{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "saxs_sans", "cd", "fluorescence", "force_spectroscopy", "integrative", "af_prediction", "md" ], "unmapped_evidence": 388 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 39.85 }, "construct": { "description": "P53 (chains A,C)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1A1U", "evidence_id": "EV-PDB-1A1U-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1A1U", "doi": "10.1093/emboj/16.20.6230", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1A1U" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION STRUCTURE DETERMINATION OF A P53 MUTANT DIMERIZATION DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "P53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1AIE", "evidence_id": "EV-PDB-1AIE-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "1AIE", "doi": "10.1107/S0907444997006550", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1AIE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.8, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "P53 TUMOR SUPPRESSOR (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1C26", "evidence_id": "EV-PDB-1C26-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "1C26", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1C26" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains X,Y)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1DT7", "evidence_id": "EV-PDB-1DT7-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1DT7", "doi": "10.1038/76797", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1DT7" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1GZH", "evidence_id": "EV-PDB-1GZH-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1GZH", "doi": "10.1093/EMBOJ/CDF383", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1GZH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1GZH", "evidence_id": "EV-PDB-1GZH-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1GZH", "doi": "10.1093/EMBOJ/CDF383", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1GZH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1H26", "evidence_id": "EV-PDB-1H26-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.24 }, "provenance": { "deposit_id": "1H26", "doi": "10.1021/BI0268910", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1H26" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1HS5", "evidence_id": "EV-PDB-1HS5-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1HS5", "doi": "10.1006/jmbi.2001.4450", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1HS5" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "tumor protein p53 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1JSP", "evidence_id": "EV-PDB-1JSP-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1JSP", "doi": "10.1016/S1097-2765(03)00528-8", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1JSP" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR Structure of CBP Bromodomain in complex with p53 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MES", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1MA3", "evidence_id": "EV-PDB-1MA3-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "1MA3", "doi": "10.1016/S1097-2765(02)00628-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1MA3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of a Sir2 enzyme bound to an acetylated p53 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (OLIGOMERIZATION DOMAIN) (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1OLH", "evidence_id": "EV-PDB-1OLH-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1OLH", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1OLH" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1PES", "evidence_id": "EV-PDB-1PES-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1PES", "doi": "10.1038/nsb1294-877", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1PES" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1PET", "evidence_id": "EV-PDB-1PET-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1PET", "doi": "10.1038/nsb1294-877", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1PET" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SAE", "evidence_id": "EV-PDB-1SAE-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1SAE", "doi": "10.1038/nsb0495-321", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SAE" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SAF", "evidence_id": "EV-PDB-1SAF-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1SAF", "doi": "10.1038/nsb0495-321", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SAF" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SAK", "evidence_id": "EV-PDB-1SAK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1SAK", "doi": "10.1038/nsb0495-321", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SAK" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SAL", "evidence_id": "EV-PDB-1SAL-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1SAL", "doi": "10.1038/nsb0495-321", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SAL" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -175.15 }, "construct": { "description": "PROTEIN (P53 TUMOR SUPPRESSOR) (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1TSR", "evidence_id": "EV-PDB-1TSR-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1TSR", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1TSR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "P53 CORE DOMAIN IN COMPLEX WITH DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "PROTEIN (P53 TUMOR SUPPRESSOR ) (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1TUP", "evidence_id": "EV-PDB-1TUP-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1TUP", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1TUP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1UOL", "evidence_id": "EV-PDB-1UOL-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "1UOL", "doi": "10.1074/JBC.M309732200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1UOL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SAH" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "9-mer peptide from tumor protein p53 (chains B,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1XQH", "evidence_id": "EV-PDB-1XQH-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "1XQH", "doi": "10.1038/nature03117", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1XQH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NCA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.6, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1YC5", "evidence_id": "EV-PDB-1YC5-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "1YC5", "doi": "10.1016/j.molcel.2005.02.022", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1YC5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Sir2-p53 peptide-nicotinamide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "P53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1YCQ", "evidence_id": "EV-PDB-1YCQ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "1YCQ", "doi": "10.1126/science.274.5289.948", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1YCQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "P53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1YCR", "evidence_id": "EV-PDB-1YCR-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1YCR", "doi": "10.1126/science.274.5289.948", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1YCR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "P53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1YCS", "evidence_id": "EV-PDB-1YCS-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1YCS", "doi": "10.1126/science.274.5289.1001", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1YCS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "P53-53BP2 COMPLEX" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/21EX", "evidence_id": "EV-PDB-21EX-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.021 }, "provenance": { "deposit_id": "21EX", "doi": "10.1107/S2059798326007564", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/21EX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Wild tipe p53WT-HLA-A2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2ADY", "evidence_id": "EV-PDB-2ADY-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "2ADY", "doi": "10.1016/j.molcel.2006.05.015", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2ADY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural Basis of DNA Recognition by p53 Tetramers (complex IV)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2AHI", "evidence_id": "EV-PDB-2AHI-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "2AHI", "doi": "10.1016/j.molcel.2006.05.015", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2AHI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural Basis of DNA Recognition by p53 Tetramers (complex III)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.7, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2ATA", "evidence_id": "EV-PDB-2ATA-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "2ATA", "doi": "10.1016/j.molcel.2006.05.015", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2ATA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural Basis of DNA Recognition by p53 Tetramers (complex II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.9, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2B3G", "evidence_id": "EV-PDB-2B3G-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2B3G", "doi": "10.1073/pnas.0504614102", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2B3G" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53N (fragment 33-60) bound to RPA70N" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BIM", "evidence_id": "EV-PDB-2BIM-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.98 }, "provenance": { "deposit_id": "2BIM", "doi": "10.1074/JBC.M500179200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BIM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BIN", "evidence_id": "EV-PDB-2BIN-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2BIN", "doi": "10.1074/JBC.M500179200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BIN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BIO", "evidence_id": "EV-PDB-2BIO-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2BIO", "doi": "10.1074/JBC.M500179200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BIO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BIP", "evidence_id": "EV-PDB-2BIP-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "2BIP", "doi": "10.1074/JBC.M500179200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BIP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2BIQ", "evidence_id": "EV-PDB-2BIQ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "2BIQ", "doi": "10.1074/JBC.M500179200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2BIQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "p53 peptide (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FOJ", "evidence_id": "EV-PDB-2FOJ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2FOJ", "doi": "10.1038/nsmb1067", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FOJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "p53 peptide (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FOO", "evidence_id": "EV-PDB-2FOO-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "2FOO", "doi": "10.1038/nsmb1067", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FOO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2GS0", "evidence_id": "EV-PDB-2GS0-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2GS0", "doi": "10.1016/j.molcel.2006.05.007", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2GS0" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -73.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains M,N,O,P,Q,R,S,T,U,V,W,X)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2H1L", "evidence_id": "EV-PDB-2H1L-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.16 }, "provenance": { "deposit_id": "2H1L", "doi": "10.1101/gad.1456306", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2H1L" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2H2D", "evidence_id": "EV-PDB-2H2D-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "2H2D", "doi": "10.1021/bi0526332", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2H2D" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The Structural Basis for Sirtuin Substrate Affinity" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAD", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.6, "salt_mM": null, "temperature_c": -195.79 }, "construct": { "description": "Cellular tumor antigen p53 (chains D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2H4F", "evidence_id": "EV-PDB-2H4F-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "2H4F", "doi": "10.1016/j.str.2006.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2H4F" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Sir2-p53 peptide-NAD+" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NCA", "OAD", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2H4J", "evidence_id": "EV-PDB-2H4J-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "2H4J", "doi": "10.1016/j.str.2006.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2H4J" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Sir2-deacetylated peptide (from enzymatic turnover in crystal)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "3OD", "APR", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains D,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2H59", "evidence_id": "EV-PDB-2H59-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2H59", "doi": "10.1016/j.str.2006.