{ "conflicts": [], "coverage": { "cells": { "B2AR-active": { "af_prediction": 0, "cd": 0, "cryoem": 4, "force_spectroscopy": 0, "nmr_shifts": 0, "nmr_structure": 0, "saxs_sans": 0, "xray": 2 }, "B2AR-inactive": { "af_prediction": 0, "cd": 0, "cryoem": 1, "force_spectroscopy": 0, "nmr_shifts": 0, "nmr_structure": 0, "saxs_sans": 0, "xray": 11 } }, "data_levels": { "B2AR-active": { "cryoem": "processed", "xray": "processed" }, "B2AR-inactive": { "cryoem": "processed", "xray": "processed" } }, "single_method_states": [], "states": [ "B2AR-inactive", "B2AR-active" ], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "saxs_sans", "cd", "force_spectroscopy", "af_prediction" ], "unmapped_evidence": 139 }, "curation": { "as_of": "2026-10-19", "curator": "draft (unreviewed)", "file": "P07550.yaml", "status": "draft" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; 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oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -195.15 }, "construct": { "description": "Endolysin,Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SN6", "evidence_id": "EV-PDB-3SN6-4", "mappings": [ { "confidence": "high", "justification": "Receptor-Gs complex.", "rule": "curator_assignment", "state_id": "B2AR-active", "who": "curator:draft (unreviewed)" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "3SN6", "doi": "10.1038/nature10361", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SN6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the beta2 adrenergic receptor-Gs protein complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CAU" ], "notes": "Entry-level ligand list; 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oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -195.15 }, "construct": { "description": "Lysozyme, Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LDO", "evidence_id": "EV-PDB-4LDO-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "4LDO", "doi": "10.1038/nature12572", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LDO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "35V", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.8, "salt_mM": null, "temperature_c": -195.15 }, "construct": { "description": "Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4QKX", "evidence_id": "EV-PDB-4QKX-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "4QKX", "doi": "10.1073/pnas.1410415111", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4QKX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "beta 2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6KR8", "evidence_id": "EV-PDB-6KR8-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6KR8", "doi": "10.1038/s41589-019-0457-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6KR8" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of the beta2 adrenergic receptor in the full agonist bound state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "H98" ], "notes": "Entry-level ligand list; 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oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE8", "evidence_id": "EV-PDB-8GE8-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GE8", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#9 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE7", "evidence_id": "EV-PDB-8GE7-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GE7", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#8 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE6", "evidence_id": "EV-PDB-8GE6-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GE6", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#7 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE5", "evidence_id": "EV-PDB-8GE5-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8GE5", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#6 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE4", "evidence_id": "EV-PDB-8GE4-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GE4", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#5 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE3", "evidence_id": "EV-PDB-8GE3-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GE3", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#4 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE2", "evidence_id": "EV-PDB-8GE2-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GE2", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#3 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE1", "evidence_id": "EV-PDB-8GE1-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GE1", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#2 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GDZ", "evidence_id": "EV-PDB-8GDZ-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GDZ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GDZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#1 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Endolysin,Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XKA", "evidence_id": "EV-PDB-7XKA-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "7XKA", "doi": "10.1038/s41467-023-37808-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XKA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of human beta2 adrenergic receptor bound to constrained epinephrine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GJ6", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Endolysin,Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XK9", "evidence_id": "EV-PDB-7XK9-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7XK9", "doi": "10.1038/s41467-023-37808-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XK9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of human beta2 adrenergic receptor bound to constrained isoproterenol" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "5FW" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DHR", "evidence_id": "EV-PDB-7DHR-5", "mappings": [ { "confidence": "medium", "justification": "Title describes a G protein complex or a nanobody-stabilised active state.", "rule": "b2ar-active-title", "state_id": "B2AR-active", "who": "rule:b2ar-active-title" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "7DHR", "doi": "10.1093/nsr/nwaa284", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DHR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-Gs protein complex." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "68H" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DHI", "evidence_id": "EV-PDB-7DHI-5", "mappings": [ { "confidence": "medium", "justification": "Title describes a G protein complex or a nanobody-stabilised active state.", "rule": "b2ar-active-title", "state_id": "B2AR-active", "who": "rule:b2ar-active-title" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.26 }, "provenance": { "deposit_id": "7DHI", "doi": "10.1093/nsr/nwaa284", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DHI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the partial agonist salbutamol-bound beta2 adrenergic receptor-Gs protein complex." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "OLA", "OLC", "SO4", "TIM" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PS6", "evidence_id": "EV-PDB-6PS6-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "6PS6", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PS6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Timolol to Timolol." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "OLA", "OLC", "SNP", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PS5", "evidence_id": "EV-PDB-6PS5-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "6PS5", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PS5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Timolol to Propranolol." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "JRZ", "OLA", "OLC", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PS4", "evidence_id": "EV-PDB-6PS4-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "6PS4", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PS4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Timolol to ICI-118551." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "CVD", "OLA", "OLC", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PS3", "evidence_id": "EV-PDB-6PS3-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "6PS3", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PS3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Timolol to Carvedilol." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "JTZ", "OLA", "OLB", "OLC", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PS2", "evidence_id": "EV-PDB-6PS2-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "6PS2", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PS2" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Timolol to Alprenolol." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "OLA", "OLC", "SO4", "TIM" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PS1", "evidence_id": "EV-PDB-6PS1-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "6PS1", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PS1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Alprenolol to Timolol." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CAU", "CLR", "OLA", "OLC", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PS0", "evidence_id": "EV-PDB-6PS0-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "6PS0", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PS0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Alprenolol to Carazolol." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "JTZ", "OLA", "OLC", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Fusion protein of Beta-2 adrenergic receptor and T4 Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6PRZ", "evidence_id": "EV-PDB-6PRZ-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "6PRZ", "doi": "10.1107/S2052252519013137", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6PRZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XFEL beta2 AR structure by ligand exchange from Alprenolol to Alprenolol." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "JTZ", "M3J" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Beta-2 adrenergic receptor,Lysozyme,Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6OBA", "evidence_id": "EV-PDB-6OBA-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "6OBA", "doi": "10.1038/s41589-020-0549-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6OBA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The beta2 adrenergic receptor bound to a negative allosteric modulator" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P0G" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Endolysin,Beta-2 adrenergic receptor chimera (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6NI3", "evidence_id": "EV-PDB-6NI3-4", "mappings": [ { "confidence": "medium", "justification": "Title describes a G protein complex or a nanobody-stabilised active state.", "rule": "b2ar-active-title", "state_id": "B2AR-active", "who": "rule:b2ar-active-title" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "6NI3", "doi": "10.1038/s41594-019-0330-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6NI3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "1WV", "KBY", "P0G" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N48", "evidence_id": "EV-PDB-6N48-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "6N48", "doi": "10.1126/science.aaw8981", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N48" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "HTO", "K5Y", "MG", "NI", "OLA", "OLC", "P33" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -196.15 }, "construct": { "description": "Endolysin, Beta-2 adrenergic receptor chimera (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6MXT", "evidence_id": "EV-PDB-6MXT-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95934213525 }, "provenance": { "deposit_id": "6MXT", "doi": "10.1038/s41589-018-0145-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6MXT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P0G" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6E67", "evidence_id": "EV-PDB-6E67-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "6E67", "doi": "10.1016/j.cell.2019.04.021", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6E67" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of beta2 adrenergic receptor fused to a Gs peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "8VS", "ACM", "BU1", "CAU", "CLR", "EPE" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -195.15 }, "construct": { "description": "Chimera protein of Beta-2 adrenergic receptor and Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5X7D", "evidence_id": "EV-PDB-5X7D-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.703 }, "provenance": { "deposit_id": "5X7D", "doi": "10.1038/nature23652", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5X7D" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CAU", "CLR" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Endolysin,Beta-2 adrenergic receptor (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5JQH", "evidence_id": "EV-PDB-5JQH-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "5JQH", "doi": "10.1038/nature18636", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5JQH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "12P", "ACM", "BU1", "CAU", "CLR", "PLM", "SO4", "branched: alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin,Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5D6L", "evidence_id": "EV-PDB-5D6L-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "5D6L", "doi": "10.1038/nprot.2017.057", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5D6L" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "beta2AR-T4L - CIM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACM", "BU1", "CAU", "CLR", "PLM", "SO4", "branched: alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin,Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5D5B", "evidence_id": "EV-PDB-5D5B-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "5D5B", "doi": "10.1107/S2059798315021683", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5D5B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "12P", "ACM", "BU1", "CAU", "CLR", "PLM", "SO4", "branched: alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin,Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5D5A", "evidence_id": "EV-PDB-5D5A-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4826 }, "provenance": { "deposit_id": "5D5A", "doi": "10.1107/S2059798315021683", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5D5A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "ERC", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.7, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Fusion