{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "microed", "nmr_structure", "nmr_shifts", "saxs_sans", "force_spectroscopy", "af_prediction" ], "unmapped_evidence": 121 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "PRION PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1QM2", "evidence_id": "EV-PDB-1QM2-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1QM2", "doi": "10.1073/PNAS.97.1.145", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1QM2" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Human prion protein fragment 121-230" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4N9O", "evidence_id": "EV-PDB-4N9O-1", "mappings": [], "molecule_id": "P04156", 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"https://www.rcsb.org/structure/4KML", "evidence_id": "EV-PDB-4KML-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "4KML", "doi": "10.1021/ja407527p", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4KML" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains 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prion protein (chains A,C,E,G,I,K)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4E1I", "evidence_id": "EV-PDB-4E1I-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.03 }, "provenance": { "deposit_id": "4E1I", "doi": "10.1021/ja403001q", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4E1I" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment of human prion protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CIT", "FE" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains B,D,F,H,J,L)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4E1H", "evidence_id": "EV-PDB-4E1H-2", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "4E1H", "doi": "10.1021/ja403001q", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4E1H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment of human prion protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CIT", "FE" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 3.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,C,E,G,I,K)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4E1H", "evidence_id": "EV-PDB-4E1H-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "4E1H", "doi": "10.1021/ja403001q", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4E1H" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Fragment of human prion protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "NA" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4DGI", "evidence_id": "EV-PDB-4DGI-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "4DGI", "doi": "10.1107/S0907444912037328", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/4DGI" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of POM1 FAB fragment complexed with human PrPc Fragment 120-230" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "MPD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.4, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3NVF", "evidence_id": "EV-PDB-3NVF-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3NVF", "doi": "10.1021/bi101803k", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3NVF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "IIHFGS segment 138-143 from human prion" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACY" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3NHD", "evidence_id": "EV-PDB-3NHD-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.92 }, "provenance": { "deposit_id": "3NHD", "doi": "10.1074/jbc.C110.158303", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3NHD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "GYVLGS segment 127-132 from human prion with V129" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3NHC", "evidence_id": "EV-PDB-3NHC-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.57 }, "provenance": { "deposit_id": "3NHC", "doi": "10.1074/jbc.C110.158303", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3NHC" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "GYMLGS segment 127-132 from human prion with M129" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3MD5", "evidence_id": "EV-PDB-3MD5-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "3MD5", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3MD5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Prion peptide" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": 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"Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HJX", "evidence_id": "EV-PDB-3HJX-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "3HJX", "doi": "10.1038/emboj.2009.333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HJX" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human prion protein variant D178N with V129" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HJ5", "evidence_id": "EV-PDB-3HJ5-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.1 }, "provenance": { "deposit_id": "3HJ5", "doi": "10.1038/emboj.2009.333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HJ5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human prion protein variant V129 domain swapped dimer" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HES", "evidence_id": "EV-PDB-3HES-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.0 }, "provenance": { "deposit_id": "3HES", "doi": "10.1038/emboj.2009.333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HES" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human prion protein variant F198S with M129" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HER", "evidence_id": "EV-PDB-3HER-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.85 }, "provenance": { "deposit_id": "3HER", "doi": "10.1038/emboj.2009.333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HER" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human prion protein variant F198S with V129" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CD" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HEQ", "evidence_id": "EV-PDB-3HEQ-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3HEQ", "doi": "10.1038/emboj.2009.333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HEQ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human prion protein variant D178N with M129" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HAK", "evidence_id": "EV-PDB-3HAK-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "3HAK", "doi": "10.1038/emboj.2009.333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HAK" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human prion protein variant V129" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CD", "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 10.