{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "saxs_sans", "force_spectroscopy", "af_prediction", "md" ], "unmapped_evidence": 497 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "XX5", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "angiotensin I converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1R4L", "evidence_id": "EV-PDB-1R4L-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "1R4L", "doi": "10.1074/jbc.M311191200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1R4L" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/22HG", "evidence_id": "EV-PDB-22HG-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.61 }, "provenance": { "deposit_id": "22HG", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/22HG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 BA.3.2.2(RE.2.2) RBD in complex with human ACE2 and monoclonal antibody S2H97" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme-Related Carboxypeptidase (Ace2) (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2AJF", "evidence_id": "EV-PDB-2AJF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "2AJF", "doi": "10.1126/science.1116480", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2AJF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS coronavirus spike receptor-binding domain complexed with its receptor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "NDG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D0G", "evidence_id": "EV-PDB-3D0G-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "3D0G", "doi": "10.1128/JVI.00442-08", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D0G" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus human strain complexed with human-civet chimeric receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "NDG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D0H", "evidence_id": "EV-PDB-3D0H-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "3D0H", "doi": "10.1128/JVI.00442-08", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D0H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor-binding domain from the 2002-2003 SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "NDG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D0I", "evidence_id": "EV-PDB-3D0I-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "3D0I", "doi": "10.1128/JVI.00442-08", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D0I" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor-binding domain from the 2005-2006 SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3KBH", "evidence_id": "EV-PDB-3KBH-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.31 }, "provenance": { "deposit_id": "3KBH", "doi": "10.1073/pnas.0908837106", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3KBH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SCI", "evidence_id": "EV-PDB-3SCI-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "3SCI", "doi": "10.1074/jbc.M111.325803", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SCI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus human strain complexed with human receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SCJ", "evidence_id": "EV-PDB-3SCJ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "3SCJ", "doi": "10.1074/jbc.M111.325803", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SCJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 chimera (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SCK", "evidence_id": "EV-PDB-3SCK-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "3SCK", "doi": "10.1074/jbc.M111.325803", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SCK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human-civet chimeric receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 chimera (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SCL", "evidence_id": "EV-PDB-3SCL-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "3SCL", "doi": "10.1074/jbc.M111.325803", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SCL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor-binding domain from SARS coronavirus epidemic strain complexed with human-civet chimeric receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6ACG", "evidence_id": "EV-PDB-6ACG-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 5.4 }, "provenance": { "deposit_id": "6ACG", "doi": "10.1371/journal.ppat.1007236", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6ACG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6ACJ", "evidence_id": "EV-PDB-6ACJ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.2 }, "provenance": { "deposit_id": "6ACJ", "doi": "10.1371/journal.ppat.1007236", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6ACJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6CS2", "evidence_id": "EV-PDB-6CS2-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.4 }, "provenance": { "deposit_id": "6CS2", "doi": "10.1038/s41598-018-34171-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6CS2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS Spike Glycoprotein - human ACE2 complex, Stabilized variant, all ACE2-bound particles" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6LZG", "evidence_id": "EV-PDB-6LZG-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "6LZG", "doi": "10.1016/j.cell.2020.03.045", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6LZG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of novel coronavirus spike receptor-binding domain complexed with its receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6M0J", "evidence_id": "EV-PDB-6M0J-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.45 }, "provenance": { "deposit_id": "6M0J", "doi": "10.1038/s41586-020-2180-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6M0J" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LEU", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6M17", "evidence_id": "EV-PDB-6M17-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "6M17", "doi": "10.1126/science.abb2762", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6M17" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The 2019-nCoV RBD/ACE2-B0AT1 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3PH", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6M18", "evidence_id": "EV-PDB-6M18-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "6M18", "doi": "10.1126/science.abb2762", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6M18" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-B0AT1 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7A91", "evidence_id": "EV-PDB-7A91-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7A91", "doi": "10.1038/s41586-020-2772-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7A91" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7A92", "evidence_id": "EV-PDB-7A92-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.2 }, "provenance": { "deposit_id": "7A92", "doi": "10.1038/s41586-020-2772-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7A92" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Unmasked Refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7A94", "evidence_id": "EV-PDB-7A94-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7A94", "doi": "10.1038/s41586-020-2772-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7A94" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7A95", "evidence_id": "EV-PDB-7A95-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.3 }, "provenance": { "deposit_id": "7A95", "doi": "10.1038/s41586-020-2772-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7A95" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound and 1 RBD Erect in Clockwise Direction" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7A96", "evidence_id": "EV-PDB-7A96-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.8 }, "provenance": { "deposit_id": "7A96", "doi": "10.1038/s41586-020-2772-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7A96" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound and 1 RBD Erect in Anticlockwise Direction" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7A97", "evidence_id": "EV-PDB-7A97-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.4 }, "provenance": { "deposit_id": "7A97", "doi": "10.1038/s41586-020-2772-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7A97" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with 2 ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7A98", "evidence_id": "EV-PDB-7A98-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 5.4 }, "provenance": { "deposit_id": "7A98", "doi": "10.1038/s41586-020-2772-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7A98" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with 3 ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7BH9", "evidence_id": "EV-PDB-7BH9-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "7BH9", "doi": "10.1038/s41564-021-00954-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7BH9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 RBD-62 in complex with ACE2 peptidase domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7CT5", "evidence_id": "EV-PDB-7CT5-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "7CT5", "doi": "10.1038/s41422-020-00438-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7CT5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S protein of SARS-CoV-2 in complex bound with T-ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DDO", "evidence_id": "EV-PDB-7DDO-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7DDO", "doi": "10.15252/embj.2021107786", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DDO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human ACE2 and GD/1/2019 RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DDP", "evidence_id": "EV-PDB-7DDP-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7DDP", "doi": "10.15252/embj.2021107786", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DDP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human ACE2 and GX/P2V/2017 RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DF4", "evidence_id": "EV-PDB-7DF4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "7DF4", "doi": "10.1126/sciadv.abe5575", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DF4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 S-ACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "SO4", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DMU", "evidence_id": "EV-PDB-7DMU-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7DMU", "doi": "10.1038/s41467-021-24013-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DMU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 spike receptor-binding domain complexed with high affinity ACE2 mutant 3N39" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DQA", "evidence_id": "EV-PDB-7DQA-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7DQA", "doi": "10.52601/bpr.2021.210007", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DQA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV2 RBD-ACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DRV", "evidence_id": "EV-PDB-7DRV-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.09 }, "provenance": { "deposit_id": "7DRV", "doi": "10.1016/j.cell.2021.05.031", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DRV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of SARS-CoV-2-closely-related bat coronavirus RaTG13 to hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LEU", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DWX", "evidence_id": "EV-PDB-7DWX-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 8.3 }, "provenance": { "deposit_id": "7DWX", "doi": "10.1038/s41422-021-00490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DWX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Conformation 1 of S-ACE2-B0AT1 ternary complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DX4", "evidence_id": "EV-PDB-7DX4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7DX4", "doi": "10.1093/nsr/nwab053", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DX4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The structure of FC08 Fab-hA.CE2-RBD complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DX5", "evidence_id": "EV-PDB-7DX5-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7DX5", "doi": "10.1038/s41422-021-00490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DX5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (1 up RBD and 1 PD bound)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DX6", "evidence_id": "EV-PDB-7DX6-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7DX6", "doi": "10.1038/s41422-021-00490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DX6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (2 up RBD and 1 PD bound)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DX7", "evidence_id": "EV-PDB-7DX7-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7DX7", "doi": "10.1038/s41422-021-00490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DX7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and 1 PD bound)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DX8", "evidence_id": "EV-PDB-7DX8-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "7DX8", "doi": "10.1038/s41422-021-00490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DX8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (2 up RBD and 2 PD bound)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DX9", "evidence_id": "EV-PDB-7DX9-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7DX9", "doi": "10.1038/s41422-021-00490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DX9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (3 up RBD and 2 PD bound)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7E7E", "evidence_id": "EV-PDB-7E7E-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "7E7E", "doi": "10.1038/s41467-021-25331-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7E7E" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The co-crystal structure of ACE2 with Fab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (ACE2) ectodomain (chains I,J,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EDJ", "evidence_id": "EV-PDB-7EDJ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7EDJ", "doi": "10.1038/s41594-021-00652-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EDJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-UK variant (B.1.1.7) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EFP", "evidence_id": "EV-PDB-7EFP-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.698 }, "provenance": { "deposit_id": "7EFP", "doi": "10.1038/s41392-021-00756-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EFP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (S19W,N330Y)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EFR", "evidence_id": "EV-PDB-7EFR-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.494 }, "provenance": { "deposit_id": "7EFR", "doi": "10.1038/s41392-021-00756-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EFR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EKC", "evidence_id": "EV-PDB-7EKC-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7EKC", "doi": "10.1038/s41467-021-26401-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EKC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 Gamma variant spike receptor-binding domain complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6VW1", "evidence_id": "EV-PDB-6VW1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.68 }, "provenance": { "deposit_id": "6VW1", "doi": "10.1038/s41586-020-2179-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6VW1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 chimeric receptor-binding domain complexed with its receptor human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6M1D", "evidence_id": "EV-PDB-6M1D-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.5 }, "provenance": { "deposit_id": "6M1D", "doi": "10.1126/science.abb2762", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6M1D" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-B0AT1 complex, open conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6ACK", "evidence_id": "EV-PDB-6ACK-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.5 }, "provenance": { "deposit_id": "6ACK", "doi": "10.1371/journal.ppat.1007236", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6ACK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/28KD", "evidence_id": "EV-PDB-28KD-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.02 }, "provenance": { "deposit_id": "28KD", "doi": "10.1021/acs.jmedchem.5c02876", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/28KD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2 extracellular domain in complex with the macrocyclic peptide GR3.1.2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -133.15 }, "construct": { "description": "angiotensin I converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1R42", "evidence_id": "EV-PDB-1R42-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1R42", "doi": "10.1074/jbc.M311191200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1R42" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EKE", "evidence_id": "EV-PDB-7EKE-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "7EKE", "doi": "10.1038/s41467-021-26401-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EKE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 spike receptor-binding domain F486L mutation complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EKF", "evidence_id": "EV-PDB-7EKF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "7EKF", "doi": "10.1038/s41467-021-26401-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EKF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 Alpha variant spike receptor-binding domain complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EKG", "evidence_id": "EV-PDB-7EKG-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.63 }, "provenance": { "deposit_id": "7EKG", "doi": "10.1038/s41467-021-26401-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EKG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 Beta variant spike receptor-binding domain complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7FDH", "evidence_id": "EV-PDB-7FDH-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.72 }, "provenance": { "deposit_id": "7FDH", "doi": "10.1038/s41467-021-25903-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7FDH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-COV-2 Spike RBDMACSp25 binding to hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7FDI", "evidence_id": "EV-PDB-7FDI-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.12 }, "provenance": { "deposit_id": "7FDI", "doi": "10.1038/s41467-021-25903-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7FDI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-COV-2 Spike RBDMACSp36 binding to hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7FEM", "evidence_id": "EV-PDB-7FEM-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.1 }, "provenance": { "deposit_id": "7FEM", "doi": "10.1038/s41421-021-00349-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7FEM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 B.1.1.7 S-ACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "ARG-LYS-LYS-LYS-ASN-LYS-ALA (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7JVO", "evidence_id": "EV-PDB-7JVO-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "7JVO", "doi": "10.1038/s41421-021-00279-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7JVO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Importin alpha bound to the C-terminus of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KJ2", "evidence_id": "EV-PDB-7KJ2-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7KJ2", "doi": "10.1038/s41594-020-00549-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KJ2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KJ3", "evidence_id": "EV-PDB-7KJ3-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "7KJ3", "doi": "10.1038/s41594-020-00549-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KJ3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KJ4", "evidence_id": "EV-PDB-7KJ4-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7KJ4", "doi": "10.1038/s41594-020-00549-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KJ4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike Glycoprotein with three ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KMS", "evidence_id": "EV-PDB-7KMS-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.64 }, "provenance": { "deposit_id": "7KMS", "doi": "10.1016/j.chom.2020.11.