal extension binds RNA to modulate catalysis and influence conformation · ATP-dependent RNA helicase DDX3X (truncation; amino acids 135-580) | unmapped |
| EV-SASBDB-SASDRB5 SASBDB | saxs_sans | radius_of_gyration: 3.61 nm ± 0.314 | in vitro · 16 °C · pH 8 · ligands partner: 15 nucleotide RNA duplex (ATP-dependent RNA helicase DDX3X binding target) Solution structures of DEAD-box helicase DDX3X reveal the N-terminal extension binds RNA to modulate catalysis and influence conformation · ATP-dependent RNA helicase DDX3X (truncation; amino acids 1-580) with 15 nucleotide RNA duplex (ATP-dependent RNA helicase DDX3X binding target) | unmapped |
| EV-SASBDB-SASDRC5 SASBDB | saxs_sans | radius_of_gyration: 2.878 nm ± 0.378 | in vitro · 16 °C · pH 8 · ligands partner: 15 nucleotide RNA duplex (ATP-dependent RNA helicase DDX3X binding target) Solution structures of DEAD-box helicase DDX3X reveal the N-terminal extension binds RNA to modulate catalysis and influence conformation · ATP-dependent RNA helicase DDX3X (truncation; amino acids 135-580) with 15 nucleotide RNA duplex (ATP-dependent RNA helicase DDX3X binding target) | unmapped |
| EV-DISPROT-DP02192r001 DisProt | cd | disorder_region: 167 residues | in vitro DisProt DP02192: disorder, residues 1-167 · residues 1-167; evidence: far-UV circular dichroism evidence used in manual assertion | unmapped |
| EV-AFDB-AF-O00571-F1 AlphaFold DB | af_prediction | plddt: 72.19 pLDDT | in silico AlphaFold DB prediction AF-O00571-F1 · AlphaFold Monomer v2.0 pipeline, residues 1-662 | unmapped |
| EV-SMASH-SMFS-002797 SMASH-BIO | force_spectroscopy | study_record | in vitro · pH 7.5 Mechanistic characterization of the DEAD-box RNA helicase Ded1 from yeast as revealed by a novel technique using single-molecule magnetic tweezers. · DDX3; magnetic tweezers; experiment class: force_generation_motor, nucleic_acid_protein_interaction, translation_transcription_replication | unmapped |
Conflicts
No conflicts found among comparable evidence.
32 evidence items could not be compared: they lack a comparable observable type, a value, or an uncertainty. Absence of a conflict here is not agreement.