{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "microed", "nmr_structure", "nmr_dynamics", "nmr_shifts", "saxs_sans", "cd", "force_spectroscopy", "integrative", "af_prediction", "md" ], "unmapped_evidence": 380 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 3.85 }, "construct": { "description": "Type IIIb beta-amyloid 40 Filament (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/12GB", "evidence_id": "EV-PDB-12GB-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "12GB", "doi": "10.1073/pnas.2603575123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/12GB" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "High Resolution Structure of Monomorphic AB1-40 Fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1AAP", "evidence_id": "EV-PDB-1AAP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "1AAP", "doi": "10.1021/bi00495a002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1AAP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AMYLOID BETA PEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1QCM", "evidence_id": "EV-PDB-1QCM-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1QCM", "doi": "10.1021/bi961598j", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1QCM" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "AMYLOID BETA PEPTIDE (25-35), NMR, 20 STRUCTURES" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 3.85 }, "construct": { "description": "PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1TAW", "evidence_id": "EV-PDB-1TAW-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "1TAW", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1TAW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "BOVINE TRYPSIN COMPLEXED TO APPI" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1TKN", "evidence_id": "EV-PDB-1TKN-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1TKN", "doi": "10.1021/bi049041o", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1TKN" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "13-MER PEPTIDE (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1X11", "evidence_id": "EV-PDB-1X11-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "1X11", "doi": "10.1093/emboj/16.20.6141", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1X11" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X11 PTB DOMAIN" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Alzheimer's disease amyloid (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1Z0Q", "evidence_id": "EV-PDB-1Z0Q-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1Z0Q", "doi": "10.1002/cbic.200500223", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1Z0Q" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BP4", "evidence_id": "EV-PDB-2BP4-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2BP4", "doi": "10.1074/JBC.M504454200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BP4" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACM", "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -160.15 }, "construct": { "description": "abeta 1-8 peptide (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2IPU", "evidence_id": "EV-PDB-2IPU-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "2IPU", "doi": "10.1073/pnas.0705888104", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2IPU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "PFA1 Fab fragment complexed with Abeta 1-8 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.3, "salt_mM": null, "temperature_c": -258.15 }, "construct": { "description": "Beta-amyloid protein 40 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LFM", "evidence_id": "EV-PDB-2LFM-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LFM", "doi": "10.1016/j.bbrc.2011.06.133", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LFM" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "A partially folded structure of amyloid-beta(1 40) in an aqueous environment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LMQ", "evidence_id": "EV-PDB-2LMQ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LMQ", "doi": "10.1073/pnas.0806270105", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LMQ" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Negative Stagger" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 5.85 }, "construct": { "description": "P3(40) (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LNQ", "evidence_id": "EV-PDB-2LNQ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LNQ", "doi": "10.1073/pnas.1111305109", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LNQ" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "40-residue D23N beta amyloid fibril" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LMP", "evidence_id": "EV-PDB-2LMP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LMP", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LMP" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Positive Stagger" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LMO", "evidence_id": "EV-PDB-2LMO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LMO", "doi": "10.1073/pnas.0806270105", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LMO" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Negative Stagger" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Beta-amyloid protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LMN", "evidence_id": "EV-PDB-2LMN-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LMN", "doi": "10.1073/pnas.0806270105", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LMN" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Positive Stagger" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": 44.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LLM", "evidence_id": "EV-PDB-2LLM-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LLM", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LLM" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of amyloid precursor protein's transmembrane domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "DIO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "amyloid protein beta A4 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2G47", "evidence_id": "EV-PDB-2G47-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "2G47", "doi": "10.1038/nature05143", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2G47" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein precursor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FMA", "evidence_id": "EV-PDB-2FMA-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 0.85 }, "provenance": { "deposit_id": "2FMA", "doi": "10.1107/S1744309107041139", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FMA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.05, "salt_mM": null, "temperature_c": 21.85 }, "construct": { "description": "Amyloid beta A4 protein precursor (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FKL", "evidence_id": "EV-PDB-2FKL-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "2FKL", "doi": "10.1016/j.jmb.2006.12.041", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FKL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein precursor (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FK3", "evidence_id": "EV-PDB-2FK3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "2FK3", "doi": "10.1016/j.jmb.2006.12.041", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FK3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CU1" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein precursor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FK2", "evidence_id": "EV-PDB-2FK2-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "2FK2", "doi": "10.1016/j.jmb.2006.12.041", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FK2" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein precursor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FK1", "evidence_id": "EV-PDB-2FK1-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2FK1", "doi": "10.1016/j.jmb.2006.12.041", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FK1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(II)-bound" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -168.15 }, "construct": { "description": "Amyloid beta A4 protein precursor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FJZ", "evidence_id": "EV-PDB-2FJZ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.61 }, "provenance": { "deposit_id": "2FJZ", "doi": "10.1016/j.jmb.2006.12.041", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FJZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the Alzheimer's Amyloid Precursor Protein (APP) copper binding domain (residues 133 to 189) in 'small unit cell' form, metal-free" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BEG", "evidence_id": "EV-PDB-2BEG-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2BEG", "doi": "10.1073/pnas.0506723102", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BEG" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "3D Structure of Alzheimer's Abeta(1-42) fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/23WO", "evidence_id": "EV-PDB-23WO-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "23WO", "doi": "10.15302/vita.2026.07.0055", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/23WO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the de novo designed metalloprotease DP221 E85Q mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/23WN", "evidence_id": "EV-PDB-23WN-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.98 }, "provenance": { "deposit_id": "23WN", "doi": "10.15302/vita.2026.07.0055", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/23WN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the de novo designed metalloprotease DP622 E96Q mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/23WM", "evidence_id": "EV-PDB-23WM-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.13 }, "provenance": { "deposit_id": "23WM", "doi": "10.15302/vita.2026.07.0055", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/23WM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the de novo designed metalloprotease PP507 E110Q mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/21FB", "evidence_id": "EV-PDB-21FB-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "21FB", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/21FB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of minor species of Abeta fibrils from AppNL-FPsen1P117L mice" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -150.15 }, "construct": { "description": "Kunitz Protease Inhibitory Domain of Protease Nexin II (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1ZJD", "evidence_id": "EV-PDB-1ZJD-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1ZJD", "doi": "10.1074/jbc.M504990200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1ZJD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "16-mer from Alzheimer's disease amyloid Protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1ZE9", "evidence_id": "EV-PDB-1ZE9-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1ZE9", "doi": "10.1074/jbc.M504454200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1ZE9" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Zinc-binding domain of Alzheimer's disease amyloid beta-peptide complexed with a zinc (II) cation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "16-mer from Alzheimer's disease amyloid Protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1ZE7", "evidence_id": "EV-PDB-1ZE7-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1ZE7", "doi": "10.1074/jbc.M504454200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1ZE7" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in water solution at pH 