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KMS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KMZ", "evidence_id": "EV-PDB-7KMZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.62 }, "provenance": { "deposit_id": "7KMZ", "doi": "10.1016/j.chom.2020.11.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KMZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KNB", "evidence_id": "EV-PDB-7KNB-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.93 }, "provenance": { "deposit_id": "7KNB", "doi": "10.1016/j.chom.2020.11.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KNB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 7.4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KNE", "evidence_id": "EV-PDB-7KNE-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.85 }, "provenance": { "deposit_id": "7KNE", "doi": "10.1016/j.chom.2020.11.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KNE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KNH", "evidence_id": "EV-PDB-7KNH-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.74 }, "provenance": { "deposit_id": "7KNH", "doi": "10.1016/j.chom.2020.11.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KNH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM Structure of Double ACE2-Bound SARS-CoV-2 Trimer Spike at pH 5.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KNI", "evidence_id": "EV-PDB-7KNI-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.91 }, "provenance": { "deposit_id": "7KNI", "doi": "10.1016/j.chom.2020.11.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KNI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 5.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NA", "NAG", "PG4", "PG5", "PGE", "SO4", "ZN", "branched: alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7L0N", "evidence_id": "EV-PDB-7L0N-5", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.78 }, "provenance": { "deposit_id": "7L0N", "doi": "10.1016/j.cell.2021.01.037", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7L0N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7LO4", "evidence_id": "EV-PDB-7LO4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.465 }, "provenance": { "deposit_id": "7LO4", "doi": "10.1101/2021.03.16.434488", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7LO4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SARS-CoV-2 spike receptor-binding domain with a G485R mutation in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7MJN", "evidence_id": "EV-PDB-7MJN-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "7MJN", "doi": "10.1371/journal.pbio.3001237", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7MJN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7NXC", "evidence_id": "EV-PDB-7NXC-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "7NXC", "doi": "10.1016/j.cell.2021.03.055", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7NXC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P19", "evidence_id": "EV-PDB-7P19-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.24 }, "provenance": { "deposit_id": "7P19", "doi": "10.1107/S2059798322007677", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P19" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SARS-CoV-2 RBD Q498Y complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 2.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P55", "evidence_id": "EV-PDB-7P55-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "7P55", "doi": "10.1016/j.heliyon.2022.e11568", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P55" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR structure of human ACE2 21-42 fragment in HFIP/water 50/50 v/v" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P8I", "evidence_id": "EV-PDB-7P8I-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.5 }, "provenance": { "deposit_id": "7P8I", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P8I" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Receptor-binding domain (RBD) of the spike protein of the bat coronavirus RaTG13 virus in complex with the extracellular domain of human angiotensin-converting enzyme 2 (ACE2) - Crystal form 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P8J", "evidence_id": "EV-PDB-7P8J-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 6.585 }, "provenance": { "deposit_id": "7P8J", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P8J" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Receptor-binding domain (RBD) of the spike protein of the bat coronavirus RaTG13 virus in complex with the extracellular domain of human angiotensin-converting enzyme 2 (ACE2) - Crystal form 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7R10", "evidence_id": "EV-PDB-7R10-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "7R10", "doi": "10.1038/s41467-022-28768-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7R10" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dissociated S1 domain of Alpha Variant SARS-CoV-2 Spike bound to ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7R11", "evidence_id": "EV-PDB-7R11-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "7R11", "doi": "10.1038/s41467-022-28768-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7R11" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dissociated S1 domain of Beta Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7R12", "evidence_id": "EV-PDB-7R12-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7R12", "doi": "10.1038/s41467-022-28768-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7R12" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dissociated S1 domain of Mink Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7R1A", "evidence_id": "EV-PDB-7R1A-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7R1A", "doi": "10.1038/s41467-022-28768-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7R1A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Furin Cleaved Alpha Variant SARS-CoV-2 Spike in complex with 3 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RPV", "evidence_id": "EV-PDB-7RPV-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.54 }, "provenance": { "deposit_id": "7RPV", "doi": "10.1101/2021.11.24.469776", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RPV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SN0", "evidence_id": "EV-PDB-7SN0-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.08 }, "provenance": { "deposit_id": "7SN0", "doi": "10.1126/science.abl6251", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SN0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SXX", "evidence_id": "EV-PDB-7SXX-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.66 }, "provenance": { "deposit_id": "7SXX", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SXX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SXY", "evidence_id": "EV-PDB-7SXY-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.79 }, "provenance": { "deposit_id": "7SXY", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SXY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SXZ", "evidence_id": "EV-PDB-7SXZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.61 }, "provenance": { "deposit_id": "7SXZ", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SXZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,L452R mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY0", "evidence_id": "EV-PDB-7SY0-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7SY0", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,L452R mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY1", "evidence_id": "EV-PDB-7SY1-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "7SY1", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY2", "evidence_id": "EV-PDB-7SY2-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.11 }, "provenance": { "deposit_id": "7SY2", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY3", "evidence_id": "EV-PDB-7SY3-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "7SY3", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY4", "evidence_id": "EV-PDB-7SY4-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.35 }, "provenance": { "deposit_id": "7SY4", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY5", "evidence_id": "EV-PDB-7SY5-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.59 }, "provenance": { "deposit_id": "7SY5", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417N mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY6", "evidence_id": "EV-PDB-7SY6-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.81 }, "provenance": { "deposit_id": "7SY6", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417N mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY7", "evidence_id": "EV-PDB-7SY7-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.81 }, "provenance": { "deposit_id": "7SY7", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417T mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SY8", "evidence_id": "EV-PDB-7SY8-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "7SY8", "doi": "10.1016/j.celrep.2021.110156", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SY8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417T mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7T9K", "evidence_id": "EV-PDB-7T9K-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.45 }, "provenance": { "deposit_id": "7T9K", "doi": "10.1126/science.abn7760", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7T9K" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7R0Z", "evidence_id": "EV-PDB-7R0Z-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "7R0Z", "doi": "10.1038/s41467-022-28768-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7R0Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dissociated S1 domain of Alpha Variant SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "NAG", "PEG", "SO4", "TRS", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7PKI", "evidence_id": "EV-PDB-7PKI-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.94234133444 }, "provenance": { "deposit_id": "7PKI", "doi": "10.1038/s41586-022-04532-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7PKI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human ACE2 bound to the spike receptor-binding domain from a cave bat sarbecovirus closely related to SARS-CoV-2." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7MJM", "evidence_id": "EV-PDB-7MJM-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "7MJM", "doi": "10.1371/journal.pbio.3001237", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7MJM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7L7F", "evidence_id": "EV-PDB-7L7F-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.24 }, "provenance": { "deposit_id": "7L7F", "doi": "10.1038/s41586-021-03275-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7L7F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KMB", "evidence_id": "EV-PDB-7KMB-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.39 }, "provenance": { "deposit_id": "7KMB", "doi": "10.1016/j.chom.2020.11.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KMB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-RBD Focused Refinement Using Symmetry Expansion of Applied C3 for Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 7.4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7FDG", "evidence_id": "EV-PDB-7FDG-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.69 }, "provenance": { "deposit_id": "7FDG", "doi": "10.1038/s41467-021-25903-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7FDG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-COV-2 Spike RBDMACSp6 binding to hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EKH", "evidence_id": "EV-PDB-7EKH-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "7EKH", "doi": "10.1038/s41467-021-26401-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EKH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 spike receptor-binding domain Y453F mutation complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7T9L", "evidence_id": "EV-PDB-7T9L-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.66 }, "provenance": { "deposit_id": "7T9L", "doi": "10.1126/science.abn7760", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7T9L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TEW", "evidence_id": "EV-PDB-7TEW-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.52 }, "provenance": { "deposit_id": "7TEW", "doi": "10.1038/s41467-022-28324-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TEW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Delta (B.1.617.2) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TEX", "evidence_id": "EV-PDB-7TEX-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.27 }, "provenance": { "deposit_id": "7TEX", "doi": "10.1038/s41467-022-28324-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TEX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Delta (B.1.617.2) spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TEZ", "evidence_id": "EV-PDB-7TEZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.27 }, "provenance": { "deposit_id": "7TEZ", "doi": "10.1038/s41467-022-28324-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TEZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Kappa (B.1.617.1) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TF0", "evidence_id": "EV-PDB-7TF0-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.02 }, "provenance": { "deposit_id": "7TF0", "doi": "10.1038/s41467-022-28324-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TF0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Kappa (B.1.617.1) spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TN0", "evidence_id": "EV-PDB-7TN0-3", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "7TN0", "doi": "10.1126/science.abn8652", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TN0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SARS-CoV-2 Omicron RBD in complex with human ACE2 and S304 Fab and S309 Fab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "MG", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7U0N", "evidence_id": "EV-PDB-7U0N-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.61 }, "provenance": { "deposit_id": "7U0N", "doi": "10.1128/jvi.00249-22", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7U0N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric omicron RBD (strain BA.1) complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NA", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7UFK", "evidence_id": "EV-PDB-7UFK-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.38 }, "provenance": { "deposit_id": "7UFK", "doi": "10.1073/pnas.2206509119", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7UFK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric omicron RBD (strain BA.2) complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V61", "evidence_id": "EV-PDB-7V61-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7V61", "doi": "10.1038/s41392-021-00740-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V61" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V80", "evidence_id": "EV-PDB-7V80-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7V80", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V80" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local refinement of SARS-CoV-2 S-Beta variant (B.1.351) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V82", "evidence_id": "EV-PDB-7V82-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7V82", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V82" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V83", "evidence_id": "EV-PDB-7V83-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7V83", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V83" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V84", "evidence_id": "EV-PDB-7V84-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7V84", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V84" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local refinement of SARS-CoV-2 S-Gamma variant (P.1) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V86", "evidence_id": "EV-PDB-7V86-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7V86", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V86" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Angiotensin-converting enzyme 2 (ACE2) ectodomain (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V87", "evidence_id": "EV-PDB-7V87-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7V87", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V87" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local refinement of SARS-CoV-2 S-Kappa variant (B.1.617.1) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Angiotensin-converting enzyme 2 (ACE2) ectodomain (chains F,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V88", "evidence_id": "EV-PDB-7V88-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7V88", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V88" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, two ACE2-bound form" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Angiotensin-converting enzyme 2 (ACE2) ectodomain (chains F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V89", "evidence_id": "EV-PDB-7V89-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7V89", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V89" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Angiotensin-converting enzyme 2 (ACE2) ectodomain (chains F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V8A", "evidence_id": "EV-PDB-7V8A-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "7V8A", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V8A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form conformation 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Angiotensin-converting enzyme 2 (ACE2) ectodomain (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V8B", "evidence_id": "EV-PDB-7V8B-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7V8B", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V8B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local refinement of SARS-CoV-2 S-Delta variant (B.1.617.2) RBD and Angiotensin-converting enzyme 2 (ACE2) ectodomain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VIB", "evidence_id": "EV-PDB-7VIB-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7VIB", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VIB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human ACE2 and GX/P2V RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VX4", "evidence_id": "EV-PDB-7VX4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7VX4", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VX4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-RBD