{ "conflicts": [], "coverage": { "cells": { "SH3-native": { "af_prediction": 0, "cryoem": 0, "integrative": 0, "md": 0, "nmr_dynamics": 0, "nmr_shifts": 0, "nmr_structure": 11, "saxs_sans": 0, "xray": 38 }, "SH3-unfolded": { "af_prediction": 0, "cryoem": 0, "integrative": 0, "md": 0, "nmr_dynamics": 0, "nmr_shifts": 0, "nmr_structure": 0, "saxs_sans": 0, "xray": 0 } }, "data_levels": { "SH3-native": { "nmr_structure": "processed", "xray": "processed" }, "SH3-unfolded": {} }, "single_method_states": [], "states": [ "SH3-native", "SH3-unfolded" ], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_dynamics", "nmr_shifts", "saxs_sans", "integrative", "af_prediction", "md" ], "unmapped_evidence": 28 }, "curation": { "as_of": "2026-10-19", "curator": "draft (unreviewed)", "file": "P07751.yaml", "status": "draft" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3M0S", "evidence_id": "EV-PDB-3M0S-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "3M0S", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3M0S" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 7" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FMT", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, non-erythrocytic 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5IHN", "evidence_id": "EV-PDB-5IHN-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "5IHN", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5IHN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the alpha spectrin SH3 domain mutant N47G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "PRO", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, non-erythrocytic 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5IHK", "evidence_id": "EV-PDB-5IHK-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "5IHK", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5IHK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the alpha spectrin SH3 domain mutant N47A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PEG", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, non-erythrocytic 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5IHI", "evidence_id": "EV-PDB-5IHI-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.45 }, "provenance": { "deposit_id": "5IHI", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5IHI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the alpha spectrin SH3 domain double mutant V46G-D48G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4F17", "evidence_id": "EV-PDB-4F17-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.55 }, "provenance": { "deposit_id": "4F17", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4F17" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the alpha spectrin SH3 domain at pH 9" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4F16", "evidence_id": "EV-PDB-4F16-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.93 }, "provenance": { "deposit_id": "4F16", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4F16" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the alpha spectrin SH3 domain at pH 5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3NGP", "evidence_id": "EV-PDB-3NGP-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.084 }, "provenance": { "deposit_id": "3NGP", "doi": "10.1107/S1744309110030095", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3NGP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "High resolution structure of alpha-spectrin SH3 domain mutant with a redesigned core" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FMT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3M0U", "evidence_id": "EV-PDB-3M0U-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.1 }, "provenance": { "deposit_id": "3M0U", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3M0U" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Hexagonal crystal obtained in sodium formate at pH 6.5." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3M0T", "evidence_id": "EV-PDB-3M0T-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "3M0T", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3M0T" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 9." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3M0R", "evidence_id": "EV-PDB-3M0R-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.1 }, "provenance": { "deposit_id": "3M0R", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3M0R" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 6." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3M0Q", "evidence_id": "EV-PDB-3M0Q-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "3M0Q", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3M0Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 5." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3M0P", "evidence_id": "EV-PDB-3M0P-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "3M0P", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3M0P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 4." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3I9Q", "evidence_id": "EV-PDB-3I9Q-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.45 }, "provenance": { "deposit_id": "3I9Q", "doi": "10.1107/S0907444909038037", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3I9Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": 25.85 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2ROT", "evidence_id": "EV-PDB-2ROT-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2ROT", "doi": "10.1016/j.bbapap.2009.08.021", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2ROT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of chimeric variant of SH3 domain- SHH" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2RMO", "evidence_id": "EV-PDB-2RMO-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2RMO", "doi": "10.1134/S1068162008050075", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2RMO" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of alpha-spectrin_SH3-bergerac from Chicken" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2OAW", "evidence_id": "EV-PDB-2OAW-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2OAW", "doi": "10.1016/j.bpc.2008.10.