{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "saxs_sans", "force_spectroscopy", "af_prediction" ], "unmapped_evidence": 62 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.7, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Filamin A (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2AAV", "evidence_id": "EV-PDB-2AAV-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2AAV", "doi": "10.1182/blood-2005-10-3964", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2AAV" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR structure of Filamin A domain 17" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FILAMIN A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BP3", "evidence_id": "EV-PDB-2BP3-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.32 }, "provenance": { "deposit_id": "2BP3", "doi": "10.1182/BLOOD-2005-10-3964", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BP3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Filamin A domain 17 and GPIb alpha cytoplasmic domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL", "GSH" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FILAMIN A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BRQ", "evidence_id": "EV-PDB-2BRQ-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "2BRQ", "doi": "10.1016/J.MOLCEL.2006.01.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BRQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "BR", "DIO", "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FILAMIN-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J3S", "evidence_id": "EV-PDB-2J3S-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "2J3S", "doi": "10.1038/SJ.EMBOJ.7601827", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J3S" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the human filamin A Ig domains 19 to 21" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FILAMIN-A (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2JF1", "evidence_id": "EV-PDB-2JF1-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "2JF1", "doi": "10.1182/BLOOD-2007-12-127795", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2JF1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K3T", "evidence_id": "EV-PDB-2K3T-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K3T", "doi": "10.1371/journal.pone.0004928", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K3T" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of IG-Like Domain 23 from Human Filamin A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K7P", "evidence_id": "EV-PDB-2K7P-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K7P", "doi": "10.1074/jbc.M109.019661", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K7P" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Filamin A Ig-like domains 16-17" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MTP", "evidence_id": "EV-PDB-2MTP-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MTP", "doi": "10.1038/nsmb.2999", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MTP" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "The structure of Filamin repeat 21 bound to integrin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FILAMIN-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2W0P", "evidence_id": "EV-PDB-2W0P-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2W0P", "doi": "10.1074/JBC.M802592200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2W0P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Filamin-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3CNK", "evidence_id": "EV-PDB-3CNK-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "3CNK", "doi": "10.1002/prot.22336", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3CNK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the dimerization domain of human filamin A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.8, "salt_mM": null, "temperature_c": -153.15 }, "construct": { "description": "Filamin-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HOC", "evidence_id": "EV-PDB-3HOC-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "3HOC", "doi": "10.1093/hmg/ddp442", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HOC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the actin-binding domain of human filamin A mutant E254K" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -153.15 }, "construct": { "description": "Filamin-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HOP", "evidence_id": "EV-PDB-3HOP-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "3HOP", "doi": "10.1093/hmg/ddp442", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HOP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the actin-binding domain of human filamin A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -153.15 }, "construct": { "description": "Filamin-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HOR", "evidence_id": "EV-PDB-3HOR-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "3HOR", "doi": "10.1093/hmg/ddp442", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HOR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the actin-binding domain of human filamin A (reduced)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "Filamin-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3RGH", "evidence_id": "EV-PDB-3RGH-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.44 }, "provenance": { "deposit_id": "3RGH", "doi": "10.1107/S1744309111024249", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3RGH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4M9P", "evidence_id": "EV-PDB-4M9P-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.72 }, "provenance": { "deposit_id": "4M9P", "doi": "10.1074/jbc.M113.537456", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4M9P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the human filamin A Ig-like domains 3-5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA", "PR", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Filamin-A (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4P3W", "evidence_id": "EV-PDB-4P3W-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "4P3W", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4P3W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "C-terminal peptide of Integrin beta-2,Filamin-A IG21 domain (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5XR1", "evidence_id": "EV-PDB-5XR1-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5XR1", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5XR1" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Filamin-A (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6D8C", "evidence_id": "EV-PDB-6D8C-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.54 }, "provenance": { "deposit_id": "6D8C", "doi": "10.1038/s41594-018-0128-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6D8C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6EW1", "evidence_id": "EV-PDB-6EW1-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3070081803 }, "provenance": { "deposit_id": "6EW1", "doi": "10.1016/j.str.2018.09.007", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6EW1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the Filamin A Ig-like domains 3-5 mutant P637Q" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SFT", "evidence_id": "EV-PDB-7SFT-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "7SFT", "doi": "10.1182/blood.2022018333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SFT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Filamin