in SARS-CoV-2 Beta variant S-ACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VX5", "evidence_id": "EV-PDB-7VX5-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "7VX5", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VX5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-RBD in SARS-CoV-2 Kappa variant S-ACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VX9", "evidence_id": "EV-PDB-7VX9-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "7VX9", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VX9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Kappa variant spike protein in complex wth ACE2, state C1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VXA", "evidence_id": "EV-PDB-7VXA-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7VXA", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VXA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Kappa variant spike protein in complex with ACE2, state C2a" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VXB", "evidence_id": "EV-PDB-7VXB-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7VXB", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VXB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Kappa variant spike protein in C2b state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VXC", "evidence_id": "EV-PDB-7VXC-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7VXC", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VXC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Kappa variant spike protein in C3 state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VXD", "evidence_id": "EV-PDB-7VXD-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "7VXD", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VXD" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C1 state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VXF", "evidence_id": "EV-PDB-7VXF-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7VXF", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VXF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C2B state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VXK", "evidence_id": "EV-PDB-7VXK-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "7VXK", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VXK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C2A state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VXM", "evidence_id": "EV-PDB-7VXM-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7VXM", "doi": "10.1038/s41467-021-27350-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VXM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C3 state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W98", "evidence_id": "EV-PDB-7W98-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7W98", "doi": "10.1038/s41467-022-28528-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W98" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Delta S-ACE2-C1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W99", "evidence_id": "EV-PDB-7W99-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7W99", "doi": "10.1038/s41467-022-28528-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W99" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Delta S-ACE2-C2a" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W9B", "evidence_id": "EV-PDB-7W9B-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7W9B", "doi": "10.1038/s41467-022-28528-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W9B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Delta S-ACE2-C2b" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W9C", "evidence_id": "EV-PDB-7W9C-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7W9C", "doi": "10.1038/s41467-022-28528-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W9C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Delta S-ACE2-C3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W9I", "evidence_id": "EV-PDB-7W9I-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7W9I", "doi": "10.1038/s41467-022-28528-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W9I" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Delta S-RBD-ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WBL", "evidence_id": "EV-PDB-7WBL-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7WBL", "doi": "10.1016/j.cell.2022.01.001", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WBL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human ACE2 complexed with SARS-CoV-2 Omicron RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WBP", "evidence_id": "EV-PDB-7WBP-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7WBP", "doi": "10.1016/j.cell.2022.01.001", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WBP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron variant spike glycoprotein in complex with its receptor human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WBQ", "evidence_id": "EV-PDB-7WBQ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.34 }, "provenance": { "deposit_id": "7WBQ", "doi": "10.1016/j.cell.2022.01.001", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WBQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant spike glycoprotein in complex with its receptor human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WGB", "evidence_id": "EV-PDB-7WGB-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "7WGB", "doi": "10.1016/j.cell.2022.01.019", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WGB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Neutral Omicron Spike Trimer in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WGC", "evidence_id": "EV-PDB-7WGC-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7WGC", "doi": "10.1016/j.cell.2022.01.019", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WGC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Neutral Omicron Spike Trimer in complex with ACE2." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WHH", "evidence_id": "EV-PDB-7WHH-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "7WHH", "doi": "10.1038/s41422-022-00644-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WHH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SARS-CoV-2 omicron RBD and human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WK4", "evidence_id": "EV-PDB-7WK4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.69 }, "provenance": { "deposit_id": "7WK4", "doi": "10.1038/s41586-022-04581-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WK4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron spike protein with ACE2, C1 state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WK5", "evidence_id": "EV-PDB-7WK5-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.66 }, "provenance": { "deposit_id": "7WK5", "doi": "10.1101/2022.01.10.475532", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WK5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of Omicron S-ACE2, C2 state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WK6", "evidence_id": "EV-PDB-7WK6-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.67 }, "provenance": { "deposit_id": "7WK6", "doi": "10.1038/s41586-022-04581-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WK6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron spike protein with human ACE2 (focus refinement on RBD-1/ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WNM", "evidence_id": "EV-PDB-7WNM-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "7WNM", "doi": "10.1038/s41392-021-00821-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WNM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 Gamma variant receptor-binding domain complexed with high affinity human ACE2 mutant (T27F,R273Q)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPA", "evidence_id": "EV-PDB-7WPA-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "7WPA", "doi": "10.1126/science.abn8863", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron Variant SPIKE trimer complexed with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V85", "evidence_id": "EV-PDB-7V85-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7V85", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V85" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, two ACE2-bound form" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V81", "evidence_id": "EV-PDB-7V81-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7V81", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V81" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, two ACE2-bound form" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V7Z", "evidence_id": "EV-PDB-7V7Z-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "7V7Z", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V7Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-Beta variant (B.1.351) in complex with Angiotensin-converting enzyme 2 (ACE2) ectodomain, three ACE2-bound form" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7UFL", "evidence_id": "EV-PDB-7UFL-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.84 }, "provenance": { "deposit_id": "7UFL", "doi": "10.1073/pnas.2206509119", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7UFL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric omicron RBD (strain BA.2) complexed with chimeric mouse ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPB", "evidence_id": "EV-PDB-7WPB-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.79 }, "provenance": { "deposit_id": "7WPB", "doi": "10.1126/science.abn8863", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron Variant RBD complexed with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPC", "evidence_id": "EV-PDB-7WPC-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.57 }, "provenance": { "deposit_id": "7WPC", "doi": "10.1126/science.abn8863", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The second RBD of SARS-CoV-2 Omicron Variant in complexed with RBD-ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WS8", "evidence_id": "EV-PDB-7WS8-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7WS8", "doi": "10.1016/j.celrep.2022.110770", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WS8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WS9", "evidence_id": "EV-PDB-7WS9-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "7WS9", "doi": "10.1016/j.celrep.2022.110770", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WS9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WSA", "evidence_id": "EV-PDB-7WSA-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7WSA", "doi": "10.1016/j.celrep.2022.110770", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WSA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WVP", "evidence_id": "EV-PDB-7WVP-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "7WVP", "doi": "10.1038/s41586-022-04581-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WVP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron Spike protein with human ACE2 receptor, C2 state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WVQ", "evidence_id": "EV-PDB-7WVQ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.04 }, "provenance": { "deposit_id": "7WVQ", "doi": "10.1038/s41586-022-04581-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WVQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron Spike protein with human ACE2 receptor, C3 state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XAZ", "evidence_id": "EV-PDB-7XAZ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7XAZ", "doi": "10.1016/j.cell.2022.06.023", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XAZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Omicron BA.1.1 RBD complexed with hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XB0", "evidence_id": "EV-PDB-7XB0-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "7XB0", "doi": "10.1016/j.cell.2022.06.023", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XB0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Omicron BA.2 RBD complexed with hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XB1", "evidence_id": "EV-PDB-7XB1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "7XB1", "doi": "10.1016/j.cell.2022.06.023", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XB1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Omicron BA.3 RBD complexed with hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XBF", "evidence_id": "EV-PDB-7XBF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.51 }, "provenance": { "deposit_id": "7XBF", "doi": "10.15252/embj.2022111737", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XBF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The complex structure of RshSTT182/200 RBD-insert2 bound to human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XBG", "evidence_id": "EV-PDB-7XBG-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.37 }, "provenance": { "deposit_id": "7XBG", "doi": "10.15252/embj.2022111737", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XBG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The crystal structure of RshSTT182/200 RBD-insert2-T346R-Y496G mutant in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XBH", "evidence_id": "EV-PDB-7XBH-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.02 }, "provenance": { "deposit_id": "7XBH", "doi": "10.15252/embj.2022111737", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XBH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The complex structure of RshSTT182/200 RBD bound to human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XCH", "evidence_id": "EV-PDB-7XCH-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7XCH", "doi": "10.1038/s41467-022-32665-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XCH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (two-RBD-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XCI", "evidence_id": "EV-PDB-7XCI-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7XCI", "doi": "10.1038/s41467-022-32665-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XCI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron RBD in complex with human ACE2 ectodomain (local refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XCP", "evidence_id": "EV-PDB-7XCP-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.05 }, "provenance": { "deposit_id": "7XCP", "doi": "10.1038/s41467-022-32665-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XCP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of Omicron RBD complexed with ACE2 and 304 Fab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XID", "evidence_id": "EV-PDB-7XID-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7XID", "doi": "10.1016/j.isci.2022.104431", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XID" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XO7", "evidence_id": "EV-PDB-7XO7-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.38 }, "provenance": { "deposit_id": "7XO7", "doi": "10.1038/s41422-022-00672-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XO7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two human ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XO8", "evidence_id": "EV-PDB-7XO8-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.48 }, "provenance": { "deposit_id": "7XO8", "doi": "10.1038/s41422-022-00672-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XO8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three human ACE2 Bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XO9", "evidence_id": "EV-PDB-7XO9-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7XO9", "doi": "10.1038/s41422-022-00672-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XO9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.2 Variant RBD complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XWA", "evidence_id": "EV-PDB-7XWA-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.36 }, "provenance": { "deposit_id": "7XWA", "doi": "10.1016/j.cell.2022.09.018", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XWA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.4/5 variant spike protein in complex with its receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Y1Y", "evidence_id": "EV-PDB-7Y1Y-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7Y1Y", "doi": "10.3390/v15061398", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y1Y" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron BA.2) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Y1Z", "evidence_id": "EV-PDB-7Y1Z-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7Y1Z", "doi": "10.3390/v15061398", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y1Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron BA.3) in complex with three PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Y20", "evidence_id": "EV-PDB-7Y20-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "7Y20", "doi": "10.3390/v15061398", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y20" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron BA.3) in complex with two PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Y21", "evidence_id": "EV-PDB-7Y21-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7Y21", "doi": "10.3390/v15061398", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y21" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron BA.5) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3PH", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Y75", "evidence_id": "EV-PDB-7Y75-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "7Y75", "doi": "10.1038/s41421-022-00488-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y75" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SIT1-ACE2-BA.2 RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3PH", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Y76", "evidence_id": "EV-PDB-7Y76-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7Y76", "doi": "10.1038/s41421-022-00488-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y76" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SIT1-ACE2-BA.5 RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Y9Z", "evidence_id": "EV-PDB-7Y9Z-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "7Y9Z", "doi": "10.1038/s41467-022-32665-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y9Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (one-RBD-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YA0", "evidence_id": "EV-PDB-7YA0-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "7YA0", "doi": "10.1038/s41467-022-32665-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YA0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (S-6P-RRAR)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YA1", "evidence_id": "EV-PDB-7YA1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.11 }, "provenance": { "deposit_id": "7YA1", "doi": "10.1038/s41467-022-32665-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YA1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YDI", "evidence_id": "EV-PDB-7YDI-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.98 }, "provenance": { "deposit_id": "7YDI", "doi": "10.1038/s41564-022-01235-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YDI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2, focused refinement of RBD region" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains E,J,M)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YEG", "evidence_id": "EV-PDB-7YEG-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.73 }, "provenance": { "deposit_id": "7YEG", "doi": "10.1038/s41564-022-01235-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YEG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YHW", "evidence_id": "EV-PDB-7YHW-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.09 }, "provenance": { "deposit_id": "7YHW", "doi": "10.1038/s41467-023-39942-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YHW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YJ3", "evidence_id": "EV-PDB-7YJ3-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "7YJ3", "doi": "10.1038/s41467-023-39942-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YJ3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with human ACE2 (local refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YR2", "evidence_id": "EV-PDB-7YR2-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7YR2", "doi": "10.1016/j.chom.2022.09.018", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YR2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YR3", "evidence_id": "EV-PDB-7YR3-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.52 }, "provenance": { "deposit_id": "7YR3", "doi": "10.1016/j.chom.2022.09.018", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YR3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YR4", "evidence_id": "EV-PDB-7YR4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.12 }, "provenance": { "deposit_id": "7YR4", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YR4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(interface)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7ZDQ", "evidence_id": "EV-PDB-7ZDQ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7ZDQ", "doi": "10.1371/journal.ppat.1010733", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7ZDQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of Human ACE2 bound to a high-affinity SARS CoV-2 mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7ZF7", "evidence_id": "EV-PDB-7ZF7-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.46 }, "provenance": { "deposit_id": "7ZF7", "doi": "10.1016/j.cell.2022.05.014", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7ZF7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SARS-CoV-2 Omicron BA.2 RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8AQS", "evidence_id": "EV-PDB-8AQS-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.92 }, "provenance": { "deposit_id": "8AQS", "doi": "10.1371/journal.ppat.1011206", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8AQS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "NAG", "PGE" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ASY", "evidence_id": "EV-PDB-8ASY-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "8ASY", "doi": "10.1016/j.celrep.2022.111903", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ASY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LFI" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8B9P", "evidence_id": "EV-PDB-8B9P-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.11 }, "provenance": { "deposit_id": "8B9P", "doi": "10.1021/acs.jmedchem.3c00710", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8B9P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2 in complex with bicyclic peptide inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LFI" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8BFW", "evidence_id": "EV-PDB-8BFW-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.33 }, "provenance": { "deposit_id": "8BFW", "doi": "10.1021/acs.jmedchem.3c00710", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8BFW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The structures of Ace2 in complex with bicyclic peptide inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LFI", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8BN1", "evidence_id": "EV-PDB-8BN1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.61 }, "provenance": { "deposit_id": "8BN1", "doi": "10.1021/acs.jmedchem.3c00710", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8BN1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The structures of Ace2 in complex with bicyclic peptide inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LFI", "NA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8BYJ", "evidence_id": "EV-PDB-8BYJ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.07 }, "provenance": { "deposit_id": "8BYJ", "doi": "10.1021/acs.jmedchem.3c00710", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8BYJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The structures of Ace2 in complex with bicyclic peptide inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DF5", "evidence_id": "EV-PDB-8DF5-3", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8DF5", "doi": "10.1126/science.abo7896", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DF5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLJ", "evidence_id": "EV-PDB-8DLJ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.91 }, "provenance": { "deposit_id": "8DLJ", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLK", "evidence_id": "EV-PDB-8DLK-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8DLK", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLM", "evidence_id": "EV-PDB-8DLM-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.89 }, "provenance": { "deposit_id": "8DLM", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLN", "evidence_id": "EV-PDB-8DLN-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8DLN", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLP", "evidence_id": "EV-PDB-8DLP-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.64 }, "provenance": { "deposit_id": "8DLP", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLQ", "evidence_id": "EV-PDB-8DLQ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "8DLQ", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLU", "evidence_id": "EV-PDB-8DLU-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "8DLU", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DLV", "evidence_id": "EV-PDB-8DLV-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.11 }, "provenance": { "deposit_id": "8DLV", "doi": "10.1038/s41467-022-32262-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DLV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DM6", "evidence_id": "EV-PDB-8DM6-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "8DM6", "doi": "10.1016/j.celrep.2022.111964", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DM6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DV2", "evidence_id": "EV-PDB-8DV2-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8DV2", "doi": "10.1016/j.str.2023.01.009", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DV2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8FXB", "evidence_id": "EV-PDB-8FXB-3", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8FXB", "doi": "10.1038/s41586-023-06487-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8FXB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 XBB.1 spike RBD bound to the human ACE2 ectodomain and the S309 neutralizing antibody Fab fragment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8FXC", "evidence_id": "EV-PDB-8FXC-3", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8FXC", "doi": "10.1038/s41586-023-06487-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8FXC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 BQ.1.1 spike RBD bound to the human ACE2 ectodomain and the S309 neutralizing antibody Fab fragment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8H5C", "evidence_id": "EV-PDB-8H5C-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8H5C", "doi": "10.1038/s41467-023-39942-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8H5C" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SARS-CoV-2 Omicron BA.2.75 RBD in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8HRK", "evidence_id": "EV-PDB-8HRK-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8HRK", "doi": "10.1038/s41467-024-51696-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8HRK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Delta S-RBD-ACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8HRL", "evidence_id": "EV-PDB-8HRL-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "8HRL", "doi": "10.1038/s41467-024-51696-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8HRL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Delta S-RBD-ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8HRN", "evidence_id": "EV-PDB-8HRN-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "8HRN", "doi": "10.1038/s41467-024-51696-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8HRN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "PRO", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I91", "evidence_id": "EV-PDB-8I91-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8I91", "doi": "10.1038/s41421-023-00596-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I91" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-SIT1 complex bound with proline" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GLN", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I92", "evidence_id": "EV-PDB-8I92-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8I92", "doi": "10.1038/s41421-023-00596-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I92" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-B0AT1 complex bound with glutamine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MET", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I93", "evidence_id": "EV-PDB-8I93-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8I93", "doi": "10.1038/s41421-023-00596-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I93" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ACE2-B0AT1 complex bound with methionine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I9B", "evidence_id": "EV-PDB-8I9B-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8I9B", "doi": "10.1038/s41421-023-00607-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I9B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron BA.2.75) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I9C", "evidence_id": "EV-PDB-8I9C-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.85 }, "provenance": { "deposit_id": "8I9C", "doi": "10.1038/s41421-023-00607-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I9C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron BF.7) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I9D", "evidence_id": "EV-PDB-8I9D-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.95 }, "provenance": { "deposit_id": "8I9D", "doi": "10.1038/s41421-023-00607-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I9D" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-ECD (Omicron XBB.1) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I9E", "evidence_id": "EV-PDB-8I9E-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8I9E", "doi": "10.3390/v15061398", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I9E" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-RBD(Omicron BA.3) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I9F", "evidence_id": "EV-PDB-8I9F-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8I9F", "doi": "10.1038/s41421-023-00607-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I9F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-RBD (Omicron BA.2.75) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I9G", "evidence_id": "EV-PDB-8I9G-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8I9G", "doi": "10.1038/s41421-023-00607-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I9G" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-RBD (Omicron BF.7) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I9H", "evidence_id": "EV-PDB-8I9H-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8I9H", "doi": "10.1038/s41421-023-00607-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I9H" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S-RBD (Omicron XBB.1) in complex with PD of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8IOU", "evidence_id": "EV-PDB-8IOU-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.18 }, "provenance": { "deposit_id": "8IOU", "doi": "10.1038/s41467-023-38435-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8IOU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 XBB.1 spike glycoprotein in complex with ACE2 (1-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8IOV", "evidence_id": "EV-PDB-8IOV-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "8IOV", "doi": "10.1038/s41467-023-38435-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8IOV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 XBB.1 spike RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JWH", "evidence_id": "EV-PDB-8JWH-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.34 }, "provenance": { "deposit_id": "8JWH", "doi": "10.1038/s41592-024-02247-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JWH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of apo-state huamn angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JYO", "evidence_id": "EV-PDB-8JYO-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8JYO", "doi": "10.1038/s41467-024-45274-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JYO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (2-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JYP", "evidence_id": "EV-PDB-8JYP-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.38 }, "provenance": { "deposit_id": "8JYP", "doi": "10.1038/s41467-024-45274-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JYP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 XBB.1.5 spike RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "NDG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8P2Y", "evidence_id": "EV-PDB-8P2Y-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.46 }, "provenance": { "deposit_id": "8P2Y", "doi": "10.1038/s41467-024-48921-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8P2Y" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human SIT1:ACE2 complex (closed PD conformation)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "YCP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8P2Z", "evidence_id": "EV-PDB-8P2Z-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8P2Z", "doi": "10.1038/s41467-024-48921-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8P2Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human SIT1 bound to L-pipecolate (focussed map / refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QSQ", "evidence_id": "EV-PDB-8QSQ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "8QSQ", "doi": "10.1016/j.xcrm.2024.101553", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QSQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined SARS-CoV-2 BA-2.86 Spike receptor binding domain (RBD) complexed with angiotensin converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8S9G", "evidence_id": "EV-PDB-8S9G-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8S9G", "doi": "10.1038/s41586-023-06487-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8S9G" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 BN.1 spike RBD bound to the human ACE2 ectodomain and the S309 neutralizing antibody Fab fragment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SPH", "evidence_id": "EV-PDB-8SPH-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.71 }, "provenance": { "deposit_id": "8SPH", "doi": "10.1128/jvi.00822-23", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SPH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric omicron RBD (strain XBB.1) complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SPI", "evidence_id": "EV-PDB-8SPI-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.06 }, "provenance": { "deposit_id": "8SPI", "doi": "10.1128/jvi.00822-23", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SPI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric omicron RBD (strain XBB.1.5) complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8TOQ", "evidence_id": "EV-PDB-8TOQ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "8TOQ", "doi": "10.1021/acschembio.3c00568", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8TOQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2-peptide 1 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8TOR", "evidence_id": "EV-PDB-8TOR-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "8TOR", "doi": "10.1021/acschembio.3c00568", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8TOR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2-peptide 2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "NAG", "ZN", "branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8TOS", "evidence_id": "EV-PDB-8TOS-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.35 }, "provenance": { "deposit_id": "8TOS", "doi": "10.1021/acschembio.3c00568", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8TOS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2-peptide 6 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8TOT", "evidence_id": "EV-PDB-8TOT-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "8TOT", "doi": "10.1021/acschembio.3c00568", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8TOT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2-peptide2 complex crystal form 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8TOU", "evidence_id": "EV-PDB-8TOU-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8TOU", "doi": "10.1021/acschembio.3c00568", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8TOU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2-peptide 2 complex crystal form 3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "NDG", "YCP", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8P31", "evidence_id": "EV-PDB-8P31-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.24 }, "provenance": { "deposit_id": "8P31", "doi": "10.1038/s41467-024-48921-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8P31" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human SIT1:ACE2 complex (closed PD conformation) bound to L-pipecolate" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "NDG", "YCP", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8P30", "evidence_id": "EV-PDB-8P30-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "8P30", "doi": "10.1038/s41467-024-48921-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8P30" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human SIT1:ACE2 complex (open PD conformation) bound to L-pipecolate" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "NDG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8P2X", "evidence_id": "EV-PDB-8P2X-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.59 }, "provenance": { "deposit_id": "8P2X", "doi": "10.1038/s41467-024-48921-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8P2X" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human SIT1:ACE2 complex (open PD conformation)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8P2W", "evidence_id": "EV-PDB-8P2W-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.76 }, "provenance": { "deposit_id": "8P2W", "doi": "10.1038/s41467-024-48921-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8P2W" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human SIT1 (focussed map / refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JYN", "evidence_id": "EV-PDB-8JYN-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8JYN", "doi": "10.1038/s41467-024-45274-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JYN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (1-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "SO4", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JJE", "evidence_id": "EV-PDB-8JJE-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8JJE", "doi": "10.1126/scitranslmed.adi2623", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JJE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "RBD