{ "conflicts": [ { "conflict_id": "CF-tau-microtubule-radius_of_gyration-EV-SASBDB-SASDV56-EV-SASBDB-SASDV66", "evidence_ids": [ "EV-SASBDB-SASDV56", "EV-SASBDB-SASDV66" ], "observable_type": "radius_of_gyration", "reason": "differ by 0.24 nm, beyond combined uncertainty 0.0603", "state_id": "tau-microtubule", "uncertainties": [ 0.046, 0.039 ], "unit": "nm", "values": [ 3.34, 3.1 ] } ], "coverage": { "cells": { "tau-disordered": { "af_prediction": 0, "cd": 1, "cryoem": 0, "force_spectroscopy": 0, "ftir_raman": 1, "integrative": 0, "microed": 0, "nmr_shifts": 0, "nmr_structure": 0, "saxs_sans": 3, "xray": 0 }, "tau-filament": { "af_prediction": 0, "cd": 0, "cryoem": 2, "force_spectroscopy": 0, "ftir_raman": 0, "integrative": 0, "microed": 0, "nmr_shifts": 0, "nmr_structure": 0, "saxs_sans": 0, "xray": 1 }, "tau-microtubule": { "af_prediction": 0, "cd": 0, "cryoem": 232, "force_spectroscopy": 3, "ftir_raman": 0, "integrative": 0, "microed": 3, "nmr_shifts": 1, "nmr_structure": 8, "saxs_sans": 8, "xray": 36 } }, "data_levels": { "tau-disordered": { "cd": "reported", "ftir_raman": "reported", "saxs_sans": "reported" }, "tau-filament": { "cryoem": "processed", "xray": "processed" }, "tau-microtubule": { "cryoem": "processed", "force_spectroscopy": "reported", "microed": "processed", "nmr_shifts": "processed", "nmr_structure": "processed", "saxs_sans": "processed", "xray": "processed" } }, "single_method_states": [], "states": [ "tau-disordered", "tau-filament", "tau-microtubule" ], "techniques": [ "xray", "cryoem", "microed", "nmr_structure", "nmr_shifts", "saxs_sans", "cd", "ftir_raman", "force_spectroscopy", "integrative", "af_prediction" ], "unmapped_evidence": 75 }, "curation": { "as_of": "2026-10-19", "curator": "draft (unreviewed)", "file": "P10636.yaml", "status": "draft" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10IK", "evidence_id": "EV-PDB-10IK-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "10IK", "doi": "10.64898/2026.02.12.705620", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10IK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S305I Frontotemporal Lobar Degeneration (FTLD) type II tau filament" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10NQ", "evidence_id": "EV-PDB-10NQ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.61 }, "provenance": { "deposit_id": "10NQ", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10NQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "u-VT Ic tau filament from VT Case 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": 11.85 }, "construct": { "description": "MICROTUBULE-ASSOCIATED PROTEIN TAU (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1I8H", "evidence_id": "EV-PDB-1I8H-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1I8H", "doi": "10.1074/jbc.M010327200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1I8H" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION STRUCTURE OF PIN1 WW DOMAIN COMPLEXED WITH HUMAN TAU PHOSPHOTHREONINE PEPTIDE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/28LO", "evidence_id": "EV-PDB-28LO-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "28LO", "doi": "10.1007/s00401-026-03049-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/28LO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau filament with G272V mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "VQIVYK peptide corresponding to residues 306-311 in the tau protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2ON9", "evidence_id": "EV-PDB-2ON9-1", "mappings": [ { "confidence": "high", "justification": "Structure titled as a filament or fibril.", "rule": "tau-filament-title", "state_id": "tau-filament", "who": "rule:tau-filament-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.51 }, "provenance": { "deposit_id": "2ON9", "doi": "10.1038/nature05695", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2ON9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of an amyloid forming peptide VQIVYK from the repeat region of Tau" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/37VX", "evidence_id": "EV-PDB-37VX-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.78 }, "provenance": { "deposit_id": "37VX", "doi": "10.1016/j.bbrc.2026.154679", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/37VX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE Type I structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/37VY", "evidence_id": "EV-PDB-37VY-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.96 }, "provenance": { "deposit_id": "37VY", "doi": "10.1016/j.bbrc.2026.154679", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/37VY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE Type I-like structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA", "PGE", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4TQE", "evidence_id": "EV-PDB-4TQE-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "4TQE", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4TQE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of tau peptide in complex with Tau5 antibody Fab fragment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein (chains P,X,Z)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5DMG", "evidence_id": "EV-PDB-5DMG-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "5DMG", "doi": "10.1080/19420862.2015.1117720", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5DMG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,E,I)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MP1", "evidence_id": "EV-PDB-5MP1-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "5MP1", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MP1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 7.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O3L", "evidence_id": "EV-PDB-5O3L-1", "mappings": [ { "confidence": "high", "justification": "Paired helical filament, cryo-EM.", "rule": "curator_assignment", "state_id": "tau-filament", "who": "curator:draft (unreviewed)" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "5O3L", "doi": "10.1038/nature23002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O3L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Paired helical filament in Alzheimer's disease brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O3T", "evidence_id": "EV-PDB-5O3T-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "5O3T", "doi": "10.1038/nature23002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O3T" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Straight filament in Alzheimer's disease brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "phosphorylated tau peptide (chains C,F,J,N,Q,R)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5ZIA", "evidence_id": "EV-PDB-5ZIA-3", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.603 }, "provenance": { "deposit_id": "5ZIA", "doi": "10.1016/j.str.2018.08.012", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5ZIA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Peptide from Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5ZV3", "evidence_id": "EV-PDB-5ZV3-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.093 }, "provenance": { "deposit_id": "5ZV3", "doi": "10.1186/s40478-018-0543-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5ZV3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human anti-tau antibody CBTAU-28.1 in complex with its tau peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5V5C", "evidence_id": "EV-PDB-5V5C-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.25 }, "provenance": { "deposit_id": "5V5C", "doi": "10.1038/nchem.2889", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5V5C" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5V5B", "evidence_id": "EV-PDB-5V5B-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "5V5B", "doi": "10.1038/nchem.2889", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5V5B" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O3O", "evidence_id": "EV-PDB-5O3O-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "5O3O", "doi": "10.1038/nature23002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O3O" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Pronase-treated paired helical filament in Alzheimer's disease brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5NVB", "evidence_id": "EV-PDB-5NVB-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5NVB", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5NVB" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of Tau(254-268) bound to F-actin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5N5B", "evidence_id": "EV-PDB-5N5B-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5N5B", "doi": "10.1038/s41467-017-02230-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5N5B" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of Tau(292-319) bound to F-actin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5N5A", "evidence_id": "EV-PDB-5N5A-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5N5A", "doi": "10.1038/s41467-017-02230-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5N5A" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of Tau(254-290) bound to F-actin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains I,J,K)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MP5", "evidence_id": "EV-PDB-5MP5-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.31 }, "provenance": { "deposit_id": "5MP5", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MP5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MP3", "evidence_id": "EV-PDB-5MP3-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.75 }, "provenance": { "deposit_id": "5MP3", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MP3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PGE", "branched: alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MO3", "evidence_id": "EV-PDB-5MO3-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.69 }, "provenance": { "deposit_id": "5MO3", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MO3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 8.