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2H59" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J0Z", "evidence_id": "EV-PDB-2J0Z-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2J0Z", "doi": "10.1002/prot.21854", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J0Z" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "p53 tetramerization domain wild type" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J10", "evidence_id": "EV-PDB-2J10-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2J10", "doi": "10.1002/prot.21854", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J10" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "p53 tetramerization domain mutant T329F Q331K" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAD", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2H4H", "evidence_id": "EV-PDB-2H4H-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.99 }, "provenance": { "deposit_id": "2H4H", "doi": "10.1016/j.str.2006.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2H4H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Sir2 H116Y mutant-p53 peptide-NAD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2H2F", "evidence_id": "EV-PDB-2H2F-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "2H2F", "doi": "10.1021/bi0526332", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2H2F" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The Structural basis for Sirtuin Substrate affinity" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.1, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2FEJ", "evidence_id": "EV-PDB-2FEJ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2FEJ", "doi": "10.1073/pnas.0510941103", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2FEJ" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of human p53 DNA binding domain." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2AC0", "evidence_id": "EV-PDB-2AC0-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "2AC0", "doi": "10.1016/j.molcel.2006.05.015", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2AC0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural Basis of DNA Recognition by p53 Tetramers (complex I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "TUMOR SUPPRESSOR P53 (OLIGOMERIZATION DOMAIN) (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1OLG", "evidence_id": "EV-PDB-1OLG-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1OLG", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1OLG" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -170.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1KZY", "evidence_id": "EV-PDB-1KZY-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "1KZY", "doi": "10.1101/gad.959202", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1KZY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J11", "evidence_id": "EV-PDB-2J11-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2J11", "doi": "10.1002/prot.21854", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J11" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "p53 tetramerization domain mutant Y327S T329G Q331G" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J1W", "evidence_id": "EV-PDB-2J1W-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "2J1W", "doi": "10.1073/PNAS.0607286103", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J1W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J1X", "evidence_id": "EV-PDB-2J1X-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "2J1X", "doi": "10.1073/PNAS.0607286103", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J1X" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J1Z", "evidence_id": "EV-PDB-2J1Z-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "2J1Z", "doi": "10.1073/PNAS.0607286103", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J1Z" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J20", "evidence_id": "EV-PDB-2J20-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "2J20", "doi": "10.1073/PNAS.0607286103", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J20" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J21", "evidence_id": "EV-PDB-2J21-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2J21", "doi": "10.1073/PNAS.0607286103", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J21" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": 34.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K8F", "evidence_id": "EV-PDB-2K8F-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K8F", "doi": "10.1016/j.str.2008.12.009", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K8F" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structural Basis for the Regulation of p53 Function by p300" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2L14", "evidence_id": "EV-PDB-2L14-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2L14", "doi": "10.1021/bi1012996", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2L14" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure of CBP nuclear coactivator binding domain in complex with p53 TAD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LY4", "evidence_id": "EV-PDB-2LY4-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LY4", "doi": "10.1016/j.str.2012.09.004", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LY4" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MWO", "evidence_id": "EV-PDB-2MWO-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MWO", "doi": "10.1016/j.str.2014.11.013", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MWO" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2PCX", "evidence_id": "EV-PDB-2PCX-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.54 }, "provenance": { "deposit_id": "2PCX", "doi": "10.1107/S0907444908003338", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2PCX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53DBD(R282Q) at 1.54-angstrom Resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "PEPTIDIC SUBSTRATE (chains I,L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2V5W", "evidence_id": "EV-PDB-2V5W-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "2V5W", "doi": "10.1038/SJ.EMBOR.7401047", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2V5W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of HDAC8-substrate complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P83", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2VUK", "evidence_id": "EV-PDB-2VUK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "2VUK", "doi": "10.1073/PNAS.0805326105", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2VUK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2WGX", "evidence_id": "EV-PDB-2WGX-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.75 }, "provenance": { "deposit_id": "2WGX", "doi": "10.1093/PROTEIN/GZP018", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2WGX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "X0U", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2X0U", "evidence_id": "EV-PDB-2X0U-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "2X0U", "doi": "10.1016/J.CHEMBIOL.2009.12.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2X0U" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "X0V", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2X0V", "evidence_id": "EV-PDB-2X0V-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "2X0V", "doi": "10.1016/J.CHEMBIOL.2009.12.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2X0V" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "X0W", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2X0W", "evidence_id": "EV-PDB-2X0W-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "2X0W", "doi": "10.1016/J.CHEMBIOL.2009.12.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2X0W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2XWR", "evidence_id": "EV-PDB-2XWR-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.68 }, "provenance": { "deposit_id": "2XWR", "doi": "10.1016/J.JMB.2011.03.047", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2XWR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the DNA-binding domain of human p53 with extended N terminus" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2YBG", "evidence_id": "EV-PDB-2YBG-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2YBG", "doi": "10.1073/PNAS.1105028108", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2YBG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Lys120-acetylated p53 core domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -183.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P,Q,R)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2Z5S", "evidence_id": "EV-PDB-2Z5S-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "2Z5S", "doi": "10.4161/cc.6.19.4740", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2Z5S" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Molecular basis for the inhibition of p53 by Mdmx" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -183.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P,Q,R)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2Z5T", "evidence_id": "EV-PDB-2Z5T-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "2Z5T", "doi": "10.4161/cc.6.19.4740", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2Z5T" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Molecular basis for the inhibition of p53 by Mdmx" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains AAA,BBB)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/37ZA", "evidence_id": "EV-PDB-37ZA-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.11 }, "provenance": { "deposit_id": "37ZA", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/37ZA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of TP53 (89-293, Y220C)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D05", "evidence_id": "EV-PDB-3D05-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "3D05", "doi": "10.1016/j.jmb.2008.10.063", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D05" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R249S (II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D06", "evidence_id": "EV-PDB-3D06-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.2 }, "provenance": { "deposit_id": "3D06", "doi": "10.1016/j.jmb.2008.10.063", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D06" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R249S (I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D07", "evidence_id": "EV-PDB-3D07-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "3D07", "doi": "10.1016/j.jmb.2008.10.063", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D07" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R249S (III)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D08", "evidence_id": "EV-PDB-3D08-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "3D08", "doi": "10.1016/j.jmb.2008.10.063", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D08" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D09", "evidence_id": "EV-PDB-3D09-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "3D09", "doi": "10.1016/j.jmb.2008.10.063", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D09" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3D0A", "evidence_id": "EV-PDB-3D0A-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3D0A", "doi": "10.1016/j.jmb.2008.10.063", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3D0A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B,D,F,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3DAB", "evidence_id": "EV-PDB-3DAB-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "3DAB", "doi": "10.4161/cc.6365", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3DAB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IGK", "evidence_id": "EV-PDB-3IGK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "3IGK", "doi": "10.1038/nsmb.1800", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IGK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3IGL", "evidence_id": "EV-PDB-3IGL-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3IGL", "doi": "10.1038/nsmb.1800", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3IGL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.68, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3KMD", "evidence_id": "EV-PDB-3KMD-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.15 }, "provenance": { "deposit_id": "3KMD", "doi": "10.1016/j.str.2009.11.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3KMD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "IOD", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3KZ8", "evidence_id": "EV-PDB-3KZ8-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.91 }, "provenance": { "deposit_id": "3KZ8", "doi": "10.1038/nsmb.1800", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3KZ8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "peptide of Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3LW1", "evidence_id": "EV-PDB-3LW1-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.28 }, "provenance": { "deposit_id": "3LW1", "doi": "10.1016/j.febslet.2010.02.065", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3LW1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Binary complex of 14-3-3 sigma and p53 pT387-peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains D,E)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3OQ5", "evidence_id": "EV-PDB-3OQ5-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5005 }, "provenance": { "deposit_id": "3OQ5", "doi": "10.1074/jbc.M110.139527", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3OQ5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 18-residue peptide (chains D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PDH", "evidence_id": "EV-PDB-3PDH-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3PDH", "doi": "10.1002/pro.544", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PDH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Sir2Tm bound to a propionylated peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -188.