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"https://www.rcsb.org/structure/2N3X", "evidence_id": "EV-PDB-2N3X-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2N3X", "doi": "10.1038/srep23928", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2N3X" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of TDP-43 Amyloidogenic Core Region" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR 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"temperature_c": 24.85 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2N4P", "evidence_id": "EV-PDB-2N4P-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2N4P", "doi": "10.1111/febs.13651", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2N4P" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the n-terminal domain of tdp-43" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "TAR DNA-BINDING PROTEIN 43 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4BS2", "evidence_id": "EV-PDB-4BS2-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "4BS2", "doi": "10.1038/NSMB.2698", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4BS2" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -163.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IUF", "evidence_id": "EV-PDB-4IUF-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.752 }, "provenance": { "deposit_id": "4IUF", "doi": "10.1093/nar/gkt1407", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IUF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -163.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4Y00", "evidence_id": "EV-PDB-4Y00-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "4Y00", "doi": "10.1038/srep21581", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4Y00" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -163.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4Y0F", "evidence_id": "EV-PDB-4Y0F-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.648 }, "provenance": { "deposit_id": "4Y0F", "doi": "10.1038/srep21581", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4Y0F" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Human TDP-43 RRM1 Domain in Complex with an Unmodified Single-stranded DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MDI", "evidence_id": "EV-PDB-5MDI-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "5MDI", "doi": "10.1038/s41467-017-00062-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MDI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.9, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MRG", "evidence_id": "EV-PDB-5MRG-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5MRG", "doi": "10.1074/jbc.M117.775965", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MRG" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of TDP-43 (residues 1-102)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5W50", "evidence_id": "EV-PDB-5W50-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "5W50", "doi": "10.1038/s41594-018-0045-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5W50" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5W52", "evidence_id": "EV-PDB-5W52-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "5W52", "doi": "10.1038/s41594-018-0045-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5W52" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains 0,1,2,3,4,5,6,7,8)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5W7V", "evidence_id": "EV-PDB-5W7V-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "5W7V", "doi": "10.1038/s41594-018-0045-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5W7V" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of the segment, DLIIKGISVHI, assembled into a triple-helical fibril" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Segment of TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5WHN", "evidence_id": "EV-PDB-5WHN-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.1 }, "provenance": { "deposit_id": "5WHN", "doi": "10.1038/s41594-018-0064-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5WHN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the segment, NFGAFS, from the low complexity domain of TDP-43, residues 312-317" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Segment of TAR DNA-binding protein 43 (chains 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"ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5WIA", "evidence_id": "EV-PDB-5WIA-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.002 }, "provenance": { "deposit_id": "5WIA", "doi": "10.1038/s41594-018-0064-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5WIA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43, residues 370-375" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5WIQ", "evidence_id": "EV-PDB-5WIQ-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.25 }, "provenance": { "deposit_id": "5WIQ", "doi": "10.1038/s41594-018-0064-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5WIQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43, residues 396-402" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5WKB", "evidence_id": "EV-PDB-5WKB-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.0 }, "provenance": { "deposit_id": "5WKB", "doi": "10.1038/s41594-018-0064-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5WKB" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5WKD", "evidence_id": "EV-PDB-5WKD-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "5WKD", "doi": "10.1038/s41594-018-0064-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5WKD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5X4F", "evidence_id": "EV-PDB-5X4F-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5X4F", "doi": "10.1038/s41598-017-06263-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5X4F" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of the N-terminal Domain of TDP-43" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "TAR DNA-binding protein 43, S48E Mutant (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6B1G", "evidence_id": "EV-PDB-6B1G-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6B1G", "doi": "10.15252/embj.201797452", "licence": "CC0 1.0 (wwPDB archive 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"10.15252/embj.201797452", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6B1G" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of TDP-43 N-terminal domain dimer." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "NFGTFS (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6CF4", "evidence_id": "EV-PDB-6CF4-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 0.75 }, "provenance": { "deposit_id": "6CF4", "doi": "10.1038/s41594-018-0064-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6CF4" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low complexity domain of TDP-43, residues 312-317" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6CFH", "evidence_id": "EV-PDB-6CFH-1", "mappings": [], "molecule_id": "Q13148", 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"evidence_id": "EV-PDB-6N37-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "6N37", "doi": "10.1038/s41594-019-0248-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N37" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SegA-sym, conformation of TDP-43 low complexity domain segment A sym" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N3A", "evidence_id": "EV-PDB-6N3A-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "6N3A", "doi": "10.1038/s41594-019-0248-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N3A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SegA-long, conformation of TDP-43 low complexity domain segment A long" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "segA long small (chains