{ "conflicts": [], "coverage": { "cells": { "CaM-Ca4-collapsed": { "af_prediction": 0, "cryoem": 0, "force_spectroscopy": 0, "md": 0, "nmr_dynamics": 0, "nmr_shifts": 0, "nmr_structure": 0, "saxs_sans": 0, "xray": 1 }, "CaM-Ca4-extended": { "af_prediction": 0, "cryoem": 0, "force_spectroscopy": 0, "md": 0, "nmr_dynamics": 0, "nmr_shifts": 0, "nmr_structure": 0, "saxs_sans": 0, "xray": 1 } }, "data_levels": { "CaM-Ca4-collapsed": { "xray": "processed" }, "CaM-Ca4-extended": { "xray": "processed" } }, "single_method_states": [ "CaM-Ca4-extended", "CaM-Ca4-collapsed" ], "states": [ "CaM-Ca4-extended", "CaM-Ca4-collapsed" ], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_dynamics", "nmr_shifts", "saxs_sans", "force_spectroscopy", "af_prediction", "md" ], "unmapped_evidence": 398 }, "curation": { "as_of": "2026-10-19", "curator": "draft (unreviewed)", "file": "P0DP23.yaml", "status": "draft" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1C6W" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains A,B,H,M)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/10NL", "evidence_id": "EV-PDB-10NL-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.81 }, "provenance": { "deposit_id": "10NL", "doi": "10.1126/sciadv.aef8456", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/10NL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Xenopus KCNQ1 in complex with UCL2077" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "CALMODULIN (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1CDL", "evidence_id": "EV-PDB-1CDL-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "1CDL", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1CDL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "EOH" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "CALMODULIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1CLL", "evidence_id": "EV-PDB-1CLL-1", "mappings": [ { "confidence": "high", "justification": "Four Ca2+ bound, extended dumbbell; representative for CaM-Ca4-extended.", "rule": "curator_assignment", "state_id": "CaM-Ca4-extended", "who": "curator:draft (unreviewed)" } ], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "1CLL", "doi": "10.1016/0022-2836(92)90324-D", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1CLL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CALMODULIN STRUCTURE REFINED AT 1.7 ANGSTROMS RESOLUTION" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MYR" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -183.15 }, "construct": { "description": "CALMODULIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1L7Z", "evidence_id": "EV-PDB-1L7Z-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "1L7Z", "doi": "10.1038/sj.emboj.7600093", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1L7Z" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CMP", "POP", "YB" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SK6", "evidence_id": "EV-PDB-1SK6-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "1SK6", "doi": "10.1074/jbc.M402689200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SK6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -83.15 }, "construct": { "description": "Calmodulin 2 (chains O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1XFZ", "evidence_id": "EV-PDB-1XFZ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.25 }, "provenance": { "deposit_id": "1XFZ", "doi": "10.1038/sj.emboj.7600574", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1XFZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NI" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin 2 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BE6", "evidence_id": "EV-PDB-2BE6-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "2BE6", "doi": "10.1038/nsmb1027", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BE6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2HF5", "evidence_id": "EV-PDB-2HF5-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2HF5", "doi": "10.1110/ps.072777107", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2HF5" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "The structure and function of a novel two-site calcium-binding fragment of calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LL7", "evidence_id": "EV-PDB-2LL7-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LL7", "doi": "10.1021/bi300327z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LL7" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR structure of CaM bound to the eNOS CaM binding domain peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LQC", "evidence_id": "EV-PDB-2LQC-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LQC", "doi": "10.3389/fnmol.2012.00038", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LQC" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR solution structure of a Ca2+-Calmodulin with a binding motif (NSCaTE) peptide from the N-terminal cytoplasmic domain of the L-type Voltage-Cated Calcium Channel alpha1C subunit" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LL6", "evidence_id": "EV-PDB-2LL6-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LL6", "doi": "10.1021/bi300327z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LL6" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR structure of CaM bound to iNOS CaM binding domain peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LGF", "evidence_id": "EV-PDB-2LGF-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LGF", "doi": "10.1074/jbc.M112.373373", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LGF" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of L-selectin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2L7L", "evidence_id": "EV-PDB-2L7L-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2L7L", "doi": "10.1007/s10858-011-9495-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2L7L" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "HLT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2KUH", "evidence_id": "EV-PDB-2KUH-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2KUH", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2KUH" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Halothane binds to druggable sites in calcium-calmodulin: Solution structure of halothane-CaM C-terminal domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "HLT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2KUG", "evidence_id": "EV-PDB-2KUG-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2KUG", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2KUG" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM N-terminal domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2KNE", "evidence_id": "EV-PDB-2KNE-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2KNE", "doi": "10.1074/jbc.M109.060491", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2KNE" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Calmodulin wraps around its binding domain in the plasma membrane CA2+ pump anchored by a novel 18-1 motif" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "TB" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K61", "evidence_id": "EV-PDB-2K61-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K61", "doi": "10.1021/ja8080764", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K61" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of CaM complexed to DAPk peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "LA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR 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"data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K0F", "evidence_id": "EV-PDB-2K0F-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K0F", "doi": "10.1016/j.str.2008.02.017", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K0F" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K0E", "evidence_id": "EV-PDB-2K0E-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K0E", "doi": "10.1016/j.str.2008.02.017", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K0E" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2JZI", "evidence_id": "EV-PDB-2JZI-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2JZI", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2JZI" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2I08", "evidence_id": "EV-PDB-2I08-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "2I08", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2I08" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Solvation effect in conformational changes of EF-hand proteins: X-ray structure of Ca2+-saturated double mutant Q41L-K75I of N-domain of calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2F3Z", "evidence_id": "EV-PDB-2F3Z-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2F3Z", "doi": "10.1016/j.str.2005.09.021", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2F3Z" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin/IQ-AA domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2F3Y", "evidence_id": "EV-PDB-2F3Y-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.45 }, "provenance": { "deposit_id": "2F3Y", "doi": "10.1016/j.str.2005.09.021", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2F3Y" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin/IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/22RJ", "evidence_id": "EV-PDB-22RJ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.82 }, "provenance": { "deposit_id": "22RJ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/22RJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ3-CaM in apo state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1ZUZ", "evidence_id": "EV-PDB-1ZUZ-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.91 }, "provenance": { "deposit_id": "1ZUZ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1ZUZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin in complex with a mutant peptide from human DRP-1 kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "EMA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1ZOT", "evidence_id": "EV-PDB-1ZOT-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1ZOT", "doi": "10.1038/sj.emboj.7600800", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1ZOT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "crystal structure analysis of the CyaA/C-Cam with PMEAPP" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1YRU", "evidence_id": "EV-PDB-1YRU-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "1YRU", "doi": "10.1038/sj.emboj.7600800", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1YRU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1YRT", "evidence_id": "EV-PDB-1YRT-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "1YRT", "doi": "10.1038/sj.emboj.7600800", "licence": "CC0 1.0 (wwPDB archive data)", 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"Å", "value": 1.7 }, "provenance": { "deposit_id": "1YR5", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1YR5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "1.7-A structure of calmodulin bound to a peptide from DAP kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MPD", "TBU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1Y6W", "evidence_id": "EV-PDB-1Y6W-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "1Y6W", "doi": "10.1016/j.jmb.2005.01.