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2OAW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SHH variant of \"Bergerac\" chimera of spectrin SH3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2NUZ", "evidence_id": "EV-PDB-2NUZ-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "2NUZ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2NUZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "crystal structure of alpha spectrin SH3 domain measured at room temperature" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides 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"in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "11-mer peptide,Spectrin alpha chain, non-erythrocytic 1,Spectrin alpha chain, non-erythrocytic 1 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2KXD", "evidence_id": "EV-PDB-2KXD-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2KXD", "doi": "10.1134/S0026893310060129", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2KXD" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "The structure of SH3-F2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2KR3", "evidence_id": "EV-PDB-2KR3-1", "mappings": [], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2KR3", "doi": "10.1134/S1068162010040059", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2KR3" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of SHA-D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": 30.0 }, "construct": { "description": "Spectrin alpha chain, brain and P41 peptide chimera (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2JMC", "evidence_id": "EV-PDB-2JMC-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2JMC", "doi": "10.1016/j.febslet.2007.01.032", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2JMC" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Chimer between Spc-SH3 and P41" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2JMA", "evidence_id": "EV-PDB-2JMA-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2JMA", "doi": "10.1186/1472-6807-7-22", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2JMA" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "R21A Spc-SH3:P41 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2JM9", "evidence_id": "EV-PDB-2JM9-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2JM9", "doi": "10.1186/1472-6807-7-22", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2JM9" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "R21A Spc-SH3 bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2JM8", "evidence_id": "EV-PDB-2JM8-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin 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"data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2F2X", "evidence_id": "EV-PDB-2F2X-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2F2X", "doi": "10.1002/prot.21284", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2F2X" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "alpha-spectrin SH3 domain R21G mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2F2W", "evidence_id": "EV-PDB-2F2W-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "2F2W", "doi": "10.1002/prot.21284", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2F2W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "alpha-spectrin SH3 domain R21A mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FMT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2F2V", "evidence_id": "EV-PDB-2F2V-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": 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"processed", "data_link": "https://www.rcsb.org/structure/2CDT", "evidence_id": "EV-PDB-2CDT-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.54 }, "provenance": { "deposit_id": "2CDT", "doi": "10.1002/PROT.21284", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2CDT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "alpha-SPECTRIN SH3 DOMAIN A56S MUTANT" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "SPECTRIN ALPHA CHAIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1UUE", "evidence_id": "EV-PDB-1UUE-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1UUE", "doi": "10.1073/PNAS.0304180101", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1UUE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "a-SPECTRIN SH3 DOMAIN (V44T, D48G MUTANT)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K", "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1U5P", "evidence_id": "EV-PDB-1U5P-1", "mappings": [], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "1U5P", "doi": "10.1016/j.jmb.2004.09.019", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1U5P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Repeats 15 and 16 of Chicken Brain Alpha Spectrin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1U4Q", "evidence_id": "EV-PDB-1U4Q-1", "mappings": [], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "1U4Q", "doi": "10.1016/j.jmb.2004.09.019", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1U4Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Repeats 15, 16 and 17 of Chicken Brain Alpha Spectrin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "AZI" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Spectrin alpha chain, brain (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1U06", "evidence_id": "EV-PDB-1U06-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 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{ "description": "ALPHA-SPECTRIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1TUD", "evidence_id": "EV-PDB-1TUD-1", "mappings": [], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.77 }, "provenance": { "deposit_id": "1TUD", "doi": "10.1006/jmbi.1994.0171", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1TUD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "ALPHA-SPECTRIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1TUC", "evidence_id": "EV-PDB-1TUC-1", "mappings": [], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.02 }, "provenance": { "deposit_id": "1TUC", "doi": "10.1006/jmbi.1994.0171", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1TUC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT S19-P20" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "ALPHA-SPECTRIN SH3 DOMAIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SHG", "evidence_id": "EV-PDB-1SHG-1", "mappings": [ { "confidence": "high", "justification": "Representative native structure; title and UniProt mapping checked against RCSB.", "rule": "curator_assignment", "state_id": "SH3-native", "who": "curator:draft (unreviewed)" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "1SHG", "doi": "10.1038/359851a0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SHG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF A SRC-HOMOLOGY 3 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null, "source_kind": "deposit", "technique": "xray", "title": "Alpha-spectrin Src Homology 3 domain, N47G mutant in the distal loop." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": 13.85 }, "construct": { "description": "ALPHA SPECTRIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1PWT", "evidence_id": "EV-PDB-1PWT-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], 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null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": 6.85 }, "construct": { "description": "SPECTRIN ALPHA CHAIN, BRAIN (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1M8M", "evidence_id": "EV-PDB-1M8M-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1M8M", "doi": "10.1038/nature01070", 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"labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1H8K", "evidence_id": "EV-PDB-1H8K-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "1H8K", "doi": "10.1038/NSB799", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1H8K" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V53I, V58L MUTANT" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "SPECTRIN ALPHA CHAIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1G2B", "evidence_id": "EV-PDB-1G2B-1", "mappings": [], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.12 }, "provenance": { "deposit_id": "1G2B", "doi": "10.1107/S090744490001581X", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1G2B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "SPECTRIN ALPHA CHAIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1E7O", "evidence_id": "EV-PDB-1E7O-1", "mappings": [ { "confidence": "medium", "justification": "Experimental structure titled as the SH3 domain; the UniProt entry covers the whole spectrin chain, so other repeats are excluded by title.", "rule": "sh3-structures-native", "state_id": "SH3-native", "who": "rule:sh3-structures-native" } ], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { 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"applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -165.15 }, "construct": { "description": "PROTEIN (ALPHA SPECTRIN) (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1CUN", "evidence_id": "EV-PDB-1CUN-1", "mappings": [], "molecule_id": "P07751", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "1CUN", "doi": "10.1016/S0092-8674(00)81980-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1CUN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF 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"conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 3.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "BMRB data: 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=7306", "evidence_id": "EV-BMRB-7306", "mappings": [], "molecule_id": "P07751", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr7306", "doi": "10.13018/BMR7306", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=7306" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "R21A Spc-SH3 bound" }, { "conditions": { "applied_force_pn": null, "buffer": "10 mM citric acid, 150 mM 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"construct": { "description": "start 1PWT; Amber Parm99", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/A00W4/overview", "evidence_id": "EV-MDDB-A00W4", "mappings": [], "molecule_id": "P07751", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A00W4", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A00W4/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 1PWT" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "start 1SHG; Amber Parm99", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/A010H/overview", "evidence_id": "EV-MDDB-A010H", "mappings": [], "molecule_id": "P07751", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A010H", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A010H/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 1SHG" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "start 1TUC; Amber Parm99", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/A012Z/overview", "evidence_id": "EV-MDDB-A012Z", "mappings": [], "molecule_id": "P07751", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A012Z", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A012Z/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 1TUC" } ], "models": [ { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-1SHG-1" ], "file": "models/P07751/SH3-native.cif", "format": "mmCIF", "model_id": "SH3-native-cif", "molecule_id": "P07751", "provenance": { "deposit_id": "1SHG", "doi": "10.1038/359851a0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/1SHG.cif" }, "state_id": "SH3-native" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-1SHG-1" ], "file": "models/P07751/SH3-native.pdb", "format": "PDB", "model_id": "SH3-native-pdb", "molecule_id": "P07751", "provenance": { "deposit_id": "1SHG", "doi": "10.1038/359851a0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/1SHG.pdb" }, "state_id": "SH3-native" } ], "molecule": { "components": [], "domains": [ { "end": 1026, "name": "SH3", "start": 967 }, { "end": 2363, "name": "EF-hand 1", "start": 2328 }, { "end": 2406, "name": "EF-hand 2", "start": 2371 }, { "end": 2444, "name": "EF-hand 3", "start": 2409 } ], "gene": "SPTAN1", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P07751" }, "ligands": [ "Ca(2+)" ], "modifications": [ { "kind": "ptm", "name": "Phosphotyrosine", "position": 1176, "source": "UniProtKB" } ], "molecule_id": "P07751", "molecule_type": "protein", "name": "Spectrin alpha chain, non-erythrocytic 1", "organism": { "name": "Gallus gallus", "taxon_id": 9031 }, "provenance": { "deposit_id": "P07751", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07751/entry" }, "sequence": 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"sequence_length": 2477 }, "molecule_id": "P07751", "states": [ { "assumptions": [], "basis": "observed", "description": "Native fold of the alpha-spectrin SH3 domain, as in 1SHG.", "family_label": null, "molecule_id": "P07751", "name": "native fold", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P07751.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P07751.yaml" }, "representative_model": "SH3-native-cif", "secondary_structure": null, "state_id": "SH3-native", "status": "draft" }, { "assumptions": [ "Treated as a single ensemble; residual structure and intermediates are not resolved.", "Defined by indirect measurements (denaturation, NMR of denatured samples, force spectroscopy); no model is exported." ], "basis": "inferred", "description": "Unfolded ensemble reached by denaturant, temperature or force. No observed structure.", "family_label": null, "molecule_id": "P07751", "name": "unfolded", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P07751.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P07751.yaml" }, "representative_model": null, "secondary_structure": null, "state_id": "SH3-unfolded", "status": "draft" } ], "transitions": [] }