{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "saxs_sans", "force_spectroscopy" ], "unmapped_evidence": 127 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PPX", "evidence_id": "EV-PDB-3PPX-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.91 }, "provenance": { "deposit_id": "3PPX", "doi": "10.1182/blood-2010-11-321596", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PPX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the N1602A mutant of an engineered VWF A2 domain (N1493C and C1670S)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains A,B,D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7PMV", "evidence_id": "EV-PDB-7PMV-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "7PMV", "doi": "10.1073/pnas.2116790119", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7PMV" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF Tubules of D1D2D'D3 domains" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8D3D", "evidence_id": "EV-PDB-8D3D-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "8D3D", "doi": "10.1182/blood.2022016467", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8D3D" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF tubule derived from dimeric D1-A1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8D3C", "evidence_id": "EV-PDB-8D3C-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "8D3C", "doi": "10.1182/blood.2022016467", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8D3C" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF tubule derived from monomeric D1-A1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains G,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7ZWH", "evidence_id": "EV-PDB-7ZWH-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7ZWH", "doi": "10.1182/blood.2022017153", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7ZWH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF Tubules of D1D2 and D'D3A1 domains" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains D,E)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7ZWH", "evidence_id": "EV-PDB-7ZWH-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "7ZWH", "doi": "10.1182/blood.2022017153", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7ZWH" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF Tubules of D1D2 and D'D3A1 domains" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains C,D,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WQT", "evidence_id": "EV-PDB-7WQT-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.3 }, "provenance": { "deposit_id": "7WQT", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WQT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (VWF tube)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains A,B,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WQT", "evidence_id": "EV-PDB-7WQT-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.3 }, "provenance": { "deposit_id": "7WQT", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WQT" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (VWF tube)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains C,D,F,H,J,L,N,P,R,T,V,X,Z,b)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPS", "evidence_id": "EV-PDB-7WPS-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.32 }, "provenance": { "deposit_id": "7WPS", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (7 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains A,B,E,G,I,K,M,O,Q,S,U,W,Y,a)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPS", "evidence_id": "EV-PDB-7WPS-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.32 }, "provenance": { "deposit_id": "7WPS", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPS" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (7 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains C,D,S,T,U,V,W,X,Y,Z,a,b,c,d,e,f)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPR", "evidence_id": "EV-PDB-7WPR-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.39 }, "provenance": { "deposit_id": "7WPR", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF D'D3 dimer complexed with D1D2 at 4.39 angstron resolution(VWF tube)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains A,B,E,F,G,H,I,J,K,L,M,N,O,P,Q,R)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPR", "evidence_id": "EV-PDB-7WPR-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.39 }, "provenance": { "deposit_id": "7WPR", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPR" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF D'D3 dimer complexed with D1D2 at 4.39 angstron resolution(VWF tube)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains C,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPQ", "evidence_id": "EV-PDB-7WPQ-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.267 }, "provenance": { "deposit_id": "7WPQ", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 3.27 angstron resolution (2 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains A,B,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPQ", "evidence_id": "EV-PDB-7WPQ-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.267 }, "provenance": { "deposit_id": "7WPQ", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPQ" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 3.27 angstron resolution (2 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPP", "evidence_id": "EV-PDB-7WPP-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "7WPP", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 2.85 angstron resolution (1 unit)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WPP", "evidence_id": "EV-PDB-7WPP-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "7WPP", "doi": "10.1182/blood.2021014729", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WPP" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 2.85 angstron resolution (1 unit)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains C,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WN6", "evidence_id": "EV-PDB-7WN6-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "7WN6", "doi": "10.1038/s41421-022-00378-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WN6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer (R1136M/E1143M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains A,B,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WN6", "evidence_id": "EV-PDB-7WN6-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "7WN6", "doi": "10.1038/s41421-022-00378-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WN6" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer (R1136M/E1143M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WN4", "evidence_id": "EV-PDB-7WN4-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7WN4", "doi": "10.1038/s41421-022-00378-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WN4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer (wild type) complexed with D1D2 at 3.4 angstron resolution (1 unit)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WN4", "evidence_id": "EV-PDB-7WN4-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.4 }, "provenance": { "deposit_id": "7WN4", "doi": "10.1038/s41421-022-00378-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WN4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer (wild type) complexed with D1D2 at 3.4 angstron resolution (1 unit)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains C,D,F,H)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WN3", "evidence_id": "EV-PDB-7WN3-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "7WN3", "doi": "10.1038/s41421-022-00378-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WN3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand antigen 2 (chains A,B,E,G)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WN3", "evidence_id": "EV-PDB-7WN3-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.29 }, "provenance": { "deposit_id": "7WN3", "doi": "10.1038/s41421-022-00378-2", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WN3" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor (chains B,D)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7PNF", "evidence_id": "EV-PDB-7PNF-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.35 }, "provenance": { "deposit_id": "7PNF", "doi": "10.1073/pnas.2116790119", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7PNF" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "VWF Tubules of D1D2D'D3 domains" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7P4N", "evidence_id": "EV-PDB-7P4N-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "7P4N", "doi": "10.1016/j.jsb.2022.107923", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7P4N" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR solution structure of the C6 domain of von Willebrand Factor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "CU", "NAG", "ZN", "branched: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "von Willebrand factor-XTEN-Fc (chains V)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7KWO", "evidence_id": "EV-PDB-7KWO-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "7KWO", "doi": "10.1182/blood.2020009197", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7KWO" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "rFVIIIFc-VWF-XTEN (BIVV001)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7F49", "evidence_id": "EV-PDB-7F49-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.09 }, "provenance": { "deposit_id": "7F49", "doi": "10.1111/jth.14755", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7F49" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "von Willebrand factor (VWF) A1 domain with BT-100 aptamer RNA" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7EOW", "evidence_id": "EV-PDB-7EOW-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.6 }, "provenance": { "deposit_id": "7EOW", "doi": "10.1016/j.bbrc.2021.06.030", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7EOW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "High-resolution structure of vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "NAG", "PEG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6N29", "evidence_id": "EV-PDB-6N29-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "6N29", "doi": "10.1182/blood-2018-10-876300", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6N29" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of monomeric von Willebrand Factor D`D3 assembly" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6FWN", "evidence_id": "EV-PDB-6FWN-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "6FWN", "doi": "10.1182/blood-2018-04-843615", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6FWN" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "EDO" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 10.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/5BV8", "evidence_id": "EV-PDB-5BV8-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.59 }, "provenance": { "deposit_id": "5BV8", "doi": "10.1074/jbc.M115.703850", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/5BV8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "G1324S mutation in von Willebrand Factor A1 domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "SO4", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4NT5", "evidence_id": "EV-PDB-4NT5-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.281 }, "provenance": { "deposit_id": "4NT5", "doi": "10.1182/blood-2013-11-523639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4NT5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of human von Willebrand factor CTCK domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains B,D,F,H,J,L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4DMU", "evidence_id": "EV-PDB-4DMU-2", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "4DMU", "doi": "10.1073/pnas.1112388109", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4DMU" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the von Willebrand factor A3 domain in complex with a collagen III derived triple-helical peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MES", "PEG", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A,C,E,G)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4C2B", "evidence_id": "EV-PDB-4C2B-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.8 }, "provenance": { "deposit_id": "4C2B", "doi": "10.1074/JBC.M113.511220", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4C2B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "CA", "CAC", "PEG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4C2A", "evidence_id": "EV-PDB-4C2A-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.081 }, "provenance": { "deposit_id": "4C2A", "doi": "10.1074/JBC.M113.511220", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4C2A" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "CA", "PEG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -180.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4C29", "evidence_id": "EV-PDB-4C29-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.202 }, "provenance": { "deposit_id": "4C29", "doi": "10.1074/JBC.M113.511220", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4C29" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "GOL", "NAG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3ZQK", "evidence_id": "EV-PDB-3ZQK-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.7 }, "provenance": { "deposit_id": "3ZQK", "doi": "10.1038/NCOMMS1385", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3ZQK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Von Willebrand Factor A2 domain with calcium" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PPY", "evidence_id": "EV-PDB-3PPY-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "3PPY", "doi": "10.1182/blood-2010-11-321596", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PPY" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PPW", "evidence_id": "EV-PDB-3PPW-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "3PPW", "doi": "10.1182/blood-2010-11-321596", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PPW" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the D1596A mutant of an engineered VWF A2 domain (N1493C and C1670S)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CA", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3PPV", "evidence_id": "EV-PDB-3PPV-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "3PPV", "doi": "10.1182/blood-2010-11-321596", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3PPV" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of an engineered VWF A2 domain (N1493C and C1670S)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand Factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HXQ", "evidence_id": "EV-PDB-3HXQ-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.694 }, "provenance": { "deposit_id": "3HXQ", "doi": "10.1016/j.str.2009.09.