K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N3A", "evidence_id": "EV-PDB-6N3A-2", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "6N3A", "doi": "10.1038/s41594-019-0248-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N3A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SegA-long, conformation of TDP-43 low complexity domain segment A long" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N3B", "evidence_id": "EV-PDB-6N3B-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "6N3B", "doi": "10.1038/s41594-019-0248-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N3B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SegA-asym, conformation of TDP-43 low complexity domain segment A asym" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N3C", "evidence_id": "EV-PDB-6N3C-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "6N3C", "doi": "10.1038/s41594-019-0248-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N3C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SegB, conformation of TDP-43 low complexity domain segment A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,C,E,G,I)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6T4B", "evidence_id": "EV-PDB-6T4B-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.55 }, "provenance": { "deposit_id": "6T4B", "doi": "10.1016/j.isci.2020.101159", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6T4B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF HUMAN TDP-43 N-TERMINAL DOMAIN AT 2.55 A RESOLUTION" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform 2 of TAR DNA-binding protein 43 (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KWZ", "evidence_id": "EV-PDB-7KWZ-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7KWZ", "doi": "10.1038/s41467-021-21912-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KWZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "TDP-43 LCD amyloid fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7N9H", "evidence_id": "EV-PDB-7N9H-2", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "7N9H", "doi": "10.1016/j.celrep.2022.111007", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7N9H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the mammalian importin a1 bound to the 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"source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of TDP43 core peptide amyloid fiber" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 14.85 }, "construct": { "description": "TAR DNA-binding protein 43 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8A6I", "evidence_id": "EV-PDB-8A6I-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "8A6I", "doi": "10.1038/s41467-023-36023-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": 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"10.1038/s41586-023-06405-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8CG3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,U)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8CGG", "evidence_id": "EV-PDB-8CGG-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "8CGG", "doi": "10.1038/s41586-023-06405-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8CGG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,U)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8CGH", "evidence_id": "EV-PDB-8CGH-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.68 }, "provenance": { "deposit_id": "8CGH", "doi": "10.1038/s41586-023-06405-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8CGH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 3)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QX9", "evidence_id": "EV-PDB-8QX9-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.76 }, "provenance": { "deposit_id": "8QX9", "doi": "10.1038/s41467-023-44489-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QX9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "TDP-43 amyloid fibrils: Morphology-1a" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QXA", "evidence_id": "EV-PDB-8QXA-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.05 }, "provenance": { "deposit_id": "8QXA", "doi": "10.1038/s41467-023-44489-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QXA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "TDP-43 amyloid fibrils: Morphology-1b" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QXB", "evidence_id": "EV-PDB-8QXB-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.86 }, "provenance": { "deposit_id": "8QXB", "doi": "10.1038/s41467-023-44489-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QXB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "TDP-43 amyloid fibrils: Morphology-2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,C,E,G,I,q)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FOF", "evidence_id": "EV-PDB-9FOF-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "9FOF", "doi": "10.1101/2024.06.25.600403", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FOF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TAR DNA-binding protein 43 (chains A,C,E,G,o)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FOR", "evidence_id": "EV-PDB-9FOR-1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.75 }, "provenance": { "deposit_id": "9FOR", "doi": "10.1101/2024.06.25.600403", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FOR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.6, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=18765", "evidence_id": "EV-BMRB-18765", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr18765", "doi": "10.13018/BMR18765", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=18765" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone and side-chain assignments of 1H, 15N and 13C chemical shifts of RNA recognition motif 1 (RRM1) of TAR DNA-binding protein (TDP-43)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts, 31P chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=19290", "evidence_id": "EV-BMRB-19290", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr19290", "doi": "10.13018/BMR19290", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=19290" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.7, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 1H chemical shifts, 15N chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=19922", "evidence_id": "EV-BMRB-19922", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr19922", "doi": "10.13018/BMR19922", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=19922" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone 1H, 13C, and 15N Chemical Shift Assignments of human TDP-43 RRM2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 4.0, "salt_mM": null, "temperature_c": 39.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=25595", "evidence_id": "EV-BMRB-25595", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr25595", "doi": "10.13018/BMR25595", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=25595" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "NMR Structure of TDP-43 prion-like hydrophobic helix in DPC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=25659", "evidence_id": "EV-BMRB-25659", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr25659", "doi": "10.13018/BMR25659", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=25659" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution Structure of TDP-43 Amyloidogenic Core Region" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=25667", "evidence_id": "EV-BMRB-25667", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr25667", "doi": "10.13018/BMR25667", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=25667" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution Structure of the G335D Mutant of TDP-43 Amyloidogenic Core Region" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=25668", "evidence_id": "EV-BMRB-25668", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr25668", "doi": "10.13018/BMR25668", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=25668" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 3.8, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=25675", "evidence_id": "EV-BMRB-25675", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr25675", "doi": "10.13018/BMR25675", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=25675" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF TDP-43" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=30345", "evidence_id": "EV-BMRB-30345", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr30345", "doi": "10.13018/BMR30345", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=30345" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution structure of TDP-43 N-terminal domain dimer." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 3.9, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34081", "evidence_id": "EV-BMRB-34081", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34081", "doi": "10.13018/BMR34081", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34081" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution structure of TDP-43 (residues 1-102)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 14.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34737", "evidence_id": "EV-BMRB-34737", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34737", "doi": "10.13018/BMR34737", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34737" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure of the low complexity domain of TDP-43 (fragment 309-350) with methionine sulfoxide modifications" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=36060", "evidence_id": "EV-BMRB-36060", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr36060", "doi": "10.13018/BMR36060", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=36060" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution Structure of the N-terminal Domain of TDP-43" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 14.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=51494", "evidence_id": "EV-BMRB-51494", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr51494", "doi": "10.13018/BMR51494", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=51494" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone 1H, 13C, and 15N Chemical Shift Assignments for TDP-43 low complexity domain with methionine sulfoxide modifications" }, { "conditions": { "applied_force_pn": null, "buffer": "50 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 3% glycerol", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 4.29 nm.", "ph": 8.5, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "TAR DNA-binding protein 43", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDV74/", "evidence_id": "EV-SASBDB-SASDV74", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "radius_of_gyration", "uncertainty": 0.059, "unit": "nm", "value": 1.418 }, "provenance": { "deposit_id": "SASDV74", "doi": "10.1038/s42004-025-01522-1", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDV74/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Semi-synthesis of TDP-43 reveals the effects of phosphorylation in N-terminal domain on self-association" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES, 100 mM KCl, 2 mM TCEP", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16.5 nm.", "ph": 7.6, "salt_mM": null, "temperature_c": 25.0 }, "construct": { "description": "TAR DNA-binding protein 43", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDXL8/", "evidence_id": "EV-SASBDB-SASDXL8", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "radius_of_gyration", "uncertainty": 0.261, "unit": "nm", "value": 3.98 }, "provenance": { "deposit_id": "SASDXL8", "doi": "10.1038/s41467-026-68346-y", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDXL8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 266-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/29511089", "evidence_id": "EV-DISPROT-DP01108r001", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 149 }, "provenance": { "deposit_id": "DP01108r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01108" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP01108: disorder, residues 266-414" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 267-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/27545621", "evidence_id": "EV-DISPROT-DP01108r005", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 148 }, "provenance": { "deposit_id": "DP01108r005", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01108" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP01108: disorder, residues 267-414" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 263-414; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/26735904", "evidence_id": "EV-DISPROT-DP01108r013", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 152 }, "provenance": { "deposit_id": "DP01108r013", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01108" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP01108: disorder, residues 263-414" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 263-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/26735904", "evidence_id": "EV-DISPROT-DP01108r014", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 152 }, "provenance": { "deposit_id": "DP01108r014", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01108" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP01108: disorder, residues 263-414" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 263-414; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/26735904", "evidence_id": "EV-DISPROT-DP01108r020", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 152 }, "provenance": { "deposit_id": "DP01108r020", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01108" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP01108: disorder to order, residues 263-414" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 263-414; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/26735904", "evidence_id": "EV-DISPROT-DP01108r023", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 152 }, "provenance": { "deposit_id": "DP01108r023", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01108" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP01108: disorder to order, residues 263-414" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-414", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/Q13148", "evidence_id": "EV-AFDB-AF-Q13148-F1", "mappings": [], "molecule_id": "Q13148", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 65.19 }, "provenance": { "deposit_id": "AF-Q13148-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/Q13148" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-Q13148-F1" } ], "models": [], "molecule": { "components": [], "domains": [ { "end": 200, "name": "RRM 1", "start": 104 }, { "end": 262, "name": "RRM 2", "start": 191 } ], "gene": "TARDBP", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "Q13148" }, "ligands": [], "modifications": [ { "kind": "ptm", "name": "Phosphoserine", "position": 183, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 292, "source": "UniProtKB" }, { "kind": "ptm", "name": "Omega-N-methylarginine", "position": 293, "source": "UniProtKB" } ], "molecule_id": "Q13148", "molecule_type": "protein", "name": "TAR DNA-binding protein 43", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "Q13148", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q13148/entry" }, "sequence": "MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM", "sequence_length": 414 }, "molecule_id": "Q13148", "states": [], "transitions": [] }