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "VQIVYK (chains Z)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5K7N", "evidence_id": "EV-PDB-5K7N-1", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.1 }, "provenance": { "deposit_id": "5K7N", "doi": "10.1038/nmeth.4178", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5K7N" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "MicroED structure of tau VQIVYK peptide at 1.1 A resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "modified Tau peptide (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5HF3", "evidence_id": "EV-PDB-5HF3-2", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "5HF3", "doi": "10.1002/anie.201507976", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5HF3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAU-PHOSPHOPEPTIDE (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5E2W", "evidence_id": "EV-PDB-5E2W-3", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "5E2W", "doi": "10.1002/prot.24988", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5E2W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Anti-TAU AT8 FAB with triply phosphorylated TAU peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TAU PHOSPHOPEPTIDE (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5E2V", "evidence_id": "EV-PDB-5E2V-3", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.64 }, "provenance": { "deposit_id": "5E2V", "doi": "10.1002/prot.24988", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5E2V" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Anti-TAU AT8 FAB with doubly phosphorylated TAU peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CL", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau - peptide pS324 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5BTV", "evidence_id": "EV-PDB-5BTV-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "5BTV", "doi": "10.1096/fj.14-265009", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5BTV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains F,G)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4Y5I", "evidence_id": "EV-PDB-4Y5I-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "4Y5I", "doi": "10.1002/anie.201507976", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4Y5I" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "49F" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4Y32", "evidence_id": "EV-PDB-4Y32-2", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "4Y32", "doi": "10.1002/anie.201507976", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4Y32" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4NP8", "evidence_id": "EV-PDB-4NP8-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.51 }, "provenance": { "deposit_id": "4NP8", "doi": "10.1038/nsmb.1643", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4NP8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -73.15 }, "construct": { "description": "phospho-peptide (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4GLR", "evidence_id": "EV-PDB-4GLR-1", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "4GLR", "doi": "10.1074/jbc.M112.415935", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4GLR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the anti-ptau Fab (pT231/pS235_1) in complex with phosphoepitope pT231/pS235" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CL", "GOL", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4FL5", "evidence_id": "EV-PDB-4FL5-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "4FL5", "doi": "10.1096/fj.14-265009", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4FL5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MPD", "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN) (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4E0O", "evidence_id": "EV-PDB-4E0O-1", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.82 }, "provenance": { "deposit_id": "4E0O", "doi": "10.1073/pnas.1218792109", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4E0O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form III)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MPD", "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN) (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4E0N", "evidence_id": "EV-PDB-4E0N-1", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "4E0N", "doi": "10.1073/pnas.1218792109", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4E0N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MPD", "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN) (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4E0M", "evidence_id": "EV-PDB-4E0M-1", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "4E0M", "doi": "10.1073/pnas.1218792109", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4E0M" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACY", "ORA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3OVL", "evidence_id": "EV-PDB-3OVL-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.81 }, "provenance": { "deposit_id": "3OVL", "doi": "10.1371/journal.pbio.1001080", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3OVL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of an amyloid forming peptide VQIVYK from the TAU protein in complex with orange G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MZ7", "evidence_id": "EV-PDB-2MZ7-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MZ7", "doi": "10.1002/anie.201501714", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MZ7" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of Tau(267-312) bound to Microtubules" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-C of Microtubule-associated protein tau (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/28LQ", "evidence_id": "EV-PDB-28LQ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "28LQ", "doi": "10.1007/s00401-026-03049-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/28LQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau filament with S320F mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-C of Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/28LP", "evidence_id": "EV-PDB-28LP-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "28LP", "doi": "10.1007/s00401-026-03049-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/28LP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau filament with delG389_I392 mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-C of Microtubule-associated protein tau (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/28LJ", "evidence_id": "EV-PDB-28LJ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "28LJ", "doi": "10.1007/s00401-026-03049-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/28LJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau filament with D252V mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/22JY", "evidence_id": "EV-PDB-22JY-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "22JY", "doi": "10.64898/2026.01.19.700132", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/22JY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "P301L/S320F human tau filaments from mouse brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10NT", "evidence_id": "EV-PDB-10NT-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.05 }, "provenance": { "deposit_id": "10NT", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10NT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "u-VT IV tau filament from VT Case 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10NR", "evidence_id": "EV-PDB-10NR-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.37 }, "provenance": { "deposit_id": "10NR", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10NR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "u-VT II tau filament from VT Case 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10NP", "evidence_id": "EV-PDB-10NP-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.51 }, "provenance": { "deposit_id": "10NP", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB 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"P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.96 }, "provenance": { "deposit_id": "10NO", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10NO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "u-VT Ia tau filament from VT Case 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10MS", "evidence_id": "EV-PDB-10MS-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.24 }, "provenance": { "deposit_id": "10MS", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10MS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VT IV tau filament from VT Case 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10MR", "evidence_id": "EV-PDB-10MR-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "10MR", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10MR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VT II tau filament from VT Case 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10LN", "evidence_id": "EV-PDB-10LN-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.92 }, "provenance": { "deposit_id": "10LN", "doi": "10.1038/s41594-026-01879-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10LN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VT Ia tau filament from VT Case 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10IJ", "evidence_id": "EV-PDB-10IJ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "10IJ", "doi": "10.64898/2026.02.12.705620", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10IJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "S305I Frontotemporal Lobar Degeneration (FTLD) type I tau filament" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains P,Q,R)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6BB4", "evidence_id": "EV-PDB-6BB4-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.099 }, "provenance": { "deposit_id": "6BB4", "doi": "10.1038/s41598-018-24276-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6BB4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GDP", "GTP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6CVN", "evidence_id": "EV-PDB-6CVN-3", "mappings": [ { "confidence": "high", "justification": "Synthetic tau (R2x4) bound to the