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HXQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.1, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HXO", "evidence_id": "EV-PDB-3HXO-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "3HXO", "doi": "10.1016/j.str.2009.09.011", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HXO" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NAG", "SO4", "branched: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand factor (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3GXB", "evidence_id": "EV-PDB-3GXB-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "3GXB", "doi": "10.1073/pnas.0903679106", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3GXB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of VWF A2 domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MHQ", "evidence_id": "EV-PDB-2MHQ-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MHQ", "doi": "10.1182/blood-2013-07-517086", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MHQ" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the major factor VIII binding region on von Willebrand factor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2MHP", "evidence_id": "EV-PDB-2MHP-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2MHP", "doi": "10.1182/blood-2013-07-517086", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2MHP" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Solution structure of the major factor VIII binding region on von Willebrand factor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACY", "GOL", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2ADF", "evidence_id": "EV-PDB-2ADF-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.9 }, "provenance": { "deposit_id": "2ADF", "doi": "10.1074/jbc.M508191200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2ADF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.8, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand Factor (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1UEX", "evidence_id": "EV-PDB-1UEX-3", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.85 }, "provenance": { "deposit_id": "1UEX", "doi": "10.1074/jbc.M305566200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1UEX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of von Willebrand Factor A1 domain complexed with snake venom bitiscetin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1U0N", "evidence_id": "EV-PDB-1U0N-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.95 }, "provenance": { "deposit_id": "1U0N", "doi": "10.1038/nsmb892", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1U0N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The ternary von Willebrand Factor A1-glycoprotein Ibalpha-botrocetin complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II] (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1SQ0", "evidence_id": "EV-PDB-1SQ0-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1SQ0", "doi": "10.1074/jbc.M401659200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1SQ0" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -183.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1OAK", "evidence_id": "EV-PDB-1OAK-3", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1OAK", "doi": "10.1038/nsb0398-189", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1OAK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN IN COMPLEX WITH THE FUNCTION BLOCKING NMC-4 FAB" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "von Willebrand Factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1M10", "evidence_id": "EV-PDB-1M10-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "1M10", "doi": "10.1126/science.107355", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1M10" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -162.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1IJK", "evidence_id": "EV-PDB-1IJK-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "1IJK", "doi": "10.1016/S0969-2126(02)00787-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1IJK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The von Willebrand Factor mutant (I546V) A1 domain-botrocetin Complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.6, "salt_mM": null, "temperature_c": -177.15 }, "construct": { "description": "von Willebrand factor (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1IJB", "evidence_id": "EV-PDB-1IJB-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "1IJB", "doi": "10.1016/S0969-2126(02)00787-6", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1IJB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The von Willebrand Factor mutant (I546V) A1 domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -183.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1FNS", "evidence_id": "EV-PDB-1FNS-3", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "1FNS", "doi": "10.1038/79639", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1FNS" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CAC", "NAG", "branched: alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1FE8", "evidence_id": "EV-PDB-1FE8-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.03 }, "provenance": { "deposit_id": "1FE8", "doi": "10.1074/jbc.M006548200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1FE8" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "A1 DOMAIN OF VON WILLEBRAND FACTOR (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1AUQ", "evidence_id": "EV-PDB-1AUQ-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "1AUQ", "doi": "10.1074/jbc.273.17.10396", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1AUQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "A1 DOMAIN OF VON WILLEBRAND FACTOR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1ATZ", "evidence_id": "EV-PDB-1ATZ-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "1ATZ", "doi": "10.1016/S0969-2126(97)00266-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1ATZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "HUMAN VON WILLEBRAND FACTOR A3 DOMAIN" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": 13.85 }, "construct": { "description": "VON WILLEBRAND FACTOR (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1AO3", "evidence_id": "EV-PDB-1AO3-1", "mappings": [], "molecule_id": "P04275", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1AO3", "doi": "10.1074/jbc.272.40.25162", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1AO3" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "A3 DOMAIN OF VON WILLEBRAND FACTOR" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34243", "evidence_id": "EV-BMRB-34243", "mappings": [], "molecule_id": "P04275", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34243", "doi": "10.13018/BMR34243", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34243" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 6.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=34648", "evidence_id": "EV-BMRB-34648", "mappings": [], "molecule_id": "P04275", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr34648", "doi": "10.13018/BMR34648", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=34648" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "NMR solution structure of the C6 domain of von Willebrand Factor" }, { "conditions": { "applied_force_pn": null, "buffer": "10 mM HEPES, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 14 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDKT8/", "evidence_id": "EV-SASBDB-SASDKT8", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.03, "unit": "nm", "value": 3.08 }, "provenance": { "deposit_id": "SASDKT8", "doi": "10.1016/j.jmb.2021.166954", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDKT8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution." }, { "conditions": { "applied_force_pn": null, "buffer": "10 mM HEPES, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 14.93 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDKU8/", "evidence_id": "EV-SASBDB-SASDKU8", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.024, "unit": "nm", "value": 3.04 }, "provenance": { "deposit_id": "SASDKU8", "doi": "10.1016/j.jmb.2021.166954", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDKU8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution." }, { "conditions": { "applied_force_pn": null, "buffer": "10 mM HEPES, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [ "partner: A disintegrin and metalloproteinase with thrombospondin motifs 13" ], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16.3 nm.", "ph": 7.4, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor with A disintegrin and metalloproteinase with thrombospondin motifs 13", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDKV8/", "evidence_id": "EV-SASBDB-SASDKV8", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.014, "unit": "nm", "value": 4.38 }, "provenance": { "deposit_id": "SASDKV8", "doi": "10.1016/j.jmb.2021.166954", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDKV8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution." }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris-HCl, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 6.61 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor C6 domain wild type", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLQ9/", "evidence_id": "EV-SASBDB-SASDLQ9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.006, "unit": "nm", "value": 1.749 }, "provenance": { "deposit_id": "SASDLQ9", "doi": "10.1016/j.jsb.2022.107923", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLQ9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM Tris-HCl, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 6.7 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor C6 domain G2705K mutant", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLR9/", "evidence_id": "EV-SASBDB-SASDLR9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.01, "unit": "nm", "value": 1.8 }, "provenance": { "deposit_id": "SASDLR9", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLR9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 15 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 25.0 }, "construct": { "description": "von Willebrand factor C6-CK wildtype", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLS9/", "evidence_id": "EV-SASBDB-SASDLS9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.023, "unit": "nm", "value": 3.27 }, "provenance": { "deposit_id": "SASDLS9", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLS9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16.5 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 25.0 }, "construct": { "description": "von Willebrand factor C6-CK G2705R", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLT9/", "evidence_id": "EV-SASBDB-SASDLT9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.012, "unit": "nm", "value": 3.453 }, "provenance": { "deposit_id": "SASDLT9", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLT9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES, 150 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 16 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 25.0 }, "construct": { "description": "von Willebrand factor C6-CK G2705K", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLU9/", "evidence_id": "EV-SASBDB-SASDLU9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.012, "unit": "nm", "value": 3.515 }, "provenance": { "deposit_id": "SASDLU9", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLU9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES, 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 34.8 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor D4N-CK wildtype", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLV9/", "evidence_id": "EV-SASBDB-SASDLV9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.019, "unit": "nm", "value": 7.808 }, "provenance": { "deposit_id": "SASDLV9", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLV9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES, 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 68.54 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor D4N-CK G2705R", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLW9/", "evidence_id": "EV-SASBDB-SASDLW9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.076, "unit": "nm", "value": 11.356 }, "provenance": { "deposit_id": "SASDLW9", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLW9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": "20 mM HEPES, 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 52 nm.", "ph": 7.5, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "von Willebrand factor D4N-CK G2705K", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDLX9/", "evidence_id": "EV-SASBDB-SASDLX9", "mappings": [], "molecule_id": "P04275", "observable": { "type": "radius_of_gyration", "uncertainty": 0.053, "unit": "nm", "value": 9.812 }, "provenance": { "deposit_id": "SASDLX9", "doi": null, "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDLX9/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "Structure and dynamics of the von Willebrand Factor C6 domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 1478-1493; evidence: X-ray crystallography-based structural model with missing residue coordinates used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/21750539", "evidence_id": "EV-DISPROT-DP02981r001", "mappings": [], "molecule_id": "P04275", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 16 }, "provenance": { "deposit_id": "DP02981r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP02981" }, "reader": null, "source_kind": "literature", "technique": "xray", "title": "DisProt DP02981: disorder, residues 1478-1493" } ], "models": [], "molecule": { "components": [], "domains": [ { "end": 201, "name": "VWFD 1", "start": 33 }, { "end": 348, "name": "TIL 1", "start": 295 }, { "end": 560, "name": "VWFD 2", "start": 386 }, { "end": 707, "name": "TIL 2", "start": 652 }, { "end": 827, "name": "TIL 3", "start": 776 }, { "end": 1032, "name": "VWFD 3", "start": 865 }, { "end": 1196, "name": "TIL 4", "start": 1146 }, { "end": 1453, "name": "VWFA 1; binding site for platelet glycoprotein Ib", "start": 1277 }, { "end": 1665, "name": "VWFA 2", "start": 1498 }, { "end": 1871, "name": "VWFA 3; main binding site for collagens type I and III", "start": 1691 }, { "end": 2124, "name": "VWFD 4", "start": 1948 }, { "end": 2328, "name": "VWFC 1", "start": 2255 }, { "end": 2495, "name": "VWFC 2", "start": 2429 }, { "end": 2645, "name": "VWFC 3", "start": 2580 }, { "end": 2812, "name": "CTCK", "start": 2724 } ], "gene": "VWF", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P04275" }, "ligands": [], "modifications": [], "molecule_id": "P04275", "molecule_type": "protein", "name": "von Willebrand factor", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P04275", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04275/entry" }, "sequence": "MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADNLRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVKIGCNTCVCQDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVDFGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVEDISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRITLLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTLSPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTMVTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCDRGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNKEQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFYAICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHCDGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHCERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVNSTVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMYSIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK", "sequence_length": 2813 }, "molecule_id": "P04275", "states": [], "transitions": [] }