{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "saxs_sans", "force_spectroscopy", "integrative", "af_prediction" ], "unmapped_evidence": 88 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.6, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "REPLICATION PROTEIN A (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1EWI", "evidence_id": "EV-PDB-1EWI-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1EWI", "doi": "10.1023/A:1008373009786", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1EWI" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HUMAN REPLICATION PROTEIN A: GLOBAL FOLD OF THE N-TERMINAL RPA-70 DOMAIN REVEALS A BASIC CLEFT AND FLEXIBLE C-TERMINAL LINKER" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "PROTEIN (REPLICATION PROTEIN A (RPA)) (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1JMC", "evidence_id": "EV-PDB-1JMC-2", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "1JMC", "doi": "10.1038/385176a0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1JMC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SINGLE STRANDED DNA-BINDING DOMAIN OF HUMAN REPLICATION PROTEIN A BOUND TO SINGLE STRANDED DNA, RPA70 SUBUNIT, RESIDUES 183-420" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1L1O", "evidence_id": "EV-PDB-1L1O-3", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "1L1O", "doi": "10.1093/emboj/21.7.1855", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1L1O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the human Replication Protein A (RPA) trimerization core" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.9, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2B3G", "evidence_id": "EV-PDB-2B3G-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2B3G", "doi": "10.1073/pnas.0504614102", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2B3G" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53N (fragment 33-60) bound to RPA70N" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1EJ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IJH", "evidence_id": "EV-PDB-4IJH-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.498 }, "provenance": { "deposit_id": "4IJH", "doi": "10.1021/ml400032y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IJH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1EK" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IJL", "evidence_id": "EV-PDB-4IJL-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "4IJL", "doi": "10.1021/ml400032y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IJL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IPC", "evidence_id": "EV-PDB-4IPC-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.22 }, "provenance": { "deposit_id": "4IPC", "doi": "10.1021/bi400542z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IPC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the N-terminal domain of RPA70, E7R mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IPD", "evidence_id": "EV-PDB-4IPD-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.51 }, "provenance": { "deposit_id": "4IPD", "doi": "10.1021/bi400542z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IPD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the N-terminal domain of RPA70, E100R mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IPG", "evidence_id": "EV-PDB-4IPG-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.58 }, "provenance": { "deposit_id": "4IPG", "doi": "10.1021/bi400542z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IPG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the N-terminal domain of RPA70, E7R, E100R mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1FJ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IPH", "evidence_id": "EV-PDB-4IPH-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.94 }, "provenance": { "deposit_id": "4IPH", "doi": "10.1021/bi400542z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IPH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of N-terminal domain of RPA70 in complex with VU079104 inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1DZ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LUO", "evidence_id": "EV-PDB-4LUO-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.54 }, "provenance": { "deposit_id": "4LUO", "doi": "10.1021/jm401333u", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LUO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1DZ", "1XS" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LUV", "evidence_id": "EV-PDB-4LUV-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "4LUV", "doi": "10.1021/jm401333u", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LUV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1XS" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LW1", "evidence_id": "EV-PDB-4LW1-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.631 }, "provenance": { "deposit_id": "4LW1", "doi": "10.1021/jm401333u", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LW1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1XU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LWC", "evidence_id": "EV-PDB-4LWC-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.61 }, "provenance": { "deposit_id": "4LWC", "doi": "10.1021/jm401333u", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LWC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "2P9" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4O0A", "evidence_id": "EV-PDB-4O0A-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.2 }, "provenance": { "deposit_id": "4O0A", "doi": "10.1021/jm401333u", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4O0A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3HS" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4R4C", "evidence_id": "EV-PDB-4R4C-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "4R4C", "doi": "10.1021/ml5003629", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4R4C" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)-2-chlorobenzamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3HV" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4R4I", "evidence_id": "EV-PDB-4R4I-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "4R4I", "doi": "10.1021/ml5003629", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4R4I" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of RPA70N in complex with 5-(4-((6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3HW" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4R4O", "evidence_id": "EV-PDB-4R4O-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.33 }, "provenance": { "deposit_id": "4R4O", "doi": "10.1021/ml5003629", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4R4O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamothioyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3J0" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4R4T", "evidence_id": "EV-PDB-4R4T-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.28 }, "provenance": { "deposit_id": "4R4T", "doi": "10.1021/ml5003629", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4R4T" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)phenylthioamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "5KR" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5E7N", "evidence_id": "EV-PDB-5E7N-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.21 }, "provenance": { "deposit_id": "5E7N", "doi": "10.1002/cmdc.201500479", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5E7N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of RPA70N in complex with VU0085636" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5EAY", "evidence_id": "EV-PDB-5EAY-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.55 }, "provenance": { "deposit_id": "5EAY", "doi": "10.7554/eLife.09832", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5EAY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a Dna2 peptide in complex with Rpa 70N" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5N85", "evidence_id": "EV-PDB-5N85-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "5N85", "doi": "10.1038/ncomms15222", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5N85" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of RPA70N in