6.5" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.15, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "11-mer peptide from Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1QYT", "evidence_id": "EV-PDB-1QYT-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1QYT", "doi": "10.1021/jm040773o", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1QYT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of fragment (25-35) of beta amyloid peptide in SDS micellar solution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "11-mer peptide from Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1QXC", "evidence_id": "EV-PDB-1QXC-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1QXC", "doi": "10.1021/jm040773o", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1QXC" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR structure of the fragment 25-35 of beta amyloid peptide in 20/80 v:v hexafluoroisopropanol/water mixture" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "11-mer peptide from Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1QWP", "evidence_id": "EV-PDB-1QWP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1QWP", "doi": "10.1021/jm040773o", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1QWP" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR analysis of 25-35 fragment of beta amyloid peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1OWT", "evidence_id": "EV-PDB-1OWT-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1OWT", "doi": "10.1074/jbc.M300629200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1OWT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of the Alzheimer's disease amyloid precursor protein copper binding domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AMYLOID A4 PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1MWP", "evidence_id": "EV-PDB-1MWP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "1MWP", "doi": "10.1038/7562", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1MWP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Alzheimer's disease amyloid (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1IYT", "evidence_id": "EV-PDB-1IYT-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1IYT", "doi": "10.1046/j.1432-1033.2002.03271.x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1IYT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": 9.85 }, "construct": { "description": "A-BETA AMYLOID (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1HZ3", "evidence_id": "EV-PDB-1HZ3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1HZ3", "doi": "10.1006/jsbi.2000.4288", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1HZ3" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR (chains D,I)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1CA0", "evidence_id": "EV-PDB-1CA0-4", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "1CA0", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1CA0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "BOVINE CHYMOTRYPSIN COMPLEXED TO APPI" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI) (chains I)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1BRC", "evidence_id": "EV-PDB-1BRC-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "1BRC", "doi": "10.1006/jmbi.1993.1211", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1BRC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.8, "salt_mM": null, "temperature_c": 22.85 }, "construct": { "description": "AMYLOID BETA-PEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1BJC", "evidence_id": "EV-PDB-1BJC-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1BJC", "doi": "10.1006/jsbi.2000.4267", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1BJC" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION NMR STRUCTURE OF AMYLOID BETA[F16], RESIDUES 1-28, 15 STRUCTURES" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": 22.85 }, "construct": { "description": "AMYLOID BETA-PEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1BJB", "evidence_id": "EV-PDB-1BJB-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1BJB", "doi": "10.1006/jsbi.2000.4267", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1BJB" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION NMR STRUCTURE OF AMYLOID BETA[E16], RESIDUES 1-28, 14 STRUCTURES" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.3, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "AMYLOID BETA-PEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1BA6", "evidence_id": "EV-PDB-1BA6-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1BA6", "doi": "10.1021/bi9810757", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1BA6" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION STRUCTURE OF THE METHIONINE-OXIDIZED AMYLOID BETA-PEPTIDE (1-40). DOES OXIDATION AFFECT CONFORMATIONAL SWITCHING? NMR, 10 STRUCTURES" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.1, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "AMYLOID BETA-PEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1BA4", "evidence_id": "EV-PDB-1BA4-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1BA4", "doi": "10.1021/bi972979f", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1BA4" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AMYLOID A4 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1AML", "evidence_id": "EV-PDB-1AML-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1AML", "doi": "10.1111/j.1432-1033.1995.293_1.x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1AML" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "THE ALZHEIMER`S DISEASE AMYLOID A4 PEPTIDE (RESIDUES 1-40)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AMYLOID BETA-PEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1AMC", "evidence_id": "EV-PDB-1AMC-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1AMC", "doi": "10.1021/bi00191a006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1AMC" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AMYLOID BETA-PEPTIDE (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1AMB", "evidence_id": "EV-PDB-1AMB-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1AMB", "doi": "10.1021/bi00191a006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1AMB" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "RT-Ab40(C1) (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/11EP", "evidence_id": "EV-PDB-11EP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.75 }, "provenance": { "deposit_id": "11EP", "doi": "10.64898/2026.04.10.717728", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/11EP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Rapidly twisting Amyloid-beta 40 fibril , RT-Ab40(C1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "RT-Ab40(C2) (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/11EO", "evidence_id": "EV-PDB-11EO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.73 }, "provenance": { "deposit_id": "11EO", "doi": "10.64898/2026.04.10.717728", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/11EO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Rapidly twisting Amyloid-beta 40 fibril , RT-Ab40(C2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "RT-Ab40(2_1) (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/11EN", "evidence_id": "EV-PDB-11EN-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "11EN", "doi": "10.64898/2026.04.10.717728", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/11EN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Rapidly twisting Amyloid-beta 40 fibril , RT-Ab40(2_1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta peptide fragment (chains Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2R0W", "evidence_id": "EV-PDB-2R0W-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.503 }, "provenance": { "deposit_id": "2R0W", "doi": "10.1073/pnas.0705888104", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2R0W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "PFA2 FAB complexed with Abeta1-8" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "BETA-AMYLOID PROTEIN 42 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2WK3", "evidence_id": "EV-PDB-2WK3-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.59 }, "provenance": { "deposit_id": "2WK3", "doi": "10.1016/J.JMB.2009.10.072", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2WK3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Heptapeptide from Amyloid beta A4 protein (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3GCI", "evidence_id": "EV-PDB-3GCI-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.04 }, "provenance": { "deposit_id": "3GCI", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3GCI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "BU4", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3KTM", "evidence_id": "EV-PDB-3KTM-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "3KTM", "doi": "10.1073/pnas.0911326107", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3KTM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "FMT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid beta A4 protein (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3L33", "evidence_id": "EV-PDB-3L33-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.48 }, "provenance": { "deposit_id": "3L33", "doi": "10.1074/jbc.M110.171348", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3L33" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3L81", "evidence_id": "EV-PDB-3L81-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "3L81", "doi": "10.1016/j.devcel.2010.01.015", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3L81" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "OS" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3NYJ", "evidence_id": "EV-PDB-3NYJ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "3NYJ", "doi": "10.1021/bi101846x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3NYJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure Analysis of APP E2 domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3NYL", "evidence_id": "EV-PDB-3NYL-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "3NYL", "doi": "10.1016/j.molcel.2004.06.037", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3NYL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SV1", "evidence_id": "EV-PDB-3SV1-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "3SV1", "doi": "10.1093/jmcb/mjs033", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SV1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of APP peptide bound rat Mint2 PARM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3U0T", "evidence_id": "EV-PDB-3U0T-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "3U0T", "doi": "10.1016/j.jmb.2011.11.047", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3U0T" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fab-antibody complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3Q2X", "evidence_id": "EV-PDB-3Q2X-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.451 }, "provenance": { "deposit_id": "3Q2X", "doi": "10.1073/pnas.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3Q2X" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PZZ", "evidence_id": "EV-PDB-3PZZ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.29 }, "provenance": { "deposit_id": "3PZZ", "doi": "10.1073/pnas.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PZZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "KLVFFA hexapeptide segment from Amyloid beta (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3OW9", "evidence_id": "EV-PDB-3OW9-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3OW9", "doi": "10.1073/pnas.