of SARS-CoV2 spike protein with ACE2 decoy" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8IF2", "evidence_id": "EV-PDB-8IF2-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.78 }, "provenance": { "deposit_id": "8IF2", "doi": "10.1038/s41467-023-38188-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8IF2" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BQ.1.1 variant spike protein in complex with its receptor ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8HRU", "evidence_id": "EV-PDB-8HRU-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "8HRU", "doi": "10.1038/s41467-024-51696-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8HRU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8H06", "evidence_id": "EV-PDB-8H06-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.66 }, "provenance": { "deposit_id": "8H06", "doi": "10.1038/s41467-023-39942-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8H06" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 RBD in complex with human ACE2 (local refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8E7M", "evidence_id": "EV-PDB-8E7M-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8E7M", "doi": "10.1101/2022.08.24.505169", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8E7M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of the human ACE2 receptor in complex with antibody Fab fragment, 05B04" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion,Immunoglobulin gamma-1 heavy chain (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DV1", "evidence_id": "EV-PDB-8DV1-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8DV1", "doi": "10.1016/j.str.2023.01.009", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DV1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DM5", "evidence_id": "EV-PDB-8DM5-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.51 }, "provenance": { "deposit_id": "8DM5", "doi": "10.1016/j.celrep.2022.111964", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DM5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NA", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UZE", "evidence_id": "EV-PDB-8UZE-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.03 }, "provenance": { "deposit_id": "8UZE", "doi": "10.1073/pnas.2322600121", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UZE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric bat coronavirus BANAL-20-236 RBD complexed with chimeric mouse ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WLZ", "evidence_id": "EV-PDB-8WLZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.45 }, "provenance": { "deposit_id": "8WLZ", "doi": "10.1128/jvi.00342-24", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WLZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the WIV1 S-hACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WRO", "evidence_id": "EV-PDB-8WRO-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "8WRO", "doi": "10.1371/journal.ppat.1011868", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WRO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "XBB.1.5.10 spike protein in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WTJ", "evidence_id": "EV-PDB-8WTJ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.64 }, "provenance": { "deposit_id": "8WTJ", "doi": "10.1371/journal.ppat.1011868", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WTJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "XBB.1.5.70 spike protein in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XLM", "evidence_id": "EV-PDB-8XLM-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.22 }, "provenance": { "deposit_id": "8XLM", "doi": "10.1111/1348-0421.13165", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XLM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of the SARS-CoV-2 EG.5.1 spike glycoprotein in complex with ACE2 (1-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XLN", "evidence_id": "EV-PDB-8XLN-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.78 }, "provenance": { "deposit_id": "8XLN", "doi": "10.1111/1348-0421.13165", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XLN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of the SARS-CoV-2 EG.5.1 spike RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,O)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XUY", "evidence_id": "EV-PDB-8XUY-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "8XUY", "doi": "10.1038/s41467-024-52808-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XUY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 BA.2.86 spike glycoprotein in complex with ACE2 (2-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XUZ", "evidence_id": "EV-PDB-8XUZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.05 }, "provenance": { "deposit_id": "8XUZ", "doi": "10.1038/s41467-024-52808-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XUZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 BA.2.86 spike glycoprotein in complex with ACE2 (2-up and 1-down state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XV0", "evidence_id": "EV-PDB-8XV0-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8XV0", "doi": "10.1038/s41467-024-52808-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XV0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 BA.2.86 spike RBD in complex with ACE2 (up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XV1", "evidence_id": "EV-PDB-8XV1-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.05 }, "provenance": { "deposit_id": "8XV1", "doi": "10.1038/s41467-024-52808-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XV1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 BA.2.86 spike RBD in complex with ACE2 (down state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XVM", "evidence_id": "EV-PDB-8XVM-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "8XVM", "doi": "10.1038/s41467-024-52808-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XVM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 BA.2.86 spike glycoprotein in complex with ACE2 (3-up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XYO", "evidence_id": "EV-PDB-8XYO-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8XYO", "doi": "10.1128/jvi.00283-25", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XYO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of CX1 receptor binding domain in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XYG", "evidence_id": "EV-PDB-8XYG-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.64 }, "provenance": { "deposit_id": "8XYG", "doi": "10.1016/j.virol.2024.110241", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XYG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SARS-CoV-2 BQ.1.1 RBD and human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XYE", "evidence_id": "EV-PDB-8XYE-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.32 }, "provenance": { "deposit_id": "8XYE", "doi": "10.1016/j.virol.2024.110241", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XYE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SARS-CoV-2 BA.4 RBD and human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XY9", "evidence_id": "EV-PDB-8XY9-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.64 }, "provenance": { "deposit_id": "8XY9", "doi": "10.1016/j.virol.2024.110241", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XY9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SARS-CoV-2 BF.7 RBD and human ACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XXW", "evidence_id": "EV-PDB-8XXW-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.03 }, "provenance": { "deposit_id": "8XXW", "doi": "10.1016/j.celrep.2024.114235", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XXW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Fab M2-7 complexed with SARS-Cov2 RBD and human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XSJ", "evidence_id": "EV-PDB-8XSJ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.61 }, "provenance": { "deposit_id": "8XSJ", "doi": "10.1016/j.celrep.2024.114338", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XSJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4 RBD + IMCAS-316 + ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XSF", "evidence_id": "EV-PDB-8XSF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.16 }, "provenance": { "deposit_id": "8XSF", "doi": "10.1016/j.celrep.2024.114338", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XSF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 RBD + IMCAS-364 + hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XNK", "evidence_id": "EV-PDB-8XNK-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.78 }, "provenance": { "deposit_id": "8XNK", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XNK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron HV.1 spike protein(6P) in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XNF", "evidence_id": "EV-PDB-8XNF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.26 }, "provenance": { "deposit_id": "8XNF", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XNF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 spike protein(6P) in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XN5", "evidence_id": "EV-PDB-8XN5-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.87 }, "provenance": { "deposit_id": "8XN5", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XN5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron EG.5.1 spike protein(6P) in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XN3", "evidence_id": "EV-PDB-8XN3-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.64 }, "provenance": { "deposit_id": "8XN3", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XN3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron HV.1 RBD in complex with human ACE2 (local refinement from the spike protein)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XN2", "evidence_id": "EV-PDB-8XN2-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.79 }, "provenance": { "deposit_id": "8XN2", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XN2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron EG.5.1 RBD in complex with human ACE2 (local refined from the spike protein)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2,Green fluorescent protein (Fragment) (chains I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XAL", "evidence_id": "EV-PDB-8XAL-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8XAL", "doi": "10.1172/jci.insight.179726", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XAL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S-BQ.1 in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains T,X,Z)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WYH", "evidence_id": "EV-PDB-8WYH-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8WYH", "doi": "10.1038/s41467-024-51973-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WYH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The global map of Omicron Subvariants Spike with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WTD", "evidence_id": "EV-PDB-8WTD-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.06 }, "provenance": { "deposit_id": "8WTD", "doi": "10.1371/journal.ppat.1011868", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WTD" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "XBB.1.5.10 RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WSR", "evidence_id": "EV-PDB-8WSR-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.99 }, "provenance": { "deposit_id": "8WSR", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WSR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The structure of LS1_RBD/hACE2 protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WRM", "evidence_id": "EV-PDB-8WRM-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.34 }, "provenance": { "deposit_id": "8WRM", "doi": "10.1371/journal.ppat.1011868", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WRM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "XBB.1.5 spike protein in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WRL", "evidence_id": "EV-PDB-8WRL-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.36 }, "provenance": { "deposit_id": "8WRL", "doi": "10.1371/journal.ppat.1011868", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WRL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "XBB.1.5 RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WRH", "evidence_id": "EV-PDB-8WRH-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.08 }, "provenance": { "deposit_id": "8WRH", "doi": "10.1371/journal.ppat.1011868", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WRH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 XBB.1.5.70 in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WP8", "evidence_id": "EV-PDB-8WP8-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.89 }, "provenance": { "deposit_id": "8WP8", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WP8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "TGI", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WM3", "evidence_id": "EV-PDB-8WM3-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.34 }, "provenance": { "deposit_id": "8WM3", "doi": "10.1016/j.jbc.2024.107687", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WM3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of ACE2-SIT1 complex with tiagabine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WHZ", "evidence_id": "EV-PDB-8WHZ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.93 }, "provenance": { "deposit_id": "8WHZ", "doi": "10.1093/nsr/nwae206", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WHZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "BA.2.86 RBD in complex with hACE2 (local refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WHU", "evidence_id": "EV-PDB-8WHU-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8WHU", "doi": "10.1093/nsr/nwae206", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WHU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Spike Trimer of BA.2.86 in complex with two hACE2s" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WHS", "evidence_id": "EV-PDB-8WHS-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.33 }, "provenance": { "deposit_id": "8WHS", "doi": "10.1093/nsr/nwae206", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WHS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Spike Trimer of BA.2.86 in complex with one hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WGW", "evidence_id": "EV-PDB-8WGW-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8WGW", "doi": "10.1038/s41590-024-01776-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WGW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local refinement of RBD-ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WGV", "evidence_id": "EV-PDB-8WGV-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.92 }, "provenance": { "deposit_id": "8WGV", "doi": "10.1038/s41590-024-01776-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WGV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "BA.2(S375) Spike (S6P)/hACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WE4", "evidence_id": "EV-PDB-8WE4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.91 }, "provenance": { "deposit_id": "8WE4", "doi": "10.1038/s44318-024-00062-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WE4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron XBB.1.5 RBD complexed with human ACE2 and S304" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WE1", "evidence_id": "EV-PDB-8WE1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.47 }, "provenance": { "deposit_id": "8WE1", "doi": "10.1038/s44318-024-00062-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WE1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BF.7 RBD complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WE0", "evidence_id": "EV-PDB-8WE0-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "8WE0", "doi": "10.1038/s44318-024-00062-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WE0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron XBB RBD complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WDZ", "evidence_id": "EV-PDB-8WDZ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.71 }, "provenance": { "deposit_id": "8WDZ", "doi": "10.1038/s44318-024-00062-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WDZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BQ.1 RBD complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WDY", "evidence_id": "EV-PDB-8WDY-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.69 }, "provenance": { "deposit_id": "8WDY", "doi": "10.1038/s44318-024-00062-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WDY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BQ.1.1 RBD complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 17.85 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WDS", "evidence_id": "EV-PDB-8WDS-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8WDS", "doi": "10.1038/s44318-024-00062-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WDS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of BF.7 RBD complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WDR", "evidence_id": "EV-PDB-8WDR-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.47 }, "provenance": { "deposit_id": "8WDR", "doi": "10.1038/s44318-024-00062-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WDR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of BQ.1.1 RBD complexed with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "XF0", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WBZ", "evidence_id": "EV-PDB-8WBZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8WBZ", "doi": "10.1038/s41467-024-51748-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WBZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of ACE2-B0AT1 complex with JX225" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "WM8", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8WBY", "evidence_id": "EV-PDB-8WBY-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.18 }, "provenance": { "deposit_id": "8WBY", "doi": "10.1038/s41467-024-51748-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8WBY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of ACE2-B0AT1 complex with JX98" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme,Processed angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8VQR", "evidence_id": "EV-PDB-8VQR-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.565 }, "provenance": { "deposit_id": "8VQR", "doi": "10.1371/journal.ppat.1012204", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8VQR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric SARS-CoV-2 RBD complexed with chimeric raccoon dog ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8VKP", "evidence_id": "EV-PDB-8VKP-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "8VKP", "doi": "10.1038/s41467-024-46104-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8VKP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8VKO", "evidence_id": "EV-PDB-8VKO-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.68 }, "provenance": { "deposit_id": "8VKO", "doi": "10.1038/s41467-024-46104-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8VKO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UZF", "evidence_id": "EV-PDB-8UZF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.283 }, "provenance": { "deposit_id": "8UZF", "doi": "10.1073/pnas.2322600121", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UZF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of chimeric RaTG13 RBD complexed with chimeric mouse ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Y16", "evidence_id": "EV-PDB-8Y16-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.98 }, "provenance": { "deposit_id": "8Y16", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Y16" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron JN.1 spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Y18", "evidence_id": "EV-PDB-8Y18-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8Y18", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Y18" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron JN.1 RBD in complex with human ACE2 (local refinement from the spike protein)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Z4X", "evidence_id": "EV-PDB-8Z4X-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8Z4X", "doi": "10.1016/j.cell.2025.01.