{ "conflicts": [], "coverage": { "cells": {}, "data_levels": {}, "single_method_states": [], "states": [], "techniques": [ "xray", "cryoem", "nmr_structure", "nmr_shifts", "force_spectroscopy", "af_prediction", "md" ], "unmapped_evidence": 51 }, "curation": { "as_of": "", "curator": "none", "file": "", "status": "uncurated" }, "evidence": [ { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.0, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Lamin A/C (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1IFR", "evidence_id": "EV-PDB-1IFR-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.4 }, "provenance": { "deposit_id": "1IFR", "doi": "10.1074/jbc.C200038200", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1IFR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Lamin A/C Globular Domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ZN" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "PRELAMIN-A/C (chains F,G,H,I)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2YPT", "evidence_id": "EV-PDB-2YPT-2", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.8 }, "provenance": { "deposit_id": "2YPT", "doi": "10.1126/SCIENCE.1231513", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2YPT" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Lamin-A/C (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3GEF", "evidence_id": "EV-PDB-3GEF-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.5 }, "provenance": { "deposit_id": "3GEF", "doi": "10.1107/S1744309109020302", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3GEF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of the R482W mutant of lamin A/C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 5.5, "salt_mM": null, "temperature_c": -100.15 }, "construct": { "description": "Prelamin-A/C (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3V4Q", "evidence_id": "EV-PDB-3V4Q-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.06 }, "provenance": { "deposit_id": "3V4Q", "doi": "10.1016/j.bbrc.2011.12.136", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3V4Q" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of R335W mutant of human Lamin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -100.15 }, "construct": { "description": "Prelamin-A/C (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3V5B", "evidence_id": "EV-PDB-3V5B-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.0 }, "provenance": { "deposit_id": "3V5B", "doi": "10.1016/j.bbrc.2011.12.136", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3V5B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of Coil 2b of human lamin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "EDO", "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Prelamin-A/C (chains B,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6GHD", "evidence_id": "EV-PDB-6GHD-3", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "6GHD", "doi": "10.1093/nar/gky736", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6GHD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Lamin A/C (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6JLB", "evidence_id": "EV-PDB-6JLB-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.205 }, "provenance": { "deposit_id": "6JLB", "doi": "10.1038/s41467-019-11684-x", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6JLB" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of lamin A/C fragment and assembly mechanisms of intermediate filaments" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.9, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Prelamin-A/C,Microtubule-associated protein RP/EB family member 1 (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YF5", "evidence_id": "EV-PDB-6YF5-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.83 }, "provenance": { "deposit_id": "6YF5", "doi": "10.3390/cells9071633", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YF5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Lamin A 17-70 coil1A dimer stabilized by C-terminal capping" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL", "NI", "TRS" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.2, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Capsid assembly scaffolding protein,Prelamin-A/C (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YJD", "evidence_id": "EV-PDB-6YJD-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.9 }, "provenance": { "deposit_id": "6YJD", "doi": "10.3390/cells9071633", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YJD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Lamin A coil2 dimer stabilized by N-terminal capping" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Prelamin-A/C,Microtubule-associated protein RP/EB family member 1 (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YSH", "evidence_id": "EV-PDB-6YSH-2", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "6YSH", "doi": "10.3390/cells9071633", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YSH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Lamin A 1-70 coil1A dimer stabilized by C-terminal capping" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Prelamin-A/C,Microtubule-associated protein RP/EB family member 1 (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6YSH", "evidence_id": "EV-PDB-6YSH-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.83 }, "provenance": { "deposit_id": "6YSH", "doi": "10.3390/cells9071633", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6YSH" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Lamin A 1-70 coil1A dimer stabilized by C-terminal capping" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "LYS-ALA-GLY-GLN-VAL-VAL-THR-ILE-TRP (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7WZZ", "evidence_id": "EV-PDB-7WZZ-3", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.305 }, "provenance": { "deposit_id": "7WZZ", "doi": "10.1038/s41598-023-36293-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7WZZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of peptide KAGQVVTIW in complex with HLA-B5801" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.9, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "LYS-ALA-GLY-GLN-VAL-VAL-THR-ILE (chains C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7X1B", "evidence_id": "EV-PDB-7X1B-3", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.399 }, "provenance": { "deposit_id": "7X1B", "doi": "10.1038/s41598-023-36293-z", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7X1B" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of peptide KAGQVVTI in complex with HLA-B5801" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Lamin-A/C (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7X5D", "evidence_id": "EV-PDB-7X5D-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.82 }, "provenance": { "deposit_id": "7X5D", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7X5D" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of