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1Y6W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Trapped intermediate of calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -83.15 }, "construct": { "description": "Calmodulin 2 (chains O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1XFY", "evidence_id": "EV-PDB-1XFY-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "1XFY", "doi": "10.1038/sj.emboj.7600574", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1XFY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of anthrax edema factor (EF) in complex with calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -83.15 }, "construct": { "description": "Calmodulin 2 (chains O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1XFX", "evidence_id": "EV-PDB-1XFX-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "1XFX", "doi": "10.1038/sj.emboj.7600574", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1XFX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CMP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -83.15 }, "construct": { "description": "Calmodulin 2 (chains O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1XFW", "evidence_id": "EV-PDB-1XFW-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "1XFW", "doi": "10.1038/sj.emboj.7600574", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1XFW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3AT", "CA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -83.15 }, "construct": { "description": "Calmodulin 2 (chains O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1XFV", "evidence_id": "EV-PDB-1XFV-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.35 }, "provenance": { "deposit_id": "1XFV", "doi": "10.1038/sj.emboj.7600574", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1XFV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -83.15 }, "construct": { "description": "Calmodulin 2 (chains O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1XFU", "evidence_id": "EV-PDB-1XFU-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.35 }, "provenance": { "deposit_id": "1XFU", "doi": "10.1038/sj.emboj.7600574", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1XFU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1WRZ", "evidence_id": "EV-PDB-1WRZ-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "1WRZ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1WRZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin complexed with a peptide from a human death-associated protein kinase" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SW8", "evidence_id": "EV-PDB-1SW8-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1SW8", "doi": "10.1073/pnas.0308641101", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SW8" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the N-terminal domain of Human N60D calmodulin refined with paramagnetism based strategy" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "APC", "CA", "YB" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1S26", "evidence_id": "EV-PDB-1S26-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "1S26", "doi": "10.1016/j.bbrc.2004.03.046", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1S26" }, 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"10.1073/pnas.0306552101", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1PK0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the EF3-CaM complexed with PMEApp" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 2.05 }, "construct": { "description": "CALCIUM-BINDING HEXADECAPEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1NKF", "evidence_id": "EV-PDB-1NKF-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1NKF", "doi": "10.1073/pnas.96.3.903", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1NKF" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "CALCIUM-BINDING PEPTIDE, NMR, 30 STRUCTURES" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "DOT", "YB" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -73.15 }, "construct": { "description": "calmodulin (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1LVC", "evidence_id": "EV-PDB-1LVC-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "1LVC", "doi": "10.1093/emboj/cdf681", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1LVC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CALMODULIN (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1K93", "evidence_id": "EV-PDB-1K93-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "1K93", "doi": "10.1038/415396a", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1K93" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3AT", "CA", "YB" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CALMODULIN (chains D,E,F)", 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"data_link": "https://www.rcsb.org/structure/2M0J", "evidence_id": "EV-PDB-2M0J-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2M0J", "doi": "10.1080/07391102.2012.703069", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2M0J" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "3D Structure of Calmodulin and Calmodulin binding domain of Olfactory cyclic nucleotide-gated ion channel complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.7, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2M0K", "evidence_id": "EV-PDB-2M0K-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2M0K", "doi": "10.1080/07391102.2012.703069", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2M0K" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "3D Structure of Calmodulin and Calmodulin Binding Domain of Rat Olfactory Cyclic Nucleotide-Gated Ion Channel" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in 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as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MG5", "evidence_id": "EV-PDB-2MG5-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MG5", "doi": "10.1021/bi401466s", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MG5" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of Calmodulin bound to the target peptide of Endothelial Nitrogen Oxide Synthase phosphorylated at Thr495" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "4DY", "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2N27", "evidence_id": "EV-PDB-2N27-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2N27", "doi": "10.1002/1873-3468.12267", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2N27" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Competitive inhibition of TRPV1 calmodulin interaction by vanilloids" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "human calmodulin/connexin-36 peptide hybrid (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2N6A", "evidence_id": "EV-PDB-2N6A-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2N6A", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2N6A" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR structure of a human 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"description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3BYA", "evidence_id": "EV-PDB-3BYA-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "3BYA", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3BYA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of a Calmodulin Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3DVJ", "evidence_id": "EV-PDB-3DVJ-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "3DVJ", "doi": "10.1016/j.str.2008.07.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3DVJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Ca2+/CaM-CaV2.2 IQ domain (without cloning artifact, HM to TV) complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3DVM", "evidence_id": "EV-PDB-3DVM-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "3DVM", "doi": "10.1016/j.str.2008.07.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3DVM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not 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pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.7, "salt_mM": null, "temperature_c": -160.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3EWV", "evidence_id": "EV-PDB-3EWV-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "3EWV", "doi": "10.1107/S1399004714006919", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3EWV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of calmodulin complexed with a peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3G43", "evidence_id": "EV-PDB-3G43-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "3G43", "doi": "10.1073/pnas.0807487106", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3G43" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "FMN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HR4", "evidence_id": "EV-PDB-3HR4-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "3HR4", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HR4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human iNOS Reductase and Calmodulin Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3J41", "evidence_id": "EV-PDB-3J41-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 25.0 }, "provenance": { "deposit_id": "3J41", "doi": "10.1038/nsmb.2630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3J41" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Pseudo-atomic model of the Aquaporin-0/Calmodulin complex derived from electron microscopy" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SUI", "evidence_id": "EV-PDB-3SUI-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.95 }, "provenance": { "deposit_id": "3SUI", "doi": "10.1085/jgp.201210810", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SUI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 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"10.1107/S1399004713024437", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4BW7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin in complex with strontium" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CALMODULIN (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4BW8", "evidence_id": "EV-PDB-4BW8-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "4BW8", "doi": "10.1107/S1399004713024437", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4BW8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin with small bend in central helix" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "AOV", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CALMODULIN (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4BYF", "evidence_id": "EV-PDB-4BYF-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": 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"https://www.rcsb.org/structure/6CNN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state I" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6CNO", "evidence_id": "EV-PDB-6CNO-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.7 }, "provenance": { "deposit_id": "6CNO", "doi": "10.1126/science.aas9466", "licence": "CC0 1.0 (wwPDB archive 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"6DAD", "doi": "10.1073/pnas.1808733115", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6DAD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 10.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6DAE", "evidence_id": "EV-PDB-6DAE-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "6DAE", "doi": "10.1073/pnas.1808733115", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6DAE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "2.0 Angstrom crystal structure of the D95V Ca/CaM:CaV1.2 IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6DAF", "evidence_id": "EV-PDB-6DAF-1", "mappings": [], "molecule_id": "P0DP23", 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"evidence_id": "EV-PDB-6DAH-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.502 }, "provenance": { "deposit_id": "6DAH", "doi": "10.1073/pnas.1808733115", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6DAH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "2.5 Angstrom crystal structure of the N97S CaM mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6E2F", "evidence_id": "EV-PDB-6E2F-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "6E2F", "doi": "10.1126/sciadv.aau6088", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6E2F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human TRPV6 in complex with Calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6E2G", "evidence_id": "EV-PDB-6E2G-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "6E2G", "doi": "10.1126/sciadv.aau6088", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6E2G" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of rat TRPV6 in complex with Calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "J6P", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6EEB", "evidence_id": "EV-PDB-6EEB-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.96 }, "provenance": { "deposit_id": "6EEB", "doi": "10.1073/pnas.1818547116", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6EEB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin in complex with malbrancheamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6FEG", "evidence_id": "EV-PDB-6FEG-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6FEG", "doi": "10.1073/pnas.1800235115", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6FEG" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of CaM/Kv7.2-hAB Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6FEH", "evidence_id": "EV-PDB-6FEH-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6FEH", "doi": "10.1073/pnas.1800235115", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6FEH" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of CaM/Kv7.2-hAB Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.45, "salt_mM": null, "temperature_c": 24.95 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GDK", "evidence_id": "EV-PDB-6GDK-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6GDK", "doi": "10.1073/pnas.1808733115", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GDK" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Calcium bound form of human calmodulin mutant F141L" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.55, "salt_mM": null, "temperature_c": 24.95 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GDL", "evidence_id": "EV-PDB-6GDL-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6GDL", "doi": "10.1073/pnas.1808733115", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GDL" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Calmodulin mutant - F141L apo-form Unstructured C-domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,C,E,G)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6HCS", "evidence_id": "EV-PDB-6HCS-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "6HCS", "doi": "10.1063/1.5053466", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6HCS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of CaM-peptide complex containing AzF at position 108" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "EDO", "GOL", "NA", "TLA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Myosin light chain kinase 2, skeletal/cardiac muscle,Unconventional myosin-X,Green fluorescent protein,Calmodulin-1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6HR1", "evidence_id": "EV-PDB-6HR1-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.901 }, "provenance": { "deposit_id": "6HR1", "doi": "10.1016/j.str.2021.09.