microtubule, cryo-EM.", "rule": "curator_assignment", "state_id": "tau-microtubule", "who": "curator:draft (unreviewed)" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "6CVN", "doi": "10.1126/science.aat1780", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6CVN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Model of synthetic 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null, "source_kind": "deposit", "technique": "cryoem", "title": "Doublet Tau Fibril from Corticobasal Degeneration Human Brain Tissue" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Tau Phosphopeptide (Ac-SR(pT)PSLP(pT)PPTRE-OH) (chains E,F,P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6XLI", "evidence_id": "EV-PDB-6XLI-3", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "6XLI", "doi": "10.3233/JAD-200544", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6XLI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "ACETYLATED TAU PEPTIDE (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EYC", "evidence_id": "EV-PDB-7EYC-3", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.49 }, "provenance": { "deposit_id": "7EYC", "doi": "10.1172/JCI156537", 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"environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7MKH", "evidence_id": "EV-PDB-7MKH-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "7MKH", "doi": "10.1007/s00401-021-02336-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": 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"source_kind": "deposit", "technique": "cryoem", "title": "Conformation 2 of straight filament from primary age-related tauopathy brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7NRV", "evidence_id": "EV-PDB-7NRV-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", 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null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P65", "evidence_id": "EV-PDB-7P65-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "7P65", "doi": "10.1038/s41586-021-03911-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P65" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Progressive supranuclear palsy tau filament" }, { "conditions": { "applied_force_pn": null, "buffer": null, 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"environment": "in_vitro", "ions": [], "ligands": [ "GDP", "GTP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6CVJ", "evidence_id": "EV-PDB-6CVJ-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "6CVJ", "doi": "10.1126/science.aat1780", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": 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Microtubule-associated protein tau (chains O)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7PQP", "evidence_id": "EV-PDB-7PQP-3", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.1 }, "provenance": { "deposit_id": "7PQP", "doi": "10.1021/acscentsci.1c00585", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7PQP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "tau-microtubule structural ensemble based on CryoEM data" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], 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"conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKJ", "evidence_id": "EV-PDB-7QKJ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.26 }, "provenance": { "deposit_id": "7QKJ", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 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filaments with phosphoserine (47a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKZ", "evidence_id": "EV-PDB-7QKZ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.65 }, "provenance": { "deposit_id": "7QKZ", "doi": 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"applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YMN", "evidence_id": "EV-PDB-7YMN-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.46 }, "provenance": { "deposit_id": "7YMN", "doi": "10.1016/j.isci.2022.105645", "licence": "CC0 1.0 (wwPDB 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"buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SP1", "evidence_id": "EV-PDB-7SP1-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7SP1", "doi": "10.1073/pnas.2119952119", "licence": "CC0 1.0 (wwPDB archive 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"https://www.rcsb.org/structure/7QL4", "evidence_id": "EV-PDB-7QL4-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7QL4", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QL4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "in vitro assembled tau filaments with structures like Paired Helical Filaments from Alzheimer's Disease" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QL3", "evidence_id": "EV-PDB-7QL3-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.32 }, "provenance": { "deposit_id": "7QL3", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QL3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "in vitro assembled 266/297 - 391 tau filaments with NaCl (8b)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QL2", "evidence_id": "EV-PDB-7QL2-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "7QL2", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QL2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 244-391 tau filaments with Na2P2O7 (20a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKX", "evidence_id": "EV-PDB-7QKX-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.16 }, "provenance": { "deposit_id": "7QKX", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 266/297 - 391 tau filaments with MgSO4 and NaCl (15b)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKW", "evidence_id": "EV-PDB-7QKW-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.32 }, "provenance": { "deposit_id": "7QKW", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 266-391 S356D tau filaments with KCl (44a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKM", "evidence_id": "EV-PDB-7QKM-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.66 }, "provenance": { "deposit_id": "7QKM", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 266-391 S356D tau filaments with NaCl (45a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKL", "evidence_id": "EV-PDB-7QKL-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.07 }, "provenance": { "deposit_id": "7QKL", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 266/297 - 391 tau filaments with ZnCl2 (11a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKK", "evidence_id": "EV-PDB-7QKK-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7QKK", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 258-391 tau filaments with phosphoglycerate, 700 rpm (39a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKH", "evidence_id": "EV-PDB-7QKH-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.17 }, "provenance": { "deposit_id": "7QKH", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 258-391 tau filaments with sodium azide, (41a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKG", "evidence_id": "EV-PDB-7QKG-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.36 }, "provenance": { "deposit_id": "7QKG", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 258-391 tau filaments with phosphoglycerate, 700 rpm (39a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QKF", "evidence_id": "EV-PDB-7QKF-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "7QKF", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QKF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 266/297 - 391 tau filaments with CuCl2 (12a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QK6", "evidence_id": "EV-PDB-7QK6-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.27 }, "provenance": { "deposit_id": "7QK6", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QK6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 258-391 tau filaments with heparan sulfate, 700 rpm (40a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QK5", "evidence_id": "EV-PDB-7QK5-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.92 }, "provenance": { "deposit_id": "7QK5", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QK5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 266/297 - 391 tau filaments with KCl (10a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QK3", "evidence_id": "EV-PDB-7QK3-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.44 }, "provenance": { "deposit_id": "7QK3", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QK3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 258-391 tau filaments, 700 rpm (38a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QK1", "evidence_id": "EV-PDB-7QK1-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.03 }, "provenance": { "deposit_id": "7QK1", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QK1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 297-394 tau filaments in PBS (35d)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QJZ", "evidence_id": "EV-PDB-7QJZ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as 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A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QJY", "evidence_id": "EV-PDB-7QJY-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "7QJY", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QJY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 266/297 - 391 tau filaments with LiCl (9a)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7QJX", "evidence_id": "EV-PDB-7QJX-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.99 }, "provenance": { "deposit_id": "7QJX", "doi": "10.7554/eLife.76494", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7QJX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "In vitro assembled 297-394 tau filaments, 700 rpm (34b)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,I,J,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P6E", "evidence_id": "EV-PDB-7P6E-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7P6E", "doi": "10.1038/s41586-021-03911-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P6E" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Argyrophilic grain disease type 2 tau