{
  "conflicts": [],
  "coverage": {
    "cells": {},
    "data_levels": {},
    "single_method_states": [],
    "states": [],
    "techniques": [
      "xray",
      "cryoem",
      "nmr_structure",
      "nmr_shifts",
      "force_spectroscopy",
      "af_prediction"
    ],
    "unmapped_evidence": 37
  },
  "curation": {
    "as_of": "",
    "curator": "none",
    "file": "",
    "status": "uncurated"
  },
  "evidence": [
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "BR",
          "CL"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Ankyrin (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/1N11",
      "evidence_id": "EV-PDB-1N11-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.7
      },
      "provenance": {
        "deposit_id": "1N11",
        "doi": "10.1093/emboj/cdf651",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/1N11"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "D34 REGION OF HUMAN ANKYRIN-R AND LINKER"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.0,
        "salt_mM": null,
        "temperature_c": 24.85
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + NMR restraints",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/2YQF",
      "evidence_id": "EV-PDB-2YQF-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "structure",
        "uncertainty": null,
        "unit": null,
        "value": null
      },
      "provenance": {
        "deposit_id": "2YQF",
        "doi": null,
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/2YQF"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "nmr_structure",
      "title": "Solution structure of the death domain of Ankyrin-1"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "GOL"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 8.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/2YVI",
      "evidence_id": "EV-PDB-2YVI-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 1.92
      },
      "provenance": {
        "deposit_id": "2YVI",
        "doi": null,
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/2YVI"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of a death domain of human ankryn protein"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 6.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Ankyrin-1 (chains C,D)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/3KBT",
      "evidence_id": "EV-PDB-3KBT-2",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.75
      },
      "provenance": {
        "deposit_id": "3KBT",
        "doi": "10.1182/blood-2009-11-255604",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/3KBT"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (ZU5-ANK)"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "HG"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 6.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Ankyrin-1 (chains C,D)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/3KBU",
      "evidence_id": "EV-PDB-3KBU-2",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.75
      },
      "provenance": {
        "deposit_id": "3KBU",
        "doi": "10.1182/blood-2009-11-255604",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/3KBU"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (ZU5-ANK), EMTS derivative"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "EOH"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.0,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Ankyrin-1 (chains A,B,C)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/3UD1",
      "evidence_id": "EV-PDB-3UD1-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.0
      },
      "provenance": {
        "deposit_id": "3UD1",
        "doi": "10.1016/j.jmb.2012.01.041",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/3UD1"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of ZU5A-ZU5B domains of human erythrocyte ankyrin"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains G)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7TW3",
      "evidence_id": "EV-PDB-7TW3-3",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 4.4
      },
      "provenance": {
        "deposit_id": "7TW3",
        "doi": "10.1038/s41594-022-00779-7",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7TW3"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Cryo-EM structure of human ankyrin complex (B2P1A1) from red blood cell"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7UZU",
      "evidence_id": "EV-PDB-7UZU-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.3
      },
      "provenance": {
        "deposit_id": "7UZU",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7UZU"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Ankyrin-1 (N-terminal region of membrane binding domain, local refinement from consensus reconstruction; bound to N-terminal peptide from band 3)"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "AJP",
          "CLR",
          "NAG",
          "PIO",
          "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/8CS9",
      "evidence_id": "EV-PDB-8CS9-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.74
      },
      "provenance": {
        "deposit_id": "8CS9",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/8CS9"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Composite reconstruction of Class 1 of the erythrocyte ankyrin-1 complex"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/8CSL",
      "evidence_id": "EV-PDB-8CSL-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 25.0
      },
      "provenance": {
        "deposit_id": "8CSL",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/8CSL"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Sub-tomogram averaging of erythrocyte ankyrin-1 complex"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "AJP",
          "CLR",
          "NAG",
          "PIO"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/8CTE",
      "evidence_id": "EV-PDB-8CTE-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.9
      },
      "provenance": {