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6HR1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the YFPnano fusion protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6JI8", "evidence_id": "EV-PDB-6JI8-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "6JI8", "doi": "10.1038/s41586-019-1377-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6JI8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of RyR2 (F/apoCaM 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"title": "Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6B8N", "evidence_id": "EV-PDB-6B8N-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.201 }, "provenance": { "deposit_id": "6B8N", "doi": "10.1016/j.neuron.2018.01.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6B8N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7T2Q", "evidence_id": "EV-PDB-7T2Q-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.95 }, "provenance": { "deposit_id": "7T2Q", "doi": "10.1038/s41467-022-34530-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7T2Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "PEGylated Calmodulin-1 (K148U)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "PEV", "PGV", "Y01" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SX4", "evidence_id": "EV-PDB-7SX4-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "7SX4", "doi": "10.1038/s41586-021-04313-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SX4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "PEV", "PGV", "Y01" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SX3", "evidence_id": "EV-PDB-7SX3-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "7SX3", "doi": "10.1038/s41586-021-04313-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SX3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7SHQ", "evidence_id": "EV-PDB-7SHQ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.34 }, "provenance": { "deposit_id": "7SHQ", "doi": "10.1126/sciadv.abo2039", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7SHQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "85H", "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7PU9", "evidence_id": "EV-PDB-7PU9-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.279 }, "provenance": { "deposit_id": "7PU9", "doi": "10.1186/s12915-022-01381-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7PU9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of CaM in complex with CDZ (form 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "85H", "CA", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7PSZ", "evidence_id": "EV-PDB-7PSZ-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.898 }, "provenance": { "deposit_id": "7PSZ", "doi": "10.1186/s12915-022-01381-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7PSZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of CaM in complex with CDZ (form 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7L8V", "evidence_id": "EV-PDB-7L8V-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "7L8V", "doi": "10.1016/j.jbc.2022.102701", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7L8V" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR Structure of half-calcified calmodulin mutant (CaMEF12) bound to the IQ-motif of CaV1.2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "EDO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KL5", "evidence_id": "EV-PDB-7KL5-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "7KL5", "doi": "10.1021/acs.biochem.1c00152", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KL5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues: Phe4246 to Val4271" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains AAA)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7BF2", "evidence_id": "EV-PDB-7BF2-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.43 }, "provenance": { "deposit_id": "7BF2", "doi": "10.1016/j.crstbi.2021.05.001", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7BF2" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended 1:2 binding mode" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACE", "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains AAA)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7BF1", "evidence_id": "EV-PDB-7BF1-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.24 }, "provenance": { "deposit_id": "7BF1", "doi": "10.1016/j.crstbi.2021.05.001", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7BF1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2 binding mode" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "EDO", "FMT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "rsGCamP1.3 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7AUG", "evidence_id": "EV-PDB-7AUG-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.04 }, "provenance": { "deposit_id": "7AUG", "doi": "10.1038/s41587-021-01100-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7AUG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of rsGCamP1.3 in the ON state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6ZBI", "evidence_id": "EV-PDB-6ZBI-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6ZBI", "doi": "10.7554/eLife.60889", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6ZBI" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Ternary complex of Calmodulin bound to 2 molecules of NHE1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YNU", "evidence_id": "EV-PDB-6YNU-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.12 }, "provenance": { "deposit_id": "6YNU", "doi": "10.1002/advs.202003630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YNU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CaM-P458 complex (crystal form 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YNS", "evidence_id": "EV-PDB-6YNS-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.94 }, "provenance": { "deposit_id": "6YNS", "doi": "10.1002/advs.202003630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YNS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CaM-P458 complex (crystal form 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "rsCGaMP (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YA9", "evidence_id": "EV-PDB-6YA9-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.15 }, "provenance": { "deposit_id": "6YA9", "doi": "10.1038/s41587-021-01100-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YA9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of rsGCaMP in the ON state (non-illuminated)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": 24.95 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6Y95", "evidence_id": "EV-PDB-6Y95-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6Y95", "doi": "10.1074/jbc.RA120.013430", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6Y95" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Ca2+-free Calmodulin mutant N53I" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.57, "salt_mM": null, "temperature_c": 24.95 }, "construct": { "description": "Calmodulin (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6Y94", "evidence_id": "EV-PDB-6Y94-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6Y94", "doi": "10.1074/jbc.RA120.013430", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6Y94" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Ca2+-bound Calmodulin mutant N53I" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6Y4P", "evidence_id": "EV-PDB-6Y4P-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.13325578805 }, "provenance": { "deposit_id": "6Y4P", "doi": "10.1074/jbc.RA120.013430", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6Y4P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-2 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6Y4O", "evidence_id": "EV-PDB-6Y4O-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.83549081766 }, "provenance": { "deposit_id": "6Y4O", "doi": "10.1074/jbc.RA120.013430", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6Y4O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CL", "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "T4Lnano,Endolysin,Calmodulin,Endolysin,Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6XYR", "evidence_id": "EV-PDB-6XYR-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.079 }, "provenance": { "deposit_id": "6XYR", "doi": "10.1016/j.str.2021.09.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6XYR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the T4Lnano fusion protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains AAA)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6XY3", "evidence_id": "EV-PDB-6XY3-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "6XY3", "doi": "10.1242/jcs.258796", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6XY3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "2.0 Angstrom crystal structure of Ca/CaM N53I:RyR2 peptide complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains AAA)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6XXX", "evidence_id": "EV-PDB-6XXX-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.25 }, "provenance": { "deposit_id": "6XXX", "doi": "10.1242/jcs.258796", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6XXX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6X36", "evidence_id": "EV-PDB-6X36-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.7 }, "provenance": { "deposit_id": "6X36", "doi": "10.1038/s41467-021-21141-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6X36" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Pig R615C RyR1 in complex with CaM, EGTA (class 3, closed)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6X35", "evidence_id": "EV-PDB-6X35-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.2 }, "provenance": { "deposit_id": "6X35", "doi": "10.1038/s41467-021-21141-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6X35" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Pig R615C RyR1 in complex with CaM, EGTA (class 1, open)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6X33", "evidence_id": "EV-PDB-6X33-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.2 }, "provenance": { "deposit_id": "6X33", "doi": "10.1038/s41467-021-21141-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6X33" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Wt pig RyR1 in complex with apoCaM, EGTA condition (class 3, open)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6X32", "evidence_id": "EV-PDB-6X32-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "6X32", "doi": "10.1038/s41467-021-21141-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6X32" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Wt pig RyR1 in complex with apoCaM, EGTA condition (class 1 and 2, closed)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "PT5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,E,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6V01", "evidence_id": "EV-PDB-6V01-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "6V01", "doi": "10.1016/j.cell.2019.12.