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3OW9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of an amyloid forming peptide KLVFFA from amyloid beta, alternate polymorph II" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ORA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "KLVFFA hexapeptide segment from Amyloid beta (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3OVJ", "evidence_id": "EV-PDB-3OVJ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3OVJ", "doi": "10.1371/journal.pbio.1001080", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3OVJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AICD peptide E683V variant (chains L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3MXY", "evidence_id": "EV-PDB-3MXY-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "3MXY", "doi": "10.1016/j.jmb.2011.09.046", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3MXY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AICD peptide (chains L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3MXC", "evidence_id": "EV-PDB-3MXC-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "3MXC", "doi": "10.1016/j.jmb.2011.09.046", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3MXC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "New antigen receptor variable domain,P3(40) peptide from Amyloid beta A4 protein,New antigen receptor variable domain (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3MOQ", "evidence_id": "EV-PDB-3MOQ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.054 }, "provenance": { "deposit_id": "3MOQ", "doi": "10.1523/JNEUROSCI.4259-10.2011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3MOQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "octapeptide from Amyloid beta A4 protein (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3JTI", "evidence_id": "EV-PDB-3JTI-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3JTI", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3JTI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the complex formed between Phospholipase A2 with beta-amyloid fragment, Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met at 1.8 A resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Amyloid Beta Peptide (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3JQL", "evidence_id": "EV-PDB-3JQL-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.2 }, "provenance": { "deposit_id": "3JQL", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3JQL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Amyloid Beta Peptide (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3JQ5", "evidence_id": "EV-PDB-3JQ5-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.03 }, "provenance": { "deposit_id": "3JQ5", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3JQ5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains P,Q,R,S)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IFP", "evidence_id": "EV-PDB-3IFP-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "3IFP", "doi": "10.1074/jbc.M109.045187", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IFP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IFO", "evidence_id": "EV-PDB-3IFO-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.15 }, "provenance": { "deposit_id": "3IFO", "doi": "10.1074/jbc.M109.045187", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IFO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IFN", "evidence_id": "EV-PDB-3IFN-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "3IFN", "doi": "10.1074/jbc.M109.045187", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IFN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IFL", "evidence_id": "EV-PDB-3IFL-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "3IFL", "doi": "10.1074/jbc.M109.045187", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IFL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3DXE", "evidence_id": "EV-PDB-3DXE-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "3DXE", "doi": "10.1038/embor.2008.188", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3DXE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3DXD", "evidence_id": "EV-PDB-3DXD-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "3DXD", "doi": "10.1038/embor.2008.188", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3DXD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3DXC", "evidence_id": "EV-PDB-3DXC-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "3DXC", "doi": "10.1038/embor.2008.188", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3DXC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid Beta Peptide (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3BKJ", "evidence_id": "EV-PDB-3BKJ-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.59 }, "provenance": { "deposit_id": "3BKJ", "doi": "10.1016/j.jmb.2007.12.036", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3BKJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid Beta Peptide (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3BAE", "evidence_id": "EV-PDB-3BAE-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.593 }, "provenance": { "deposit_id": "3BAE", "doi": "10.1016/j.jmb.2007.12.036", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3BAE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Fab WO2 bound to the N terminal domain of Amyloid beta peptide (1-28)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid beta A4 protein (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3AYU", "evidence_id": "EV-PDB-3AYU-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "3AYU", "doi": "10.1074/jbc.M111.264176", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3AYU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid-beta protein 40,HLA class II histocompatibility antigen, DRB1 beta chain (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/31VO", "evidence_id": "EV-PDB-31VO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "31VO", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/31VO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of amyloid beta 1-15 fragment bound to HLA-DR1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains A,B,C,G)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2Y3L", "evidence_id": "EV-PDB-2Y3L-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "2Y3L", "doi": "10.1073/PNAS.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2Y3L" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2Y3K", "evidence_id": "EV-PDB-2Y3K-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2Y3K", "doi": "10.1073/PNAS.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2Y3K" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2Y3J", "evidence_id": "EV-PDB-2Y3J-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.99 }, "provenance": { "deposit_id": "2Y3J", "doi": "10.1073/PNAS.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2Y3J" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2Y2A", "evidence_id": "EV-PDB-2Y2A-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.91 }, "provenance": { "deposit_id": "2Y2A", "doi": "10.1073/PNAS.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2Y2A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2Y29", "evidence_id": "EV-PDB-2Y29-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "2Y29", "doi": "10.1073/PNAS.1112600108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2Y29" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Amyloid beta A4 protein (chains C)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2OTK", "evidence_id": "EV-PDB-2OTK-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2OTK", "doi": "10.1073/pnas.0711731105", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2OTK" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of Alzheimer Ab peptide in complex with an engineered binding protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 3.85 }, "construct": { "description": "Beta-amyloid protein 42 (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2NAO", "evidence_id": "EV-PDB-2NAO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2NAO", "doi": "10.1073/pnas.1600749113", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2NAO" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Atomic resolution structure of a disease-relevant Abeta(1-42) amyloid fibril" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 9.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MXU", "evidence_id": "EV-PDB-2MXU-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MXU", "doi": "10.1038/nsmb.2991", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MXU" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "42-Residue Beta Amyloid Fibril" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 9.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MVX", "evidence_id": "EV-PDB-2MVX-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MVX", "doi": "10.1002/anie.201408598", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MVX" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Atomic-resolution 3D structure of amyloid-beta fibrils: the Osaka mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MPZ", "evidence_id": "EV-PDB-2MPZ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MPZ", "doi": "10.1016/j.str.2014.10.022", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MPZ" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Atomic model of the Abeta D23N \"Iowa\" mutant using solid-state NMR, EM and Rosetta modeling" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MJ1", "evidence_id": "EV-PDB-2MJ1-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MJ1", "doi": "10.1042/BSR20140094", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MJ1" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR structure of the soluble A beta 17-34 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 0.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MGT", "evidence_id": "EV-PDB-2MGT-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MGT", "doi": "10.1038/srep21734", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MGT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Zinc induced dimer of the metal binding domain 1-16 of human amyloid beta-peptide with Alzheimer's disease pathogenic English mutation H6R" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "23Y" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2M9S", "evidence_id": "EV-PDB-2M9S-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2M9S", "doi": "10.1016/j.bbagen.2013.06.031", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2M9S" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "23Y" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2M9R", "evidence_id": "EV-PDB-2M9R-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2M9R", "doi": "10.1016/j.bbagen.2013.06.031", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2M9R" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 14.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2M4J", "evidence_id": "EV-PDB-2M4J-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2M4J", "doi": "10.1016/j.cell.2013.08.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2M4J" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "40-residue beta-amyloid fibril derived from Alzheimer's disease brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 39.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LZ4", "evidence_id": "EV-PDB-2LZ4-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LZ4", "doi": "10.1038/ncomms4037", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LZ4" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR structure of transmembrane domain of amyloid precursor protein V44M" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 39.