protein Beta-2 adrenergic receptor/Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PDS", "evidence_id": "EV-PDB-3PDS-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "3PDS", "doi": "10.1038/nature09665", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PDS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Irreversible Agonist-Beta2 Adrenoceptor Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P0G" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -195.15 }, "construct": { "description": "Beta-2 adrenergic receptor, Lysozyme (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3P0G", "evidence_id": "EV-PDB-3P0G-1", "mappings": [ { "confidence": "high", "justification": "Title: nanobody-stabilized active state.", "rule": "curator_assignment", "state_id": "B2AR-active", "who": "curator:draft (unreviewed)" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "3P0G", "doi": "10.1038/nature09648", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3P0G" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of a nanobody-stabilized active state of the beta2 adrenoceptor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Beta-2 adrenergic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2R4R", "evidence_id": "EV-PDB-2R4R-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "2R4R", "doi": "10.1038/nature06325", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2R4R" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the human beta2 adrenoceptor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.24, "salt_mM": null, "temperature_c": -158.15 }, "construct": { "description": "EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1GQ4", "evidence_id": "EV-PDB-1GQ4-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "1GQ4", "doi": "10.1074/JBC.M201507200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1GQ4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "STRUCTURAL DETERMINANTS OF THE NHERF INTERACTION WITH BETA2AR AND PDGFR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEA", "evidence_id": "EV-PDB-8GEA-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GEA", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#11 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEB", "evidence_id": "EV-PDB-8GEB-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8GEB", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#12 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEC", "evidence_id": "EV-PDB-8GEC-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GEC", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#13 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GED", "evidence_id": "EV-PDB-8GED-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GED", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GED" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#14 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEE", "evidence_id": "EV-PDB-8GEE-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "8GEE", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#15 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEF", "evidence_id": "EV-PDB-8GEF-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "8GEF", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#16 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEH", "evidence_id": "EV-PDB-8GEH-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "8GEH", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#18 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEI", "evidence_id": "EV-PDB-8GEI-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.1 }, "provenance": { "deposit_id": "8GEI", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#19 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GFV", "evidence_id": "EV-PDB-8GFV-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8GFV", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GFV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GFW", "evidence_id": "EV-PDB-8GFW-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8GFW", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GFW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GFX", "evidence_id": "EV-PDB-8GFX-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8GFX", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GFX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #3 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GFY", "evidence_id": "EV-PDB-8GFY-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8GFY", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GFY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #4 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GFZ", "evidence_id": "EV-PDB-8GFZ-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8GFZ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GFZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG0", "evidence_id": "EV-PDB-8GG0-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8GG0", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG2", "evidence_id": "EV-PDB-8GG2-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8GG2", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #8 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG3", "evidence_id": "EV-PDB-8GG3-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8GG3", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #9 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG4", "evidence_id": "EV-PDB-8GG4-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8GG4", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #10 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG5", "evidence_id": "EV-PDB-8GG5-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8GG5", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #11 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG6", "evidence_id": "EV-PDB-8GG6-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GG6", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #12 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG7", "evidence_id": "EV-PDB-8GG7-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GG7", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #13 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG8", "evidence_id": "EV-PDB-8GG8-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GG8", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #14 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG9", "evidence_id": "EV-PDB-8GG9-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GG9", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGA", "evidence_id": "EV-PDB-8GGA-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGA", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGA" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #16 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGB", "evidence_id": "EV-PDB-8GGB-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGB", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #17 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGE", "evidence_id": "EV-PDB-8GGE-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGE", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #19 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGF", "evidence_id": "EV-PDB-8GGF-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8GGF", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #20 