the K316C mutant of Human Lamin A/C Coil 2 (residues 244-340)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SEC" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Lamin-A/C (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YVD", "evidence_id": "EV-PDB-7YVD-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.1 }, "provenance": { "deposit_id": "7YVD", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YVD" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "The crystal structure of the progerin C-terminal peptide and the Ig-like domain of lamin A/C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Lamin-A/C (chains M)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9J8M", "evidence_id": "EV-PDB-9J8M-8", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.82 }, "provenance": { "deposit_id": "9J8M", "doi": "10.1038/s41467-025-56823-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9J8M" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (High mobility complex)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Lamin-A/C (chains M,P,m,p)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9J8N", "evidence_id": "EV-PDB-9J8N-8", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 7.14 }, "provenance": { "deposit_id": "9J8N", "doi": "10.1038/s41467-025-56823-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9J8N" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (Low mobility complex)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "Lamin-A/C (chains M,m)", "labels": [] }, "data_format": "mmCIF + EMDB map", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9J8O", "evidence_id": "EV-PDB-9J8O-8", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 4.05 }, "provenance": { "deposit_id": "9J8O", "doi": "10.1038/s41467-025-56823-9", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9J8O" }, "reader": null, "source_kind": "deposit", "technique": "cryoem", "title": "Cryo-EM structure of BAF-Lamin A/C IgF-H1-nucleosome complex" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -193.15 }, "construct": { "description": "Lamin-A/C (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/9UL6", "evidence_id": "EV-PDB-9UL6-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.5 }, "provenance": { "deposit_id": "9UL6", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/9UL6" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of Lamin A/C Ig-like domain mutant - R435C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Prelamin-A/C (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/8I33", "evidence_id": "EV-PDB-8I33-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.62 }, "provenance": { "deposit_id": "8I33", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/8I33" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Coil 1a of lamin A (residue 25-65)" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "CL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 9.0, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Lamin-A/C (chains E,F)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7Z21", "evidence_id": "EV-PDB-7Z21-2", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.629 }, "provenance": { "deposit_id": "7Z21", "doi": "10.1093/nar/gkac726", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7Z21" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "BAF A12T bound to the lamin A/C Ig-fold domain" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Lamin-A/C (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7D9N", "evidence_id": "EV-PDB-7D9N-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "7D9N", "doi": "10.1038/s42003-022-03212-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7D9N" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of a non-canonic progeria mutation S143F at lamin A/C and its structural implication to the premature aging" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 24.85 }, "construct": { "description": "Prelamin-A/C (chains A,B,C)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7CRG", "evidence_id": "EV-PDB-7CRG-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 1.8 }, "provenance": { "deposit_id": "7CRG", "doi": "10.1016/j.bbrc.2021.02.102", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7CRG" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Beta-strand-mediated dimeric formation of the extended Ig-like domains of human lamin A/C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "GOL" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Prelamin-A/C (chains A,B,C,D)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6SNZ", "evidence_id": "EV-PDB-6SNZ-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.6 }, "provenance": { "deposit_id": "6SNZ", "doi": "10.1016/j.jsb.2019.10.006", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6SNZ" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal structure of lamin A coil1b tetramer" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "SO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": 19.85 }, "construct": { "description": "Prelamin-A/C (chains B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/6RPR", "evidence_id": "EV-PDB-6RPR-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.26 }, "provenance": { "deposit_id": "6RPR", "doi": "10.3390/cells8060570", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/6RPR" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "LEM domain of Emerin mutant T43I in complex with BAF dimer and the Igfold of the lamin A/C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 4.6, "salt_mM": null, "temperature_c": -100.15 }, "construct": { "description": "Prelamin-A/C (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/3V4W", "evidence_id": "EV-PDB-3V4W-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.7 }, "provenance": { "deposit_id": "3V4W", "doi": "10.1016/j.bbrc.2011.12.136", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/3V4W" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Structure of E347K mutant of Lamin" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 8.