{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "saxs_sans", "epr_deer", "cd", "ensemble_fret", "force_spectroscopy", "auc" ], "unmapped_evidence": 78 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LD0", "evidence_id": "EV-PDB-2LD0-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LD0", "doi": "10.1016/j.bpj.2013.06.030", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LD0" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the N-terminal domain of huntingtin (htt17) in 50 % TFE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LD2", "evidence_id": "EV-PDB-2LD2-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LD2", "doi": "10.1016/j.bpj.2013.06.030", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LD2" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the N-terminal domain of huntingtin (htt17) in presence of DPC micelles" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin fusion protein (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IO4", "evidence_id": "EV-PDB-3IO4-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.63 }, "provenance": { "deposit_id": "3IO4", "doi": "10.1016/j.str.2009.08.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IO4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Huntingtin amino-terminal region with 17 Gln residues - Crystal C90" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IOT", "evidence_id": "EV-PDB-3IOT-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "3IOT", "doi": "10.1016/j.str.2009.08.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IOT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Huntingtin amino-terminal region with 17 Gln residues - crystal C92-b" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IOV", "evidence_id": "EV-PDB-3IOV-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "3IOV", "doi": "10.1016/j.str.2009.08.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IOV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Huntingtin amino-terminal region with 17 Gln residues - crystal C99" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4FEB", "evidence_id": "EV-PDB-4FEB-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "4FEB", "doi": "10.4161/pri.23807", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4FEB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4FEC", "evidence_id": "EV-PDB-4FEC-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "4FEC", "doi": "10.4161/pri.23807", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4FEC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Htt36Q3H" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Huntingtin (chains E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4RAV", "evidence_id": "EV-PDB-4RAV-3", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "4RAV", "doi": "10.1016/j.jmb.2015.03.021", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4RAV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1CYY" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YR6", "evidence_id": "EV-PDB-9YR6-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "9YR6", "doi": "10.1101/2025.11.21.689733v1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YR6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of HTTQ23-HAP40 complex bound to a small molecule ligand" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9PN0", "evidence_id": "EV-PDB-9PN0-4", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "9PN0", "doi": "10.1073/pnas.2520462123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9PN0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of HTTQ23-HAP40 complex bound to macrocycles HHD3, HD4 and HL2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9PMW", "evidence_id": "EV-PDB-9PMW-4", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "9PMW", "doi": "10.1073/pnas.2520462123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9PMW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of HTTQ23-HAP40 complex bound to macrocycles HHL1, HD4 and HL2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A,a)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8YAO", "evidence_id": "EV-PDB-8YAO-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 20.8 }, "provenance": { "deposit_id": "8YAO", "doi": "10.1126/sciadv.adw4124", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8YAO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-ET structure of huntingtin actin dimer complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8YAE", "evidence_id": "EV-PDB-8YAE-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 10.08 }, "provenance": { "deposit_id": "8YAE", "doi": "10.1126/sciadv.adw4124", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8YAE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-ET structure of huntingtin actin complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8W15", "evidence_id": "EV-PDB-8W15-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.72 }, "provenance": { "deposit_id": "8W15", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8W15" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "HTT in complex with HAP40 in the apo state." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1ACS" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8VLX", "evidence_id": "EV-PDB-8VLX-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "8VLX", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8VLX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "HTT in complex with HAP40 and a small molecule." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SAH", "evidence_id": "EV-PDB-8SAH-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8SAH", "doi": "10.1016/j.str.2023.06.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SAH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Huntingtin C-HEAT domain in complex with HAP40" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DXK", "evidence_id": "EV-PDB-7DXK-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.1 }, "provenance": { "deposit_id": "7DXK", "doi": "10.1016/j.str.2021.04.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DXK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human 128QHuntingtin-HAP40 complex structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DXJ", "evidence_id": "EV-PDB-7DXJ-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7DXJ", "doi": "10.1016/j.str.2021.04.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DXJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human 46QHuntingtin-HAP40 complex structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YEJ", "evidence_id": "EV-PDB-6YEJ-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 18.2 }, "provenance": { "deposit_id": "6YEJ", "doi": "10.1016/j.str.2020.06.008", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YEJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the Full-length disease type human Huntingtin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6X9O", "evidence_id": "EV-PDB-6X9O-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "6X9O", "doi": "10.1038/s42003-021-02895-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6X9O" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "High resolution cryoEM structure of huntingtin in complex with HAP40" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RMH", "evidence_id": "EV-PDB-6RMH-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 9.6 }, "provenance": { "deposit_id": "6RMH", "doi": "10.1016/j.str.2020.06.008", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RMH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The Rigid-body refined model of the normal Huntingtin." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "Huntingtin (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N8C", "evidence_id": "EV-PDB-6N8C-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6N8C", "doi": "10.1073/pnas.1821216116", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N8C" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Huntingtin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6EZ8", "evidence_id": "EV-PDB-6EZ8-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "6EZ8", "doi": "10.1038/nature25502", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6EZ8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human Huntingtin-HAP40 complex structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4FED", "evidence_id": "EV-PDB-4FED-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.807 }, "provenance": { "deposit_id": "4FED", "doi": "10.4161/pri.23807", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4FED" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Htt36Q3H" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4FE8", "evidence_id": "EV-PDB-4FE8-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "4FE8", "doi": "10.4161/pri.23807", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4FE8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Htt36Q3H-EX1-X1-C1(Alpha)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Huntingtin (chains B,D,F,H,J,L,N,P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3LRH", "evidence_id": "EV-PDB-3LRH-2", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "3LRH", "doi": "10.1016/j.jmb.2011.09.034", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3LRH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of anti-huntingtin VL domain in complex with huntingtin peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IOW", "evidence_id": "EV-PDB-3IOW-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "3IOW", "doi": "10.1016/j.str.2009.08.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IOW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Huntingtin amino-terminal region with 17 Gln residues - crystal C99-Hg" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding periplasmic protein,Huntingtin (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IOU", "evidence_id": "EV-PDB-3IOU-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "3IOU", "doi": "10.1016/j.str.2009.08.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IOU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Huntingtin amino-terminal region with 17 Gln residues - crystal C94" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Maltose-binding protein, huntingtin fusion protein (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IOR", "evidence_id": "EV-PDB-3IOR-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "3IOR", "doi": "10.1016/j.str.2009.08.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IOR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Huntingtin amino-terminal region with 17 Gln residues - crystal C95" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Maltose-binding periplasmic protein, HUNTINGTIN FUSION PROTEIN (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IO6", "evidence_id": "EV-PDB-3IO6-1", "mappings": [], "molecule_id": "P42858", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "3IO6", "doi": "10.1016/j.str.2009.08.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IO6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Huntingtin amino-terminal region with 17 Gln residues - crystal C92-a" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.2, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17642", "evidence_id": "EV-BMRB-17642", "mappings": [], "molecule_id": "P42858", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17642", "doi": "10.13018/BMR17642", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17642" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution structure of the N-terminal domain of huntingtin (htt17) in 50 % TFE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.0, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17644", "evidence_id": "EV-BMRB-17644", "mappings": [], "molecule_id": "P42858", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17644", "doi": "10.13018/BMR17644", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17644" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution structure of the N-terminal domain of huntingtin (htt17) in presence of DPC micelles" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=30545", "evidence_id": "EV-BMRB-30545", "mappings": [], "molecule_id": "P42858", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr30545", "doi": "10.13018/BMR30545", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=30545" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure of the Huttingtin tetramer/dimer mixture determined by paramagnetic NMR" }, { "conditions": { "applied_force_pn": null, "buffer": "20mM BisTris-HCl, 150mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16 nm.", "ph": 6.5, "salt_mM": null, "temperature_c": 10.0 }, "construct": { "description": "Huntingtin", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDQR8/", "evidence_id": "EV-SASBDB-SASDQR8", "mappings": [], "molecule_id": "P42858", "observable": { "type": "radius_of_gyration", "uncertainty": 0.019, "unit": "nm", "value": 3.299 }, "provenance": { "deposit_id": "SASDQR8", "doi": "10.1038/s41594-023-00920-0", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDQR8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity." }, { "conditions": { "applied_force_pn": null, "buffer": "20mM BisTris-HCl, 150mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample.", "ph": 6.5, "salt_mM": null, "temperature_c": 10.0 }, "construct": { "description": "Huntingtin", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDQS8/", "evidence_id": "EV-SASBDB-SASDQS8", "mappings": [], "molecule_id": "P42858", "observable": { "type": "radius_of_gyration", "uncertainty": 0.042, "unit": "nm", "value": 4.15 }, "provenance": { "deposit_id": "SASDQS8", "doi": "10.1038/s41594-023-00920-0", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDQS8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-17; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/19270701", "evidence_id": "EV-DISPROT-DP04129r001", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 17 }, "provenance": { "deposit_id": "DP04129r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP04129: disorder, residues 