complex with PrimPol (fragment 514-525)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5N8A", "evidence_id": "EV-PDB-5N8A-2", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.28 }, "provenance": { "deposit_id": "5N8A", "doi": "10.1038/ncomms15222", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5N8A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of RPA70N in complex with PrimPol (fragment 480-560)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "fusion protein of Replication protein A 70 kDa DNA-binding subunit and Werner syndrome ATP-dependent helicase (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XUT", "evidence_id": "EV-PDB-7XUT-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "7XUT", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XUT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N-WRN fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XUV", "evidence_id": "EV-PDB-7XUV-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "7XUV", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XUV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N-RMI1 fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "fusion protein of Replication protein A 70 kDa DNA-binding subunit and Bloom syndrome protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XUW", "evidence_id": "EV-PDB-7XUW-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "7XUW", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XUW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N-BLMp2 fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XV0", "evidence_id": "EV-PDB-7XV0-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "7XV0", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XV0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N-BLMp1 fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XV1", "evidence_id": "EV-PDB-7XV1-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "7XV1", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XV1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N-HelB fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XV4", "evidence_id": "EV-PDB-7XV4-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "7XV4", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XV4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N-ATRIP fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JZV", "evidence_id": "EV-PDB-8JZV-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "8JZV", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JZV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "RPA70N-ETAA1 fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JZY", "evidence_id": "EV-PDB-8JZY-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "8JZY", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JZY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "RPA70N-RAD9 fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit, N-terminally processed (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8RK2", "evidence_id": "EV-PDB-8RK2-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8RK2", "doi": "10.1038/s41586-024-07347-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8RK2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human Replication protein A (RPA; trimeric core) - ssDNA complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Subunit A (chains A)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A03", "evidence_id": "EV-PDB-9A03-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A03", "doi": "10.1093/nar/gkz1231", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A03" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Integrative model of 3' Nucleotide excision repair complex of XPA-DBD and RPA70AB" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "RPA70 (chains A)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A1V", "evidence_id": "EV-PDB-9A1V-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A1V", "doi": "10.1073/pnas.2207408119", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A1V" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Integrative model of Nucleotide excision repair complex of XPA and RPA on 5' junction substrate" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "RPA70 (chains A)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A1Y", "evidence_id": "EV-PDB-9A1Y-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A1Y", "doi": "10.1073/pnas.2207408119", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A1Y" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Integrative model of Nucleotide excision repair complex of XPA and RPA on 3' junction substrate" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MG", "SF4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit, N-terminally processed (chains L)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A88", "evidence_id": "EV-PDB-9A88-12", "mappings": [], "molecule_id": "P27694", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A88", "doi": "10.1038/s41467-024-52860-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A88" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Structure of the pre-incision complex in nucleotide excision repair " }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9J1S", "evidence_id": "EV-PDB-9J1S-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.55 }, "provenance": { "deposit_id": "9J1S", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9J1S" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human replication protein A: RPA70 subunit N-terminal domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "DCP", "MG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9MJ5", "evidence_id": "EV-PDB-9MJ5-3", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "9MJ5", "doi": "10.1093/nar/gkaf799", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9MJ5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Catalytic domain of human DNA polymerase alpha in complex with DNA and RPA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SF4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9PD3", "evidence_id": "EV-PDB-9PD3-12", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9PD3", "doi": "10.1038/s41586-026-10122-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9PD3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "NER dual incision complex - DuIS" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SF4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9PD4", "evidence_id": "EV-PDB-9PD4-11", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "9PD4", "doi": "10.1038/s41586-026-10122-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9PD4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "NER dual incision complex - DuIM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MG", "SF4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit, N-terminally processed (chains L)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A89", "evidence_id": "EV-PDB-9A89-12", "mappings": [], "molecule_id": "P27694", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A89", "doi": "10.1038/s41467-024-52860-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A89" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Structure of the pre-incision complex in nucleotide excision repair with tilted XPG core" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Subunit A (chains A)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A04", "evidence_id": "EV-PDB-9A04-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A04", "doi": "10.1093/nar/gkz1231", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A04" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Integrative model of 5' Nucleotide excision repair complex of XPA-DBD and RPA70AB" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8K00", "evidence_id": "EV-PDB-8K00-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "8K00", "doi": "10.7554/eLife.81639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8K00" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "RPA70N-MRE11 fusion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3HZ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4R4Q", "evidence_id": "EV-PDB-4R4Q-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "4R4Q", "doi": "10.1021/ml5003629", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4R4Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4NB3", "evidence_id": "EV-PDB-4NB3-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "4NB3", "doi": "10.1021/jm401730y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4NB3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1XT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LUZ", "evidence_id": "EV-PDB-4LUZ-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "4LUZ", "doi": "10.1021/jm401333u", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LUZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2B29", "evidence_id": "EV-PDB-2B29-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2B29", "doi": "10.1073/pnas.0504614102", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2B29" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "N-terminal domain of the RPA70 subunit of human replication protein A." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBUNIT (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1FGU", "evidence_id": "EV-PDB-1FGU-1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "1FGU", "doi": "10.1093/emboj/20.3.612", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1FGU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SSDNA-BINDING DOMAIN OF THE LARGE SUBUNIT OF REPLICATION PROTEIN A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.2, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=5822", "evidence_id": "EV-BMRB-5822", "mappings": [], "molecule_id": "P27694", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr5822", "doi": "10.13018/BMR5822", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=5822" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "1H, 15N and 13C assignments of single-stranded DNA binding domains from the 70 kDa subunit of Human Replication Protein A" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 150 mM NaCl, 2% glycerol, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [ "partner: 3-prime Nucleotide Excision Repair Junction Model Substrate", "partner: DNA repair protein complementing XP-A cells" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 9.7 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit with DNA repair protein complementing XP-A cells, 3-prime Nucleotide Excision Repair Junction Model Substrate", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDH44/", "evidence_id": "EV-SASBDB-SASDH44", "mappings": [], "molecule_id": "P27694", "observable": { "type": "radius_of_gyration", "uncertainty": 0.05, "unit": "nm", "value": 3.138 }, "provenance": { "deposit_id": "SASDH44", "doi": "10.1093/nar/gkz1231", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDH44/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "A key interaction with RPA orients XPA in NER complexes." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 150 mM NaCl, 2% glycerol, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [ "partner: 5-prime Nucleotide Excision Repair Junction Model Substrate", "partner: DNA repair protein complementing XP-A cells" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 97 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit with DNA repair protein complementing XP-A cells, 5-prime Nucleotide Excision Repair Junction Model Substrate", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDH54/", "evidence_id": "EV-SASBDB-SASDH54", "mappings": [], "molecule_id": "P27694", "observable": { "type": "radius_of_gyration", "uncertainty": 0.01, "unit": "nm", "value": 2.947 }, "provenance": { "deposit_id": "SASDH54", "doi": "10.1093/nar/gkz1231", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDH54/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "A key interaction with RPA orients XPA in NER complexes." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris pH 8.0, 150 mM NaCl, 2% glycerol, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [ "partner: 5-prime ss-ds DNA junction NER model substrate", "partner: DNA repair protein complementing XP-A cells", "partner: Replication protein A 14 kDa subunit", "partner: Replication protein A 32 kDa subunit" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16.45 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit with Replication protein A 14 kDa subunit, DNA repair protein complementing XP-A cells, Replication protein A 32 kDa subunit, 5-prime ss-ds DNA junction NER model substrate", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDP24/", "evidence_id": "EV-SASBDB-SASDP24", "mappings": [], "molecule_id": "P27694", "observable": { "type": "radius_of_gyration", "uncertainty": 0.932, "unit": "nm", "value": 4.626 }, "provenance": { "deposit_id": "SASDP24", "doi": "10.1073/pnas.2207408119", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDP24/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris pH 8.0, 150 mM NaCl, 2% glycerol, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [ "partner: 3-prime ss-ds DNA junction NER model substrate", "partner: DNA repair protein complementing XP-A cells", "partner: Replication protein A 14 kDa subunit", "partner: Replication protein A 32 kDa subunit" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 14.65 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Replication protein A 70 kDa DNA-binding subunit with DNA repair protein complementing XP-A cells, Replication protein A 32 kDa subunit, Replication protein A 14 kDa subunit, 3-prime ss-ds DNA junction NER model substrate", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPZ3/", "evidence_id": "EV-SASBDB-SASDPZ3", "mappings": [], "molecule_id": "P27694", "observable": { "type": "radius_of_gyration", "uncertainty": 0.512, "unit": "nm", "value": 4.286 }, "provenance": { "deposit_id": "SASDPZ3", "doi": "10.1073/pnas.2207408119", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPZ3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 109-168; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/10526407", "evidence_id": "EV-DISPROT-DP00061r005", "mappings": [], "molecule_id": "P27694", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 60 }, "provenance": { "deposit_id": "DP00061r005", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP00061" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP00061: disorder, residues 109-168" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 105-180; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/17721672", "evidence_id": "EV-DISPROT-DP00061r007", "mappings": [], "molecule_id": "P27694", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 76 }, "provenance": { "deposit_id": "DP00061r007", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP00061" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP00061: disorder, residues 105-180" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-616", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/P27694", "evidence_id": "EV-AFDB-AF-P27694-F1", "mappings": [], "molecule_id": "P27694", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 83.81 }, "provenance": { "deposit_id": "AF-P27694-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/P27694" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-P27694-F1" } ], "models": [], "molecule": { "components": [], "domains": [], "gene": "RPA1", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P27694" }, "ligands": [], "modifications": [ { "kind": "ptm", "name": "N-acetylmethionine", "position": 1, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 163, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 167, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 180, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 191, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 259, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 384, "source": "UniProtKB" } ], "molecule_id": "P27694", "molecule_type": "protein", "name": "Replication protein A 70 kDa DNA-binding subunit", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P27694", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P27694/entry" }, "sequence": "MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM", "sequence_length": 616 }, "molecule_id": "P27694", "states": [], "transitions": [] }