        "deposit_id": "8CTE",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/8CTE"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Class 2 of erythrocyte ankyrin-1 complex (Composite map)"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/8CSV",
      "evidence_id": "EV-PDB-8CSV-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.7
      },
      "provenance": {
        "deposit_id": "8CSV",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/8CSV"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Local refinement of Anykyrin-1 (N-terminal half of membrane binding domain) in Class 2 of erythrocyte ankyrin-1 complex"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains J)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7V0X",
      "evidence_id": "EV-PDB-7V0X-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 3.0
      },
      "provenance": {
        "deposit_id": "7V0X",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7V0X"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Local refinement of ankyrin-1 (C-terminal half), class 1 of erythrocyte ankyrin-1 complex"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "AJP",
          "CLR"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains J)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7V0S",
      "evidence_id": "EV-PDB-7V0S-3",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.5
      },
      "provenance": {
        "deposit_id": "7V0S",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7V0S"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Local refinement of RhAG/CE trimer, class 1 of erythrocyte ankyrin-1 complex"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains A)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7V0M",
      "evidence_id": "EV-PDB-7V0M-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.7
      },
      "provenance": {
        "deposit_id": "7V0M",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7V0M"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Local refinement of ankyrin-1 (N-terminal half), class 1 of erythrocyte ankyrin-1 complex"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "AJP",
          "CLR",
          "NAG",
          "PIO",
          "PLC"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains H)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7V0K",
      "evidence_id": "EV-PDB-7V0K-3",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.4
      },
      "provenance": {
        "deposit_id": "7V0K",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7V0K"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Consensus refinement of human erythrocyte ankyrin-1 complex (Composite map)"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "AJP",
          "CLR"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains J)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7UZQ",
      "evidence_id": "EV-PDB-7UZQ-3",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.17
      },
      "provenance": {
        "deposit_id": "7UZQ",
        "doi": "10.1038/s41594-022-00792-w",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7UZQ"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Local refinement of RhAG-RhCE-ANK1(AR1-5), from consensus refinement of all classes"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains G)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7TW6",
      "evidence_id": "EV-PDB-7TW6-3",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 5.6
      },
      "provenance": {
        "deposit_id": "7TW6",
        "doi": "10.1038/s41594-022-00779-7",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7TW6"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Cryo-EM structure of human ankyrin complex (B4P1A1) from red blood cell"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "Ankyrin-1 (chains G,H)",
        "labels": []
      },
      "data_format": "mmCIF + EMDB map",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/7TW5",
      "evidence_id": "EV-PDB-7TW5-3",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 5.7
      },
      "provenance": {
        "deposit_id": "7TW5",
        "doi": "10.1038/s41594-022-00779-7",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/7TW5"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "cryoem",
      "title": "Cryo-EM structure of human ankyrin complex (B2P1A2) from red blood cell"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "CL",
          "EOH",
          "NA"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 7.0,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Ankyrin-1 (chains A,B,C)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/3UD2",
      "evidence_id": "EV-PDB-3UD2-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.21
      },
      "provenance": {
        "deposit_id": "3UD2",
        "doi": "10.1016/j.jmb.2012.01.041",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/3UD2"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of Selenomethionine ZU5A-ZU5B protein domains of human erythrocyte ankyrin"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [
          "BR"
        ],
        "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.",
        "ph": 6.5,
        "salt_mM": null,
        "temperature_c": -173.15
      },
      "construct": {
        "description": "Ankyrin-1 (chains A,B,C,D)",
        "labels": []
      },
      "data_format": "mmCIF + structure factors",
      "data_level": "processed",
      "data_link": "https://www.rcsb.org/structure/3F59",
      "evidence_id": "EV-PDB-3F59-1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "resolution",
        "uncertainty": null,
        "unit": "Å",
        "value": 2.0
      },
      "provenance": {
        "deposit_id": "3F59",
        "doi": "10.1182/blood-2008-10-184358",
        "licence": "CC0 1.0 (wwPDB archive data)",
        "retrieved": "2026-10-19",
        "source": "RCSB PDB",
        "url": "https://www.rcsb.org/structure/3F59"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "xray",