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6V01" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-KCNE3-CaM complex with PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,E,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6V00", "evidence_id": "EV-PDB-6V00-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "6V00", "doi": "10.1016/j.cell.2019.12.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6V00" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-KCNE3-CaM complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6UZZ", "evidence_id": "EV-PDB-6UZZ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "6UZZ", "doi": "10.1016/j.cell.2019.12.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6UZZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-CaM complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6U3D", "evidence_id": "EV-PDB-6U3D-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "6U3D", "doi": "10.1113/JP279307", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6U3D" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "1.75 Angstrom crystal structure of the N53I Ca-CaM:CaV1.2 IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6U3B", "evidence_id": "EV-PDB-6U3B-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "6U3B", "doi": "10.1113/JP279307", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6U3B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "1.7 Angstrom crystal structure of the Q135P Ca-CaM:CaV1.2 IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6U3A", "evidence_id": "EV-PDB-6U3A-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "6U3A", "doi": "10.1113/JP279307", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6U3A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "1.65 Angstrom crystal structure of the N97S Ca-CaM:CaV1.2 IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,C,E,G,I,K,M,O,Q,S)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6U39", "evidence_id": "EV-PDB-6U39-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "6U39", "doi": "10.1113/JP279307", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6U39" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "rsGCaMP (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6TV7", "evidence_id": "EV-PDB-6TV7-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "6TV7", "doi": "10.1038/s41587-021-01100-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6TV7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of rsGCaMP in the OFF state (illuminated)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PBY", "evidence_id": "EV-PDB-6PBY-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.67 }, "provenance": { "deposit_id": "6PBY", "doi": "10.7554/eLife.49188", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PBY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PBX", "evidence_id": "EV-PDB-6PBX-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "6PBX", "doi": "10.7554/eLife.49188", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PBX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,D,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PAW", "evidence_id": "EV-PDB-6PAW-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.953 }, 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"unit": "Å", "value": 2.05 }, "provenance": { "deposit_id": "6OS4", "doi": "10.1126/scisignal.aaz0344", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6OS4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin in complex with farnesyl cysteine methyl ester" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "LMJ", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6O5G", "evidence_id": "EV-PDB-6O5G-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.89 }, "provenance": { "deposit_id": "6O5G", "doi": "10.1073/pnas.1818547116", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6O5G" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Calmodulin in complex with isomalbrancheamide D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N5W", "evidence_id": "EV-PDB-6N5W-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.15 }, "provenance": { "deposit_id": "6N5W", "doi": "10.1074/jbc.RA118.006857", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N5W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the Ca2+/CaM complex with independent peptides of Kv7.4 (KCNQ4) A & B domains" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6MUE", "evidence_id": "EV-PDB-6MUE-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "6MUE", "doi": "10.1073/pnas.1818618116", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6MUE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Voltage-gated sodium channel NaV1.4 IQ domain in complex with Ca2+/Calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "KN9" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6M7H", "evidence_id": "EV-PDB-6M7H-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "6M7H", "doi": "10.1016/j.ceca.2019.102063", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6M7H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of calmodulin with KN93" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "F0U", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6M2W", "evidence_id": "EV-PDB-6M2W-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "6M2W", "doi": "10.1038/s41589-020-0627-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6M2W" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "AMP", "CA", "CL", "PG4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6K4R", "evidence_id": "EV-PDB-6K4R-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.109 }, "provenance": { "deposit_id": "6K4R", "doi": "10.1038/s41586-019-1439-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6K4R" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SidJ-CaM-AMP ternary complex at 3.11 A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6K4L", "evidence_id": "EV-PDB-6K4L-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.949 }, "provenance": { "deposit_id": "6K4L", "doi": "10.1038/s41586-019-1439-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6K4L" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Se-labelled SidJ complex with CaM at 2.95 A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6K4K", "evidence_id": "EV-PDB-6K4K-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.715 }, "provenance": { "deposit_id": "6K4K", "doi": "10.1038/s41586-019-1439-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6K4K" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SidJ-CaM binary complex at 2.71 A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6JV2", "evidence_id": "EV-PDB-6JV2-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.4 }, "provenance": { "deposit_id": "6JV2", "doi": "10.1038/s41586-019-1377-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6JV2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6JRS", "evidence_id": "EV-PDB-6JRS-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "6JRS", "doi": "10.1038/s41586-019-1377-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6JRS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of RyR2 (*F/A/C/L-Ca2+/Ca2+-CaM dataset)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6JIY", "evidence_id": "EV-PDB-6JIY-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "6JIY", "doi": "10.1038/s41586-019-1377-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6JIY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6JIU", "evidence_id": "EV-PDB-6JIU-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.2 }, "provenance": { "deposit_id": "6JIU", "doi": "10.1038/s41586-019-1377-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6JIU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of RyR2 (F/A/C/L-Ca2+/Ca2+CaM dataset)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "KVR", "L9R", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,D,E,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TZC", "evidence_id": "EV-PDB-7TZC-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.45 }, "provenance": { "deposit_id": "7TZC", "doi": "10.1016/j.str.2022.04.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TZC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "A drug and ATP binding site in type 1 ryanodine receptor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7U9T", "evidence_id": "EV-PDB-7U9T-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.68 }, "provenance": { "deposit_id": "7U9T", "doi": "10.1126/sciadv.abo1272", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7U9T" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7UA3", "evidence_id": "EV-PDB-7UA3-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.97 }, "provenance": { "deposit_id": "7UA3", "doi": "10.1126/sciadv.abo1272", "licence": "CC0 1.0 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2.93 }, "provenance": { "deposit_id": "7UA4", "doi": "10.1126/sciadv.abo1272", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7UA4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VMB", "evidence_id": "EV-PDB-7VMB-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.99777371992 }, "provenance": { "deposit_id": "7VMB", "doi": "10.1083/jcb.202307117", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VMB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of IQSEC1-IQ motif, Sec7PH tandem in complex with calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3NY", "CA", "MPD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -153.15 }, "construct": { "description": "AlleyCat (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VUS", "evidence_id": "EV-PDB-7VUS-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "7VUS", "doi": "10.1038/s41586-022-05278-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VUS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of AlleyCat9 with 5-nitro-benzotriazole" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3NY", "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -153.15 }, "construct": { "description": "AlleyCat (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VUU", "evidence_id": "EV-PDB-7VUU-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.95 }, "provenance": { "deposit_id": "7VUU", "doi": "10.1038/s41586-022-05278-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VUU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of AlleyCat10 with inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -80.0 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VVH", "evidence_id": "EV-PDB-7VVH-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.296 }, "provenance": { "deposit_id": "7VVH", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VVH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E140G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WJI", "evidence_id": "EV-PDB-7WJI-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.5 }, "provenance": { "deposit_id": "7WJI", "doi": "10.1038/s41421-022-00392-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WJI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Architecture of the human NALCN channelosome" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NCA", "SO4", "branched: alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "Calmodulin-1 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WR3", "evidence_id": "EV-PDB-7WR3-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.87 }, "provenance": { "deposit_id": "7WR3", "doi": "10.1038/s41594-022-00888-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WR3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of MBP-fused OspC3 in complex with calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WR4", "evidence_id": "EV-PDB-7WR4-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.75 }, "provenance": { "deposit_id": "7WR4", "doi": "10.1038/s41594-022-00888-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WR4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of OspC3-calmodulin-caspase-4 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "5ZV" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WR5", "evidence_id": "EV-PDB-7WR5-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "7WR5", "doi": "10.1038/s41594-022-00888-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WR5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of OspC3-calmodulin-caspase-4 