filament" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P6B", "evidence_id": "EV-PDB-7P6B-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "7P6B", "doi": "10.1038/s41586-021-03911-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P6B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OTG", "evidence_id": "EV-PDB-8OTG-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "8OTG", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OTG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE typeI tau filament from Kii ALS/PDC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OTJ", "evidence_id": "EV-PDB-8OTJ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8OTJ", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OTJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "PHF tau filament from Kii ALS/PDC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8W", "evidence_id": "EV-PDB-8Q8W-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "8Q8W", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8W" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA4 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8V", "evidence_id": "EV-PDB-8Q8V-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "8Q8V", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8V" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8U", "evidence_id": "EV-PDB-8Q8U-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8Q8U", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8U" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA1 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8S", "evidence_id": "EV-PDB-8Q8S-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.68 }, "provenance": { "deposit_id": "8Q8S", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8S" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-THF" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8R", "evidence_id": "EV-PDB-8Q8R-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "8Q8R", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8R" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-PHF" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8M", "evidence_id": "EV-PDB-8Q8M-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "8Q8M", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-PHF long crossover" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8L", "evidence_id": "EV-PDB-8Q8L-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8Q8L", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-LIA7 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8F", "evidence_id": "EV-PDB-8Q8F-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.93 }, "provenance": { "deposit_id": "8Q8F", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-LIA5 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8E", "evidence_id": "EV-PDB-8Q8E-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.81 }, "provenance": { "deposit_id": "8Q8E", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8E" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-LIA4 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8D", "evidence_id": "EV-PDB-8Q8D-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8Q8D", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8D" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-LIA6 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8C", "evidence_id": "EV-PDB-8Q8C-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.92 }, "provenance": { "deposit_id": "8Q8C", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA10 (intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q88", "evidence_id": "EV-PDB-8Q88-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "8Q88", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q88" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-LIA2 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q7T", "evidence_id": "EV-PDB-8Q7T-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8Q7T", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q7T" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA11" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q7P", "evidence_id": "EV-PDB-8Q7P-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.28 }, "provenance": { "deposit_id": "8Q7P", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q7P" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA8 (intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q7M", "evidence_id": "EV-PDB-8Q7M-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.26 }, "provenance": { "deposit_id": "8Q7M", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q7M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA7 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q7L", "evidence_id": "EV-PDB-8Q7L-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.82 }, "provenance": { "deposit_id": "8Q7L", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q7L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA6 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q7F", "evidence_id": "EV-PDB-8Q7F-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.72 }, "provenance": { "deposit_id": "8Q7F", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q7F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q2L", "evidence_id": "EV-PDB-8Q2L-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "8Q2L", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q2L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q2K", "evidence_id": "EV-PDB-8Q2K-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.88 }, "provenance": { "deposit_id": "8Q2K", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q2K" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q2J", "evidence_id": "EV-PDB-8Q2J-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.23 }, "provenance": { "deposit_id": "8Q2J", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q2J" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-MIA2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q27", "evidence_id": "EV-PDB-8Q27-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.02 }, "provenance": { "deposit_id": "8Q27", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q27" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau: AD-MIA1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8PPO", "evidence_id": "EV-PDB-8PPO-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "8PPO", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8PPO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "First Intermediate Amyloid (FIA) - Tau" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8PII", "evidence_id": "EV-PDB-8PII-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.35 }, "provenance": { "deposit_id": "8PII", "doi": "10.1016/j.jbc.2024.107163", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8PII" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "VHH Z70 mutant 3 in interaction with PHF6 Tau peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8P34", "evidence_id": "EV-PDB-8P34-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.61 }, "provenance": { "deposit_id": "8P34", "doi": "10.1007/s00401-023-02598-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8P34" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OTI", "evidence_id": "EV-PDB-8OTI-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8OTI", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OTI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE typeIII tau filament" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OTH", "evidence_id": "EV-PDB-8OTH-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8OTH", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OTH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "TypeII tau filament from Kii ALS/PDC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OTC", "evidence_id": "EV-PDB-8OTC-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8OTC", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OTC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE typeII tau filament from Guam ALS/PDC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OT9", "evidence_id": "EV-PDB-8OT9-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8OT9", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OT9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE typeIII tau filament from Guam ALS/PDC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OT6", "evidence_id": "EV-PDB-8OT6-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "8OT6", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OT6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE typeI tau filament from Guam ALS/PDC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ORG", "evidence_id": "EV-PDB-8ORG-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", 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"source_kind": "deposit", "technique": "xray", "title": "VHH Z70 mutant 20 in interaction with PHF6 Tau peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OI0", "evidence_id": "EV-PDB-8OI0-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", 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null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau, acetylated repeat 1 and 2 fragment (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,a,b,c,d,e,f,g,h,i,j,k,l,m,n,o,p,q,r,s,t,u,v,w,x)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8FNZ", "evidence_id": "EV-PDB-8FNZ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.88 }, "provenance": { "deposit_id": 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"labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8CAQ", "evidence_id": "EV-PDB-8CAQ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "8CAQ", "doi": "10.1186/s40478-023-01565-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8CAQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8Y", "evidence_id": "EV-PDB-8Q8Y-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.88 }, "provenance": { "deposit_id": "8Q8Y", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8Y" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA6 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9A", "evidence_id": "EV-PDB-8Q9A-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "8Q9A", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA11 