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3HAF", "evidence_id": "EV-PDB-3HAF-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.26 }, "provenance": { "deposit_id": "3HAF", "doi": "10.1038/emboj.2009.333", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3HAF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human prion protein variant V129 domain swapped dimer" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "MAJOR PRION PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2W9E", "evidence_id": "EV-PDB-2W9E-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "2W9E", "doi": "10.1073/PNAS.0809170106", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2W9E" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of ICSM 18 (anti-Prp therapeutic antibody) Fab fragment complexed with human Prp fragment 119-231" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "peptide from human prion (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2OL9", "evidence_id": "EV-PDB-2OL9-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 0.85 }, "provenance": { "deposit_id": "2OL9", "doi": "10.1038/nature05695", 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"evidence_id": "EV-PDB-2LFT-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LFT", "doi": "10.1042/BJ20111940", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LFT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Human prion protein with E219K protective polymorphism" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2LEJ", "evidence_id": "EV-PDB-2LEJ-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2LEJ", "doi": "10.1016/j.jmb.2011.07.067", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2LEJ" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "human prion protein mutant HuPrP(90-231, M129, V210I)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.6, "salt_mM": null, "temperature_c": 36.85 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR 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"labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2KUN", "evidence_id": "EV-PDB-2KUN-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2KUN", "doi": "10.1371/journal.pone.0011715", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2KUN" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Three dimensional structure of HuPrP(90-231 M129 Q212P)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": 25.85 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2K1D", "evidence_id": "EV-PDB-2K1D-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2K1D", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2K1D" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR Studies of a Pathogenic Mutant (D178N) of the Human Prion Protein" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "MAJOR PRION PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2IV6", "evidence_id": "EV-PDB-2IV6-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2IV6", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2IV6" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "hPrP-173-195-D178N solution structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "MAJOR PRION PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2IV5", "evidence_id": "EV-PDB-2IV5-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "2IV5", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2IV5" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "hPrP-173-195 solution structure" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.0, "salt_mM": 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"temperature_c": 19.85 }, "construct": { "description": "PRION PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1QM3", "evidence_id": "EV-PDB-1QM3-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1QM3", "doi": "10.1073/PNAS.97.1.145", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1QM3" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Human prion protein fragment 121-230" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "PRION PROTEIN (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1QM1", "evidence_id": "EV-PDB-1QM1-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1QM1", "doi": "10.1073/PNAS.97.1.145", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1QM1" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "Human prion protein fragment 90-230" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable 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ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Major prion protein (chains A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RL4", "evidence_id": "EV-PDB-7RL4-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.86 }, "provenance": { "deposit_id": "7RL4", "doi": "10.1038/s41594-022-00833-4", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RL4" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of human PrP23-144 amyloid fibrils" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RVC", "evidence_id": "EV-PDB-7RVC-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.002 }, "provenance": { "deposit_id": "7RVC", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RVC" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "Segment from the human prion protein 168-176 EYSNQNNFV" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RVE", "evidence_id": "EV-PDB-7RVE-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 0.85 }, "provenance": { "deposit_id": "7RVE", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RVE" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "Segment from the S170N mutant of the human prion protein 168-176 EYNNQNNFV" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A,B)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RVJ", "evidence_id": "EV-PDB-7RVJ-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.0 }, "provenance": { "deposit_id": "7RVJ", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RVJ" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "Segment from the human prion protein 169-175 YSNQNNF" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ACT", "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RVK", "evidence_id": "EV-PDB-7RVK-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.0 }, "provenance": { "deposit_id": "7RVK", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RVK" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "Segment from Y169G mutant of