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGI", "evidence_id": "EV-PDB-8GGI-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGI", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGJ", "evidence_id": "EV-PDB-8GGJ-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGJ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGK", "evidence_id": "EV-PDB-8GGK-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GGK", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #3 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGM", "evidence_id": "EV-PDB-8GGM-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8GGM", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGO", "evidence_id": "EV-PDB-8GGO-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8GGO", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGP", "evidence_id": "EV-PDB-8GGP-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8GGP", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #8 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGQ", "evidence_id": "EV-PDB-8GGQ-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GGQ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #9 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGR", "evidence_id": "EV-PDB-8GGR-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GGR", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #10 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGS", "evidence_id": "EV-PDB-8GGS-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGS", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #11 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGT", "evidence_id": "EV-PDB-8GGT-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGT", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #12 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGU", "evidence_id": "EV-PDB-8GGU-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GGU", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #13 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGW", "evidence_id": "EV-PDB-8GGW-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8GGW", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGX", "evidence_id": "EV-PDB-8GGX-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8GGX", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #16 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GH0", "evidence_id": "EV-PDB-8GH0-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "8GH0", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GH0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #19 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGZ", "evidence_id": "EV-PDB-8GGZ-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "8GGZ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #18 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGY", "evidence_id": "EV-PDB-8GGY-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "8GGY", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #17 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGV", "evidence_id": "EV-PDB-8GGV-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GGV", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #14 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGN", "evidence_id": "EV-PDB-8GGN-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8GGN", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGL", "evidence_id": "EV-PDB-8GGL-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8GGL", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #4 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GGC", "evidence_id": "EV-PDB-8GGC-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8GGC", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GGC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #18 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GG1", "evidence_id": "EV-PDB-8GG1-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8GG1", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GG1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #7 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEJ", "evidence_id": "EV-PDB-8GEJ-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.2 }, "provenance": { "deposit_id": "8GEJ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#20 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GEG", "evidence_id": "EV-PDB-8GEG-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "8GEG", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GEG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#17 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GE9", "evidence_id": "EV-PDB-8GE9-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8GE9", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GE9" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#10 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "H98" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Soluble cytochrome b562 (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JJ8", "evidence_id": "EV-PDB-8JJ8-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8JJ8", "doi": "10.1038/s41589-023-01389-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JJ8" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with a partial agonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "DZQ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Soluble cytochrome b562 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JJL", "evidence_id": "EV-PDB-8JJL-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8JJL", "doi": "10.1038/s41589-023-01389-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JJL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "cryo-EM structure of the beta2-AR-mBRIL/1b3 Fab/Glue complex with a full agonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "JTZ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Beta-2 adrenergic receptor,Soluble cytochrome b562 (chains F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8JJO", "evidence_id": "EV-PDB-8JJO-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8JJO", "doi": "10.1038/s41589-023-01389-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8JJO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "WV8" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Soluble cytochrome b562,Beta-2 adrenergic receptor,Trace amine-associated receptor 1 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UHB", "evidence_id": "EV-PDB-8UHB-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.35 }, "provenance": { "deposit_id": "8UHB", "doi": "10.1038/s41467-023-44601-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UHB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNL", "evidence_id": "EV-PDB-8UNL-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8UNL", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class A)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNM", "evidence_id": "EV-PDB-8UNM-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8UNM", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class B)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNN", "evidence_id": "EV-PDB-8UNN-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8UNN", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNO", "evidence_id": "EV-PDB-8UNO-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8UNO", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class