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3Q01", "evidence_id": "EV-PDB-3Q01-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "3Q01", "doi": "10.1038/emboj.2011.127", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3Q01" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -188.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3Q05", "evidence_id": "EV-PDB-3Q05-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "3Q05", "doi": "10.1038/emboj.2011.127", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3Q05" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -188.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3Q06", "evidence_id": "EV-PDB-3Q06-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "3Q06", "doi": "10.1038/emboj.2011.127", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3Q06" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 34.85 }, "construct": { "description": "PROTEIN (TUMOR SUPPRESSOR P53) (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3SAK", "evidence_id": "EV-PDB-3SAK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "3SAK", "doi": "10.1021/ja9843730", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3SAK" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B,P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3DAC", "evidence_id": "EV-PDB-3DAC-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3DAC", "doi": "10.4161/cc.6365", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3DAC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1DRM", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains AAA,BBB)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/37ZR", "evidence_id": "EV-PDB-37ZR-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.39 }, "provenance": { "deposit_id": "37ZR", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/37ZR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of TP53 (89-293, Y220C) bound to compound 3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CD", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2YDR", "evidence_id": "EV-PDB-2YDR-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.75 }, "provenance": { "deposit_id": "2YDR", "doi": "10.1016/J.CHEMBIOL.2012.01.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2YDR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CpOGA D298N in complex with p53-derived O-GlcNAc peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 31.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2RUK", "evidence_id": "EV-PDB-2RUK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2RUK", "doi": "10.1021/ja506351f", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2RUK" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "P53 TUMOR SUPPRESSOR (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2OCJ", "evidence_id": "EV-PDB-2OCJ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.05 }, "provenance": { "deposit_id": "2OCJ", "doi": "10.1107/S0907444906048499", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2OCJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain in the absence of DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": 34.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MZD", "evidence_id": "EV-PDB-2MZD-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MZD", "doi": "10.1021/acs.biochem.5b00044", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MZD" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MWY", "evidence_id": "EV-PDB-2MWY-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MWY", "doi": "10.1016/j.jmb.2016.01.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MWY" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Mdmx-p53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MWP", "evidence_id": "EV-PDB-2MWP-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MWP", "doi": "10.1016/j.str.2014.11.013", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MWP" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MEJ", "evidence_id": "EV-PDB-2MEJ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MEJ", "doi": "10.1038/nsmb.2829", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MEJ" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2J1Y", "evidence_id": "EV-PDB-2J1Y-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.69 }, "provenance": { "deposit_id": "2J1Y", "doi": "10.1073/PNAS.0607286103", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2J1Y" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL", "SAH", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3TG5", "evidence_id": "EV-PDB-3TG5-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "3TG5", "doi": "10.1074/jbc.M111.262410", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3TG5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of SMYD2 in complex with p53 and SAH" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -188.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3TS8", "evidence_id": "EV-PDB-3TS8-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "3TS8", "doi": "10.1158/1541-7786.MCR-11-0351", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3TS8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "QC5", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3ZME", "evidence_id": "EV-PDB-3ZME-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "3ZME", "doi": "10.1093/nar/gkt305", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3ZME" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P84", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4AGL", "evidence_id": "EV-PDB-4AGL-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "4AGL", "doi": "10.1021/JA301056A", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4AGL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P86", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4AGM", "evidence_id": "EV-PDB-4AGM-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.52 }, "provenance": { "deposit_id": "4AGM", "doi": "10.1021/JA301056A", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4AGM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NXG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4AGN", "evidence_id": "EV-PDB-4AGN-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "4AGN", "doi": "10.1021/JA301056A", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4AGN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5116" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P74", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4AGO", "evidence_id": "EV-PDB-4AGO-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.45 }, "provenance": { "deposit_id": "4AGO", "doi": "10.1021/JA301056A", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4AGO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P51", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4AGP", "evidence_id": "EV-PDB-4AGP-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "4AGP", "doi": "10.1021/JA301056A", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4AGP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "P96", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4AGQ", "evidence_id": "EV-PDB-4AGQ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.42 }, "provenance": { "deposit_id": "4AGQ", "doi": "10.1021/JA301056A", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4AGQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "NAD", "OAD", "OCZ", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4BUZ", "evidence_id": "EV-PDB-4BUZ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "4BUZ", "doi": "10.1073/PNAS.1303628110", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4BUZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "OAD", "OCZ", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.9, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains E,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4BV2", "evidence_id": "EV-PDB-4BV2-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "4BV2", "doi": "10.1073/PNAS.1303628110", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4BV2" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "peptide from Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4FZ3", "evidence_id": "EV-PDB-4FZ3-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "4FZ3", "doi": "10.1021/jm301032j", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4FZ3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 22.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4HFZ", "evidence_id": "EV-PDB-4HFZ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.694 }, "provenance": { "deposit_id": "4HFZ", "doi": "10.1107/S0907444913004459", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4HFZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of an MDM2/P53 Peptide Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4HJE", "evidence_id": "EV-PDB-4HJE-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.907 }, "provenance": { "deposit_id": "4HJE", "doi": "10.1093/nar/gkt584", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4HJE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 core domain in complex with DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBQ", "evidence_id": "EV-PDB-4IBQ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "4IBQ", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBS", "evidence_id": "EV-PDB-4IBS-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.78 }, "provenance": { "deposit_id": "4IBS", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273H (form I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBT", "evidence_id": "EV-PDB-4IBT-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "4IBT", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBU", "evidence_id": "EV-PDB-4IBU-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "4IBU", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R in sequence-specific complex with DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBV", "evidence_id": "EV-PDB-4IBV-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "4IBV", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBW", "evidence_id": "EV-PDB-4IBW-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.791 }, "provenance": { "deposit_id": "4IBW", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R in sequence-specific complex with DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBY", "evidence_id": "EV-PDB-4IBY-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.45 }, "provenance": { "deposit_id": "4IBY", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation S240R" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IBZ", "evidence_id": "EV-PDB-4IBZ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.92 }, "provenance": { "deposit_id": "4IBZ", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IBZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "DTT", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4IJT", "evidence_id": "EV-PDB-4IJT-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.78 }, "provenance": { "deposit_id": "4IJT", "doi": "10.1093/nar/gkt630", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4IJT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R273H (form II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4KVP", "evidence_id": "EV-PDB-4KVP-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "4KVP", "doi": "10.1107/S0907444913020830", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4KVP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 Core Domain Mutant V157F" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LO9", "evidence_id": "EV-PDB-4LO9-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "4LO9", "doi": "10.1107/S0907444913020830", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LO9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 Core Domain Mutant N235K" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LOE", "evidence_id": "EV-PDB-4LOE-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "4LOE", "doi": "10.1107/S0907444913020830", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LOE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 Core Domain Mutant N239Y" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4LOF", "evidence_id": "EV-PDB-4LOF-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "4LOF", "doi": "10.1107/S0907444913020830", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4LOF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 Core Domain Mutant V157F/N235K/N239Y" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": -188.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4MZI", "evidence_id": "EV-PDB-4MZI-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.25 }, "provenance": { "deposit_id": "4MZI", "doi": "10.1016/j.jmb.2013.12.020", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4MZI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a human mutant p53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -188.