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Z4X" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 D614G S with two ACE2 receptors binding (RB2) in prefusion conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Z64", "evidence_id": "EV-PDB-8Z64-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.53 }, "provenance": { "deposit_id": "8Z64", "doi": "10.1016/j.cell.2025.01.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Z64" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 D614G S with three ACE2 receptors binding (RB3) in prefusion conformation (focused refinement of NTD-SD1-RBD-ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Z6A", "evidence_id": "EV-PDB-8Z6A-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.99 }, "provenance": { "deposit_id": "8Z6A", "doi": "10.1016/j.cell.2025.01.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Z6A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 D614G S with three ACE2 receptors binding (RB3) in prefusion conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Z7B", "evidence_id": "EV-PDB-8Z7B-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8Z7B", "doi": "10.1016/j.cell.2025.01.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Z7B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S trimer in the early fusion intermediate conformation (E-FIC) (focused refinement of NTD-SD1-RBD-ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Z7P", "evidence_id": "EV-PDB-8Z7P-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.45 }, "provenance": { "deposit_id": "8Z7P", "doi": "10.1016/j.cell.2025.01.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Z7P" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 S trimer in the early fusion intermediate conformation (E-FIC)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Collagen alpha-1(XVIII) chain,Processed angiotensin-converting enzyme 2 (chains A,C,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BNG", "evidence_id": "EV-PDB-9BNG-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.73 }, "provenance": { "deposit_id": "9BNG", "doi": "10.1038/s42003-025-08819-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BNG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike HexaPro protein in complex with T18A trimeric antagonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9IU1", "evidence_id": "EV-PDB-9IU1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.3 }, "provenance": { "deposit_id": "9IU1", "doi": "10.1038/s41467-024-52808-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9IU1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of SARS-CoV-2 JN.1 spike RBD in complex with ACE2 (up state)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9IUP", "evidence_id": "EV-PDB-9IUP-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9IUP", "doi": "10.1038/s41421-024-00752-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9IUP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "KP.3 RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9IUU", "evidence_id": "EV-PDB-9IUU-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "9IUU", "doi": "10.1038/s41421-024-00752-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9IUU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "JN.1 RBD with Q493E in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9JJ6", "evidence_id": "EV-PDB-9JJ6-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.94 }, "provenance": { "deposit_id": "9JJ6", "doi": "10.1016/j.cell.2025.01.042", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9JJ6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "BtHKU5-CoV-2-441 Spike RBD domain binding to hACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA", "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KXW", "evidence_id": "EV-PDB-9KXW-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.66 }, "provenance": { "deposit_id": "9KXW", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KXW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1L6U", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KXY", "evidence_id": "EV-PDB-9KXY-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.82 }, "provenance": { "deposit_id": "9KXY", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KXY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2 complex with compound1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9LDJ", "evidence_id": "EV-PDB-9LDJ-4", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 6.21 }, "provenance": { "deposit_id": "9LDJ", "doi": "10.1038/s41586-026-10462-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9LDJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 wide-type S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UE7", "evidence_id": "EV-PDB-9UE7-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.27 }, "provenance": { "deposit_id": "9UE7", "doi": "10.1038/s41467-025-66018-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UE7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 KP.2 spike in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XHZ", "evidence_id": "EV-PDB-9XHZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 5.28 }, "provenance": { "deposit_id": "9XHZ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XHZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with C092 Fab and ACE2 (2 RBD up)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI0", "evidence_id": "EV-PDB-9XI0-4", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.98 }, "provenance": { "deposit_id": "9XI0", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with C092 Fab and ACE2 (3 RBD up)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XHY", "evidence_id": "EV-PDB-9XHY-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.84 }, "provenance": { "deposit_id": "9XHY", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XHY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with C092 Fab and ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VLT", "evidence_id": "EV-PDB-9VLT-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 5.65 }, "provenance": { "deposit_id": "9VLT", "doi": "10.1038/s41586-026-10462-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VLT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 XBB.1.5 S trimer in the early fusion intermediate conformation (E-FIC) complexed with ACE2 and 76E1-Fab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "PHE", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VA2", "evidence_id": "EV-PDB-9VA2-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.87 }, "provenance": { "deposit_id": "9VA2", "doi": "10.26599/OSHM.2025.9610033", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VA2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of the ACE2-B0AT1 bound with Phenylalanine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "TRP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VA1", "evidence_id": "EV-PDB-9VA1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.24 }, "provenance": { "deposit_id": "9VA1", "doi": "10.26599/OSHM.2025.9610033", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VA1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of the ACE2-B0AT1 bound with tryptophan" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UE6", "evidence_id": "EV-PDB-9UE6-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "9UE6", "doi": "10.1038/s41467-025-66018-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UE6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 KP.2 spike RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9U4O", "evidence_id": "EV-PDB-9U4O-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "9U4O", "doi": "10.1016/j.cell.2026.04.019", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9U4O" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM Structure of Human ACE2 Complexed with RacCS20637 RBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MLA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPA", "evidence_id": "EV-PDB-9SPA-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.79 }, "provenance": { "deposit_id": "9SPA", "doi": "10.1021/acs.jmedchem.5c02876", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Apo ACE2 extracellular domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B,D,G)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RVT", "evidence_id": "EV-PDB-9RVT-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.39 }, "provenance": { "deposit_id": "9RVT", "doi": "10.1021/acs.jmedchem.5c02876", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RVT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ACE2 extracellular domain in complex with the macrocyclic peptide GR1.4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "2PE", "CL", "EDO", "IPA", "NA", "NAG", "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RVA", "evidence_id": "EV-PDB-9RVA-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "9RVA", "doi": "10.1016/j.yjsbx.2026.100145", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RVA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the extracellular part of human ACE2 in complex with the macrocyclic peptide WJL-63" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9R19", "evidence_id": "EV-PDB-9R19-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.69 }, "provenance": { "deposit_id": "9R19", "doi": "10.1038/s41467-025-65144-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9R19" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human ACE2 in complex with VHH B07 and VHH B10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KY1", "evidence_id": "EV-PDB-9KY1-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "9KY1", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KY1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2 complex with compound1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1L6W", "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KY0", "evidence_id": "EV-PDB-9KY0-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.68 }, "provenance": { "deposit_id": "9KY0", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KY0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2 complex with compound3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1L6V", "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KXZ", "evidence_id": "EV-PDB-9KXZ-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "9KXZ", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KXZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2 complex with compound1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1L6W", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KXV", "evidence_id": "EV-PDB-9KXV-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.71 }, "provenance": { "deposit_id": "9KXV", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KXV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2 complex with compound3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1L6V", "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KXU", "evidence_id": "EV-PDB-9KXU-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.87 }, "provenance": { "deposit_id": "9KXU", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KXU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2 complex with compound 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1L6U", "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KXT", "evidence_id": "EV-PDB-9KXT-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "9KXT", "doi": "10.1038/s42003-026-10535-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KXT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human B0AT1-ACE2 complex with compound1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9J62", "evidence_id": "EV-PDB-9J62-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.76 }, "provenance": { "deposit_id": "9J62", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9J62" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of Bat SARS-like coronavirus Khosta-2 spike protein in complex with human ACE2 (local refined)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9IUQ", "evidence_id": "EV-PDB-9IUQ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9IUQ", "doi": "10.1038/s41421-024-00752-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9IUQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "KP.2 RBD in complex with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1IDX", "CL", "EDO", "NA", "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FMM", "evidence_id": "EV-PDB-9FMM-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "9FMM", "doi": "10.1007/s00259-024-06831-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FMM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of human ACE2 in complex with a fluorinated small molecule inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ELF", "evidence_id": "EV-PDB-9ELF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.88 }, "provenance": { "deposit_id": "9ELF", "doi": "10.1016/j.celrep.2025.115941", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ELF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike protein in complex with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ELE", "evidence_id": "EV-PDB-9ELE-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.16 }, "provenance": { "deposit_id": "9ELE", "doi": "10.1016/j.celrep.2025.115941", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ELE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 RBD in complex with human ACE2 (local refinement of RBD and hACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Collagen alpha-1(XVIII) chain,Processed angiotensin-converting enzyme 2 (chains A,C,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BNF", "evidence_id": "EV-PDB-9BNF-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.33 }, "provenance": { "deposit_id": "9BNF", "doi": "10.1038/s42003-025-08819-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BNF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike HexaPro protein in complex with T5A trimeric antagonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Collagen alpha-1(XVIII) chain,Processed angiotensin-converting enzyme 2 (chains A,C,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BNE", "evidence_id": "EV-PDB-9BNE-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.43 }, "provenance": { "deposit_id": "9BNE", "doi": "10.1038/s42003-025-08819-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BNE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike HexaPro protein in complex with T3A trimeric antagonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Collagen alpha-1(XVIII) chain,Processed angiotensin-converting enzyme 2 (chains A,C,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BND", "evidence_id": "EV-PDB-9BND-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.19 }, "provenance": { "deposit_id": "9BND", "doi": "10.1038/s42003-025-08819-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BND" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 spike HexaPro protein in complex with T0A trimeric antagonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZBQ", "evidence_id": "EV-PDB-8ZBQ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.03 }, "provenance": { "deposit_id": "8ZBQ", "doi": "10.1038/s41467-024-51973-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ZBQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local map of Omicron Subvariant JN.1 RBD with ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Z3W", "evidence_id": "EV-PDB-8Z3W-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.45 }, "provenance": { "deposit_id": "8Z3W", "doi": "10.1016/j.cell.2025.01.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Z3W" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 D614G S with one ACE2 receptor binding (RB1) in prefusion conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8YZJ", "evidence_id": "EV-PDB-8YZJ-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "8YZJ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8YZJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The structure of Banal-52 RBD and hACE2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8YZE", "evidence_id": "EV-PDB-8YZE-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.06 }, "provenance": { "deposit_id": "8YZE", "doi": "10.1038/s41467-024-53033-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8YZE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The JN.1 spike protein (S) in complex with ACE2." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8YZD", "evidence_id": "EV-PDB-8YZD-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.07 }, "provenance": { "deposit_id": "8YZD", "doi": "10.1038/s41467-024-53033-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8YZD" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of JN.1 RBD protein in complex with ACE2." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8YZC", "evidence_id": "EV-PDB-8YZC-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8YZC", "doi": "10.1038/s41467-024-53033-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8YZC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of BA.2.86 spike protein in complex with ACE2." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8YZB", "evidence_id": "EV-PDB-8YZB-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "8YZB", "doi": "10.1038/s41467-024-53033-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8YZB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "BA.2.86 RBD protein in complex with ACE2." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Y6A", "evidence_id": "EV-PDB-8Y6A-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.72 }, "provenance": { "deposit_id": "8Y6A", "doi": "10.1016/j.str.2024.06.