complex binding with 2'-aF-NAD+" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WZS", "evidence_id": "EV-PDB-7WZS-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "7WZS", "doi": "10.1128/mbio.00690-22", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WZS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Chromobacterium violaceum effector CopC in complex with host calmodulin and caspase-7" }, { 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"source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of CopC-CaM-caspase-3 with ADPR-deacylization" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "IMD", "PG4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7ZRP", "evidence_id": "EV-PDB-7ZRP-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.65 }, "provenance": { "deposit_id": "7ZRP", "doi": "10.1016/j.jbc.2022.102777", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": 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"construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8EP1", "evidence_id": "EV-PDB-8EP1-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 5.4 }, "provenance": { "deposit_id": "8EP1", "doi": "10.1073/pnas.2214151119", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8EP1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Eag Kv channel with voltage sensor in the down conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP", "ATP", "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8FNY", "evidence_id": "EV-PDB-8FNY-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.22 }, "provenance": { "deposit_id": "8FNY", "doi": "10.1073/pnas.2300902120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8FNY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.9, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8FO6", "evidence_id": "EV-PDB-8FO6-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.553 }, "provenance": { "deposit_id": "8FO6", "doi": "10.1073/pnas.2300902120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8FO6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP", "CA", "EKI", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GM5", "evidence_id": "EV-PDB-8GM5-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.12 }, "provenance": { "deposit_id": "8GM5", "doi": "10.1016/j.jbc.2023.104813", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GM5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P0T", "PIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,E,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J01", "evidence_id": "EV-PDB-8J01-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8J01", "doi": "10.1038/s41467-023-42416-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J01" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM in complex with CBD and PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P0T", "PIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,E,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J02", "evidence_id": "EV-PDB-8J02-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8J02", "doi": "10.1038/s41467-023-42416-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J02" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P0T" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,H,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J03", "evidence_id": "EV-PDB-8J03-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8J03", "doi": "10.1038/s41467-023-42416-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J03" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state I" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9MF" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,E,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J04", "evidence_id": "EV-PDB-8J04-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8J04", "doi": "10.1038/s41467-023-42416-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J04" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM-HN37 complex in the presence of PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,E,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J05", "evidence_id": "EV-PDB-8J05-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8J05", "doi": "10.1038/s41467-023-42416-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J05" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM complex in the presence of PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GDP", "GTP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains W)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J07", "evidence_id": "EV-PDB-8J07-52", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.1 }, "provenance": { "deposit_id": "8J07", "doi": "10.1038/s41586-023-06140-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J07" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "96nm repeat of human respiratory doublet microtubule and associated axonemal complexes" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FAR" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains D,H,L,P)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JFK", "evidence_id": "EV-PDB-8JFK-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8JFK", "doi": "10.1038/s41467-024-47049-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JFK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "PhK holoenzyme in inactive state, muscle isoform" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Interleukin-23 receptor,Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OE4", "evidence_id": "EV-PDB-8OE4-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8OE4", "doi": "10.1038/s41594-023-01190-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OE4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SIK", "evidence_id": "EV-PDB-8SIK-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8SIK", "doi": "10.1073/pnas.2301985120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SIK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "KCNQ1 with voltage sensor in the up conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SIM", "evidence_id": "EV-PDB-8SIM-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 6.2 }, "provenance": { "deposit_id": "8SIM", "doi": "10.1073/pnas.2301985120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SIM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "KCNQ1 with voltage sensor in the intermediate conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P0T" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J00", "evidence_id": "EV-PDB-8J00-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8J00", "doi": "10.1038/s41467-023-42416-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J00" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM in complex with CBD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "7PN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8IJK", "evidence_id": "EV-PDB-8IJK-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8IJK", "doi": "10.1038/s41589-023-01515-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8IJK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "human KCNQ2-CaM-Ebio1 complex in the presence of PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP", "CA", "EKI", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GM4", "evidence_id": "EV-PDB-8GM4-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.12 }, "provenance": { "deposit_id": "8GM4", "doi": "10.1016/j.jbc.2023.104813", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GM4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DVE", "evidence_id": "EV-PDB-8DVE-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.84 }, "provenance": { "deposit_id": "8DVE", "doi": "10.1126/sciadv.adf4936", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DVE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "RyR1 in presence of IpCa-T26E phosphomimetic and activating ligands" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.64, "salt_mM": null, "temperature_c": 24.95 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8BFG", "evidence_id": "EV-PDB-8BFG-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "8BFG", "doi": "10.1016/j.ceca.2023.102831", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8BFG" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of human apo/Calmodulin G113R (G114R)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Haloalkane dehalogenase,Calmodulin-1,Haloalkane dehalogenase,Calmodulin-1,M13 peptide (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8B6Q", "evidence_id": "EV-PDB-8B6Q-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "8B6Q", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8B6Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of the haloalkane dehalogenase HaloTag7 with an insertion of Calmodulin-M13 fusion at position 154-156 that mimic the structure of CaProLa, an calcium gated protein labeling technology" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -80.0 }, "construct": { "description": "Calmodulin-1 (chains C,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VVD", "evidence_id": "EV-PDB-7VVD-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.134 }, "provenance": { "deposit_id": "7VVD", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VVD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q135P" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -153.15 }, "construct": { "description": "AlleyCat10 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VUT", "evidence_id": "EV-PDB-7VUT-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "7VUT", "doi": "10.1038/s41586-022-05278-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VUT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of AlleyCat10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MPD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -153.15 }, "construct": { "description": "AlleyCat (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VUR", "evidence_id": "EV-PDB-7VUR-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "7VUR", "doi": "10.1038/s41586-022-05278-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VUR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of AlleyCat9 with calcium but no inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -80.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7VUO", "evidence_id": "EV-PDB-7VUO-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.679 }, "provenance": { "deposit_id": "7VUO", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7VUO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F141L" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TCP", "evidence_id": "EV-PDB-7TCP-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.84 }, "provenance": { "deposit_id": "7TCP", "doi": "10.1038/s41467-022-31526-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TCP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Xenopus KCNQ1-CaM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "I0S" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7TCI", "evidence_id": "EV-PDB-7TCI-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "7TCI", "doi": "10.1038/s41467-022-31526-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7TCI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Xenopus KCNQ1-CaM in complex with ML277" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1LVX", "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XJI", "evidence_id": "EV-PDB-8XJI-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.91 }, "provenance": { "deposit_id": "8XJI", "doi": "10.1038/s41467-024-53490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XJI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of chimeric RyR complex with flubendiamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1LV1", "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XKH", "evidence_id": "EV-PDB-8XKH-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.87 }, "provenance": { "deposit_id": "8XKH", "doi": "10.1038/s41467-024-53490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XKH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of chimeric RyR Complex with tetraniliprole" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FAR" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. 