1-17" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-17; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/19270701", "evidence_id": "EV-DISPROT-DP04129r002", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 17 }, "provenance": { "deposit_id": "DP04129r002", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP04129: disorder, residues 1-17" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 19-29; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/19748341", "evidence_id": "EV-DISPROT-DP04129r003", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 11 }, "provenance": { "deposit_id": "DP04129r003", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "xray", "title": "DisProt DP04129: disorder, residues 19-29" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-34; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/28085263", "evidence_id": "EV-DISPROT-DP04129r004", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 34 }, "provenance": { "deposit_id": "DP04129r004", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP04129: disorder, residues 1-34" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-17; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/20026071", "evidence_id": "EV-DISPROT-DP04129r005", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 17 }, "provenance": { "deposit_id": "DP04129r005", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP04129: disorder, residues 1-17" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 39-88; evidence: fluorescence resonance energy transfer evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/28937758", "evidence_id": "EV-DISPROT-DP04129r006", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 50 }, "provenance": { "deposit_id": "DP04129r006", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "ensemble_fret", "title": "DisProt DP04129: disorder, residues 39-88" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-38; evidence: fluorescence resonance energy transfer evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/28937758", "evidence_id": "EV-DISPROT-DP04129r007", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 38 }, "provenance": { "deposit_id": "DP04129r007", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "ensemble_fret", "title": "DisProt DP04129: disorder, residues 1-38" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-90; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/29627459", "evidence_id": "EV-DISPROT-DP04129r008", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 90 }, "provenance": { "deposit_id": "DP04129r008", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP04129: disorder, residues 1-90" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/25464275", "evidence_id": "EV-DISPROT-DP04129r010", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r010", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: analytical ultracentrifugation evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/12193654", "evidence_id": "EV-DISPROT-DP04129r011", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r011", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "auc", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/12193654", "evidence_id": "EV-DISPROT-DP04129r012", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r012", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: small-angle X-ray scattering evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/26047735", "evidence_id": "EV-DISPROT-DP04129r014", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r014", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "saxs_sans", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/30315108", "evidence_id": "EV-DISPROT-DP04129r015", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r015", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: site-directed spin-labelling electron paramagnetic resonance evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/30315108", "evidence_id": "EV-DISPROT-DP04129r016", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r016", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "epr_deer", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/30315108", "evidence_id": "EV-DISPROT-DP04129r017", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r017", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-88; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32402249", "evidence_id": "EV-DISPROT-DP04129r018", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 88 }, "provenance": { "deposit_id": "DP04129r018", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP04129: disorder, residues 1-88" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-88; evidence: small-angle X-ray scattering evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/36864173", "evidence_id": "EV-DISPROT-DP04129r019", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 88 }, "provenance": { "deposit_id": "DP04129r019", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "saxs_sans", "title": "DisProt DP04129: disorder, residues 1-88" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-88; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/36864173", "evidence_id": "EV-DISPROT-DP04129r020", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 88 }, "provenance": { "deposit_id": "DP04129r020", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP04129: disorder, residues 1-88" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-87; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/33096080", "evidence_id": "EV-DISPROT-DP04129r021", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 87 }, "provenance": { "deposit_id": "DP04129r021", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP04129: disorder, residues 1-87" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1718-1732; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r022", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 15 }, "provenance": { "deposit_id": "DP04129r022", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 1718-1732" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 2067-2095; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r024", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 29 }, "provenance": { "deposit_id": "DP04129r024", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 2067-2095" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 407-664; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r028", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 258 }, "provenance": { "deposit_id": "DP04129r028", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 407-664" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1162-1226; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r031", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 65 }, "provenance": { "deposit_id": "DP04129r031", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 1162-1226" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-94; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r032", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 94 }, "provenance": { "deposit_id": "DP04129r032", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 