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Y6A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2 and S309 Fab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI1", "evidence_id": "EV-PDB-9XI1-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.58 }, "provenance": { "deposit_id": "9XI1", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with C092 Fab and ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI2", "evidence_id": "EV-PDB-9XI2-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "9XI2", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with C807 Fab and ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI3", "evidence_id": "EV-PDB-9XI3-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.74 }, "provenance": { "deposit_id": "9XI3", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with C807 Fab and ACE2 (3 RBD up)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI4", "evidence_id": "EV-PDB-9XI4-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "9XI4", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with BD56-104 Fab and ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI5", "evidence_id": "EV-PDB-9XI5-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.06 }, "provenance": { "deposit_id": "9XI5", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with BD56-104 Fab and ACE2 (3 RBD up)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI6", "evidence_id": "EV-PDB-9XI6-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "9XI6", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike RBD in complex with BD56-597 Fab and ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Processed angiotensin-converting enzyme 2 (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XI7", "evidence_id": "EV-PDB-9XI7-2", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.22 }, "provenance": { "deposit_id": "9XI7", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XI7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SARS-CoV-2 Omicron BA.4/5 spike trimer in complex with BD56-597 Fab and ACE2 (3 RBD up)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YSR", "evidence_id": "EV-PDB-9YSR-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.63 }, "provenance": { "deposit_id": "9YSR", "doi": "10.1016/j.celrep.2026.117812", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YSR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local refinement of hACE2/SARS-CoV-2 BA.3.2.1 spike, conformation 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Angiotensin-converting enzyme 2 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YSS", "evidence_id": "EV-PDB-9YSS-1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.67 }, "provenance": { "deposit_id": "9YSS", "doi": "10.1016/j.celrep.2026.117812", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YSS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Local refinement of hACE2/SARS-CoV-2 LP.8.1 spike, conformation 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 2.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34650", "evidence_id": "EV-BMRB-34650", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34650", "doi": "10.13018/BMR34650", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34650" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "NMR structure of human ACE2 21-42 fragment in HFIP/water 50/50 v/v" }, { "conditions": { "applied_force_pn": null, "buffer": "50mM Tris, 200mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 27.48 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 10.0 }, "construct": { "description": "Angiotensin Converting Enzyme2", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDXW6/", "evidence_id": "EV-SASBDB-SASDXW6", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "radius_of_gyration", "uncertainty": 1.752, "unit": "nm", "value": 5.446 }, "provenance": { "deposit_id": "SASDXW6", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDXW6/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "ACE 2 protein" }, { "conditions": { "applied_force_pn": null, "buffer": "50mM Tris, 200mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [ "partner: Receptor Binding Domain" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 21.36 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 10.0 }, "construct": { "description": "Angiotensin converting Enzyme 2 with Receptor Binding Domain", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDXX6/", "evidence_id": "EV-SASBDB-SASDXX6", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "radius_of_gyration", "uncertainty": 0.562, "unit": "nm", "value": 6.709 }, "provenance": { "deposit_id": "SASDXX6", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDXX6/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "ACE2 RBD Complex" }, { "conditions": { "applied_force_pn": null, "buffer": "50mM Tris, 150mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [ "partner: Spike glycoprotein" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 11.42 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 10.0 }, "construct": { "description": "Angiotensin-converting enzyme 2 with Spike glycoprotein", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDYG7/", "evidence_id": "EV-SASBDB-SASDYG7", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "radius_of_gyration", "uncertainty": 0.896, "unit": "nm", "value": 4.393 }, "provenance": { "deposit_id": "SASDYG7", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDYG7/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "ACE 2 RBD with Umifenovir" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 769-805; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32132184", "evidence_id": "EV-DISPROT-DP02854r001", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 37 }, "provenance": { "deposit_id": "DP02854r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP02854" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP02854: disorder, residues 769-805" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-805", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/Q9BYF1", "evidence_id": "EV-AFDB-AF-Q9BYF1-F1", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 90.69 }, "provenance": { "deposit_id": "AF-Q9BYF1-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/Q9BYF1" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-Q9BYF1-F1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900002/overview", "evidence_id": "EV-MDDB-MCV1900002", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900002", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900002/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with FERR ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900004/overview", "evidence_id": "EV-MDDB-MCV1900004", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900004", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900004/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Human Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900013/overview", "evidence_id": "EV-MDDB-MCV1900013", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900013", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900013/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with Rhinolophus Affinis ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900014/overview", "evidence_id": "EV-MDDB-MCV1900014", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900014", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900014/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with FERR ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900015/overview", "evidence_id": "EV-MDDB-MCV1900015", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900015", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900015/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with MACR ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900016/overview", "evidence_id": "EV-MDDB-MCV1900016", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900016", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900016/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with Pangolin ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900017/overview", "evidence_id": "EV-MDDB-MCV1900017", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900017", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900017/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with PUS ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900018/overview", "evidence_id": "EV-MDDB-MCV1900018", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 196.94 }, "provenance": { "deposit_id": "MCV1900018", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900018/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with SIN1 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900019/overview", "evidence_id": "EV-MDDB-MCV1900019", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900019", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900019/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with SIN2 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900020/overview", "evidence_id": "EV-MDDB-MCV1900020", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900020", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900020/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with SIN3 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900021/overview", "evidence_id": "EV-MDDB-MCV1900021", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900021", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900021/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Bat-SARSr-CoV RATG13 spike receptor binding domain bound with ZIBB ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900022/overview", "evidence_id": "EV-MDDB-MCV1900022", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900022", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900022/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900023/overview", "evidence_id": "EV-MDDB-MCV1900023", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900023", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900023/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with MACR ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900024/overview", "evidence_id": "EV-MDDB-MCV1900024", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900024", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900024/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with Pangolin ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900025/overview", "evidence_id": "EV-MDDB-MCV1900025", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900025", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900025/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with PUS ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900026/overview", "evidence_id": "EV-MDDB-MCV1900026", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 199.56 }, "provenance": { "deposit_id": "MCV1900026", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900026/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with SIN1 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900027/overview", "evidence_id": "EV-MDDB-MCV1900027", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900027", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900027/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with SIN2 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900028/overview", "evidence_id": "EV-MDDB-MCV1900028", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900028", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900028/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with SIN3 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900029/overview", "evidence_id": "EV-MDDB-MCV1900029", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900029", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900029/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS spike receptor binding domain bound with ZIBB ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900030/overview", "evidence_id": "EV-MDDB-MCV1900030", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 192.05 }, "provenance": { "deposit_id": "MCV1900030", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900030/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with human ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900031/overview", "evidence_id": "EV-MDDB-MCV1900031", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 189.97 }, "provenance": { "deposit_id": "MCV1900031", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900031/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with FERR ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900032/overview", "evidence_id": "EV-MDDB-MCV1900032", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900032", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900032/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with MACR ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900033/overview", "evidence_id": "EV-MDDB-MCV1900033", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900033", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900033/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with Pangolin ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900034/overview", "evidence_id": "EV-MDDB-MCV1900034", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 190.9 }, "provenance": { "deposit_id": "MCV1900034", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900034/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with PUS ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900035/overview", "evidence_id": "EV-MDDB-MCV1900035", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 195.72 }, "provenance": { "deposit_id": "MCV1900035", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900035/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with SIN1 ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900036/overview", "evidence_id": "EV-MDDB-MCV1900036", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900036", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900036/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with SIN2 ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900037/overview", "evidence_id": "EV-MDDB-MCV1900037", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 195.56 }, "provenance": { "deposit_id": "MCV1900037", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900037/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with SIN3 ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900038/overview", "evidence_id": "EV-MDDB-MCV1900038", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 196.16 }, "provenance": { "deposit_id": "MCV1900038", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900038/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with ZIBB ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900039/overview", "evidence_id": "EV-MDDB-MCV1900039", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 178.97 }, "provenance": { "deposit_id": "MCV1900039", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900039/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with AFFINIS ACE2 (REAL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900040/overview", "evidence_id": "EV-MDDB-MCV1900040", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900040", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900040/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with human ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900041/overview", "evidence_id": "EV-MDDB-MCV1900041", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900041", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900041/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with FERR ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900042/overview", "evidence_id": "EV-MDDB-MCV1900042", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 198.55 }, "provenance": { "deposit_id": "MCV1900042", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900042/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with MACR ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900043/overview", "evidence_id": "EV-MDDB-MCV1900043", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900043", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900043/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with Pangolin ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900044/overview", "evidence_id": "EV-MDDB-MCV1900044", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900044", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900044/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with PUS ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900045/overview", "evidence_id": "EV-MDDB-MCV1900045", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900045", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900045/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with SIN1 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900046/overview", "evidence_id": "EV-MDDB-MCV1900046", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900046", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900046/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with SIN2 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900047/overview", "evidence_id": "EV-MDDB-MCV1900047", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900047", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900047/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with SIN3 ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900048/overview", "evidence_id": "EV-MDDB-MCV1900048", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900048", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900048/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SARS-CoV-2 spike receptor binding domain bound with ZIBB ACE2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900054/overview", "evidence_id": "EV-MDDB-MCV1900054", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900054", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900054/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "Human Angiotensin-converting enzyme 2 (ACE2), USA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900055/overview", "evidence_id": "EV-MDDB-MCV1900055", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900055", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900055/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "FERR Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900056/overview", "evidence_id": "EV-MDDB-MCV1900056", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900056", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900056/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MACR Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900057/overview", "evidence_id": "EV-MDDB-MCV1900057", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900057", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900057/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "PUS Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900058/overview", "evidence_id": "EV-MDDB-MCV1900058", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900058", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900058/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SIN1 Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900059/overview", "evidence_id": "EV-MDDB-MCV1900059", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900059", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900059/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SIN1 Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900060/overview", "evidence_id": "EV-MDDB-MCV1900060", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900060", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900060/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SIN2 Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900061/overview", "evidence_id": "EV-MDDB-MCV1900061", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900061", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900061/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "SIN3 Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; force field not stated", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900062/overview", "evidence_id": "EV-MDDB-MCV1900062", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 200.0 }, "provenance": { "deposit_id": "MCV1900062", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900062/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "ZIBB Angiotensin-converting enzyme 2 (ACE2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900065/overview", "evidence_id": "EV-MDDB-MCV1900065", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900065", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900065/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940402 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (aclidinium)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900066/overview", "evidence_id": "EV-MDDB-MCV1900066", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900066", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900066/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986449 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (afeletecan)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900067/overview", "evidence_id": "EV-MDDB-MCV1900067", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900067", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900067/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918588 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (amentoflavone)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900068/overview", "evidence_id": "EV-MDDB-MCV1900068", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900068", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900068/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10930330 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (azathioprine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900069/overview", "evidence_id": "EV-MDDB-MCV1900069", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900069", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900069/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986305 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (barusiban)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900070/overview", "evidence_id": "EV-MDDB-MCV1900070", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900070", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900070/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985913 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (bekanamycin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900071/overview", "evidence_id": "EV-MDDB-MCV1900071", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900071", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900071/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940311 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (bendamustine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900072/overview", "evidence_id": "EV-MDDB-MCV1900072", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900072", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900072/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986801 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (berzosertib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900073/overview", "evidence_id": "EV-MDDB-MCV1900073", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900073", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900073/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918574 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (birinapant)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900074/overview", "evidence_id": "EV-MDDB-MCV1900074", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900074", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900074/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10921548 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (brequinar)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900075/overview", "evidence_id": "EV-MDDB-MCV1900075", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900075", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900075/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986755 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (brigatinib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900076/overview", "evidence_id": "EV-MDDB-MCV1900076", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900076", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900076/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10930513 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (bromocriptine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900077/overview", "evidence_id": "EV-MDDB-MCV1900077", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900077", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900077/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10930315 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (brompheniramine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900078/overview", "evidence_id": "EV-MDDB-MCV1900078", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900078", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900078/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940945 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (bunazosin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900079/overview", "evidence_id": "EV-MDDB-MCV1900079", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900079", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900079/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986295 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (capreomycin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900080/overview", "evidence_id": "EV-MDDB-MCV1900080", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900080", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900080/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986707 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (ceritinib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900081/overview", "evidence_id": "EV-MDDB-MCV1900081", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900081", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900081/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-11040472 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (chloroquine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900082/overview", "evidence_id": "EV-MDDB-MCV1900082", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900082", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900082/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10941001 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (cimicoxib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900083/overview", "evidence_id": "EV-MDDB-MCV1900083", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900083", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900083/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918446 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (conivaptan)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900084/overview", "evidence_id": "EV-MDDB-MCV1900084", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900084", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900084/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985309 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (copanlisib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900085/overview", "evidence_id": "EV-MDDB-MCV1900085", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900085", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900085/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985767 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (dabigatran)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900086/overview", "evidence_id": "EV-MDDB-MCV1900086", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900086", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900086/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985081 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (dacomitinib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900087/overview", "evidence_id": "EV-MDDB-MCV1900087", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900087", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900087/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985418 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (dasatinib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900088/overview", "evidence_id": "EV-MDDB-MCV1900088", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900088", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900088/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940955 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (delavirdine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900089/overview", "evidence_id": "EV-MDDB-MCV1900089", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900089", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900089/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940322 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (desvenlafaxine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900090/overview", "evidence_id": "EV-MDDB-MCV1900090", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900090", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900090/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940392 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (deutivacaftor)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900091/overview", "evidence_id": "EV-MDDB-MCV1900091", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900091", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900091/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918477 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (dimenhydrinate)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900092/overview", "evidence_id": "EV-MDDB-MCV1900092", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900092", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900092/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10930274 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (disopyramide)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900093/overview", "evidence_id": "EV-MDDB-MCV1900093", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900093", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900093/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985120 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (doxazosin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900094/overview", "evidence_id": "EV-MDDB-MCV1900094", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900094", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900094/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10941126 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (doxazosin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900095/overview", "evidence_id": "EV-MDDB-MCV1900095", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900095", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900095/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986556 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (e7107)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900096/overview", "evidence_id": "EV-MDDB-MCV1900096", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900096", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900096/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986407 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (elamipretide)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900097/overview", "evidence_id": "EV-MDDB-MCV1900097", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900097", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900097/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986393 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (elbasvir)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900098/overview", "evidence_id": "EV-MDDB-MCV1900098", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900098", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900098/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918481 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (eletriptan)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900099/overview", "evidence_id": "EV-MDDB-MCV1900099", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900099", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900099/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940915 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (elvitegravir)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900100/overview", "evidence_id": "EV-MDDB-MCV1900100", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900100", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900100/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940388 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (fluoxetine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900101/overview", "evidence_id": "EV-MDDB-MCV1900101", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900101", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900101/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10930296 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (fluvastatin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900102/overview", "evidence_id": "EV-MDDB-MCV1900102", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900102", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900102/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918487 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (gemifloxacin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900103/overview", "evidence_id": "EV-MDDB-MCV1900103", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900103", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900103/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985758 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (gentamicin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900104/overview", "evidence_id": "EV-MDDB-MCV1900104", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900104", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900104/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985447 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (imatinib)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900105/overview", "evidence_id": "EV-MDDB-MCV1900105", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900105", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900105/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986447 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (ipamorelin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900106/overview", "evidence_id": "EV-MDDB-MCV1900106", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900106", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900106/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985229 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (kanamycin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900107/overview", "evidence_id": "EV-MDDB-MCV1900107", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900107", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900107/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985989 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (KPT-9274)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900108/overview", "evidence_id": "EV-MDDB-MCV1900108", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900108", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900108/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10940981 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (lixivaptan)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900109/overview", "evidence_id": "EV-MDDB-MCV1900109", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900109", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900109/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10930235 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (mefloquine)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900110/overview", "evidence_id": "EV-MDDB-MCV1900110", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900110", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900110/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918449 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (methylnaltrexone)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900111/overview", "evidence_id": "EV-MDDB-MCV1900111", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900111", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900111/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10930143 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (methylprednisolone)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900112/overview", "evidence_id": "EV-MDDB-MCV1900112", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900112", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900112/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918451 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (metronidazole)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900113/overview", "evidence_id": "EV-MDDB-MCV1900113", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900113", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900113/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918469 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (midazolam)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900114/overview", "evidence_id": "EV-MDDB-MCV1900114", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900114", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900114/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986091 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (modithromycin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900115/overview", "evidence_id": "EV-MDDB-MCV1900115", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900115", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900115/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10986538 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (nafithromycin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900116/overview", "evidence_id": "EV-MDDB-MCV1900116", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900116", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900116/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10985237 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (netilmicin)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "start 6VW1; Amber ff99SB-ILDN", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/MCV1900117/overview", "evidence_id": "EV-MDDB-MCV1900117", "mappings": [], "molecule_id": "Q9BYF1", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 2000.0 }, "provenance": { "deposit_id": "MCV1900117", "doi": null, "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/MCV1900117/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "DESRES-ANTON-10918458 2 µs simulation of an investigational or FDA approved drug molecule binding to the ectodomain of human ACE2, no water or ions (netupitant)" } ], "models": [], "molecule": { "components": [], "domains": [ { "end": 607, "name": "Peptidase M2", "start": 19 }, { "end": 805, "name": "Collectrin-like", "start": 614 } ], "gene": "ACE2", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "Q9BYF1" }, "ligands": [ "Zn(2+)", "chloride", "substrate" ], "modifications": [ { "kind": "ptm", "name": "Phosphotyrosine", "position": 781, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 783, "source": "UniProtKB" } ], "molecule_id": "Q9BYF1", "molecule_type": "protein", "name": "Angiotensin-converting enzyme 2", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "Q9BYF1", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BYF1/entry" }, "sequence": "MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF", "sequence_length": 805 }, "molecule_id": "Q9BYF1", "states": [], "transitions": [] }