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"temperature_c": -173.15 }, "construct": { "description": "ATP-dependent RNA helicase DDX3X (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/7YMF", "evidence_id": "EV-PDB-7YMF-1", "mappings": [], "molecule_id": "O00571", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 2.3 }, "provenance": { "deposit_id": "7YMF", "doi": null, "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", "source": "RCSB PDB", "url": "https://www.rcsb.org/structure/7YMF" }, "reader": null, "source_kind": "deposit", "technique": "xray", "title": "Crystal Structure of DDX3X449_450ET>DP" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "08T", "MG" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", 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"deposit", "technique": "xray", "title": "Crystal structure of the active catalytic core of the human DEAD-box protein DDX3" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_vitro", "ions": [], "ligands": [ "ADP", "PO4" ], "notes": "Entry-level ligand list; oligosaccharides appear as branched entities. pH and temperature are null when not deposited in machine-readable fields.", "ph": null, "salt_mM": null, "temperature_c": -173.15 }, "construct": { "description": "ATP-dependent RNA helicase DDX3X (chains A)", "labels": [] }, "data_format": "mmCIF + structure factors", "data_level": "processed", "data_link": "https://www.rcsb.org/structure/4PXA", "evidence_id": "EV-PDB-4PXA-1", "mappings": [], "molecule_id": "O00571", "observable": { "type": "resolution", "uncertainty": null, "unit": "Å", "value": 3.2 }, "provenance": { "deposit_id": "4PXA", "doi": "10.1016/j.jmb.2015.02.015", "licence": "CC0 1.0 (wwPDB archive data)", "retrieved": "2026-10-19", 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evidence: far-UV circular dichroism evidence used in manual assertion", "labels": [] }, "data_format": null, "data_level": "reported", "data_link": "https://europepmc.org/article/MED/19913487", "evidence_id": "EV-DISPROT-DP02192r001", "mappings": [], "molecule_id": "O00571", "observable": { "type": "disorder_region", "uncertainty": null, "unit": "residues", "value": 167 }, "provenance": { "deposit_id": "DP02192r001", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "DisProt", "url": "https://disprot.org/DP02192" }, "reader": null, "source_kind": "literature", "technique": "cd", "title": "DisProt DP02192: disorder, residues 1-167" }, { "conditions": { "applied_force_pn": null, "buffer": null, "environment": "in_silico", "ions": [], "ligands": [], "notes": "Computed prediction; no experimental conditions.", "ph": null, "salt_mM": null, "temperature_c": null }, "construct": { "description": "AlphaFold Monomer v2.0 pipeline, residues 1-662", "labels": [] }, "data_format": "mmCIF, PAE JSON", "data_level": "processed", "data_link": "https://alphafold.ebi.ac.uk/entry/O00571", "evidence_id": "EV-AFDB-AF-O00571-F1", "mappings": [], "molecule_id": "O00571", "observable": { "type": "plddt", "uncertainty": null, "unit": "pLDDT", "value": 72.19 }, "provenance": { "deposit_id": "AF-O00571-F1", "doi": null, "licence": "CC BY 4.0", "retrieved": "2026-10-19", "source": "AlphaFold DB", "url": "https://alphafold.ebi.ac.uk/entry/O00571" }, "reader": null, "source_kind": "computed", "technique": "af_prediction", "title": "AlphaFold DB prediction AF-O00571-F1" } ], "models": [], "molecule": { "components": [], "domains": [ { "end": 403, "name": "Helicase ATP-binding", "start": 211 }, { "end": 575, "name": "Helicase C-terminal", "start": 414 } ], "gene": "DDX3X", "identifiers": { "genbank": null, "isoform": null, "nakb": null, "pdb": [], "rfam": null, "rnacentral": null, "uniprot": "O00571" }, "ligands": [ "ATP" ], "modifications": [ { "kind": "ptm", "name": "N-acetylserine", "position": 2, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 55, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 82, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 86, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 90, "source": "UniProtKB" }, { "kind": "ptm", "name": "Omega-N-methylarginine", "position": 101, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by IKKE", "position": 102, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphotyrosine", "position": 104, "source": "UniProtKB" }, { "kind": "ptm", "name": "Omega-N-methylarginine", "position": 110, "source": "UniProtKB" }, { "kind": "ptm", "name": "N6-acetyllysine", "position": 118, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 131, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by TBK1; in vitro", "position": 181, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by TBK1", "position": 183, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by TBK1; in vitro", "position": 240, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by TBK1; in vitro", "position": 269, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CSNK1E and TBK1; in vitro", "position": 429, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine; by TBK1; in vitro", "position": 438, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by TBK1; in vitro", "position": 442, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by TBK1; in vitro", "position": 456, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine; by CSNK1E; in vitro", "position": 469, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CSNK1E; in vitro", "position": 470, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by TBK1; in vitro", "position": 520, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphothreonine; by TBK1; in vitro", "position": 542, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine; by CSNK1E and TBK1; in vitro", "position": 543, "source": "UniProtKB" }, { "kind": "ptm", "name": "Omega-N-methylarginine", "position": 592, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 594, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 605, "source": "UniProtKB" }, { "kind": "ptm", "name": "Phosphoserine", "position": 612, "source": "UniProtKB" }, { "kind": "ptm", "name": "Omega-N-methylarginine", "position": 617, "source": "UniProtKB" }, { "kind": "ptm", "name": "Omega-N-methylarginine", "position": 632, "source": "UniProtKB" } ], "molecule_id": "O00571", "molecule_type": "protein", "name": "ATP-dependent RNA helicase DDX3X", "organism": { "name": "Homo sapiens", "taxon_id": 9606 }, "provenance": { "deposit_id": "O00571", "doi": null, "licence": "CC BY 4.0 (UniProt)", "retrieved": "2026-10-19", "source": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O00571/entry" }, "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "sequence_length": 662 }, "molecule_id": "O00571", "states": [], "transitions": [] }