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LZ3", "evidence_id": "EV-PDB-2LZ3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LZ3", "doi": "10.1038/ncomms4037", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LZ3" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR structure of transmembrane domain of amyloid precursor protein WT" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 44.85 }, "construct": { "description": "C99 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LP1", "evidence_id": "EV-PDB-2LP1-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LP1", "doi": "10.1126/science.1219988", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LP1" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": 44.85 }, "construct": { "description": "P3(42) (chains A,B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LOH", "evidence_id": "EV-PDB-2LOH-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LOH", "doi": "10.1016/j.febslet.2012.04.062", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LOH" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "CD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3UMH", "evidence_id": "EV-PDB-3UMH-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "3UMH", "doi": "10.1016/j.jmb.2011.12.057", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3UMH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "CD", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3UMI", "evidence_id": "EV-PDB-3UMI-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "3UMI", "doi": "10.1016/j.jmb.2011.12.057", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3UMI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "CD", "CU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3UMK", "evidence_id": "EV-PDB-3UMK-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "3UMK", "doi": "10.1016/j.jmb.2011.12.057", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3UMK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Beta-amyloid protein 40 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4HIX", "evidence_id": "EV-PDB-4HIX-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.204 }, "provenance": { "deposit_id": "4HIX", "doi": "10.1038/srep01302", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4HIX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CU", "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4JFN", "evidence_id": "EV-PDB-4JFN-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "4JFN", "doi": "10.1523/JNEUROSCI.0180-14.2014", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4JFN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid beta A4 protein (chains G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4M1C", "evidence_id": "EV-PDB-4M1C-4", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5007 }, "provenance": { "deposit_id": "4M1C", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4M1C" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4MDR", "evidence_id": "EV-PDB-4MDR-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "4MDR", "doi": "10.1371/journal.pone.0088147", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4MDR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.25, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Beta-amyloid protein 40 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4MVI", "evidence_id": "EV-PDB-4MVI-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "4MVI", "doi": "10.1042/BCJ20160114", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4MVI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid peptide fragment VFFAED (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4MVK", "evidence_id": "EV-PDB-4MVK-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "4MVK", "doi": "10.1042/BCJ20160114", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4MVK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Beta-amyloid protein 40 (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4MVL", "evidence_id": "EV-PDB-4MVL-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "4MVL", "doi": "10.1042/BCJ20160114", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4MVL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -159.65 }, "construct": { "description": "Beta-amyloid protein 40 (chains B,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4NGE", "evidence_id": "EV-PDB-4NGE-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.704 }, "provenance": { "deposit_id": "4NGE", "doi": "10.1016/j.str.2014.05.003", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4NGE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4OJF", "evidence_id": "EV-PDB-4OJF-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.998 }, "provenance": { "deposit_id": "4OJF", "doi": "10.1107/S2053230X14001642", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4OJF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Humanised 3D6 Fab complexed to amyloid beta 1-8" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4ONF", "evidence_id": "EV-PDB-4ONF-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "4ONF", "doi": "10.1186/alzrt261", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4ONF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fab fragment of 3D6 in complex with amyloid beta 1-7" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "IMD", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4ONG", "evidence_id": "EV-PDB-4ONG-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "4ONG", "doi": "10.1186/alzrt261", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4ONG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fab fragment of 3D6 in complex with amyloid beta 1-40" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4PQD", "evidence_id": "EV-PDB-4PQD-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.332 }, "provenance": { "deposit_id": "4PQD", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4PQD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The longer crystal structure of the grow factor like domain from Beta amypoid precusor protein (APP22-126)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4PWQ", "evidence_id": "EV-PDB-4PWQ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "4PWQ", "doi": "10.1016/j.jmb.2014.12.005", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4PWQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN of THE AMYLOID PRECURSOR PROTEIN" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid-beta fragment (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4XXD", "evidence_id": "EV-PDB-4XXD-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.41 }, "provenance": { "deposit_id": "4XXD", "doi": "10.1038/srep09649", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4XXD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of mid-region amyloid beta capture by solanezumab" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains A,B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AEF", "evidence_id": "EV-PDB-5AEF-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 5.0 }, "provenance": { "deposit_id": "5AEF", "doi": "10.1073/PNAS.1503455112", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AEF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Electron cryo-microscopy of an Abeta(1-42)amyloid fibril" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NAG", "P6G", "PEG", "SO4", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "BETA-AMYLOID PROTEIN 42 (chains P,Q,R,S)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AM8", "evidence_id": "EV-PDB-5AM8-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "5AM8", "doi": "10.1111/FEBS.13647", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AM8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 4-10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "P6G", "PEG", "PG4", "ZN", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "AMYLOID BETA A4 PROTEIN (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AMB", "evidence_id": "EV-PDB-5AMB-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.55 }, "provenance": { "deposit_id": "5AMB", "doi": "10.1111/FEBS.13647", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AMB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 35-42" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "CA", "GOL", "MG", "SCN", "SO4", "ZN", "branched: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5BUO", "evidence_id": "EV-PDB-5BUO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.31 }, "provenance": { "deposit_id": "5BUO", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5BUO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "A receptor molecule" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains C,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5C67", "evidence_id": "EV-PDB-5C67-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.83 }, "provenance": { "deposit_id": "5C67", "doi": "10.1042/BJ20151410", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5C67" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human Mesotrypsin in complex with amyloid precursor protein inhibitor variant APPI-M17G/I18F/F34V" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains D,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5CSZ", "evidence_id": "EV-PDB-5CSZ-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "5CSZ", "doi": "10.3233/JAD-2011-110977", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5CSZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.4, "salt_mM": null, "temperature_c": -140.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5HOW", "evidence_id": "EV-PDB-5HOW-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.295 }, "provenance": { "deposit_id": "5HOW", "doi": "10.1021/jacs.6b01332", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5HOW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "JEF" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5HOX", "evidence_id": "EV-PDB-5HOX-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "5HOX", "doi": "10.1021/jacs.6b01332", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5HOX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV)." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "JEF" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": -140.15 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5HOY", "evidence_id": "EV-PDB-5HOY-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.295 }, "provenance": { "deposit_id": "5HOY", "doi": "10.1021/jacs.6b01332", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5HOY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV)." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": 3.85 }, "construct": { "description": "Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5KK3", "evidence_id": "EV-PDB-5KK3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5KK3", "doi": "10.1021/jacs.6b05129", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5KK3" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 4.85 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5LFY", "evidence_id": "EV-PDB-5LFY-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5LFY", "doi": "10.1002/anie.201704615", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5LFY" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Zinc bound dimer of the fragment of human amyloid-beta peptide with Alzheimer's disease pathogenic Taiwanese mutation D7H" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "GLY-VAL-VAL amyloid 35-40 fragment (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5LV0", "evidence_id": "EV-PDB-5LV0-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "5LV0", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5LV0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Pyroglutamate-Abeta pE3-12-PEGb (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MY4", "evidence_id": "EV-PDB-5MY4-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.211 }, "provenance": { "deposit_id": "5MY4", "doi": "10.1074/jbc.M117.777839", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MY4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein (chains E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MYO", "evidence_id": "EV-PDB-5MYO-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.59 }, "provenance": { "deposit_id": "5MYO", "doi": "10.1074/jbc.M117.777839", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MYO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Pyroglutamate-Abeta pE3-18 (chains E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MYX", "evidence_id": "EV-PDB-5MYX-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.492 }, "provenance": { "deposit_id": "5MYX", "doi": "10.1074/jbc.M117.777839", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MYX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid-beta A4 protein (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5NX1", "evidence_id": "EV-PDB-5NX1-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.853 }, "provenance": { "deposit_id": "5NX1", "doi": "10.1074/jbc.RA117.000871", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5NX1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid-beta A4 protein (chains D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5NX1", "evidence_id": "EV-PDB-5NX1-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.853 }, "provenance": { "deposit_id": "5NX1", "doi": "10.1074/jbc.RA117.000871", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5NX1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; 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"data_level": "processed", "data_link": "https://www.rcsb.org/structure/6OIZ", "evidence_id": "EV-PDB-6OIZ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.1 }, "provenance": { "deposit_id": "6OIZ", "doi": "10.1038/s41467-019-11183-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6OIZ" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "Amyloid-Beta (20-34) wild type" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": 37.0 }, "construct": { "description": "Amyloid beta A4 protein (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RHY", "evidence_id": "EV-PDB-6RHY-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6RHY", "doi": "10.1038/s41467-020-16566-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RHY" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of pore-forming amyloid-beta tetramers" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6XOV", "evidence_id": "EV-PDB-6XOV-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "6XOV", "doi": "10.1038/s41467-022-29322-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6XOV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "CryoEM structure of human presequence protease in partial closed state 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Amyloid-beta precursor protein I45T mutant (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YHX", "evidence_id": "EV-PDB-6YHX-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6YHX", "doi": "10.1021/acschemneuro.0c00640", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YHX" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR Structure of APP I45T mutant TMD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Isoform L-APP677 of Amyloid-beta precursor protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B3J", "evidence_id": "EV-PDB-7B3J-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "7B3J", "doi": "10.1021/acs.jmedchem.1c00632", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B3J" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -150.0 }, "construct": { "description": "Amyloid-beta 17-36 peptide (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7JXO", "evidence_id": "EV-PDB-7JXO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.81 }, "provenance": { "deposit_id": "7JXO", "doi": "10.1021/jacs.0c09281", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7JXO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Triangular trimer of beta-hairpins derived from Abeta17-36 with an F20Cha mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 7.85 }, "construct": { "description": "Amyloid-beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8B9R", "evidence_id": "EV-PDB-8B9R-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "8B9R", "doi": "10.1021/jacsau.2c00438", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8B9R" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8BFZ", "evidence_id": "EV-PDB-8BFZ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "8BFZ", "doi": "10.1007/s00401-022-02533-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8BFZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "GLN-LYS-CYS-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-CYS-GLY (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8H8Q", "evidence_id": "EV-PDB-8H8Q-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "8H8Q", "doi": "10.1016/j.bbrc.2025.151655", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8H8Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fab-amyloid beta fragment complex at neutral pH" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "P3(40) (chains A,B,C,D,F,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8KEW", "evidence_id": "EV-PDB-8KEW-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 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"unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8KF4", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8KF4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8KF3", "evidence_id": "EV-PDB-8KF3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8KF3", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8KF3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The cryo-EM structure of type3 amyloid beta 42 fibril." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "VW6" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "P3(40) (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8KF1", "evidence_id": "EV-PDB-8KF1-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8KF1", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8KF1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -163.15 }, "construct": { "description": "Beta-amyloid (chains B,D,F,H,J,L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I4O", "evidence_id": "EV-PDB-8I4O-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8I4O", "doi": "10.1021/jacsau.3c00445", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I4O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Design of a split green fluorescent protein for sensing and tracking an beta-amyloid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,a,b,c)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8FF3", "evidence_id": "EV-PDB-8FF3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.09 }, "provenance": { "deposit_id": "8FF3", "doi": "10.1016/j.jsb.2024.108092", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8FF3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid-beta (1-40) fibrils derived from familial Dutch-type CAA patient (population B)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,I,J,K)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8FF2", "evidence_id": "EV-PDB-8FF2-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.87 }, "provenance": { "deposit_id": "8FF2", "doi": "10.1016/j.jsb.2024.108092", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8FF2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid-beta (1-40) fibrils derived from a CAA patient" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8EZE", "evidence_id": "EV-PDB-8EZE-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.76 }, "provenance": { "deposit_id": "8EZE", "doi": "10.1073/pnas.2218831120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8EZE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Brain-derived 42-residue amyloid-beta fibril type B" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8EZD", "evidence_id": "EV-PDB-8EZD-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "8EZD", "doi": "10.1073/pnas.2218831120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8EZD" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Brain-derived 42-residue amyloid-beta fibril type A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "P3(40) (chains D,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8C3H", "evidence_id": "EV-PDB-8C3H-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.71 }, "provenance": { "deposit_id": "8C3H", "doi": "10.1016/j.bbrc.2023.01.051", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8C3H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex a long aspartimide degron peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8BG0", "evidence_id": "EV-PDB-8BG0-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.99 }, "provenance": { "deposit_id": "8BG0", "doi": "10.1007/s00401-022-02533-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8BG0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8BFB", "evidence_id": "EV-PDB-8BFB-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8BFB", "doi": "10.1038/s41467-023-38495-5", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8BFB" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Sarkosyl-extracted AppNL-G-F Abeta42 fibril 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"deposit", "technique": "cryoem", "title": "Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CU" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 7.85 }, "construct": { "description": "Amyloid-beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8B9Q", "evidence_id": "EV-PDB-8B9Q-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "8B9Q", "doi": "10.1021/jacsau.2c00438", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8B9Q" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8AZT", "evidence_id": "EV-PDB-8AZT-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "8AZT", "doi": 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"https://www.rcsb.org/structure/7Y8Q", "evidence_id": "EV-PDB-7Y8Q-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "7Y8Q", "doi": "10.1021/acschemneuro.3c00192", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Y8Q" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Amyloid-beta assemblage on GM1-containing membranes" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "ALA-LEU-VAL-PHE-PHE-ALA-PRO-ASP-VAL-GLY-SER (chains A)", "labels": [] }, 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"labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WVY", "evidence_id": "EV-PDB-7WVY-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "7WVY", "doi": "10.1038/s41467-022-29361-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WVY" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta A4 protein-binding family B member 1 (protein) (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WFY", "evidence_id": "EV-PDB-7WFY-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.449 }, "provenance": { "deposit_id": "7WFY", "doi": "10.1038/s41598-022-16883-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WFY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -160.15 }, "construct": { "description": "Amyloid-beta 17-36 peptide (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7U4P", "evidence_id": "EV-PDB-7U4P-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.803 }, "provenance": { "deposit_id": "7U4P", "doi": "10.1021/acscentsci.3c00592", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7U4P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL" ], "notes": 