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SEI", "evidence_id": "EV-PDB-8SEI-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8SEI", "doi": "10.1038/s41594-024-01252-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SEI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "SF Tau from Down Syndrome" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains 0,1,A,B,C,D,M,N,O,P,Y,Z)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9B4L", "evidence_id": "EV-PDB-9B4L-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9B4L", "doi": "10.1038/s41586-025-09244-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9B4L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Filament of Tau in complex with D-TLKIVWI, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BXR", "evidence_id": "EV-PDB-9BXR-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "9BXR", "doi": "10.1186/s40478-024-01806-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BXR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Straight Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BXQ", "evidence_id": "EV-PDB-9BXQ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9BXQ", "doi": "10.1186/s40478-024-01806-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BXQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Paired Helical Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BXO", "evidence_id": "EV-PDB-9BXO-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "9BXO", "doi": "10.1186/s40478-024-01806-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BXO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Straight Filament of tau amyloids found in Down Syndrome individuals" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BXI", "evidence_id": "EV-PDB-9BXI-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "9BXI", "doi": "10.1186/s40478-024-01806-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BXI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Paired Helical Filament of tau amyloids found in Down Syndrome individuals" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BBM", "evidence_id": "EV-PDB-9BBM-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "9BBM", "doi": "10.1016/j.jbc.2024.107326", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BBM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "PHF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BBL", "evidence_id": "EV-PDB-9BBL-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "9BBL", "doi": "10.1016/j.jbc.2024.107326", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BBL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "THF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9B4O", "evidence_id": "EV-PDB-9B4O-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "9B4O", "doi": "10.1038/s41586-025-09244-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9B4O" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Alzheimer's Tau Paired Helical Filaments, determined by CryoEM, before addition of D-peptide disaggregants" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9B4N", "evidence_id": "EV-PDB-9B4N-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "9B4N", "doi": "10.1038/s41586-025-09244-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9B4N" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Filament of Tau in complex with D-TLKIVWR, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9B4M", "evidence_id": "EV-PDB-9B4M-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9B4M", "doi": "10.1038/s41586-025-09244-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9B4M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Filament of Tau in complex with D-TLKIVWS, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "8VH", "NH2" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,C,E,G,I,K,M,O,Q,S,U,W,Y,a,c)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9B3C", "evidence_id": "EV-PDB-9B3C-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "9B3C", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9B3C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "type 2 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "8VH", "NH2" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,C,E,G,I,K,M,O,Q,S,U,W,Y,a,c)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9B3A", "evidence_id": "EV-PDB-9B3A-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "9B3A", "doi": "10.1038/s41557-025-01805-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9B3A" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "filament of type 1 KD-mxyl miniature tau macrocycle derived from 4R tauopathic fold" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1AHG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9AXZ", "evidence_id": "EV-PDB-9AXZ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9AXZ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9AXZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "geranine G-induced 2N4R tau filaments" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "tau protein (chains A)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZZX", "evidence_id": "EV-PDB-8ZZX-1", "mappings": [], "molecule_id": "P10636", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "8ZZX", "doi": "10.1016/j.str.2019.09.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ZZX" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Insight into the structure of the unstructured tau protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZX6", "evidence_id": "EV-PDB-8ZX6-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8ZX6", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ZX6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Heparin bound Tau fibril PHF" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZWM", "evidence_id": "EV-PDB-8ZWM-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8ZWM", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ZWM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Heparin bound Tau fibril polymorph 4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZWL", "evidence_id": "EV-PDB-8ZWL-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8ZWL", "doi": null, "licence": "CC0 1.0 (wwPDB archive 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temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UQ7", "evidence_id": "EV-PDB-8UQ7-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.31 }, "provenance": { "deposit_id": "8UQ7", "doi": "10.1038/s41467-024-52265-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UQ7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Alzheimer's 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"10.1073/pnas.2316175121", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8TTN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "PHF1-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S396E, S400E, T403E, S404E)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8TTL", "evidence_id": "EV-PDB-8TTL-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "8TTL", "doi": "10.1073/pnas.2316175121", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8TTL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "AT8-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S202E, T205E, S208E)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SEH", "evidence_id": "EV-PDB-8SEH-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8SEH", "doi": "10.1038/s41594-024-01252-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SEH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "PHF Tau from Down Syndrome" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8R3T", "evidence_id": "EV-PDB-8R3T-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8R3T", "doi": "10.1038/s41467-023-39314-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8R3T" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cofactor-free Tau 4R2N isoform" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QJJ", "evidence_id": "EV-PDB-8QJJ-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.35 }, "provenance": { "deposit_id": "8QJJ", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QJJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE type II (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QDV", "evidence_id": "EV-PDB-8QDV-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "8QDV", "doi": "10.1038/s42003-025-08548-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QDV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,C,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QCR", "evidence_id": "EV-PDB-8QCR-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.75 }, "provenance": { "deposit_id": "8QCR", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QCR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA12 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QCP", "evidence_id": "EV-PDB-8QCP-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.21 }, "provenance": { "deposit_id": "8QCP", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QCP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - AD-LIA8 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9O", "evidence_id": "EV-PDB-8Q9O-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8Q9O", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9O" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CTE tau intermediate amyloid (LIA-17)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9M", "evidence_id": "EV-PDB-8Q9M-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.65 }, "provenance": { "deposit_id": "8Q9M", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-type I (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9L", "evidence_id": "EV-PDB-8Q9L-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.76 }, "provenance": { "deposit_id": "8Q9L", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-LIA14 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9K", "evidence_id": "EV-PDB-8Q9K-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8Q9K", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9K" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-LIA13 