{
  "conflicts": [],
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        "xray": 2
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    },
    "data_levels": {
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        "cryoem": "processed"
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      "talin-rod-unfolded": {
        "force_spectroscopy": "reported",
        "xray": "processed"
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    },
    "single_method_states": [
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      "talin-autoinhibited",
      "talin-rod-unfolded"
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        "ligands": [],
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        "temperature_c": -173.15
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        {
          "confidence": "low",
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    {
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      },
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          "confidence": "high",
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    {
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      },
      "data_format": "NMR-STAR",
      "data_level": "processed",
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      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "nmr_shifts",
      "title": "Chemical shift assignments of the VBS1 domain of talin"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
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        "ions": [],
        "ligands": [],
        "notes": "From the first sample condition list of the entry.",
        "ph": 6.5,
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        "temperature_c": 24.85
      },
      "construct": {
        "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts",
        "labels": []
      },
      "data_format": "NMR-STAR",
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      "reader": null,
      "source_kind": "deposit",
      "technique": "nmr_shifts",
      "title": "Solution Structure of the A domain of talin"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "From the first sample condition list of the entry.",
        "ph": 6.8,
        "salt_mM": null,
        "temperature_c": -0.15
      },
      "construct": {
        "description": "BMRB data: 1H chemical shifts, 15N chemical shifts",
        "labels": []
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      "data_format": "NMR-STAR",
      "data_level": "processed",
      "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=25343",
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        "applied_force_pn": null,
        "buffer": null,
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        "ligands": [],
        "notes": "From the first sample condition list of the entry.",
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        "temperature_c": 29.85
      },
      "construct": {
        "description": "BMRB data: 15N chemical shifts, 1H chemical shifts, 13C chemical shifts",
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      "technique": "nmr_shifts",
      "title": "15N, 13C, 1H NMR assignment of a 14kDa construct of the focal adhesion protein Talin"
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        "temperature_c": 24.85
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        "environment": "in_vitro",
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        "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 13.25 nm.",
        "ph": 7.2,
        "salt_mM": null,
        "temperature_c": 10.0
      },
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        "description": "Talin-1 (Δ139-168), human",
        "labels": []
      },
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        "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 11.49 nm.",
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        "temperature_c": 10.0
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        "labels": []
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      "reader": null,
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      "technique": "saxs_sans",
      "title": "The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering."
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      "reader": null,
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    }
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    "domains": [
      {
        "end": 403,
        "name": "FERM",
        "start": 86
      },
      {
        "end": 2533,
        "name": "I/LWEQ",
        "start": 2293
      }
    ],
    "gene": "TLN1",
    "identifiers": {
      "genbank": null,
      "isoform": null,
      "nakb": null,
      "pdb": [],
      "rfam": null,
      "rnacentral": null,
      "uniprot": "Q9Y490"
    },
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        "name": "Phosphothreonine",
        "position": 167,
        "source": "UniProtKB"
      },
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        "name": "Phosphoserine",
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        "source": "UniProtKB"
      },
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        "name": "Phosphoserine",
        "position": 425,
        "source": "UniProtKB"
      },
      {
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        "name": "Phosphoserine",
        "position": 446,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 620,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 729,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1021,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphotyrosine",
        "position": 1116,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphothreonine",
        "position": 1142,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1201,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1225,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphothreonine",
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        "source": "UniProtKB"
      },
      {
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        "name": "Phosphoserine",
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        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "N6-acetyllysine",
        "position": 1544,
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      },
      {
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        "name": "Phosphoserine",
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        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
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        "position": 1855,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1878,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "N6-acetyllysine",
        "position": 2031,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 2040,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "N6-acetyllysine",
        "position": 2115,
        "source": "UniProtKB"
      }
    ],
    "molecule_id": "Q9Y490",
    "molecule_type": "protein",
    "name": "Talin-1",
    "organism": {
      "name": "Homo sapiens",
      "taxon_id": 9606
    },
    "provenance": {
      "deposit_id": "Q9Y490",
      "doi": null,
      "licence": "CC BY 4.0 (UniProt)",
      "retrieved": "2026-10-19",
      "source": "UniProtKB",
      "url": "https://www.uniprot.org/uniprotkb/Q9Y490/entry"
    },
    "sequence": "MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH",
    "sequence_length": 2541
  },
  "molecule_id": "Q9Y490",
  "states": [
    {
      "assumptions": [],
      "basis": "observed",
      "description": "Full-length talin-1 folded into a compact autoinhibited arrangement, as in 6R9T (cryo-EM, 6.2 Å).",
      "family_label": null,
      "molecule_id": "Q9Y490",
      "name": "autoinhibited, compact",
      "parent_state": null,
      "population": null,
      "provenance": {
        "deposit_id": null,
        "doi": null,
        "licence": "Project licence (pending decision)",
        "retrieved": "2026-10-19",
        "source": "Conformome curation (Q9Y490.yaml)",
        "url": "https://github.com/matth55/conformome/blob/HEAD/curation/Q9Y490.yaml"
      },
      "representative_model": "talin-autoinhibited-cif",
      "secondary_structure": null,
      "state_id": "talin-autoinhibited",
      "status": "draft"
    },
    {
      "assumptions": [
        "Defined from force spectroscopy of rod domains; no structure of the force-unfolded rod exists.",
        "Vinculin-bound VBS peptide structures show the exposed helix only, not the rod.",
        "Bundles are treated together; which bundles unfold at which force is not resolved here. No model is exported."
      ],
      "basis": "inferred",
      "description": "Rod helical bundles unfolded by mechanical load, exposing vinculin-binding helices.",
      "family_label": null,
      "molecule_id": "Q9Y490",
      "name": "rod unfolded under force (vinculin-binding sites exposed)",
      "parent_state": null,
      "population": null,
      "provenance": {
        "deposit_id": null,
        "doi": null,
        "licence": "Project licence (pending decision)",
        "retrieved": "2026-10-19",
        "source": "Conformome curation (Q9Y490.yaml)",
        "url": "https://github.com/matth55/conformome/blob/HEAD/curation/Q9Y490.yaml"
      },
      "representative_model": null,
      "secondary_structure": null,
      "state_id": "talin-rod-unfolded",
      "status": "draft"
    }
  ],
  "transitions": []
}