D)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNP", "evidence_id": "EV-PDB-8UNP-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8UNP", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class E)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNQ", "evidence_id": "EV-PDB-8UNQ-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8UNQ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class F)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNR", "evidence_id": "EV-PDB-8UNR-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8UNR", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class G)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNS", "evidence_id": "EV-PDB-8UNS-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8UNS", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class H)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNT", "evidence_id": "EV-PDB-8UNT-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8UNT", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNU", "evidence_id": "EV-PDB-8UNU-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8UNU", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class J)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNV", "evidence_id": "EV-PDB-8UNV-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8UNV", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class K)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNW", "evidence_id": "EV-PDB-8UNW-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "8UNW", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class L)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNX", "evidence_id": "EV-PDB-8UNX-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8UNX", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class M)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNY", "evidence_id": "EV-PDB-8UNY-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8UNY", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UNZ", "evidence_id": "EV-PDB-8UNZ-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "8UNZ", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UNZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class O)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UO0", "evidence_id": "EV-PDB-8UO0-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8UO0", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UO0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class P)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UO1", "evidence_id": "EV-PDB-8UO1-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8UO1", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UO1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class Q)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UO2", "evidence_id": "EV-PDB-8UO2-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "8UO2", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UO2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class R)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UO3", "evidence_id": "EV-PDB-8UO3-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8UO3", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UO3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class S)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I", "GTP", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UO4", "evidence_id": "EV-PDB-8UO4-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "8UO4", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8UO4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class T)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1AE2", "AV0" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8W1V", "evidence_id": "EV-PDB-8W1V-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8W1V", "doi": "10.1021/acs.jmedchem.4c00578", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8W1V" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The beta2 adrenergic receptor bound to a bitopic ligand" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein) (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZBE", "evidence_id": "EV-PDB-8ZBE-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.24 }, "provenance": { "deposit_id": "8ZBE", "doi": "10.1038/s41401-024-01314-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ZBE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "cryo-EM structure of the octreotide-bound SSTR5-Gi complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein) (chains G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZCJ", "evidence_id": "EV-PDB-8ZCJ-5", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.09 }, "provenance": { "deposit_id": "8ZCJ", "doi": "10.1038/s41401-024-01314-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ZCJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1D9A" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,C3a anaphylatoxin chemotactic receptor (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8ZWG", "evidence_id": "EV-PDB-8ZWG-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.87 }, "provenance": { "deposit_id": "8ZWG", "doi": "10.1038/s41421-024-00765-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8ZWG" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "cryoEM structure of JR14a bound C3aR-Gi complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1ASM", "CLR", "KBY" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BUY", "evidence_id": "EV-PDB-9BUY-5", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "9BUY", "doi": "10.1126/sciadv.adq3971", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BUY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of the LM189-Bound beta2AR-Gi Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "E5E", "FK5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CHU", "evidence_id": "EV-PDB-9CHU-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.49 }, "provenance": { "deposit_id": "9CHU", "doi": "10.1073/pnas.2414544121", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CHU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of calcineurin fused beta2 adrenergic receptor in norepinephrine bound inactive state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FK5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CHV", "evidence_id": "EV-PDB-9CHV-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.95 }, "provenance": { "deposit_id": "9CHV", "doi": "10.1073/pnas.2414544121", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CHV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in apo state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CAU", "FK5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Calcineurin subunit B type 1 (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CHX", "evidence_id": "EV-PDB-9CHX-1", "mappings": [ { "confidence": "medium", "justification": "Carazolol (CAU) or timolol (TIM) bound: inverse agonist or antagonist structures are inactive.", "rule": "b2ar-inverse-agonist", "state_id": "B2AR-inactive", "who": "rule:b2ar-inverse-agonist" } ], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "9CHX", "doi": "10.1073/pnas.2414544121", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CHX" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1IZU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,D(1A) dopamine receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9I52", "evidence_id": "EV-PDB-9I52-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "9I52", "doi": "10.1021/acs.jmedchem.5c00294", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9I52" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dopamine 1 receptor:GaS complex bound to 19B" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1IZV" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,D(1A) dopamine receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9I54", "evidence_id": "EV-PDB-9I54-4", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.72 }, "provenance": { "deposit_id": "9I54", "doi": "10.1021/acs.jmedchem.5c00294", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9I54" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Dopamine 1 receptor:GaS complex bound to 24" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "DR7", "P0G" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9L8L", "evidence_id": "EV-PDB-9L8L-5", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.22 }, "provenance": { "deposit_id": "9L8L", "doi": "10.1016/j.cell.2025.12.023", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9L8L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of GPCR megacomplex bound to agonists" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "LDP" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9LW5", "evidence_id": "EV-PDB-9LW5-6", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.87 }, "provenance": { "deposit_id": "9LW5", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9LW5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of dopamine bound mut-beta2-Adrenergic Receptor beta2R-M16-miniGs-Gbeta1gamma2-Nb35-scFv16 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1CNS", "C14", "LFA", "P0G" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains A,B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9Q3L", "evidence_id": "EV-PDB-9Q3L-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "9Q3L", "doi": "10.1038/s41586-026-10892-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9Q3L" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of beta2-adrenergic receptor dimer mediated by a biased allosteric modulator in lipid nanodisc" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "12P", "1PE", "A1JHU", "CLR", "EDO", "GOL", "OLC", "PLM", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RKF", "evidence_id": "EV-PDB-9RKF-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.45 }, "provenance": { "deposit_id": "9RKF", "doi": "10.1002/anie.202517995", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RKF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Dark structure of beta-2 Adrenergic receptor with photoazolol in Dark state recorded at SwissFEL" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "12P", "1PE", "A1JHU", "ACM", "CLR", "EDO", "GOL", "OLC", "PLM", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RKG", "evidence_id": "EV-PDB-9RKG-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.45 }, "provenance": { "deposit_id": "9RKG", "doi": "10.1002/anie.202517995", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RKG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Mixed model refinement of beta-2 Adrenergic receptor with photoazolol in dark state and Light state, 10 seconds after light activation, recorded at SwissFEL" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "12P", "A1JHU", "CLR", "EDO", "GOL", "OLC", "PLM", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RKH", "evidence_id": "EV-PDB-9RKH-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "9RKH", "doi": "10.1002/anie.202517995", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RKH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Dark structure of beta-2 Adrenergic receptor with photoazolol in Dark state recorded at LCLS" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "12P", "1PE", "A1JHU", "ACM", "CLR", "EDO", "GOL", "OLC", "PLM", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RKI", "evidence_id": "EV-PDB-9RKI-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "9RKI", "doi": "10.1002/anie.202517995", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RKI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Mixed model refinement of beta-2 Adrenergic receptor with photoazolol in dark state and Light state, 17 nanoseconds after light activation, recorded at LCLS" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Gonadotropin-releasing hormone receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9U4Y", "evidence_id": "EV-PDB-9U4Y-6", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.67 }, "provenance": { "deposit_id": "9U4Y", "doi": "10.1073/pnas.2500112122", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9U4Y" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "cryo-EM structure of Xenopus laevis GnRHR bound with mammal GnRH" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "B40" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9U9V", "evidence_id": "EV-PDB-9U9V-5", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "9U9V", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9U9V" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "beta2-adrenergic receptor in complex with methamphetamine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "LTX", "Y01" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Cysteinyl leukotriene receptor 2,Oplophorus-luciferin 2-monooxygenase catalytic subunit (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UAM", "evidence_id": "EV-PDB-9UAM-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9UAM", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UAM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CysLTR2-LTC4-miniGq complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "BER" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,Endolysin (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9W3F", "evidence_id": "EV-PDB-9W3F-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.04 }, "provenance": { "deposit_id": "9W3F", "doi": "10.1038/s41421-026-00892-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9W3F" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human beta2-adrenergic receptor in complex with a novel antagonist" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1EV3", "CLR", "G4C", "PLM", "SK0" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,D(1A) dopamine receptor,Engineered oplophorus-luciferin 2-monooxygenase catalytic subunit (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9WEU", "evidence_id": "EV-PDB-9WEU-5", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.65 }, "provenance": { "deposit_id": "9WEU", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9WEU" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "D1R-Gs in complexed with SKF81297/LY3154207/BMSA1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1EV3", "A1EWL", "G4C", "PLM", "SK0" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,D(1A) dopamine receptor,Engineered oplophorus-luciferin 2-monooxygenase catalytic subunit (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9WG0", "evidence_id": "EV-PDB-9WG0-5", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.59 }, "provenance": { "deposit_id": "9WG0", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9WG0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "D1R-Gs in complexed with