complex-2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Filamin-A (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9LWX", "evidence_id": "EV-PDB-9LWX-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.29 }, "provenance": { "deposit_id": "9LWX", "doi": "10.1016/j.jmb.2025.169262", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9LWX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the Filamin A repeat 21" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9LXG", "evidence_id": "EV-PDB-9LXG-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.46 }, "provenance": { "deposit_id": "9LXG", "doi": "10.1016/j.jmb.2025.169262", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9LXG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Filamin A repeat 21 in complex with LARP4 Ala269-Asn281 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Filamin-A/Integrin alpha-IIb light chain, form 2 chimera (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SC4", "evidence_id": "EV-PDB-7SC4-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "7SC4", "doi": "10.1182/blood.2022018333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SC4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "filamin complex-1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Filamin-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3ISW", "evidence_id": "EV-PDB-3ISW-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "3ISW", "doi": "10.1074/jbc.M109.080911", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3ISW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "FILAMIN-A (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2WFN", "evidence_id": "EV-PDB-2WFN-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "2WFN", "doi": "10.1107/S0907444909037330", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2WFN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Filamin A actin binding domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Filamin-A (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K7Q", "evidence_id": "EV-PDB-2K7Q-1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K7Q", "doi": "10.1074/jbc.M109.019661", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K7Q" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Filamin A Ig-like domains 18-19" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.0, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=27795", "evidence_id": "EV-BMRB-27795", "mappings": [], "molecule_id": "P21333", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr27795", "doi": "10.13018/BMR27795", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=27795" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "FLNa4-6" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=30958", "evidence_id": "EV-BMRB-30958", "mappings": [], "molecule_id": "P21333", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr30958", "doi": "10.13018/BMR30958", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=30958" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Filamin complex-2" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris 50 mM NaCl 10mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 8.16 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Human Filamin A Ig-like domains 20-21/migfilin peptide complex", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDAE8/", "evidence_id": "EV-SASBDB-SASDAE8", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": null, "unit": "nm", "value": 2.41 }, "provenance": { "deposit_id": "SASDAE8", "doi": "10.1371/journal.pone.0136969", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDAE8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris 50 mM NaCl 10mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 8.5 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Human Filamin A Ig-like domains 20-21", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDAF8/", "evidence_id": "EV-SASBDB-SASDAF8", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": null, "unit": "nm", "value": 2.43 }, "provenance": { "deposit_id": "SASDAF8", "doi": "10.1371/journal.pone.0136969", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDAF8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris 50 mM NaCl 10mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 8.2 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Human Filamin A Ig-like domains 20-21*/migfilin peptide complex", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDAG8/", "evidence_id": "EV-SASBDB-SASDAG8", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": null, "unit": "nm", "value": 2.35 }, "provenance": { "deposit_id": "SASDAG8", "doi": "10.1371/journal.pone.0136969", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDAG8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris 50 mM NaCl 10mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 6.8 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Human Filamin A Ig-like domains 20-21*", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDAH8/", "evidence_id": "EV-SASBDB-SASDAH8", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": null, "unit": "nm", "value": 1.9 }, "provenance": { "deposit_id": "SASDAH8", "doi": "10.1371/journal.pone.0136969", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDAH8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris 50 mM NaCl 10 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 6.2 nm.", "ph": null, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Human Filamin A Ig-like domains 16-17", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDB32/", "evidence_id": "EV-SASBDB-SASDB32", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": null, "unit": "nm", "value": 1.83 }, "provenance": { "deposit_id": "SASDB32", "doi": "10.1038/s41598-017-04441-x", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDB32/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris 50 mM NaCl 10 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 8.3 nm.", "ph": null, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Human Filamin A Ig-like domains 16-17*", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDB42/", "evidence_id": "EV-SASBDB-SASDB42", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": null, "unit": "nm", "value": 2.4 }, "provenance": { "deposit_id": "SASDB42", "doi": "10.1038/s41598-017-04441-x", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDB42/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 100 mM NaCl, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 7.4 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Filamin A Ig.like domains 3-5 P637Q mutant", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDEP7/", "evidence_id": "EV-SASBDB-SASDEP7", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": 0.1, "unit": "nm", "value": 2.21 }, "provenance": { "deposit_id": "SASDEP7", "doi": "10.1016/j.str.2018.09.007", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDEP7/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 100 mM NaCl, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 7.34 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Filamin A Ig-like domains 3-5", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDEQ7/", "evidence_id": "EV-SASBDB-SASDEQ7", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": 0.1, "unit": "nm", "value": 2.19 }, "provenance": { "deposit_id": "SASDEQ7", "doi": "10.1016/j.str.2018.09.007", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDEQ7/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 100 mM NaCl, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 9.5 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Filamin A Ig-like domains 4-6", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDFD3/", "evidence_id": "EV-SASBDB-SASDFD3", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": 0.03, "unit": "nm", "value": 2.73 }, "provenance": { "deposit_id": "SASDFD3", "doi": "10.1016/j.bpj.2019.08.032", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDFD3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 100 mM NaCl, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 15 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Filamin A Ig-like domains 4-6, V711D mutation", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDFE3/", "evidence_id": "EV-SASBDB-SASDFE3", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": 0.2, "unit": "nm", "value": 4.07 }, "provenance": { "deposit_id": "SASDFE3", "doi": "10.1016/j.bpj.2019.08.032", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDFE3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 100 mM NaCl, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 14.8 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Filamin A Ig-like domains 4-6, V711D mutation", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDFF3/", "evidence_id": "EV-SASBDB-SASDFF3", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": 0.14, "unit": "nm", "value": 3.95 }, "provenance": { "deposit_id": "SASDFF3", "doi": "10.1016/j.bpj.2019.08.032", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDFF3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 100 mM NaCl, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Filamin A Ig-like domains 4-6, H743P mutation", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDFG3/", "evidence_id": "EV-SASBDB-SASDFG3", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": 0.1, "unit": "nm", "value": 4.29 }, "provenance": { "deposit_id": "SASDFG3", "doi": "10.1016/j.bpj.2019.08.032", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDFG3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris, 100 mM NaCl, 1 mM DTT", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 15.3 nm.", "ph": 8.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Filamin A Ig-like domains 4-6, H743P mutation", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDFH3/", "evidence_id": "EV-SASBDB-SASDFH3", "mappings": [], "molecule_id": "P21333", "observable": { "type": "radius_of_gyration", "uncertainty": 0.1, "unit": "nm", "value": 3.99 }, "provenance": { "deposit_id": "SASDFH3", "doi": "10.1016/j.bpj.2019.08.032", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDFH3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Critical Structural Defects Explain Filamin A Mutations Causing Mitral Valve Dysplasia." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-36; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/19773341", "evidence_id": "EV-DISPROT-DP01950r001", "mappings": [], "molecule_id": "P21333", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 36 }, "provenance": { "deposit_id": "DP01950r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01950" }, "reader": null, "source_kind": "literature", "technique": "xray", "title": "DisProt DP01950: disorder, residues 1-36" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-2647", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/P21333", "evidence_id": "EV-AFDB-AF-P21333-F1", "mappings": [], "molecule_id": "P21333", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 76.56 }, "provenance": { "deposit_id": "AF-P21333-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/P21333" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-P21333-F1" } ], "models": [], "molecule": { "components": [], "domains": [ { "end": 149, "name": "Calponin-homology (CH) 1", "start": 43 }, { "end": 269, "name": "Calponin-homology (CH) 2", "start": 166 } ], "gene": "FLNA", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P21333" }, "ligands": [], "modifications": [ { "kind": "ptm", "name": "N-acetylserine", "position": 2, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 11, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 376, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 508, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 700, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 781, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 837, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 865, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 906, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 968, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1055, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 1071, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-succinyllysine; alternate", "position": 1071, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1081, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1084, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 1089, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1301, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1338, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 1372, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1459, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1533, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 1538, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1630, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1734, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1835, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 1967, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2053, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2128, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2152, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2158, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2163, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2180, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2284, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2327, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2329, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 2336, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2338, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2370, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2414, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2510, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2523, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 2526, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 2569, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-succinyllysine; alternate", "position": 2569, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 2575, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 2599, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 2607, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 2621, "source": "UniProtKB" } ], "molecule_id": "P21333", "molecule_type": "protein", "name": "Filamin-A", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P21333", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21333/entry" }, "sequence": "MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP", "sequence_length": 2647 }, "molecule_id": "P21333", "states": [], "transitions": [] }