{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "nmr_shifts", "force_spectroscopy", "integrative", "af_prediction" ], "unmapped_evidence": 57 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1MP8", "evidence_id": "EV-PDB-1MP8-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "1MP8", "doi": "10.1016/S0969-2126(02)00907-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1MP8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Focal Adhesion Kinase (FAK)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "4KA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4KAB", "evidence_id": "EV-PDB-4KAB-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.71 }, "provenance": { "deposit_id": "4KAB", "doi": "10.1016/j.bmcl.2013.07.050", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4KAB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 3-Methyl-1,4-dihydro-pyrazolo[4,5-c]pyrazole" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "H82" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6I8Z", "evidence_id": "EV-PDB-6I8Z-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.99 }, "provenance": { "deposit_id": "6I8Z", "doi": "10.1021/acs.jmedchem.8b01826", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6I8Z" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of PTK2 in complex with BI-4464." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 10.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose/maltodextrin-binding periplasmic protein,Focal adhesion kinase 1 (chains A,B,X,Y)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6LES", "evidence_id": "EV-PDB-6LES-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.004 }, "provenance": { "deposit_id": "6LES", "doi": "10.1038/s41598-019-56718-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6LES" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "3D domain-swapped dimer of the maltose-binding protein fused to a fragment of the focal adhesion kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P9K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YR9", "evidence_id": "EV-PDB-6YR9-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.925 }, "provenance": { "deposit_id": "6YR9", "doi": "10.1016/j.chembiol.2021.01.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YR9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PVT", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YVS", "evidence_id": "EV-PDB-6YVS-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.81 }, "provenance": { "deposit_id": "6YVS", "doi": "10.1016/j.chembiol.2021.01.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YVS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 5-{4-[(Pyridin-3-ylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3-dihydro-indol-2-one" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P1E", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YVY", "evidence_id": "EV-PDB-6YVY-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.918 }, "provenance": { "deposit_id": "6YVY", "doi": "10.1016/j.chembiol.2021.01.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YVY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "Q2H", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YXV", "evidence_id": "EV-PDB-6YXV-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.298 }, "provenance": { "deposit_id": "6YXV", "doi": "10.1016/j.chembiol.2021.01.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YXV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-{3-[(2-phenylamino-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl]-pyridin-2-yl}-methanesulfonamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "7QB", "CA", "EDO", "PEG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains DDD)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7PI4", "evidence_id": "EV-PDB-7PI4-4", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.24 }, "provenance": { "deposit_id": "7PI4", "doi": "10.1002/anie.202109237", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7PI4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1JNJ", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SDI", "evidence_id": "EV-PDB-9SDI-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.53 }, "provenance": { "deposit_id": "9SDI", "doi": "10.1038/s42004-025-01787-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SDI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-(1H-Pyrazol-4-yl)-nicotinic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A8R", "evidence_id": "EV-PDB-9A8R-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A8R", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A8R" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Integrative structure of focal adhesion kinase 1 from NMR data" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Isoform 5 of Focal adhesion kinase 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W9U", "evidence_id": "EV-PDB-7W9U-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.163 }, "provenance": { "deposit_id": "7W9U", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W9U" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Zn bound human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Isoform 5 of Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W8I", "evidence_id": "EV-PDB-7W8I-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.943 }, "provenance": { "deposit_id": "7W8I", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W8I" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Zn bound human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Isoform 5 of Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W8B", "evidence_id": "EV-PDB-7W8B-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.093 }, "provenance": { "deposit_id": "7W8B", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W8B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Isoform 5 of Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7W7Z", "evidence_id": "EV-PDB-7W7Z-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.15 }, "provenance": { "deposit_id": "7W7Z", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7W7Z" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of human Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PKE", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YT6", "evidence_id": "EV-PDB-6YT6-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.537 }, "provenance": { "deposit_id": "6YT6", "doi": "10.1016/j.chembiol.2021.01.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YT6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA", "P7N", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YQ1", "evidence_id": "EV-PDB-6YQ1-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.784 }, "provenance": { "deposit_id": "6YQ1", "doi": "10.1016/j.chembiol.2021.01.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YQ1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P4N" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YOJ", "evidence_id": "EV-PDB-6YOJ-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.361 }, "provenance": { "deposit_id": "6YOJ", "doi": "10.1016/j.chembiol.2021.01.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YOJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PW8", "evidence_id": "EV-PDB-6PW8-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.95 }, "provenance": { "deposit_id": "6PW8", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PW8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (FAT) Domain of the Focal Adhesion Kinase (FAK)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "30G" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -73.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4Q9S", "evidence_id": "EV-PDB-4Q9S-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.07 }, "provenance": { "deposit_id": "4Q9S", "doi": "10.1021/jm500669m", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4Q9S" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of human Focal Adhesion Kinase (Fak) bound to Compound1 (3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4NY0", "evidence_id": "EV-PDB-4NY0-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "4NY0", "doi": "10.1002/embj.201386399", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4NY0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of FERM domain of human focal adhesion kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "KAO", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4KAO", "evidence_id": "EV-PDB-4KAO-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.39 }, "provenance": { "deposit_id": "4KAO", "doi": "10.1016/j.bmcl.2013.07.050", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4KAO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K9Y" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4K9Y", "evidence_id": "EV-PDB-4K9Y-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "4K9Y", "doi": "10.1016/j.bmcl.2013.07.050", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4K9Y" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE Catalytic domain in complex with 1-[4-(6-Amino-purin-9-yl)-phenyl]-3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-urea" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K8A" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4K8A", "evidence_id": "EV-PDB-4K8A-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.91 }, "provenance": { "deposit_id": "4K8A", "doi": "10.1016/j.bmcl.2013.07.050", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4K8A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-based discovery of Focal Adhesion Kinase Inhibitors" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1BR", "IPA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4I4F", "evidence_id": "EV-PDB-4I4F-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "4I4F", "doi": "10.1016/j.bmcl.2013.01.047", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4I4F" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Focal Adhesion Kinase catalytic domain in complex with an allosteric binding pyrazolobenzothiazine compound." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1BQ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4I4E", "evidence_id": "EV-PDB-4I4E-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.55 }, "provenance": { "deposit_id": "4I4E", "doi": "10.1016/j.bmcl.2013.01.047", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4I4E" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "4GU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4GU9", "evidence_id": "EV-PDB-4GU9-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "4GU9", "doi": "10.1021/jm3016014", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4GU9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Focal adhesion kinase catalytic domain in complex with (2-Fluoro-phenyl)-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "10N" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4GU6", "evidence_id": "EV-PDB-4GU6-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.95 }, "provenance": { "deposit_id": "4GU6", "doi": "10.1021/jm3016014", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4GU6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-{3-[(5-Cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)- methyl]-pyridin-2-yl}-N-methyl-methanesulfonamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "0PF" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4EBW", "evidence_id": "EV-PDB-4EBW-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.65 }, "provenance": { "deposit_id": "4EBW", "doi": "10.1016/j.ejmech.2012.06.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4EBW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "0O7", "IPA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4EBV", "evidence_id": "EV-PDB-4EBV-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.67 }, "provenance": { "deposit_id": "4EBV", "doi": "10.1016/j.ejmech.2012.06.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4EBV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3S9O", "evidence_id": "EV-PDB-3S9O-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "3S9O", "doi": "10.1074/jbc.M114.593632", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3S9O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase showing N-terminal interactions in cis" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PXK", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "PTK2 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PXK", "evidence_id": "EV-PDB-3PXK-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.79 }, "provenance": { "deposit_id": "3PXK", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PXK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH Pyrrolo[2,3-d]thiazole" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "YAM" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3BZ3", "evidence_id": "EV-PDB-3BZ3-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "3BZ3", "doi": "10.1158/0008-5472.CAN-07-5155", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3BZ3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3B71", "evidence_id": "EV-PDB-3B71-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.82 }, "provenance": { "deposit_id": "3B71", "doi": "10.1016/j.jmb.2007.11.040", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3B71" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP", "ATP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -73.15 }, "construct": { "description": "Focal Adhesion Kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2IJM", "evidence_id": "EV-PDB-2IJM-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.187 }, "provenance": { "deposit_id": "2IJM", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2IJM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Focal Adhesion Kinase Domain with 2 molecules in the Asymmetric Unit Complexed with ADP and ATP" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "7PY" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -73.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2ETM", "evidence_id": "EV-PDB-2ETM-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "2ETM", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2ETM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Focal Adhesion Kinase Domain Complexed with 7H-Pyrrolo [2,3-d] pyrimidine Derivative" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1OW8", "evidence_id": "EV-PDB-1OW8-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "1OW8", "doi": "10.1016/j.str.2003.08.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1OW8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Paxillin LD2 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1OW7", "evidence_id": "EV-PDB-1OW7-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1OW7", "doi": "10.1016/j.str.2003.08.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1OW7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Focal adhesion kinase 1 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1OW6", "evidence_id": "EV-PDB-1OW6-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.35 }, "provenance": { "deposit_id": "1OW6", "doi": "10.1016/j.str.2003.08.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1OW6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FOCAL ADHESION KINASE 1 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1K05", "evidence_id": "EV-PDB-1K05-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "1K05", "doi": "10.1016/S0969-2126(02)00717-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1K05" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FOCAL ADHESION KINASE 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1K04", "evidence_id": "EV-PDB-1K04-1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.95 }, "provenance": { "deposit_id": "1K04", "doi": "10.1016/S0969-2126(02)00717-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1K04" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 8.0, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=28012", "evidence_id": "EV-BMRB-28012", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr28012", "doi": "10.13018/BMR28012", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=28012" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone resonance assignments for Human Focal Adhesion Targeting domain (892-1052)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 565-583; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/12467573", "evidence_id": "EV-DISPROT-DP03144r001", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 19 }, "provenance": { "deposit_id": "DP03144r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP03144" }, "reader": null, "source_kind": "literature", "technique": "xray", "title": "DisProt DP03144: disorder, residues 565-583" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-1052", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/Q05397", "evidence_id": "EV-AFDB-AF-Q05397-F1", "mappings": [], "molecule_id": "Q05397", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 74.5 }, "provenance": { "deposit_id": "AF-Q05397-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/Q05397" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-Q05397-F1" } ], "models": [], "molecule": { "components": [], "domains": [ { "end": 355, "name": "FERM", "start": 35 }, { "end": 680, "name": "Protein kinase", "start": 422 }, { "end": 1045, "name": "Focal AT", "start": 914 } ], "gene": "PTK2", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "Q05397" }, "ligands": [ "ATP" ], "modifications": [ { "kind": "ptm", "name": "N-acetylalanine", "position": 2, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 5, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 13, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 29, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 54, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine; by autocatalysis", "position": 397, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 407, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 570, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine; by RET and SRC", "position": 576, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine; by RET and SRC", "position": 577, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 580, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 722, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CDK5", "position": 732, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 843, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 861, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 887, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 910, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 914, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 925, "source": "UniProtKB" } ], "molecule_id": "Q05397", "molecule_type": "protein", "name": "Focal adhesion kinase 1", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "Q05397", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05397/entry" }, "sequence": "MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH", "sequence_length": 1052 }, "molecule_id": "Q05397", "states": [], "transitions": [] }