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4MZR", "evidence_id": "EV-PDB-4MZR-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "4MZR", "doi": "10.1016/j.jmb.2013.12.020", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4MZR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a polypeptide p53 mutant bound to DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4QO1", "evidence_id": "EV-PDB-4QO1-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.924 }, "provenance": { "deposit_id": "4QO1", "doi": "10.1093/nar/gku962", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4QO1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 DNA binding domain in complex with Nb139" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "LTIITLE heptapeptide segment from p53 (chains Z)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4RP6", "evidence_id": "EV-PDB-4RP6-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.703 }, "provenance": { "deposit_id": "4RP6", "doi": "10.1016/j.ccell.2015.12.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4RP6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "THR-SER-ARG-HIS-ALY-MLY-LEU-MET-PHE-LYS (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4X34", "evidence_id": "EV-PDB-4X34-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.801 }, "provenance": { "deposit_id": "4X34", "doi": "10.1016/j.str.2014.12.010", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4X34" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "PEG", "ZN", "branched: alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4XR8", "evidence_id": "EV-PDB-4XR8-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.25 }, "provenance": { "deposit_id": "4XR8", "doi": "10.1038/nature16481", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4XR8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "4TQ", "CNA", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Ac-p53 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4ZZJ", "evidence_id": "EV-PDB-4ZZJ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.7403 }, "provenance": { "deposit_id": "4ZZJ", "doi": "10.1038/ncomms8645", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4ZZJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "SIRT1/Activator/Substrate Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "KMN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5A7B", "evidence_id": "EV-PDB-5A7B-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "5A7B", "doi": "10.1021/ACSCHEMBIO.5B00515", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5A7B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "92O", "PEG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AB9", "evidence_id": "EV-PDB-5AB9-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.36 }, "provenance": { "deposit_id": "5AB9", "doi": "10.1016/J.STR.2015.10.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AB9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "UL7", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5ABA", "evidence_id": "EV-PDB-5ABA-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.62 }, "provenance": { "deposit_id": "5ABA", "doi": "10.1016/J.STR.2015.10.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5ABA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PEG", "RZH", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AOI", "evidence_id": "EV-PDB-5AOI-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.78 }, "provenance": { "deposit_id": "5AOI", "doi": "10.1016/J.STR.2015.10.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AOI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C in complex with an indole- based small molecule" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PEG", "Y0V", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AOJ", "evidence_id": "EV-PDB-5AOJ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.47 }, "provenance": { "deposit_id": "5AOJ", "doi": "10.1016/J.STR.2015.10.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AOJ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOH", "GOL", "PEG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AOK", "evidence_id": "EV-PDB-5AOK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "5AOK", "doi": "10.1016/J.STR.2015.10.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AOK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan7099" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "UFV", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AOL", "evidence_id": "EV-PDB-5AOL-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "5AOL", "doi": "10.1016/J.STR.2015.10.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AOL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C with bound 3-bromo-5-(trifluoromethyl)benzene-1,2-diamine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FY8", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5AOM", "evidence_id": "EV-PDB-5AOM-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.74 }, "provenance": { "deposit_id": "5AOM", "doi": "10.1016/J.STR.2015.10.016", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5AOM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5BUA", "evidence_id": "EV-PDB-5BUA-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.812 }, "provenance": { "deposit_id": "5BUA", "doi": "10.1016/j.jmb.2016.06.009", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5BUA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Lysine 120-acetylated P53 DNA binding domain in a complex with DNA." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "GOL", "O82", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5G4M", "evidence_id": "EV-PDB-5G4M-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.38 }, "provenance": { "deposit_id": "5G4M", "doi": "10.1021/ACSCHEMBIO.6B00315", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5G4M" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the p53 cancer mutant Y220C in complex with a monofluorinated derivative of the small molecule stabilizer Phikan083" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL", "O83", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5G4N", "evidence_id": "EV-PDB-5G4N-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "5G4N", "doi": "10.1021/ACSCHEMBIO.6B00315", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5G4N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "O80", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "CELLULAR TUMOR ANTIGEN P53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5G4O", "evidence_id": "EV-PDB-5G4O-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.48 }, "provenance": { "deposit_id": "5G4O", "doi": "10.1021/ACSCHEMBIO.6B00315", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5G4O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the p53 cancer mutant Y220C in complex with a trifluorinated derivative of the small molecule stabilizer Phikan083" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 34.85 }, "construct": { "description": "Cellular tumor antigen p53,CREB-binding protein fusion protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5HOU", "evidence_id": "EV-PDB-5HOU-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5HOU", "doi": "10.1073/pnas.1602487113", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5HOU" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of p53TAD-TAZ1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 31.85 }, "construct": { "description": "CREB-binding protein,Cellular tumor antigen p53 fusion protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5HP0", "evidence_id": "EV-PDB-5HP0-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5HP0", "doi": "10.1073/pnas.1602487113", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5HP0" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of TAZ2-p53AD2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5ECG", "evidence_id": "EV-PDB-5ECG-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "5ECG", "doi": "10.1016/j.celrep.2015.10.074", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5ECG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "TIITLE hexapeptide segment from p53 (chains Z)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4RP7", "evidence_id": "EV-PDB-4RP7-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.576 }, "provenance": { "deposit_id": "4RP7", "doi": "10.1016/j.ccell.2015.12.002", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4RP7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.8, "salt_mM": null, "temperature_c": 31.85 }, "construct": { "description": "CREB-binding protein,Cellular tumor antigen p53 fusion protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5HPD", "evidence_id": "EV-PDB-5HPD-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "5HPD", "doi": "10.1073/pnas.1602487113", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5HPD" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution Structure of TAZ2-p53TAD" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5LGY", "evidence_id": "EV-PDB-5LGY-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.92 }, "provenance": { "deposit_id": "5LGY", "doi": "10.1016/j.jmb.2016.06.009", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5LGY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Lysine 120-acetylated P53 DNA binding domain in a complex with the BAX response element." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MCV", "evidence_id": "EV-PDB-5MCV-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "5MCV", "doi": "10.1016/j.str.2018.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MCV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FOR", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MCW", "evidence_id": "EV-PDB-5MCW-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.897 }, "provenance": { "deposit_id": "5MCW", "doi": "10.1016/j.str.2018.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MCW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MG7", "evidence_id": "EV-PDB-5MG7-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.45 }, "provenance": { "deposit_id": "5MG7", "doi": "10.1016/j.str.2018.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MG7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-p53R2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MHC", "evidence_id": "EV-PDB-5MHC-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.2 }, "provenance": { "deposit_id": "5MHC", "doi": "10.1002/1873-3468.12723", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MHC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "p53 C-terminal domain (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MOC", "evidence_id": "EV-PDB-5MOC-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "5MOC", "doi": "10.1002/1873-3468.12723", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MOC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9H5", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1A", "evidence_id": "EV-PDB-5O1A-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.44 }, "provenance": { "deposit_id": "5O1A", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB240" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9H2", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1B", "evidence_id": "EV-PDB-5O1B-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.43 }, "provenance": { "deposit_id": "5O1B", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB84" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9GZ", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1C", "evidence_id": "EV-PDB-5O1C-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.32 }, "provenance": { "deposit_id": "5O1C", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1C" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB184" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9GW", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1D", "evidence_id": "EV-PDB-5O1D-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.36 }, "provenance": { "deposit_id": "5O1D", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1D" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB481" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9GT", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1E", "evidence_id": "EV-PDB-5O1E-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.3 }, "provenance": { "deposit_id": "5O1E", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1E" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C im complex with compound MB577" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9GQ", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1F", "evidence_id": "EV-PDB-5O1F-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.38 }, "provenance": { "deposit_id": "5O1F", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1F" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB582" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9GK", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1G", "evidence_id": "EV-PDB-5O1G-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "5O1G", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1G" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB487" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9GN", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1H", "evidence_id": "EV-PDB-5O1H-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.32 }, "provenance": { "deposit_id": "5O1H", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB539" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "9GH", "EDO", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5O1I", "evidence_id": "EV-PDB-5O1I-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "5O1I", "doi": "10.1016/j.ejmech.2018.04.035", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5O1I" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with compound MB710" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "P53 peptide (chains E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5UN8", "evidence_id": "EV-PDB-5UN8-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.13 }, "provenance": { "deposit_id": "5UN8", "doi": "10.1038/nsmb.3390", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5UN8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of human O-GlcNAcase in complex with glycopeptide p53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains B,C,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5XZC", "evidence_id": "EV-PDB-5XZC-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 10.7 }, "provenance": { "deposit_id": "5XZC", "doi": "10.1021/acs.biochem.9b00333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5XZC" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of p300-p53 protein complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6FF9", "evidence_id": "EV-PDB-6FF9-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "6FF9", "doi": "10.3390/ijms19041184", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6FF9" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Mutant R280K of human P53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EY2", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GGA", "evidence_id": "EV-PDB-6GGA-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.55000123008 }, "provenance": { "deposit_id": "6GGA", "doi": "10.4155/fmc-2019-0181", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GGA" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9284" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "EPE", "EXQ", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GGB", "evidence_id": "EV-PDB-6GGB-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.32 }, "provenance": { "deposit_id": "6GGB", "doi": "10.4155/fmc-2019-0181", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GGB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9318" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "EXN", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GGC", "evidence_id": "EV-PDB-6GGC-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.24 }, "provenance": { "deposit_id": "6GGC", "doi": "10.4155/fmc-2019-0181", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GGC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9320" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EYB", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GGD", "evidence_id": "EV-PDB-6GGD-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4000088608 }, "provenance": { "deposit_id": "6GGD", "doi": "10.4155/fmc-2019-0181", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GGD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EYE", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GGE", "evidence_id": "EV-PDB-6GGE-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.25000506704 }, "provenance": { "deposit_id": "6GGE", "doi": "10.4155/fmc-2019-0181", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GGE" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EXQ", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GGF", "evidence_id": "EV-PDB-6GGF-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.32000022323 }, "provenance": { "deposit_id": "6GGF", "doi": "10.4155/fmc-2019-0181", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GGF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9328" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "fusion protein of Bcl-2-like protein 1 and Isoform 6 of Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6LHD", "evidence_id": "EV-PDB-6LHD-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.499 }, "provenance": { "deposit_id": "6LHD", "doi": "10.1038/s41467-021-22655-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6LHD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53/BCL-xL fusion complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "JT2", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "p53pT387 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6R5L", "evidence_id": "EV-PDB-6R5L-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.884 }, "provenance": { "deposit_id": "6R5L", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6R5L" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-006 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "K6B", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RJZ", "evidence_id": "EV-PDB-6RJZ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.58 }, "provenance": { "deposit_id": "6RJZ", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RJZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-015 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "K6T", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RKI", "evidence_id": "EV-PDB-6RKI-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.88 }, "provenance": { "deposit_id": "6RKI", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RKI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-023 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "K6Z", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RKM", "evidence_id": "EV-PDB-6RKM-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.88 }, "provenance": { "deposit_id": "6RKM", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RKM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-022 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "K48", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RL3", "evidence_id": "EV-PDB-6RL3-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.3 }, "provenance": { "deposit_id": "6RL3", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RL3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-003 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "K7N", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RL4", "evidence_id": "EV-PDB-6RL4-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "6RL4", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RL4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-025 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "K7Q", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RL6", "evidence_id": "EV-PDB-6RL6-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "6RL6", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RL6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-024 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "K8W", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RM5", "evidence_id": "EV-PDB-6RM5-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.884 }, "provenance": { "deposit_id": "6RM5", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RM5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-016 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "K92", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RM7", "evidence_id": "EV-PDB-6RM7-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "6RM7", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RM7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-026 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "KLB", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RWH", "evidence_id": "EV-PDB-6RWH-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.68 }, "provenance": { "deposit_id": "6RWH", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RWH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-007 binding at a primary and secondary binding site of the the p53pT387/14-3-3 sigma complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "KLE", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RWI", "evidence_id": "EV-PDB-6RWI-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.65 }, "provenance": { "deposit_id": "6RWI", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RWI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-002 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "KLZ", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RWS", "evidence_id": "EV-PDB-6RWS-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.53 }, "provenance": { "deposit_id": "6RWS", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RWS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-009 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "KM8" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RWU", "evidence_id": "EV-PDB-6RWU-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.46 }, "provenance": { "deposit_id": "6RWU", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RWU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-010 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "KM2", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RX2", "evidence_id": "EV-PDB-6RX2-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.82 }, "provenance": { "deposit_id": "6RX2", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RX2" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-005 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RZ3", "evidence_id": "EV-PDB-6RZ3-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.23 }, "provenance": { "deposit_id": "6RZ3", "doi": "10.1073/pnas.1909393116", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RZ3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "K5Z" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6S39", "evidence_id": "EV-PDB-6S39-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.88 }, "provenance": { "deposit_id": "6S39", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6S39" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-018 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "K6W", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RKK", "evidence_id": "EV-PDB-6RKK-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.88 }, "provenance": { "deposit_id": "6RKK", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RKK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-021 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "K6N", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RK8", "evidence_id": "EV-PDB-6RK8-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.602 }, "provenance": { "deposit_id": "6RK8", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RK8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-014 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6FJ5", "evidence_id": "EV-PDB-6FJ5-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.051 }, "provenance": { "deposit_id": "6FJ5", "doi": "10.1016/j.str.2018.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6FJ5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-AGG-HG)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5OL0", "evidence_id": "EV-PDB-5OL0-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.99 }, "provenance": { "deposit_id": "5OL0", "doi": "10.1371/journal.pone.0193602", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5OL0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSIR2rp1) in complex with acetylated p53 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PEG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MF7", "evidence_id": "EV-PDB-5MF7-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.59 }, "provenance": { "deposit_id": "5MF7", "doi": "10.1016/j.str.2018.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MF7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-GADD45)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MCU", "evidence_id": "EV-PDB-5MCU-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "5MCU", "doi": "10.1016/j.str.2018.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MCU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "FOR", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5MCT", "evidence_id": "EV-PDB-5MCT-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.446 }, "provenance": { "deposit_id": "5MCT", "doi": "10.1016/j.str.2018.06.