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "LAMIN-A/C (chains A,B)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/2XV5", "evidence_id": "EV-PDB-2XV5-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.4 }, "provenance": { "deposit_id": "2XV5", "doi": "10.1016/J.JMB.2011.02.037", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/2XV5" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human lamin A coil 2B fragment" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 7.5, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "Lamin A/C (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1X8Y", "evidence_id": "EV-PDB-1X8Y-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.2 }, "provenance": { "deposit_id": "1X8Y", "doi": "10.1016/j.jmb.2004.08.093", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1X8Y" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Human lamin coil 2B" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": 6.3, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "Lamin A/C (chains A)", "labels": [] }, "data_format": "mmCIF + NMR restraints", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/1IVT", "evidence_id": "EV-PDB-1IVT-1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "structure", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "1IVT", "doi": "10.1016/S0969-2126(02)00777-3", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/1IVT" }, "reader": null, "source_kind": "deposit", "technique": "nmr_structure", "title": "NMR structures of the C-terminal globular domain of human lamin A/C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "From the first sample condition list of the entry.", "ph": null, "salt_mM": null, "temperature_c": 29.85 }, "construct": { "description": "BMRB data: 1H chemical shifts, 13C chemical shifts, 15N chemical shifts", "labels": [] }, "data_format": "NMR-STAR", "data_level": "processed", "data_link": "https://bmrb.io/data_library/summary/index.php?bmrbId=5224", "evidence_id": "EV-BMRB-5224", "mappings": [], "molecule_id": "P02545", "observable": { "type": "chemical_shift", "uncertainty": null, "unit": null, "value": null }, "provenance": { "deposit_id": "bmr5224", "doi": "10.13018/BMR5224", "licence": "CC0 1.0 (verify)", "retrieved": "2026-10-19", "source": "BMRB", "url": "https://bmrb.io/data_library/summary/index.php?bmrbId=5224" }, "reader": null, "source_kind": "deposit", "technique": "nmr_shifts", "title": "1H, 13C and 15N Chemical shifts assignments for the C-terminal domain (region 428-547) of human lamin A/C" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [], "notes": "DisProt annotations do not record sample conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "residues 567-664; evidence: nuclear magnetic resonance spectroscopy evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/29582385", "evidence_id": "EV-DISPROT-DP00716r002", "mappings": [], "molecule_id": "P02545", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 98 }, "provenance": { "deposit_id": "DP00716r002", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP00716" }, "reader": null, "source_kind": "literature", "technique": "nmr_shifts", "title": "DisProt DP00716: disorder, residues 567-664" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-664", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/P02545", "evidence_id": "EV-AFDB-AF-P02545-F1", "mappings": [], "molecule_id": "P02545", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 76.38 }, "provenance": { "deposit_id": "AF-P02545-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/P02545" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-P02545-F1" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Simulation; temperature is the thermostat setting.", "ph": null, "salt_mM": null, "temperature_c": 26.85 }, "construct": { "description": "start 1IVT; Amber Parm99", "labels": [] }, "data_format": "trajectory", "data_level": "processed", "data_link": "https://mmb.mddbr.eu/#/id/A00L3/overview", "evidence_id": "EV-MDDB-A00L3", "mappings": [], "molecule_id": "P02545", "observable": { "type": "trajectory", "uncertainty": null, "unit": "ns", "value": 10.0 }, "provenance": { "deposit_id": "A00L3", "doi": "10.1016/j.str.2010.07.013", "licence": "This trajectory dataset is released under a Creative Commons Attribution 4.0 International Public License", "retrieved": "2026-10-19", "source": "MDDB", "url": "https://mmb.mddbr.eu/#/id/A00L3/overview" }, "reader": null, "source_kind": "computed", "technique": "md", "title": "MoDEL 1IVT" } ], "models": [], "molecule": { "components": [], "domains": [ { "end": 387, "name": "IF rod", "start": 31 }, { "end": 545, "name": "LTD", "start": 428 } ], "gene": "LMNA", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "P02545" }, "ligands": [], "modifications": [ { "kind": "ptm", "name": "N-acetylmethionine", "position": 1, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 3, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 5, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 10, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 12, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 18, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 19, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; 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by CDK1", "position": 392, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by ATR", "position": 395, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 398, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 403, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 404, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 406, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 407, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 414, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 416, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 417, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 423, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 426, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 429, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 431, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 450, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 457, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 458, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 463, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 486, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 496, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 505, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 510, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 533, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 546, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine", "position": 548, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 568, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 571, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 612, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 613, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 616, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 619, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 628, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 632, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 636, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 652, "source": "UniProtKB" }, { "kind": "ptm", "name": "Cysteine methyl ester", "position": 661, "source": "UniProtKB" } ], "molecule_id": "P02545", "molecule_type": "protein", "name": "Prelamin-A/C", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "P02545", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P02545/entry" }, "sequence": "METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM", "sequence_length": 664 }, "molecule_id": "P02545", "states": [], "transitions": [] }