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9J", "evidence_id": "EV-PDB-8Q9J-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.96 }, "provenance": { "deposit_id": "8Q9J", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9J" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-LIA7 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,C,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9I", "evidence_id": "EV-PDB-8Q9I-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.56 }, "provenance": { "deposit_id": "8Q9I", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9I" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-LIA6 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9H", "evidence_id": "EV-PDB-8Q9H-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.18 }, "provenance": { "deposit_id": "8Q9H", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9H" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-LIA4 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9G", "evidence_id": "EV-PDB-8Q9G-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.65 }, "provenance": { "deposit_id": "8Q9G", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9G" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-LIA5 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,c)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9F", "evidence_id": "EV-PDB-8Q9F-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.91 }, "provenance": { "deposit_id": "8Q9F", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-LIA3 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9E", "evidence_id": "EV-PDB-8Q9E-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.97 }, "provenance": { "deposit_id": "8Q9E", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9E" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA18 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9D", "evidence_id": "EV-PDB-8Q9D-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.16 }, "provenance": { "deposit_id": "8Q9D", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9D" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA15 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9C", "evidence_id": "EV-PDB-8Q9C-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8Q9C", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA14 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q9B", "evidence_id": "EV-PDB-8Q9B-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8Q9B", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q9B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA13 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q99", "evidence_id": "EV-PDB-8Q99-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8Q99", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q99" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA10 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q98", "evidence_id": "EV-PDB-8Q98-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "8Q98", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q98" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA8 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q97", "evidence_id": "EV-PDB-8Q97-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.99 }, "provenance": { "deposit_id": "8Q97", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q97" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA9 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q92", "evidence_id": "EV-PDB-8Q92-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.05 }, "provenance": { "deposit_id": "8Q92", "doi": "10.1186/s40478-023-01658-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q92" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8Z", "evidence_id": "EV-PDB-8Q8Z-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.16 }, "provenance": { "deposit_id": "8Q8Z", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA7 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-D of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Q8X", "evidence_id": "EV-PDB-8Q8X-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.54 }, "provenance": { "deposit_id": "8Q8X", "doi": "10.1038/s41586-023-06788-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Q8X" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Tau - CTE-MIA5 (tau intermediate amyloid)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CL", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9QNK", "evidence_id": "EV-PDB-9QNK-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "9QNK", "doi": "10.1039/d5dd00132c", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9QNK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Tau pT245 phosphopeptide binding to 14-3-3sigma" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9PVA", "evidence_id": "EV-PDB-9PVA-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "9PVA", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9PVA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "295-330 S320F tau" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + 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temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9OFW", "evidence_id": "EV-PDB-9OFW-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "9OFW", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9OFW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "328-363 tau mutant S341L_S352I" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O8H", "evidence_id": "EV-PDB-9O8H-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9O8H", "doi": "10.1016/j.isci.2026.115501", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O8H" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "amyloid fibril of recombinant full-length 2N4R tau complexed with mouse liver 18S ribosomal RNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O8E", "evidence_id": "EV-PDB-9O8E-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9O8E", "doi": "10.1016/j.isci.2026.115501", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O8E" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "amyloid fibril of recombinant full-length 2N4R tau complexed with unfractionated mouse liver RNA and seeded by Alzheimer's disease tau fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains S,T,U,V,W,i,j,k,l,m,n,o,p,q,r)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O7C", "evidence_id": "EV-PDB-9O7C-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.31 }, "provenance": { "deposit_id": "9O7C", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O7C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD THF incubated with DMSO (Flat Backbone E342)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains O,P,Q,R,S,W,X,Y,Z,a,d,e,f,g,h)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O7B", "evidence_id": "EV-PDB-9O7B-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.31 }, "provenance": { "deposit_id": "9O7B", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O7B" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD THF incubated with DMSO (Kinked Backbone E342)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains F,G,H,I,J,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O79", "evidence_id": "EV-PDB-9O79-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.55 }, "provenance": { "deposit_id": "9O79", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O79" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD PHF incubated with DMSO (Kinked Backbone E342)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1B91" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains O,P,Q,R,S,V,W,X,Y,Z,b,c,d,e,f)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O76", "evidence_id": "EV-PDB-9O76-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.58 }, "provenance": { "deposit_id": "9O76", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O76" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD THF complexed with SW-MK-NBD (Secondary Binding Site)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1B91" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains N,O,P,Q,R,V,W,X,Y,Z,b,c,d,e,f)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O6Z", "evidence_id": "EV-PDB-9O6Z-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.31 }, "provenance": { "deposit_id": "9O6Z", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O6Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD THF with SW-MK-NBD complexed in AD-related Binding Site" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1B91" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains K,L,M,N,O,R,S,Z,a,b)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O6Y", "evidence_id": "EV-PDB-9O6Y-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.72 }, "provenance": { "deposit_id": "9O6Y", "doi": null, "licence": "CC0 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"tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.58 }, "provenance": { "deposit_id": "9O6X", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O6X" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD THF incubated with SW-MK-NBD (Non-Symmetric Binding)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains F,G,H,I,J,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O6W", "evidence_id": "EV-PDB-9O6W-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.67 }, "provenance": { "deposit_id": "9O6W", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O6W" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD PHF complexed with SW-MK-NBD (Non Symmetric Binding Site)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1B91" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains F,G,H,I,J,N,O,P,Y,Z)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9O6V", "evidence_id": "EV-PDB-9O6V-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.72 }, "provenance": { "deposit_id": "9O6V", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9O6V" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Recombinant AD PHF complexed with SW-MK-NBD (PHF2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9MR8", "evidence_id": "EV-PDB-9MR8-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "9MR8", "doi": "10.1016/j.jmb.2025.169051", "licence": "CC0 