{
  "conflicts": [],
  "coverage": {
    "cells": {},
    "data_levels": {},
    "single_method_states": [],
    "states": [],
    "techniques": [
      "xray",
      "nmr_structure",
      "nmr_shifts",
      "force_spectroscopy",
      "af_prediction"
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    "unmapped_evidence": 34
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  "curation": {
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    "curator": "none",
    "file": "",
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        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "ADP",
          "ZN"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "BLOOM SYNDROME PROTEIN (chains A,B)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
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      "evidence_id": "EV-PDB-4CDG-1",
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        "unit": "Å",
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        "url": "https://www.rcsb.org/structure/4CDG"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "K",
          "PO4"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 8.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "BLM protein (chains H)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/5LUP",
      "evidence_id": "EV-PDB-5LUP-2",
      "mappings": [],
      "molecule_id": "P54132",
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        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
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      },
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        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/5LUP"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Structures of DHBN domain of human BLM helicase"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "K",
          "PO4"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 8.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
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        "labels": []
      },
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      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/5LUP",
      "evidence_id": "EV-PDB-5LUP-1",
      "mappings": [],
      "molecule_id": "P54132",
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        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.032
      },
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        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/5LUP"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Structures of DHBN domain of human BLM helicase"
    },
    {
      "conditions": {
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        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "IOD",
          "K"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 8.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Bloom syndrome protein (chains A,B,C,D)",
        "labels": []
      },
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      "data_level": "processed",
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      "mappings": [],
      "molecule_id": "P54132",
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        "uncertainty": null,
        "unit": "Å",
        "value": 2.16
      },
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        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/5MK5"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Structures of DHBN domain of human BLM helicase"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 5.4,
        "salt_mM": null,
        "temperature_c": 24.85
      },
      "construct": {
        "description": "Bloom Sydrome recQ helicase like protein (BLM) (chains L,M,N,O)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/5U6K",
      "evidence_id": "EV-PDB-5U6K-2",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.6
      },
      "provenance": {
        "deposit_id": "5U6K",
        "doi": "10.1016/j.str.2017.08.005",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/5U6K"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of TopBP1 BRCT4/5 in complex with a BLM phosphopeptide"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "ADP",
          "MG",
          "PG4",
          "RY8",
          "ZN"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 6.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Bloom syndrome protein,Bloom syndrome protein (chains A,B,C,D,E,F)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7AUD",
      "evidence_id": "EV-PDB-7AUD-1",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.96
      },
      "provenance": {
        "deposit_id": "7AUD",
        "doi": "10.7554/eLife.65339",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7AUD"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 4.6,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "fusion protein of Replication protein A 70 kDa DNA-binding subunit and Bloom syndrome protein (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7XUW",
      "evidence_id": "EV-PDB-7XUW-1",
      "mappings": [],
      "molecule_id": "P54132",
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        "uncertainty": null,
        "unit": "Å",
        "value": 1.8
      },
      "provenance": {
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        "doi": "10.7554/eLife.81639",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7XUW"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of RPA70N-BLMp2 fusion"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 5.6,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Bloom syndrome protein (chains B)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7XV0",
      "evidence_id": "EV-PDB-7XV0-2",
      "mappings": [],
      "molecule_id": "P54132",
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        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 1.5
      },
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        "doi": "10.7554/eLife.81639",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7XV0"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of RPA70N-BLMp1 fusion"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "CL"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "RecQ-like DNA helicase BLM,Microtubule-associated protein 1 light chain 3 beta (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/9P3E",
      "evidence_id": "EV-PDB-9P3E-1",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.0
      },
      "provenance": {
        "deposit_id": "9P3E",
        "doi": null,
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/9P3E"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "LC3B bound to BLM peptide"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "ACT",
          "ADP",
          "CA",
          "EDO",
          "GOL",
          "MG",
          "PG4",
          "ZN"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Bloom syndrome protein,Bloom syndrome protein (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7AUC",
      "evidence_id": "EV-PDB-7AUC-1",
      "mappings": [],
      "molecule_id": "P54132",
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        "uncertainty": null,
        "unit": "Å",
        "value": 1.53
      },