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5MCT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "6SM", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5LAP", "evidence_id": "EV-PDB-5LAP-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.42 }, "provenance": { "deposit_id": "5LAP", "doi": "10.1073/pnas.1610421113", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5LAP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C with Cys182 alkylation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "GOL", "KDK", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "p53pT387 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6S3C", "evidence_id": "EV-PDB-6S3C-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "6S3C", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6S3C" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-019 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CL", "GOL", "KTW", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "p53pT387 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6S40", "evidence_id": "EV-PDB-6S40-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "6S40", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6S40" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-001 binding at the p53pT387/14-3-3 sigma interface and additional sites" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "L1T" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6S9Q", "evidence_id": "EV-PDB-6S9Q-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.69 }, "provenance": { "deposit_id": "6S9Q", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6S9Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-004 binding at a primary and secondary site in a p53pT387/14-3-3 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SHZ", "evidence_id": "EV-PDB-6SHZ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.24 }, "provenance": { "deposit_id": "6SHZ", "doi": "10.1021/acschembio.9b00748", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SHZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "EPE", "GOL", "LEK", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SI0", "evidence_id": "EV-PDB-6SI0-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.53 }, "provenance": { "deposit_id": "6SI0", "doi": "10.1021/acschembio.9b00748", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SI0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9323" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "EPE", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SI1", "evidence_id": "EV-PDB-6SI1-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.44 }, "provenance": { "deposit_id": "6SI1", "doi": "10.1021/acschembio.9b00748", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SI1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220H" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SI2", "evidence_id": "EV-PDB-6SI2-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "6SI2", "doi": "10.1021/acschembio.9b00748", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SI2" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220S" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "GOL", "LEB", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SI3", "evidence_id": "EV-PDB-6SI3-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "6SI3", "doi": "10.1021/acschembio.9b00748", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SI3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL", "LEK", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SI4", "evidence_id": "EV-PDB-6SI4-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "6SI4", "doi": "10.1021/acschembio.9b00748", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SI4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K65" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SIN", "evidence_id": "EV-PDB-6SIN-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.64 }, "provenance": { "deposit_id": "6SIN", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SIN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-020 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "LFQ", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SIO", "evidence_id": "EV-PDB-6SIO-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.60418 }, "provenance": { "deposit_id": "6SIO", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SIO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-017 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "LFB", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SIP", "evidence_id": "EV-PDB-6SIP-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6004470265 }, "provenance": { "deposit_id": "6SIP", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SIP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-011 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "LF5" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SIQ", "evidence_id": "EV-PDB-6SIQ-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.60121 }, "provenance": { "deposit_id": "6SIQ", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SIQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-012 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SL6", "evidence_id": "EV-PDB-6SL6-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.67 }, "provenance": { "deposit_id": "6SL6", "doi": "10.1016/j.celrep.2020.03.076", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SL6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 charged core" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "LJW", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SLV", "evidence_id": "EV-PDB-6SLV-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "6SLV", "doi": "10.1021/acs.jmedchem.9b01942", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SLV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment AZ-013 binding at the p53pT387/14-3-3 sigma interface" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Stapled Peptide LSQETF(0EH)DLWKLE(MK8)EN(NH2) (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6V4F", "evidence_id": "EV-PDB-6V4F-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.35 }, "provenance": { "deposit_id": "6V4F", "doi": "10.1016/j.str.2020.04.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6V4F" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure Analysis of Zebra Fish MDMX" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Stapled Peptide LSQETF(0EH)DLWKLL(MK8)EN(NH2) (chains B,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6V4H", "evidence_id": "EV-PDB-6V4H-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.53 }, "provenance": { "deposit_id": "6V4H", "doi": "10.1016/j.str.2020.04.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6V4H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure Analysis of Zebra Fish MDMX" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "peptide from p53 tumor suppressor (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6VQO", "evidence_id": "EV-PDB-6VQO-5", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "6VQO", "doi": "10.1038/s41467-020-16755-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6VQO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "T cell receptor-p53-HLA-A2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6VR1", "evidence_id": "EV-PDB-6VR1-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.37 }, "provenance": { "deposit_id": "6VR1", "doi": "10.1038/s41467-020-16755-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6VR1" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Complex of HLA-A2, a class I MHC, with a p53 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains P,Q)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6VR5", "evidence_id": "EV-PDB-6VR5-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.38 }, "provenance": { "deposit_id": "6VR5", "doi": "10.1038/s41467-020-16755-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6VR5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Complex of HLA-A2, a class I MHC, with a p53 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6VRM", "evidence_id": "EV-PDB-6VRM-5", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.61 }, "provenance": { "deposit_id": "6VRM", "doi": "10.1038/s41467-020-16755-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6VRM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "T cell receptor-p53-HLA-A2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.7, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6VRN", "evidence_id": "EV-PDB-6VRN-5", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.46 }, "provenance": { "deposit_id": "6VRN", "doi": "10.1038/s41467-020-16755-y", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6VRN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "T cell receptor-p53-HLA-A2 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains C,F,I,L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6W51", "evidence_id": "EV-PDB-6W51-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.53 }, "provenance": { "deposit_id": "6W51", "doi": "10.1126/science.abc8697", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6W51" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains M)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6XRE", "evidence_id": "EV-PDB-6XRE-13", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.6 }, "provenance": { "deposit_id": "6XRE", "doi": "10.1038/s42003-021-01934-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6XRE" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of the p53/RNA polymerase II assembly" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6ZNC", "evidence_id": "EV-PDB-6ZNC-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.64 }, "provenance": { "deposit_id": "6ZNC", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6ZNC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B46", "evidence_id": "EV-PDB-7B46-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.02 }, "provenance": { "deposit_id": "7B46", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B46" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (P1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B47", "evidence_id": "EV-PDB-7B47-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "7B47", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B47" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "EDO", "PEG", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B48", "evidence_id": "EV-PDB-7B48-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.05 }, "provenance": { "deposit_id": "7B48", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B48" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "EDO", "FMT", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B49", "evidence_id": "EV-PDB-7B49-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.42 }, "provenance": { "deposit_id": "7B49", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B49" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FMT", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4A", "evidence_id": "EV-PDB-7B4A-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "7B4A", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "PEG", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4B", "evidence_id": "EV-PDB-7B4B-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.76 }, "provenance": { "deposit_id": "7B4B", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "PEG", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4C", "evidence_id": "EV-PDB-7B4C-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.71 }, "provenance": { "deposit_id": "7B4C", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4C" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FMT", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4D", "evidence_id": "EV-PDB-7B4D-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "7B4D", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4D" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "PG4", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4E", "evidence_id": "EV-PDB-7B4E-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.58 }, "provenance": { "deposit_id": "7B4E", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4E" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FMT", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4F", "evidence_id": "EV-PDB-7B4F-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.78 }, "provenance": { "deposit_id": "7B4F", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4F" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "PEG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4G", "evidence_id": "EV-PDB-7B4G-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.86 }, "provenance": { "deposit_id": "7B4G", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4G" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "EDO", "FMT", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4H", "evidence_id": "EV-PDB-7B4H-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.39 }, "provenance": { "deposit_id": "7B4H", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "FMT", "QN8", "QNN", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7B4N", "evidence_id": "EV-PDB-7B4N-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.32 }, "provenance": { "deposit_id": "7B4N", "doi": "10.1038/s41467-021-27142-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7B4N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Chimera of Green fluorescent protein and p53dim (chains A,C,E,F,H,J,M,O)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7BWN", "evidence_id": "EV-PDB-7BWN-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.396 }, "provenance": { "deposit_id": "7BWN", "doi": "10.1002/anie.202005490", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7BWN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of a Designed Protein Heterocatenane" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains B,D,G,I,K,L,N,P)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7BWN", "evidence_id": "EV-PDB-7BWN-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.396 }, "provenance": { "deposit_id": "7BWN", "doi": "10.1002/anie.202005490", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7BWN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of a Designed Protein Heterocatenane" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ARS", "GOL", "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DHY", "evidence_id": "EV-PDB-7DHY-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.15 }, "provenance": { "deposit_id": "7DHY", "doi": "10.1016/j.ccell.2020.11.013", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DHY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Arsenic-bound p53 DNA-binding domain mutant G245S" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ARS", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DHZ", "evidence_id": "EV-PDB-7DHZ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.74 }, "provenance": { "deposit_id": "7DHZ", "doi": "10.1016/j.ccell.2020.11.013", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DHZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Arsenic-bound p53 DNA-binding domain mutant R249S" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7DVD", "evidence_id": "EV-PDB-7DVD-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.59 }, "provenance": { "deposit_id": "7DVD", "doi": "10.1016/j.bbrc.2021.02.049", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7DVD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The crystal structure of p53 DNA binding domain and PUMA complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SB", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EAX", "evidence_id": "EV-PDB-7EAX-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.55 }, "provenance": { "deposit_id": "7EAX", "doi": "10.1016/j.celrep.2022.110622", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EAX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal complex of p53-V272M and antimony ion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ARS", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + 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}, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D,E,F,G,H)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EEU", "evidence_id": "EV-PDB-7EEU-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "7EEU", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EEU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 core domain with hot spot mutation R282W in complex with the natural CDKN1A(p21) p53-response element and Arsenic" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MG", "O4B" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.16, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53,Protein Mdm4 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EL4", "evidence_id": "EV-PDB-7EL4-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.11 }, "provenance": { "deposit_id": "7EL4", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EL4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The crystal structure of p53p peptide fragment in complex with the N-terminal domain of MdmX" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7NMI", "evidence_id": "EV-PDB-7NMI-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "7NMI", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7NMI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 peptide (chains C,H,M,R)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RM4", "evidence_id": "EV-PDB-7RM4-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.33 }, "provenance": { "deposit_id": "7RM4", "doi": "10.1016/j.jbc.2022.101684", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RM4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ARS", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7V97", "evidence_id": "EV-PDB-7V97-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.02 }, "provenance": { "deposit_id": "7V97", "doi": "10.1126/scitranslmed.abn9155", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7V97" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Arsenic-bound p53 DNA-binding domain mutant V272M" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53,Protein S100-A4,Protein S100-A4,Annexin A2 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6T58", "evidence_id": "EV-PDB-6T58-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "6T58", "doi": "10.1016/j.str.2020.05.001", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6T58" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin A2 as a crystallization chaperone" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains K,L,M,N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7XZZ", "evidence_id": "EV-PDB-7XZZ-7", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.07 }, "provenance": { "deposit_id": "7XZZ", "doi": "10.1093/pnasnexus/pgac177", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7XZZ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of the nucleosome in complex with p53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "K", "NA", "PO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YGI", "evidence_id": "EV-PDB-7YGI-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "7YGI", "doi": "10.1038/s42003-023-04458-1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YGI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 DBD domain in complex with azurin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL", "KV0", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8A31", "evidence_id": "EV-PDB-8A31-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.46 }, "provenance": { "deposit_id": "8A31", "doi": "10.1021/acsptsci.2c00164", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8A31" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC694" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "GOL", "KVA", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8A32", "evidence_id": "EV-PDB-8A32-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.47 }, "provenance": { "deposit_id": "8A32", "doi": "10.1021/acsptsci.2c00164", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8A32" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC769" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EPE", "LE9", "PEG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.15, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8A92", "evidence_id": "EV-PDB-8A92-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.37 }, "provenance": { "deposit_id": "8A92", "doi": "10.1039/d2md00246a", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8A92" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53-Y220C Core Domain in Complex with a Bromo-trifluoro-pyrazole-amine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1IH3", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8CG7", "evidence_id": "EV-PDB-8CG7-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.53 }, "provenance": { "deposit_id": "8CG7", "doi": "10.1021/acs.bioconjchem.3c00322", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8CG7" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of p53 cancer mutant Y220C with arylation at Cys182 and Cys277" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "R3R", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DC4", "evidence_id": "EV-PDB-8DC4-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "8DC4", "doi": "10.1158/2159-8290.CD-22-0381", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DC4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 Y220C covalently bound to carbazole KG3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MG", "R4F", "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DC6", "evidence_id": "EV-PDB-8DC6-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.60000908706 }, "provenance": { "deposit_id": "8DC6", "doi": "10.1158/2159-8290.CD-22-0381", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DC6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 Y220C covalently 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"source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 Y220C covalently bound to indole KG10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MG", "R50", "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8DC8", "evidence_id": "EV-PDB-8DC8-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.72009735908 }, "provenance": { "deposit_id": "8DC8", "doi": "10.1158/2159-8290.CD-22-0381", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8DC8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 Y220C covalently bound to azaindole KG13" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 17.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8E7A", "evidence_id": "EV-PDB-8E7A-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.3 }, "provenance": { "deposit_id": "8E7A", "doi": "10.1158/2159-8290.CD-22-1315", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8E7A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the p53 (Y107H) core domain orthorhombic P form" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 17.85 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8E7B", "evidence_id": "EV-PDB-8E7B-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, 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"observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.38 }, "provenance": { "deposit_id": "8GCR", "doi": "10.1038/s41467-024-45920-w", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8GCR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "HPV16 E6-E6AP-p53 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8HLL", "evidence_id": "EV-PDB-8HLL-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.62 }, "provenance": { "deposit_id": "8HLL", "doi": "10.1038/s41467-023-40087-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8HLL" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53/BCL2 fusion complex (complex 1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8HLM", "evidence_id": "EV-PDB-8HLM-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.522 }, "provenance": { "deposit_id": "8HLM", "doi": "10.1038/s41467-023-40087-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8HLM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53/BCL2 fusion complex (complex 2)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8J8N", "evidence_id": "EV-PDB-8J8N-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 9.02 }, "provenance": { "deposit_id": "8J8N", "doi": "10.1016/j.ijbiomac.2024.133314", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8J8N" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of p53 DNA-binding domain and ZNF568 KRAB domain complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ANP", "MG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OXM", "evidence_id": "EV-PDB-8OXM-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.3 }, "provenance": { "deposit_id": "8OXM", "doi": "10.1126/sciadv.adi8291", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OXM" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ATM(Q2971A) activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ANP", "MG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains E,F)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8OXO", "evidence_id": "EV-PDB-8OXO-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "8OXO", "doi": "10.1126/sciadv.adi8291", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8OXO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "ATM(Q2971A) dimeric C-terminal region activated by oxidative stress in complex with Mg AMP-PNP and p53 peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8QWK", "evidence_id": "EV-PDB-8QWK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.69 }, "provenance": { "deposit_id": "8QWK", "doi": "10.1038/s41419-024-06739-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8QWK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of p53 cancer mutant Y126C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "MLI", "ZN" ], 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null, "environment": "in_vitro", "ions": [], "ligands": [ "A1ARO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9BR3", "evidence_id": "EV-PDB-9BR3-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "9BR3", "doi": "10.1158/2159-8290.CD-24-1421", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9BR3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 Y220C mutant in 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"deposit", "technique": "xray", "title": "Crystal structure of p53 Y220C mutant in complex with PC-9859" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Immunoglobulin G-binding protein G/Cellular tumor antigen p53 fusion protein (chains B)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9CHT", "evidence_id": "EV-PDB-9CHT-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.54 }, "provenance": { "deposit_id": "9CHT", "doi": "10.1016/j.str.2024.12.013", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9CHT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Human E3 ligase E6AP in complex with HPV16-E6 and p53" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NI", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Peptide from Cellular tumor antigen p53 (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9EIQ", "evidence_id": "EV-PDB-9EIQ-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.21 }, "provenance": { "deposit_id": "9EIQ", "doi": "10.1016/j.immuni.2026.08.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9EIQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of HLA-B*07:02 with the 9-mer TP53 peptide RPILTIITL" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO", "NI", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Peptide from Cellular tumor antigen p53 (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9EJD", "evidence_id": "EV-PDB-9EJD-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.15 }, "provenance": { "deposit_id": "9EJD", "doi": "10.1016/j.immuni.2026.08.