1-94" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1323-1351; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r033", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 29 }, "provenance": { "deposit_id": "DP04129r033", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 1323-1351" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1376-1422; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r034", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 47 }, "provenance": { "deposit_id": "DP04129r034", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 1376-1422" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1859-1885; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r035", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 27 }, "provenance": { "deposit_id": "DP04129r035", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 1859-1885" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 2329-2351; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r036", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 23 }, "provenance": { "deposit_id": "DP04129r036", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 2329-2351" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 2631-2664; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r037", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 34 }, "provenance": { "deposit_id": "DP04129r037", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 2631-2664" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 3103-3142; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r038", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 40 }, "provenance": { "deposit_id": "DP04129r038", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 3103-3142" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 327-346; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r041", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 20 }, "provenance": { "deposit_id": "DP04129r041", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 327-346" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 964-981; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r042", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 18 }, "provenance": { "deposit_id": "DP04129r042", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 964-981" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1107-1124; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r043", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 18 }, "provenance": { "deposit_id": "DP04129r043", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 1107-1124" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 2476-2494; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r044", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 19 }, "provenance": { "deposit_id": "DP04129r044", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 2476-2494" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 2930-2948; evidence: cryogenic electron microscopy-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/32668197", "evidence_id": "EV-DISPROT-DP04129r045", "mappings": [], "molecule_id": "P42858", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 19 }, "provenance": { "deposit_id": "DP04129r045", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP04129" }, "reader": null, "source_kind": "literature", "technique": "cryoem", "title": "DisProt DP04129: disorder, residues 2930-2948" } ], "models": [], "molecule": { "components": [], "domains": [], "gene": "HTT", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P42858" }, "ligands": [], "modifications": [ { "kind": "ptm", "name": "N6-acetyllysine", "position": 9, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 176, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 234, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 343, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 411, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 417, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 419, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 432, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 442, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 640, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 643, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CDK5", "position": 1179, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CDK5", "position": 1199, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1870, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1874, "source": "UniProtKB" } ], "molecule_id": "P42858", "molecule_type": "protein", "name": "Huntingtin", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P42858", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42858/entry" }, "sequence": "MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQENKPCRIKGDIGQSTDDDSAPLVHCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVPLDTTEYPEEQYVSDILNYIDHGDPQVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLTGNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSSSYSELGLQLIIDVLTLRNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAATKQEEVWPALGDRALVPMVEQLFSHLLKVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASVPLSPKKGSEASAASRQSDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQENDTSGWFDVLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFVTPNTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSFSPYLISCTVINRLRDGDSTSTLEEHSEGKQIKNLPEETFSRFLLQLVGILLEDIVTKQLKVEMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSDGCGGSFYTLDSLNLRARSMITTHPALVLLWCQILLLVNHTDYRWWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCENLSTPTMLKKTLQCLEGIHLSQSGAVLTLYVDRLLCTPFRVLARMVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQSSGLAQRHQRLYSLLDRFRLSTMQDSLSPSPPVSSHPLDGDGHVSLETVSPDKDWYVHLVKSQCWTRSDSALLEGAELVNRIPAEDMNAFMMNSEFNLSLLAPCLSLGMSEISGGQKSALFEAAREVTLARVSGTVQQLPAVHHVFQPELPAEPAAYWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKDIVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQLPGLWSVVSSTEFVTHACSLIYCVHFILEAVAVQPGEQLLSPERRTNTPKAISEEEEEVDPNTQNPKYITAACEMVAEMVESLQSVLALGHKRNSGVPAFLTPLLRNIIISLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGTAFPEIPVEFLQEKEVFKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEESPPEEDTERTQINVLAVQAITSLVLSAMTVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSIIRGIVEQEIQAMVSKRENIATHHLYQAWDPVPSLSPATTGALISHEKLLLQINPERELGSMSYKLGQVSIHSVWLGNSITPLREEEWDEEEEEEADAPAPSSPPTSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSSARRTPAILISEVVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDEILAQYLVPATCKAAAVLGMDKAVAEPVSRLLESTLRSSHLPSRVGALHGVLYVLECDLLDDTAKQLIPVISDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLIENYPLDVGPEFSASIIQMCGVMLSGSEESTPSIIYHCALRGLERLLLSEQLSRLDAESLVKLSVDRVNVHSPHRAMAALGLMLTCMYTGKEKVSPGRTSDPNPAAPDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDIMNKVIGEFLSNQQPYPQFMATVVYKVFQTLHSTGQSSMVRDWVMLSLSNFTQRAPVAMATWSLSCFFVSASTSPWVAAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEEELDRRAFQSVLEVVAAPGSPYHRLLTCLRNVHKVTTC", "sequence_length": 3142 }, "molecule_id": "P42858", "states": [], "transitions": [] }