SKF81297/LY3154207/BMSA1/UNC10062" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1EV3", "A1EWF", "G4C", "LDP", "PLM" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor,D(1A) dopamine receptor,Engineered oplophorus-luciferin 2-monooxygenase catalytic subunit (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9WG6", "evidence_id": "EV-PDB-9WG6-5", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.44 }, "provenance": { "deposit_id": "9WG6", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9WG6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "D1R-Gs in complexed with Dopamine/LY3154207/BMSA1/UNC9815" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "G1I" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-2 adrenergic receptor (chains R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8GH1", "evidence_id": "EV-PDB-8GH1-1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.1 }, "provenance": { "deposit_id": "8GH1", "doi": "10.1038/s41586-024-07153-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GH1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #20 of 20)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=36284", "evidence_id": "EV-BMRB-36284", "mappings": [], "molecule_id": "P07550", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr36284", "doi": "10.13018/BMR36284", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=36284" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure of the beta2 adrenergic receptor in the full agonist bound state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 342-413; evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/35625550", "evidence_id": "EV-DISPROT-DP03692r001", "mappings": [], "molecule_id": "P07550", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 72 }, "provenance": { "deposit_id": "DP03692r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP03692" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP03692: disorder, residues 342-413" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 342-413; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/35625550", "evidence_id": "EV-DISPROT-DP03692r002", "mappings": [], "molecule_id": "P07550", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 72 }, "provenance": { "deposit_id": "DP03692r002", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP03692" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP03692: disorder, residues 342-413" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 342-413; evidence: small-angle X-ray scattering evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/35625550", "evidence_id": "EV-DISPROT-DP03692r003", "mappings": [], "molecule_id": "P07550", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 72 }, "provenance": { "deposit_id": "DP03692r003", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP03692" }, "reader": null, "source_kind": "literature", "technique": "saxs_sans", "title": "DisProt DP03692: disorder, residues 342-413" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-413", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/P07550", "evidence_id": "EV-AFDB-AF-P07550-F1", "mappings": [], "molecule_id": "P07550", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 79.12 }, "provenance": { "deposit_id": "AF-P07550-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/P07550" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-P07550-F1" } ], "models": [ { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-2RH1-1" ], "file": "models/P07550/B2AR-inactive.cif", "format": "mmCIF", "model_id": "B2AR-inactive-cif", "molecule_id": "P07550", "provenance": { "deposit_id": "2RH1", "doi": "10.1126/science.1150577", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/2RH1.cif" }, "state_id": "B2AR-inactive" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-2RH1-1" ], "file": "models/P07550/B2AR-inactive.pdb", "format": "PDB", "model_id": "B2AR-inactive-pdb", "molecule_id": "P07550", "provenance": { "deposit_id": "2RH1", "doi": "10.1126/science.1150577", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/2RH1.pdb" }, "state_id": "B2AR-inactive" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-3SN6-4" ], "file": "models/P07550/B2AR-active.cif", "format": "mmCIF", "model_id": "B2AR-active-cif", "molecule_id": "P07550", "provenance": { "deposit_id": "3SN6", "doi": "10.1038/nature10361", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/3SN6.cif" }, "state_id": "B2AR-active" }, { "assumptions": null, "basis": "observed", "constraints_used": [ "EV-PDB-3SN6-4" ], "file": "models/P07550/B2AR-active.pdb", "format": "PDB", "model_id": "B2AR-active-pdb", "molecule_id": "P07550", "provenance": { "deposit_id": "3SN6", "doi": "10.1038/nature10361", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://files.rcsb.org/download/3SN6.pdb" }, "state_id": "B2AR-active" } ], "molecule": { "components": [], "domains": [], "gene": "ADRB2", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P07550" }, "ligands": [ "(R)-adrenaline", "(S)-carazolol", "(S)-timolol" ], "modifications": [ { "kind": "ptm", "name": "Phosphotyrosine", "position": 141, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 246, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by PKA", "position": 261, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by PKA", "position": 262, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by PKA", "position": 345, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by PKA", "position": 346, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by BARK", "position": 355, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by BARK", "position": 356, "source": "UniProtKB" }, { "kind": "ptm", "name": "4-hydroxyproline", "position": 382, "source": "UniProtKB" }, { "kind": "ptm", "name": "4-hydroxyproline", "position": 395, "source": "UniProtKB" } ], "molecule_id": "P07550", "molecule_type": "protein", "name": "Beta-2 adrenergic receptor", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P07550", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07550/entry" }, "sequence": "MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL", "sequence_length": 413 }, "molecule_id": "P07550", "states": [ { "assumptions": [], "basis": "observed", "description": "Inactive receptor bound to the inverse agonist carazolol, as in 2RH1 (T4 lysozyme fusion).", "family_label": { "terms": { "activation": "inactive" }, "vocabulary": "gpcr" }, "molecule_id": "P07550", "name": "inactive (inverse agonist-bound)", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P07550.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P07550.yaml" }, "representative_model": "B2AR-inactive-cif", "secondary_structure": null, "state_id": "B2AR-inactive", "status": "draft" }, { "assumptions": [], "basis": "observed", "description": "Agonist-bound receptor in complex with Gs, as in 3SN6.", "family_label": { "terms": { "activation": "active" }, "vocabulary": "gpcr" }, "molecule_id": "P07550", "name": "active (Gs-coupled)", "parent_state": null, "population": null, "provenance": { "deposit_id": null, "doi": null, "licence": "Project licence (pending decision)", "retrieved": "2026-10-19", "source": "Conformome curation (P07550.yaml)", "url": "https://github.com/matth55/conformome/blob/HEAD/curation/P07550.yaml" }, "representative_model": "B2AR-active-cif", "secondary_structure": null, "state_id": "B2AR-active", "status": "draft" } ], "transitions": [] }