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        "doi": "10.7554/eLife.65339",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7AUC"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "ADP",
          "CA",
          "EDO",
          "ZN"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 6.0,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Bloom syndrome protein (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/4O3M",
      "evidence_id": "EV-PDB-4O3M-1",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.3
      },
      "provenance": {
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        "doi": "10.1107/S139900471400501X",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/4O3M"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Ternary complex of Bloom's syndrome helicase"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "ADP",
          "ZN"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "BLOOM'S SYNDROME HELICASE (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/4CGZ",
      "evidence_id": "EV-PDB-4CGZ-1",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 3.2
      },
      "provenance": {
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        "doi": "10.1093/NAR/GKV373",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/4CGZ"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "ACT",
          "ART"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 8.4,
        "salt_mM": null,
        "temperature_c": -183.15
      },
      "construct": {
        "description": "Bloom syndrome protein (chains A,B)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/3WE3",
      "evidence_id": "EV-PDB-3WE3-1",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.9
      },
      "provenance": {
        "deposit_id": "3WE3",
        "doi": "10.1038/srep03294",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/3WE3"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Structure of BLM RQC domain bound to an arsenate ion"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "ACT",
          "PO4"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 8.4,
        "salt_mM": null,
        "temperature_c": -183.15
      },
      "construct": {
        "description": "Bloom syndrome protein (chains A,B)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/3WE2",
      "evidence_id": "EV-PDB-3WE2-1",
      "mappings": [],
      "molecule_id": "P54132",
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        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.7
      },
      "provenance": {
        "deposit_id": "3WE2",
        "doi": "10.1038/srep03294",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/3WE2"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Structure of BLM RQC domain bound to a phosphate ion"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.5,
        "salt_mM": null,
        "temperature_c": 29.85
      },
      "construct": {
        "description": "HRDC domain from Bloom syndrome protein (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + NMR restraints",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/2RRD",
      "evidence_id": "EV-PDB-2RRD-1",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "structure",
        "uncertainty": null,
        "unit": null,
        "value": null
      },
      "provenance": {
        "deposit_id": "2RRD",
        "doi": "10.1093/jb/mvq097",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/2RRD"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "nmr_structure",
      "title": "Structure of HRDC domain from human Bloom syndrome protein, BLM"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.0,
        "salt_mM": null,
        "temperature_c": 26.85
      },
      "construct": {
        "description": "Bloom syndrome protein (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + NMR restraints",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/2MH9",
      "evidence_id": "EV-PDB-2MH9-1",
      "mappings": [],
      "molecule_id": "P54132",
      "observable": {
        "type": "structure",
        "uncertainty": null,
        "unit": null,
        "value": null
      },
      "provenance": {
        "deposit_id": "2MH9",
        "doi": "10.1007/s10858-014-9812-8",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/2MH9"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "nmr_structure",
      "title": "Resonance assignment of RQC domain of human Bloom syndrome protein"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.0,
        "salt_mM": null,
        "temperature_c": 24.85
      },
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        "labels": []
      },
      "data_format": "mmCIF + NMR restraints",
      "data_level": "processed",
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        "unit": null,
        "value": null
      },
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        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/2KV2"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "nmr_structure",
      "title": "Solution Structure of the human BLM HRDC domain"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "From the first sample condition list of the entry.",
        "ph": 7.5,
        "salt_mM": null,
        "temperature_c": 29.85
      },
      "construct": {
        "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts",
        "labels": []
      },
      "data_format": "NMR-STAR",
      "data_level": "processed",
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    {
      "conditions": {
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        "buffer": null,
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        "ions": [],
        "ligands": [],
        "notes": "From the first sample condition list of the entry.",
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        "temperature_c": 24.85
      },
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    {
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        "end": 851,
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        "start": 676
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        "end": 1024,
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      "Zn(2+)"
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        "position": 338,
        "source": "UniProtKB"
      },
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        "position": 358,
        "source": "UniProtKB"
      },
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        "position": 419,
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      },
      {
        "kind": "ptm",
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        "position": 1310,
        "source": "UniProtKB"
      }
    ],
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    "name": "RecQ-like DNA helicase BLM",
    "organism": {
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      "taxon_id": 9606
    },
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      "doi": null,
      "licence": "CC BY 4.0 (UniProt)",
      "retrieved": "2026-10-19",
      "source": "UniProtKB",
      "url": "https://www.uniprot.org/uniprotkb/P54132/entry"
    },
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    "sequence_length": 1417
  },
  "molecule_id": "P54132",
  "states": [],
  "transitions": []
}