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9EJD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of HLA-B*07:02 with the 9-mer TP53 mutant peptide SPILTIITL" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACY", "CL", "EDO", "NI", "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Mutant peptide from Cellular tumor antigen p53 (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9EK4", "evidence_id": "EV-PDB-9EK4-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.05 }, "provenance": { "deposit_id": "9EK4", "doi": "10.1016/j.immuni.2026.08.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9EK4" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of HLA-B*07:02 with the 9-mer TP53 mutant peptide MPILTIITL" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9FZB", "evidence_id": "EV-PDB-9FZB-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.44 }, "provenance": { "deposit_id": "9FZB", "doi": "10.1038/s41594-024-01456-7", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9FZB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human p53 DNA-binding domain bound to DARPin C10-H82R" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1IIO", "EDO", "EPE", "GOL", "PEG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": 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temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9G6T", "evidence_id": "EV-PDB-9G6T-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.56 }, "provenance": { "deposit_id": "9G6T", "doi": "10.2147/DDDT.S513792", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9G6T" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53-Y220C Core Domain Covalently Bound to 5-Chloro-6-methylpyrazine-2-carbonitrile Soaked at 5 mM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1II1", "EDO", "EPE", "GOL", "PEG", "PGE", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9G6U", "evidence_id": "EV-PDB-9G6U-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.64 }, "provenance": { "deposit_id": "9G6U", "doi": "10.2147/DDDT.S513792", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9G6U" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53-Y220C Core Domain Covalently Bound to 3,5-Dichloro-6-Ethylpyrazine-2-carbonitirle Soaked at 5 mM" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9C5S", "evidence_id": "EV-PDB-9C5S-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.01 }, "provenance": { "deposit_id": "9C5S", "doi": "10.21203/rs.3.rs-4644285/v1", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9C5S" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Disulfide-linked, antiparallel p53-derived peptide dimer (CV1)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8UQR", "evidence_id": "EV-PDB-8UQR-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.22 }, "provenance": { "deposit_id": "8UQR", "doi": "10.3390/ijms242316620", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": 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"Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPM", "evidence_id": "EV-PDB-9SPM-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.71 }, "provenance": { "deposit_id": "9SPM", "doi": "10.1073/pnas.2531747123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPM" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant V143A in complex with DARPin C10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPN", "evidence_id": "EV-PDB-9SPN-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.93 }, "provenance": { "deposit_id": "9SPN", "doi": "10.1073/pnas.2531747123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPN" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant V157F in complex with DARPin C10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPO", "evidence_id": "EV-PDB-9SPO-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.48 }, "provenance": { "deposit_id": "9SPO", "doi": "10.1073/pnas.2531747123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y220C in complex with DARPin C10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPP", "evidence_id": "EV-PDB-9SPP-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.47 }, "provenance": { "deposit_id": "9SPP", "doi": "10.1073/pnas.2531747123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPP" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant Y234C in complex with DARPin C10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPQ", "evidence_id": "EV-PDB-9SPQ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "9SPQ", "doi": "10.1073/pnas.2531747123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant V272M in complex with DARPin C10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPR", "evidence_id": "EV-PDB-9SPR-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.66 }, "provenance": { "deposit_id": "9SPR", "doi": "10.1073/pnas.2531747123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant R282W in complex with DARPin C10" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SPS", "evidence_id": "EV-PDB-9SPS-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.42 }, "provenance": { "deposit_id": "9SPS", "doi": "10.1073/pnas.2531747123", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SPS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53 cancer mutant E285K in complex with DARPin C10-H82R" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1JQW", "EDO", "EPE", "GOL", "PEG", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SUK", "evidence_id": "EV-PDB-9SUK-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.56 }, "provenance": { "deposit_id": "9SUK", "doi": "10.1002/pro.70629", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SUK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53-R282W Core Domain Covalently Bound to a Vinyl-Sulfone Fragment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1JQW", "EDO", "EPE", "PEG", "PGE", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9SZZ", "evidence_id": "EV-PDB-9SZZ-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "9SZZ", "doi": "10.1002/pro.70629", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9SZZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "p53-Y220C Core Domain Covalently Bound to a Vinyl-Sulfone Fragment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains C)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9U4D", "evidence_id": "EV-PDB-9U4D-2", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.39 }, "provenance": { "deposit_id": "9U4D", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9U4D" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Structure of UBE3A-E6-p53 complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Peptide from Cellular tumor antigen p53 (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9YZH", "evidence_id": "EV-PDB-9YZH-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.25 }, "provenance": { "deposit_id": "9YZH", "doi": "10.1016/j.immuni.2026.08.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9YZH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of HLA*02:01 with the 11-mer TP53 mutant peptide GLAPPQHLFRV" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1JMR", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9S9O", "evidence_id": "EV-PDB-9S9O-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.49 }, "provenance": { "deposit_id": "9S9O", "doi": "10.1038/s41419-026-08492-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9S9O" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1JMP", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9S9N", "evidence_id": "EV-PDB-9S9N-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.72 }, "provenance": { "deposit_id": "9S9N", "doi": "10.1038/s41419-026-08492-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9S9N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt analog 8" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1JMO", "EDO", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9S9M", "evidence_id": "EV-PDB-9S9M-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.83 }, "provenance": { "deposit_id": "9S9M", "doi": "10.1038/s41419-026-08492-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9S9M" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt analog 7" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "A1JMS", "EDO", "GOL", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Cellular tumor antigen p53 (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9S9L", "evidence_id": "EV-PDB-9S9L-1", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.38 }, "provenance": { "deposit_id": "9S9L", "doi": "10.1038/s41419-026-08492-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9S9L" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of p53 cancer mutant Y220C in complex with rezatapopt precursor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains K,L,M,N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9R2P", "evidence_id": "EV-PDB-9R2P-7", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.18 }, "provenance": { "deposit_id": "9R2P", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9R2P" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "p53 bound to nucleosome at position SHL+5.9 (crosslinked sample)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains K,L,M,N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9R2M", "evidence_id": "EV-PDB-9R2M-7", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.5 }, "provenance": { "deposit_id": "9R2M", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9R2M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "p53 bound to nucleosome at position SHL+5.9 (non-crosslinked sample, composite map)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Cellular tumor antigen p53 (chains K,L,M,N)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9R04", "evidence_id": "EV-PDB-9R04-7", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.2 }, "provenance": { "deposit_id": "9R04", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9R04" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "p53 bound to the nucleosome at position SHL-5.7 (crosslinked sample)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Peptide from Cellular tumor antigen p53 (chains C,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9OBF", "evidence_id": "EV-PDB-9OBF-3", "mappings": [], "molecule_id": "P04637", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.25 }, "provenance": { "deposit_id": "9OBF", "doi": "10.1016/j.immuni.2026.08.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9OBF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of HLA*02:01 with the 11-mer TP53 peptide GLAPPQHLIRV" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.8, "salt_mM": null, "temperature_c": 31.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=11578", "evidence_id": "EV-BMRB-11578", "mappings": [], "molecule_id": "P04637", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr11578", "doi": "10.13018/BMR11578", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=11578" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.3, "salt_mM": null, "temperature_c": 34.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=15944", "evidence_id": "EV-BMRB-15944", "mappings": [], "molecule_id": "P04637", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr15944", "doi": "10.13018/BMR15944", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=15944" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structural Basis for the Regulation of p53 Function by p300" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=17073", "evidence_id": "EV-BMRB-17073", "mappings": [], "molecule_id": "P04637", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr17073", "doi": "10.13018/BMR17073", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=17073" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure of CBP nuclear 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"uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A0024", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A0024/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 1AIE" } ], "models": [], "molecule": { "components": [], "domains": [], "gene": "TP53", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P04637" }, "ligands": [ "Zn(2+)" ], "modifications": [ { "kind": "ptm", "name": "Phosphoserine; by HIPK4", "position": 9, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM", "position": 15, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine; by CK1, VRK1 and VRK2", "position": 18, "source": 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"ptm", "name": "N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate", "position": 373, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 373, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 381, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6,N6-dimethyllysine; alternate", "position": 382, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine; alternate", "position": 382, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-methyllysine; by KMT5A; alternate", "position": 382, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CK2, CDK2 and NUAK1", "position": 392, "source": "UniProtKB" } ], "molecule_id": "P04637", "molecule_type": "protein", "name": "Cellular tumor antigen p53", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P04637", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04637/entry" }, "sequence": "MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD", "sequence_length": 393 }, "molecule_id": "P04637", "states": [], "transitions": [] }