1.0 (wwPDB archive 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"conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Fetal-tau of Microtubule-associated protein tau (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9H5G", "evidence_id": "EV-PDB-9H5G-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.48 }, "provenance": { "deposit_id": "9H5G", "doi": "10.7554/eLife.104778", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9H5G" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "PAD12 0N3R:0N4R tau PHF" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Tau peptide ARG-THR-PRO-SER-LEU-PRO-THR-PRO-PRO-THR (chains Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9GHK", "evidence_id": "EV-PDB-9GHK-2", "mappings": [], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.42 }, "provenance": { "deposit_id": 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"labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9GG8", "evidence_id": "EV-PDB-9GG8-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.1 }, "provenance": { "deposit_id": "9GG8", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9GG8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS214 peptide and covalent stabilizer 187" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "TW8" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Isoform Tau-G of Microtubule-associated protein tau (chains C,P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9GG7", "evidence_id": "EV-PDB-9GG7-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.24 }, "provenance": { "deposit_id": "9GG7", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9GG7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3 sigma dC - C38N in complex with Tau pS324 peptide and covalent stabilizer 187" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9GG6", "evidence_id": "EV-PDB-9GG6-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", 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"in_vitro", "ions": [], "ligands": [ "A1IKN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9GFA", "evidence_id": "EV-PDB-9GFA-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "9GFA", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9GFA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD33" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9G13", "evidence_id": "EV-PDB-9G13-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": 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"data_link": "https://www.rcsb.org/structure/9FVP", "evidence_id": "EV-PDB-9FVP-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.58 }, "provenance": { "deposit_id": "9FVP", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FVP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer JS24" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1IGH" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Microtubule-associated protein tau (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FVN", "evidence_id": "EV-PDB-9FVN-2", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "9FVN", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FVN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3 sigma in complex with Tau 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"source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3 sigma in complex with Tau pS214 peptide and covalent stabilizer LD12" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Microtubule-associated protein tau (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FH6", "evidence_id": "EV-PDB-9FH6-1", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": 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"conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.4, "salt_mM": null, "temperature_c": 11.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=31075", "evidence_id": "EV-BMRB-31075", "mappings": [], "molecule_id": "P10636", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr31075", "doi": "10.13018/BMR31075", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=31075" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Temperature-dependent structures of tau aggregates" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "BMRB data: 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34098", "evidence_id": "EV-BMRB-34098", "mappings": [], "molecule_id": "P10636", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34098", "doi": "10.13018/BMR34098", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34098" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure of Tau(254-290) bound to F-actin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "BMRB data: 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34099", "evidence_id": "EV-BMRB-34099", "mappings": [], "molecule_id": "P10636", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34099", "doi": "10.13018/BMR34099", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34099" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure of Tau(292-319) bound to F-actin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "BMRB data: 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34129", "evidence_id": "EV-BMRB-34129", "mappings": [], "molecule_id": "P10636", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34129", "doi": "10.13018/BMR34129", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34129" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure of Tau(254-268) bound to F-actin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.0, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=51483", "evidence_id": "EV-BMRB-51483", "mappings": [], "molecule_id": "P10636", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr51483", "doi": "10.13018/BMR51483", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=51483" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solid-state NMR assignment of fibrils formed by tau(297-391)" }, { "conditions": { "applied_force_pn": null, "buffer": "PBS", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample.", "ph": 7.4, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Microtubule-associated protein tau", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASD2E7/", "evidence_id": "EV-SASBDB-SASD2E7", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.071, "unit": "nm", "value": 2.662 }, "provenance": { "deposit_id": "SASD2E7", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASD2E7/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Tau preaggregation conformation of trunctated tau proteins" }, { "conditions": { "applied_force_pn": null, "buffer": "phosphate buffered saline", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16.2 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Microtubule-associated protein tau, Tau35 fragment", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLS4/", "evidence_id": "EV-SASBDB-SASDLS4", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.04, "unit": "nm", "value": 4.64 }, "provenance": { "deposit_id": "SASDLS4", "doi": "10.3389/fmolb.2021.779240", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLS4/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau" }, { "conditions": { "applied_force_pn": null, "buffer": "phosphate buffered saline", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 19.8 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Microtubule-associated protein tau, 2N3R isoform", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLT4/", "evidence_id": "EV-SASBDB-SASDLT4", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.28, "unit": "nm", "value": 6.33 }, "provenance": { "deposit_id": "SASDLT4", "doi": "10.3389/fmolb.2021.779240", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLT4/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau" }, { "conditions": { "applied_force_pn": null, "buffer": "phosphate buffered saline", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 23.5 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Microtubule-associated protein tau, 2N4R isoform", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLU4/", "evidence_id": "EV-SASBDB-SASDLU4", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.28, "unit": "nm", "value": 6.72 }, "provenance": { "deposit_id": "SASDLU4", "doi": "10.3389/fmolb.2021.779240", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLU4/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau" }, { "conditions": { "applied_force_pn": null, "buffer": "100 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 12.2 nm.", "ph": 6.8, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A)", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDV46/", "evidence_id": "EV-SASBDB-SASDV46", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.035, "unit": "nm", "value": 3.53 }, "provenance": { "deposit_id": "SASDV46", "doi": "10.1073/pnas.2425831122", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDV46/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain." }, { "conditions": { "applied_force_pn": null, "buffer": "100 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [ "partner: Polyubiquitin-B" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 13.3 nm.", "ph": 6.8, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A) with Polyubiquitin-B", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDV56/", "evidence_id": "EV-SASBDB-SASDV56", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.046, "unit": "nm", "value": 3.34 }, "provenance": { "deposit_id": "SASDV56", "doi": "10.1073/pnas.2425831122", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDV56/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain." }, { "conditions": { "applied_force_pn": null, "buffer": "100 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [ "partner: Polyubiquitin-B" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 12.08 nm.", "ph": 6.8, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A) with Polyubiquitin-B", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDV66/", "evidence_id": "EV-SASBDB-SASDV66", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.039, "unit": "nm", "value": 3.1 }, "provenance": { "deposit_id": "SASDV66", "doi": "10.1073/pnas.2425831122", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDV66/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain." }, { "conditions": { "applied_force_pn": null, "buffer": "100 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [ "partner: Polyubiquitin-B", "partner: Polyubiquitin-B" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 12.17 nm.", "ph": 6.8, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Isoform Tau-F of Microtubule-associated protein tau (C291A, K311C, K317C, C322A) with Polyubiquitin-B, Polyubiquitin-B", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDV76/", "evidence_id": "EV-SASBDB-SASDV76", "mappings": [ { "confidence": "medium", "justification": "Structure titled as bound to microtubules.", "rule": "tau-microtubule-title", "state_id": "tau-microtubule", "who": "rule:tau-microtubule-title" } ], "molecule_id": "P10636", "observable": { "type": "radius_of_gyration", "uncertainty": 0.016, "unit": "nm", "value": 3.28 }, "provenance": { "deposit_id": "SASDV76", "doi": "10.1073/pnas.2425831122", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDV76/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-441 of isoform P10636-8; evidence: small-angle X-ray scattering evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/7929085", "evidence_id": "EV-DISPROT-DP01100r001", "mappings": [ { "confidence": "medium", "justification": "DisProt region annotated as disorder.", "rule": "tau-disprot-disorder", "state_id": "tau-disordered", "who": "rule:tau-disprot-disorder" } ], "molecule_id": "P10636", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 441 }, "provenance": { "deposit_id": "DP01100r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01100" }, "reader": null, "source_kind": "literature", "technique": "saxs_sans", "title": "DisProt DP01100: disorder, residues 1-441" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-441 of isoform P10636-8; evidence: Fourier-transform infrared spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/14769047", "evidence_id": "EV-DISPROT-DP01100r027", "mappings": [ { "confidence": "medium", "justification": "DisProt region annotated as disorder.", "rule": "tau-disprot-disorder", "state_id": "tau-disordered", "who": "rule:tau-disprot-disorder" } ], "molecule_id": "P10636", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 441 }, "provenance": { "deposit_id": "DP01100r027", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01100" }, "reader": null, "source_kind": "literature", "technique": "ftir_raman", "title": "DisProt DP01100: disorder, residues 1-441" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-441 of isoform P10636-8; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/10805776", "evidence_id": "EV-DISPROT-DP01100r041", "mappings": [ { "confidence": "medium", "justification": "DisProt region annotated as disorder.", "rule": "tau-disprot-disorder", "state_id": "tau-disordered", "who": "rule:tau-disprot-disorder" } ], "molecule_id": "P10636", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 441 }, "provenance": { "deposit_id": "DP01100r041", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01100" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP01100: disorder, residues 1-441" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-441 of isoform P10636-8; evidence: small-angle X-ray scattering evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/18771286", "evidence_id": "EV-DISPROT-DP01100r042", "mappings": [ { "confidence": "medium", "justification": "DisProt region annotated as disorder.", "rule": "tau-disprot-disorder", "state_id": "tau-disordered", "who": "rule:tau-disprot-disorder" } ], "molecule_id": "P10636", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 441 }, "provenance": { "deposit_id": "DP01100r042", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP01100" }, "reader": null, "source_kind": "literature", "technique": "saxs_sans", "title": "DisProt DP01100: disorder, residues 1-441" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1-352 of isoform P10636-2; evidence: small-angle X-ray scattering evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/18771286", "evidence_id": "EV-DISPROT-DP03552r001", "mappings": [ { "confidence": "medium", "justification": "DisProt region annotated as disorder.", "rule": "tau-disprot-disorder", "state_id": "tau-disordered", "who": "rule:tau-disprot-disorder" } ], "molecule_id": "P10636", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 352 }, "provenance": { "deposit_id": "DP03552r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP03552" }, "reader": null, "source_kind": "literature", "technique": "saxs_sans", "title": "DisProt DP03552: disorder, residues 1-352" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-758", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/P10636", "evidence_id": "EV-AFDB-AF-P10636-F1", "mappings": [], "molecule_id": "P10636", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 49.22 }, "provenance": { "deposit_id": "AF-P10636-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/P10636" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-P10636-F1" } ], "models": [ { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-5O3L-1" ], "file": "models/P10636/tau-filament.cif", "format": "mmCIF", "model_id": "tau-filament-cif", "molecule_id": "P10636", "provenance": { "deposit_id": "5O3L", "doi": "10.1038/nature23002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/5O3L.cif" }, "state_id": "tau-filament" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-5O3L-1" ], "file": "models/P10636/tau-filament.pdb", "format": "PDB", "model_id": "tau-filament-pdb", "molecule_id": "P10636", "provenance": { "deposit_id": "5O3L", "doi": "10.1038/nature23002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/5O3L.pdb" }, "state_id": "tau-filament" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-6CVN-3" ], "file": "models/P10636/tau-microtubule.cif", "format": "mmCIF", "model_id": "tau-microtubule-cif", "molecule_id": "P10636", "provenance": { "deposit_id": "6CVN", "doi": "10.1126/science.aat1780", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/6CVN.cif" }, "state_id": "tau-microtubule" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-6CVN-3" ], "file": "models/P10636/tau-microtubule.pdb", "format": "PDB", "model_id": "tau-microtubule-pdb", "molecule_id": "P10636", "provenance": { "deposit_id": "6CVN", "doi": "10.1126/science.aat1780", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/6CVN.pdb" }, "state_id": "tau-microtubule" } ], "molecule": { "components": [], "domains": [], "gene": "MAPT", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P10636" }, "ligands": [], "modifications": [ { "kind": "ptm", "name": "N-acetylalanine", "position": 2, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine; 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in tau and PHF-tau; partial", "position": 596, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 598, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by PHK", "position": 602, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 607, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 610, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 615, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by PHK", "position": 622, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6,N6-dimethyllysine; alternate", "position": 628, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 628, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 634, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 638, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 641, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; 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by CK1 and PDPK1", "position": 721, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 726, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CaMK2 and TTBK1", "position": 733, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by PDPK1 and TTBK1", "position": 739, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine; by TTBK1", "position": 744, "source": "UniProtKB" } ], "molecule_id": "P10636", "molecule_type": "protein", "name": "Microtubule-associated protein tau", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P10636", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10636/entry" }, "sequence": "MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL", "sequence_length": 758 }, "molecule_id": "P10636", "states": [ { "assumptions": [ "No observed structure of the free monomer exists; the state is defined by disorder evidence (DisProt, NMR, SAXS).", "Treated as a single ensemble; transient local structure is not resolved. No model is exported." ], "basis": "inferred", "description": "Intrinsically disordered monomer in solution. No observed structure.", "family_label": null, "molecule_id": "P10636", "name": "disordered monomer", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P10636.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P10636.yaml" }, "representative_model": null, "secondary_structure": null, "state_id": "tau-disordered", "status": "draft" }, { "assumptions": [], "basis": "observed", "description": "Cross-beta filament core, as in 5O3L (paired helical filament from Alzheimer's disease brain). Filament folds are not separated.", "family_label": null, "molecule_id": "P10636", "name": "amyloid filament", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P10636.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P10636.yaml" }, "representative_model": "tau-filament-cif", "secondary_structure": null, "state_id": "tau-filament", "status": "draft" }, { "assumptions": [], "basis": "observed", "description": "Repeat region bound along the microtubule surface, as in 6CVN.", "family_label": null, "molecule_id": "P10636", "name": "microtubule-bound", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P10636.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P10636.yaml" }, "representative_model": "tau-microtubule-cif", "secondary_structure": null, "state_id": "tau-microtubule", "status": "draft" } ], "transitions": [] }