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"buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "UNX" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Q4M", "evidence_id": "EV-PDB-7Q4M-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "7Q4M", "doi": "10.1126/science.abm7285", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Q4M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Type II beta-amyloid 42 Filaments from 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"cryoem", "title": "Type I beta-amyloid 42 Filaments from Human Brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid-beta precursor protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7OXN", "evidence_id": "EV-PDB-7OXN-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "7OXN", "doi": "10.1038/s41380-021-01385-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7OXN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FLC" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid-beta precursor protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7OW1", "evidence_id": "EV-PDB-7OW1-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "7OW1", "doi": "10.1038/s41380-021-01385-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7OW1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of TAP01 in complex with amyloid beta peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Alpha-hemolysin hybridized Abeta (chains A,B,C,D,E,F,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7O1Q", "evidence_id": "EV-PDB-7O1Q-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7O1Q", "doi": "10.1002/anie.202104497", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7O1Q" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid beta oligomer displayed on the alpha hemolysin scaffold" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -150.0 }, "construct": { "description": "Amyloid-beta 17-36 peptide (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7JXN", "evidence_id": "EV-PDB-7JXN-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "7JXN", "doi": "10.1021/jacs.0c09281", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7JXN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Beta hairpin derived from Abeta17-36 with an F20Cha mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACY", "branched: beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7F29", "evidence_id": "EV-PDB-7F29-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "7F29", "doi": "10.1021/jacs.1c08607", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7F29" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "PEG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Amyloid beta fragment with an intramolecular disulfide bond at positions 17 and 28 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7E6P", "evidence_id": "EV-PDB-7E6P-3", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "7E6P", "doi": "10.1021/acschemneuro.1c00416", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7E6P" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fab-amyloid beta fragment complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Isoform L-APP677 of Amyloid-beta precursor protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B3K", "evidence_id": "EV-PDB-7B3K-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "7B3K", "doi": "10.1021/acs.jmedchem.1c00632", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B3K" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Amyloid-beta precursor protein V44M mutant (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YHP", "evidence_id": "EV-PDB-6YHP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6YHP", "doi": "10.1021/acschemneuro.0c00640", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YHP" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR Structure of APP V44M mutant TMD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Amyloid-beta precursor protein G38P mutant (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YHO", "evidence_id": "EV-PDB-6YHO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6YHO", "doi": "10.1021/acschemneuro.0c00640", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YHO" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR Structure of APP G38P mutant TM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Amyloid-beta precursor protein G38L mutant (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YHI", "evidence_id": "EV-PDB-6YHI-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6YHI", "doi": "10.1021/acschemneuro.0c00640", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YHI" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR Structure of APP G38L mutant TMD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Amyloid-beta precursor protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YHF", "evidence_id": "EV-PDB-6YHF-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6YHF", "doi": "10.1021/acschemneuro.0c00640", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YHF" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution NMR Structure of APP TMD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "HEZ" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": -160.0 }, "construct": { "description": "Amyloid-beta protein (chains A,B,C,D,E,F,G,H,I,J,K)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6WXM", "evidence_id": "EV-PDB-6WXM-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "6WXM", "doi": "10.1021/acschemneuro.0c00290", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6WXM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 16-36" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 23.85 }, "construct": { "description": "Amyloid-beta precursor protein (chains 1,2,3,4,5,6)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6W0O", "evidence_id": "EV-PDB-6W0O-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.77 }, "provenance": { "deposit_id": "6W0O", "doi": "10.1073/pnas.2023089118", "licence": "CC0 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"provenance": { "deposit_id": "6TI7", "doi": "10.1039/d0cc02463e", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6TI7" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": 9.85 }, "construct": { "description": "Amyloid-beta precursor protein (chains A,C,E,G,J,L,N,P)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6TI7", "evidence_id": "EV-PDB-6TI7-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6TI7", "doi": "10.1039/d0cc02463e", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6TI7" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": 9.85 }, "construct": { "description": "Amyloid-beta precursor protein (chains B,D,F,H,J,L,N,P)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6TI6", "evidence_id": "EV-PDB-6TI6-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6TI6", "doi": "10.1039/d0cc02463e", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6TI6" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": 9.85 }, "construct": { "description": "Amyloid-beta precursor protein (chains A,C,E,G,I,K,M,O)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6TI6", "evidence_id": "EV-PDB-6TI6-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6TI6", "doi": "10.1039/d0cc02463e", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6TI6" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": 9.85 }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6TI5", "evidence_id": "EV-PDB-6TI5-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6TI5", "doi": "10.1039/d0cc02463e", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6TI5" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "A New Structural Model of Abeta(1-40) Fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.4, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Amyloid-beta precursor protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SZF", "evidence_id": "EV-PDB-6SZF-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6SZF", "doi": "10.3390/ph14080732", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SZF" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the amyloid beta-peptide (1-42)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SHS", "evidence_id": "EV-PDB-6SHS-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.4 }, "provenance": { "deposit_id": "6SHS", "doi": "10.1038/s41467-019-12683-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SHS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Abeta fibril (Morphology I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OL3", "evidence_id": "EV-PDB-8OL3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8OL3", "doi": "10.1038/s41593-023-01484-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OL3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Murine type III Abeta fibril from APP/PS1 mouse" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OT1", "evidence_id": "EV-PDB-8OT1-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.59 }, "provenance": { "deposit_id": "8OT1", "doi": "10.1016/j.jmb.2023.168422", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OT1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "unseeded Abeta(1-40) amyloid fibril (morphology i)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OT3", "evidence_id": "EV-PDB-8OT3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.73 }, "provenance": { "deposit_id": "8OT3", "doi": "10.1016/j.jmb.2023.168422", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OT3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "unseeded Abeta(1-40) amyloid fibril (morphology ii)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OT4", "evidence_id": "EV-PDB-8OT4-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.97 }, "provenance": { "deposit_id": "8OT4", "doi": "10.1016/j.jmb.2023.168422", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OT4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "seeded Abeta(1-40) amyloid fibril (morphology I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OTF", "evidence_id": "EV-PDB-8OTF-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8OTF", "doi": "10.1073/pnas.2306767120", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OTF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Ab typeII filament from Guam ALS/PDC" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OVK", "evidence_id": "EV-PDB-8OVK-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.88 }, "provenance": { "deposit_id": "8OVK", "doi": "10.1038/s41467-023-43822-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OVK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Lipidic amyloid-beta(1-40) fibril - polymorph L1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OVM", "evidence_id": "EV-PDB-8OVM-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.24 }, "provenance": { "deposit_id": "8OVM", "doi": "10.1038/s41467-023-43822-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OVM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Lipidic amyloid-beta(1-40) fibril - polymorph L2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OWD", "evidence_id": "EV-PDB-8OWD-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.28 }, "provenance": { "deposit_id": "8OWD", "doi": "10.1038/s41467-023-43822-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OWD" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Lipidic amyloid-beta(1-40) fibril - polymorph L3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OWE", "evidence_id": "EV-PDB-8OWE-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.75 }, "provenance": { "deposit_id": "8OWE", "doi": "10.1038/s41467-023-43822-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OWE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Lipidic amyloid-beta(1-40) fibril - polymorph L2-L3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OWJ", "evidence_id": "EV-PDB-8OWJ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.75 }, "provenance": { "deposit_id": "8OWJ", "doi": "10.1038/s41467-023-43822-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OWJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OWK", "evidence_id": "EV-PDB-8OWK-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.86 }, "provenance": { "deposit_id": "8OWK", "doi": "10.1038/s41467-023-43822-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OWK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Lipidic amyloid-beta(1-40) fibril - polymorph L3-L3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QN6", "evidence_id": "EV-PDB-8QN6-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "8QN6", "doi": "10.1186/s40478-023-01694-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QN6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta A4 protein (chains A)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QN7", "evidence_id": "EV-PDB-8QN7-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7 }, "provenance": { "deposit_id": "8QN7", "doi": "10.1186/s40478-023-01694-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QN7" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Type IIIb beta-amyloid 40 Filament (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SEK", "evidence_id": "EV-PDB-8SEK-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "8SEK", "doi": "10.1038/s41594-024-01252-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SEK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Type IIIa beta-amyloid 40 Filaments from Down syndrome" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "YWK" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "amyloid beta segment 35-MVGGVV-40, racemic mixture (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8T82", "evidence_id": "EV-PDB-8T82-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.1 }, "provenance": { "deposit_id": "8T82", "doi": "10.1021/jacs.3c11712", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8T82" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes pentafluoropropionic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "TFA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Racemic mixture of amyloid beta segment 16-KLVFFA-21 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8T89", "evidence_id": "EV-PDB-8T89-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "8T89", "doi": "10.1021/jacs.3c11712", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8T89" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Racemic mixture of amyloid beta segment 16-KLVFFA-21 forms heterochiral rippled beta-sheet" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "NAG", "PC1", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8X52", "evidence_id": "EV-PDB-8X52-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8X52", "doi": "10.1126/science.adn5820", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8X52" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human gamma-secretase in complex with Abeta49" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "NAG", "PC1", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8X54", "evidence_id": "EV-PDB-8X54-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "8X54", "doi": "10.1126/science.adn5820", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8X54" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human gamma-secretase in complex with APP-C99" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains e)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8Z9V", "evidence_id": "EV-PDB-8Z9V-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 7.84 }, "provenance": { "deposit_id": "8Z9V", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8Z9V" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid beta and TTR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A8F", "evidence_id": "EV-PDB-9A8F-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A8F", "doi": "10.1126/sciadv.adr7008", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A8F" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Type II Amyloid beta Fibril MEMMI ensemble" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CK6", "evidence_id": "EV-PDB-9CK6-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "9CK6", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CK6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of sarkosyl insoluble amyloid-beta 42 filaments extracted from human brain tissue" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CKI", "evidence_id": "EV-PDB-9CKI-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9CKI", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CKI" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the poly(4-styrenesulfonic acid-co-maleic acid) [PSCMA]-extractable amyloid-beta 42 oligomer from human brain tissue (Conformation 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CZN", "evidence_id": "EV-PDB-9CZN-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "9CZN", "doi": "10.1007/s00401-024-02786-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CZN" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Type Ic amyloid-beta 42 filaments in dominantly inherited Alzheimer disease with cotton wool plaques" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CZP", "evidence_id": "EV-PDB-9CZP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9CZP", "doi": "10.1007/s00401-024-02786-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CZP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Type Id amyloid-beta 42 filaments in dominantly inherited Alzheimer disease with cotton wool plaques" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FH3", "evidence_id": "EV-PDB-9FH3-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.9 }, "provenance": { "deposit_id": "9FH3", "doi": "10.1186/s40478-025-02120-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FH3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FH4", "evidence_id": "EV-PDB-9FH4-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.0 }, "provenance": { "deposit_id": "9FH4", "doi": "10.1186/s40478-025-02120-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FH4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FH5", "evidence_id": "EV-PDB-9FH5-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "9FH5", "doi": "10.1186/s40478-025-02120-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FH5" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains 2,3,4,5,6,A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f,g,h,i)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9IIO", "evidence_id": "EV-PDB-9IIO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9IIO", "doi": "10.3390/ijms26031179", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9IIO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "J-shaped conformer of amyloid beta (1-40)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,AA,B,BB,C,CC,D,DD,E,EE,F,FF)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9JAZ", "evidence_id": "EV-PDB-9JAZ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "9JAZ", "doi": "10.1016/j.jmb.2025.169092", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9JAZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the class I amyloid-beta 42 fibril containing a D-Asp at position 23" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains FF,FG,FH,FI,FJ,FK,FL,FM,FN,FO,FP,FQ)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9JB1", "evidence_id": "EV-PDB-9JB1-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "9JB1", "doi": "10.1016/j.jmb.2025.169092", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9JB1" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the type I amyloid-beta 42 fibril containing a D-Asp at positions 7 and 23" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains B,F,K,L,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9K0D", "evidence_id": "EV-PDB-9K0D-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "9K0D", "doi": "10.1038/s41467-025-60978-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9K0D" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of Amyloid-beta42-4b polymorph 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains A,D,E,F,L,M)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9K0E", "evidence_id": "EV-PDB-9K0E-2", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "9K0E", "doi": "10.1038/s41467-025-60978-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9K0E" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of Amyloid-beta42-4b polymorph 2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,BA,BB,BC,BD,BE,C,CA,CB,CC,CD,CE,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9JB2", "evidence_id": "EV-PDB-9JB2-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "9JB2", "doi": "10.1016/j.jmb.2025.169092", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9JB2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the type II amyloid-beta 42 fibril containing a D-Asp at positions 7 and 23" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,AA,B,BB,C,CC,D,DD,E,EE,F,FF)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9JB0", "evidence_id": "EV-PDB-9JB0-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "9JB0", "doi": "10.1016/j.jmb.2025.169092", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9JB0" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the class II amyloid-beta 42 fibril containing a D-Asp at position 23" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FH2", "evidence_id": "EV-PDB-9FH2-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "9FH2", "doi": "10.1186/s40478-025-02120-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FH2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Beta-amyloid protein 42 (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CO4", "evidence_id": "EV-PDB-9CO4-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "9CO4", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CO4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the receptor-bound amyloid-beta 42 oligomer from human brain tissue (Conformation 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X)", "labels": [] }, "data_format": "mmCIF/IHM", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9A8E", "evidence_id": "EV-PDB-9A8E-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "9A8E", "doi": "10.1126/sciadv.adr7008", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9A8E" }, "reader": null, "source_kind": "deposit", "technique": "integrative", "title": "Type I Amyloid beta Fibril MEMMI ensemble" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CLR", "NAG", "PC1", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8X53", "evidence_id": "EV-PDB-8X53-5", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8X53", "doi": "10.1126/science.adn5820", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8X53" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human gamma-secretase in complex with Abeta46" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SEL", "evidence_id": "EV-PDB-8SEL-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "8SEL", "doi": "10.1038/s41594-024-01252-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SEL" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Type IIIb beta-amyloid 40 Filaments from Down Syndrome" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8SEJ", "evidence_id": "EV-PDB-8SEJ-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.17 }, "provenance": { "deposit_id": "8SEJ", "doi": "10.1038/s41594-024-01252-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8SEJ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Type I beta-amyloid 42 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"uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8OL2", "doi": "10.1038/s41593-023-01484-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OL2" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Murine type II Abeta fibril from APP23 mouse" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "P3(40) (chains A,B,C,D,E,F,G,H,I)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8KF6", "evidence_id": "EV-PDB-8KF6-1", "mappings": [], "molecule_id": "P05067", "observable": { 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"evidence_id": "EV-PDB-9WTW-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.98 }, "provenance": { "deposit_id": "9WTW", "doi": "10.1038/s41594-026-01855-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9WTW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Amyloid-beta 40 Flemish (A21G) mutant Filaments from Human Brain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9WAP", "evidence_id": "EV-PDB-9WAP-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.22 }, "provenance": { "deposit_id": "9WAP", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9WAP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of Type II Abeta fibrils from AppNL-FPsen1P117L mice" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 42 (chains A,B,C,D,E,F,G,H,I,J,K,L)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9WAO", "evidence_id": "EV-PDB-9WAO-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "9WAO", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9WAO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of type II Abeta fibrils from 5xFAD mice" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains Y,Z,a,b,c,d)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9W0Z", "evidence_id": "EV-PDB-9W0Z-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9W0Z", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9W0Z" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The cryo-EM structure of Apo_type1 abeta fibril." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1EUE" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains R,S,T,U,V,W,X,Y,Z,a,b,c)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9VXE", "evidence_id": "EV-PDB-9VXE-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9VXE", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9VXE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "The cryo-EM structure of NapIM_type1 amyloid beta 42 fibril." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains AL,AM,AN,AO,AP,AQ,AR,AS,AT,AU,AV,AW,AX,AY,AZ,Aa,Ab,Ac,Ad,Ae,Af)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UMH", "evidence_id": "EV-PDB-9UMH-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9UMH", "doi": "10.1021/acschemneuro.5c00217", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UMH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "V-type (V2-type) amyloid fibril (40) of Tottori (D7N) mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RIW", "evidence_id": "EV-PDB-9RIW-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "9RIW", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RIW" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Population A fibril generated from the Heterotypic interaction of Abeta40 and Medin." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9RIV", "evidence_id": "EV-PDB-9RIV-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.63 }, "provenance": { "deposit_id": "9RIV", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9RIV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Population B fibril generated from the Heterotypic interaction of Abeta40 and Medin." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9ONC", "evidence_id": "EV-PDB-9ONC-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.64 }, "provenance": { "deposit_id": "9ONC", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9ONC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "A-beta42-Met-R-SO amyloidal fibril - class3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta precursor protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9OBK", "evidence_id": "EV-PDB-9OBK-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.01 }, "provenance": { "deposit_id": "9OBK", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9OBK" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "A-beta42-Met-R-SO amyloidal fibril" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains 0,1,2,3,4,5,6,7,8,9,A,A0,A1,A2,A3,A4,A5,A6,A7,A8,A9,AA,AB,AC,AD,AE,AF,AG,AH,AI,AJ,AK,AL,AM,AN,AO,AP,AQ,AR,AS,AT,AU,AV,AW,AX,AY,AZ,Aa,Ab,Ac,Ad,Ae,Af,Ag,Ah,Ai,Aj,Ak,Al,Am,An,Ao,Ap,Aq,Ar,As,At,Au,Av,Aw,Ax,Ay,Az,B,BA,BB,BC,BD,BE,BF,BG,BH,BI,BJ,BK,BL,BM,BN,BO,BP,BQ,BR,BS,BT,BU,BV,BW,BX,BY,BZ,Ba,Bb,Bc,Bd,Be,Bf,Bg,Bh,Bi,Bj,Bk,Bl,Bm,Bn,Bo,Bp,Bq,Br,Bs,Bt,Bu,Bv,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f,g,h,i,j,k,l,m,n,o,p,q,r,s,t,u,v,w,x,y,z)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9M5R", "evidence_id": "EV-PDB-9M5R-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.6 }, "provenance": { "deposit_id": "9M5R", "doi": "10.1021/acschemneuro.5c00217", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9M5R" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ES-type (short pitch) amyloid fibril (40) of Tottori (D7N) mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains AL,AM,AN,AO,AP,AQ,AR,AS,AT,AU,AV,AW,AX,AY,AZ,Aa,Ab,Ac,Ad,Ae,Af)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9M5Q", "evidence_id": "EV-PDB-9M5Q-1", "mappings": [], "molecule_id": "P05067", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "9M5Q", "doi": "10.1021/acschemneuro.5c00217", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9M5Q" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "V-type (V1-type) amyloid fibril (40) of Tottori (D7N) mutant" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Amyloid-beta protein 40 (chains 1,2,3,4,5,6)", 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"temperature_c": 3.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=11435", "evidence_id": "EV-BMRB-11435", "mappings": [], "molecule_id": "P05067", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr11435", "doi": "10.13018/BMR11435", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=11435" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "1H, 13C, and 15N Chemical Shift Assignments for amyloid-beta-(1-40)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, 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"notes": "From the first sample condition list of the entry.", "ph": 7.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17159", "evidence_id": "EV-BMRB-17159", "mappings": [], "molecule_id": "P05067", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17159", "doi": "10.13018/BMR17159", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17159" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone assignment of the affibody-bound amyloid B-peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.3, "salt_mM": null, "temperature_c": 14.85 }, "construct": { "description": "BMRB data: 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17764", "evidence_id": "EV-BMRB-17764", "mappings": [], "molecule_id": "P05067", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17764", "doi": "10.13018/BMR17764", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17764" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "A partially folded structure of amyloid-beta(1 40) in an aqueous environment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.2, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17793", "evidence_id": "EV-BMRB-17793", "mappings": [], "molecule_id": "P05067", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17793", "doi": "10.13018/BMR17793", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17793" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone chemical shift assignments for Ab42 with Met35 in its oxidized state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.2, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17794", "evidence_id": "EV-BMRB-17794", "mappings": [], "molecule_id": "P05067", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17794", "doi": "10.13018/BMR17794", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17794" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone chemical shift assignments for Ab42 with Met35 in its reduced state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.2, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17795", "evidence_id": "EV-BMRB-17795", "mappings": [], "molecule_id": "P05067", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17795", "doi": "10.13018/BMR17795", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17795" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone chemical shift assignments for A 40 with Met35 in its oxidised state" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 7.2, "salt_mM": null, "temperature_c": -0.15 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17796", "evidence_id": "EV-BMRB-17796", "mappings": [], "molecule_id": "P05067", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17796", "doi": "10.13018/BMR17796", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17796" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Backbone chemical shift assignments for A 40 with Met35 in its reduced 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Dmax 6.51 nm.", "ph": 10.7, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Amyloid-beta precursor protein", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPR7/", "evidence_id": "EV-SASBDB-SASDPR7", "mappings": [], "molecule_id": "P05067", "observable": { "type": "radius_of_gyration", "uncertainty": 0.044, "unit": "nm", "value": 2.5 }, "provenance": { "deposit_id": "SASDPR7", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPR7/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation" }, { "conditions": { "applied_force_pn": null, "buffer": "1 mM Hepes, 0.1 % NH4OH (pH∼10.7)", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 9.11 nm.", "ph": 10.7, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Amyloid-beta precursor protein", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPS7/", "evidence_id": "EV-SASBDB-SASDPS7", "mappings": [], "molecule_id": "P05067", "observable": { "type": "radius_of_gyration", "uncertainty": 0.131, "unit": "nm", "value": 3.73 }, "provenance": { "deposit_id": "SASDPS7", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPS7/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation" }, { "conditions": { "applied_force_pn": null, "buffer": "1 mM Hepes, 0.1 % NH4OH (pH∼10.7)", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 11 nm.", "ph": 10.7, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Amyloid-beta precursor protein", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDPT7/", "evidence_id": "EV-SASBDB-SASDPT7", "mappings": [], "molecule_id": "P05067", "observable": { "type": "radius_of_gyration", "uncertainty": 0.362, "unit": "nm", "value": 3.73 }, "provenance": { "deposit_id": "SASDPT7", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDPT7/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Time-resolved small-angle X-ray scattering study of polymorphic nature of Aß42 oligomerisation" }, { "conditions": { "applied_force_pn": null, "buffer": "1 mM Hepes, 0.12 % NH4OH", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. 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