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null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Nanchung-Inactive-Calmodulin in complex with Afidopyropen, EDTA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "6OU", "A1B32", "CA", "D39", "LBN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9NVQ", "evidence_id": "EV-PDB-9NVQ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.01 }, "provenance": { "deposit_id": "9NVQ", "doi": "10.1038/s41467-025-67287-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9NVQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Nanchung-Inactive-Calmodulin in complex with Afidopyropen and calcium" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "6OU", "D39", "LBN", "NCA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9NVP", "evidence_id": "EV-PDB-9NVP-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "9NVP", "doi": "10.1038/s41467-025-67287-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9NVP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Nanchung-Inactive-Calmodulin in complex with Nicotinamide, EDTA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "6OU", "CA", "D39", "LBN", "NCA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9NVO", "evidence_id": "EV-PDB-9NVO-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.49 }, "provenance": { "deposit_id": "9NVO", "doi": "10.1038/s41467-025-67287-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9NVO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Nanchung-Inactive-Calmodulin in complex with Nicotinamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "6OU", "CA", "D39", "LBN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9NVN", "evidence_id": "EV-PDB-9NVN-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.89 }, "provenance": { "deposit_id": "9NVN", "doi": "10.1038/s41467-025-67287-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9NVN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Nanchung-Inactive-Calmodulin in apo state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9MXD", "evidence_id": "EV-PDB-9MXD-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.17 }, "provenance": { "deposit_id": "9MXD", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9MXD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human E104A calmodulin:MLCK RM20 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9MVW", "evidence_id": "EV-PDB-9MVW-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.58 }, "provenance": { "deposit_id": "9MVW", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9MVW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of S101F calmodulin - CaM:RM20 analog complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KVO", "evidence_id": "EV-PDB-9KVO-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.14 }, "provenance": { "deposit_id": "9KVO", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KVO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D132E" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KVB", "evidence_id": "EV-PDB-9KVB-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "9KVB", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KVB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KV9", "evidence_id": "EV-PDB-9KV9-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.05 }, "provenance": { "deposit_id": "9KV9", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KV9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E141G-Ca" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KV1", "evidence_id": "EV-PDB-9KV1-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "9KV1", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KV1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E141G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KUU", "evidence_id": "EV-PDB-9KUU-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "9KUU", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KUU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D130G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KUO", "evidence_id": "EV-PDB-9KUO-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.13 }, "provenance": { "deposit_id": "9KUO", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KUO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q136P" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9KUI", "evidence_id": "EV-PDB-9KUI-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.68 }, "provenance": { "deposit_id": "9KUI", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9KUI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F142L" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "EDO", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calcium indicator GCaMP6s-BrUS-145,Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9K8X", "evidence_id": "EV-PDB-9K8X-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.05 }, "provenance": { "deposit_id": "9K8X", "doi": "10.3390/ijms252312493", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9K8X" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the calcium indicator GCaMP6s-BrUS-145 in calcium-bounded state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "KN9" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9JQI", "evidence_id": "EV-PDB-9JQI-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "9JQI", "doi": "10.1038/s42003-024-07331-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9JQI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of calmodulin in complex with KN93 (1:1 complex)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9J38", "evidence_id": "EV-PDB-9J38-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "9J38", "doi": "10.1073/pnas.2416738122", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9J38" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "human KCNQ5-CaM in apo state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1L3D" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9IXZ", "evidence_id": "EV-PDB-9IXZ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "9IXZ", "doi": "10.1038/s41589-024-01834-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9IXZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "human KCNQ2-CaM-Ebio3 Complex in the Presence of PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9HXW", "evidence_id": "EV-PDB-9HXW-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9HXW", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9HXW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (composite map)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Calmodulin-1 (chains C,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9EL6", "evidence_id": "EV-PDB-9EL6-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.25 }, "provenance": { "deposit_id": "9EL6", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9EL6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F90L" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "KVR", "L9R", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,D,E,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9E17", "evidence_id": "EV-PDB-9E17-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.45 }, "provenance": { "deposit_id": "9E17", "doi": "10.1073/pnas.2422082122", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9E17" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of RyR1 in the primed state in the presence of caffeine (reprocessed/reanalyzed from EMPIAR-10997, 7TZC, EMD-26205)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9D9Z", "evidence_id": "EV-PDB-9D9Z-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "9D9Z", "doi": "10.1038/s41586-025-09074-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9D9Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human UBR4-KCMF1-CaM E3 ligase complex (Silencing Factor of the Integrated stress response, SiFI)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CLR", "PCW", "Y01" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CUI", "evidence_id": "EV-PDB-9CUI-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.42 }, "provenance": { "deposit_id": "9CUI", "doi": "10.1016/j.str.2024.10.018", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CUI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1LWZ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XO1", "evidence_id": "EV-PDB-8XO1-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "8XO1", "doi": "10.1016/j.celrep.2025.116771", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XO1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM in complex with QO-83" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1LWZ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Potassium voltage-gated channel subfamily KQT member 2 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XO1", "evidence_id": "EV-PDB-8XO1-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "8XO1", "doi": "10.1016/j.celrep.2025.116771", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XO1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM in complex with QO-83" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XLH", "evidence_id": "EV-PDB-8XLH-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.62 }, "provenance": { "deposit_id": "8XLH", "doi": "10.1038/s41467-024-53490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XLH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of chimeric RyR-I4657M/G4819E" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8XLF", "evidence_id": "EV-PDB-8XLF-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.62 }, "provenance": { "deposit_id": "8XLF", "doi": "10.1038/s41467-024-53490-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8XLF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of chimeric RyR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "7Q0" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8X43", "evidence_id": "EV-PDB-8X43-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8X43", "doi": "10.1038/s41589-023-01515-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8X43" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9MF", "PIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C,E,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8W4U", "evidence_id": "EV-PDB-8W4U-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8W4U", "doi": "10.1038/s41467-023-42416-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8W4U" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "human KCNQ2-CaM in complex with PIP2 and HN37" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UXM", "evidence_id": "EV-PDB-8UXM-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.56 }, "provenance": { "deposit_id": "8UXM", "doi": "10.1038/s41467-024-51791-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UXM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UXL", "evidence_id": "EV-PDB-8UXL-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.12 }, "provenance": { "deposit_id": "8UXL", "doi": "10.1038/s41467-024-51791-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UXL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of PKA phosphorylated human RyR2-R420W in the primed state 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"cryoem", "title": "KCNQ1 with voltage sensor in the down conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 34.85 }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9PQI", "evidence_id": "EV-PDB-9PQI-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9PQI", "doi": "10.1016/j.jbc.2026.111131", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9PQI" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR Structure of Ca2+/Calmodulin bound to the GluN2A C0 domain of the NMDA receptor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9QWS", "evidence_id": "EV-PDB-9QWS-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9QWS", "doi": "10.1126/science.adv9309", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9QWS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (C-term dimer interface focused refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9QWU", "evidence_id": "EV-PDB-9QWU-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9QWU", "doi": "10.1126/science.adv9309", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9QWU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (CALM1 focused refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9QX0", "evidence_id": "EV-PDB-9QX0-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "9QX0", "doi": "10.1126/science.adv9309", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9QX0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (C-term focused refinement)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "K", "PT5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,E,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9U7F", "evidence_id": "EV-PDB-9U7F-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "9U7F", "doi": "10.1038/s41422-025-01182-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9U7F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-KCNE1-CaM complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "K", "PC1" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UJ4", "evidence_id": "EV-PDB-9UJ4-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.59 }, "provenance": { "deposit_id": "9UJ4", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UJ4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of human KCNQ1-CaM complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UPG", "evidence_id": "EV-PDB-9UPG-4", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.87 }, "provenance": { "deposit_id": "9UPG", "doi": "10.1038/s41467-025-64436-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UPG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human olfactory CNGA2/A4/B1 in CaM-bound closed state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,E,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VEC", "evidence_id": "EV-PDB-9VEC-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "9VEC", "doi": "10.1038/s41422-025-01152-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VEC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-KCNE1-CaM complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "PT5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,E,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VEI", "evidence_id": "EV-PDB-9VEI-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "9VEI", "doi": "10.1038/s41422-025-01152-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VEI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-KCNE1-CaM complex with PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "PT5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VEN", "evidence_id": "EV-PDB-9VEN-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "9VEN", "doi": "10.1038/s41422-025-01152-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VEN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-CaM-PIP2 complex with bent conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1ETX", "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VU9", "evidence_id": "EV-PDB-9VU9-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.34 }, "provenance": { "deposit_id": "9VU9", "doi": "10.1038/s41467-026-68475-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VU9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "channel D complex with 4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K", "POV" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VUA", "evidence_id": "EV-PDB-9VUA-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.23 }, "provenance": { "deposit_id": "9VUA", "doi": "10.1038/s41467-026-68475-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VUA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "channel A complex with 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1B92", "CA", "CLR", "K", "POV" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VUB", "evidence_id": "EV-PDB-9VUB-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.35 }, "provenance": { "deposit_id": "9VUB", "doi": "10.1038/s41467-026-68475-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VUB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "channel C complex with 3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K", "Y7Z" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VUC", "evidence_id": "EV-PDB-9VUC-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.96 }, "provenance": { "deposit_id": "9VUC", "doi": "10.1038/s41467-026-68475-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VUC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "channel B complex with 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1BBG", "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,E,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9WD8", "evidence_id": "EV-PDB-9WD8-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "9WD8", "doi": "10.1038/s41422-025-01152-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9WD8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-KCNE3-CaM complex with two PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9X5J", "evidence_id": "EV-PDB-9X5J-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.05 }, "provenance": { "deposit_id": "9X5J", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9X5J" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human KCNQ2/3 heteromer channel" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1EY8", "K", "PIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9X65", "evidence_id": "EV-PDB-9X65-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.19 }, "provenance": { "deposit_id": "9X65", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9X65" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1LVR", "PIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XB9", "evidence_id": "EV-PDB-9XB9-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9XB9", "doi": "10.1016/j.celrep.2025.116771", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XB9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM in complex with QO-58 and PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1LWZ", "PIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XED", "evidence_id": "EV-PDB-9XED-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "9XED", "doi": "10.1016/j.celrep.2025.116771", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XED" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human KCNQ2-CaM in complex with QO-83 and PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains D,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XTI", "evidence_id": "EV-PDB-9XTI-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.73 }, "provenance": { "deposit_id": "9XTI", "doi": "10.1093/procel/pwag036", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XTI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The focused structure of the C-terminal lobe of the human UBR4-KCMF1-Calmodulin complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains D,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9XTJ", "evidence_id": "EV-PDB-9XTJ-3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.89 }, "provenance": { "deposit_id": "9XTJ", "doi": "10.1093/procel/pwag036", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9XTJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Overall structure of the human UBR4-KCMF1-Calmodulin complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1B92", "CA", "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9Y5Q", "evidence_id": "EV-PDB-9Y5Q-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.73 }, "provenance": { "deposit_id": "9Y5Q", "doi": "10.1038/s41467-025-67232-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9Y5Q" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YDZ", "evidence_id": "EV-PDB-9YDZ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "9YDZ", "doi": "10.1038/s41467-025-67232-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YDZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo EM structure of KCa3.1_R355K_II/calmodulin channel in complex with rimtuzalcap" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YG4", "evidence_id": "EV-PDB-9YG4-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.38 }, "provenance": { "deposit_id": "9YG4", "doi": "10.1016/j.cell.2026.05.027", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YG4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VPS13A/Nt-CaM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YQP", "evidence_id": "EV-PDB-9YQP-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.1 }, "provenance": { "deposit_id": "9YQP", "doi": "10.1016/j.molcel.2026.06.028", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YQP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the VPS13C N-terminal region in complex with Calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YRM", "evidence_id": "EV-PDB-9YRM-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.75 }, "provenance": { "deposit_id": "9YRM", "doi": "10.1016/j.molcel.2026.06.028", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YRM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM Structure of VPS13 protein, 1-1390 from C. thermophilum, in complex with calmodulin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YRP", "evidence_id": "EV-PDB-9YRP-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.13 }, "provenance": { "deposit_id": "9YRP", "doi": "10.1016/j.molcel.2026.06.028", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YRP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Full-length human VPS13C in complex with calmodulin from the CryoEM composite map" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "43M", "ADP", "CA", "CFF", "U1C", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZN6", "evidence_id": "EV-PDB-9ZN6-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.58 }, "provenance": { "deposit_id": "9ZN6", "doi": "10.1038/s41467-026-76519-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZN6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene, ADP, 4-chloro-m-cresol, caffeine, and Mg2+" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP", "ATP", "MG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZN7", "evidence_id": "EV-PDB-9ZN7-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.23 }, "provenance": { "deposit_id": "9ZN7", "doi": "10.1038/s41467-026-76519-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZN7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking muscle fatigue)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ATP", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZN8", "evidence_id": "EV-PDB-9ZN8-1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.57 }, "provenance": { "deposit_id": "9ZN8", "doi": "10.1038/s41467-026-76519-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZN8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "43M", "ATP", "CA", "CFF", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZN9", "evidence_id": "EV-PDB-9ZN9-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "9ZN9", "doi": "10.1038/s41467-026-76519-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZN9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of rabbit RyR1 complexed with FKBP12.6, calmodulin, ATP, 4-chloro-m-cresol, and caffeine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "43M", "ADP", "CFF", "MG", "PLC", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZNA", "evidence_id": "EV-PDB-9ZNA-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.37 }, "provenance": { "deposit_id": "9ZNA", "doi": "10.1038/s41467-026-76519-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZNA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of rabbit RyR1 complexed with FKBP12.6, calmodulin, ADP, 4-chloro-m-cresol, caffeine, and Mg2+" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "43M", "ATP", "CA", "CFF", "CPS", "U1C", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZND", "evidence_id": "EV-PDB-9ZND-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.09 }, "provenance": { "deposit_id": "9ZND", "doi": "10.1038/s41467-026-76519-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZND" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in 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"source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of KCa3.1_I/calmodulin channel in complex with SKA31." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZPT", "evidence_id": "EV-PDB-9ZPT-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.39 }, "provenance": { "deposit_id": "9ZPT", "doi": "10.1016/j.str.2026.04.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": 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"10.1016/j.str.2026.04.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZRL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of KCa3.1_II/calmodulin channel in complex with SKA111." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1C3Q", "CA", "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZRQ", "evidence_id": "EV-PDB-9ZRQ-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "9ZRQ", "doi": "10.1016/j.str.2026.04.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ZRQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of KCa2.2/calmodulin channel in complex with SKA31." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1C3U", "CA", "K" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ZRR", "evidence_id": "EV-PDB-9ZRR-2", "mappings": [], "molecule_id": "P0DP23", 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"EV-PDB-9VEO-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "9VEO", "doi": "10.1038/s41422-025-01152-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VEO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-CaM-PIP2 complex with straight conformation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K", "PIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Calmodulin-1 (chains B,E,H,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UC8", "evidence_id": "EV-PDB-9UC8-2", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.36 }, "provenance": { "deposit_id": "9UC8", "doi": "10.1038/s41422-025-01182-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UC8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "structure of human KCNQ1-KCNE1-CaM complex with PIP2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=18323", "evidence_id": "EV-BMRB-18323", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr18323", "doi": "10.13018/BMR18323", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=18323" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution structure of the calcium-bound CaM C-terminal domain in a complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.0, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": 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Dmax 7 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 15.0 }, "construct": { "description": "Calmodulin-1 with Bifunctional hemolysin/adenylate cyclase", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDJ74/", "evidence_id": "EV-SASBDB-SASDJ74", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "radius_of_gyration", "uncertainty": 0.01, "unit": "nm", "value": 1.974 }, "provenance": { "deposit_id": "SASDJ74", "doi": "10.1002/advs.202003630", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDJ74/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Hepes, 150 mM NaCl, 2 mM CaCl2", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 7.2 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 288.0 }, "construct": { "description": "Calmodulin-1", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDNX3/", "evidence_id": "EV-SASBDB-SASDNX3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "radius_of_gyration", "uncertainty": 0.041, "unit": "nm", "value": 2.183 }, "provenance": { "deposit_id": "SASDNX3", "doi": "10.1186/s12915-022-01381-5", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDNX3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Hepes, 150 mM NaCl, 2 mM CaCl2", "environment": "in_vitro", "ions": [], "ligands": [ "partner: Calmidazolium" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 5.2 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 288.0 }, "construct": { "description": "Calmodulin-1 with Calmidazolium", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDNY3/", "evidence_id": "EV-SASBDB-SASDNY3", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "radius_of_gyration", "uncertainty": 0.039, "unit": "nm", "value": 1.689 }, "provenance": { "deposit_id": "SASDNY3", "doi": "10.1186/s12915-022-01381-5", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDNY3/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES pH 7.5, 150 mM NaCl, 5 mM CaCl2", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 6.88 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 10.0 }, "construct": { "description": "Calmodulin-1", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPD4/", "evidence_id": "EV-SASBDB-SASDPD4", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "radius_of_gyration", "uncertainty": 0.009, "unit": "nm", "value": 2.13 }, "provenance": { "deposit_id": "SASDPD4", "doi": "10.1016/j.jbc.2022.102495", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPD4/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "New insights into P2X7 receptor regulation: Ca2+-calmodulin and GDP bind to the soluble P2X7 ballast domain." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES pH 7.5, 150 mM NaCl, 5 mM CaCl2", "environment": "in_vitro", "ions": [], "ligands": [ "partner: P2X purinoceptor 7" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 13.53 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 10.0 }, "construct": { "description": "Calmodulin-1 with P2X purinoceptor 7", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPF4/", "evidence_id": "EV-SASBDB-SASDPF4", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "radius_of_gyration", "uncertainty": 0.014, "unit": "nm", "value": 3.24 }, "provenance": { "deposit_id": "SASDPF4", "doi": "10.1016/j.jbc.2022.102495", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPF4/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "New insights into P2X7 receptor regulation: Ca2+-calmodulin and GDP bind to the soluble P2X7 ballast domain." }, { "conditions": { "applied_force_pn": null, "buffer": "50 mM HEPES, 100 mM NaCl, 2 mM CaCl2, 1 mM TCEP", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 7 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 25.0 }, "construct": { "description": "Calmodulin-1", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPV6/", "evidence_id": "EV-SASBDB-SASDPV6", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "radius_of_gyration", "uncertainty": 0.069, "unit": "nm", "value": 2.178 }, "provenance": { "deposit_id": "SASDPV6", "doi": "10.1002/pro.4606", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPV6/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Binding by calmodulin is coupled to transient unfolding of the third FF domain of Prp40A." }, { "conditions": { "applied_force_pn": null, "buffer": "50 mM HEPES, 100 mM NaCl, 2 mM CaCl2, 1 mM TCEP", "environment": "in_vitro", "ions": [], "ligands": [ "partner: Pre-mRNA-processing factor 40 homolog A" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 8.7 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 25.0 }, "construct": { "description": "Calmodulin-1 with Pre-mRNA-processing factor 40 homolog A", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPX6/", "evidence_id": "EV-SASBDB-SASDPX6", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "radius_of_gyration", "uncertainty": 0.078, "unit": "nm", "value": 2.4 }, "provenance": { "deposit_id": "SASDPX6", "doi": "10.1002/pro.4606", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPX6/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Binding by calmodulin is coupled to transient unfolding of the third FF domain of Prp40A." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 76-85; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/34480001", "evidence_id": "EV-DISPROT-DP02013r002", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 10 }, "provenance": { "deposit_id": "DP02013r002", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP02013" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP02013: disorder, residues 76-85" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 76-85; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/34480001", "evidence_id": "EV-DISPROT-DP02013r003", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 10 }, "provenance": { "deposit_id": "DP02013r003", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP02013" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP02013: order to disorder, residues 76-85" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-149", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/P0DP23", "evidence_id": "EV-AFDB-AF-P0DP23-F1", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 85.25 }, "provenance": { "deposit_id": "AF-P0DP23-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/P0DP23" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-P0DP23-F1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "start 1CDL; Amber Parm99", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/A007P/overview", "evidence_id": "EV-MDDB-A007P", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A007P", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A007P/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 1CDL" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "start 2F3Y; Amber Parm99", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/A00EU/overview", "evidence_id": "EV-MDDB-A00EU", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A00EU", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A00EU/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 2F3Y" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "start 2F3Z; Amber Parm99", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/A0173/overview", "evidence_id": "EV-MDDB-A0173", "mappings": [], "molecule_id": "P0DP23", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A0173", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A0173/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 2F3Z" } ], "models": [ { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-1CLL-1" ], "file": "models/P0DP23/CaM-Ca4-extended.cif", "format": "mmCIF", "model_id": "CaM-Ca4-extended-cif", "molecule_id": "P0DP23", "provenance": { "deposit_id": "1CLL", "doi": "10.1016/0022-2836(92)90324-D", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/1CLL.cif" }, "state_id": "CaM-Ca4-extended" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-1CLL-1" ], "file": "models/P0DP23/CaM-Ca4-extended.pdb", "format": "PDB", "model_id": "CaM-Ca4-extended-pdb", "molecule_id": "P0DP23", "provenance": { "deposit_id": "1CLL", "doi": "10.1016/0022-2836(92)90324-D", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/1CLL.pdb" }, "state_id": "CaM-Ca4-extended" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-1CTR-1" ], "file": "models/P0DP23/CaM-Ca4-collapsed.cif", "format": "mmCIF", "model_id": "CaM-Ca4-collapsed-cif", "molecule_id": "P0DP23", "provenance": { "deposit_id": "1CTR", "doi": "10.1021/bi00255a006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/1CTR.cif" }, "state_id": "CaM-Ca4-collapsed" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-1CTR-1" ], "file": "models/P0DP23/CaM-Ca4-collapsed.pdb", "format": "PDB", "model_id": "CaM-Ca4-collapsed-pdb", "molecule_id": "P0DP23", "provenance": { "deposit_id": "1CTR", "doi": "10.1021/bi00255a006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/1CTR.pdb" }, "state_id": "CaM-Ca4-collapsed" } ], "molecule": { "components": [], "domains": [ { "end": 43, "name": "EF-hand 1", "start": 8 }, { "end": 79, "name": "EF-hand 2", "start": 44 }, { "end": 116, "name": "EF-hand 3", "start": 81 }, { "end": 149, "name": "EF-hand 4", "start": 117 } ], "gene": "CALM1", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P0DP23" }, "ligands": [ "Ca(2+)" ], "modifications": [ { "kind": "ptm", "name": "N-acetylalanine", "position": 2, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 22, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine; by CaMK4", "position": 45, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 82, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 95, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 100, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 102, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 111, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6,N6,N6-trimethyllysine; alternate", "position": 116, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-methyllysine; alternate", "position": 116, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 139, "source": "UniProtKB" } ], "molecule_id": "P0DP23", "molecule_type": "protein", "name": "Calmodulin-1", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P0DP23", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0DP23/entry" }, "sequence": "MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK", "sequence_length": 149 }, "molecule_id": "P0DP23", "states": [ { "assumptions": [], "basis": "observed", "description": "Four Ca2+ bound, two lobes separated by the central helix, as in 1CLL.", "family_label": null, "molecule_id": "P0DP23", "name": "Ca2+-saturated, extended", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P0DP23.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P0DP23.yaml" }, "representative_model": "CaM-Ca4-extended-cif", "secondary_structure": null, "state_id": "CaM-Ca4-extended", "status": "draft" }, { "assumptions": [], "basis": "observed", "description": "Four Ca2+ bound with trifluoperazine; 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