      "title": "Crystal structure of ZU5-ANK, the spectrin binding region of human erythroid ankyrin"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_vitro",
        "ions": [],
        "ligands": [],
        "notes": "From the first sample condition list of the entry.",
        "ph": 7.0,
        "salt_mM": null,
        "temperature_c": 24.85
      },
      "construct": {
        "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts",
        "labels": []
      },
      "data_format": "NMR-STAR",
      "data_level": "processed",
      "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=11390",
      "evidence_id": "EV-BMRB-11390",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "chemical_shift",
        "uncertainty": null,
        "unit": null,
        "value": null
      },
      "provenance": {
        "deposit_id": "bmr11390",
        "doi": "10.13018/BMR11390",
        "licence": "CC0 1.0 (verify)",
        "retrieved": "2026-10-19",
        "source": "BMRB",
        "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=11390"
      },
      "reader": null,
      "source_kind": "deposit",
      "technique": "nmr_shifts",
      "title": "Solution structure of the death domain of Ankyrin-1"
    },
    {
      "conditions": {
        "applied_force_pn": null,
        "buffer": null,
        "environment": "in_silico",
        "ions": [],
        "ligands": [],
        "notes": "Computed prediction; no experimental conditions.",
        "ph": null,
        "salt_mM": null,
        "temperature_c": null
      },
      "construct": {
        "description": "AlphaFold Monomer v2.0 pipeline, residues 1-1881",
        "labels": []
      },
      "data_format": "mmCIF, PAE JSON",
      "data_level": "processed",
      "data_link": "https://alphafold.ebi.ac.uk/entry/P16157",
      "evidence_id": "EV-AFDB-AF-P16157-F1",
      "mappings": [],
      "molecule_id": "P16157",
      "observable": {
        "type": "plddt",
        "uncertainty": null,
        "unit": "pLDDT",
        "value": 69.75
      },
      "provenance": {
        "deposit_id": "AF-P16157-F1",
        "doi": null,
        "licence": "CC BY 4.0",
        "retrieved": "2026-10-19",
        "source": "AlphaFold DB",
        "url": "https://alphafold.ebi.ac.uk/entry/P16157"
      },
      "reader": null,
      "source_kind": "computed",
      "technique": "af_prediction",
      "title": "AlphaFold DB prediction AF-P16157-F1"
    }
  ],
  "models": [],
  "molecule": {
    "components": [],
    "domains": [
      {
        "end": 1068,
        "name": "ZU5 1",
        "start": 913
      },
      {
        "end": 1216,
        "name": "ZU5 2",
        "start": 1070
      },
      {
        "end": 1487,
        "name": "Death",
        "start": 1403
      }
    ],
    "gene": "ANK1",
    "identifiers": {
      "genbank": null,
      "isoform": null,
      "nakb": null,
      "pdb": [],
      "rfam": null,
      "rnacentral": null,
      "uniprot": "P16157"
    },
    "ligands": [],
    "modifications": [
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 105,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 233,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 429,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 431,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 464,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 629,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 662,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyaspartate; by HIF1AN; partial",
        "position": 695,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 728,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 759,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "(3S)-3-hydroxyasparagine; by HIF1AN; partial",
        "position": 761,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 781,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 817,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 834,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 856,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphothreonine",
        "position": 961,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphotyrosine",
        "position": 1073,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1082,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphothreonine",
        "position": 1378,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphothreonine",
        "position": 1380,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1390,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1392,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1396,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphothreonine",
        "position": 1400,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1428,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1486,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1523,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1533,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1617,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1666,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1671,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1686,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1690,
        "source": "UniProtKB"
      },
      {
        "kind": "ptm",
        "name": "Phosphoserine",
        "position": 1696,
        "source": "UniProtKB"
      }
    ],
    "molecule_id": "P16157",
    "molecule_type": "protein",
    "name": "Ankyrin-1",
    "organism": {
      "name": "Homo sapiens",
      "taxon_id": 9606
    },
    "provenance": {
      "deposit_id": "P16157",
      "doi": null,
      "licence": "CC BY 4.0 (UniProt)",
      "retrieved": "2026-10-19",
      "source": "UniProtKB",
      "url": "https://www.uniprot.org/uniprotkb/P16157/entry"
    },
    "sequence": "MPYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP",
    "sequence_length": 1881
  },
  "molecule_id": "P16157",
  "states": [],
  "transitions": []
}