the human prion protein 169-175 GSNQNNF" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Major prion protein (chains A)", "labels": [] }, "data_format": "mmCIF", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7RVL", "evidence_id": "EV-PDB-7RVL-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.0 }, "provenance": { "deposit_id": "7RVL", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7RVL" }, "reader": null, "source_kind": "deposit", "technique": "microed", "title": "Segment from the Y169F mutant of the human prion protein 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"cryoem", "title": "Structure of Type I Prion filaments from Gerstmann-Straussler-Scheinker disease" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Major prion protein (chains A,B,C,D,E,F,G,H,I,J)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7UN5", "evidence_id": "EV-PDB-7UN5-1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.13 }, "provenance": { "deposit_id": "7UN5", "doi": "10.1007/s00401-022-02461-0", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": 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"https://bmrb.io/data_library/summary/index.php?bmrbId=15054" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "HPRP180-195 STRUCTURE" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 5.0, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=16505", "evidence_id": "EV-BMRB-16505", "mappings": [], "molecule_id": "P04156", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr16505", "doi": "10.13018/BMR16505", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=16505" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "NMR structure of the octarepeat region of prion protein bound to pentosan polysulfate" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": 5.5, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "BMRB data: 13C chemical shifts, 15N chemical shifts, 1H chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=16743", "evidence_id": "EV-BMRB-16743", "mappings": [], "molecule_id": "P04156", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr16743", "doi": "10.13018/BMR16743", "licence": "CC0 1.0 (verify)", "retrieved": 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"environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. 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Dmax 10.21 nm.", "ph": 7.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Major prion protein", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDNB8/", "evidence_id": "EV-SASBDB-SASDNB8", "mappings": [], "molecule_id": "P04156", "observable": { "type": "radius_of_gyration", "uncertainty": 0.02, "unit": "nm", "value": 2.83 }, "provenance": { "deposit_id": "SASDNB8", "doi": "10.1016/j.isci.2023.107480", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDNB8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "A tetracationic porphyrin with dual anti-prion activity." }, { "conditions": { "applied_force_pn": null, "buffer": "10 mM HEPES 100 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 11.25 nm.", "ph": 7.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Major prion protein", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDNC8/", "evidence_id": "EV-SASBDB-SASDNC8", "mappings": [], "molecule_id": "P04156", "observable": { "type": "radius_of_gyration", "uncertainty": 0.068, "unit": "nm", "value": 3.1 }, "provenance": { "deposit_id": "SASDNC8", "doi": "10.1016/j.isci.2023.107480", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDNC8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "A tetracationic porphyrin with dual anti-prion activity." }, { "conditions": { "applied_force_pn": null, "buffer": "10 mM HEPES 100 mM NaCl", "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Other molecules in the sample are listed as partners; Rg is of the whole sample. Dmax 10.25 nm.", "ph": 7.0, "salt_mM": null, "temperature_c": 20.0 }, "construct": { "description": "Major prion protein", "labels": [] }, "data_format": "scattering curve", "data_level": "processed", "data_link": "https://www.sasbdb.org/data/SASDND8/", "evidence_id": "EV-SASBDB-SASDND8", "mappings": [], "molecule_id": "P04156", "observable": { "type": "radius_of_gyration", "uncertainty": 0.022, "unit": "nm", "value": 2.84 }, "provenance": { "deposit_id": "SASDND8", "doi": "10.1016/j.isci.2023.107480", "licence": "CC BY 4.0 (verify)", "retrieved": "2026-10-19", "source": "SASBDB", "url": "https://www.sasbdb.org/data/SASDND8/" }, "reader": null, "source_kind": "deposit", "technique": "saxs_sans", "title": "A tetracationic porphyrin with dual anti-prion activity." }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 23-124; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/10618385", "evidence_id": "EV-DISPROT-DP00466r003", "mappings": [], "molecule_id": "P04156", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 102 }, "provenance": { "deposit_id": "DP00466r003", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP00466" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP00466: disorder, residues 23-124" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 23-124; evidence: nuclear magnetic resonance evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/30401430", "evidence_id": "EV-DISPROT-DP00466r006", "mappings": [], "molecule_id": "P04156", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 102 }, "provenance": { "deposit_id": "DP00466r006", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP00466" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP00466: disorder to order, residues 23-124" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-253", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/P04156", "evidence_id": "EV-AFDB-AF-P04156-F1", "mappings": [], "molecule_id": "P04156", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 64.19 }, "provenance": { "deposit_id": "AF-P04156-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/P04156" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-P04156-F1" } ], "models": [], "molecule": { "components": [], "domains": [], "gene": "PRNP", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P04156" }, "ligands": [ "Cu(2+)" ], "modifications": [], "molecule_id": "P04156", "molecule_type": "protein", "name": "Major prion protein", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P04156", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04156/entry" }, "sequence": "MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG", "sequence_length": 253 }, "molecule_id": "P04156", "states": [], "transitions": [] }